OTUD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)7.28789059
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.74694214
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.74694214
4positive regulation of gamma-delta T cell activation (GO:0046645)4.49531376
5antigen processing and presentation of endogenous antigen (GO:0019883)4.43477999
6regulation of gamma-delta T cell differentiation (GO:0045586)4.43193393
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.26889067
8negative regulation of cell killing (GO:0031342)4.26889067
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.25654346
10positive regulation of histone deacetylation (GO:0031065)4.15577380
11pre-miRNA processing (GO:0031054)3.96035462
12regulation of gamma-delta T cell activation (GO:0046643)3.91342663
13positive thymic T cell selection (GO:0045059)3.73424625
14response to muramyl dipeptide (GO:0032495)3.70678385
15response to interleukin-15 (GO:0070672)3.57285992
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.56522484
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.56522484
18modulation by symbiont of host immune response (GO:0052553)3.56522484
19positive regulation by symbiont of host defense response (GO:0052509)3.56522484
20modulation by symbiont of host defense response (GO:0052031)3.56522484
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.56522484
22mannose metabolic process (GO:0006013)3.33124441
23detection of bacterium (GO:0016045)3.32912155
24negative regulation of histone methylation (GO:0031061)3.32895511
25thymic T cell selection (GO:0045061)3.28049925
26detection of other organism (GO:0098543)3.25345282
27regulation of interleukin-12 biosynthetic process (GO:0045075)3.24281760
28JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.21123597
29neutrophil activation involved in immune response (GO:0002283)3.18785596
30response to peptidoglycan (GO:0032494)3.18474718
31negative T cell selection (GO:0043383)3.17489728
32negative thymic T cell selection (GO:0045060)3.15470874
33germinal center formation (GO:0002467)3.14928843
34modulation by virus of host process (GO:0019054)3.14558760
35modulation by symbiont of host cellular process (GO:0044068)3.13038684
36leukocyte aggregation (GO:0070486)3.11692570
37negative regulation of erythrocyte differentiation (GO:0045647)3.10188717
38dosage compensation (GO:0007549)3.09769896
39natural killer cell differentiation (GO:0001779)3.09737293
40cytoplasmic mRNA processing body assembly (GO:0033962)3.06097569
41negative regulation of leukocyte mediated immunity (GO:0002704)3.04558327
42T cell selection (GO:0045058)3.04372981
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.04200509
44peptidyl-lysine dimethylation (GO:0018027)3.02834444
45positive regulation of protein deacetylation (GO:0090312)3.02530866
46signal complex assembly (GO:0007172)3.02310917
47regulation of T-helper 2 cell differentiation (GO:0045628)3.02274483
48cellular response to interleukin-15 (GO:0071350)2.98291669
49negative regulation of lymphocyte mediated immunity (GO:0002707)2.95431092
50positive T cell selection (GO:0043368)2.92524594
51trophectodermal cell differentiation (GO:0001829)2.86418904
52regulation of leukocyte degranulation (GO:0043300)2.84583235
53regulation of ARF protein signal transduction (GO:0032012)2.84115761
54histone H2A monoubiquitination (GO:0035518)2.84100289
55NIK/NF-kappaB signaling (GO:0038061)2.83793590
56mRNA stabilization (GO:0048255)2.83410171
57RNA stabilization (GO:0043489)2.83410171
58regulation of mast cell degranulation (GO:0043304)2.82734401
59regulation of type I interferon-mediated signaling pathway (GO:0060338)2.82362700
603-UTR-mediated mRNA stabilization (GO:0070935)2.81683978
61cellular response to virus (GO:0098586)2.81508917
62macrophage activation involved in immune response (GO:0002281)2.81345502
63positive regulation of B cell differentiation (GO:0045579)2.81243391
64maternal placenta development (GO:0001893)2.79192704
65regulation of early endosome to late endosome transport (GO:2000641)2.77595333
66regulation of natural killer cell mediated immunity (GO:0002715)2.73774736
67regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.73774736
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73618407
69growth hormone receptor signaling pathway (GO:0060396)2.71329410
70lipopolysaccharide-mediated signaling pathway (GO:0031663)2.70707876
71hepatocyte apoptotic process (GO:0097284)2.69999936
72regulation of defense response to virus by virus (GO:0050690)2.68975754
73negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68803850
74tolerance induction (GO:0002507)2.68255718
75regulation of myeloid leukocyte mediated immunity (GO:0002886)2.67762192
76regulation of RNA export from nucleus (GO:0046831)2.67089898
77erythrocyte maturation (GO:0043249)2.65122234
78negative regulation of T cell mediated immunity (GO:0002710)2.64978472
79detection of external biotic stimulus (GO:0098581)2.64410195
80regulation of erythrocyte differentiation (GO:0045646)2.63242553
81regulation of T cell tolerance induction (GO:0002664)2.62950171
82B cell receptor signaling pathway (GO:0050853)2.61086855
83L-alpha-amino acid transmembrane transport (GO:1902475)2.60895327
