OTUD4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.28053001
2synapsis (GO:0007129)5.82284253
3piRNA metabolic process (GO:0034587)5.33332968
4epithelial cilium movement (GO:0003351)5.25860287
5axonemal dynein complex assembly (GO:0070286)5.24168265
6cilium or flagellum-dependent cell motility (GO:0001539)4.88429022
7chromosome organization involved in meiosis (GO:0070192)4.85580862
8viral transcription (GO:0019083)4.65911634
9positive regulation of gastrulation (GO:2000543)4.62025271
10translational termination (GO:0006415)4.59586528
11cilium movement (GO:0003341)4.44875613
12DNA synthesis involved in DNA repair (GO:0000731)4.30689828
13male meiosis I (GO:0007141)4.27185730
14regulation of chronic inflammatory response (GO:0002676)4.22475591
15synaptonemal complex assembly (GO:0007130)4.21665991
16regulation of podosome assembly (GO:0071801)4.19976672
17regulation of isotype switching to IgG isotypes (GO:0048302)4.08351697
18CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.06058613
19ribosomal small subunit assembly (GO:0000028)3.98055499
20neural tube formation (GO:0001841)3.90989862
21regulation of meiosis I (GO:0060631)3.71556372
22cotranslational protein targeting to membrane (GO:0006613)3.70312080
23maturation of SSU-rRNA (GO:0030490)3.70148278
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65392632
25base-excision repair, AP site formation (GO:0006285)3.63025700
26protein targeting to ER (GO:0045047)3.62744543
27somite rostral/caudal axis specification (GO:0032525)3.58208196
28synaptonemal complex organization (GO:0070193)3.57105499
29regulation of MHC class II biosynthetic process (GO:0045346)3.55383276
30cellular protein complex disassembly (GO:0043624)3.53245846
31male meiosis (GO:0007140)3.49701261
32negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.49155315
33negative regulation of T-helper cell differentiation (GO:0045623)3.49155315
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.48846198
35meiosis I (GO:0007127)3.47878335
36establishment of protein localization to endoplasmic reticulum (GO:0072599)3.43091922
37translational elongation (GO:0006414)3.42934281
38neuron fate determination (GO:0048664)3.42464409
39protein localization to endoplasmic reticulum (GO:0070972)3.35899673
40neuronal stem cell maintenance (GO:0097150)3.35630294
41urogenital system development (GO:0001655)3.34423700
42resolution of meiotic recombination intermediates (GO:0000712)3.29119674
43CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.28405920
44T-helper cell differentiation (GO:0042093)3.28405920
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27992405
46sister chromatid cohesion (GO:0007062)3.27006629
47DNA methylation involved in gamete generation (GO:0043046)3.26461430
48regulation of cilium movement (GO:0003352)3.23597743
49primitive streak formation (GO:0090009)3.16730557
50positive regulation of chemokine biosynthetic process (GO:0045080)3.16673828
51negative regulation of alpha-beta T cell activation (GO:0046636)3.16172798
52meiotic cell cycle process (GO:1903046)3.14920779
53regulation of hair follicle development (GO:0051797)3.14476599
54T cell differentiation involved in immune response (GO:0002292)3.14465118
55alpha-beta T cell differentiation involved in immune response (GO:0002293)3.14465118
56alpha-beta T cell activation involved in immune response (GO:0002287)3.14465118
57hematopoietic stem cell proliferation (GO:0071425)3.14281430
58positive regulation of granulocyte differentiation (GO:0030854)3.10679053
59viral life cycle (GO:0019058)3.09289673
60negative regulation of alpha-beta T cell differentiation (GO:0046639)3.08377971
61meiotic nuclear division (GO:0007126)3.07653474
62reciprocal meiotic recombination (GO:0007131)3.02567136
63reciprocal DNA recombination (GO:0035825)3.02567136
64myelin assembly (GO:0032288)3.00638749
65inner mitochondrial membrane organization (GO:0007007)2.98331327
66histone-serine phosphorylation (GO:0035404)2.98187861
67protein complex disassembly (GO:0043241)2.95913476
68defense response to protozoan (GO:0042832)2.94840791
69regulation of immunoglobulin secretion (GO:0051023)2.94715066
