OTX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of oligodendrocyte differentiation (GO:0048715)6.91912766
2paraxial mesoderm development (GO:0048339)5.72808558
3central nervous system myelination (GO:0022010)5.70250472
4axon ensheathment in central nervous system (GO:0032291)5.70250472
5negative regulation of astrocyte differentiation (GO:0048712)5.22506841
6negative regulation of glial cell differentiation (GO:0045686)5.18719591
7response to pheromone (GO:0019236)5.09299194
8respiratory tube development (GO:0030323)5.04531091
9viral transcription (GO:0019083)5.04031437
10lung-associated mesenchyme development (GO:0060484)4.97509641
11cell proliferation in forebrain (GO:0021846)4.91515979
12translational termination (GO:0006415)4.87056850
13epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.86903535
14heart valve formation (GO:0003188)4.64287410
15endocardial cushion morphogenesis (GO:0003203)4.64207541
16olfactory bulb development (GO:0021772)4.47786282
17neuronal stem cell maintenance (GO:0097150)4.45579459
18lateral sprouting from an epithelium (GO:0060601)4.43416015
19forebrain neuron differentiation (GO:0021879)4.34764501
20cartilage morphogenesis (GO:0060536)4.34144186
21Notch signaling involved in heart development (GO:0061314)4.30681330
22negative regulation of osteoblast proliferation (GO:0033689)4.27224192
23regulation of astrocyte differentiation (GO:0048710)4.26817264
24lung epithelium development (GO:0060428)4.22888601
25establishment of tissue polarity (GO:0007164)4.16052113
26establishment of planar polarity (GO:0001736)4.16052113
27tongue development (GO:0043586)4.14656549
28DNA ligation (GO:0006266)4.11001243
29axonal fasciculation (GO:0007413)4.06101825
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.01472635
31metanephric nephron tubule development (GO:0072234)4.01339628
32metanephric tubule development (GO:0072170)4.01339628
33cotranslational protein targeting to membrane (GO:0006613)4.00929572
34nonmotile primary cilium assembly (GO:0035058)3.99643018
35anatomical structure regression (GO:0060033)3.96728088
36positive regulation of gastrulation (GO:2000543)3.96510750
37epithelial cell fate commitment (GO:0072148)3.95725726
38protein targeting to ER (GO:0045047)3.93683329
39ribosomal small subunit assembly (GO:0000028)3.92406344
40generation of neurons (GO:0048699)3.89655156
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.87943097
42mesenchyme morphogenesis (GO:0072132)3.87393438
43limb bud formation (GO:0060174)3.85953842
44translational elongation (GO:0006414)3.85941475
45negative regulation of gliogenesis (GO:0014014)3.85478378
46lens fiber cell development (GO:0070307)3.85312680
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.80175980
48cellular protein complex disassembly (GO:0043624)3.80079665
49dentate gyrus development (GO:0021542)3.79557338
50neuron recognition (GO:0008038)3.78438373
51epithelial cilium movement (GO:0003351)3.78130268
52regulation of timing of cell differentiation (GO:0048505)3.74618002
53regulation of development, heterochronic (GO:0040034)3.73045386
54cerebral cortex neuron differentiation (GO:0021895)3.72340851
55viral life cycle (GO:0019058)3.69223815
56regulation of somitogenesis (GO:0014807)3.69049575
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.65083107
58retinal ganglion cell axon guidance (GO:0031290)3.64186750
59regulation of non-canonical Wnt signaling pathway (GO:2000050)3.63623034
60cerebral cortex radially oriented cell migration (GO:0021799)3.63348952
61protein localization to endoplasmic reticulum (GO:0070972)3.59829487
62regulation of oligodendrocyte differentiation (GO:0048713)3.58307538
63notochord development (GO:0030903)3.57871216
64lung morphogenesis (GO:0060425)3.56952533
65neuron fate determination (GO:0048664)3.55876874
66presynaptic membrane assembly (GO:0097105)3.55633822
67cilium movement (GO:0003341)3.54929655
68intraciliary transport (GO:0042073)3.54354657
69axonemal dynein complex assembly (GO:0070286)3.53785320
70microtubule depolymerization (GO:0007019)3.50614067
71G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.48784787
72metanephric nephron epithelium development (GO:0072243)3.45722896
73protein complex disassembly (GO:0043241)3.44275755
74maturation of SSU-rRNA (GO:0030490)3.43695640
75positive regulation of neuroblast proliferation (GO:0002052)3.43172092
76regulation of chemokine-mediated signaling pathway (GO:0070099)3.39702531
77motile cilium assembly (GO:0044458)3.38579599
78ribosomal small subunit biogenesis (GO:0042274)3.37498832
79negative regulation of smoothened signaling pathway (GO:0045879)3.37241338
80chromatin remodeling at centromere (GO:0031055)3.36740147
81mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.30659091
82kinetochore organization (GO:0051383)3.30557702
83cranial nerve morphogenesis (GO:0021602)3.30165139
84central nervous system projection neuron axonogenesis (GO:0021952)3.29755116
85ventricular trabecula myocardium morphogenesis (GO:0003222)3.29024397