84intracellular estrogen receptor signaling pathway (GO:0030520)2.60746099
85negative regulation of innate immune response (GO:0045824)2.60429760
86heterochromatin organization (GO:0070828)2.58068914
87positive regulation of erythrocyte differentiation (GO:0045648)2.56593579
88immunoglobulin mediated immune response (GO:0016064)2.54909338
89positive regulation of Rap GTPase activity (GO:0032854)2.54725921
90negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54352949
91positive regulation of gene expression, epigenetic (GO:0045815)2.54231635
92Peyers patch development (GO:0048541)2.53725691
93mucosal-associated lymphoid tissue development (GO:0048537)2.53725691
94regulation of interferon-beta biosynthetic process (GO:0045357)2.53654031
95regulation of chromatin binding (GO:0035561)2.52894578
96antigen processing and presentation via MHC class Ib (GO:0002475)2.52694079
97negative regulation of toll-like receptor signaling pathway (GO:0034122)2.52200544
98chromatin assembly (GO:0031497)2.51786849
99histone H3-K9 demethylation (GO:0033169)2.50349350
100negative regulation of cytokine production involved in immune response (GO:0002719)2.50073365
101NLS-bearing protein import into nucleus (GO:0006607)2.48946714
102B cell homeostasis (GO:0001782)2.48079561
103positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.47900874
104regulation of histone H3-K27 methylation (GO:0061085)2.47060009
105negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.46914926
106positive regulation of Cdc42 GTPase activity (GO:0043089)2.45883497
107regulation of regulated secretory pathway (GO:1903305)2.45584514
108activation of MAPKKK activity (GO:0000185)2.44756511
109response to laminar fluid shear stress (GO:0034616)2.44403835
110cytoskeletal anchoring at plasma membrane (GO:0007016)2.42517861
111T cell costimulation (GO:0031295)2.42226874
112granulocyte activation (GO:0036230)2.41877241
113regulation of B cell differentiation (GO:0045577)2.41872239
114megakaryocyte development (GO:0035855)2.40776765
115regulation of B cell receptor signaling pathway (GO:0050855)2.40116642
116glucocorticoid receptor signaling pathway (GO:0042921)2.39486283
117positive regulation of cellular amide metabolic process (GO:0034250)2.39471059
118negative regulation of RNA splicing (GO:0033119)2.38799041
119negative regulation of type 2 immune response (GO:0002829)2.37622468
120cellular response to growth hormone stimulus (GO:0071378)2.37265410
121regulation of nucleobase-containing compound transport (GO:0032239)2.36699286
122regulation of mast cell activation involved in immune response (GO:0033006)2.36652115
123neutrophil activation (GO:0042119)2.36283680
124regulation of interleukin-2 biosynthetic process (GO:0045076)2.35683823
125protoporphyrinogen IX metabolic process (GO:0046501)2.35492464
126corticosteroid receptor signaling pathway (GO:0031958)2.35427710
127lymphocyte costimulation (GO:0031294)2.35387484
128response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.35154785
129response to host (GO:0075136)2.35154785
130response to host defenses (GO:0052200)2.35154785
131myeloid dendritic cell differentiation (GO:0043011)2.34803295
132response to type I interferon (GO:0034340)2.34439585
133N-acetylneuraminate metabolic process (GO:0006054)2.33837381
134negative regulation of viral release from host cell (GO:1902187)2.33566374
135regulation of alpha-beta T cell proliferation (GO:0046640)2.32912322
136response to UV-C (GO:0010225)2.32594039
137activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.31522795
138regulation of translational termination (GO:0006449)2.31305979
139T cell migration (GO:0072678)2.30404817
140regulation of ARF GTPase activity (GO:0032312)2.30299984
141regulation of translational fidelity (GO:0006450)2.30028345
142positive regulation of nuclease activity (GO:0032075)2.29454348
143histone H3-K36 demethylation (GO:0070544)2.29167467
144activation of JUN kinase activity (GO:0007257)2.28323574
145negative regulation of bone resorption (GO:0045779)2.28260615
146embryonic process involved in female pregnancy (GO:0060136)2.27434221
147histone H3-K4 methylation (GO:0051568)2.27346459
148interferon-gamma secretion (GO:0072643)2.25772727
149protein localization to endosome (GO:0036010)2.25200407
150positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.23459978
151morphogenesis of an endothelium (GO:0003159)2.22935226
152endothelial tube morphogenesis (GO:0061154)2.22935226
153negative regulation of histone modification (GO:0031057)2.22316238
154cellular response to type I interferon (GO:0071357)2.22261647
155type I interferon signaling pathway (GO:0060337)2.22261647
156mitotic G1 DNA damage checkpoint (GO:0031571)2.21797523
157negative regulation of interleukin-12 production (GO:0032695)2.21715578
158cortical actin cytoskeleton organization (GO:0030866)2.19963737
159histone H4-K16 acetylation (GO:0043984)2.19786526
160nucleosome disassembly (GO:0006337)2.19340899
161protein-DNA complex disassembly (GO:0032986)2.19340899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.07464634
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.77785831
3E2F7_22180533_ChIP-Seq_HELA_Human3.66873675
