OTUD6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitotic sister chromatid separation (GO:1901970)8.35814164
2positive regulation of mitotic metaphase/anaphase transition (GO:0045842)8.35814164
3positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)8.35814164
4prenylation (GO:0097354)8.20932281
5protein prenylation (GO:0018342)8.20932281
6regulation of sister chromatid cohesion (GO:0007063)6.84939467
7purine nucleobase biosynthetic process (GO:0009113)6.32199956
8nucleobase biosynthetic process (GO:0046112)5.91382964
9double-strand break repair via nonhomologous end joining (GO:0006303)5.67996080
10non-recombinational repair (GO:0000726)5.67996080
11negative regulation of Ras GTPase activity (GO:0034261)5.61771951
12mitotic metaphase plate congression (GO:0007080)5.57915089
13ribosome assembly (GO:0042255)5.29053956
14negative regulation of T cell receptor signaling pathway (GO:0050860)5.02616003
15eosinophil chemotaxis (GO:0048245)4.81033586
16fucose catabolic process (GO:0019317)4.71610947
17L-fucose metabolic process (GO:0042354)4.71610947
18L-fucose catabolic process (GO:0042355)4.71610947
19peptidyl-lysine dimethylation (GO:0018027)4.59971650
20ribosomal small subunit assembly (GO:0000028)4.43448990
21regulation of spindle organization (GO:0090224)4.37662087
22ribosome biogenesis (GO:0042254)4.34887779
23eosinophil migration (GO:0072677)4.33100438
24regulation of translational termination (GO:0006449)4.30812063
25branch elongation of an epithelium (GO:0060602)4.30472890
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.21630783
27vesicle fusion (GO:0006906)4.17901751
28IMP biosynthetic process (GO:0006188)4.16476301
29metaphase plate congression (GO:0051310)4.13260301
30protein localization to kinetochore (GO:0034501)4.12086193
31DNA replication checkpoint (GO:0000076)4.10531153
32folic acid metabolic process (GO:0046655)4.07686551
33telomere maintenance via recombination (GO:0000722)4.04683383
34coenzyme A biosynthetic process (GO:0015937)4.03344499
35acrosome assembly (GO:0001675)4.02619226
36formation of translation preinitiation complex (GO:0001731)4.01551869
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.95420240
38regulation of mitotic sister chromatid separation (GO:0010965)3.90836431
39regulation of mitotic sister chromatid segregation (GO:0033047)3.90836431
40regulation of sister chromatid segregation (GO:0033045)3.90836431
41regulation of mitotic metaphase/anaphase transition (GO:0030071)3.90296049
42regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.90296049
43IMP metabolic process (GO:0046040)3.86664451
44mitotic recombination (GO:0006312)3.85625372
45mitochondrial RNA metabolic process (GO:0000959)3.84515203
46negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.81723804
47termination of RNA polymerase III transcription (GO:0006386)3.78947612
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.78947612
49negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.78373091
50localization within membrane (GO:0051668)3.75161410
51rRNA modification (GO:0000154)3.74866546
52mitotic nuclear envelope disassembly (GO:0007077)3.68069969
53organ growth (GO:0035265)3.67386287
54DNA replication initiation (GO:0006270)3.64091497
557-methylguanosine mRNA capping (GO:0006370)3.62843488
56negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.62253643
57nuclear pore organization (GO:0006999)3.61628151
58cullin deneddylation (GO:0010388)3.60052932
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.56817423
60regulation of mitotic spindle organization (GO:0060236)3.53887756
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.53034573
62proteasome assembly (GO:0043248)3.52931384
63regulation of mononuclear cell migration (GO:0071675)3.50824997
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50421665
65protein deneddylation (GO:0000338)3.49756572
667-methylguanosine RNA capping (GO:0009452)3.49543290
67RNA capping (GO:0036260)3.49543290
68positive regulation of chromosome segregation (GO:0051984)3.48420007
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.47911509
70histone-serine phosphorylation (GO:0035404)3.47743309
71nuclear envelope disassembly (GO:0051081)3.45455573
72membrane disassembly (GO:0030397)3.45455573
73L-methionine salvage (GO:0071267)3.35561601
74L-methionine biosynthetic process (GO:0071265)3.35561601
75amino acid salvage (GO:0043102)3.35561601
76spliceosomal snRNP assembly (GO:0000387)3.34783370
77CENP-A containing nucleosome assembly (GO:0034080)3.34466832
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34278584
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33631164
80RNA methylation (GO:0001510)3.32832846
81mitotic sister chromatid cohesion (GO:0007064)3.32713317
82transcription elongation from RNA polymerase I promoter (GO:0006362)3.32555865
83establishment of chromosome localization (GO:0051303)3.32546723
84DNA double-strand break processing (GO:0000729)3.32440403
85termination of RNA polymerase I transcription (GO:0006363)3.31274754
86folic acid-containing compound biosynthetic process (GO:0009396)3.30674239
87positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29695807
88regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.28838634
89synapsis (GO:0007129)3.24655647
90transcription from RNA polymerase I promoter (GO:0006360)3.24639361
91tricarboxylic acid cycle (GO:0006099)3.24058699
92chromatin remodeling at centromere (GO:0031055)3.23122507
93maturation of 5.8S rRNA (GO:0000460)3.23015645
94establishment of integrated proviral latency (GO:0075713)3.22359487
95pseudouridine synthesis (GO:0001522)3.21767878
