OTUD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.12744643
2nuclear pore organization (GO:0006999)6.62182705
3pore complex assembly (GO:0046931)5.31779089
4mitotic sister chromatid cohesion (GO:0007064)5.14091484
5pre-miRNA processing (GO:0031054)4.55140601
6histone H3-K36 demethylation (GO:0070544)4.36109690
7interkinetic nuclear migration (GO:0022027)4.20637161
8mitotic nuclear envelope disassembly (GO:0007077)4.18508100
9DNA unwinding involved in DNA replication (GO:0006268)4.16509070
10mitotic chromosome condensation (GO:0007076)4.10837982
11regulation of RNA export from nucleus (GO:0046831)4.10837932
12regulation of histone H3-K9 methylation (GO:0051570)4.07037228
13regulation of centriole replication (GO:0046599)4.01532946
14protein localization to kinetochore (GO:0034501)3.98484112
15membrane disassembly (GO:0030397)3.97005935
16nuclear envelope disassembly (GO:0051081)3.97005935
17negative regulation of histone methylation (GO:0031061)3.95100407
18heterochromatin organization (GO:0070828)3.80717711
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.78440277
20regulation of sister chromatid cohesion (GO:0007063)3.77350291
21chromatin assembly (GO:0031497)3.75866444
22monoubiquitinated protein deubiquitination (GO:0035520)3.73708802
23DNA duplex unwinding (GO:0032508)3.72827134
24DNA geometric change (GO:0032392)3.71322283
25folic acid-containing compound biosynthetic process (GO:0009396)3.70395527
26regulation of histone H3-K27 methylation (GO:0061085)3.65724337
27IMP biosynthetic process (GO:0006188)3.60973763
28kinetochore organization (GO:0051383)3.53857441
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.52421598
30positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.52421598
31positive regulation of mitotic sister chromatid separation (GO:1901970)3.52421598
32DNA replication-dependent nucleosome assembly (GO:0006335)3.50020817
33DNA replication-dependent nucleosome organization (GO:0034723)3.50020817
34protein localization to chromosome, centromeric region (GO:0071459)3.44725514
35histone H2A monoubiquitination (GO:0035518)3.44227230
36histone lysine demethylation (GO:0070076)3.43278911
37regulation of DNA endoreduplication (GO:0032875)3.38998857
38dosage compensation (GO:0007549)3.38552749
39regulation of posttranscriptional gene silencing (GO:0060147)3.35793575
40regulation of gene silencing by miRNA (GO:0060964)3.35793575
41regulation of gene silencing by RNA (GO:0060966)3.35793575
42regulation of NFAT protein import into nucleus (GO:0051532)3.30045338
43meiotic chromosome segregation (GO:0045132)3.27554778
44DNA replication initiation (GO:0006270)3.26403020
45negative regulation of neurotransmitter secretion (GO:0046929)3.25616171
46IMP metabolic process (GO:0046040)3.24546535
47histone demethylation (GO:0016577)3.24252199
48regulation of centrosome cycle (GO:0046605)3.20859092
49positive regulation of chromosome segregation (GO:0051984)3.20687951
50chromatin assembly or disassembly (GO:0006333)3.19374140
51sister chromatid cohesion (GO:0007062)3.17761704
52translesion synthesis (GO:0019985)3.17195820
53mRNA transcription (GO:0009299)3.16893419
54RNA stabilization (GO:0043489)3.15138016
55mRNA stabilization (GO:0048255)3.15138016
56gene silencing by RNA (GO:0031047)3.14539419
57regulation of nucleobase-containing compound transport (GO:0032239)3.13899684
58sister chromatid segregation (GO:0000819)3.12972861
59mitotic metaphase plate congression (GO:0007080)3.11318051
60hypotonic response (GO:0006971)3.09579056
61negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.08686730
62DNA conformation change (GO:0071103)3.08355536
63regulation of centrosome duplication (GO:0010824)3.08222098
64histone H3-K9 methylation (GO:0051567)3.07417712
65cytoplasmic mRNA processing body assembly (GO:0033962)3.06573999
66metaphase plate congression (GO:0051310)3.02985882
67nuclear envelope organization (GO:0006998)3.01682732
68negative regulation of DNA repair (GO:0045738)2.98840056
69nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.98824117
70regulation of translational termination (GO:0006449)2.98423793
71regulation of translational fidelity (GO:0006450)2.98012784
72chromatin remodeling at centromere (GO:0031055)2.96797398
73histone H3-K9 demethylation (GO:0033169)2.96210934
74definitive hemopoiesis (GO:0060216)2.96074644
75regulation of spindle organization (GO:0090224)2.95614547
76protein localization to chromosome (GO:0034502)2.93243127
77DNA replication-independent nucleosome assembly (GO:0006336)2.92930298
78DNA replication-independent nucleosome organization (GO:0034724)2.92930298
79mRNA transport (GO:0051028)2.92847550
80regulation of vitamin D biosynthetic process (GO:0060556)2.91698837
81peptidyl-lysine dimethylation (GO:0018027)2.91693411
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.90406313
83histone mRNA catabolic process (GO:0071044)2.90211475
84regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.89983127
85regulation of helicase activity (GO:0051095)2.89100378
86skeletal muscle contraction (GO:0003009)2.86541242
87chromosome condensation (GO:0030261)2.85947077
88ribosome assembly (GO:0042255)2.85712941
89NLS-bearing protein import into nucleus (GO:0006607)2.85712216
90negative regulation of histone modification (GO:0031057)2.84678001
91histone H3-K4 trimethylation (GO:0080182)2.82230299
92spliceosomal tri-snRNP complex assembly (GO:0000244)2.81450950
93attachment of spindle microtubules to kinetochore (GO:0008608)2.80416514
94regulation of mitotic spindle organization (GO:0060236)2.80174227
95protein K6-linked ubiquitination (GO:0085020)2.79978879
96mitotic sister chromatid segregation (GO:0000070)2.78049357
97CENP-A containing nucleosome assembly (GO:0034080)2.77909277
