OTULIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.04705686
2nuclear pore organization (GO:0006999)5.04622837
3antigen processing and presentation of endogenous antigen (GO:0019883)4.81629836
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.58661452
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.58661452
6pore complex assembly (GO:0046931)4.55492017
7positive regulation of gamma-delta T cell activation (GO:0046645)3.78300903
8histone H3-K36 demethylation (GO:0070544)3.62872449
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.55749028
10regulation of RNA export from nucleus (GO:0046831)3.44599538
11ribosomal small subunit assembly (GO:0000028)3.36017374
12mitotic sister chromatid cohesion (GO:0007064)3.33705112
13cellular extravasation (GO:0045123)3.33054753
14monoubiquitinated protein deubiquitination (GO:0035520)3.29715158
15positive regulation of alpha-beta T cell proliferation (GO:0046641)3.28647969
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.26699428
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.26699428
18modulation by symbiont of host immune response (GO:0052553)3.26699428
19positive regulation by symbiont of host defense response (GO:0052509)3.26699428
20modulation by symbiont of host defense response (GO:0052031)3.26699428
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.26699428
22response to peptidoglycan (GO:0032494)3.24285368
23regulation of interleukin-12 biosynthetic process (GO:0045075)3.16309491
24B cell receptor signaling pathway (GO:0050853)3.15702874
25regulation of histone H3-K27 methylation (GO:0061085)3.14440748
26viral transcription (GO:0019083)3.12828817
27negative regulation of T cell mediated immunity (GO:0002710)3.12094302
28kynurenine metabolic process (GO:0070189)3.10715663
29L-phenylalanine metabolic process (GO:0006558)3.08056850
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.08056850
31regulation of gamma-delta T cell differentiation (GO:0045586)3.08035364
32aromatic amino acid family catabolic process (GO:0009074)3.07086989
33glycine metabolic process (GO:0006544)3.05990357
34indole-containing compound catabolic process (GO:0042436)3.05752064
35indolalkylamine catabolic process (GO:0046218)3.05752064
36tryptophan catabolic process (GO:0006569)3.05752064
37translational termination (GO:0006415)3.02481991
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.00735359
39L-phenylalanine catabolic process (GO:0006559)3.00735359
40response to muramyl dipeptide (GO:0032495)3.00071159
41positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.98082147
42regulation of nucleobase-containing compound transport (GO:0032239)2.95219055
43regulation of B cell receptor signaling pathway (GO:0050855)2.93400419
44urea cycle (GO:0000050)2.93216092
45urea metabolic process (GO:0019627)2.93216092
46positive regulation of B cell differentiation (GO:0045579)2.92934140
47NIK/NF-kappaB signaling (GO:0038061)2.92328526
48immunoglobulin mediated immune response (GO:0016064)2.91733696
49mitotic chromosome condensation (GO:0007076)2.91427879
50cellular response to ethanol (GO:0071361)2.91017366
51regulation of alpha-beta T cell proliferation (GO:0046640)2.88325176
52regulation of gamma-delta T cell activation (GO:0046643)2.87760520
53hepatocyte apoptotic process (GO:0097284)2.87109131
54tryptophan metabolic process (GO:0006568)2.85503563
55triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.84578735
56dosage compensation (GO:0007549)2.80883837
57embryonic process involved in female pregnancy (GO:0060136)2.80779970
58macrophage activation involved in immune response (GO:0002281)2.80312959
59positive thymic T cell selection (GO:0045059)2.79200561
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78799088
61folic acid-containing compound biosynthetic process (GO:0009396)2.77022454
62positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.75298492
63negative regulation of erythrocyte differentiation (GO:0045647)2.72684187
64imidazole-containing compound metabolic process (GO:0052803)2.69546470
65negative regulation of DNA repair (GO:0045738)2.69360665
66detection of molecule of bacterial origin (GO:0032490)2.68740401
67positive regulation of interleukin-2 production (GO:0032743)2.68447768
68protein carboxylation (GO:0018214)2.68272110
69peptidyl-glutamic acid carboxylation (GO:0017187)2.68272110
70regulation of B cell differentiation (GO:0045577)2.66806216
71translational elongation (GO:0006414)2.65736445
72positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.65474390
73negative regulation of interleukin-12 production (GO:0032695)2.65436066
74defense response to protozoan (GO:0042832)2.64748000
75nitrogen cycle metabolic process (GO:0071941)2.64637897
76negative thymic T cell selection (GO:0045060)2.64112049
77negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.63598024
78positive regulation of interferon-alpha production (GO:0032727)2.62346096
79negative T cell selection (GO:0043383)2.60461809
80germinal center formation (GO:0002467)2.60373584
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60322174
82positive regulation of interferon-beta production (GO:0032728)2.58418979
83interferon-gamma production (GO:0032609)2.55680314
84B cell mediated immunity (GO:0019724)2.55642726
85cysteine metabolic process (GO:0006534)2.54814513
86mitotic nuclear envelope disassembly (GO:0007077)2.54299686
87serine family amino acid biosynthetic process (GO:0009070)2.54098367
88complement activation, alternative pathway (GO:0006957)2.54041921
89T cell migration (GO:0072678)2.53612362
90regulation of response to interferon-gamma (GO:0060330)2.53211438