96chaperone-mediated protein transport (GO:0072321)3.21350855
97spindle checkpoint (GO:0031577)3.21148421
98negative regulation of circadian rhythm (GO:0042754)3.20574812
99protein import into peroxisome matrix (GO:0016558)3.18650746
100regulation of centriole replication (GO:0046599)3.18473591
101rRNA processing (GO:0006364)3.15204693
102G1/S transition of mitotic cell cycle (GO:0000082)3.12486428
103cell cycle G1/S phase transition (GO:0044843)3.12486428
104protein localization to chromosome, centromeric region (GO:0071459)3.12291542
105positive regulation of ligase activity (GO:0051351)3.11241468
106mitotic sister chromatid segregation (GO:0000070)3.10219762
107response to X-ray (GO:0010165)3.10188901
108telomere maintenance (GO:0000723)3.09986512
109ribonucleoprotein complex biogenesis (GO:0022613)3.09131657
110transcription initiation from RNA polymerase I promoter (GO:0006361)3.08469843
111telomere organization (GO:0032200)3.07868828
112NADH metabolic process (GO:0006734)3.07844456
113glycine metabolic process (GO:0006544)3.06435089
114axis elongation (GO:0003401)3.06397837
115regulation of acyl-CoA biosynthetic process (GO:0050812)3.05539282
116regulation of coenzyme metabolic process (GO:0051196)3.05224939
117regulation of cofactor metabolic process (GO:0051193)3.05224939
118monoubiquitinated protein deubiquitination (GO:0035520)3.05141784
119regulation of stem cell maintenance (GO:2000036)3.04696705
120negative regulation of ligase activity (GO:0051352)3.04419617
121negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04419617
122rRNA metabolic process (GO:0016072)3.03941540
123rRNA methylation (GO:0031167)3.02747184
124regulation of RNA export from nucleus (GO:0046831)3.02311244
125folic acid transport (GO:0015884)3.02283793
126regulation of ubiquitin-protein transferase activity (GO:0051438)3.01558577
127establishment of protein localization to mitochondrion (GO:0072655)3.01195701
128protein sumoylation (GO:0016925)3.00521065
129regulation of chromosome segregation (GO:0051983)3.00483699
130maturation of SSU-rRNA (GO:0030490)3.00407247
131mitotic spindle checkpoint (GO:0071174)3.00394340
132DNA strand elongation involved in DNA replication (GO:0006271)2.98883910
133histone H3-K9 methylation (GO:0051567)2.98353972
134protein targeting to mitochondrion (GO:0006626)2.98344737
135nuclear pore complex assembly (GO:0051292)2.96704053
136histone exchange (GO:0043486)2.95940873
137DNA-templated transcription, elongation (GO:0006354)2.95588646
138somatic hypermutation of immunoglobulin genes (GO:0016446)2.95093556
139somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95093556
140transcription-coupled nucleotide-excision repair (GO:0006283)2.94551058
141transcription elongation from RNA polymerase II promoter (GO:0006368)2.94353308
142DNA replication-independent nucleosome organization (GO:0034724)2.94239102
143DNA replication-independent nucleosome assembly (GO:0006336)2.94239102
144protein localization to mitochondrion (GO:0070585)2.94100319
145DNA integration (GO:0015074)2.93039189
146tRNA aminoacylation for protein translation (GO:0006418)2.92495759
147pteridine-containing compound biosynthetic process (GO:0042559)2.89966447
148negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89075666
149negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89075666
150negative regulation of mitotic sister chromatid separation (GO:2000816)2.89075666
151autophagic vacuole fusion (GO:0000046)2.88722326
152amino acid activation (GO:0043038)2.88432358
153tRNA aminoacylation (GO:0043039)2.88432358
154L-serine metabolic process (GO:0006563)2.87862399
155oxidative demethylation (GO:0070989)2.87612987
156regulation of ligase activity (GO:0051340)2.87217026
157membrane budding (GO:0006900)2.86733670
158nuclear envelope organization (GO:0006998)2.86680519
159negative regulation of chromosome segregation (GO:0051985)2.86028027
160telomere maintenance via telomere lengthening (GO:0010833)2.85731127
161methionine biosynthetic process (GO:0009086)2.84796455
162methionine metabolic process (GO:0006555)2.84683326
163establishment of mitotic spindle orientation (GO:0000132)2.83014389
164protein complex localization (GO:0031503)2.82897233
165tRNA modification (GO:0006400)2.82800245
166negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82492591
167negative regulation of sister chromatid segregation (GO:0033046)2.82492591
168negative regulation of DNA-dependent DNA replication (GO:2000104)2.81366812
169regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.80634661
170establishment of mitotic spindle localization (GO:0040001)2.80146101
171intracellular protein transmembrane import (GO:0044743)2.80017402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.72311438
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.36298734
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.34463200
4GATA1_22025678_ChIP-Seq_K562_Human4.20062709
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.87165313
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.74162787
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.57328048
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.48930796
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47679649
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.47508866
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42515986
12VDR_22108803_ChIP-Seq_LS180_Human3.42297875
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.41883455
14* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17144670
15* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00838582
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99461138