98response to UV-C (GO:0010225)2.77643762
99sarcoplasmic reticulum calcium ion transport (GO:0070296)2.77538264
100regulation of protein polyubiquitination (GO:1902914)2.76999656
101phospholipid scrambling (GO:0017121)2.76285239
102gene silencing (GO:0016458)2.75846745
103histone exchange (GO:0043486)2.75489375
104DNA packaging (GO:0006323)2.75085221
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73570949
106histone H4-K12 acetylation (GO:0043983)2.72659557
107negative regulation of chromatin modification (GO:1903309)2.71731014
108histone H3-K9 modification (GO:0061647)2.71200624
109regulation of chromosome segregation (GO:0051983)2.70898198
110regulation of gene silencing (GO:0060968)2.70581779
111RNA transport (GO:0050658)2.68424037
112establishment of RNA localization (GO:0051236)2.68424037
113nucleic acid transport (GO:0050657)2.68424037
114regulation of transforming growth factor beta2 production (GO:0032909)2.68059102
115positive regulation of DNA-templated transcription, initiation (GO:2000144)2.67585488
116protein demethylation (GO:0006482)2.67305334
117protein dealkylation (GO:0008214)2.67305334
118regulation of double-strand break repair (GO:2000779)2.66807157
119kinetochore assembly (GO:0051382)2.66798555
120mitotic recombination (GO:0006312)2.66624365
121regulation of DNA damage checkpoint (GO:2000001)2.66596773
122DNA strand elongation involved in DNA replication (GO:0006271)2.65506899
123mRNA transcription from RNA polymerase II promoter (GO:0042789)2.64084524
124muscle filament sliding (GO:0030049)2.62424464
125actin-myosin filament sliding (GO:0033275)2.62424464
126peptidyl-threonine phosphorylation (GO:0018107)2.60241245
127N-terminal protein amino acid acetylation (GO:0006474)2.59972697
128mannose metabolic process (GO:0006013)2.59611671
129negative regulation of potassium ion transmembrane transport (GO:1901380)2.55144932
130histone H3-K4 methylation (GO:0051568)2.54800147
131early endosome to late endosome transport (GO:0045022)2.54727846
132positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.54609170
133regulation of histone methylation (GO:0031060)2.53715631
134nucleus organization (GO:0006997)2.53543874
135protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.52792366
136regulation of interleukin-12 biosynthetic process (GO:0045075)2.52190056
137phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.52149851
138embryonic process involved in female pregnancy (GO:0060136)2.49097936
139positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.48902475
140peptidyl-threonine modification (GO:0018210)2.48777215
141actin-mediated cell contraction (GO:0070252)2.46921515
142pathway-restricted SMAD protein phosphorylation (GO:0060389)2.44968718
143histone lysine methylation (GO:0034968)2.44661550
144positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42381738
145positive regulation of histone H3-K4 methylation (GO:0051571)2.42215584
146skeletal muscle adaptation (GO:0043501)2.41940158
147striated muscle atrophy (GO:0014891)2.41585852
148peptidyl-lysine trimethylation (GO:0018023)2.40865182
149regulation of necroptotic process (GO:0060544)2.39892757
150positive regulation of protein import into nucleus, translocation (GO:0033160)2.35561402
151COPII vesicle coating (GO:0048208)2.35280805
152lipid translocation (GO:0034204)2.34561778
153phospholipid translocation (GO:0045332)2.34561778
154negative regulation of erythrocyte differentiation (GO:0045647)2.29169663
155actin filament-based movement (GO:0030048)2.27791547
156intestinal epithelial cell development (GO:0060576)2.27419180
157germinal center formation (GO:0002467)2.26790697
158positive regulation of histone methylation (GO:0031062)2.26623629
159positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.26536944
160positive regulation of granulocyte differentiation (GO:0030854)2.26489501
161bundle of His cell to Purkinje myocyte communication (GO:0086069)2.25986766
162negative regulation of necroptotic process (GO:0060546)2.25733350
163nucleus localization (GO:0051647)2.24825244
164coronary vasculature morphogenesis (GO:0060977)2.24704791
165glucocorticoid receptor signaling pathway (GO:0042921)2.24427170
166positive regulation of myotube differentiation (GO:0010831)2.24363874
167necroptotic process (GO:0070266)2.23860711
168cellular response to ethanol (GO:0071361)2.22800034
169regulation of chromatin silencing (GO:0031935)2.20847617
170myofibril assembly (GO:0030239)2.20266699
171cellular response to osmotic stress (GO:0071470)2.20160199
172establishment of protein localization to Golgi (GO:0072600)2.18762724
173histone H4-K16 acetylation (GO:0043984)2.17198449
174retrograde transport, vesicle recycling within Golgi (GO:0000301)2.13485599
175regulation of histone H3-K4 methylation (GO:0051569)2.12458267
176protein targeting to Golgi (GO:0000042)2.12419504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.37261714
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.21048317
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.92679290
4* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.36278456
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.21239201
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03447169
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.95955103
8* MYC_18555785_ChIP-Seq_MESCs_Mouse2.94164843
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.81798136
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.71891161
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55923145
12MYC_22102868_ChIP-Seq_BL_Human2.47950539
13AR_21909140_ChIP-Seq_LNCAP_Human2.47581951
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24791631
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.18106004
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16185471