91positive regulation of granulocyte differentiation (GO:0030854)2.53129731
92protein targeting to ER (GO:0045047)2.52479921
93negative regulation of fibrinolysis (GO:0051918)2.52457683
94B cell proliferation (GO:0042100)2.52383936
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52004641
96response to protozoan (GO:0001562)2.51987402
97positive regulation of antigen processing and presentation (GO:0002579)2.51854781
98response to type I interferon (GO:0034340)2.51694665
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.51584818
100positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.50283072
101histone H3-K4 trimethylation (GO:0080182)2.49252157
102regulation of interferon-alpha production (GO:0032647)2.49080338
103cotranslational protein targeting to membrane (GO:0006613)2.48901672
104cellular response to type I interferon (GO:0071357)2.48828672
105type I interferon signaling pathway (GO:0060337)2.48828672
106antigen processing and presentation via MHC class Ib (GO:0002475)2.48259531
107nuclear envelope disassembly (GO:0051081)2.47631571
108membrane disassembly (GO:0030397)2.47631571
109regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.47602263
110DNA duplex unwinding (GO:0032508)2.46817957
111necroptotic process (GO:0070266)2.46044009
112phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.45945969
113histone H3-K9 demethylation (GO:0033169)2.45887733
114negative regulation of histone methylation (GO:0031061)2.45571985
115serine family amino acid catabolic process (GO:0009071)2.45562809
116fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.45539632
117natural killer cell mediated immunity (GO:0002228)2.45484344
118natural killer cell mediated cytotoxicity (GO:0042267)2.45484344
119positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.45364250
120response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.45219655
121response to host (GO:0075136)2.45219655
122response to host defenses (GO:0052200)2.45219655
123mature B cell differentiation (GO:0002335)2.45159715
124sulfur amino acid catabolic process (GO:0000098)2.44806586
125microglial cell activation (GO:0001774)2.44760244
126ribosomal small subunit biogenesis (GO:0042274)2.44691643
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.44304002
128tetrahydrofolate metabolic process (GO:0046653)2.43881957
129valine metabolic process (GO:0006573)2.43859399
130myeloid dendritic cell activation (GO:0001773)2.42230601
131response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.41794725
132response to host immune response (GO:0052572)2.41794725
133Arp2/3 complex-mediated actin nucleation (GO:0034314)2.41313522
134glyoxylate metabolic process (GO:0046487)2.41230722
135mature B cell differentiation involved in immune response (GO:0002313)2.41043507
136cellular response to zinc ion (GO:0071294)2.41009459
137regulation of interferon-beta biosynthetic process (GO:0045357)2.40873273
138serine family amino acid metabolic process (GO:0009069)2.40311266
139regulation of protein activation cascade (GO:2000257)2.39752727
140establishment of protein localization to endoplasmic reticulum (GO:0072599)2.39719240
141positive regulation of isotype switching (GO:0045830)2.39089807
142pre-miRNA processing (GO:0031054)2.38171491
143bile acid biosynthetic process (GO:0006699)2.37806650
144regulation of histone H3-K9 methylation (GO:0051570)2.37714135
145positive regulation of humoral immune response (GO:0002922)2.37414985
146protein localization to endoplasmic reticulum (GO:0070972)2.36813159
147nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.36633309
148positive regulation of DNA-templated transcription, initiation (GO:2000144)2.35734699
149programmed necrotic cell death (GO:0097300)2.35639290
150necrotic cell death (GO:0070265)2.35029129
151DNA geometric change (GO:0032392)2.34032583
152regulation of type I interferon-mediated signaling pathway (GO:0060338)2.33839439
153regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.33501255
154regulation of interleukin-2 production (GO:0032663)2.33466112
155complement activation, classical pathway (GO:0006958)2.33448221
156myeloid dendritic cell differentiation (GO:0043011)2.33359324
157B cell homeostasis (GO:0001782)2.31475443
158negative regulation of sterol transport (GO:0032372)2.31447383
159negative regulation of cholesterol transport (GO:0032375)2.31447383
160negative regulation of lymphocyte mediated immunity (GO:0002707)2.31222551
161pinocytosis (GO:0006907)2.30870444
162histone lysine demethylation (GO:0070076)2.30812119
163negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.30547272
164negative regulation of cell killing (GO:0031342)2.30547272
165lipopolysaccharide-mediated signaling pathway (GO:0031663)2.30141607
166regulation of interferon-beta production (GO:0032648)2.29901493
167ribosomal large subunit biogenesis (GO:0042273)2.29027449
168positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.28867340
169detection of other organism (GO:0098543)2.28787056
170DNA unwinding involved in DNA replication (GO:0006268)2.27742524
171T cell apoptotic process (GO:0070231)2.27545635
172negative regulation of fatty acid biosynthetic process (GO:0045717)2.27543347
173maturation of SSU-rRNA (GO:0030490)2.27463420
174viral life cycle (GO:0019058)2.27292079
175positive regulation of B cell mediated immunity (GO:0002714)2.26833834
176positive regulation of immunoglobulin mediated immune response (GO:0002891)2.26833834
177response to interleukin-15 (GO:0070672)2.26464446
178regulation of response to tumor cell (GO:0002834)2.26076916
179positive regulation of response to tumor cell (GO:0002836)2.26076916