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94640480
18AR_21909140_ChIP-Seq_LNCAP_Human2.78210033
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.78030380
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65347691
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.60182427
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58227280
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46730352
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45736683
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35020269
26* VDR_23849224_ChIP-Seq_CD4+_Human2.33316650
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.23618189
28RBPJ_22232070_ChIP-Seq_NCS_Mouse2.22170194
29MYCN_18555785_ChIP-Seq_MESCs_Mouse2.21243877
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20257672
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15526569
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14107306
33* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11487777
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11192035
35XRN2_22483619_ChIP-Seq_HELA_Human2.10204652
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.07930767
37GABP_19822575_ChIP-Seq_HepG2_Human2.07684120
38FUS_26573619_Chip-Seq_HEK293_Human2.07649439
39DCP1A_22483619_ChIP-Seq_HELA_Human2.04020854
40ELK1_19687146_ChIP-ChIP_HELA_Human1.89344608
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88908056
42FOXP3_21729870_ChIP-Seq_TREG_Human1.88718282
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.77566032
44ZNF274_21170338_ChIP-Seq_K562_Hela1.77282387
45EWS_26573619_Chip-Seq_HEK293_Human1.76943958
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75613948
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73243189
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71776846
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69843278
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68124175
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65392401
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61250413
53* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59549736
54* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58419847
55TTF2_22483619_ChIP-Seq_HELA_Human1.57912770
56TAF15_26573619_Chip-Seq_HEK293_Human1.56150396
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53773543
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.53690393
59* SRF_21415370_ChIP-Seq_HL-1_Mouse1.53652934
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53498569
61KDM5A_27292631_Chip-Seq_BREAST_Human1.52710818
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52095377
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.49290647
64ZNF263_19887448_ChIP-Seq_K562_Human1.47538379
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45215633
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44106649
67GBX2_23144817_ChIP-Seq_PC3_Human1.37207229
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32505447
69IGF1R_20145208_ChIP-Seq_DFB_Human1.31133544
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29676366
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28275420
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28252247
73P300_19829295_ChIP-Seq_ESCs_Human1.28034146
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25276314
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23947384
76* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23777212
77* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22830878
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22464101
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22427992
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18268275
81AR_21572438_ChIP-Seq_LNCaP_Human1.17844853
82* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14955997
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13930140
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13699522
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12396386
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.12353883
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12273100
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11732407
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11283340
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.11218692
91IRF1_19129219_ChIP-ChIP_H3396_Human1.10911789
92TFEB_21752829_ChIP-Seq_HELA_Human1.10233271
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07684124
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04313536
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03479958
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02001870
97* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99533642
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99495006
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99368973
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99218878
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.98322675
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97256690
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96840839
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95049026
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.94810467
106* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94628169
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94466942
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92702062
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92702062
110CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92293125
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91491662
112PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91483539
113EZH2_27294783_Chip-Seq_NPCs_Mouse0.89270032
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89060558
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88780338
116CIITA_25753668_ChIP-Seq_RAJI_Human0.88391709
117PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88345150
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88212820
119EGR1_19374776_ChIP-ChIP_THP-1_Human0.87827223
120MYC_18940864_ChIP-ChIP_HL60_Human0.87654027
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86048460
122BCAT_22108803_ChIP-Seq_LS180_Human0.85471958
123ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84331733
124CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82545305
125TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.82083933
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.81807311
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81311314
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80947454
129ELF1_17652178_ChIP-ChIP_JURKAT_Human0.80659656
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80422156
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79775228
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79744644
133KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79249574
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79243690
135NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79134714
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78920585
137CBP_20019798_ChIP-Seq_JUKART_Human0.78920585
138TP53_22573176_ChIP-Seq_HFKS_Human0.78898677
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76014680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.66695494
2MP0003693_abnormal_embryo_hatching5.41270090
3MP0004957_abnormal_blastocyst_morpholog4.11592663
4MP0003111_abnormal_nucleus_morphology3.79757796
5MP0010094_abnormal_chromosome_stability3.54883011
6MP0003303_peritoneal_inflammation3.45269741
7MP0003077_abnormal_cell_cycle3.13674577
8MP0003123_paternal_imprinting2.87422086
9MP0001730_embryonic_growth_arrest2.58903762
10MP0008057_abnormal_DNA_replication2.56819751
11MP0004084_abnormal_cardiac_muscle2.55382839
12MP0003806_abnormal_nucleotide_metabolis2.52704061
13MP0008932_abnormal_embryonic_tissue2.50005545
14MP0003718_maternal_effect2.45298299
15MP0002751_abnormal_autonomic_nervous2.40610954
16MP0003646_muscle_fatigue2.37760866
17MP0003221_abnormal_cardiomyocyte_apopto2.34604468
18MP0000383_abnormal_hair_follicle2.26769948
19MP0000750_abnormal_muscle_regeneration2.20011442
20MP0003937_abnormal_limbs/digits/tail_de2.19429880
21MP0010678_abnormal_skin_adnexa2.04651017
22MP0006036_abnormal_mitochondrial_physio2.04275793
23MP0004215_abnormal_myocardial_fiber2.01737287
24MP0000350_abnormal_cell_proliferation1.98007228
25MP0008058_abnormal_DNA_repair1.95767008
26MP0003941_abnormal_skin_development1.94605575
27MP0010307_abnormal_tumor_latency1.90011978
28MP0008007_abnormal_cellular_replicative1.88173361
29MP0001919_abnormal_reproductive_system1.86917658
30MP0000467_abnormal_esophagus_morphology1.81923928
31MP0001529_abnormal_vocalization1.81891784
32MP0003115_abnormal_respiratory_system1.76266059
33MP0001672_abnormal_embryogenesis/_devel1.75874739
34MP0005380_embryogenesis_phenotype1.75874739
35MP0004036_abnormal_muscle_relaxation1.74921496
36MP0001697_abnormal_embryo_size1.72113252
37MP0006035_abnormal_mitochondrial_morpho1.69399247
38MP0000747_muscle_weakness1.69286863
39MP0004233_abnormal_muscle_weight1.68993929
40MP0002269_muscular_atrophy1.65281994
41MP0006082_CNS_inflammation1.62447355
42MP0003984_embryonic_growth_retardation1.61131427
43MP0003950_abnormal_plasma_membrane1.57904494
44MP0002837_dystrophic_cardiac_calcinosis1.57699100
45MP0002088_abnormal_embryonic_growth/wei1.57465923
46MP0000751_myopathy1.57445088
47MP0008260_abnormal_autophagy1.55654843
48MP0003186_abnormal_redox_activity1.54813878
49MP0001286_abnormal_eye_development1.53006877
50MP0002080_prenatal_lethality1.51059175
51MP0003786_premature_aging1.49481435
52MP0001661_extended_life_span1.48270665
53MP0005330_cardiomyopathy1.43590793
54MP0000358_abnormal_cell_content/1.38679398
55MP0009697_abnormal_copulation1.37320895
56MP0010352_gastrointestinal_tract_polyps1.37263254
57MP0003567_abnormal_fetal_cardiomyocyte1.37229145
58MP0001664_abnormal_digestion1.35305938
59MP0009840_abnormal_foam_cell1.27598842
60MP0002084_abnormal_developmental_patter1.27273148
61MP0002085_abnormal_embryonic_tissue1.23587138
62MP0000372_irregular_coat_pigmentation1.22922185
63MP0000749_muscle_degeneration1.22146076
64MP0008877_abnormal_DNA_methylation1.19865032
65MP0002019_abnormal_tumor_incidence1.19022173
66MP0004145_abnormal_muscle_electrophysio1.18955765
67MP0006072_abnormal_retinal_apoptosis1.16095160
68MP0000428_abnormal_craniofacial_morphol1.13980863
69MP0002396_abnormal_hematopoietic_system1.13609008
70MP0004087_abnormal_muscle_fiber1.13459204
71MP0001984_abnormal_olfaction1.12668969
72MP0001915_intracranial_hemorrhage1.12389316
73MP0002106_abnormal_muscle_physiology1.12327147
74MP0002160_abnormal_reproductive_system1.10849231
75MP0005266_abnormal_metabolism1.08742480
76MP0002086_abnormal_extraembryonic_tissu1.08403623
77MP0003890_abnormal_embryonic-extraembry1.07025869
78MP0009672_abnormal_birth_weight1.04771430
79MP0006138_congestive_heart_failure1.03961810
80MP0005501_abnormal_skin_physiology1.00583064
81MP0002102_abnormal_ear_morphology0.99596588
82MP0001663_abnormal_digestive_system0.99375843
83MP0005620_abnormal_muscle_contractility0.99009048
84MP0005408_hypopigmentation0.98103783
85MP0004185_abnormal_adipocyte_glucose0.94293216
