OTUD7A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a deubiquitinizing enzyme and possible tumor suppressor. The encoded protein acts on TNF receptor associated factor 6 (TRAF6) to control nuclear factor kappa B expression. However, this gene is downregulated by SNAIL1 in hepatocellular carcinoma cells, contributing to their progression and malignancy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.32397954
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.28622642
3synaptic vesicle maturation (GO:0016188)6.19770865
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.89629172
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.49296405
6vocalization behavior (GO:0071625)5.44797887
7central nervous system myelination (GO:0022010)5.43218366
8axon ensheathment in central nervous system (GO:0032291)5.43218366
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.40555332
10glutamate secretion (GO:0014047)5.29994261
11synaptic vesicle exocytosis (GO:0016079)5.28454366
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.19867909
13regulation of synaptic vesicle exocytosis (GO:2000300)5.09438715
14regulation of glutamate receptor signaling pathway (GO:1900449)4.96399569
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.76613029
16protein localization to synapse (GO:0035418)4.66412487
17exploration behavior (GO:0035640)4.65459820
18neuronal action potential propagation (GO:0019227)4.57605293
19regulation of synaptic vesicle transport (GO:1902803)4.57407292
20presynaptic membrane organization (GO:0097090)4.56554867
21layer formation in cerebral cortex (GO:0021819)4.53842575
22regulation of neuronal synaptic plasticity (GO:0048168)4.53171024
23presynaptic membrane assembly (GO:0097105)4.47899425
24neurotransmitter secretion (GO:0007269)4.46924462
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.43168301
26synaptic transmission, glutamatergic (GO:0035249)4.36944363
27neuron cell-cell adhesion (GO:0007158)4.36451444
28regulation of synapse structural plasticity (GO:0051823)4.36443962
29glutamate receptor signaling pathway (GO:0007215)4.30522346
30neurotransmitter-gated ion channel clustering (GO:0072578)4.22767880
31amino acid import (GO:0043090)4.20631501
32dendritic spine morphogenesis (GO:0060997)4.14013720
33cellular potassium ion homeostasis (GO:0030007)4.11335311
34auditory behavior (GO:0031223)4.05065272
35gamma-aminobutyric acid transport (GO:0015812)4.02978772
36neuron-neuron synaptic transmission (GO:0007270)3.98021796
37positive regulation of membrane potential (GO:0045838)3.94068239
38positive regulation of synapse maturation (GO:0090129)3.92402839
39long-term memory (GO:0007616)3.89069190
40sodium ion export (GO:0071436)3.87944923
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87459538
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.86691599
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85906829
44proline transport (GO:0015824)3.84100053
45neuromuscular process controlling balance (GO:0050885)3.75966157
46response to auditory stimulus (GO:0010996)3.72816921
47regulation of dendritic spine morphogenesis (GO:0061001)3.70437392
48cerebellar Purkinje cell differentiation (GO:0021702)3.68256111
49potassium ion homeostasis (GO:0055075)3.67944076
50regulation of postsynaptic membrane potential (GO:0060078)3.64545147
51regulation of synaptic plasticity (GO:0048167)3.63739848
52neurotransmitter transport (GO:0006836)3.58762524
53negative regulation of dendrite morphogenesis (GO:0050774)3.58013133
54activation of protein kinase A activity (GO:0034199)3.57861372
55transmission of nerve impulse (GO:0019226)3.55434858
56regulation of neurotransmitter secretion (GO:0046928)3.55027437
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.51868280
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.51638690
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.51552176
60synaptic vesicle endocytosis (GO:0048488)3.51378835
61glycine transport (GO:0015816)3.50543678
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46730589
63neurotransmitter uptake (GO:0001504)3.45461948
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.40927206
65innervation (GO:0060384)3.40925001
66long-term synaptic potentiation (GO:0060291)3.39745174