180regulation of immune response to tumor cell (GO:0002837)2.26076916
181regulation of necroptotic process (GO:0060544)2.26017055
182positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.24931609
183histone demethylation (GO:0016577)2.24685376
184detection of external biotic stimulus (GO:0098581)2.24498484
185sister chromatid cohesion (GO:0007062)2.23985943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.50422238
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.08703366
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.02842168
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.77362590
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.74048456
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.61552666
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.61274767
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54668573
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.47201207
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.45660274
11MYC_22102868_ChIP-Seq_BL_Human2.36072974
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28720935
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.19379690
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17988011
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16229608
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14199048
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14171379
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.06821257
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06403913
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.01232630
21VDR_21846776_ChIP-Seq_THP-1_Human2.00042488
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99344609
23LXR_22158963_ChIP-Seq_LIVER_Mouse1.98060104
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95420424
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93033160
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.90002565
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82971421
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81976778
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81115356
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79948571
31MAF_26560356_Chip-Seq_TH1_Human1.76125413
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73925778
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72818925
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.72470345
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69626813
36SPI1_23547873_ChIP-Seq_NB4_Human1.63635464
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.62478506
38MYB_26560356_Chip-Seq_TH2_Human1.62072219
39SCL_19346495_ChIP-Seq_HPC-7_Human1.61703272
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61702854
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60894717
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59720871
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59207134
44MYB_26560356_Chip-Seq_TH1_Human1.58151863
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54267369
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53461547
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52443535
48GATA1_22025678_ChIP-Seq_K562_Human1.49918958
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45129430
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44324704
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42637949
52VDR_24763502_ChIP-Seq_THP-1_Human1.41551875
53UTX_26944678_Chip-Seq_JUKART_Human1.41132114
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.36188686
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35157095
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35086464
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34996902
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34785406
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34610803
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31160555
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30514474
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30423076
63SPI1_23127762_ChIP-Seq_K562_Human1.29071096
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28515082
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28320986
66TCF7_22412390_ChIP-Seq_EML_Mouse1.28296328
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27851181
68VDR_23849224_ChIP-Seq_CD4+_Human1.26311413
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.25639760
70MAF_26560356_Chip-Seq_TH2_Human1.24433418
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22781173
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20484067
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20196767
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20196401
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19556857
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19556857
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19255506
78MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17497244
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.17465854
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.17297558
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17268190
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16649264
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16100269
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15932517
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14862356
86TP63_17297297_ChIP-ChIP_HaCaT_Human1.13198630
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12828036
88RUNX_20019798_ChIP-Seq_JUKART_Human1.11779943