86MP0004130_abnormal_muscle_cell0.92684299
87MP0008775_abnormal_heart_ventricle0.92570249
88MP0004043_abnormal_pH_regulation0.92180922
89MP0010234_abnormal_vibrissa_follicle0.89910197
90MP0000490_abnormal_crypts_of0.89160582
91MP0003705_abnormal_hypodermis_morpholog0.88605497
92MP0003656_abnormal_erythrocyte_physiolo0.88211836
93MP0005385_cardiovascular_system_phenoty0.87721907
94MP0001544_abnormal_cardiovascular_syste0.87721907
95MP0004197_abnormal_fetal_growth/weight/0.86299470
96MP0002127_abnormal_cardiovascular_syste0.84512568
97MP0005369_muscle_phenotype0.84431037
98MP0000647_abnormal_sebaceous_gland0.84227701
99MP0002332_abnormal_exercise_endurance0.83627292
100MP0003121_genomic_imprinting0.83488689
101MP0005332_abnormal_amino_acid0.83025142
102MP0002697_abnormal_eye_size0.82975380
103MP0005253_abnormal_eye_physiology0.82969523
104MP0001145_abnormal_male_reproductive0.82938983
105MP0002876_abnormal_thyroid_physiology0.81363219
106MP0000313_abnormal_cell_death0.80954856
107MP0002210_abnormal_sex_determination0.80798068
108MP0003935_abnormal_craniofacial_develop0.79854682
109MP0005187_abnormal_penis_morphology0.79465033
110MP0001177_atelectasis0.79344522
111MP0000516_abnormal_urinary_system0.79290230
112MP0005367_renal/urinary_system_phenotyp0.79290230
113MP0005384_cellular_phenotype0.79255523
114MP0003787_abnormal_imprinting0.79222475
115MP0000427_abnormal_hair_cycle0.78855774
116MP0008995_early_reproductive_senescence0.78022625
117MP0001188_hyperpigmentation0.77675835
118MP0002090_abnormal_vision0.77528494
119MP0002184_abnormal_innervation0.76636226
120MP0002972_abnormal_cardiac_muscle0.76206715
121MP0000759_abnormal_skeletal_muscle0.74818753
122MP0003119_abnormal_digestive_system0.74524930
123MP0001119_abnormal_female_reproductive0.74363833
124MP0001727_abnormal_embryo_implantation0.73940731
125MP0001542_abnormal_bone_strength0.73653924
126MP0003136_yellow_coat_color0.73236975
127MP0001293_anophthalmia0.72303157
128MP0005397_hematopoietic_system_phenotyp0.72185172
129MP0001545_abnormal_hematopoietic_system0.72185172
130MP0005381_digestive/alimentary_phenotyp0.72081774
131MP0004147_increased_porphyrin_level0.71595301
132MP0008770_decreased_survivor_rate0.71437993
133MP0005621_abnormal_cell_physiology0.71384079
134MP0000432_abnormal_head_morphology0.71016577
135MP0003137_abnormal_impulse_conducting0.70300278
136MP0005395_other_phenotype0.70193993
137MP0010386_abnormal_urinary_bladder0.69977707
138MP0001929_abnormal_gametogenesis0.69946890
139MP0005379_endocrine/exocrine_gland_phen0.69111947
140MP0002109_abnormal_limb_morphology0.68844937
141MP0003329_amyloid_beta_deposits0.68268251
142MP0000653_abnormal_sex_gland0.67968668
143MP0005391_vision/eye_phenotype0.67876760
144MP0005076_abnormal_cell_differentiation0.67875840
145MP0005389_reproductive_system_phenotype0.66585064
146MP0001764_abnormal_homeostasis0.64700043
147MP0009703_decreased_birth_body0.63499613
148MP0005451_abnormal_body_composition0.63213850
149MP0006292_abnormal_olfactory_placode0.62870606
150MP0010630_abnormal_cardiac_muscle0.62343870
151MP0002734_abnormal_mechanical_nocicepti0.61441276
152MP0003315_abnormal_perineum_morphology0.60623785

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)6.47739436
2Duplicated collecting system (HP:0000081)5.58724927
3Abnormality of the renal collecting system (HP:0004742)5.11703204
4Long foot (HP:0001833)5.05745916
5Birth length less than 3rd percentile (HP:0003561)4.95070718
6Cerebral hypomyelination (HP:0006808)4.90481930
7Acute lymphatic leukemia (HP:0006721)4.36597256
8Hyperglycinemia (HP:0002154)4.22334144
9Large for gestational age (HP:0001520)3.88246019
10Hypoplastic pelvis (HP:0008839)3.82852914
11Abnormality of glycolysis (HP:0004366)3.76145541
12Increased serum pyruvate (HP:0003542)3.76145541
13Abnormality of the labia minora (HP:0012880)3.69005160
14Autoamputation (HP:0001218)3.59904541
15Abnormal auditory evoked potentials (HP:0006958)3.54889355
16Abnormality of serine family amino acid metabolism (HP:0010894)3.37833019
17Abnormality of glycine metabolism (HP:0010895)3.37833019
18Muscle fiber splitting (HP:0003555)3.36361238
19CNS hypomyelination (HP:0003429)3.34958331
20Breast hypoplasia (HP:0003187)3.33827263
21Brushfield spots (HP:0001088)3.33463835
22Hyperglycinuria (HP:0003108)3.29656066
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.26380992
24Abnormality of alanine metabolism (HP:0010916)3.26380992
25Hyperalaninemia (HP:0003348)3.26380992
26Shoulder girdle muscle weakness (HP:0003547)3.24340002
27Abnormality of fatty-acid metabolism (HP:0004359)3.13625913
28Dry hair (HP:0011359)3.10982530
29Carpal bone hypoplasia (HP:0001498)3.10862037
30Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08036697
31Progressive muscle weakness (HP:0003323)3.06654193
32Rough bone trabeculation (HP:0100670)3.05964839
33Abnormality of serum amino acid levels (HP:0003112)3.04531690
34Adactyly (HP:0009776)3.02725596
35Pelvic girdle muscle weakness (HP:0003749)2.95267496
36Multiple enchondromatosis (HP:0005701)2.92642532
37Chromsome breakage (HP:0040012)2.91028953
38Clubbing of toes (HP:0100760)2.86198260
39Ependymoma (HP:0002888)2.85392966
40Gout (HP:0001997)2.80159865
41Abnormality of chromosome stability (HP:0003220)2.79511487
42Abnormality of the hip-girdle musculature (HP:0001445)2.72800990
43Abnormality of the musculature of the pelvis (HP:0001469)2.72800990
44Oral leukoplakia (HP:0002745)2.66547656
45CNS demyelination (HP:0007305)2.65274588
46Nemaline bodies (HP:0003798)2.61039660
47Postnatal microcephaly (HP:0005484)2.58809759
48Volvulus (HP:0002580)2.58443389
49Colon cancer (HP:0003003)2.58233820