67cellular sodium ion homeostasis (GO:0006883)3.37402758
68startle response (GO:0001964)3.36738696
69acidic amino acid transport (GO:0015800)3.35405732
70dendrite morphogenesis (GO:0048813)3.34747577
71regulation of neurotransmitter levels (GO:0001505)3.33126304
72cell communication by electrical coupling (GO:0010644)3.32161486
73prepulse inhibition (GO:0060134)3.27985807
74positive regulation of neurotransmitter secretion (GO:0001956)3.27525522
75L-amino acid import (GO:0043092)3.26877625
76neuron recognition (GO:0008038)3.26202464
77mechanosensory behavior (GO:0007638)3.25684463
78regulation of neurotransmitter transport (GO:0051588)3.24807078
79membrane depolarization during action potential (GO:0086010)3.23775216
80regulation of vesicle fusion (GO:0031338)3.21162879
81neuromuscular process controlling posture (GO:0050884)3.20800322
82gamma-aminobutyric acid signaling pathway (GO:0007214)3.20521672
83membrane depolarization (GO:0051899)3.19997970
84adult walking behavior (GO:0007628)3.19977588
85postsynaptic membrane organization (GO:0001941)3.19384145
86cerebellar granule cell differentiation (GO:0021707)3.18435150
87regulation of ARF protein signal transduction (GO:0032012)3.18017332
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17095121
89membrane hyperpolarization (GO:0060081)3.16913031
90neuromuscular process (GO:0050905)3.16663530
91positive regulation of neurotransmitter transport (GO:0051590)3.15631948
92negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13586290
93positive regulation of synaptic transmission, GABAergic (GO:0032230)3.12277971
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11274679
95neuronal ion channel clustering (GO:0045161)3.10852337
96C4-dicarboxylate transport (GO:0015740)3.09215169
97positive regulation of dendritic spine morphogenesis (GO:0061003)3.09163977
98dendritic spine organization (GO:0097061)3.08850952
99serotonin metabolic process (GO:0042428)3.07896409
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05362934
101synapse assembly (GO:0007416)3.05104253
102axonal fasciculation (GO:0007413)3.04932165
103neuromuscular synaptic transmission (GO:0007274)3.03867875
104regulation of dendritic spine development (GO:0060998)3.01268180
105regulation of synaptic transmission (GO:0050804)3.01149507
106L-glutamate transport (GO:0015813)3.01030225
107regulation of voltage-gated calcium channel activity (GO:1901385)3.00678368
108learning (GO:0007612)3.00279695
109G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98051378
110positive regulation of synaptic transmission (GO:0050806)2.97445746
111detection of calcium ion (GO:0005513)2.95842971
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94029153
113synaptic transmission (GO:0007268)2.93490285
114vesicle transport along microtubule (GO:0047496)2.93188910
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91817382
116potassium ion import (GO:0010107)2.91736099
117positive regulation of dendritic spine development (GO:0060999)2.91399530
118regulation of synapse maturation (GO:0090128)2.90076441
119chemosensory behavior (GO:0007635)2.89869428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58823942
2GBX2_23144817_ChIP-Seq_PC3_Human3.21971334
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10193797
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05314769
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04598610
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.81061722
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74674900
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74674900
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.70687373
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69942452
11* DROSHA_22980978_ChIP-Seq_HELA_Human2.65074288
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58269803
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55851329
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55668747
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49289796
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.45218978
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42513299
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.31320886
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29521148