70gene silencing by RNA (GO:0031047)2.90069175
71interkinetic nuclear migration (GO:0022027)2.88166065
72pyrimidine nucleotide catabolic process (GO:0006244)2.86615453
73positive regulation of isotype switching (GO:0045830)2.85600321
74macromolecular complex disassembly (GO:0032984)2.84683746
75intraciliary transport (GO:0042073)2.84656823
76CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.84075552
77organelle disassembly (GO:1903008)2.82485286
78positive regulation of DNA recombination (GO:0045911)2.80458312
79thalamus development (GO:0021794)2.77231489
80histone H3-K9 demethylation (GO:0033169)2.76987598
81ribosomal large subunit biogenesis (GO:0042273)2.76554512
82translational initiation (GO:0006413)2.72508535
83positive regulation of developmental pigmentation (GO:0048087)2.71690924
84tongue development (GO:0043586)2.69618974
85regulation of granulocyte differentiation (GO:0030852)2.69021795
86alpha-beta T cell differentiation (GO:0046632)2.66406312
87regulation of hair cycle (GO:0042634)2.60859088
88CD4-positive, alpha-beta T cell activation (GO:0035710)2.60812250
89positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.58616782
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.57920952
91protein complex biogenesis (GO:0070271)2.57691245
92positive regulation of neurological system process (GO:0031646)2.56540346
93mitotic sister chromatid cohesion (GO:0007064)2.56434133
94histone H3-K4 trimethylation (GO:0080182)2.55866009
95regulation of microtubule-based movement (GO:0060632)2.54842978
96positive regulation of DNA-templated transcription, initiation (GO:2000144)2.54039087
97ribosomal small subunit biogenesis (GO:0042274)2.53009894
98retinal cone cell development (GO:0046549)2.51795175
99regulation of pigment cell differentiation (GO:0050932)2.51716778
100response to protozoan (GO:0001562)2.50821400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.75606666
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.48409258
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.09585910
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.97113079
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.87372977
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58272968
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54466994
8ZNF274_21170338_ChIP-Seq_K562_Hela2.36025188
9EWS_26573619_Chip-Seq_HEK293_Human2.23221900
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18739650
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16987292
12FUS_26573619_Chip-Seq_HEK293_Human2.12231874
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02551742
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.94258264
15VDR_22108803_ChIP-Seq_LS180_Human1.92223815
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92136772
17TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91683411
18POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.91683411
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.91499006
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91487759
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.91076137
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88515062
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.79847680
24P300_19829295_ChIP-Seq_ESCs_Human1.79123610
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75833214
26IGF1R_20145208_ChIP-Seq_DFB_Human1.72529683
27ER_23166858_ChIP-Seq_MCF-7_Human1.72273821
28GBX2_23144817_ChIP-Seq_PC3_Human1.71036807
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63228995
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61465200
31IRF1_19129219_ChIP-ChIP_H3396_Human1.61462534
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.59360198
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58742807
34TAF15_26573619_Chip-Seq_HEK293_Human1.58284751
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56886580
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56869303
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53892114
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50741194
39RNF2_27304074_Chip-Seq_NSC_Mouse1.50171645
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49507462