50Broad-based gait (HP:0002136)2.57485522
51Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.54526502
52B lymphocytopenia (HP:0010976)2.54172712
53Areflexia of lower limbs (HP:0002522)2.52670700
54Decreased lacrimation (HP:0000633)2.51678002
55Impulsivity (HP:0100710)2.51445575
56Increased CSF lactate (HP:0002490)2.49263855
57Muscle fiber inclusion bodies (HP:0100299)2.48619349
58Acute necrotizing encephalopathy (HP:0006965)2.47233832
59Exercise-induced muscle cramps (HP:0003710)2.46256624
60Menstrual irregularities (HP:0000858)2.43288079
61Atrioventricular block (HP:0001678)2.43093864
62Rhabdomyosarcoma (HP:0002859)2.42756109
63Meckel diverticulum (HP:0002245)2.42730381
64Difficulty climbing stairs (HP:0003551)2.41855524
65Glioma (HP:0009733)2.40885906
66Abnormal mitochondria in muscle tissue (HP:0008316)2.39318127
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.34966376
68Abnormality of the anterior horn cell (HP:0006802)2.34242526
69Degeneration of anterior horn cells (HP:0002398)2.34242526
70Increased serum lactate (HP:0002151)2.34122378
71Unsteady gait (HP:0002317)2.33143129
72Megaloblastic anemia (HP:0001889)2.31714304
73Abnormality of the preputium (HP:0100587)2.31574360
74Tetraplegia (HP:0002445)2.30690299
75Nephroblastoma (Wilms tumor) (HP:0002667)2.30240521
76Abnormal connection of the cardiac segments (HP:0011545)2.30034622
77Abnormal ventriculo-arterial connection (HP:0011563)2.30034622
78Transposition of the great arteries (HP:0001669)2.30034622
79Ureteral duplication (HP:0000073)2.29609975
80Abnormal lung lobation (HP:0002101)2.28514881
81Abnormality of B cell number (HP:0010975)2.25240221
82Abnormality of the ileum (HP:0001549)2.24862904
83Chorioretinal coloboma (HP:0000567)2.24698614
84Small intestinal stenosis (HP:0012848)2.23861413
85Duodenal stenosis (HP:0100867)2.23861413
86Abnormal trabecular bone morphology (HP:0100671)2.23619182
87Steatorrhea (HP:0002570)2.23467010
88Astrocytoma (HP:0009592)2.22336590
89Abnormality of the astrocytes (HP:0100707)2.22336590
90Secondary amenorrhea (HP:0000869)2.22197570
91Acute encephalopathy (HP:0006846)2.21408165
92Facial hemangioma (HP:0000329)2.21246723
93Palmar hyperkeratosis (HP:0010765)2.21011471
94Embryonal renal neoplasm (HP:0011794)2.20424810
95Medulloblastoma (HP:0002885)2.20370079
96Premature ovarian failure (HP:0008209)2.16808602
97Cerebral edema (HP:0002181)2.16008224
98Increased hepatocellular lipid droplets (HP:0006565)2.14767209
99Severe muscular hypotonia (HP:0006829)2.14350830
100Delusions (HP:0000746)2.13119599
101Patellar aplasia (HP:0006443)2.12282561
102Palmoplantar hyperkeratosis (HP:0000972)2.10713608
103Large hands (HP:0001176)2.10553201
104Aplasia/Hypoplasia of the patella (HP:0006498)2.10447016
105Mitochondrial inheritance (HP:0001427)2.08901145
106Lethargy (HP:0001254)2.07221298
107Glossoptosis (HP:0000162)2.06862878
108Reduced subcutaneous adipose tissue (HP:0003758)2.06414835
109Decreased muscle mass (HP:0003199)2.06017991
110Hypoplastic nipples (HP:0002557)2.04954979
111Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04896187
112Progressive macrocephaly (HP:0004481)2.04680797
113Pheochromocytoma (HP:0002666)2.04033434
114Abnormality of methionine metabolism (HP:0010901)2.03619742
115Lipid accumulation in hepatocytes (HP:0006561)2.03507625
116Neoplasm of the peripheral nervous system (HP:0100007)2.02925460
117Abnormality of the umbilical cord (HP:0010881)2.02867304
118Rhabdomyolysis (HP:0003201)2.01711571
119Bundle branch block (HP:0011710)2.01221124
120Hepatic necrosis (HP:0002605)2.00808598
121Female pseudohermaphroditism (HP:0010458)2.00518009
122Wide intermamillary distance (HP:0006610)2.00450935
123Increased number of teeth (HP:0011069)2.00070580
124Abnormality of the duodenum (HP:0002246)2.00038654
125Lactic acidosis (HP:0003128)1.97960355
126Methylmalonic acidemia (HP:0002912)1.96268098
127Abnormality of the lower motor neuron (HP:0002366)1.95297993
128Emotional lability (HP:0000712)1.94794779
129Hepatocellular necrosis (HP:0001404)1.94680120
130Absent radius (HP:0003974)1.94573192
131Ureteral stenosis (HP:0000071)1.93591353
132Neuroendocrine neoplasm (HP:0100634)1.92876220
133Rimmed vacuoles (HP:0003805)1.91785041
134Horseshoe kidney (HP:0000085)1.91366627
135Palpitations (HP:0001962)1.89390331
136Death in infancy (HP:0001522)1.85455643
137Neoplasm of the adrenal cortex (HP:0100641)1.84292368
138Focal motor seizures (HP:0011153)1.84200822
139Abnormality of vision evoked potentials (HP:0000649)1.81923850
140Epiphyseal stippling (HP:0010655)1.81501183
141Myotonia (HP:0002486)1.81260222
142Global brain atrophy (HP:0002283)1.80774954
143Abnormalities of placenta or umbilical cord (HP:0001194)1.79116806
144External ear malformation (HP:0008572)1.78807707
145Respiratory failure (HP:0002878)1.78770085
146Polymicrogyria (HP:0002126)1.78569106
147Anhidrosis (HP:0000970)1.78342078
148Atrophy/Degeneration involving motor neurons (HP:0007373)1.77841300
149Agnosia (HP:0010524)1.77678154
150Microretrognathia (HP:0000308)1.77589146
151Respiratory difficulties (HP:0002880)1.76788879
152Neck muscle weakness (HP:0000467)1.76238160
153Freckling (HP:0001480)1.75844853
154Neoplasm of the adrenal gland (HP:0100631)1.75388261
155Neoplasm of the colon (HP:0100273)1.74631200
156Hyperglycemia (HP:0003074)1.74414729
157Breast aplasia (HP:0100783)1.73593100
158Ureteral obstruction (HP:0006000)1.71546916
159Absent forearm bone (HP:0003953)1.71088632
160Aplasia involving forearm bones (HP:0009822)1.71088632
161Exercise-induced myalgia (HP:0003738)1.70882073
162Type I transferrin isoform profile (HP:0003642)1.70815234
163Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70739882
164Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70739882
165Irregular epiphyses (HP:0010582)1.70413281
166Thyroiditis (HP:0100646)1.69975191
167Exercise intolerance (HP:0003546)1.69854368
168Pulmonary artery stenosis (HP:0004415)1.69484585
169Intestinal atresia (HP:0011100)1.68831411
1703-Methylglutaconic aciduria (HP:0003535)1.68261167
171Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68213091
172Personality changes (HP:0000751)1.68037621
173Impaired pain sensation (HP:0007328)1.68013227
174Abnormality of pain sensation (HP:0010832)1.68013227
175Hypoproteinemia (HP:0003075)1.67614422
176Cortical dysplasia (HP:0002539)1.66445306
177Flat face (HP:0012368)1.65438981
178Neoplasm of the oral cavity (HP:0100649)1.64546689
179Sloping forehead (HP:0000340)1.63125543
180Prominent metopic ridge (HP:0005487)1.60755387
181Hypoplastic iliac wings (HP:0002866)1.60077366
182Scrotal hypoplasia (HP:0000046)1.59693969
183Decreased testicular size (HP:0008734)1.58392187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.41906828
2WEE14.24084284
3TAOK13.56683469
4NEK13.50429189
5TAOK23.48728002
6EIF2AK13.16996895
7TSSK62.76316562
8BRSK22.72375229
9LATS22.69319843
10PDK32.64986243
11PDK42.64986243
12MAP3K32.38182264
13CDC72.32548983
14PLK32.25866669
15MAP2K32.16935257
16EIF2AK32.07863651
17PDK22.07291829
18MAP3K111.89202658
19SRPK11.89045406
20CCNB11.85903782
21NEK21.82042450
22TTK1.75749974
23PLK41.75530707
24TRIM281.74966791
25AKT31.74908259
26ACVR1B1.73555639
27PLK11.70045206
28BRSK11.62489787
29ARAF1.59045494
30STK161.44872567
31NME11.43963586
32LIMK11.41839047
33STK38L1.41301379
34NME21.38262711
35BRAF1.36693588
36PLK21.34484557
37LATS11.33293779
38WNK31.25742094
39KSR21.24709177
40DYRK1A1.23797038
41BCKDK1.19798036
42MST41.17875660
43JAK31.17266528
44PNCK1.17023756
45TNIK1.14752308
46AURKB1.14534043
47FRK1.11688288
48EPHA21.09584056
49ERBB31.08789284
50CAMKK21.08476921
51DYRK31.08115552
52MAP3K81.07944668
53STK31.02270599
54RAF11.01297655
55MKNK11.00168653
56CHEK20.98422655
57MAP4K20.97742299
58NUAK10.97458122
59AURKA0.95394336
60MKNK20.92290316
61MAP3K90.89877452
62KSR10.86944711
63BMPR1B0.80783785
64TAF10.79991838
65ZAK0.79717365
66CHEK10.79709639
67RPS6KA40.78895474
68TTN0.75632473
69ALK0.74223526
70SCYL20.72277538
71LMTK20.70709653
72VRK10.69977798
73TESK20.69884432
74NTRK30.69358119
75ATR0.68404744
76MAP3K50.67155102
77CDK80.65940177
78VRK20.65453923
79PBK0.65318943
80ABL20.65263473
81OBSCN0.64492729
82PHKG10.62089309
83PHKG20.62089309
84EIF2AK20.60967704
85PAK10.60862003
86PAK60.59365258
87STK100.57716366
88CDK70.56003249
89CSNK2A20.54698509
90CSNK1E0.54237809
91SIK30.54041736
92CASK0.53281171
93PINK10.52140167
94CDK20.50159153
95CDK140.49864937
96CSNK1G10.49383321
97MAP3K40.49259977
98ERBB40.47700742
99MET0.47376863
100PASK0.46426789
101TESK10.43967928
102GRK50.43043902
103ATM0.42226004
104NEK90.41754234
105PIM20.41619480
106CSNK2A10.41495746
107MINK10.41121966
108STK240.39960330
109CSNK1G30.39803924
110MAP3K20.38924098
111CDK10.38902500
112RPS6KB20.38720115
113PIK3CA0.38350329
114PRKD30.36411762
115MAP2K10.36169588
116CDK180.35751451
117CSNK1G20.35646968
118BCR0.34686567
119MELK0.34627136
120CDK40.34529823
121CDK150.34276117
122PRKCI0.31959726
123CSNK1A10.31090429
124PRKCG0.30977715
125MAPK130.29685461
126CSNK1A1L0.29325627
127MAP2K70.28101223
128CDK11A0.27858206
129FGFR20.27451168
130CDK30.27311105
131TGFBR10.27155462
132EPHA40.26336942
133FGFR10.21887299
134OXSR10.21673859
135STK390.20392350
136MST1R0.19556781
137BRD40.19529303
138PRKCE0.18994834
139PRKCQ0.15997914
140IGF1R0.14568073
141MAP3K10.14330871
142STK40.13411149
143YES10.13338382
144NLK0.10097288
145ABL10.09624721

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.31774201
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.15609840
3RNA polymerase_Homo sapiens_hsa030204.06341101
4Proteasome_Homo sapiens_hsa030503.63909701
5RNA transport_Homo sapiens_hsa030133.24787002
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.98058118
7DNA replication_Homo sapiens_hsa030302.67633869
8Cell cycle_Homo sapiens_hsa041102.35387942
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.28522762
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27950158
11Pyrimidine metabolism_Homo sapiens_hsa002402.21475415
12Mismatch repair_Homo sapiens_hsa034302.16244611
13Spliceosome_Homo sapiens_hsa030402.10917264
14Biosynthesis of amino acids_Homo sapiens_hsa012302.04658123
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97745443
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96797257
17Carbon metabolism_Homo sapiens_hsa012001.94244498
18Basal transcription factors_Homo sapiens_hsa030221.91890246
19Nucleotide excision repair_Homo sapiens_hsa034201.87017780
20Pentose phosphate pathway_Homo sapiens_hsa000301.82362451
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.75136541
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74286106
23One carbon pool by folate_Homo sapiens_hsa006701.72645324
24Oocyte meiosis_Homo sapiens_hsa041141.61493190
25Purine metabolism_Homo sapiens_hsa002301.49982051
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45505100
27Homologous recombination_Homo sapiens_hsa034401.41618883
28Lysine degradation_Homo sapiens_hsa003101.35532589
29Ribosome_Homo sapiens_hsa030101.34992195
30RNA degradation_Homo sapiens_hsa030181.34178162
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32555786
32Oxidative phosphorylation_Homo sapiens_hsa001901.31116177
33Folate biosynthesis_Homo sapiens_hsa007901.29313487
34Taste transduction_Homo sapiens_hsa047421.27027203