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.28078502
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.27329791
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.26772202
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.20864969
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13167790
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08268430
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06932953
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06533437
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86798802
29AR_21572438_ChIP-Seq_LNCaP_Human1.83994164
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82845138
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.66307039
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63815872
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62474303
34SMAD4_21799915_ChIP-Seq_A2780_Human1.55512813
35ZNF274_21170338_ChIP-Seq_K562_Hela1.38353145
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36205747
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34881065
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.34806453
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33295788
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29518431
41SOX2_21211035_ChIP-Seq_LN229_Gbm1.29366187
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27255443
43KDM2B_26808549_Chip-Seq_K562_Human1.26385065
44* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26126215
45* AR_19668381_ChIP-Seq_PC3_Human1.26063092
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23486433
47* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22750714
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21613082
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20843295
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.20793932
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20787345
52STAT3_23295773_ChIP-Seq_U87_Human1.17974413
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14448857
54AR_25329375_ChIP-Seq_VCAP_Human1.13931489
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13899339
56TAF15_26573619_Chip-Seq_HEK293_Human1.13815803
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.11872773
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11833160
59P300_19829295_ChIP-Seq_ESCs_Human1.10684017
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10596109
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.10009337
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09216129
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.06631022
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05314181
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04365500
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04338427
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04338427
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03749245
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03361433
70* TCF4_23295773_ChIP-Seq_U87_Human1.03277993
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03207912
72AHR_22903824_ChIP-Seq_MCF-7_Human1.02746808
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02689569
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01496138
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01008146
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.00910024
77* SMAD3_21741376_ChIP-Seq_ESCs_Human1.00865503
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.00203604
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99832099
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99372439
81CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99041389
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98023059
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97813840
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97752800
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97162274
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96628319
87SMAD3_21741376_ChIP-Seq_HESCs_Human0.95131607
88RXR_22108803_ChIP-Seq_LS180_Human0.94478914
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94318248
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94297261
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93888809