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.56622486
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.24550059
6VDR_21846776_ChIP-Seq_THP-1_Human2.98609904
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.86787851
8TCF7_22412390_ChIP-Seq_EML_Mouse2.62545790
9KDM2B_26808549_Chip-Seq_DND41_Human2.52066801
10KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.48573654
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.38156174
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.32910756
13MAF_26560356_Chip-Seq_TH1_Human2.30126282
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28127772
15UTX_26944678_Chip-Seq_JUKART_Human2.11769568
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.04817326
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01707345
18GATA1_22025678_ChIP-Seq_K562_Human2.00359298
19SCL_19346495_ChIP-Seq_HPC-7_Human1.97552536
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96317385
21* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93748267
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92800254
23* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.91974849
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85376083
25MYB_26560356_Chip-Seq_TH2_Human1.82253264
26VDR_24763502_ChIP-Seq_THP-1_Human1.79087548
27MYB_26560356_Chip-Seq_TH1_Human1.78409949
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78105718
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67016534
30KDM2B_26808549_Chip-Seq_JURKAT_Human1.66219892
31LXR_22292898_ChIP-Seq_THP-1_Human1.64397377
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64248395
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64165384
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62221197
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61533503
36* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59204196
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58380848
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58216708
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.57119377
40GATA1_19941826_ChIP-Seq_K562_Human1.55987392
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55627575
42CIITA_25753668_ChIP-Seq_RAJI_Human1.55524099
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55378461
44MAF_26560356_Chip-Seq_TH2_Human1.54438255
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50903821
46* NCOR1_26117541_ChIP-Seq_K562_Human1.50673285
47* SA1_27219007_Chip-Seq_ERYTHROID_Human1.47716540
48RUNX_20019798_ChIP-Seq_JUKART_Human1.47071156
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45378784
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.44755234
51RACK7_27058665_Chip-Seq_MCF-7_Human1.42904484
52* GATA1_19941827_ChIP-Seq_MEL_Mouse1.42661131
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42604322
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41853052
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39314125
56* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39108524
57SPI1_23127762_ChIP-Seq_K562_Human1.36827317
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.36750885
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36725698
60KDM2B_26808549_Chip-Seq_K562_Human1.34775858
61ZNF263_19887448_ChIP-Seq_K562_Human1.34477740
62* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34330311
63SMC4_20622854_ChIP-Seq_HELA_Human1.33035212
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.32750015
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.30995265
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30989010
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29168599
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28768465
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28750842
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28598297
71* BCOR_27268052_Chip-Seq_Bcells_Human1.28227789
72* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27498682
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26312241
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.25701950
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24533901
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23107643
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22347841
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21856060
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21384303
80* BCL6_27268052_Chip-Seq_Bcells_Human1.19812583
81ATF3_27146783_Chip-Seq_COLON_Human1.19014742
82* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18566961
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18270415
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15924653
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15440220
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15230530
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15151547
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14413695
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14284701
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13792847
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13537440
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13210188