41STAT3_23295773_ChIP-Seq_U87_Human1.47845577
42TCF4_23295773_ChIP-Seq_U87_Human1.44392970
43PRDM14_20953172_ChIP-Seq_ESCs_Human1.43342483
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43324092
45CBP_20019798_ChIP-Seq_JUKART_Human1.42386990
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42386990
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.42323782
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40208540
49SMAD4_21799915_ChIP-Seq_A2780_Human1.39647634
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.39426440
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37425437
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36742951
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36172938
54TP53_16413492_ChIP-PET_HCT116_Human1.35570104
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.35386674
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35033277
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32506135
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32506135
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32506135
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31988107
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31927793
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.31814039
63RUNX_20019798_ChIP-Seq_JUKART_Human1.27278515
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25094295
65CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.24571077
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.23631515
67AR_25329375_ChIP-Seq_VCAP_Human1.23083740
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22167074
69VDR_23849224_ChIP-Seq_CD4+_Human1.20893516
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18509642
71ELK1_19687146_ChIP-ChIP_HELA_Human1.17014750
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16484548
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.13949511
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.13348444
75TCF4_22108803_ChIP-Seq_LS180_Human1.12872466
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.12494620
77ERG_20517297_ChIP-Seq_VCAP_Human1.11690481
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09352248
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.08815838
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07771558
81BCAT_22108803_ChIP-Seq_LS180_Human1.07258463
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07169617
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.05460885
84TP53_22573176_ChIP-Seq_HFKS_Human1.05369877
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04490562
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03517590
87SOX2_19829295_ChIP-Seq_ESCs_Human1.03023169
88NANOG_19829295_ChIP-Seq_ESCs_Human1.03023169
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.02914470
90RUNX2_22187159_ChIP-Seq_PCA_Human1.02587235
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02362323
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02289561
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.02289561
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01841039
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.00308448
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00219957
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98705499
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98598793
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98585734
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96689424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.82698743
2MP0000569_abnormal_digit_pigmentation3.71990944
3MP0008057_abnormal_DNA_replication3.65133979
4MP0008877_abnormal_DNA_methylation3.47670708
5MP0008058_abnormal_DNA_repair3.26040165
6MP0006292_abnormal_olfactory_placode3.24683164
7MP0003890_abnormal_embryonic-extraembry2.78562297
8MP0010030_abnormal_orbit_morphology2.51412814
9MP0002928_abnormal_bile_duct2.28111123
10MP0006072_abnormal_retinal_apoptosis2.22804760
11MP0003283_abnormal_digestive_organ2.18655192
12MP0006082_CNS_inflammation2.08387909
13MP0004142_abnormal_muscle_tone2.06545865
14MP0001835_abnormal_antigen_presentation2.02663367
15MP0003195_calcinosis1.94467084