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93496387
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92971608
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92680344
95ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91981108
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.91677896
97GATA1_26923725_Chip-Seq_HPCs_Mouse0.91620050
98TET1_21490601_ChIP-Seq_MESCs_Mouse0.90848873
99KDM2B_26808549_Chip-Seq_REH_Human0.90186261
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90102830
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89219709
102RNF2_27304074_Chip-Seq_NSC_Mouse0.88130356
103POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88092925
104SOX9_26525672_Chip-Seq_HEART_Mouse0.87327289
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87314300
106CTCF_27219007_Chip-Seq_Bcells_Human0.86989891
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86794381
108BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86239968
109* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84917671
110CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84459262
111IGF1R_20145208_ChIP-Seq_DFB_Human0.84075894
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83922989
113RUNX2_22187159_ChIP-Seq_PCA_Human0.83909810
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83205093
115PRDM14_20953172_ChIP-Seq_ESCs_Human0.82995923
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82914723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.09234085
2MP0003880_abnormal_central_pattern4.52719925
3MP0003635_abnormal_synaptic_transmissio4.30808078
4MP0004270_analgesia3.95182956
5MP0009745_abnormal_behavioral_response3.44891124
6MP0002063_abnormal_learning/memory/cond3.40440382
7MP0002064_seizures3.23330927
8MP0009046_muscle_twitch3.18815434
9MP0001968_abnormal_touch/_nociception3.04364569
10MP0005423_abnormal_somatic_nervous2.88799391
11MP0002572_abnormal_emotion/affect_behav2.79273753
12MP0002734_abnormal_mechanical_nocicepti2.73214319
13MP0002272_abnormal_nervous_system2.67208671
14MP0001486_abnormal_startle_reflex2.64914974
15MP0002822_catalepsy2.57694595
16MP0002736_abnormal_nociception_after2.45184473
17MP0008569_lethality_at_weaning2.20866470
18MP0002735_abnormal_chemical_nociception2.20238344
19MP0001501_abnormal_sleep_pattern2.18127326
20MP0001440_abnormal_grooming_behavior2.06319007
21MP0004858_abnormal_nervous_system2.05840122
22MP0009780_abnormal_chondrocyte_physiolo2.03888733
23MP0002733_abnormal_thermal_nociception2.02873352
24MP0001970_abnormal_pain_threshold1.97109068
25MP0002067_abnormal_sensory_capabilities1.96704517
26MP0003329_amyloid_beta_deposits1.93830216
27MP0004811_abnormal_neuron_physiology1.86227284
28MP0002184_abnormal_innervation1.84679875
29MP0000778_abnormal_nervous_system1.78110220
30MP0002909_abnormal_adrenal_gland1.75777745
31MP0002557_abnormal_social/conspecific_i1.68441329
32MP0005646_abnormal_pituitary_gland1.68040388
33MP0000955_abnormal_spinal_cord1.66607531
34MP0005386_behavior/neurological_phenoty1.65427832
35MP0004924_abnormal_behavior1.65427832
36MP0003879_abnormal_hair_cell1.63703201
37MP0008877_abnormal_DNA_methylation1.60797207
38MP0004885_abnormal_endolymph1.59592486
39MP0003633_abnormal_nervous_system1.48641669
40MP0002066_abnormal_motor_capabilities/c1.46442698
41MP0002882_abnormal_neuron_morphology1.45878821
42MP0001984_abnormal_olfaction1.44528467
43MP0001502_abnormal_circadian_rhythm1.42401247
44MP0003283_abnormal_digestive_organ1.39065003
45MP0003631_nervous_system_phenotype1.29123013
46MP0004142_abnormal_muscle_tone1.26320248
47MP0003123_paternal_imprinting1.25615602
48MP0003787_abnormal_imprinting1.17969488
49MP0005645_abnormal_hypothalamus_physiol1.14940062
50MP0008961_abnormal_basal_metabolism1.13238199
51MP0002152_abnormal_brain_morphology1.12658389
52MP0000920_abnormal_myelination1.09277423
53MP0001177_atelectasis1.03784823
54MP0003690_abnormal_glial_cell1.03625474
55MP0003632_abnormal_nervous_system1.03270937
56MP0002638_abnormal_pupillary_reflex1.03237296
57MP0004145_abnormal_muscle_electrophysio1.02376966
58MP0006276_abnormal_autonomic_nervous1.02014999
59MP0003075_altered_response_to1.01404677
60MP0010234_abnormal_vibrissa_follicle1.01066500
61MP0002229_neurodegeneration0.99437407