89DCP1A_22483619_ChIP-Seq_HELA_Human1.10534279
90EST1_17652178_ChIP-ChIP_JURKAT_Human1.09618339
91PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09058378
92FOXP3_21729870_ChIP-Seq_TREG_Human1.08969046
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08363930
94GATA3_27048872_Chip-Seq_THYMUS_Human1.07899974
95XRN2_22483619_ChIP-Seq_HELA_Human1.07866079
96AR_21909140_ChIP-Seq_LNCAP_Human1.06990079
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06974297
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.06815950
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05104630
100NCOR1_26117541_ChIP-Seq_K562_Human1.05092508
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03017560
102JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01228489
103KDM5A_27292631_Chip-Seq_BREAST_Human1.00854409
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00566245
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00469303
106CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00329267
107ELK3_25401928_ChIP-Seq_HUVEC_Human1.00121704
108PU_27001747_Chip-Seq_BMDM_Mouse0.99978685
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99869458
110ETS1_20019798_ChIP-Seq_JURKAT_Human0.99149999
111CIITA_25753668_ChIP-Seq_RAJI_Human0.98030619
112KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97572456
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97396805
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95809155
115CHD1_26751641_Chip-Seq_LNCaP_Human0.95652110
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95391885
117MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95014505
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94781170
119VDR_24787735_ChIP-Seq_THP-1_Human0.94396441
120FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93096822
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92266334
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92226690
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91649568
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91191501
125TFEB_21752829_ChIP-Seq_HELA_Human0.91008241
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90047570
127CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89626230
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89066108
129YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88957975
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87902859
131ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86915627
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85582005
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84439109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.41341761
2MP0002139_abnormal_hepatobiliary_system3.36666658
3MP0005360_urolithiasis3.03408570
4MP0000685_abnormal_immune_system2.80379155
5MP0002009_preneoplasia2.70509348
6MP0005671_abnormal_response_to2.51233570
7MP0005085_abnormal_gallbladder_physiolo2.45076232
8MP0001800_abnormal_humoral_immune2.37595831
9MP0005365_abnormal_bile_salt2.34489288
10MP0003436_decreased_susceptibility_to2.30282719
11MP0005387_immune_system_phenotype2.22475421
12MP0001790_abnormal_immune_system2.22475421
13MP0009785_altered_susceptibility_to2.17863854
14MP0009840_abnormal_foam_cell2.15308104
15MP0003303_peritoneal_inflammation2.13105390
16MP0005076_abnormal_cell_differentiation2.08883148
17MP0005000_abnormal_immune_tolerance2.04398323
18MP0005025_abnormal_response_to1.97838376
19MP0002452_abnormal_antigen_presenting1.97320581
20MP0003806_abnormal_nucleotide_metabolis1.94707548
21MP0002723_abnormal_immune_serum1.90935347
22MP0003300_gastrointestinal_ulcer1.90528353
23MP0001873_stomach_inflammation1.88066519
24MP0002138_abnormal_hepatobiliary_system1.86977200
25MP0003763_abnormal_thymus_physiology1.86231340
26MP0001853_heart_inflammation1.85656124
27MP0008875_abnormal_xenobiotic_pharmacok1.79315548
28MP0002396_abnormal_hematopoietic_system1.76156254
29MP0002420_abnormal_adaptive_immunity1.75409278
30MP0002254_reproductive_system_inflammat1.74269365
31MP0001819_abnormal_immune_cell1.73786361
32MP0002419_abnormal_innate_immunity1.71187753
33MP0002166_altered_tumor_susceptibility1.69617630
34MP0002398_abnormal_bone_marrow1.69614103
35MP0003191_abnormal_cellular_cholesterol1.69565835
36MP0009333_abnormal_splenocyte_physiolog1.69230459
37MP0005464_abnormal_platelet_physiology1.65884374
38MP0006082_CNS_inflammation1.64475334
39MP0010352_gastrointestinal_tract_polyps1.64231127
40MP0002148_abnormal_hypersensitivity_rea1.60652575
41MP0003252_abnormal_bile_duct1.58397156
42MP0010155_abnormal_intestine_physiology1.57146086
43MP0000716_abnormal_immune_system1.55925908
44MP0001845_abnormal_inflammatory_respons1.52939077
45MP0004510_myositis1.52036621
46MP0000689_abnormal_spleen_morphology1.51905388
47MP0002405_respiratory_system_inflammati1.51905311
48MP0000569_abnormal_digit_pigmentation1.47359143
49MP0000609_abnormal_liver_physiology1.47262868
50MP0008469_abnormal_protein_level1.46355944
51MP0004947_skin_inflammation1.45616855
52MP0002722_abnormal_immune_system1.45461474
53MP0010329_abnormal_lipoprotein_level1.41510514
54MP0002429_abnormal_blood_cell1.37971800
55MP0005083_abnormal_biliary_tract1.35399729
56MP0003091_abnormal_cell_migration1.33454434
57MP0008007_abnormal_cellular_replicative1.33103821
58MP0003693_abnormal_embryo_hatching1.32698817
59MP0004381_abnormal_hair_follicle1.30431111
60MP0003186_abnormal_redox_activity1.26658286
61MP0008260_abnormal_autophagy1.25461875
62MP0002006_tumorigenesis1.25222152
63MP0004233_abnormal_muscle_weight1.25157684
64MP0010307_abnormal_tumor_latency1.24536187
65MP0001545_abnormal_hematopoietic_system1.24171680
