OTUD7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.01025728
2central nervous system myelination (GO:0022010)9.01025728
3serotonin receptor signaling pathway (GO:0007210)6.01911665
4axon ensheathment (GO:0008366)5.91873592
5ensheathment of neurons (GO:0007272)5.91873592
6myelination (GO:0042552)5.84049559
7positive regulation of osteoblast proliferation (GO:0033690)5.68410228
8fatty acid elongation (GO:0030497)5.59813809
9myelin maintenance (GO:0043217)5.31670678
10lymphangiogenesis (GO:0001946)5.18509394
11regulation of appetite (GO:0032098)4.99545548
12positive regulation of hair cycle (GO:0042635)4.73573166
13positive regulation of hair follicle development (GO:0051798)4.73573166
14cysteine metabolic process (GO:0006534)4.68517241
15carnitine transmembrane transport (GO:1902603)4.57670094
16hematopoietic stem cell proliferation (GO:0071425)4.56898715
17negative regulation of circadian rhythm (GO:0042754)4.50956835
18angiogenesis involved in wound healing (GO:0060055)4.41045138
19sulfation (GO:0051923)4.34715718
20carnitine metabolic process (GO:0009437)4.34599530
21photoreceptor cell differentiation (GO:0046530)4.31425229
22eye photoreceptor cell differentiation (GO:0001754)4.31425229
23thyroid hormone metabolic process (GO:0042403)4.24824840
24amino-acid betaine transport (GO:0015838)4.23236568
25carnitine transport (GO:0015879)4.23236568
26negative regulation of protein localization to cell surface (GO:2000009)4.22039737
27paraxial mesoderm development (GO:0048339)4.18451417
28negative regulation of calcium ion transport into cytosol (GO:0010523)4.12045202
29omega-hydroxylase P450 pathway (GO:0097267)4.11615987
30negative regulation of neurotransmitter secretion (GO:0046929)4.05683172
31long-chain fatty acid biosynthetic process (GO:0042759)3.99346916
32tryptophan catabolic process (GO:0006569)3.99260226
33indole-containing compound catabolic process (GO:0042436)3.99260226
34indolalkylamine catabolic process (GO:0046218)3.99260226
35creatine metabolic process (GO:0006600)3.99084182
36meiotic chromosome segregation (GO:0045132)3.97945446
37regulation of Cdc42 GTPase activity (GO:0043088)3.94885016
38asymmetric protein localization (GO:0008105)3.90854937
39import into cell (GO:0098657)3.88905414
40rRNA catabolic process (GO:0016075)3.87397671
41glycoprotein catabolic process (GO:0006516)3.86163600
42peptidyl-tyrosine autophosphorylation (GO:0038083)3.86154959
43amino-acid betaine metabolic process (GO:0006577)3.86120044
44L-amino acid import (GO:0043092)3.82714176
45peptidyl-threonine dephosphorylation (GO:0035970)3.77169963
46apical protein localization (GO:0045176)3.75873054
47myelination in peripheral nervous system (GO:0022011)3.74273563
48peripheral nervous system axon ensheathment (GO:0032292)3.74273563
49protein localization to endosome (GO:0036010)3.72697653
50organic cation transport (GO:0015695)3.68936442
51flavonoid metabolic process (GO:0009812)3.68791363
52homocysteine metabolic process (GO:0050667)3.67581194
53regulation of sarcomere organization (GO:0060297)3.66168595
54phospholipid translocation (GO:0045332)3.64602967
55lipid translocation (GO:0034204)3.64602967
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61559624
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.59550536
58response to methylmercury (GO:0051597)3.59029281
59interferon-gamma production (GO:0032609)3.58228966
60reflex (GO:0060004)3.56369283
61startle response (GO:0001964)3.56341945
62astrocyte development (GO:0014002)3.48396546
63righting reflex (GO:0060013)3.47620673
64negative regulation of neurotransmitter transport (GO:0051589)3.45818371
65negative regulation of hormone biosynthetic process (GO:0032353)3.43551870
66quaternary ammonium group transport (GO:0015697)3.40557542
67purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.40382514
683-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.40382514
69oligodendrocyte differentiation (GO:0048709)3.39781883
70negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.37681083
71regulation of hippo signaling (GO:0035330)3.35500351
72cilium or flagellum-dependent cell motility (GO:0001539)3.34972817
73granulocyte differentiation (GO:0030851)3.26240141
74regulation of collateral sprouting (GO:0048670)3.25413967
75membrane tubulation (GO:0097320)3.22518059
76cellular ketone body metabolic process (GO:0046950)3.19289498
77biotin metabolic process (GO:0006768)3.16831002
78phosphatidylinositol acyl-chain remodeling (GO:0036149)3.15627761
79negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.14354406
80sex differentiation (GO:0007548)3.13047919
81regulation of hair follicle development (GO:0051797)3.11935039
82establishment of mitochondrion localization (GO:0051654)3.08833460
83regulation of lipoprotein metabolic process (GO:0050746)3.07932588
84response to lipoprotein particle (GO:0055094)3.07490468
85tryptophan metabolic process (GO:0006568)3.05187706
86killing of cells of other organism (GO:0031640)3.03647571
87disruption of cells of other organism (GO:0044364)3.03647571
88phosphatidylserine acyl-chain remodeling (GO:0036150)3.02837118
89phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.02306023
90long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.01240196
91cholesterol biosynthetic process (GO:0006695)3.00419657
92nephron tubule morphogenesis (GO:0072078)2.96558843
93nephron epithelium morphogenesis (GO:0072088)2.96558843
94adhesion of symbiont to host cell (GO:0044650)2.96313528
95virion attachment to host cell (GO:0019062)2.96313528
96negative regulation of metanephros development (GO:0072217)2.96244424
97detection of light stimulus involved in sensory perception (GO:0050962)2.96129089
98detection of light stimulus involved in visual perception (GO:0050908)2.96129089
99glycerophospholipid catabolic process (GO:0046475)2.94130716
100ketone body metabolic process (GO:1902224)2.93695619
101negative regulation of hormone metabolic process (GO:0032351)2.93066853
102establishment of protein localization to Golgi (GO:0072600)2.93003409
103activated T cell proliferation (GO:0050798)2.90350017
104protein K6-linked ubiquitination (GO:0085020)2.86721692
105* protein K11-linked deubiquitination (GO:0035871)2.86479681