62MP0001905_abnormal_dopamine_level0.99301691
63MP0003634_abnormal_glial_cell0.98076259
64MP0004742_abnormal_vestibular_system0.97737641
65MP0008872_abnormal_physiological_respon0.95304600
66MP0001529_abnormal_vocalization0.92789812
67MP0005551_abnormal_eye_electrophysiolog0.91958160
68MP0002069_abnormal_eating/drinking_beha0.90675290
69MP0000569_abnormal_digit_pigmentation0.90459930
70MP0004147_increased_porphyrin_level0.86627015
71MP0000604_amyloidosis0.86465631
72MP0008874_decreased_physiological_sensi0.85904014
73MP0001963_abnormal_hearing_physiology0.80526759
74MP0000751_myopathy0.78718905
75MP0003122_maternal_imprinting0.78207197
76MP0005167_abnormal_blood-brain_barrier0.76198766
77MP0002752_abnormal_somatic_nervous0.74991092
78MP0004043_abnormal_pH_regulation0.73286279
79MP0010386_abnormal_urinary_bladder0.73095242
80MP0001986_abnormal_taste_sensitivity0.72641021
81MP0004085_abnormal_heartbeat0.71581226
82MP0005535_abnormal_body_temperature0.71549702
83MP0005394_taste/olfaction_phenotype0.70340721
84MP0005499_abnormal_olfactory_system0.70340721
85MP0005174_abnormal_tail_pigmentation0.69949747
86MP0000631_abnormal_neuroendocrine_gland0.68536401
87MP0003172_abnormal_lysosome_physiology0.68336912
88MP0001485_abnormal_pinna_reflex0.67657450
89MP0002090_abnormal_vision0.66215094
90MP0004130_abnormal_muscle_cell0.65565202
91MP0000013_abnormal_adipose_tissue0.65156037
92MP0005187_abnormal_penis_morphology0.65141831
93MP0003137_abnormal_impulse_conducting0.64132412
94MP0000015_abnormal_ear_pigmentation0.64026288
95MP0004484_altered_response_of0.63903328
96MP0000026_abnormal_inner_ear0.62963119
97MP0005623_abnormal_meninges_morphology0.62377066
98MP0001299_abnormal_eye_distance/0.62333913
99MP0004233_abnormal_muscle_weight0.61514747
100MP0003121_genomic_imprinting0.60664547
101MP0005171_absent_coat_pigmentation0.60544589
102MP0005410_abnormal_fertilization0.60387432
103MP0001346_abnormal_lacrimal_gland0.59268601
104MP0004215_abnormal_myocardial_fiber0.57544071
105MP0003861_abnormal_nervous_system0.56757276
106MP0010770_preweaning_lethality0.56149858
107MP0002082_postnatal_lethality0.56149858
108MP0010768_mortality/aging0.56029246
109MP0002876_abnormal_thyroid_physiology0.55656113
110MP0003045_fibrosis0.55063124
111MP0010769_abnormal_survival0.54593304
112MP0001188_hyperpigmentation0.54118536
113MP0001348_abnormal_lacrimal_gland0.54091376
114MP0004510_myositis0.53563009
115MP0001664_abnormal_digestion0.52544941
116MP0001943_abnormal_respiration0.52396839
117MP0003956_abnormal_body_size0.46967335
118MP0003698_abnormal_male_reproductive0.44770267

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.31991487
2Focal motor seizures (HP:0011153)7.26849956
3Focal seizures (HP:0007359)5.65283185
4Visual hallucinations (HP:0002367)5.30645432
5Action tremor (HP:0002345)4.73715625
6Epileptic encephalopathy (HP:0200134)4.59570981
7Progressive cerebellar ataxia (HP:0002073)4.41689772
8Febrile seizures (HP:0002373)4.34920651
9Atonic seizures (HP:0010819)4.19833237
10Supranuclear gaze palsy (HP:0000605)3.87965508
11Absence seizures (HP:0002121)3.85045338
12Generalized tonic-clonic seizures (HP:0002069)3.74690113
13Ankle clonus (HP:0011448)3.68360557
14Impaired vibration sensation in the lower limbs (HP:0002166)3.62890136
15Gaze-evoked nystagmus (HP:0000640)3.59616148
16Dialeptic seizures (HP:0011146)3.53047582
17Dysmetria (HP:0001310)3.39353008
18Broad-based gait (HP:0002136)3.36402184
19Limb dystonia (HP:0002451)3.36266006
20Dysdiadochokinesis (HP:0002075)3.34970251
21Urinary bladder sphincter dysfunction (HP:0002839)3.34893393
22Postural instability (HP:0002172)3.29080441
23Poor eye contact (HP:0000817)3.25973944
24Depression (HP:0000716)3.24776855
25Cerebral hypomyelination (HP:0006808)3.21058751
26Abnormality of the lower motor neuron (HP:0002366)3.19826110
27Truncal ataxia (HP:0002078)3.12849210
28Mutism (HP:0002300)3.06342282
29Spastic gait (HP:0002064)3.01347597
30Anxiety (HP:0000739)3.01105497
31Impaired smooth pursuit (HP:0007772)2.95792542
32Abnormal social behavior (HP:0012433)2.93678567
33Impaired social interactions (HP:0000735)2.93678567
34Intention tremor (HP:0002080)2.92338866
35Urinary urgency (HP:0000012)2.88801247
36Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.84151882