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12997339
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11164293
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11138685
96CREB1_26743006_Chip-Seq_LNCaP_Human1.10905511
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10660157
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10189642
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09889584
100SPI1_23547873_ChIP-Seq_NB4_Human1.08996064
101CLOCK_20551151_ChIP-Seq_293T_Human1.08447490
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06979120
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06854725
104GATA3_27048872_Chip-Seq_THYMUS_Human1.06468442
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06231472
106E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05757110
107TFEB_21752829_ChIP-Seq_HELA_Human1.05702379
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05601861
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.04833627
110BP1_19119308_ChIP-ChIP_Hs578T_Human1.04612033
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.03767338
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03501590
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03179426
114KDM5A_27292631_Chip-Seq_BREAST_Human1.02549854
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02533914
116GATA6_25053715_ChIP-Seq_YYC3_Human1.02187039
117* P68_20966046_ChIP-Seq_HELA_Human1.01932759
118CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01751118
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01064780
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00606853
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99643118
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98576366
123CHD1_26751641_Chip-Seq_LNCaP_Human0.96767331
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96632588
125MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95937745
126* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95888083
127* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93117994
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92984746
129ELF1_20517297_ChIP-Seq_JURKAT_Human0.92486958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.19784906
2MP0003300_gastrointestinal_ulcer3.03777883
3MP0000685_abnormal_immune_system2.94425726
4MP0005076_abnormal_cell_differentiation2.62987448
5MP0009278_abnormal_bone_marrow2.39928909
6MP0001790_abnormal_immune_system2.29590805
7MP0005387_immune_system_phenotype2.29590805
8MP0003705_abnormal_hypodermis_morpholog2.29456590
9MP0003724_increased_susceptibility_to2.27775196
10MP0001800_abnormal_humoral_immune2.25533942
11MP0008260_abnormal_autophagy2.20849110
12MP0005451_abnormal_body_composition2.19638425
13MP0003656_abnormal_erythrocyte_physiolo2.18638437
14MP0001835_abnormal_antigen_presentation2.16078513
15MP0002398_abnormal_bone_marrow2.13386175
16MP0010352_gastrointestinal_tract_polyps2.06383130
17MP0003436_decreased_susceptibility_to2.06310770
18MP0008961_abnormal_basal_metabolism2.06016440
19MP0003763_abnormal_thymus_physiology2.02166196
20MP0002877_abnormal_melanocyte_morpholog1.96416105
21MP0010234_abnormal_vibrissa_follicle1.95501019
22MP0002396_abnormal_hematopoietic_system1.95413537
23MP0002166_altered_tumor_susceptibility1.95330575
24MP0005397_hematopoietic_system_phenotyp1.92082405
25MP0001545_abnormal_hematopoietic_system1.92082405
26MP0010307_abnormal_tumor_latency1.86614597
27MP0002452_abnormal_antigen_presenting1.85979163
28MP0004947_skin_inflammation1.85973443
29MP0005671_abnormal_response_to1.85186440
30MP0005000_abnormal_immune_tolerance1.83853002
31MP0002420_abnormal_adaptive_immunity1.78793442
32MP0002723_abnormal_immune_serum1.78166626
33MP0001819_abnormal_immune_cell1.78042012
34MP0009333_abnormal_splenocyte_physiolog1.76533472
35MP0004808_abnormal_hematopoietic_stem1.75226644
36MP0000703_abnormal_thymus_morphology1.74800971
37MP0001533_abnormal_skeleton_physiology1.72859181
38MP0002722_abnormal_immune_system1.69212312
39MP0002148_abnormal_hypersensitivity_rea1.68450925
40MP0000716_abnormal_immune_system1.67638660
41MP0000689_abnormal_spleen_morphology1.62594136
42MP0004264_abnormal_extraembryonic_tissu1.62107736
43MP0003566_abnormal_cell_adhesion1.55421031
44MP0003111_abnormal_nucleus_morphology1.53298394
45MP0002405_respiratory_system_inflammati1.52647757
46MP0002006_tumorigenesis1.52490237
47MP0002429_abnormal_blood_cell1.52075451
48MP0010155_abnormal_intestine_physiology1.50154307
49MP0004510_myositis1.49842150
50MP0005464_abnormal_platelet_physiology1.48931671
51MP0004185_abnormal_adipocyte_glucose1.48774160
52MP0005310_abnormal_salivary_gland1.48349280
53MP0009840_abnormal_foam_cell1.44714644
54MP0003172_abnormal_lysosome_physiology1.42886196
55MP0005025_abnormal_response_to1.41878655
56MP0002132_abnormal_respiratory_system1.39754051
57MP0002998_abnormal_bone_remodeling1.39435102
58MP0003077_abnormal_cell_cycle1.33406191
59MP0003693_abnormal_embryo_hatching1.32755985
60MP0003866_abnormal_defecation1.29909478
61MP0001730_embryonic_growth_arrest1.29540942
62MP0002086_abnormal_extraembryonic_tissu1.27478288
63MP0003453_abnormal_keratinocyte_physiol1.27106105
64MP0000350_abnormal_cell_proliferation1.24903870