16MP0008995_early_reproductive_senescence1.88357482
17MP0005310_abnormal_salivary_gland1.78704345
18MP0005671_abnormal_response_to1.78538991
19MP0002210_abnormal_sex_determination1.74686545
20MP0003136_yellow_coat_color1.70981377
21MP0004742_abnormal_vestibular_system1.70650255
22MP0001800_abnormal_humoral_immune1.70079586
23MP0008004_abnormal_stomach_pH1.70060450
24MP0000566_synostosis1.63671496
25MP0000383_abnormal_hair_follicle1.62829669
26MP0003646_muscle_fatigue1.61869252
27MP0002277_abnormal_respiratory_mucosa1.60383079
28MP0001929_abnormal_gametogenesis1.59103382
29MP0003303_peritoneal_inflammation1.58510830
30MP0002653_abnormal_ependyma_morphology1.58313284
31MP0005551_abnormal_eye_electrophysiolog1.46639916
32MP0000427_abnormal_hair_cycle1.46570471
33MP0008789_abnormal_olfactory_epithelium1.46454273
34MP0001986_abnormal_taste_sensitivity1.46320754
35MP0000778_abnormal_nervous_system1.45267190
36MP0003315_abnormal_perineum_morphology1.40265541
37MP0001293_anophthalmia1.38186064
38MP0005253_abnormal_eye_physiology1.37051922
39MP0005084_abnormal_gallbladder_morpholo1.33109600
40MP0001348_abnormal_lacrimal_gland1.31420045
41MP0001790_abnormal_immune_system1.30909293
42MP0005387_immune_system_phenotype1.30909293
43MP0001873_stomach_inflammation1.30517054
44MP0001346_abnormal_lacrimal_gland1.28626463
45MP0008875_abnormal_xenobiotic_pharmacok1.28034748
46MP0003656_abnormal_erythrocyte_physiolo1.27957024
47MP0005000_abnormal_immune_tolerance1.26296788
48MP0003718_maternal_effect1.24701614
49MP0000653_abnormal_sex_gland1.21572512
50MP0002837_dystrophic_cardiac_calcinosis1.20730981
51MP0003698_abnormal_male_reproductive1.19747411
52MP0002148_abnormal_hypersensitivity_rea1.16893138
53MP0001145_abnormal_male_reproductive1.13690055
54MP0004381_abnormal_hair_follicle1.12859527
55MP0005499_abnormal_olfactory_system1.11463149
56MP0005394_taste/olfaction_phenotype1.11463149
57MP0003252_abnormal_bile_duct1.11266394
58MP0002095_abnormal_skin_pigmentation1.09184907
59MP0005174_abnormal_tail_pigmentation1.08381916
60MP0009785_altered_susceptibility_to1.07695531
61MP0002723_abnormal_immune_serum1.02360402
62MP0002138_abnormal_hepatobiliary_system1.01194767
63MP0002102_abnormal_ear_morphology1.01112151
64MP0005391_vision/eye_phenotype0.98575539
65MP0000955_abnormal_spinal_cord0.97591696
66MP0005195_abnormal_posterior_eye0.97428788
67MP0003878_abnormal_ear_physiology0.97109110
68MP0005377_hearing/vestibular/ear_phenot0.97109110
69MP0001119_abnormal_female_reproductive0.96447924
70MP0005646_abnormal_pituitary_gland0.96267987
71MP0002452_abnormal_antigen_presenting0.95442812
72MP0000631_abnormal_neuroendocrine_gland0.95012766
73MP0005645_abnormal_hypothalamus_physiol0.92808915
74MP0001663_abnormal_digestive_system0.92170596
75MP0005167_abnormal_blood-brain_barrier0.90934142
76MP0004808_abnormal_hematopoietic_stem0.90759528
77MP0003121_genomic_imprinting0.89673206
78MP0002405_respiratory_system_inflammati0.89611995
79MP0008961_abnormal_basal_metabolism0.89080815
80MP0000685_abnormal_immune_system0.87807766
81MP0005389_reproductive_system_phenotype0.87132913
82MP0005025_abnormal_response_to0.84182512
83MP0003699_abnormal_female_reproductive0.84174514
84MP0010094_abnormal_chromosome_stability0.82576708
85MP0001286_abnormal_eye_development0.81808681
86MP0005266_abnormal_metabolism0.81682671
87MP0000026_abnormal_inner_ear0.79434115
88MP0005187_abnormal_penis_morphology0.78190139
89MP0005410_abnormal_fertilization0.76157986
90MP0001919_abnormal_reproductive_system0.75040183
91MP0002751_abnormal_autonomic_nervous0.74941760
92MP0002160_abnormal_reproductive_system0.74065375
93MP0005381_digestive/alimentary_phenotyp0.70390453
94MP0002420_abnormal_adaptive_immunity0.69791414
95MP0001819_abnormal_immune_cell0.69673630
96MP0004133_heterotaxia0.68635533
97MP0005248_abnormal_Harderian_gland0.67729485
98MP0000716_abnormal_immune_system0.67230106
99MP0003763_abnormal_thymus_physiology0.67091632
100MP0002067_abnormal_sensory_capabilities0.66710064

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)5.56011578
2Abnormal respiratory epithelium morphology (HP:0012253)5.56011578
3Oligodactyly (hands) (HP:0001180)5.42139275