37Ventricular fibrillation (HP:0001663)2.79475056
38Hemiplegia (HP:0002301)2.79288485
39Torticollis (HP:0000473)2.76850286
40Hemiparesis (HP:0001269)2.75104034
41Papilledema (HP:0001085)2.75087325
42Genetic anticipation (HP:0003743)2.74868248
43Hyperventilation (HP:0002883)2.72829643
44Megalencephaly (HP:0001355)2.72802563
45Scanning speech (HP:0002168)2.69045723
46Neurofibrillary tangles (HP:0002185)2.67623426
47Abnormal eating behavior (HP:0100738)2.66878137
48Amblyopia (HP:0000646)2.59863419
49Abnormality of ocular smooth pursuit (HP:0000617)2.57465154
50Annular pancreas (HP:0001734)2.56695133
51Abnormality of binocular vision (HP:0011514)2.55578696
52Diplopia (HP:0000651)2.55578696
53Cerebral inclusion bodies (HP:0100314)2.55454745
54Focal dystonia (HP:0004373)2.53893444
55Abnormality of the corticospinal tract (HP:0002492)2.52122554
56Bradykinesia (HP:0002067)2.49366431
57Impaired vibratory sensation (HP:0002495)2.47121115
58Stereotypic behavior (HP:0000733)2.46252907
59Dysmetric saccades (HP:0000641)2.44272296
60Delusions (HP:0000746)2.44055347
61Drooling (HP:0002307)2.43893955
62Excessive salivation (HP:0003781)2.43893955
63Spastic tetraparesis (HP:0001285)2.43549339
64Lower limb muscle weakness (HP:0007340)2.42188298
65Akinesia (HP:0002304)2.38431119
66Peripheral hypomyelination (HP:0007182)2.38040601
67Fetal akinesia sequence (HP:0001989)2.37821719
68Termporal pattern (HP:0011008)2.35950008
69Insidious onset (HP:0003587)2.35950008
70Pointed chin (HP:0000307)2.35929981
71Sleep apnea (HP:0010535)2.34968272
72Polyphagia (HP:0002591)2.34646613
73Progressive inability to walk (HP:0002505)2.33904983
74Epileptiform EEG discharges (HP:0011182)2.33385720
75Insomnia (HP:0100785)2.30635968
76EEG with generalized epileptiform discharges (HP:0011198)2.27132784
77Morphological abnormality of the pyramidal tract (HP:0002062)2.26162325
78Craniofacial dystonia (HP:0012179)2.23535215
79Absent speech (HP:0001344)2.20921752
80Status epilepticus (HP:0002133)2.20702682
81Bundle branch block (HP:0011710)2.18955359
82Clonus (HP:0002169)2.18557331
83Hypsarrhythmia (HP:0002521)2.17158983
84Increased circulating renin level (HP:0000848)2.14848212
85Gait ataxia (HP:0002066)2.12227340
86Pheochromocytoma (HP:0002666)2.09178851
87Incomplete penetrance (HP:0003829)2.04398635
88Abnormality of saccadic eye movements (HP:0000570)2.04290551
89Neuronal loss in central nervous system (HP:0002529)2.01461986
90Choreoathetosis (HP:0001266)2.00993855
91Resting tremor (HP:0002322)2.00854060
92Split foot (HP:0001839)1.99151071
93Agitation (HP:0000713)1.97024536
94Aqueductal stenosis (HP:0002410)1.95421296
95CNS hypomyelination (HP:0003429)1.94769550
96Obstructive sleep apnea (HP:0002870)1.93988879
97Inability to walk (HP:0002540)1.92977355
98Generalized myoclonic seizures (HP:0002123)1.90548089
99Aplasia involving bones of the upper limbs (HP:0009823)1.90056344
100Aplasia of the phalanges of the hand (HP:0009802)1.90056344
101Aplasia involving bones of the extremities (HP:0009825)1.90056344
102Abnormality of the periventricular white matter (HP:0002518)1.86314528
103Neuroendocrine neoplasm (HP:0100634)1.82355758
104Amyotrophic lateral sclerosis (HP:0007354)1.81679489
105Abnormal EKG (HP:0003115)1.81567866
106Spastic tetraplegia (HP:0002510)1.81116105
107Neoplasm of the peripheral nervous system (HP:0100007)1.80952446
108Rigidity (HP:0002063)1.80483556
109Lower limb asymmetry (HP:0100559)1.80337913
110Apathy (HP:0000741)1.80293763
111Paraplegia (HP:0010550)1.79068610
112Lower limb amyotrophy (HP:0007210)1.77465182
113Spastic paraplegia (HP:0001258)1.77448531
114Blue irides (HP:0000635)1.77222644
115Anosmia (HP:0000458)1.76119835
116Tetraplegia (HP:0002445)1.74292202
117Rapidly progressive (HP:0003678)1.74147642
118Ankyloglossia (HP:0010296)1.72866909
119Hypoplasia of the corpus callosum (HP:0002079)1.72559514
120Iris hypopigmentation (HP:0007730)1.70456745
121Protruding tongue (HP:0010808)1.69910217
122Thickened helices (HP:0000391)1.69885475
123Degeneration of the lateral corticospinal tracts (HP:0002314)1.69701170
124Alacrima (HP:0000522)1.67936474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.38668749
2EPHA44.25448141
3MAP3K93.82153351
4MAP3K42.90378976
5MARK12.90211431
6DAPK22.84556215
7PRKD32.74720212
8MINK12.67813046