66MP0005397_hematopoietic_system_phenotyp1.24171680
67MP0000350_abnormal_cell_proliferation1.24142933
68MP0008057_abnormal_DNA_replication1.21001412
69MP0004808_abnormal_hematopoietic_stem1.17400739
70MP0005319_abnormal_enzyme/_coenzyme1.16257313
71MP0003566_abnormal_cell_adhesion1.15131189
72MP0003950_abnormal_plasma_membrane1.14731058
73MP0000465_gastrointestinal_hemorrhage1.14700730
74MP0003828_pulmonary_edema1.13911725
75MP0003195_calcinosis1.13639982
76MP0003724_increased_susceptibility_to1.11157661
77MP0003656_abnormal_erythrocyte_physiolo1.11122960
78MP0000490_abnormal_crypts_of1.10923356
79MP0000703_abnormal_thymus_morphology1.10805330
80MP0004185_abnormal_adipocyte_glucose1.08920640
81MP0009763_increased_sensitivity_to1.07200860
82MP0001666_abnormal_nutrient_absorption1.07099991
83MP0000598_abnormal_liver_morphology1.06753416
84MP0009764_decreased_sensitivity_to1.06199368
85MP0003705_abnormal_hypodermis_morpholog1.05478730
86MP0005621_abnormal_cell_physiology1.04648673
87MP0008058_abnormal_DNA_repair1.04012809
88MP0005332_abnormal_amino_acid1.02008126
89MP0001851_eye_inflammation1.01950293
90MP0000015_abnormal_ear_pigmentation1.01598464
91MP0001730_embryonic_growth_arrest0.99918302
92MP0003221_abnormal_cardiomyocyte_apopto0.99408794
93MP0000313_abnormal_cell_death0.98642876
94MP0003172_abnormal_lysosome_physiology0.97992693
95MP0000858_altered_metastatic_potential0.97643279
96MP0003786_premature_aging0.95863910
97MP0009697_abnormal_copulation0.95310249
98MP0009643_abnormal_urine_homeostasis0.95040206
99MP0003868_abnormal_feces_composition0.94638268
100MP0001661_extended_life_span0.94527735
101MP0003984_embryonic_growth_retardation0.93856247
102MP0002019_abnormal_tumor_incidence0.93489701
103MP0009278_abnormal_bone_marrow0.92127527
104MP0002088_abnormal_embryonic_growth/wei0.91943020
105MP0000371_diluted_coat_color0.91886180
106MP0005058_abnormal_lysosome_morphology0.91307731
107MP0001533_abnormal_skeleton_physiology0.90039762
108MP0003448_altered_tumor_morphology0.89539851
109MP0005451_abnormal_body_composition0.89430462
110MP0002086_abnormal_extraembryonic_tissu0.89178786
111MP0004957_abnormal_blastocyst_morpholog0.88460631
112MP0001764_abnormal_homeostasis0.87359991
113MP0005310_abnormal_salivary_gland0.86328645
114MP0002998_abnormal_bone_remodeling0.86300568
115MP0005380_embryogenesis_phenotype0.84772107
116MP0001672_abnormal_embryogenesis/_devel0.84772107
117MP0003077_abnormal_cell_cycle0.84396165
118MP0002933_joint_inflammation0.83758218
119MP0005584_abnormal_enzyme/coenzyme_acti0.83436003
120MP0009115_abnormal_fat_cell0.79313648
121MP0002118_abnormal_lipid_homeostasis0.78812925
122MP0005384_cellular_phenotype0.78099366
123MP0003453_abnormal_keratinocyte_physiol0.77556423
124MP0002877_abnormal_melanocyte_morpholog0.77091698
125MP0001216_abnormal_epidermal_layer0.76975259
126MP0009765_abnormal_xenobiotic_induced0.76930612
127MP0003866_abnormal_defecation0.76900708
128MP0005023_abnormal_wound_healing0.75531936
129MP0002136_abnormal_kidney_physiology0.75270618
130MP0010678_abnormal_skin_adnexa0.75236046
131MP0004019_abnormal_vitamin_homeostasis0.70978036
132MP0003111_abnormal_nucleus_morphology0.68074473
133MP0010094_abnormal_chromosome_stability0.67121527
134MP0010234_abnormal_vibrissa_follicle0.63733086
135MP0005166_decreased_susceptibility_to0.62182688

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)3.66881225
2Deep venous thrombosis (HP:0002625)3.62474330
3Eczematoid dermatitis (HP:0000976)3.56614706
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.53931468
5Recurrent gram-negative bacterial infections (HP:0005420)3.48943101
6Intrahepatic cholestasis (HP:0001406)3.36999074
7Recurrent bacterial skin infections (HP:0005406)3.35588779
8Thrombocytosis (HP:0001894)3.27119363
9Recurrent abscess formation (HP:0002722)3.19560015
10Hypobetalipoproteinemia (HP:0003563)3.17550760
11IgM deficiency (HP:0002850)3.16403620
12Viral hepatitis (HP:0006562)3.14374041
13Xanthomatosis (HP:0000991)3.11545597
14Elevated erythrocyte sedimentation rate (HP:0003565)3.10028546
15Prominent nose (HP:0000448)3.07541566
16Joint hemorrhage (HP:0005261)3.06680995
17Prolonged partial thromboplastin time (HP:0003645)3.01898237
18Recurrent fungal infections (HP:0002841)2.97046780
19Myocardial infarction (HP:0001658)2.95337934
20Gingival bleeding (HP:0000225)2.95023408
21Recurrent viral infections (HP:0004429)2.92872291
22Complement deficiency (HP:0004431)2.90210886
23Inflammation of the large intestine (HP:0002037)2.84408617
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84368571
25Recurrent skin infections (HP:0001581)2.83419396
26Optic neuritis (HP:0100653)2.82796100
27Retrobulbar optic neuritis (HP:0100654)2.82796100
28Abnormality of the common coagulation pathway (HP:0010990)2.80766962
29Colitis (HP:0002583)2.80459487
30Recurrent bronchitis (HP:0002837)2.80052967
31Recurrent cutaneous fungal infections (HP:0011370)2.76463140
32Chronic mucocutaneous candidiasis (HP:0002728)2.76463140
33Subacute progressive viral hepatitis (HP:0006572)2.75694981
34Gastrointestinal inflammation (HP:0004386)2.74492972
35Abnormality of the fingertips (HP:0001211)2.72974164
36Pustule (HP:0200039)2.70489616
37Chromsome breakage (HP:0040012)2.68365707
38Hyperlipoproteinemia (HP:0010980)2.67311484
39Orchitis (HP:0100796)2.66722215
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.66130306
41T lymphocytopenia (HP:0005403)2.62070125
42Abnormality of T cell number (HP:0011839)2.59316271
43Abnormality of pyrimidine metabolism (HP:0004353)2.57172740
44Deep philtrum (HP:0002002)2.55761603
45Abnormality of complement system (HP:0005339)2.55250820