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13526912
18E2F7_22180533_ChIP-Seq_HELA_Human11.0078634
19MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96655807
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89351229
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89247003
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88662975
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85478226
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.84736974
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82515439
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.79293914
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79046280
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77877584
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.74360895
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73633343
31RUNX_20019798_ChIP-Seq_JUKART_Human1.67766071
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67323688
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.66071428
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65767175
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63386862
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.63089044
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62186965
38* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59603239
39CIITA_25753668_ChIP-Seq_RAJI_Human1.50826068
40CTNNB1_20460455_ChIP-Seq_HCT116_Human1.46709484
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46368718
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46057200
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43713811
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43694288
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40818830
46VDR_24787735_ChIP-Seq_THP-1_Human1.40415551
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39467234
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.39383910
49SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38085335
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36149504
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34336298
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33872509
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31836438
54ELK1_19687146_ChIP-ChIP_HELA_Human1.31771795
55DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31157378
56* EP300_21415370_ChIP-Seq_HL-1_Mouse1.30320115
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30000871
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29878544
59KDM5A_27292631_Chip-Seq_BREAST_Human1.29834139
60* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28207988
61SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27611525
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26088663
63TCF7_22412390_ChIP-Seq_EML_Mouse1.25798823
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24200120
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23793507
66NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23621777
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22900695
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21858293
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21858293
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21858293
71PU_27001747_Chip-Seq_BMDM_Mouse1.20814273
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19931691
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19393668
74VDR_23849224_ChIP-Seq_CD4+_Human1.18893824
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17355905
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.16986537
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16524794
78XRN2_22483619_ChIP-Seq_HELA_Human1.15194160
79TP63_23658742_ChIP-Seq_EP156T_Human1.14594613
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14524601
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.14499209
82* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13902464
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13733966
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12909207
85GATA1_22025678_ChIP-Seq_K562_Human1.12677339
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12061310
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12051560
88CLOCK_20551151_ChIP-Seq_293T_Human1.11745926
89* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10304334
90MYB_26560356_Chip-Seq_TH1_Human1.10049371
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07980780
92TP53_16413492_ChIP-PET_HCT116_Human1.07928419
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07585035
94TFEB_21752829_ChIP-Seq_HELA_Human1.06516434
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06350037
96TBX20_22328084_ChIP-Seq_HEART_Mouse1.05085230
97TBX20_22080862_ChIP-Seq_HEART_Mouse1.05085230
98TP63_17297297_ChIP-ChIP_HaCaT_Human1.04854812
99* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04290768
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03820177
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03694840
102CHD1_26751641_Chip-Seq_LNCaP_Human1.03373846
103PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03063603
104FOXP3_21729870_ChIP-Seq_TREG_Human1.02880843
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02849552
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02585918
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02441376
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02438108
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02401656
110WT1_19549856_ChIP-ChIP_CCG9911_Human1.02372125
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01708239
112GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01579137
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01365912
114CJUN_26792858_Chip-Seq_BT549_Human1.00782465