4Abnormal ciliary motility (HP:0012262)4.60646220
5Reticulocytopenia (HP:0001896)4.35885453
6Abnormal respiratory motile cilium physiology (HP:0012261)3.93819922
7Absent/shortened dynein arms (HP:0200106)3.83303931
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.83303931
9Oligodactyly (HP:0012165)3.53204126
10Supernumerary spleens (HP:0009799)3.51256500
11Nephronophthisis (HP:0000090)3.24668194
12Chronic sinusitis (HP:0011109)3.18173222
13Enlarged epiphyses (HP:0010580)3.14485211
14Bronchiectasis (HP:0002110)3.06401456
15Abnormality of midbrain morphology (HP:0002418)2.99743398
16Molar tooth sign on MRI (HP:0002419)2.99743398
17Rhinitis (HP:0012384)2.85964631
18Abnormality of the renal medulla (HP:0100957)2.85909722
19Congenital, generalized hypertrichosis (HP:0004540)2.60979547
20Infertility (HP:0000789)2.57343994
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.57286127
22Medial flaring of the eyebrow (HP:0010747)2.56714754
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.55925739
24Split foot (HP:0001839)2.51111522
252-3 toe syndactyly (HP:0004691)2.51052839
26Abnormality of the phalanges of the 2nd finger (HP:0009541)2.50980274
27Abnormality of cells of the erythroid lineage (HP:0012130)2.50497324
28Ectopic kidney (HP:0000086)2.47241811
293-Methylglutaconic aciduria (HP:0003535)2.46652370
30Pancreatic fibrosis (HP:0100732)2.46081454
31Abnormality of chromosome stability (HP:0003220)2.44688703
32Pancreatic cysts (HP:0001737)2.27809924
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.26118068
34Acute necrotizing encephalopathy (HP:0006965)2.24146642
35Papillary thyroid carcinoma (HP:0002895)2.24016925
36Deep palmar crease (HP:0006191)2.23401104
37Macrocytic anemia (HP:0001972)2.21500265
38Septo-optic dysplasia (HP:0100842)2.18205539
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.14301989
40Tubulointerstitial nephritis (HP:0001970)2.10289778
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04656011
42Type II lissencephaly (HP:0007260)2.02999763
43Thickened helices (HP:0000391)2.01339078
44Absent hand (HP:0004050)2.00497929
45Tubular atrophy (HP:0000092)2.00467899
46Genetic anticipation (HP:0003743)2.00363404
47Stenosis of the external auditory canal (HP:0000402)1.98461649
48Triphalangeal thumb (HP:0001199)1.98294467
49Febrile seizures (HP:0002373)1.98030486
50Congenital stationary night blindness (HP:0007642)1.97541283
51Abnormal number of erythroid precursors (HP:0012131)1.96905431
52Abnormal pancreas size (HP:0012094)1.94504447
53Absent septum pellucidum (HP:0001331)1.93808267
54Hypoplasia of the ulna (HP:0003022)1.92767614
55Impulsivity (HP:0100710)1.92675947
56Abnormality of incisor morphology (HP:0011063)1.92382218
57Duplicated collecting system (HP:0000081)1.90650286
58Optic nerve hypoplasia (HP:0000609)1.88603360
59Chronic hepatic failure (HP:0100626)1.88409527
60Meckel diverticulum (HP:0002245)1.88282897
61Fibular hypoplasia (HP:0003038)1.85926667
62Retrobulbar optic neuritis (HP:0100654)1.85659668
63Optic neuritis (HP:0100653)1.85659668
64Stomach cancer (HP:0012126)1.85283857
65Chronic otitis media (HP:0000389)1.82510023
66Abnormal drinking behavior (HP:0030082)1.81825614
67Polydipsia (HP:0001959)1.81825614
68Abnormality of the septum pellucidum (HP:0007375)1.81673367
69Stomatitis (HP:0010280)1.80897117
70Esophageal atresia (HP:0002032)1.80748497
71Synostosis involving the elbow (HP:0003938)1.80647928
72Humeroradial synostosis (HP:0003041)1.80647928
73Capillary hemangiomas (HP:0005306)1.80299073
74Progressive macrocephaly (HP:0004481)1.79967353
75Azoospermia (HP:0000027)1.78848140
76Abnormal mitochondria in muscle tissue (HP:0008316)1.78377755
77Aplasia/Hypoplasia of the ulna (HP:0006495)1.76966726
78Chromsome breakage (HP:0040012)1.76440921
79Abnormality of the renal cortex (HP:0011035)1.76406343
80Partial agenesis of the corpus callosum (HP:0001338)1.76302347
81Abnormality of the pons (HP:0007361)1.75599930
82Congenital hepatic fibrosis (HP:0002612)1.75484800
83Abnormality of the ileum (HP:0001549)1.75236145
84Tubulointerstitial abnormality (HP:0001969)1.73207117
85Small intestinal stenosis (HP:0012848)1.73015599