65MP0004858_abnormal_nervous_system1.23654878
66MP0003828_pulmonary_edema1.21267800
67MP0001348_abnormal_lacrimal_gland1.19853124
68MP0001873_stomach_inflammation1.18417544
69MP0003075_altered_response_to1.17204337
70MP0001849_ear_inflammation1.15760806
71MP0000858_altered_metastatic_potential1.15486822
72MP0002419_abnormal_innate_immunity1.14788601
73MP0000678_abnormal_parathyroid_gland1.13888819
74MP0000490_abnormal_crypts_of1.12705592
75MP0003329_amyloid_beta_deposits1.11900377
76MP0001845_abnormal_inflammatory_respons1.10649239
77MP0003448_altered_tumor_morphology1.10399398
78MP0002019_abnormal_tumor_incidence1.10389905
79MP0001851_eye_inflammation1.09450135
80MP0005666_abnormal_adipose_tissue1.09299661
81MP0001853_heart_inflammation1.08086645
82MP0002254_reproductive_system_inflammat1.05507816
83MP0004197_abnormal_fetal_growth/weight/1.05400302
84MP0004957_abnormal_blastocyst_morpholog1.04738530
85MP0002088_abnormal_embryonic_growth/wei1.01763332
86MP0003984_embryonic_growth_retardation1.01631607
87MP0001672_abnormal_embryogenesis/_devel1.00303188
88MP0005380_embryogenesis_phenotype1.00303188
89MP0005023_abnormal_wound_healing1.00291395
90MP0000465_gastrointestinal_hemorrhage0.99624786
91MP0008469_abnormal_protein_level0.99592140
92MP0009785_altered_susceptibility_to0.99476684
93MP0010094_abnormal_chromosome_stability0.98193552
94MP0002138_abnormal_hepatobiliary_system0.97985609
95MP0001697_abnormal_embryo_size0.97478037
96MP0008874_decreased_physiological_sensi0.96289953
97MP0005409_darkened_coat_color0.95832038
98MP0003091_abnormal_cell_migration0.95785371
99MP0003879_abnormal_hair_cell0.95056560
100MP0004381_abnormal_hair_follicle0.95035133
101MP0003183_abnormal_peptide_metabolism0.93559992
102MP0000313_abnormal_cell_death0.93100529
103MP0002080_prenatal_lethality0.92412955
104MP0003787_abnormal_imprinting0.91721127
105MP0006082_CNS_inflammation0.91561777
106MP0005083_abnormal_biliary_tract0.91150187
107MP0003191_abnormal_cellular_cholesterol0.90184885
108MP0005390_skeleton_phenotype0.88163753
109MP0000733_abnormal_muscle_development0.87049745
110MP0000569_abnormal_digit_pigmentation0.86597494
111MP0005166_decreased_susceptibility_to0.86511261
112* MP0002084_abnormal_developmental_patter0.86169841
113MP0000609_abnormal_liver_physiology0.86039761
114MP0005375_adipose_tissue_phenotype0.85826572
115MP0004859_abnormal_synaptic_plasticity0.85734683
116MP0000604_amyloidosis0.84733793
117MP0005621_abnormal_cell_physiology0.84230208
118MP0001915_intracranial_hemorrhage0.82827444
119MP0003123_paternal_imprinting0.82633877
120MP0002933_joint_inflammation0.82493419
121MP0008057_abnormal_DNA_replication0.81670060
122MP0003045_fibrosis0.81643220
123MP0002909_abnormal_adrenal_gland0.80734902
124MP0001663_abnormal_digestive_system0.80699276
125MP0000003_abnormal_adipose_tissue0.80181939
126MP0008004_abnormal_stomach_pH0.78102246
127MP0003690_abnormal_glial_cell0.77696601
128MP0008770_decreased_survivor_rate0.76868865
129MP0005058_abnormal_lysosome_morphology0.76065732
130MP0003795_abnormal_bone_structure0.75047894
131MP0003279_aneurysm0.70253082
132MP0009931_abnormal_skin_appearance0.69328211
133MP0000343_altered_response_to0.68619526
134MP0000920_abnormal_myelination0.64895687
135MP0005501_abnormal_skin_physiology0.64437802
136MP0002089_abnormal_postnatal_growth/wei0.64394317
137MP0008569_lethality_at_weaning0.64336880

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.75405099
2Recurrent viral infections (HP:0004429)3.39176670
3Abnormality of macrophages (HP:0004311)3.22941402
4Hyperacusis (HP:0010780)3.14143125
5Myositis (HP:0100614)3.04544024
6Abnormal delayed hypersensitivity skin test (HP:0002963)2.99591690
7Obstructive sleep apnea (HP:0002870)2.94891356
8Recurrent fungal infections (HP:0002841)2.94371303
9Colitis (HP:0002583)2.89979124
10Obstructive lung disease (HP:0006536)2.89740757
11Chronic obstructive pulmonary disease (HP:0006510)2.89740757
12Pustule (HP:0200039)2.86057317
13Verrucae (HP:0200043)2.83767067
14Papilloma (HP:0012740)2.83767067
15Basal cell carcinoma (HP:0002671)2.79919637
16Orchitis (HP:0100796)2.78021379
17Gastrointestinal inflammation (HP:0004386)2.77451265
18Panhypogammaglobulinemia (HP:0003139)2.69271910
19Inflammation of the large intestine (HP:0002037)2.66746056
20Cellulitis (HP:0100658)2.66189697
21Cerebral aneurysm (HP:0004944)2.62370927
22Gastrointestinal stroma tumor (HP:0100723)2.61186717
23Gastrointestinal infarctions (HP:0005244)2.59793705
24Autoimmune thrombocytopenia (HP:0001973)2.57944880
25Eczematoid dermatitis (HP:0000976)2.57259924
26Polycythemia (HP:0001901)2.53254671
27T lymphocytopenia (HP:0005403)2.51520861
28Insomnia (HP:0100785)2.51471730
29Chronic otitis media (HP:0000389)2.50923368
30Macroorchidism (HP:0000053)2.50589306
31Optic neuritis (HP:0100653)2.49932983
32Retrobulbar optic neuritis (HP:0100654)2.49932983
33Increased IgE level (HP:0003212)2.49861123
34Dysostosis multiplex (HP:0000943)2.49698364
35Poikilocytosis (HP:0004447)2.47895508
36Nasal polyposis (HP:0100582)2.45915424
37Hypertensive crisis (HP:0100735)2.39423045
38Abnormality of T cell number (HP:0011839)2.35001553
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32834862