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00492378
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99178404
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97742894
118FOXA2_19822575_ChIP-Seq_HepG2_Human0.97610927
119MYB_26560356_Chip-Seq_TH2_Human0.97039172
120TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95353831
121FLI1_27457419_Chip-Seq_LIVER_Mouse0.95293163
122TTF2_22483619_ChIP-Seq_HELA_Human0.95178653
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94858698
124CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94810872
125SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94773569
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94237983
127SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92670742
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91979783
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91805273
130FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91788976
131PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91687833
132BP1_19119308_ChIP-ChIP_Hs578T_Human0.91534935
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91016662
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90971822
135HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90842121
136* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90708249
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90463423
138MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89828772
139NANOG_21062744_ChIP-ChIP_HESCs_Human0.89817355
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89513431
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89410414
142KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87528735
143MAF_26560356_Chip-Seq_TH1_Human0.87485911
144UTX_26944678_Chip-Seq_JUKART_Human0.87471084
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87258566
146SCL_19346495_ChIP-Seq_HPC-7_Human0.87225024
147VDR_21846776_ChIP-Seq_THP-1_Human0.86795223
148FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86352168
149HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84906113
150FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.84759469
151* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84616980
152NCOR1_26117541_ChIP-Seq_K562_Human0.84474118
153SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81790520
154SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81790520
155ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80379339
156EST1_17652178_ChIP-ChIP_JURKAT_Human0.78909742
157BRD4_25478319_ChIP-Seq_HGPS_Human0.78306712
158BRD4_27068464_Chip-Seq_AML-cells_Mouse0.78261135
159TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77917754
160GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76073446
161NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.75255836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.83812891
2MP0008057_abnormal_DNA_replication3.62410373
3MP0010352_gastrointestinal_tract_polyps3.32757656
4MP0003111_abnormal_nucleus_morphology3.24630263
5MP0003693_abnormal_embryo_hatching3.10165583
6MP0003077_abnormal_cell_cycle3.06388824
7MP0004957_abnormal_blastocyst_morpholog2.94464960
8MP0008877_abnormal_DNA_methylation2.71250535
9MP0010307_abnormal_tumor_latency2.55323587
10MP0005076_abnormal_cell_differentiation2.50114900
11MP0000569_abnormal_digit_pigmentation2.44949197
12MP0008058_abnormal_DNA_repair2.36511651
13MP0008007_abnormal_cellular_replicative2.35648466
14MP0003646_muscle_fatigue2.33235000
15MP0001730_embryonic_growth_arrest2.28831313
16MP0002396_abnormal_hematopoietic_system2.21371938
17MP0003123_paternal_imprinting2.20834925
18MP0005451_abnormal_body_composition2.19750803
19MP0003656_abnormal_erythrocyte_physiolo2.13844709
20MP0000350_abnormal_cell_proliferation2.11228192
21MP0004197_abnormal_fetal_growth/weight/1.98597436
22MP0003705_abnormal_hypodermis_morpholog1.95902260
23MP0004808_abnormal_hematopoietic_stem1.95014829
24MP0001672_abnormal_embryogenesis/_devel1.94515602
25MP0005380_embryogenesis_phenotype1.94515602
26MP0003453_abnormal_keratinocyte_physiol1.87967943
27MP0003121_genomic_imprinting1.86925756
28MP0003984_embryonic_growth_retardation1.85598980
29MP0002086_abnormal_extraembryonic_tissu1.85047270
30MP0003828_pulmonary_edema1.84977083
31MP0004036_abnormal_muscle_relaxation1.84507715
32MP0002332_abnormal_exercise_endurance1.84067381
33MP0002088_abnormal_embryonic_growth/wei1.82870751
34MP0002084_abnormal_developmental_patter1.82373922
35MP0004084_abnormal_cardiac_muscle1.73745853
36MP0001697_abnormal_embryo_size1.70540938
37MP0010234_abnormal_vibrissa_follicle1.64795071
38MP0003950_abnormal_plasma_membrane1.64477587
39MP0004233_abnormal_muscle_weight1.61835624
40MP0003890_abnormal_embryonic-extraembry1.60813257
41MP0003303_peritoneal_inflammation1.57089510
42MP0002085_abnormal_embryonic_tissue1.55882854
43MP0004510_myositis1.55845035
44MP0002877_abnormal_melanocyte_morpholog1.54320334
45MP0003567_abnormal_fetal_cardiomyocyte1.53340929
46MP0008961_abnormal_basal_metabolism1.46434328
47MP0000733_abnormal_muscle_development1.45041624
48MP0004087_abnormal_muscle_fiber1.43905779
49MP0002080_prenatal_lethality1.43708642
50MP0003566_abnormal_cell_adhesion1.36559524
51MP0003787_abnormal_imprinting1.36497992
52MP0001873_stomach_inflammation1.32383920
53MP0000537_abnormal_urethra_morphology1.32222057
54MP0002106_abnormal_muscle_physiology1.31106539
55MP0004264_abnormal_extraembryonic_tissu1.31092452
56MP0008932_abnormal_embryonic_tissue1.30322300
57MP0000759_abnormal_skeletal_muscle1.29975073
58MP0001915_intracranial_hemorrhage1.29747665
59MP0005666_abnormal_adipose_tissue1.28331385
60MP0001293_anophthalmia1.27972240
61MP0002138_abnormal_hepatobiliary_system1.27348904
62MP0000749_muscle_degeneration1.25411709