86Duodenal stenosis (HP:0100867)1.73015599
87Aqueductal stenosis (HP:0002410)1.72453663
88Cerebellar dysplasia (HP:0007033)1.71206785
89Gait imbalance (HP:0002141)1.69925330
90Congenital primary aphakia (HP:0007707)1.69913662
91Acute encephalopathy (HP:0006846)1.69871162
92Hypoplastic iliac wings (HP:0002866)1.69168197
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.69166236
94Mitochondrial inheritance (HP:0001427)1.68973288
95Colon cancer (HP:0003003)1.68665022
96Neoplasm of the tracheobronchial system (HP:0100552)1.68211257
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67568211
98Degeneration of the lateral corticospinal tracts (HP:0002314)1.67568211
99Poor coordination (HP:0002370)1.67162011
100Abnormality of the renal collecting system (HP:0004742)1.66562169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.45120798
2KSR13.02850090
3STK162.93873099
4ACVR1B2.46416959
5PBK2.30055379
6EPHB22.29603765
7STK242.27877258
8BMPR1B2.15331750
9NLK2.04126005
10AKT32.01368626
11BRAF1.84796859
12DAPK21.84108103
13BRD41.82911445
14PLK41.80110135
15FRK1.74167852
16MAPK151.68822286
17CAMK1G1.67542417
18VRK11.67197975
19STK38L1.58109608
20MAP3K91.56847064
21TAOK31.50278107
22RAF11.44412687
23IKBKE1.44222203
24DMPK1.40627328
25IRAK11.40150763
26CAMKK21.37993937
27NUAK11.37446450
28TEC1.36441267
29WNK11.35212415
30TGFBR11.34939358
31GRK11.34080247
32PIK3CG1.33877948
33FGR1.33032667
34BRSK21.30893160
35ZAK1.30818359
36DYRK31.30251765
37MAP3K121.25618257
38TXK1.20922624
39KSR21.20414131
40IRAK41.19077080
41CDK81.18392384
42STK41.14656386
43CDK121.12401016
44SGK21.11934706
45ADRBK21.09944104
46PLK21.07828927
47SRPK11.04931472
48ITK1.01220017
49BTK0.98671729
50PAK30.95156616
51IKBKB0.94505771
52IRAK20.91660607
53CAMK1D0.89772997
54BLK0.88646152
55ERBB20.88609047
56BMPR20.87395399
57MAP3K40.84989311
58MAP2K40.82071198
59STK110.81312324
60WEE10.80450105
61MAP3K130.77094275
62CHUK0.75008552
63GRK70.74663604
64MATK0.73013984
65MAP4K10.72266811
66PIM10.70597422
67TYK20.68555235
68SGK2230.66675476
69SGK4940.66675476
70MARK30.66368411
71TNIK0.65315983
72PTK2B0.63849333
73FGFR20.62068664
74MOS0.57229342
75CCNB10.56300346
76MELK0.55383326
77SGK10.55304506
78PIK3CA0.55006774
79MAP2K70.54997045
80PDGFRB0.53202534
81DYRK20.53193985
82PASK0.53103023
83SGK30.52850204
84LYN0.51560256
85PLK30.50516689
86DYRK1A0.50049996
87NEK60.48813578
88LRRK20.44573504
89OBSCN0.44379775
90SYK0.43992463
91NEK90.43070535
92ATR0.40468149
93MAPK130.39562495
94LCK0.36581455
95ADRBK10.35674553
96WNK30.34869516
97ATM0.33985676
98TSSK60.33917510
99CAMK10.32878906
100JAK30.31524358

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.84657090
2Asthma_Homo sapiens_hsa053103.64269402
3Allograft rejection_Homo sapiens_hsa053303.25813046
4Autoimmune thyroid disease_Homo sapiens_hsa053202.90914989
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.77488648
6Oxidative phosphorylation_Homo sapiens_hsa001902.71205491
7Protein export_Homo sapiens_hsa030602.33016003
8Parkinsons disease_Homo sapiens_hsa050122.24680881
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23424988
10Homologous recombination_Homo sapiens_hsa034401.91062240
11Huntingtons disease_Homo sapiens_hsa050161.82979600
12Fanconi anemia pathway_Homo sapiens_hsa034601.82716105
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.81735820
14Non-homologous end-joining_Homo sapiens_hsa034501.80467008
15Graft-versus-host disease_Homo sapiens_hsa053321.71999634
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70291292
17Cardiac muscle contraction_Homo sapiens_hsa042601.56293361
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47823263
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47816297
20Leishmaniasis_Homo sapiens_hsa051401.43142603
21Rheumatoid arthritis_Homo sapiens_hsa053231.41366102
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36354522
23Basal transcription factors_Homo sapiens_hsa030221.36103340
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36090877
25Systemic lupus erythematosus_Homo sapiens_hsa053221.31132352
26T cell receptor signaling pathway_Homo sapiens_hsa046601.24937833
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.24333242