46Abnormality of T cells (HP:0002843)2.54920623
47Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.54182426
48Gastrointestinal stroma tumor (HP:0100723)2.53782149
49Abnormality of T cell physiology (HP:0011840)2.52163644
50Vasculitis (HP:0002633)2.48897975
51Epistaxis (HP:0000421)2.48822568
52Mediastinal lymphadenopathy (HP:0100721)2.47532179
53Systemic lupus erythematosus (HP:0002725)2.45794303
54Slow saccadic eye movements (HP:0000514)2.44507881
55Chronic otitis media (HP:0000389)2.42768581
56Gastrointestinal infarctions (HP:0005244)2.42683697
57Epidermoid cyst (HP:0200040)2.42537280
58Agammaglobulinemia (HP:0004432)2.41758243
59Dysmetric saccades (HP:0000641)2.40231435
60Cellulitis (HP:0100658)2.40082934
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.38576592
62Hyperammonemia (HP:0001987)2.37120391
63Abnormality of cells of the erythroid lineage (HP:0012130)2.36931193
64Myositis (HP:0100614)2.36725494
65Meningitis (HP:0001287)2.35795963
66Fatigue (HP:0012378)2.35070383
67Nasal polyposis (HP:0100582)2.34795660
68Fair hair (HP:0002286)2.33752234
69Autoimmune hemolytic anemia (HP:0001890)2.31870096
70Increased IgE level (HP:0003212)2.31690090
71Panhypogammaglobulinemia (HP:0003139)2.29826265
72Hypolipoproteinemia (HP:0010981)2.28700858
73Acute myeloid leukemia (HP:0004808)2.28426463
74Impaired platelet aggregation (HP:0003540)2.26198900
75Abnormal platelet function (HP:0011869)2.26198900
76Chronic diarrhea (HP:0002028)2.25309088
77Abnormal number of erythroid precursors (HP:0012131)2.25089621
78Interstitial pulmonary disease (HP:0006530)2.22975339
79Abnormality of macrophages (HP:0004311)2.21999006
80Autoimmune thrombocytopenia (HP:0001973)2.21370848
81Increased serum ferritin (HP:0003281)2.20959627
82Abnormal platelet volume (HP:0011876)2.20937561
83Lymphopenia (HP:0001888)2.18402061
84Arterial thrombosis (HP:0004420)2.17867294
85Urticaria (HP:0001025)2.17546849
86Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.17127432
87Abnormality of iron homeostasis (HP:0011031)2.16746609
88Abnormality of cells of the lymphoid lineage (HP:0012140)2.16351553
89Osteolytic defects of the phalanges of the hand (HP:0009771)2.16022550
90Osteolytic defects of the hand bones (HP:0009699)2.16022550
91Spontaneous hematomas (HP:0007420)2.15348260
92Sandal gap (HP:0001852)2.14786916
93Recurrent sinusitis (HP:0011108)2.13944046
94Encephalitis (HP:0002383)2.13138981
95Petechiae (HP:0000967)2.12547424
96Keratoconjunctivitis sicca (HP:0001097)2.11630603
97Orthostatic hypotension (HP:0001278)2.11385973
98Chronic obstructive pulmonary disease (HP:0006510)2.11341798
99Obstructive lung disease (HP:0006536)2.11341798
100Abnormality of sulfur amino acid metabolism (HP:0004339)2.08430739
101Thrombophlebitis (HP:0004418)2.07998092
102Hypochromic anemia (HP:0001931)2.07580105
103Hepatocellular carcinoma (HP:0001402)2.06926482
104Basal cell carcinoma (HP:0002671)2.06163015
105Abnormality of the intrinsic pathway (HP:0010989)2.06031655
106Menorrhagia (HP:0000132)2.05463023
107Coarse hair (HP:0002208)2.04366660
108Abnormality of the nasal mucosa (HP:0000433)2.03270801
109IgG deficiency (HP:0004315)2.02747067
110Gingivitis (HP:0000230)2.02163297
111Joint swelling (HP:0001386)2.00813363
112Prolonged bleeding time (HP:0003010)2.00797965
113Abnormality of transition element cation homeostasis (HP:0011030)2.00372670
114IgA deficiency (HP:0002720)2.00115679
115Lymphoma (HP:0002665)1.99966082
116Heterotopia (HP:0002282)1.97967316
117Hepatitis (HP:0012115)1.96806172
118Ankyloglossia (HP:0010296)1.96726930
119Hypercholesterolemia (HP:0003124)1.96445728
120Hypoglycemic coma (HP:0001325)1.96036706
121Squamous cell carcinoma (HP:0002860)1.95379163
122Papilloma (HP:0012740)1.94014354
123Verrucae (HP:0200043)1.94014354
124Abnormality of methionine metabolism (HP:0010901)1.93607401
125Pulmonary embolism (HP:0002204)1.92742729
126Glomerulonephritis (HP:0000099)1.91758329
127Fat malabsorption (HP:0002630)1.91078021
128Increased mean platelet volume (HP:0011877)1.91007824
129Osteomyelitis (HP:0002754)1.90893197
130Hypoalphalipoproteinemia (HP:0003233)1.90249002
131Reticulocytopenia (HP:0001896)1.89796402
132Periodontitis (HP:0000704)1.89763635
133Aplasia/Hypoplasia of the thymus (HP:0010515)1.89544672
134Esophageal varix (HP:0002040)1.88942825
135Cutaneous melanoma (HP:0012056)1.86077152
136Abnormality of oral frenula (HP:0000190)1.85457969
137Dislocated radial head (HP:0003083)1.85057687
138Keratoconjunctivitis (HP:0001096)1.84376873
139Long eyelashes (HP:0000527)1.84258853
140Low anterior hairline (HP:0000294)1.81479099
141Neonatal hypoglycemia (HP:0001998)1.81339380
142Bladder carcinoma (HP:0002862)1.78807316
143Bladder neoplasm (HP:0009725)1.78807316
144Abnormality of chromosome stability (HP:0003220)1.77304980
145Generalized hypopigmentation of hair (HP:0011358)1.75085073
146Progressive external ophthalmoplegia (HP:0000590)1.75068030
147Granulocytopenia (HP:0001913)1.74618362
148Papillary thyroid carcinoma (HP:0002895)1.74440677
149Sparse lateral eyebrow (HP:0005338)1.74354788
150Persistence of primary teeth (HP:0006335)1.71421776
151Entropion (HP:0000621)1.71411571
152Short chin (HP:0000331)1.69972760
153Gangrene (HP:0100758)1.69534842
154Submucous cleft hard palate (HP:0000176)1.67946762
155Hemoptysis (HP:0002105)1.67476564
156Poikiloderma (HP:0001029)1.66333414
157Spinal cord lesions (HP:0100561)1.65727289
158Syringomyelia (HP:0003396)1.65727289
159Truncal obesity (HP:0001956)1.64690195
160Thoracolumbar scoliosis (HP:0002944)1.63180766
161Relative macrocephaly (HP:0004482)1.61903228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.25407700