40Agammaglobulinemia (HP:0004432)2.32742773
41Abnormality of the nasal mucosa (HP:0000433)2.31478411
42Petechiae (HP:0000967)2.30525600
43Gingivitis (HP:0000230)2.26165683
44Cholecystitis (HP:0001082)2.26095444
45Abnormal gallbladder physiology (HP:0012438)2.26095444
46Ependymoma (HP:0002888)2.22408467
47Epistaxis (HP:0000421)2.19588863
48Spontaneous hematomas (HP:0007420)2.16954111
49Abnormality of T cells (HP:0002843)2.16708524
50Increased cerebral lipofuscin (HP:0011813)2.16702547
51Reticulocytosis (HP:0001923)2.15976800
52Purpura (HP:0000979)2.15451488
53Vertebral compression fractures (HP:0002953)2.14611568
54Poikiloderma (HP:0001029)2.14469383
55Segmental peripheral demyelination/remyelination (HP:0003481)2.12541138
56Ulnar bowing (HP:0003031)2.12352018
57Slow saccadic eye movements (HP:0000514)2.11790612
58IgM deficiency (HP:0002850)2.09700660
59Abnormality of liposaccharide metabolism (HP:0010968)2.09272427
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.09272427
61Abnormality of glycolipid metabolism (HP:0010969)2.09272427
62Recurrent bronchitis (HP:0002837)2.07275358
63Polygenic inheritance (HP:0010982)2.05909676
64Hematochezia (HP:0002573)2.05584439
65Supranuclear gaze palsy (HP:0000605)2.02354587
66Prominent nose (HP:0000448)2.02049934
67Hypochromic anemia (HP:0001931)1.99420119
68Recurrent gram-negative bacterial infections (HP:0005420)1.97902972
69Abnormality of the heme biosynthetic pathway (HP:0010472)1.97277954
70Recurrent skin infections (HP:0001581)1.96585203
71Encephalitis (HP:0002383)1.95621712
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95467353
73Urticaria (HP:0001025)1.94876596
74Chronic mucocutaneous candidiasis (HP:0002728)1.93881463
75Recurrent cutaneous fungal infections (HP:0011370)1.93881463
76Distal lower limb amyotrophy (HP:0008944)1.92404086
77Thin bony cortex (HP:0002753)1.92102383
78Deep palmar crease (HP:0006191)1.91771149
79Fatigue (HP:0012378)1.91155987
80Hand muscle atrophy (HP:0009130)1.90408360
81Pulmonary infiltrates (HP:0002113)1.89733429
82Interstitial pulmonary disease (HP:0006530)1.89162035
83Increased neuronal autofluorescent lipopigment (HP:0002074)1.88879290
84Centrally nucleated skeletal muscle fibers (HP:0003687)1.88707917
85Upper limb amyotrophy (HP:0009129)1.88235863
86Distal upper limb amyotrophy (HP:0007149)1.88235863
87Abnormality of T cell physiology (HP:0011840)1.85984537
88Heterotopia (HP:0002282)1.85910613
89Broad face (HP:0000283)1.84691017
90Emphysema (HP:0002097)1.84162255
91Meningitis (HP:0001287)1.83447119
92Easy fatigability (HP:0003388)1.83181479
93Truncus arteriosus (HP:0001660)1.83132738
94Hemorrhage of the eye (HP:0011885)1.82617131
95Achilles tendon contracture (HP:0001771)1.82388375
96Hypercortisolism (HP:0001578)1.82063586
97Osteomyelitis (HP:0002754)1.81659267
98Myocardial infarction (HP:0001658)1.81510366
99Keratoconjunctivitis sicca (HP:0001097)1.80805403
100Premature loss of primary teeth (HP:0006323)1.80239558
101Prolonged bleeding time (HP:0003010)1.80217590
102Granulocytopenia (HP:0001913)1.79946855
103Protrusio acetabuli (HP:0003179)1.78911930
104Urinary glycosaminoglycan excretion (HP:0003541)1.78399696
105Mucopolysacchariduria (HP:0008155)1.78399696
106Neuronal loss in central nervous system (HP:0002529)1.77890173
107Loss of speech (HP:0002371)1.77634846
108Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76400732
109Abnormality of polysaccharide metabolism (HP:0011012)1.76400732
110Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76400732
111Thoracic kyphosis (HP:0002942)1.75968528
112Aneurysm (HP:0002617)1.75817926
113Pseudobulbar signs (HP:0002200)1.75591279
114Broad palm (HP:0001169)1.75352164
115Arterial thrombosis (HP:0004420)1.75220491
116Chest pain (HP:0100749)1.74884611
117Increased density of long bones (HP:0006392)1.73487303
118Mediastinal lymphadenopathy (HP:0100721)1.73461118
119Long eyelashes (HP:0000527)1.73448577
120Gastrointestinal dysmotility (HP:0002579)1.73446602
121Abnormality of the thoracic spine (HP:0100711)1.73087104
122Recurrent bacterial skin infections (HP:0005406)1.71299135
123Abnormal platelet function (HP:0011869)1.70161834
124Impaired platelet aggregation (HP:0003540)1.70161834
125Mitral valve prolapse (HP:0001634)1.68106145
126Abnormal platelet volume (HP:0011876)1.67763968
127Elfin facies (HP:0004428)1.67597949
128Abnormality of reticulocytes (HP:0004312)1.67209191
129Elevated erythrocyte sedimentation rate (HP:0003565)1.65439315
130Abnormality of the astrocytes (HP:0100707)1.64214686
131Astrocytoma (HP:0009592)1.64214686
132Pointed chin (HP:0000307)1.63690803
133Genu recurvatum (HP:0002816)1.62869372
134Abnormality of the gastric mucosa (HP:0004295)1.61613285
135Combined immunodeficiency (HP:0005387)1.61209810
136Thrombocytosis (HP:0001894)1.60320522
137Enlarged penis (HP:0000040)1.60172307
138Abnormality of oral frenula (HP:0000190)1.59781761
139Disproportionate tall stature (HP:0001519)1.59747792
140Somatic mutation (HP:0001428)1.59606920
141Long palpebral fissure (HP:0000637)1.59093032
142Recurrent abscess formation (HP:0002722)1.58579196
143Abnormality of cells of the lymphoid lineage (HP:0012140)1.58156451
144Gastrointestinal carcinoma (HP:0002672)1.57840242