9PAK62.52016793
10NTRK22.33730569
11MAP2K72.21274571
12KSR22.19766427
13CAMKK12.17148673
14NTRK12.06429894
15STK381.80317204
16MAP2K41.71638156
17RIPK41.69270344
18CDK51.62359290
19RIPK11.50492555
20DAPK11.45253594
21MAP3K121.40945434
22KSR11.40251138
23CDK191.37831080
24TNIK1.36958440
25PRPF4B1.35874697
26MAP3K21.27931578
27PNCK1.25254775
28TYRO31.24748971
29PINK11.24381998
30GRK51.22721934
31PRKCG1.22689061
32LMTK21.22395485
33FRK1.19198671
34MAPK131.18133781
35CAMKK21.17802961
36CASK1.16074512
37UHMK11.12058342
38TAOK11.11439694
39PLK21.10944545
40STK111.09538165
41SIK21.04473908
42ARAF1.03798077
43MAP3K131.03166767
44PHKG11.02487297
45PHKG21.02487297
46FES1.00630817
47CAMK10.98201523
48PRKCH0.94080652
49LATS20.93338523
50ALK0.91946239
51SGK2230.90223854
52SGK4940.90223854
53RET0.87833530
54CAMK2A0.87571830
55CDK150.86661276
56CDK180.86022319
57OXSR10.82203484
58NEK10.82007130
59CDK140.80488698
60MAPK120.78111752
61PAK30.75427287
62MARK20.74405462
63CDK11A0.74257424
64PDK10.70671127
65SGK10.69872770
66RAF10.68928568
67WNK10.68900593
68PTK2B0.67787950
69CAMK2B0.67356509
70SGK20.65336681
71CSNK1G20.64814441
72SGK30.64621648
73PDPK10.64554909
74MAP3K10.63257132
75TNK20.61410468
76DYRK1A0.61129580
77SCYL20.59915819
78CAMK1G0.59871424
79BMPR20.57701524
80CDC42BPA0.55802486
81MAP3K70.54007111
82RPS6KA30.53324921
83NEK60.52917598
84PRKCZ0.51949213
85FYN0.49621836
86FER0.47796818
87IRAK20.47364509
88BRSK10.47219382
89CAMK40.46268026
90MAPK100.46065401
91PRKCE0.43686567
92CAMK2G0.43193792
93FGFR20.42645484
94DAPK30.42378324
95PRKG10.42094115
96PDGFRA0.41181817
97PRKCA0.40714256
98STK390.39776791
99LIMK10.39642510
100MAP3K110.38702887
101CAMK2D0.38406215
102PRKD20.37409127
103ICK0.36680450
104CSNK1D0.36194870
105PRKACA0.33850770
106CCNB10.33086189
107PKN10.32657391
108ROCK20.32526503
109PRKCB0.32495793
110ERBB20.31786960
111MAPK80.31769191
112MAPKAPK50.30166749
113DYRK20.28615835

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.42782590
2Synaptic vesicle cycle_Homo sapiens_hsa047213.25890563
3Olfactory transduction_Homo sapiens_hsa047402.78476515
4Circadian entrainment_Homo sapiens_hsa047132.74714630
5Glutamatergic synapse_Homo sapiens_hsa047242.65105622
6Long-term potentiation_Homo sapiens_hsa047202.63331140
7GABAergic synapse_Homo sapiens_hsa047272.59955437
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55919633
9Morphine addiction_Homo sapiens_hsa050322.41908166
10Amphetamine addiction_Homo sapiens_hsa050312.38294995
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29628708
12Salivary secretion_Homo sapiens_hsa049702.22515154
13Insulin secretion_Homo sapiens_hsa049112.14935589
14Dopaminergic synapse_Homo sapiens_hsa047282.06185209
15Gastric acid secretion_Homo sapiens_hsa049711.95295664
16Cholinergic synapse_Homo sapiens_hsa047251.94350977
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89709871
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73311295
19Long-term depression_Homo sapiens_hsa047301.67483649
20Taste transduction_Homo sapiens_hsa047421.66129642
21Renin secretion_Homo sapiens_hsa049241.62980602
22Oxytocin signaling pathway_Homo sapiens_hsa049211.61187539
23Calcium signaling pathway_Homo sapiens_hsa040201.58198580
24Nitrogen metabolism_Homo sapiens_hsa009101.54841259
25Cocaine addiction_Homo sapiens_hsa050301.52512115
26GnRH signaling pathway_Homo sapiens_hsa049121.47577430
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47505753
28Serotonergic synapse_Homo sapiens_hsa047261.46846247
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40262182
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35235146
31Gap junction_Homo sapiens_hsa045401.34603583
32Type II diabetes mellitus_Homo sapiens_hsa049301.34460556
33cAMP signaling pathway_Homo sapiens_hsa040241.30340195
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25534127
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24698872
36Glioma_Homo sapiens_hsa052141.20686056
37Estrogen signaling pathway_Homo sapiens_hsa049151.16502505
38Collecting duct acid secretion_Homo sapiens_hsa049661.15467829
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12647322
40Vitamin B6 metabolism_Homo sapiens_hsa007501.11671266
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06168210