106cytoskeletal anchoring at plasma membrane (GO:0007016)2.85851929
107nerve growth factor signaling pathway (GO:0038180)2.85507251
108androgen biosynthetic process (GO:0006702)2.80387789
109synaptic vesicle docking involved in exocytosis (GO:0016081)2.80221992
110amyloid precursor protein metabolic process (GO:0042982)2.79802082
111filopodium assembly (GO:0046847)2.75990983
112amino acid import (GO:0043090)2.75359735
113striated muscle atrophy (GO:0014891)2.74502929
114kynurenine metabolic process (GO:0070189)2.72317952
115negative regulation of Rho protein signal transduction (GO:0035024)2.70517964
116regulation of hair cycle (GO:0042634)2.70340845
117positive regulation of cAMP-mediated signaling (GO:0043950)2.68203699
118fatty-acyl-CoA biosynthetic process (GO:0046949)2.67734532
119skeletal muscle adaptation (GO:0043501)2.67650936
120positive regulation of fatty acid beta-oxidation (GO:0032000)2.66362773
121sterol biosynthetic process (GO:0016126)2.63611589
122negative regulation of mast cell activation (GO:0033004)2.63021163
123long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.62816400
124heparan sulfate proteoglycan metabolic process (GO:0030201)2.62290700
125protein-cofactor linkage (GO:0018065)2.62080486
126indolalkylamine metabolic process (GO:0006586)2.61206810
127auditory receptor cell stereocilium organization (GO:0060088)2.60797495
128spindle assembly involved in mitosis (GO:0090307)2.60551965
129thyroid hormone generation (GO:0006590)2.60057107
130cortical actin cytoskeleton organization (GO:0030866)2.60040595
131ribonucleoside bisphosphate metabolic process (GO:0033875)2.59331735
132nucleoside bisphosphate metabolic process (GO:0033865)2.59331735
133purine nucleoside bisphosphate metabolic process (GO:0034032)2.59331735
134negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.59310043
135endothelial cell proliferation (GO:0001935)2.59058464
136regulation of mesenchymal cell apoptotic process (GO:2001053)2.58770665
137limb bud formation (GO:0060174)2.58340943
138positive regulation of fatty acid oxidation (GO:0046321)2.57967132
139substantia nigra development (GO:0021762)2.57232522
140aspartate family amino acid catabolic process (GO:0009068)2.55982210
141positive regulation of vasculogenesis (GO:2001214)2.54410688
142protein palmitoylation (GO:0018345)2.54089787
143regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54070808
144regulation of establishment of cell polarity (GO:2000114)2.53232811
145skin development (GO:0043588)2.53193941
146negative regulation of axonogenesis (GO:0050771)2.51689404
147positive regulation of oligodendrocyte differentiation (GO:0048714)2.51170547
148response to redox state (GO:0051775)2.50453660
149presynaptic membrane organization (GO:0097090)2.50272458
150neuron remodeling (GO:0016322)2.50269357
151camera-type eye morphogenesis (GO:0048593)2.49378553
152peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.49163385
153organ growth (GO:0035265)2.47168688
154regulation of rhodopsin mediated signaling pathway (GO:0022400)2.47080065
155adult walking behavior (GO:0007628)2.46970920
156magnesium ion transport (GO:0015693)2.43027110
157rhodopsin mediated signaling pathway (GO:0016056)2.42792095
158Leydig cell differentiation (GO:0033327)2.39072168
159fatty-acyl-CoA metabolic process (GO:0035337)2.38128216
160interleukin-6-mediated signaling pathway (GO:0070102)2.37076340
161renal filtration (GO:0097205)2.36505285
162neuronal ion channel clustering (GO:0045161)2.36296235
163cortical cytoskeleton organization (GO:0030865)2.35611650
164peripheral nervous system development (GO:0007422)2.34288814
165cerebral cortex radially oriented cell migration (GO:0021799)2.32623334
166negative regulation of inclusion body assembly (GO:0090084)2.32464352
167negative regulation of JUN kinase activity (GO:0043508)2.30129472
168glomerular filtration (GO:0003094)2.30054419
169presynaptic membrane assembly (GO:0097105)2.29935663
170cellular response to epinephrine stimulus (GO:0071872)2.29837595
171potassium ion import (GO:0010107)2.29461013
172neuromuscular junction development (GO:0007528)2.28038038
173positive regulation of neurological system process (GO:0031646)2.24222259
174glycosylceramide metabolic process (GO:0006677)2.24124504
175transmission of nerve impulse (GO:0019226)2.21445652
176mesodermal cell differentiation (GO:0048333)2.21099647
177very long-chain fatty acid metabolic process (GO:0000038)2.21078592
178glycine transport (GO:0015816)2.20836717
179membrane raft organization (GO:0031579)2.20233344
180adhesion of symbiont to host (GO:0044406)2.17557020
181thioester biosynthetic process (GO:0035384)2.17181087
182acyl-CoA biosynthetic process (GO:0071616)2.17181087
183regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.17088792
184Golgi to plasma membrane protein transport (GO:0043001)2.16868942
185negative regulation of macroautophagy (GO:0016242)2.16804077
186regulation of voltage-gated calcium channel activity (GO:1901385)2.16369519
187negative regulation of axon extension (GO:0030517)2.16064517
188cellular response to monoamine stimulus (GO:0071868)2.16047433
189cellular response to catecholamine stimulus (GO:0071870)2.16047433
190positive regulation of glial cell differentiation (GO:0045687)2.14754391
191isoprenoid biosynthetic process (GO:0008299)2.14312909
192prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.13758687
193membrane protein ectodomain proteolysis (GO:0006509)2.12585413
194positive regulation of gliogenesis (GO:0014015)2.12181302
195positive regulation of actin filament depolymerization (GO:0030836)2.10964675
196response to epinephrine (GO:0071871)2.10795016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61653796
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12059959
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.06849021
4CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05587072
5ZNF274_21170338_ChIP-Seq_K562_Hela2.05460875
6* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.04325970
7* GBX2_23144817_ChIP-Seq_PC3_Human2.01280039
8AR_25329375_ChIP-Seq_VCAP_Human1.91947549
9EP300_21415370_ChIP-Seq_HL-1_Mouse1.89500305
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89158585
11IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86781129
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86113963
13EWS_26573619_Chip-Seq_HEK293_Human1.85748659
14SMAD_19615063_ChIP-ChIP_OVARY_Human1.85696685
15AR_21572438_ChIP-Seq_LNCaP_Human1.83897570
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82618020
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77376877
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75034035
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.73317342
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70694729
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67905694
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67905694
23FUS_26573619_Chip-Seq_HEK293_Human1.66388347
24IGF1R_20145208_ChIP-Seq_DFB_Human1.63775586
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62844607
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61120186
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59875337
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.59384168
29* DROSHA_22980978_ChIP-Seq_HELA_Human1.59032032
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58099368
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57708160
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.55661567
33P300_19829295_ChIP-Seq_ESCs_Human1.52959421
34CBP_20019798_ChIP-Seq_JUKART_Human1.51847715
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51847715
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48508563
37* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46417509
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46206738
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45995494
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43692182
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.42447841
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.42276509
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.41920760
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41813862
45EZH2_22144423_ChIP-Seq_EOC_Human1.41693886
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39346258
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38729031
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38729031
49AHR_22903824_ChIP-Seq_MCF-7_Human1.36948443
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.36943545
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.35271366
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34151239
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.32291542
54* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32286761
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31862285
56CDX2_22108803_ChIP-Seq_LS180_Human1.29900493
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27869896
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.27145323
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.26903098
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.26900202
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.26881418
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26752131
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25414022
64STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24609130
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24503012
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24235548
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23631370
68TP53_22573176_ChIP-Seq_HFKS_Human1.23247943
69OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23090647
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.23001878
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22889429
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21472380
73RUNX2_22187159_ChIP-Seq_PCA_Human1.20482544
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.20102802
75TP53_16413492_ChIP-PET_HCT116_Human1.19500342
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19101230
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18950487
78BCAT_22108803_ChIP-Seq_LS180_Human1.18949537
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18756745
80TAF15_26573619_Chip-Seq_HEK293_Human1.17604266
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17141923
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17123301
83* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16961681
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16836838
85AR_19668381_ChIP-Seq_PC3_Human1.16233272
86STAT3_23295773_ChIP-Seq_U87_Human1.15286636
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12687793
88WDR5_24793694_ChIP-Seq_LNCAP_Human1.12090831
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.11951132
90HOXB7_26014856_ChIP-Seq_BT474_Human1.11670078
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11669082
92* ER_23166858_ChIP-Seq_MCF-7_Human1.11318863
93* FOXA2_19822575_ChIP-Seq_HepG2_Human1.10892075
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10544331
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08756655
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07907283
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07505546
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07277508
99TCF4_22108803_ChIP-Seq_LS180_Human1.06972589
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06628690
101FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06417354
102ESR1_21235772_ChIP-Seq_MCF-7_Human1.06092898
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05650303
104* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05567465
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05316227
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04973332
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04673129
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04029566
109SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03705884
110RARB_27405468_Chip-Seq_BRAIN_Mouse1.03290021
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02999252
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01927443
113* CJUN_26792858_Chip-Seq_BT549_Human0.99901977
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99609543
115FOXA1_25329375_ChIP-Seq_VCAP_Human0.99381415
116FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99381415
117* SMAD4_21799915_ChIP-Seq_A2780_Human0.98345646
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97927017
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97816814
120TBX20_22328084_ChIP-Seq_HEART_Mouse0.97764918
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.97764918
122REST_21632747_ChIP-Seq_MESCs_Mouse0.97760460
123* PHF8_20622853_ChIP-Seq_HELA_Human0.97699742
124* TBL1_22424771_ChIP-Seq_293T_Human0.97427362
125* TCF4_23295773_ChIP-Seq_U87_Human0.96880000
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.96522189
127NANOG_18555785_Chip-Seq_ESCs_Mouse0.96160060
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.94527323
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.94190077
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92985040
131JUN_21703547_ChIP-Seq_K562_Human0.92699463
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92674164
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92627680
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92391493
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92389267
136VDR_22108803_ChIP-Seq_LS180_Human0.92388221
137TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92045206
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.91966310
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91835992
140TP53_18474530_ChIP-ChIP_U2OS_Human0.91615776
141SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.91263679
142ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91228381
143* GATA3_21878914_ChIP-Seq_MCF-7_Human0.90848426
144NFE2_27457419_Chip-Seq_LIVER_Mouse0.90812267
145* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90474902
146RING1B_27294783_Chip-Seq_NPCs_Mouse0.90008476
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89823085
148SOX2_21211035_ChIP-Seq_LN229_Gbm0.88109015
149GATA1_19941826_ChIP-Seq_K562_Human0.87500758
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87349739
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87213213
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.86961523
153CBX2_27304074_Chip-Seq_ESCs_Mouse0.86864617
154TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85950776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.85341875
2MP0003950_abnormal_plasma_membrane4.50307172
3MP0003183_abnormal_peptide_metabolism3.90044449
4MP0008875_abnormal_xenobiotic_pharmacok3.47003796
5MP0005670_abnormal_white_adipose3.24831436
6MP0005310_abnormal_salivary_gland3.15888213
7MP0002138_abnormal_hepatobiliary_system3.06925676
8MP0003690_abnormal_glial_cell2.96961085
9MP0005623_abnormal_meninges_morphology2.81992528
10MP0004885_abnormal_endolymph2.79433205
11MP0005551_abnormal_eye_electrophysiolog2.57624039
12MP0004270_analgesia2.46905558
13MP0003646_muscle_fatigue2.40799908
14MP0002876_abnormal_thyroid_physiology2.40611146
15MP0005171_absent_coat_pigmentation2.36648470
16MP0002254_reproductive_system_inflammat2.32790856
17MP0001984_abnormal_olfaction2.31831901
18MP0008438_abnormal_cutaneous_collagen2.25320557
19MP0003634_abnormal_glial_cell2.21467714
20MP0002139_abnormal_hepatobiliary_system2.17528775
21MP0010678_abnormal_skin_adnexa2.11342515
22MP0004742_abnormal_vestibular_system2.08931959
23MP0005410_abnormal_fertilization2.03227982
24MP0000383_abnormal_hair_follicle2.02449559
25MP0000569_abnormal_digit_pigmentation2.00974719
26MP0001299_abnormal_eye_distance/1.96707617
27MP0003880_abnormal_central_pattern1.96267412
28MP0001348_abnormal_lacrimal_gland1.90328789
29MP0001486_abnormal_startle_reflex1.87143438
30MP0000747_muscle_weakness1.86629221
31MP0003329_amyloid_beta_deposits1.84685454
32MP0002229_neurodegeneration1.84251887
33MP0004036_abnormal_muscle_relaxation1.82283182
34MP0004272_abnormal_basement_membrane1.81056215
35MP0005187_abnormal_penis_morphology1.75046798
36MP0000749_muscle_degeneration1.72252345
37MP0004145_abnormal_muscle_electrophysio1.71876940
38MP0001485_abnormal_pinna_reflex1.69393179
39MP0000751_myopathy1.69379214
40MP0000462_abnormal_digestive_system1.64450231
41MP0002272_abnormal_nervous_system1.64352084
42MP0004043_abnormal_pH_regulation1.62198206
43MP0005253_abnormal_eye_physiology1.60638438
44MP0004134_abnormal_chest_morphology1.57669394
45MP0006072_abnormal_retinal_apoptosis1.57666322
46MP0005647_abnormal_sex_gland1.54611076
47MP0003632_abnormal_nervous_system1.53153414
48MP0003011_delayed_dark_adaptation1.47735519
49MP0005389_reproductive_system_phenotype1.47380804
50MP0003136_yellow_coat_color1.45292296
51MP0009745_abnormal_behavioral_response1.44699986
52MP0000613_abnormal_salivary_gland1.43978417
53MP0001879_abnormal_lymphatic_vessel1.41685500
54MP0001919_abnormal_reproductive_system1.40441181
55MP0005195_abnormal_posterior_eye1.40204820
56MP0004130_abnormal_muscle_cell1.36734227
57MP0005377_hearing/vestibular/ear_phenot1.36517154
58MP0003878_abnormal_ear_physiology1.36517154
59MP0000778_abnormal_nervous_system1.36014846
60MP0002928_abnormal_bile_duct1.34877790
61MP0002269_muscular_atrophy1.33713598
62MP0004084_abnormal_cardiac_muscle1.31497639
63MP0000733_abnormal_muscle_development1.31027779
64MP0002064_seizures1.30795772
65MP0004185_abnormal_adipocyte_glucose1.30338139
66MP0001346_abnormal_lacrimal_gland1.30048367
67MP0002234_abnormal_pharynx_morphology1.28648306
68MP0003806_abnormal_nucleotide_metabolis1.28057128
69MP0009780_abnormal_chondrocyte_physiolo1.27073247
70MP0002108_abnormal_muscle_morphology1.24942949
71MP0000372_irregular_coat_pigmentation1.24103236
72MP0000230_abnormal_systemic_arterial1.23916363
73MP0003631_nervous_system_phenotype1.19807534
74MP0006276_abnormal_autonomic_nervous1.19345840
75MP0005646_abnormal_pituitary_gland1.19130093
76MP0004215_abnormal_myocardial_fiber1.17137932
77MP0003937_abnormal_limbs/digits/tail_de1.16839339
78MP0000762_abnormal_tongue_morphology1.15369034
79MP0003633_abnormal_nervous_system1.14423187
80MP0000427_abnormal_hair_cycle1.14209785
81MP0001661_extended_life_span1.13649239
82MP0004142_abnormal_muscle_tone1.13480315
83MP0004087_abnormal_muscle_fiber1.13257007
84MP0005167_abnormal_blood-brain_barrier1.13222795
85MP0004859_abnormal_synaptic_plasticity1.13218543
86MP0002160_abnormal_reproductive_system1.11514732