145Malignant gastrointestinal tract tumors (HP:0006749)1.57840242
146Eosinophilia (HP:0001880)1.57524400
147Skin tags (HP:0010609)1.57466829
148Renal duplication (HP:0000075)1.57192002
149Severe short stature (HP:0003510)1.56769991
150IgA deficiency (HP:0002720)1.54667990
151Vasculitis (HP:0002633)1.54317757
152Viral hepatitis (HP:0006562)1.54249091
153Lymphopenia (HP:0001888)1.54080617
154Hypochromic microcytic anemia (HP:0004840)1.53460982
155Acanthocytosis (HP:0001927)1.53225289
156Renovascular hypertension (HP:0100817)1.52050215
157High pitched voice (HP:0001620)1.51733817
158Spastic diplegia (HP:0001264)1.51265117
159Gingival bleeding (HP:0000225)1.50551766
160Shallow orbits (HP:0000586)1.50418566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.38627995
2PRPF4B3.87614004
3TRIB33.60125092
4EEF2K3.42427274
5CDK123.30342086
6MAP4K13.09386462
7PKN22.76823066
8ERN12.35736209
9SMG12.19819927
10GRK62.06525908
11TYK21.99013765
12STK101.94801583
13JAK31.75002096
14FGFR41.71393496
15PTK61.69048543
16IRAK41.60358026
17TAOK21.56433274
18LRRK21.55316980
19NEK21.54203160
20ALK1.48171459
21ZAP701.46401304
22EPHB11.43550487
23SIK21.42330349
24TAOK11.41407249
25FES1.39862724
26JAK11.39725670
27MAP3K131.30447045
28RIPK11.28187991
29BRD41.26631770
30CDK41.24997555
31TNK21.23744366
32SIK31.20135109
33SCYL21.18284794
34SIK11.18088953
35CDK61.14104077
36MTOR1.10656502
37MAP3K31.10038526
38JAK21.09520855
39BTK1.08331336
40ARAF1.07560504
41FGFR31.03929966
42TBK11.03549998
43KSR21.03395716
44PDGFRA1.02495232
45HCK1.00770019
46PIM11.00124829
47PDPK11.00034137
48MAP3K80.99715789
49STK40.98902320
50CSK0.98893961
51TESK20.96772534
52TAOK30.96384601
53CDK90.95511966
54MAP3K90.93321913
55ICK0.92847824
56ITK0.92503509
57IKBKE0.92306630
58BMX0.91947888
59SYK0.90267452
60BLK0.88462162
61RPS6KB20.88299253
62CAMK1G0.88222661
63MAPK120.87047189
64HIPK20.85932545
65CAMK1D0.85208488
66RPS6KA40.82199887
67MAP3K70.82069518
68IRAK20.81235725
69CHUK0.76839870
70RET0.76723070
71TGFBR20.76070217
72DYRK1B0.75967403
73BMPR20.75451367
74PRKD20.75144820
75TYRO30.74187235
76NME20.74146755
77CAMKK10.74114391
78LCK0.73194968
79FLT30.72756502
80CDC70.70129181
81MARK30.69966784
82MAP3K140.69530492
83PDGFRB0.69515345
84MAP3K110.66845251
85PTK20.66812528
86RPS6KA20.66343132
87IKBKB0.64668263
88PRKCH0.61887876
89RPS6KC10.59571128
90RPS6KL10.59571128
91STK30.59251746
92FGR0.59043317
93MAP3K20.58728487
94BRAF0.57712305
95PAK40.56544516
96MAPKAPK30.56505660
97MAP2K30.54879531
98MELK0.54128744
99RIPK40.51587832
100CSF1R0.49687229
101MARK20.49423757
102MAPK70.48742097
103MAPK110.48592283
104SGK30.48486519
105TLK10.48302240
106IRAK30.47806785
107CHEK10.47014932
108RAF10.46361686
109TTN0.45140728
110MAP2K20.44580858
111KIT0.44216641
112PRKD30.43244877
113CDK20.42050859
114TGFBR10.41746508
115STK110.41704824
116MAP3K10.41499084
117RPS6KA10.41150699
118MAP3K60.40909119
119EGFR0.39433801
120RPS6KA60.39396300
121TXK0.38979789
122CDC42BPA0.38967708
123FYN0.38132998
124PDK10.37524020
125LATS10.36021620
126MATK0.34750788
127LYN0.34410884
128TESK10.34151718
129MOS0.34103220

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.37500138
2B cell receptor signaling pathway_Homo sapiens_hsa046622.27000274
3Chronic myeloid leukemia_Homo sapiens_hsa052202.11431368
4Other glycan degradation_Homo sapiens_hsa005112.09916535
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92520360
6Acute myeloid leukemia_Homo sapiens_hsa052211.83019928
7Antigen processing and presentation_Homo sapiens_hsa046121.82822756
8Osteoclast differentiation_Homo sapiens_hsa043801.79479559
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75062569
10T cell receptor signaling pathway_Homo sapiens_hsa046601.73232518
11Leishmaniasis_Homo sapiens_hsa051401.66123121
12mTOR signaling pathway_Homo sapiens_hsa041501.65552322
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.63169405
14Non-small cell lung cancer_Homo sapiens_hsa052231.61880162
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55013239
16Measles_Homo sapiens_hsa051621.53962336
17Pancreatic cancer_Homo sapiens_hsa052121.47929679
18Toxoplasmosis_Homo sapiens_hsa051451.43149939
19Graft-versus-host disease_Homo sapiens_hsa053321.43076473
20Herpes simplex infection_Homo sapiens_hsa051681.36789803
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36459772
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32552281
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.31323839
24VEGF signaling pathway_Homo sapiens_hsa043701.30514895
25Hepatitis B_Homo sapiens_hsa051611.29795612
26Autoimmune thyroid disease_Homo sapiens_hsa053201.26425296
27Notch signaling pathway_Homo sapiens_hsa043301.26025430
28Lysine degradation_Homo sapiens_hsa003101.24819216
29Small cell lung cancer_Homo sapiens_hsa052221.24628350
30Malaria_Homo sapiens_hsa051441.24367426
31Chemokine signaling pathway_Homo sapiens_hsa040621.24139865
32Prolactin signaling pathway_Homo sapiens_hsa049171.23324923
33Influenza A_Homo sapiens_hsa051641.23256945
34Apoptosis_Homo sapiens_hsa042101.22561379
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.22340013
36Viral carcinogenesis_Homo sapiens_hsa052031.21753062
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.20302120