28Alzheimers disease_Homo sapiens_hsa050101.23210869
29Basal cell carcinoma_Homo sapiens_hsa052171.23139680
30Measles_Homo sapiens_hsa051621.19254764
31Type I diabetes mellitus_Homo sapiens_hsa049401.18654705
32Dorso-ventral axis formation_Homo sapiens_hsa043201.17918827
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17867416
34Hedgehog signaling pathway_Homo sapiens_hsa043401.17372035
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16971008
36RNA polymerase_Homo sapiens_hsa030201.10860023
37Staphylococcus aureus infection_Homo sapiens_hsa051501.08742938
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06781383
39Collecting duct acid secretion_Homo sapiens_hsa049661.02828771
40Influenza A_Homo sapiens_hsa051641.02709401
41RNA degradation_Homo sapiens_hsa030180.99352926
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.98208655
43Hematopoietic cell lineage_Homo sapiens_hsa046400.93745606
44Mismatch repair_Homo sapiens_hsa034300.92475697
45Osteoclast differentiation_Homo sapiens_hsa043800.91794259
46Caffeine metabolism_Homo sapiens_hsa002320.81547237
47Legionellosis_Homo sapiens_hsa051340.81424367
48Nucleotide excision repair_Homo sapiens_hsa034200.79868180
49Nicotine addiction_Homo sapiens_hsa050330.78902550
50Cell cycle_Homo sapiens_hsa041100.77363877
51TGF-beta signaling pathway_Homo sapiens_hsa043500.75088101
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73809397
53Circadian rhythm_Homo sapiens_hsa047100.73692937
54Notch signaling pathway_Homo sapiens_hsa043300.73057971
55TNF signaling pathway_Homo sapiens_hsa046680.72943660
56Tuberculosis_Homo sapiens_hsa051520.72661275
57Linoleic acid metabolism_Homo sapiens_hsa005910.72103103
58B cell receptor signaling pathway_Homo sapiens_hsa046620.70692226
59Prolactin signaling pathway_Homo sapiens_hsa049170.69508924
60Malaria_Homo sapiens_hsa051440.64999531
61Proteasome_Homo sapiens_hsa030500.64737344
62Phototransduction_Homo sapiens_hsa047440.63613124
63African trypanosomiasis_Homo sapiens_hsa051430.60448311
64Nitrogen metabolism_Homo sapiens_hsa009100.56992219
65MAPK signaling pathway_Homo sapiens_hsa040100.56099167
66Olfactory transduction_Homo sapiens_hsa047400.56012094
67Chemokine signaling pathway_Homo sapiens_hsa040620.54902989
68DNA replication_Homo sapiens_hsa030300.54687132
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54440307
70Epstein-Barr virus infection_Homo sapiens_hsa051690.50817179
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.50340163
72HTLV-I infection_Homo sapiens_hsa051660.50276703
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49893074
74Hepatitis B_Homo sapiens_hsa051610.49302342
75Herpes simplex infection_Homo sapiens_hsa051680.49169097
76FoxO signaling pathway_Homo sapiens_hsa040680.48245596
77Base excision repair_Homo sapiens_hsa034100.48151633
78Primary immunodeficiency_Homo sapiens_hsa053400.47820693
79Spliceosome_Homo sapiens_hsa030400.46072864
80Pertussis_Homo sapiens_hsa051330.43922349
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43641927
82Alcoholism_Homo sapiens_hsa050340.42264577
83Toxoplasmosis_Homo sapiens_hsa051450.40595555
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38496761
85Wnt signaling pathway_Homo sapiens_hsa043100.37863509
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.37353439
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36984621
88Antigen processing and presentation_Homo sapiens_hsa046120.36688668
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35729393
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32605773
91Oxytocin signaling pathway_Homo sapiens_hsa049210.32417299
92Viral carcinogenesis_Homo sapiens_hsa052030.32367913
93RNA transport_Homo sapiens_hsa030130.31187867
94Regulation of autophagy_Homo sapiens_hsa041400.30652364
95Colorectal cancer_Homo sapiens_hsa052100.27014265
96Cholinergic synapse_Homo sapiens_hsa047250.26586997
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.26420872
98Phagosome_Homo sapiens_hsa041450.26085648
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25306699
100Hepatitis C_Homo sapiens_hsa051600.24086045

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