2NME22.93494647
3PRPF4B2.70130808
4CAMK1D2.65629205
5MAP3K142.57922245
6TYK22.52596020
7TBK12.41919182
8ERN12.26614271
9JAK32.25526870
10CAMK1G2.13084257
11PKN22.08098987
12TRIB32.00193026
13IRAK31.94432543
14BCKDK1.87125667
15BLK1.83787138
16BMPR21.79653207
17FGFR41.78423317
18MAP3K101.77601308
19IRAK41.76058880
20ZAP701.74841060
21LRRK21.73676434
22GRK61.73439794
23STK101.70689693
24BTK1.70150726
25RPS6KA41.68800465
26KIT1.68750171
27MAP2K31.67359377
28IKBKB1.63606888
29FLT31.59396749
30TXK1.58187092
31BRD41.55859214
32CSF1R1.54121726
33IKBKE1.53817785
34SMG11.45931129
35JAK11.40581499
36TAOK31.37317868
37CAMKK21.35735022
38EEF2K1.32463092
39MELK1.32034898
40SYK1.30956436
41MAP3K111.24267806
42ITK1.23954704
43PDK21.23429432
44PIM11.21067144
45CSK1.20987269
46ICK1.19521747
47IRAK11.19328065
48PIM21.19149619
49TEC1.16412573
50SCYL21.11577774
51NEK21.09958340
52ACVR1B1.08177836
53CDK41.08109394
54CHUK1.06720613
55PTK61.04993886
56KDR1.00928972
57LCK1.00347384
58RIPK10.97359187
59YES10.97284797
60DYRK30.95305619
61JAK20.94394568
62MAP3K80.93192959
63MAP3K20.91088469
64MST40.90931713
65NEK90.90643803
66MST1R0.90554157
67HCK0.90510611
68SIK10.90267403
69EIF2AK30.90125499
70MAP3K30.89695125
71CDC70.88180350
72STK40.87704752
73EIF2AK10.86992389
74MTOR0.86237143
75LYN0.86234493
76TGFBR20.85503309
77TRPM70.85191340
78RPS6KB20.83479990
79TGFBR10.82067723
80AKT30.81235476
81SRPK10.80587410
82FGFR30.79204471
83RAF10.74412265
84TTN0.73861037
85WEE10.73601490
86KSR20.72711965
87PIK3CG0.72518196
88CDK60.72204224
89WNK10.72049270
90MAPK110.70690220
91PBK0.70132689
92CHEK10.69934447
93NEK60.67060012
94PDGFRB0.65247484
95TTK0.64672664
96RIPK40.64257816
97MARK30.61767199
98IRAK20.61731782
99NLK0.61288660
100BRSK20.60925257
101CHEK20.60573222
102TSSK60.60281608
103FGR0.59640318
104SGK30.59199493
105CDK120.57963413
106EPHB10.55244874
107MAP3K50.55087187
108STK240.54874545
109LATS10.53655879
110PRKCQ0.53411506
111CLK10.52691039
112FES0.51458662
113FRK0.51111339
114MAP3K130.50797487
115PDK10.49816770
116MAP3K60.48741412
117TLK10.48165249
118PRKAA20.46955961
119MAP3K70.46931352
120ABL20.46822528
121CDK70.46495277
122AURKB0.46226975
123MAPK40.42004104
124MAP2K60.41928879
125STK30.41643695
126ALK0.40332801
127EGFR0.38315634
128ABL10.36877694
129TESK20.36506477
130ATR0.35897070
131RPS6KA50.35848303
132TAOK20.35656301
133MAPKAPK20.35617851
134PASK0.34973394
135MAP3K10.32041342
136HIPK20.31811061
137TNK20.31105140

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09366290
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.67802168
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18823773
4Primary immunodeficiency_Homo sapiens_hsa053402.15197362
5Ribosome_Homo sapiens_hsa030102.07831779
6Staphylococcus aureus infection_Homo sapiens_hsa051502.04482335
7Non-small cell lung cancer_Homo sapiens_hsa052232.02070437
8Chronic myeloid leukemia_Homo sapiens_hsa052201.96850088
9Complement and coagulation cascades_Homo sapiens_hsa046101.88327653
10Antigen processing and presentation_Homo sapiens_hsa046121.85500632
11One carbon pool by folate_Homo sapiens_hsa006701.84949440
12Pancreatic cancer_Homo sapiens_hsa052121.77578571
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.73951922
14Selenocompound metabolism_Homo sapiens_hsa004501.72655988
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71563246
16Arginine biosynthesis_Homo sapiens_hsa002201.71103224
17DNA replication_Homo sapiens_hsa030301.70608376
18Leishmaniasis_Homo sapiens_hsa051401.66875391
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.65708742
20Caffeine metabolism_Homo sapiens_hsa002321.62067784
21Tryptophan metabolism_Homo sapiens_hsa003801.60718090
22Nitrogen metabolism_Homo sapiens_hsa009101.58487225
23Allograft rejection_Homo sapiens_hsa053301.51547790
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.49861722
25B cell receptor signaling pathway_Homo sapiens_hsa046621.48409830
26Small cell lung cancer_Homo sapiens_hsa052221.45226093
27Cell cycle_Homo sapiens_hsa041101.44782932
28Sulfur relay system_Homo sapiens_hsa041221.44547630
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41686455
30Fatty acid degradation_Homo sapiens_hsa000711.33938176
31Measles_Homo sapiens_hsa051621.33810791
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33472701
33Renal cell carcinoma_Homo sapiens_hsa052111.33051565
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31906912
35Graft-versus-host disease_Homo sapiens_hsa053321.30797780
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29673309
37Folate biosynthesis_Homo sapiens_hsa007901.29415939
38Prostate cancer_Homo sapiens_hsa052151.28236534
39Thyroid cancer_Homo sapiens_hsa052161.24716661
40Mismatch repair_Homo sapiens_hsa034301.20318089
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19302724
42Osteoclast differentiation_Homo sapiens_hsa043801.18813882
43Herpes simplex infection_Homo sapiens_hsa051681.17010210
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16232965
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15794189
46mTOR signaling pathway_Homo sapiens_hsa041501.12890918
47Asthma_Homo sapiens_hsa053101.12843110
48Autoimmune thyroid disease_Homo sapiens_hsa053201.12175023
49HTLV-I infection_Homo sapiens_hsa051661.11426624
50MicroRNAs in cancer_Homo sapiens_hsa052061.11232300
51Histidine metabolism_Homo sapiens_hsa003401.10320887
52FoxO signaling pathway_Homo sapiens_hsa040681.09430687
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09430006
54Hepatitis C_Homo sapiens_hsa051601.08208404
55Peroxisome_Homo sapiens_hsa041461.07997768