42ErbB signaling pathway_Homo sapiens_hsa040121.04989662
43Axon guidance_Homo sapiens_hsa043601.02782457
44Melanogenesis_Homo sapiens_hsa049161.01287069
45Pancreatic secretion_Homo sapiens_hsa049720.98083354
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.96662418
47Oocyte meiosis_Homo sapiens_hsa041140.96649606
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.94590429
49Dorso-ventral axis formation_Homo sapiens_hsa043200.91479129
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89750677
51Thyroid hormone synthesis_Homo sapiens_hsa049180.85004088
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83988462
53Cardiac muscle contraction_Homo sapiens_hsa042600.81986309
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80773848
55Vibrio cholerae infection_Homo sapiens_hsa051100.76969434
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76961275
57Dilated cardiomyopathy_Homo sapiens_hsa054140.75458756
58Choline metabolism in cancer_Homo sapiens_hsa052310.73444667
59MAPK signaling pathway_Homo sapiens_hsa040100.70065781
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70058565
61Phototransduction_Homo sapiens_hsa047440.69237014
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.67287894
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64639008
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64510451
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63298567
66Histidine metabolism_Homo sapiens_hsa003400.63247848
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.59729872
68VEGF signaling pathway_Homo sapiens_hsa043700.59453493
69Bile secretion_Homo sapiens_hsa049760.59249347
70mTOR signaling pathway_Homo sapiens_hsa041500.58990866
71Rap1 signaling pathway_Homo sapiens_hsa040150.58878683
72Endocytosis_Homo sapiens_hsa041440.58577908
73Ras signaling pathway_Homo sapiens_hsa040140.57801077
74Inositol phosphate metabolism_Homo sapiens_hsa005620.57342193
75Glucagon signaling pathway_Homo sapiens_hsa049220.54904374
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49414263
77Fatty acid biosynthesis_Homo sapiens_hsa000610.47420484
78Ether lipid metabolism_Homo sapiens_hsa005650.46994238
79Endometrial cancer_Homo sapiens_hsa052130.46824446
80Type I diabetes mellitus_Homo sapiens_hsa049400.45973455
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45801695
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45785292
83Alcoholism_Homo sapiens_hsa050340.45662247
84beta-Alanine metabolism_Homo sapiens_hsa004100.45134704
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43296202
86Non-small cell lung cancer_Homo sapiens_hsa052230.43287114
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43160123
88Circadian rhythm_Homo sapiens_hsa047100.41830333
89Mineral absorption_Homo sapiens_hsa049780.41645115
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41396115
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39668144
92Chemokine signaling pathway_Homo sapiens_hsa040620.39236200
93Wnt signaling pathway_Homo sapiens_hsa043100.38464815
94Arginine and proline metabolism_Homo sapiens_hsa003300.37569491
95Prion diseases_Homo sapiens_hsa050200.37246722
96Butanoate metabolism_Homo sapiens_hsa006500.37133296
97Renal cell carcinoma_Homo sapiens_hsa052110.36706176
98Insulin signaling pathway_Homo sapiens_hsa049100.36273530
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35742740
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35489060
101ABC transporters_Homo sapiens_hsa020100.34888318
102Ovarian steroidogenesis_Homo sapiens_hsa049130.34447451
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.32570599
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31189267
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30672074
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30214756
107Regulation of autophagy_Homo sapiens_hsa041400.29848203
108African trypanosomiasis_Homo sapiens_hsa051430.27453505
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27387129
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26050655
111Tight junction_Homo sapiens_hsa045300.24923161
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21666198
113AMPK signaling pathway_Homo sapiens_hsa041520.19234675

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