87MP0000631_abnormal_neuroendocrine_gland1.11048377
88MP0005409_darkened_coat_color1.10915819
89MP0002295_abnormal_pulmonary_circulatio1.10826325
90MP0002882_abnormal_neuron_morphology1.10564110
91MP0009384_cardiac_valve_regurgitation1.10424998
92MP0009046_muscle_twitch1.09872875
93MP0000537_abnormal_urethra_morphology1.07927574
94MP0003936_abnormal_reproductive_system1.07074970
95MP0008569_lethality_at_weaning1.06820368
96MP0001958_emphysema1.05358101
97MP0005503_abnormal_tendon_morphology1.04745910
98MP0008961_abnormal_basal_metabolism1.04737761
99MP0000003_abnormal_adipose_tissue1.04030512
100MP0002090_abnormal_vision1.03257537
101MP0003045_fibrosis1.01817310
102MP0002752_abnormal_somatic_nervous1.01486188
103MP0001968_abnormal_touch/_nociception1.00411387
104MP0000647_abnormal_sebaceous_gland0.99167022
105MP0002735_abnormal_chemical_nociception0.98756202
106MP0001177_atelectasis0.97757901
107MP0002970_abnormal_white_adipose0.97618297
108MP0005332_abnormal_amino_acid0.96643408
109MP0005620_abnormal_muscle_contractility0.96415393
110MP0009250_abnormal_appendicular_skeleto0.95044022
111MP0005330_cardiomyopathy0.94867769
112MP0004484_altered_response_of0.93999306
113MP0005375_adipose_tissue_phenotype0.93986904
114MP0000579_abnormal_nail_morphology0.93620572
115MP0005174_abnormal_tail_pigmentation0.93416849
116MP0002127_abnormal_cardiovascular_syste0.93264770
117MP0000955_abnormal_spinal_cord0.93161086
118MP0010329_abnormal_lipoprotein_level0.92563644
119MP0008872_abnormal_physiological_respon0.92191781
120MP0005085_abnormal_gallbladder_physiolo0.91566998
121MP0002938_white_spotting0.90960612
122MP0001963_abnormal_hearing_physiology0.90540190
123MP0003091_abnormal_cell_migration0.89671456
124MP0000566_synostosis0.89406406
125MP0003137_abnormal_impulse_conducting0.89139880
126MP0001905_abnormal_dopamine_level0.88499002
127MP0000759_abnormal_skeletal_muscle0.88023699
128MP0001501_abnormal_sleep_pattern0.87888711
129MP0000371_diluted_coat_color0.86916967
130MP0002572_abnormal_emotion/affect_behav0.86335807
131MP0005645_abnormal_hypothalamus_physiol0.84761204
132MP0003718_maternal_effect0.84540506
133MP0004858_abnormal_nervous_system0.83871079
134MP0005595_abnormal_vascular_smooth0.83867501
135MP0004233_abnormal_muscle_weight0.83599146
136MP0005391_vision/eye_phenotype0.83361058
137MP0008260_abnormal_autophagy0.82689917
138MP0002972_abnormal_cardiac_muscle0.82665535
139MP0002066_abnormal_motor_capabilities/c0.81772202
140MP0005369_muscle_phenotype0.81386126
141MP0000467_abnormal_esophagus_morphology0.81078306
142MP0002734_abnormal_mechanical_nocicepti0.81028638
143MP0005423_abnormal_somatic_nervous0.80217516
144MP0002075_abnormal_coat/hair_pigmentati0.78837936
145MP0005408_hypopigmentation0.77990139
146MP0000604_amyloidosis0.77598164
147MP0002133_abnormal_respiratory_system0.77330053
148MP0005388_respiratory_system_phenotype0.77330053
149MP0005451_abnormal_body_composition0.77038289
150MP0005666_abnormal_adipose_tissue0.76861220
151MP0003635_abnormal_synaptic_transmissio0.76763989
152MP0003385_abnormal_body_wall0.76361000
153MP0003638_abnormal_response/metabolism_0.76212456
154MP0001970_abnormal_pain_threshold0.76039528
155MP0001873_stomach_inflammation0.75803018
156MP0000639_abnormal_adrenal_gland0.75696567
157MP0003195_calcinosis0.75601345
158MP0001324_abnormal_eye_pigmentation0.73772885
159MP0004381_abnormal_hair_follicle0.73608135
160MP0005275_abnormal_skin_tensile0.72954244
161MP0004085_abnormal_heartbeat0.72721742
162MP0008775_abnormal_heart_ventricle0.72719425
163MP0002210_abnormal_sex_determination0.72221115
164MP0003698_abnormal_male_reproductive0.68796402
165MP0002736_abnormal_nociception_after0.68489934
166MP0005452_abnormal_adipose_tissue0.65994462

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.88227644
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.88227644
3Neurofibrillary tangles (HP:0002185)4.99180149
4Congenital sensorineural hearing impairment (HP:0008527)4.88557926
5Decreased circulating renin level (HP:0003351)4.68619937
6Abnormality of the corticospinal tract (HP:0002492)4.24654342
7Onion bulb formation (HP:0003383)4.22668180
8Termporal pattern (HP:0011008)4.03768611
9Insidious onset (HP:0003587)4.03768611
10True hermaphroditism (HP:0010459)3.95530124
11Sensory axonal neuropathy (HP:0003390)3.91514170
12Attenuation of retinal blood vessels (HP:0007843)3.83283152
13Pancreatic cysts (HP:0001737)3.81599376
14Peripheral hypomyelination (HP:0007182)3.76324943
15Cerebral inclusion bodies (HP:0100314)3.74129606
16Hyporeflexia of lower limbs (HP:0002600)3.54243618
17Bilateral sensorineural hearing impairment (HP:0008619)3.50833196
18Pancreatic fibrosis (HP:0100732)3.47233148
19Muscle fiber splitting (HP:0003555)3.41610793
20Abnormal pancreas size (HP:0012094)3.39532829
21Poikiloderma (HP:0001029)3.37280643
22Hyperkalemia (HP:0002153)3.28195828
23Lower limb hyperreflexia (HP:0002395)3.22628207
24Alacrima (HP:0000522)3.21983664
25Hyperventilation (HP:0002883)3.17976832
26Chronic hepatic failure (HP:0100626)3.16631705
27Abnormal drinking behavior (HP:0030082)3.09742730
28Polydipsia (HP:0001959)3.09742730
29Abnormal auditory evoked potentials (HP:0006958)3.09660627
30Supranuclear gaze palsy (HP:0000605)3.03770562
31Hypoplasia of the uterus (HP:0000013)2.99321056
32Intention tremor (HP:0002080)2.94490707
33Segmental peripheral demyelination/remyelination (HP:0003481)2.91191558
34Spastic gait (HP:0002064)2.90225831
35Tubular atrophy (HP:0000092)2.89549917
36Aplasia involving bones of the upper limbs (HP:0009823)2.75979639
37Aplasia of the phalanges of the hand (HP:0009802)2.75979639
38Aplasia involving bones of the extremities (HP:0009825)2.75979639
39Enlarged penis (HP:0000040)2.73284019
40Abnormality of midbrain morphology (HP:0002418)2.73268334
41Molar tooth sign on MRI (HP:0002419)2.73268334
42Abnormal biliary tract physiology (HP:0012439)2.72120377
43Bile duct proliferation (HP:0001408)2.72120377
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.71627607
45Parakeratosis (HP:0001036)2.64732973
46Cystic liver disease (HP:0006706)2.64706201
47Foot dorsiflexor weakness (HP:0009027)2.62943906
48Abolished electroretinogram (ERG) (HP:0000550)2.61905465