63MP0004947_skin_inflammation1.23727888
64MP0003221_abnormal_cardiomyocyte_apopto1.22646775
65MP0003300_gastrointestinal_ulcer1.22605971
66MP0009053_abnormal_anal_canal1.21545224
67MP0001835_abnormal_antigen_presentation1.21471799
68MP0005409_darkened_coat_color1.20341419
69MP0000490_abnormal_crypts_of1.19975620
70MP0009672_abnormal_birth_weight1.19822604
71MP0002210_abnormal_sex_determination1.19272543
72MP0003786_premature_aging1.18921350
73MP0002405_respiratory_system_inflammati1.16859393
74MP0002019_abnormal_tumor_incidence1.16235707
75MP0003763_abnormal_thymus_physiology1.14200201
76MP0000313_abnormal_cell_death1.12803002
77MP0009703_decreased_birth_body1.12140687
78MP0000751_myopathy1.09847949
79MP0002796_impaired_skin_barrier1.09289230
80MP0002166_altered_tumor_susceptibility1.07539014
81MP0002925_abnormal_cardiovascular_devel1.06512905
82MP0001790_abnormal_immune_system1.05921616
83MP0005387_immune_system_phenotype1.05921616
84MP0003937_abnormal_limbs/digits/tail_de1.05908012
85MP0002269_muscular_atrophy1.04564385
86MP0000703_abnormal_thymus_morphology1.03713652
87MP0002998_abnormal_bone_remodeling1.02902544
88MP0001800_abnormal_humoral_immune1.02388947
89MP0005369_muscle_phenotype1.02305841
90MP0000383_abnormal_hair_follicle1.02071032
91MP0004782_abnormal_surfactant_physiolog1.01204669
92MP0000428_abnormal_craniofacial_morphol1.00349257
93MP0004484_altered_response_of1.00072389
94MP0001145_abnormal_male_reproductive0.99368202
95MP0005375_adipose_tissue_phenotype0.99205915
96MP0002006_tumorigenesis0.98484695
97MP0001929_abnormal_gametogenesis0.98104336
98MP0002398_abnormal_bone_marrow0.97072963
99MP0003436_decreased_susceptibility_to0.95951008
100MP0004145_abnormal_muscle_electrophysio0.95320653
101MP0010630_abnormal_cardiac_muscle0.94991273
102MP0002092_abnormal_eye_morphology0.94680553
103MP0005397_hematopoietic_system_phenotyp0.94074181
104MP0001545_abnormal_hematopoietic_system0.94074181
105MP0009115_abnormal_fat_cell0.93921487
106MP0000432_abnormal_head_morphology0.91496528
107MP0009278_abnormal_bone_marrow0.91445062
108MP0001216_abnormal_epidermal_layer0.89210778
109MP0003045_fibrosis0.88884895
110MP0006054_spinal_hemorrhage0.88754367
111MP0003119_abnormal_digestive_system0.88547947
112MP0000747_muscle_weakness0.88267121
113MP0002697_abnormal_eye_size0.86489485
114MP0005623_abnormal_meninges_morphology0.85670891
115MP0000653_abnormal_sex_gland0.85452907
116MP0003448_altered_tumor_morphology0.85249474
117MP0003943_abnormal_hepatobiliary_system0.85181337
118MP0003935_abnormal_craniofacial_develop0.84781637
119MP0000516_abnormal_urinary_system0.83876021
120MP0005367_renal/urinary_system_phenotyp0.83876021
121MP0005023_abnormal_wound_healing0.83267663
122MP0002060_abnormal_skin_morphology0.83130753
123MP0003115_abnormal_respiratory_system0.81359392
124MP0000266_abnormal_heart_morphology0.80976281
125MP0005000_abnormal_immune_tolerance0.80010989
126MP0010368_abnormal_lymphatic_system0.79670218
127MP0005310_abnormal_salivary_gland0.79270577
128MP0005621_abnormal_cell_physiology0.79049248
129MP0005266_abnormal_metabolism0.78805813
130MP0010678_abnormal_skin_adnexa0.77434466
131MP0003941_abnormal_skin_development0.77384484
132MP0002452_abnormal_antigen_presenting0.76458035
133MP0010155_abnormal_intestine_physiology0.75963254
134MP0002722_abnormal_immune_system0.75675276
135MP0003091_abnormal_cell_migration0.75428248
136MP0004185_abnormal_adipocyte_glucose0.74300861
137MP0002009_preneoplasia0.73715708
138MP0001286_abnormal_eye_development0.72205854
139MP0001849_ear_inflammation0.72039362
140MP0000689_abnormal_spleen_morphology0.69741017
141MP0005384_cellular_phenotype0.68724808
142MP0001784_abnormal_fluid_regulation0.68655884
143MP0008770_decreased_survivor_rate0.68122153
144MP0008995_early_reproductive_senescence0.66307382
145MP0001119_abnormal_female_reproductive0.65669689
146MP0002111_abnormal_tail_morphology0.64026142
147MP0000627_abnormal_mammary_gland0.63221713
148MP0005187_abnormal_penis_morphology0.62580290
149MP0001853_heart_inflammation0.60598756
150MP0003936_abnormal_reproductive_system0.60079728

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)4.76778972
2Muscle fiber inclusion bodies (HP:0100299)4.68011493
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.56436290
4Subaortic stenosis (HP:0001682)3.95069695
5Abnormality of the left ventricular outflow tract (HP:0011103)3.95069695
6Chromsome breakage (HP:0040012)3.49965940
7Exercise-induced myalgia (HP:0003738)3.49955572
8Volvulus (HP:0002580)3.43236432
9Selective tooth agenesis (HP:0001592)3.35950212
10Type 1 muscle fiber predominance (HP:0003803)3.33272823
11Distal arthrogryposis (HP:0005684)3.19121983
12Dysmetric saccades (HP:0000641)3.13054245
13Ependymoma (HP:0002888)3.13015506
14Abnormality of the fingertips (HP:0001211)3.06797140
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.04960185
16Hyperkalemia (HP:0002153)2.90945323
17Ectopic kidney (HP:0000086)2.83172714
18Abnormality of chromosome stability (HP:0003220)2.81079680
19Medulloblastoma (HP:0002885)2.80896260
20Lip pit (HP:0100267)2.72097985
21Subacute progressive viral hepatitis (HP:0006572)2.69128788
22Deviation of the thumb (HP:0009603)2.67578286
23Ulnar deviation of the wrist (HP:0003049)2.64867612
24Colon cancer (HP:0003003)2.64251165
25Acute myeloid leukemia (HP:0004808)2.63194003
26Astrocytoma (HP:0009592)2.62778484
27Abnormality of the astrocytes (HP:0100707)2.62778484
28Neoplasm of the oral cavity (HP:0100649)2.59539997
29Rhabdomyosarcoma (HP:0002859)2.55992755
30Right ventricular cardiomyopathy (HP:0011663)2.54540264
31Proximal placement of thumb (HP:0009623)2.51617999
32Long eyelashes (HP:0000527)2.49332911
33Biliary tract neoplasm (HP:0100574)2.42717056
34Short 4th metacarpal (HP:0010044)2.37858680