35Regulation of autophagy_Homo sapiens_hsa041401.26840824
36Parkinsons disease_Homo sapiens_hsa050121.20388577
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19037195
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17096721
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16594675
40Propanoate metabolism_Homo sapiens_hsa006401.15921502
41Huntingtons disease_Homo sapiens_hsa050161.13571796
42mRNA surveillance pathway_Homo sapiens_hsa030151.13202943
43Pyruvate metabolism_Homo sapiens_hsa006201.11735819
44Butanoate metabolism_Homo sapiens_hsa006501.05075625
45Base excision repair_Homo sapiens_hsa034101.01045220
46Sulfur relay system_Homo sapiens_hsa041221.00322731
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98784470
48p53 signaling pathway_Homo sapiens_hsa041150.96134217
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95330679
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93790838
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.90910479
52Fructose and mannose metabolism_Homo sapiens_hsa000510.90835887
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90296530
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90260196
55Fanconi anemia pathway_Homo sapiens_hsa034600.88182333
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87341070
57Glutathione metabolism_Homo sapiens_hsa004800.75765773
58Epstein-Barr virus infection_Homo sapiens_hsa051690.73543193
59Nitrogen metabolism_Homo sapiens_hsa009100.72886178
60Steroid biosynthesis_Homo sapiens_hsa001000.71879429
61Non-homologous end-joining_Homo sapiens_hsa034500.71861570
62Selenocompound metabolism_Homo sapiens_hsa004500.70578347
63Arginine and proline metabolism_Homo sapiens_hsa003300.70240331
64Cardiac muscle contraction_Homo sapiens_hsa042600.68697132
65Thyroid cancer_Homo sapiens_hsa052160.64363312
66Tryptophan metabolism_Homo sapiens_hsa003800.63365399
67Alzheimers disease_Homo sapiens_hsa050100.60357961
68Metabolic pathways_Homo sapiens_hsa011000.57913473
69Caffeine metabolism_Homo sapiens_hsa002320.52844163
70Collecting duct acid secretion_Homo sapiens_hsa049660.52373537
71Synaptic vesicle cycle_Homo sapiens_hsa047210.51714785
72Nicotine addiction_Homo sapiens_hsa050330.50956693
73Protein export_Homo sapiens_hsa030600.49170076
74Arginine biosynthesis_Homo sapiens_hsa002200.47276854
75Fatty acid metabolism_Homo sapiens_hsa012120.44848191
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44732465
77mTOR signaling pathway_Homo sapiens_hsa041500.42145257
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40901700
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.40603475
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.40481181
81Fatty acid degradation_Homo sapiens_hsa000710.38874439
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38055448
83Fatty acid elongation_Homo sapiens_hsa000620.37813877
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.32855189
85N-Glycan biosynthesis_Homo sapiens_hsa005100.30678827
86beta-Alanine metabolism_Homo sapiens_hsa004100.28293800
87MicroRNAs in cancer_Homo sapiens_hsa052060.28264689
88TGF-beta signaling pathway_Homo sapiens_hsa043500.27227616
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.26318800
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26258617
91Viral carcinogenesis_Homo sapiens_hsa052030.25887515
92Olfactory transduction_Homo sapiens_hsa047400.24045609
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22292454
94Glycerolipid metabolism_Homo sapiens_hsa005610.22256397
95Tight junction_Homo sapiens_hsa045300.22235184
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21304774
97Phototransduction_Homo sapiens_hsa047440.21155166
98Sulfur metabolism_Homo sapiens_hsa009200.21086303
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19025749
100Hippo signaling pathway_Homo sapiens_hsa043900.17900357
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15751193
102Glucagon signaling pathway_Homo sapiens_hsa049220.15705517
103Vitamin digestion and absorption_Homo sapiens_hsa049770.15120969
104Systemic lupus erythematosus_Homo sapiens_hsa053220.15083393
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14465439
106Vibrio cholerae infection_Homo sapiens_hsa051100.13994037
107HIF-1 signaling pathway_Homo sapiens_hsa040660.13687487
108Circadian rhythm_Homo sapiens_hsa047100.13005444
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12801618
110Insulin signaling pathway_Homo sapiens_hsa049100.11534987
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10781943
112Fatty acid biosynthesis_Homo sapiens_hsa000610.10359971
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.10132055
114Peroxisome_Homo sapiens_hsa041460.10026715
115Galactose metabolism_Homo sapiens_hsa000520.09369366
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.07593669
117Renal cell carcinoma_Homo sapiens_hsa052110.06014614
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.06008539
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.05693995
120Ether lipid metabolism_Homo sapiens_hsa005650.05283953
121Starch and sucrose metabolism_Homo sapiens_hsa005000.05272336
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.04876733
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.04681974
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.04460361
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.03852306
126Wnt signaling pathway_Homo sapiens_hsa043100.03596041
127AMPK signaling pathway_Homo sapiens_hsa041520.02122347
128Retinol metabolism_Homo sapiens_hsa008300.01342237
129Melanoma_Homo sapiens_hsa05218-0.0051227

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