49Dysmetria (HP:0001310)2.58337890
50Difficulty running (HP:0009046)2.56148641
51Preaxial foot polydactyly (HP:0001841)2.54101702
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53061583
53Premature skin wrinkling (HP:0100678)2.52817055
54Male pseudohermaphroditism (HP:0000037)2.51297025
55Muscle hypertrophy of the lower extremities (HP:0008968)2.49188540
56Hypoplasia of the iris (HP:0007676)2.47976543
57Hyperglycinuria (HP:0003108)2.46994211
58Hammertoe (HP:0001765)2.45739341
59Coronal craniosynostosis (HP:0004440)2.45559264
60Decreased motor nerve conduction velocity (HP:0003431)2.42666423
61Pigmentary retinal degeneration (HP:0001146)2.42508830
62Abnormality of the foot musculature (HP:0001436)2.41106719
63Central scotoma (HP:0000603)2.39660831
64Cerebellar dysplasia (HP:0007033)2.39414038
65Bell-shaped thorax (HP:0001591)2.38623939
66Congenital stationary night blindness (HP:0007642)2.36428935
67Decreased lacrimation (HP:0000633)2.36100485
68Nephronophthisis (HP:0000090)2.36039798
69Stridor (HP:0010307)2.35702481
70Aplasia/hypoplasia of the uterus (HP:0008684)2.34620510
71Abnormality of renin-angiotensin system (HP:0000847)2.34224595
72Scanning speech (HP:0002168)2.33299943
73Unilateral renal agenesis (HP:0000122)2.31477613
74Action tremor (HP:0002345)2.29378937
75Premature rupture of membranes (HP:0001788)2.29257581
76Bicornuate uterus (HP:0000813)2.28565530
77Hypoplastic ischia (HP:0003175)2.27494391
78Gowers sign (HP:0003391)2.23783475
79Broad metatarsal (HP:0001783)2.23599736
80Hyperaldosteronism (HP:0000859)2.22465442
81Abnormality of the renal cortex (HP:0011035)2.22022079
82Amelogenesis imperfecta (HP:0000705)2.21571860
83Late onset (HP:0003584)2.21049668
84Slow saccadic eye movements (HP:0000514)2.20706821
85Infantile muscular hypotonia (HP:0008947)2.20079630
86Type II lissencephaly (HP:0007260)2.17826375
87Dyschromatopsia (HP:0007641)2.17539220
88Mesangial abnormality (HP:0001966)2.17498380
89Cerebral hypomyelination (HP:0006808)2.17009555
90Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16744407
91Ankle clonus (HP:0011448)2.15823151
92Clumsiness (HP:0002312)2.15580446
93Scapular winging (HP:0003691)2.11838272
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.11578630
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10394597
96Abnormality of alanine metabolism (HP:0010916)2.10394597
97Hyperalaninemia (HP:0003348)2.10394597
98Esophageal atresia (HP:0002032)2.10324671
99Axonal loss (HP:0003447)2.09997713
100Exercise-induced muscle cramps (HP:0003710)2.09842964
101Large for gestational age (HP:0001520)2.09676494
102Lower limb muscle weakness (HP:0007340)2.08616034
103Steppage gait (HP:0003376)2.07579642
104Abnormality of macular pigmentation (HP:0008002)2.07211893
105Chin dimple (HP:0010751)2.06977157
106Thickened helices (HP:0000391)2.06302411
107Abnormality of the phalanges of the 2nd finger (HP:0009541)2.05739723
108Keratoconus (HP:0000563)2.05649614
109Increased corneal curvature (HP:0100692)2.05649614
110Buphthalmos (HP:0000557)2.04359567
111Chorioretinal atrophy (HP:0000533)2.02310846
112Cone-rod dystrophy (HP:0000548)2.02282731
113Hypokalemic alkalosis (HP:0001949)2.02253254
114Abnormality of the ischium (HP:0003174)2.02012307
115Chronic bronchitis (HP:0004469)2.01866482
116Anteriorly placed anus (HP:0001545)2.01644980
117Abnormality of the renal medulla (HP:0100957)2.01511650
118Round ear (HP:0100830)2.00983681
119Calf muscle hypertrophy (HP:0008981)1.98709832
120Abnormal rod and cone electroretinograms (HP:0008323)1.98014391
121Choroideremia (HP:0001139)1.95982600
122Abnormality of potassium homeostasis (HP:0011042)1.95907629
123Keratoconjunctivitis (HP:0001096)1.95823953
124Scotoma (HP:0000575)1.95521690
125Stage 5 chronic kidney disease (HP:0003774)1.95210705
126Retrobulbar optic neuritis (HP:0100654)1.94796958
127Optic neuritis (HP:0100653)1.94796958
128Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.94612581
129Increased circulating renin level (HP:0000848)1.93762831
130Polyuria (HP:0000103)1.93420230
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.93157948
132Abnormality of the pericardium (HP:0001697)1.93080339
133Absent speech (HP:0001344)1.92367680
134Hyperactive renin-angiotensin system (HP:0000841)1.92312525
135Furrowed tongue (HP:0000221)1.91570192
136Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90587439
137Peripheral demyelination (HP:0011096)1.89938084
138EMG: myopathic abnormalities (HP:0003458)1.88374533
139Urinary urgency (HP:0000012)1.87803752
140Generalized hypopigmentation of hair (HP:0011358)1.86606498
141Gaze-evoked nystagmus (HP:0000640)1.85875023
142Hydroxyprolinuria (HP:0003080)1.85356200
143Abnormality of proline metabolism (HP:0010907)1.85356200
144Bony spicule pigmentary retinopathy (HP:0007737)1.84991779
145Shawl scrotum (HP:0000049)1.84181723
146Vitreoretinal degeneration (HP:0000655)1.84073514
147Gout (HP:0001997)1.83352010
148Occipital encephalocele (HP:0002085)1.81924664
149Focal segmental glomerulosclerosis (HP:0000097)1.81803579
150Germ cell neoplasia (HP:0100728)1.81206027
151Hypokalemia (HP:0002900)1.80909768
152Exercise-induced myalgia (HP:0003738)1.80557963
153Bulbous nose (HP:0000414)1.80513853
154Megalencephaly (HP:0001355)1.80239932
155Abnormality of the middle phalanges of the toes (HP:0010183)1.79902934
156Bundle branch block (HP:0011710)1.79509752
157Hypoplastic pelvis (HP:0008839)1.78409248
158Genetic anticipation (HP:0003743)1.77943673
159Metabolic alkalosis (HP:0200114)1.77496041
160Distal sensory impairment (HP:0002936)1.76659531
161Breast carcinoma (HP:0003002)1.75525617
162Turricephaly (HP:0000262)1.75338832
163Abnormality of dentin (HP:0010299)1.74848715
164Fair hair (HP:0002286)1.74276334
165Tachypnea (HP:0002789)1.74059956
166Frequent falls (HP:0002359)1.72729350
167Autoamputation (HP:0001218)1.72103632
168Abnormality of the calf musculature (HP:0001430)1.72090455
169Aplasia/Hypoplasia of the spleen (HP:0010451)1.72053291
170Absent septum pellucidum (HP:0001331)1.71675435
171Ulnar bowing (HP:0003031)1.71670572
172Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71185059
173Synostosis involving the elbow (HP:0003938)1.71097640
174Humeroradial synostosis (HP:0003041)1.71097640