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37858680
36Heterotopia (HP:0002282)2.37146762
37Prominent nose (HP:0000448)2.35508715
38Round ear (HP:0100830)2.35438344
39Fatigue (HP:0012378)2.35134395
40Abnormality of the labia minora (HP:0012880)2.34034038
41Supernumerary spleens (HP:0009799)2.33570057
42Birth length less than 3rd percentile (HP:0003561)2.33565480
43Spondylolisthesis (HP:0003302)2.32549177
44Sandal gap (HP:0001852)2.32053622
45Muscle fiber splitting (HP:0003555)2.28943979
46Myelodysplasia (HP:0002863)2.28583116
47Increased nuchal translucency (HP:0010880)2.28556741
48Basal cell carcinoma (HP:0002671)2.28429494
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.28135799
50Asymmetric septal hypertrophy (HP:0001670)2.27094574
51Flat acetabular roof (HP:0003180)2.25640067
52Dislocated radial head (HP:0003083)2.24350488
53Ankyloglossia (HP:0010296)2.20224088
54Glioma (HP:0009733)2.19622682
55Exercise-induced muscle cramps (HP:0003710)2.18767801
56Muscle hypertrophy of the lower extremities (HP:0008968)2.18363142
57Malignant gastrointestinal tract tumors (HP:0006749)2.15785977
58Gastrointestinal carcinoma (HP:0002672)2.15785977
59Missing ribs (HP:0000921)2.11733078
60Rectal prolapse (HP:0002035)2.07834860
61Amaurosis fugax (HP:0100576)2.06951623
62Truncal obesity (HP:0001956)2.06911388
63Absent frontal sinuses (HP:0002688)2.06863362
64Abnormality of oral frenula (HP:0000190)2.06691972
65Increased density of long bones (HP:0006392)2.06395742
66Agnosia (HP:0010524)2.05300385
67Skull defect (HP:0001362)2.04286651
68Neoplasm of striated muscle (HP:0009728)2.04098955
69Cystic hygroma (HP:0000476)2.03746428
70Nephroblastoma (Wilms tumor) (HP:0002667)2.01642741
71Malignant hyperthermia (HP:0002047)2.00755156
72Facial hemangioma (HP:0000329)1.99950790
73Aortic aneurysm (HP:0004942)1.99905436
74Papillary thyroid carcinoma (HP:0002895)1.99591904
75Difficulty running (HP:0009046)1.99439794
76Deep philtrum (HP:0002002)1.99290616
77Embryonal renal neoplasm (HP:0011794)1.98932395
78Bundle branch block (HP:0011710)1.98350243
7911 pairs of ribs (HP:0000878)1.98010172
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.97956569
81Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96745648
82Genetic anticipation (HP:0003743)1.96520825
83Neonatal hypoglycemia (HP:0001998)1.95842952
84Abnormality of the radial head (HP:0003995)1.95161451
85Urethral obstruction (HP:0000796)1.94607025
86Increased connective tissue (HP:0009025)1.94185416
87EMG: myopathic abnormalities (HP:0003458)1.91639006
88Osteolytic defects of the phalanges of the hand (HP:0009771)1.91158775
89Osteolytic defects of the hand bones (HP:0009699)1.91158775
90Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.91082248
91Meckel diverticulum (HP:0002245)1.90631083
92Neck muscle weakness (HP:0000467)1.90451333
93Cafe-au-lait spot (HP:0000957)1.90204716
94Rimmed vacuoles (HP:0003805)1.88993979
95High pitched voice (HP:0001620)1.88398775
96Low anterior hairline (HP:0000294)1.87429253
97Distal lower limb amyotrophy (HP:0008944)1.86147210
98Cubitus valgus (HP:0002967)1.85630878
99Autoimmune hemolytic anemia (HP:0001890)1.85384187
100Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.82840245
101Pelvic girdle muscle weakness (HP:0003749)1.82460240
102Overgrowth (HP:0001548)1.82240380
103Abnormality of DNA repair (HP:0003254)1.82101075
104Abnormality of the carotid arteries (HP:0005344)1.80731033
105Abnormality of the preputium (HP:0100587)1.80716501
106Cutaneous melanoma (HP:0012056)1.80566735
107Abnormality of the ileum (HP:0001549)1.78493471
108Obsessive-compulsive behavior (HP:0000722)1.77476560
109Spinal cord lesions (HP:0100561)1.76520845
110Syringomyelia (HP:0003396)1.76520845
111Abnormality of chromosome segregation (HP:0002916)1.75586629
112Sloping forehead (HP:0000340)1.74991937
113Abnormality of the calcaneus (HP:0008364)1.74123040
114Trigonocephaly (HP:0000243)1.73856110
115Abnormality of skeletal muscle fiber size (HP:0012084)1.73622156
116Abnormal biliary tract morphology (HP:0012440)1.73414923
117Supernumerary ribs (HP:0005815)1.72197299
118Hyporeflexia of lower limbs (HP:0002600)1.70538084
119Small intestinal stenosis (HP:0012848)1.70320872
120Duodenal stenosis (HP:0100867)1.70320872
121Cutis marmorata (HP:0000965)1.70124904
122Impulsivity (HP:0100710)1.70024708
123Mitral valve prolapse (HP:0001634)1.70000806
124Calcaneovalgus deformity (HP:0001848)1.69817891
125T lymphocytopenia (HP:0005403)1.69276654
126Short humerus (HP:0005792)1.68683437
127Abnormal number of incisors (HP:0011064)1.68472545
128Squamous cell carcinoma (HP:0002860)1.68439404
129Abnormality of the nasal septum (HP:0000419)1.68015719
130Neoplasm of the small intestine (HP:0100833)1.67925258
131Acute lymphatic leukemia (HP:0006721)1.67602847
132Broad palm (HP:0001169)1.66790748
133Narrow palate (HP:0000189)1.65519134
134Abnormality of the salivary glands (HP:0010286)1.65333888
135Hematochezia (HP:0002573)1.65167468
136Supernumerary bones of the axial skeleton (HP:0009144)1.64834643
137Hyperacusis (HP:0010780)1.64753384
138Broad thumb (HP:0011304)1.64639101
139Transitional cell carcinoma of the bladder (HP:0006740)1.64210141
140Ventricular tachycardia (HP:0004756)1.63558049
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.63437238
142Persistence of primary teeth (HP:0006335)1.62705940
143Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.62545623
144Short 1st metacarpal (HP:0010034)1.62545623
145Short middle phalanx of the 5th finger (HP:0004220)1.61905115
146Arterial tortuosity (HP:0005116)1.61526899
147Hypoplastic labia majora (HP:0000059)1.61481642
148Uterine neoplasm (HP:0010784)1.60816422
149Patellar aplasia (HP:0006443)1.60776384
150Thyroid carcinoma (HP:0002890)1.60132742