38Endometrial cancer_Homo sapiens_hsa052131.18643634
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17237742
40Colorectal cancer_Homo sapiens_hsa052101.14822237
41Bladder cancer_Homo sapiens_hsa052191.14456992
42Prion diseases_Homo sapiens_hsa050201.14433610
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14357138
44Dorso-ventral axis formation_Homo sapiens_hsa043201.12670249
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11683643
46Hematopoietic cell lineage_Homo sapiens_hsa046401.09278046
47Renal cell carcinoma_Homo sapiens_hsa052111.08971666
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08934392
49Insulin resistance_Homo sapiens_hsa049311.08538127
50Glioma_Homo sapiens_hsa052141.08204759
51HTLV-I infection_Homo sapiens_hsa051661.05632431
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05583062
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.04551861
54MicroRNAs in cancer_Homo sapiens_hsa052061.02882533
55Long-term potentiation_Homo sapiens_hsa047201.02396739
56GnRH signaling pathway_Homo sapiens_hsa049121.02086995
57TNF signaling pathway_Homo sapiens_hsa046681.01715820
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01474904
59Leukocyte transendothelial migration_Homo sapiens_hsa046701.01145404
60Nitrogen metabolism_Homo sapiens_hsa009100.99798413
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99189105
62mRNA surveillance pathway_Homo sapiens_hsa030150.97278300
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95276375
64Platelet activation_Homo sapiens_hsa046110.94497532
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94256759
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94060466
67Type II diabetes mellitus_Homo sapiens_hsa049300.94014896
68Shigellosis_Homo sapiens_hsa051310.93123859
69Proteoglycans in cancer_Homo sapiens_hsa052050.92022280
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89437009
71Prostate cancer_Homo sapiens_hsa052150.88715746
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87497107
73Tuberculosis_Homo sapiens_hsa051520.86965269
74FoxO signaling pathway_Homo sapiens_hsa040680.85544830
75Hepatitis C_Homo sapiens_hsa051600.83016655
76Systemic lupus erythematosus_Homo sapiens_hsa053220.81829019
77Viral myocarditis_Homo sapiens_hsa054160.80984448
78Estrogen signaling pathway_Homo sapiens_hsa049150.79404441
79Thyroid cancer_Homo sapiens_hsa052160.79330076
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.78924958
81African trypanosomiasis_Homo sapiens_hsa051430.78869725
82Salmonella infection_Homo sapiens_hsa051320.78681054
83Endocytosis_Homo sapiens_hsa041440.77716986
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.77682133
85Epstein-Barr virus infection_Homo sapiens_hsa051690.76520907
86Lysosome_Homo sapiens_hsa041420.76447692
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75691223
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.74641985
89Sulfur relay system_Homo sapiens_hsa041220.73590202
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.73285917
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72993652
92Type I diabetes mellitus_Homo sapiens_hsa049400.72822772
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72573360
94* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71205765
95Amoebiasis_Homo sapiens_hsa051460.70555118
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69398487
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68928459
98Choline metabolism in cancer_Homo sapiens_hsa052310.68288557
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66617270
100Adherens junction_Homo sapiens_hsa045200.66431528
101Insulin signaling pathway_Homo sapiens_hsa049100.66184772
102p53 signaling pathway_Homo sapiens_hsa041150.66168628
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64315379
104Staphylococcus aureus infection_Homo sapiens_hsa051500.64189173
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62718477
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62401965
107RNA transport_Homo sapiens_hsa030130.62287158
108MAPK signaling pathway_Homo sapiens_hsa040100.62018997
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.61649365
110Pertussis_Homo sapiens_hsa051330.60975263
111AMPK signaling pathway_Homo sapiens_hsa041520.60895706
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60701594
113HIF-1 signaling pathway_Homo sapiens_hsa040660.60497578
114ErbB signaling pathway_Homo sapiens_hsa040120.59725680
115Legionellosis_Homo sapiens_hsa051340.58225873
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57067634
117Spliceosome_Homo sapiens_hsa030400.57066161
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56835160
119Allograft rejection_Homo sapiens_hsa053300.55031297
120Phagosome_Homo sapiens_hsa041450.54564184
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54401098
122Inositol phosphate metabolism_Homo sapiens_hsa005620.53826476
123Synaptic vesicle cycle_Homo sapiens_hsa047210.53694926
124Pathways in cancer_Homo sapiens_hsa052000.53006178
125Cell cycle_Homo sapiens_hsa041100.51709163
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51395535

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