56Prolactin signaling pathway_Homo sapiens_hsa049171.07837545
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06809483
58Endometrial cancer_Homo sapiens_hsa052131.06716990
59Legionellosis_Homo sapiens_hsa051341.04984954
60Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04952297
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.04414273
62Colorectal cancer_Homo sapiens_hsa052101.02452140
63Base excision repair_Homo sapiens_hsa034101.01769792
64Hematopoietic cell lineage_Homo sapiens_hsa046400.99258528
65Bladder cancer_Homo sapiens_hsa052190.98740587
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98096726
67Non-homologous end-joining_Homo sapiens_hsa034500.97611526
68Phenylalanine metabolism_Homo sapiens_hsa003600.95516761
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94544863
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.93885158
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93834499
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.93660451
73VEGF signaling pathway_Homo sapiens_hsa043700.91906659
74Proteasome_Homo sapiens_hsa030500.91223522
75Pentose phosphate pathway_Homo sapiens_hsa000300.90644467
76beta-Alanine metabolism_Homo sapiens_hsa004100.88660942
77Chemical carcinogenesis_Homo sapiens_hsa052040.88337276
78RNA transport_Homo sapiens_hsa030130.88028250
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87960930
80PPAR signaling pathway_Homo sapiens_hsa033200.87757842
81Apoptosis_Homo sapiens_hsa042100.86264317
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85555533
83Systemic lupus erythematosus_Homo sapiens_hsa053220.85156978
84Chemokine signaling pathway_Homo sapiens_hsa040620.85043104
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84954970
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.84944772
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84642520
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84525006
89Platelet activation_Homo sapiens_hsa046110.84370723
90ErbB signaling pathway_Homo sapiens_hsa040120.83747036
91T cell receptor signaling pathway_Homo sapiens_hsa046600.80991348
92Influenza A_Homo sapiens_hsa051640.80684887
93Dorso-ventral axis formation_Homo sapiens_hsa043200.80579572
94mRNA surveillance pathway_Homo sapiens_hsa030150.79901732
95Biosynthesis of amino acids_Homo sapiens_hsa012300.79347683
96Toxoplasmosis_Homo sapiens_hsa051450.79268343
97Glioma_Homo sapiens_hsa052140.79011908
98Retinol metabolism_Homo sapiens_hsa008300.78763208
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77070667
100HIF-1 signaling pathway_Homo sapiens_hsa040660.76005912
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75819150
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75765378
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75710801
104Inositol phosphate metabolism_Homo sapiens_hsa005620.73934254
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73787151
106Pyrimidine metabolism_Homo sapiens_hsa002400.72782859
107Pertussis_Homo sapiens_hsa051330.72054954
108Fanconi anemia pathway_Homo sapiens_hsa034600.71021558
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70233920
110ABC transporters_Homo sapiens_hsa020100.70086500
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69847649
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.68656584
113Insulin resistance_Homo sapiens_hsa049310.68323447
114Proteoglycans in cancer_Homo sapiens_hsa052050.67954874
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.66886061
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66243997
117Tuberculosis_Homo sapiens_hsa051520.66236648
118Starch and sucrose metabolism_Homo sapiens_hsa005000.64848770
119Tyrosine metabolism_Homo sapiens_hsa003500.64350740
120Type I diabetes mellitus_Homo sapiens_hsa049400.64075215
121Malaria_Homo sapiens_hsa051440.63622615
122Acute myeloid leukemia_Homo sapiens_hsa052210.63592036
123TNF signaling pathway_Homo sapiens_hsa046680.62099429
124Choline metabolism in cancer_Homo sapiens_hsa052310.62093112
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61232277
126Carbon metabolism_Homo sapiens_hsa012000.60944397
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60675897
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60204616
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60057646
130p53 signaling pathway_Homo sapiens_hsa041150.59352883
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.58922390
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58880221
133Epstein-Barr virus infection_Homo sapiens_hsa051690.58024261
134Homologous recombination_Homo sapiens_hsa034400.56800632
135Hepatitis B_Homo sapiens_hsa051610.55010017
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.54528405
137Viral carcinogenesis_Homo sapiens_hsa052030.54321070
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53927220
139Sulfur metabolism_Homo sapiens_hsa009200.51614542
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51358406
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49486465
142Spliceosome_Homo sapiens_hsa030400.48474724
143Other glycan degradation_Homo sapiens_hsa005110.47580448
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46866642
145Nucleotide excision repair_Homo sapiens_hsa034200.46832113
146Lysine degradation_Homo sapiens_hsa003100.46613722
147Propanoate metabolism_Homo sapiens_hsa006400.45390104
148Fatty acid metabolism_Homo sapiens_hsa012120.44532538
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.43872083
150Shigellosis_Homo sapiens_hsa051310.43571130
151Viral myocarditis_Homo sapiens_hsa054160.43215617

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