151Absent radius (HP:0003974)1.60106602
152Renovascular hypertension (HP:0100817)1.59818627
153Short chin (HP:0000331)1.58806669
154Macroorchidism (HP:0000053)1.58434534
155Abnormality of T cell number (HP:0011839)1.58209865
156Blepharitis (HP:0000498)1.58076869
157Popliteal pterygium (HP:0009756)1.57697433
158Recurrent viral infections (HP:0004429)1.56497397
159Myopathic facies (HP:0002058)1.56053233
160Male infertility (HP:0003251)1.54589784
161Limited elbow extension (HP:0001377)1.54116450
162Anal stenosis (HP:0002025)1.53709187
163Abnormality of the common coagulation pathway (HP:0010990)1.53581999
164Vertebral arch anomaly (HP:0008438)1.53152880
165Mildly elevated creatine phosphokinase (HP:0008180)1.53027647
166Spinal rigidity (HP:0003306)1.52090824
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.51294085
168Fused cervical vertebrae (HP:0002949)1.50924132
169Aplasia/Hypoplasia of the scapulae (HP:0006713)1.50195332
170Hypoplastic scapulae (HP:0000882)1.50195332
171Calf muscle hypertrophy (HP:0008981)1.49577233
172Abnormality of the lumbar spine (HP:0100712)1.49445160
173Menstrual irregularities (HP:0000858)1.49210717
174Vascular tortuosity (HP:0004948)1.48823423
175Bladder carcinoma (HP:0002862)1.47843450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.07528460
2CDC74.68237071
3OBSCN2.92935136
4LATS12.57238297
5NEK22.48963180
6BRD42.45600235
7PRPF4B2.37196385
8EEF2K2.28570229
9MKNK22.18642287
10WEE12.02583424
11PKN22.01163455
12NLK2.00279658
13MKNK11.98083174
14TTK1.81069067
15STK31.76546955
16SRPK11.76350582
17MAP3K101.76030311
18CDK61.67278361
19PASK1.67179532
20CDK41.66367058
21WNK11.65870603
22ATR1.64782445
23MST1R1.63382204
24RPS6KA41.62788414
25TTN1.59566127
26STK101.58356772
27MAP3K131.52619830
28CHEK11.52545792
29RPS6KB21.48841308
30EPHA21.48464679
31SCYL21.47859163
32ACVR1B1.43264168
33MET1.41275470
34PIK3CG1.40323041
35ALK1.36033708
36AURKB1.35605496
37TGFBR11.31774231
38ATM1.31732049
39PLK41.30909384
40CDK71.28995412
41MELK1.23295258
42CHEK21.22230917
43PLK11.21900127
44MAP3K81.20729440
45STK41.19865500
46MTOR1.18961905
47FGFR41.18141187
48TSSK61.16544011
49CDK91.14847558
50MAP3K91.13559623
51CAMK1D1.12313233
52IRAK31.11920765
53NEK11.08290114
54SGK31.08209256
55BRSK21.07939336
56PBK1.04430098
57PLK31.01924726
58JAK31.01110836
59PTK61.00388365
60ZAK1.00346812
61FGFR31.00202449
62CDK20.98234311
63AKT30.96383218
64SGK20.94033330
65FLT30.93478172
66PIM10.92132090
67TGFBR20.87139192
68JAK10.86480681
69ZAP700.86282124
70CSNK1D0.84186637
71PDGFRB0.81892810
72IKBKE0.81519113
73MAP3K70.81185071
74CDC42BPA0.81129551
75RIPK10.78873966
76PDGFRA0.78756320
77FGFR10.78438172
78STK38L0.77554108
79IRAK10.77508021
80SMG10.76997812
81TEC0.74793044
82MAP2K30.74687680
83NEK60.74121322
84CDK10.74110262
85TNIK0.71294581
86EIF2AK20.69326164
87CHUK0.66211024
88MAPK70.65728589
89KSR20.65466813
90STK380.64591215
91PAK40.64574423
92TRIB30.63545206
93PRKDC0.63417403
94CLK10.63223288
95MAPK110.63162637
96MAP4K10.62679877
97PAK20.62173525
98DYRK30.61872793
99ICK0.61745632
100DMPK0.61095801
101CAMK1G0.60770747
102PNCK0.59979171
103STK240.59892728
104FRK0.59116269
105MAPK140.58335202
106KSR10.57297383
107CSNK1E0.57012565
108YES10.57008594
109LRRK20.56794593
110NUAK10.53633492
111MOS0.53361407
112BMX0.53248243
113MST40.52900528
114NEK90.52495080
115KIT0.51833400
116TAF10.50692026
117RPS6KB10.49390543
118ERBB30.48863444
119TRPM70.48580632
120CSK0.48532020
121MARK20.47265538
122AKT10.46839563
123MAP3K10.46623027
124AKT20.46289908
125PRKAA20.46289351
126BCKDK0.45264039
127MAP3K140.45197056
128GSK3B0.44742709
129PDK40.44296411
130PDK30.44296411
131MAPK10.43765217
132MAP3K60.43592046
133CDK80.43486257
134CSNK2A20.43312326
135TYK20.40419094
136IKBKB0.40118392
137MAP3K20.37846005
138MAP3K30.37543689
139ITK0.37383695
140TYRO30.37322250
141EIF2AK10.37221206
142EIF2AK30.36749112
143MAPK120.36002710
144MAPK100.35244629
145MARK30.34913881
146LATS20.32970830
147TLK10.32146999
148EGFR0.32136536

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07522596
2DNA replication_Homo sapiens_hsa030303.01254785
3One carbon pool by folate_Homo sapiens_hsa006702.85530987
4Mismatch repair_Homo sapiens_hsa034302.78136569
5RNA transport_Homo sapiens_hsa030132.75513299
6Cell cycle_Homo sapiens_hsa041102.54664596
7Non-homologous end-joining_Homo sapiens_hsa034502.36627984
8mRNA surveillance pathway_Homo sapiens_hsa030152.26747533
9Spliceosome_Homo sapiens_hsa030402.15355310
10Fanconi anemia pathway_Homo sapiens_hsa034602.04764316
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04528306
12RNA degradation_Homo sapiens_hsa030181.94071687
13Homologous recombination_Homo sapiens_hsa034401.86207970
14Nucleotide excision repair_Homo sapiens_hsa034201.83347869
15Base excision repair_Homo sapiens_hsa034101.78410262
16Systemic lupus erythematosus_Homo sapiens_hsa053221.68423186
17Lysine degradation_Homo sapiens_hsa003101.67195091
18Small cell lung cancer_Homo sapiens_hsa052221.66843393
19MicroRNAs in cancer_Homo sapiens_hsa052061.57258290
20p53 signaling pathway_Homo sapiens_hsa041151.53988428
21Basal transcription factors_Homo sapiens_hsa030221.50376406
22Renal cell carcinoma_Homo sapiens_hsa052111.50117556
23Viral carcinogenesis_Homo sapiens_hsa052031.48862236
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42021826
25Circadian rhythm_Homo sapiens_hsa047101.41254181
26Antigen processing and presentation_Homo sapiens_hsa046121.37822864
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37680059
28Herpes simplex infection_Homo sapiens_hsa051681.36665446
29Adherens junction_Homo sapiens_hsa045201.34815278
30Hepatitis C_Homo sapiens_hsa051601.25440926
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25253900
32HTLV-I infection_Homo sapiens_hsa051661.25104712