175Heart block (HP:0012722)1.70843710
176Ketoacidosis (HP:0001993)1.70536637
177Abnormality of chloride homeostasis (HP:0011422)1.70436906
178Decreased central vision (HP:0007663)1.70028998
179Renovascular hypertension (HP:0100817)1.69381380
180Ulnar claw (HP:0001178)1.68216219
181Akinesia (HP:0002304)1.68139627
182Epiphyseal dysplasia (HP:0002656)1.67786820
183Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.67724590
184Retinal atrophy (HP:0001105)1.65638866
185Aplasia involving forearm bones (HP:0009822)1.64658033
186Absent forearm bone (HP:0003953)1.64658033
187Spastic paraplegia (HP:0001258)1.64129893
188Abnormality of glutamine family amino acid metabolism (HP:0010902)1.63939794
189Abnormality of the carotid arteries (HP:0005344)1.63234029
190Gonadotropin excess (HP:0000837)1.62269450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.80048942
2STK396.23513832
3WNK34.34633446
4EPHB13.91315523
5OXSR13.77536577
6PINK13.47189125
7WNK42.97331237
8BLK2.84149431
9MAPKAPK32.79751337
10FGFR22.78765228
11EEF2K2.76879328
12WNK12.75825583
13MET2.54148688
14PKN12.49098613
15ZAK2.32433895
16ICK2.31103507
17TXK1.93123751
18BCR1.89662072
19MAPKAPK51.87415056
20ADRBK21.85466975
21STK38L1.76764937
22PBK1.71775869
23NEK61.52585912
24ROCK21.47485220
25BMPR1B1.46210656
26PAK61.45805198
27LIMK11.44320332
28CDK121.41536363
29AKT31.39539738
30PNCK1.37795840
31PRKD31.37480439
32NTRK11.36667744
33SGK4941.34248697
34SGK2231.34248697
35UHMK11.34179229
36DMPK1.32782183
37CAMK1G1.29808852
38CSNK1A1L1.27002427
39TTN1.26609950
40CAMK2B1.25084274
41PAK31.23309465
42DDR21.21677560
43CAMK2D1.21373174
44PRKD11.20535441
45PIK3CA1.17440870
46PHKG21.13206121
47PHKG11.13206121
48NTRK31.12260127
49CLK11.11968305
50TYRO31.09118818
51FGR1.05347640
52MARK21.02879673
53MAP3K91.01059916
54OBSCN1.00810199
55TRPM71.00345671
56PDGFRB0.93664693
57BMX0.93361457
58CSNK1G30.90072095
59PRKCZ0.88875328
60GRK10.88079141
61PRKCH0.87310289
62CAMK2G0.87258222
63TNIK0.85453227
64TLK10.84803596
65INSRR0.84684829
66PRPF4B0.84035883
67CSNK1G10.83879079
68ACVR1B0.82991515
69PTK2B0.79328724
70PRKCQ0.78938685
71MAP4K20.77960703
72MST1R0.76816744
73ADRBK10.74723114
74SIK10.74525782
75PRKAA20.74383103
76PDPK10.73907764
77TAOK30.71603305
78MAPK130.71527339
79CSNK1G20.70739690
80IRAK10.69149757
81BRSK20.67530672
82CDK190.67436943
83PRKCE0.66489402
84YES10.66317270
85CAMK2A0.64232386
86MUSK0.62497261
87STK380.61767368
88GSK3A0.61437148
89LATS10.61126728
90CAMK10.60644258
91IRAK20.60583400
92PAK20.60421964
93EPHA20.59985634
94CAMK1D0.59788589
95TESK20.59462069
96CDK50.59266536
97ROCK10.59247016
98MST40.57191652
99CSNK1D0.56949668
100MAP3K20.56893818
101CHEK20.56569283
102PDGFRA0.56521799
103PDK20.56266312
104PRKD20.55672722
105FYN0.55433611
106LMTK20.54837211
107EIF2AK30.54785580
108PTK20.53088629
109MAP2K10.53086824
110MKNK20.52513339
111RPS6KB20.51746808
112PRKAA10.50963098
113STK240.50704290
114MAP3K70.50062949
115PRKG10.49598988
116MAPK150.48789720
117RET0.47767487
118STK110.47367033
119INSR0.46418250
120NEK10.46229427
121PDK10.46215670
122MAPK110.45162259
123HIPK20.44900302
124PRKACB0.43464976
125CDK140.43194877
126FGFR10.42137080
127MAPK70.42012722
128STK30.41341788
129SGK10.41268626
130SGK20.40974063
131PTK60.39085758
132FER0.38334863
133CSNK1A10.37043388
134RPS6KA30.36850814
135CDK150.36713062
136NME10.36174974
137MELK0.35922971
138MTOR0.35854621
139TIE10.35826042
140CDC42BPA0.35092856
141ALK0.34095698
142NEK20.34095558
143DAPK20.33236803
144RPS6KA20.32903484
145EPHA40.32393740
146PRKCA0.31561950
147CASK0.31450976
148CAMK40.31435889
149MAPK100.31195703
150IGF1R0.30938402
151NUAK10.30790121
152PRKACA0.30309093
153ERBB20.30131640
154PRKCI0.29988074
155MARK30.29379441
156RPS6KA50.29350975
157PRKCG0.28739984

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.67667187
2Selenocompound metabolism_Homo sapiens_hsa004503.51592098
3Nitrogen metabolism_Homo sapiens_hsa009103.13540295
4Steroid biosynthesis_Homo sapiens_hsa001003.06186862
5Fatty acid elongation_Homo sapiens_hsa000623.03040602
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.86851856
7Phototransduction_Homo sapiens_hsa047442.85491843
8Ether lipid metabolism_Homo sapiens_hsa005652.22838906
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08719233
10Tryptophan metabolism_Homo sapiens_hsa003801.99283968
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85081565
12Steroid hormone biosynthesis_Homo sapiens_hsa001401.84172771
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76899315
14Axon guidance_Homo sapiens_hsa043601.75844004
15ECM-receptor interaction_Homo sapiens_hsa045121.69387942
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67984119
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.67194730
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60551192
19Tight junction_Homo sapiens_hsa045301.59565240
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.57688081
21Nicotine addiction_Homo sapiens_hsa050331.56938686
22Fatty acid degradation_Homo sapiens_hsa000711.52752327
23Caffeine metabolism_Homo sapiens_hsa002321.52742131
24Arachidonic acid metabolism_Homo sapiens_hsa005901.49634720
25Sulfur metabolism_Homo sapiens_hsa009201.46649724
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.46571476
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.42482067
28Calcium signaling pathway_Homo sapiens_hsa040201.38693473
29Dilated cardiomyopathy_Homo sapiens_hsa054141.38130292
30Renal cell carcinoma_Homo sapiens_hsa052111.37537411
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35084890
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32432473
33Dorso-ventral axis formation_Homo sapiens_hsa043201.31502959
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28331859
35One carbon pool by folate_Homo sapiens_hsa006701.26167235
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21853805
37Sphingolipid metabolism_Homo sapiens_hsa006001.21731824
38Fat digestion and absorption_Homo sapiens_hsa049751.15824061
39Glycerolipid metabolism_Homo sapiens_hsa005611.13329222
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08627456
41Focal adhesion_Homo sapiens_hsa045101.06655373
42Fatty acid biosynthesis_Homo sapiens_hsa000611.04071666
43Histidine metabolism_Homo sapiens_hsa003401.03472795
44GABAergic synapse_Homo sapiens_hsa047271.02034074
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01419527
46Homologous recombination_Homo sapiens_hsa034401.01294692
47Glutamatergic synapse_Homo sapiens_hsa047241.01068012
48Fatty acid metabolism_Homo sapiens_hsa012120.97881619
49Fanconi anemia pathway_Homo sapiens_hsa034600.96991469
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95396261
51Butanoate metabolism_Homo sapiens_hsa006500.95265206
52Linoleic acid metabolism_Homo sapiens_hsa005910.94577166
53Endocytosis_Homo sapiens_hsa041440.94383789
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93498933
55Chemical carcinogenesis_Homo sapiens_hsa052040.93442921
56Retinol metabolism_Homo sapiens_hsa008300.93180151
57Vitamin B6 metabolism_Homo sapiens_hsa007500.92910939
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92749313
59Arginine biosynthesis_Homo sapiens_hsa002200.92147971
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.91360774
61Gastric acid secretion_Homo sapiens_hsa049710.91090570
62Pyruvate metabolism_Homo sapiens_hsa006200.90498488
63Propanoate metabolism_Homo sapiens_hsa006400.90276070
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.88796575
65Olfactory transduction_Homo sapiens_hsa047400.88552254
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86871319
67Arginine and proline metabolism_Homo sapiens_hsa003300.85441884
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84100188
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83675339
70Sulfur relay system_Homo sapiens_hsa041220.82882109
71Salivary secretion_Homo sapiens_hsa049700.82797574
72Vitamin digestion and absorption_Homo sapiens_hsa049770.80325933
73beta-Alanine metabolism_Homo sapiens_hsa004100.79242219
74Ras signaling pathway_Homo sapiens_hsa040140.79072892
75Hedgehog signaling pathway_Homo sapiens_hsa043400.78246669
76Peroxisome_Homo sapiens_hsa041460.77561432
77Taste transduction_Homo sapiens_hsa047420.77308505
78Long-term depression_Homo sapiens_hsa047300.77119843
79Cardiac muscle contraction_Homo sapiens_hsa042600.76216594
80Serotonergic synapse_Homo sapiens_hsa047260.74851437
81ErbB signaling pathway_Homo sapiens_hsa040120.73270397
82Renin secretion_Homo sapiens_hsa049240.73057161
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.72738994
84Morphine addiction_Homo sapiens_hsa050320.72351329
85Protein digestion and absorption_Homo sapiens_hsa049740.72318268
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72255320
87Circadian rhythm_Homo sapiens_hsa047100.71794568
88Mineral absorption_Homo sapiens_hsa049780.69867736
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69500857
90Proteoglycans in cancer_Homo sapiens_hsa052050.69214642
91Ovarian steroidogenesis_Homo sapiens_hsa049130.68302750
92Cocaine addiction_Homo sapiens_hsa050300.67847277
93Circadian entrainment_Homo sapiens_hsa047130.67547281
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67315896
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67027640
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66520100
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66470590
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65969613
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65220079
100Cholinergic synapse_Homo sapiens_hsa047250.65173090
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64733691
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64147285
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.63630663
104Hippo signaling pathway_Homo sapiens_hsa043900.63590337
105Pancreatic secretion_Homo sapiens_hsa049720.61537506
106Amoebiasis_Homo sapiens_hsa051460.61410809
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61242541
108ABC transporters_Homo sapiens_hsa020100.61099494
109N-Glycan biosynthesis_Homo sapiens_hsa005100.59970472
110cAMP signaling pathway_Homo sapiens_hsa040240.59392767
111Glucagon signaling pathway_Homo sapiens_hsa049220.58584311
112Gap junction_Homo sapiens_hsa045400.56717020
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55854250
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.55304478
115Tyrosine metabolism_Homo sapiens_hsa003500.54440092
116Oxytocin signaling pathway_Homo sapiens_hsa049210.54359316
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53375544
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52408784
119MAPK signaling pathway_Homo sapiens_hsa040100.52227125
120Metabolic pathways_Homo sapiens_hsa011000.52133140
121Choline metabolism in cancer_Homo sapiens_hsa052310.51764020
122Bile secretion_Homo sapiens_hsa049760.51652409
123Rap1 signaling pathway_Homo sapiens_hsa040150.51524556
124Inositol phosphate metabolism_Homo sapiens_hsa005620.51194992
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50490208
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50284296
127Basal transcription factors_Homo sapiens_hsa030220.50115212
128Dopaminergic synapse_Homo sapiens_hsa047280.48378661
129Lysosome_Homo sapiens_hsa041420.47941146
130Basal cell carcinoma_Homo sapiens_hsa052170.47427005
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46346152
132RNA polymerase_Homo sapiens_hsa030200.45170193
133Prostate cancer_Homo sapiens_hsa052150.42581366
134Thyroid hormone synthesis_Homo sapiens_hsa049180.42422968
135Glutathione metabolism_Homo sapiens_hsa004800.41846505
136Melanogenesis_Homo sapiens_hsa049160.41421105
137Wnt signaling pathway_Homo sapiens_hsa043100.40395653
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40250148
139Regulation of autophagy_Homo sapiens_hsa041400.39959026
140PPAR signaling pathway_Homo sapiens_hsa033200.39892620
141Vibrio cholerae infection_Homo sapiens_hsa051100.36847614
142Insulin secretion_Homo sapiens_hsa049110.36586643
143Adherens junction_Homo sapiens_hsa045200.36391217
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36361656
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35760182
146Lysine degradation_Homo sapiens_hsa003100.34724109
147Malaria_Homo sapiens_hsa051440.33919085

Most similar genes based on co-expression Upload to Enrichr

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