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22835482
34Chronic myeloid leukemia_Homo sapiens_hsa052201.21707255
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17966892
36Thyroid cancer_Homo sapiens_hsa052161.16129326
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15502605
38mTOR signaling pathway_Homo sapiens_hsa041501.14757576
39Amoebiasis_Homo sapiens_hsa051461.14122332
40TGF-beta signaling pathway_Homo sapiens_hsa043501.12056684
41Selenocompound metabolism_Homo sapiens_hsa004501.10631119
42VEGF signaling pathway_Homo sapiens_hsa043701.09121292
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.07832853
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06737808
45ErbB signaling pathway_Homo sapiens_hsa040121.06615939
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00848480
47Insulin signaling pathway_Homo sapiens_hsa049100.98942857
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98857309
49Viral myocarditis_Homo sapiens_hsa054160.97120289
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96439802
51Notch signaling pathway_Homo sapiens_hsa043300.94785550
52Colorectal cancer_Homo sapiens_hsa052100.93693909
53Oocyte meiosis_Homo sapiens_hsa041140.91441754
54Proteoglycans in cancer_Homo sapiens_hsa052050.90296508
55Allograft rejection_Homo sapiens_hsa053300.89843571
56Epstein-Barr virus infection_Homo sapiens_hsa051690.89637883
57Hippo signaling pathway_Homo sapiens_hsa043900.87532414
58RNA polymerase_Homo sapiens_hsa030200.86415286
59Glioma_Homo sapiens_hsa052140.85502361
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.84015474
61Measles_Homo sapiens_hsa051620.83894723
62Hepatitis B_Homo sapiens_hsa051610.83872356
63Prostate cancer_Homo sapiens_hsa052150.82844576
64Pancreatic cancer_Homo sapiens_hsa052120.82689373
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.82574568
66Choline metabolism in cancer_Homo sapiens_hsa052310.81773158
67Non-small cell lung cancer_Homo sapiens_hsa052230.81638821
68Basal cell carcinoma_Homo sapiens_hsa052170.80841320
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80603882
70MAPK signaling pathway_Homo sapiens_hsa040100.80240950
71Toxoplasmosis_Homo sapiens_hsa051450.80007496
72Pyrimidine metabolism_Homo sapiens_hsa002400.79717409
73Malaria_Homo sapiens_hsa051440.78751767
74Acute myeloid leukemia_Homo sapiens_hsa052210.76095907
75Dilated cardiomyopathy_Homo sapiens_hsa054140.75869292
76Pathways in cancer_Homo sapiens_hsa052000.74967844
77Apoptosis_Homo sapiens_hsa042100.74515171
78Focal adhesion_Homo sapiens_hsa045100.73972191
79Influenza A_Homo sapiens_hsa051640.73294007
80Primary immunodeficiency_Homo sapiens_hsa053400.72688275
81Dorso-ventral axis formation_Homo sapiens_hsa043200.72666582
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.71827200
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69160323
84GnRH signaling pathway_Homo sapiens_hsa049120.67781468
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.67566476
86B cell receptor signaling pathway_Homo sapiens_hsa046620.66609844
87T cell receptor signaling pathway_Homo sapiens_hsa046600.66605648
88Type II diabetes mellitus_Homo sapiens_hsa049300.66155152
89FoxO signaling pathway_Homo sapiens_hsa040680.66111388
90Endometrial cancer_Homo sapiens_hsa052130.65777766
91Tuberculosis_Homo sapiens_hsa051520.64445520
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64159353
93Leishmaniasis_Homo sapiens_hsa051400.63507105
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61465935
95Chemokine signaling pathway_Homo sapiens_hsa040620.61220193
96African trypanosomiasis_Homo sapiens_hsa051430.61095386
97ECM-receptor interaction_Homo sapiens_hsa045120.60731641
98Alcoholism_Homo sapiens_hsa050340.60448828
99Legionellosis_Homo sapiens_hsa051340.60134334
100HIF-1 signaling pathway_Homo sapiens_hsa040660.59120014
101TNF signaling pathway_Homo sapiens_hsa046680.59083780
102Autoimmune thyroid disease_Homo sapiens_hsa053200.58577201
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57946845
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57765092
105Hematopoietic cell lineage_Homo sapiens_hsa046400.57134443
106AMPK signaling pathway_Homo sapiens_hsa041520.57017113
107Asthma_Homo sapiens_hsa053100.56379948
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.56325756
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.56200403
110Insulin resistance_Homo sapiens_hsa049310.54855582
111Wnt signaling pathway_Homo sapiens_hsa043100.53480999
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51882691
113Platelet activation_Homo sapiens_hsa046110.51453858
114Osteoclast differentiation_Homo sapiens_hsa043800.49639307
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49275092
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47961746
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47662129
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.47295671
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47159616
120Inositol phosphate metabolism_Homo sapiens_hsa005620.46835549
121Tight junction_Homo sapiens_hsa045300.45923229
122Bladder cancer_Homo sapiens_hsa052190.45790495
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45111637
124Prolactin signaling pathway_Homo sapiens_hsa049170.44727698
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42109982
126Melanoma_Homo sapiens_hsa052180.39842426
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39750706
128Glucagon signaling pathway_Homo sapiens_hsa049220.39219404
129Shigellosis_Homo sapiens_hsa051310.38004203
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37827197
131Hedgehog signaling pathway_Homo sapiens_hsa043400.37012222
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36415567

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