86positive regulation of male gonad development (GO:2000020)3.28913749
87substrate-independent telencephalic tangential migration (GO:0021826)3.27781446
88substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.27781446
89heart trabecula morphogenesis (GO:0061384)3.27101021
90thalamus development (GO:0021794)3.25019494
91centriole replication (GO:0007099)3.24314944
92presynaptic membrane organization (GO:0097090)3.23491487
93left/right axis specification (GO:0070986)3.23469453
94spinal cord development (GO:0021510)3.21417309
95CENP-A containing nucleosome assembly (GO:0034080)3.20597639
96postsynaptic membrane organization (GO:0001941)3.20100882
97metanephric epithelium development (GO:0072207)3.17838048
98macromolecular complex disassembly (GO:0032984)3.16410820
99otic vesicle formation (GO:0030916)3.15483211
100regulation of male gonad development (GO:2000018)3.14139892
101glial cell proliferation (GO:0014009)3.13937376
102kidney morphogenesis (GO:0060993)3.11374242
103translational initiation (GO:0006413)3.08780222
104neuron fate commitment (GO:0048663)3.08160727
105regulation of glial cell differentiation (GO:0045685)3.06109864
106regulation of smoothened signaling pathway (GO:0008589)3.04456607
107cell surface receptor signaling pathway involved in heart development (GO:0061311)3.04396605
108planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02395649
109regulation of mesenchymal cell apoptotic process (GO:2001053)3.01216710
110positive regulation of neural precursor cell proliferation (GO:2000179)3.01009334
111dorsal/ventral neural tube patterning (GO:0021904)2.98437423
112telomere maintenance via semi-conservative replication (GO:0032201)2.96889798
113kinetochore assembly (GO:0051382)2.96383275
114* midbrain development (GO:0030901)2.94944695
115neural precursor cell proliferation (GO:0061351)2.94763486
116axon extension involved in axon guidance (GO:0048846)2.94512208
117neuron projection extension involved in neuron projection guidance (GO:1902284)2.94512208
118mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.93361662
119somite development (GO:0061053)2.91060903
120negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.89934109
121DNA topological change (GO:0006265)2.88604672
122layer formation in cerebral cortex (GO:0021819)2.87301070
123negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.86191371
124left/right pattern formation (GO:0060972)2.86112319
125cochlea morphogenesis (GO:0090103)2.84253962
126ovulation cycle (GO:0042698)2.83717765
127RNA localization (GO:0006403)2.81870530
128radial glial cell differentiation (GO:0060019)2.80836768
129negative regulation of Notch signaling pathway (GO:0045746)2.79070898
130hippocampus development (GO:0021766)2.78996592
131negative chemotaxis (GO:0050919)2.78323734
132DNA strand elongation involved in DNA replication (GO:0006271)2.77742414
133negative regulation of myoblast differentiation (GO:0045662)2.77091519
134spinal cord association neuron differentiation (GO:0021527)2.76735536
135regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75662298
136cornea development in camera-type eye (GO:0061303)2.74889242
137replication fork processing (GO:0031297)2.74793516
138dorsal/ventral pattern formation (GO:0009953)2.74374160
139collecting duct development (GO:0072044)2.72780978
140astrocyte differentiation (GO:0048708)2.72644345
141limb development (GO:0060173)2.71903810
142appendage development (GO:0048736)2.71903810
143telencephalon development (GO:0021537)2.71902217
144neuron fate specification (GO:0048665)2.71170789
145ATP synthesis coupled proton transport (GO:0015986)2.70892683
146energy coupled proton transport, down electrochemical gradient (GO:0015985)2.70892683
147smoothened signaling pathway (GO:0007224)2.70323109
148artery development (GO:0060840)2.70143118
149establishment of protein localization to mitochondrial membrane (GO:0090151)2.69883695
150protein targeting to membrane (GO:0006612)2.69398323
151DNA strand elongation (GO:0022616)2.68149060
152embryonic body morphogenesis (GO:0010172)2.67811380
153body morphogenesis (GO:0010171)2.67526791
154cilium assembly (GO:0042384)2.67390497
155nucleotide-excision repair, DNA gap filling (GO:0006297)2.67125581
156mitotic chromosome condensation (GO:0007076)2.66585056
157centriole assembly (GO:0098534)2.66433000
158negative regulation of transcription regulatory region DNA binding (GO:2000678)2.66201243
159negative regulation of epidermis development (GO:0045683)2.65153241
160cilium organization (GO:0044782)2.64366821
161negative regulation of chondrocyte differentiation (GO:0032331)2.63163770
162dendritic spine morphogenesis (GO:0060997)2.61458697
163inner ear receptor cell differentiation (GO:0060113)2.61231627
164auditory behavior (GO:0031223)2.61155902
165regulation of neuroblast proliferation (GO:1902692)2.60988555
166* inner ear morphogenesis (GO:0042472)2.60934199
167base-excision repair, AP site formation (GO:0006285)2.59948093
168gonadal mesoderm development (GO:0007506)2.59872220
169atrial cardiac muscle cell action potential (GO:0086014)2.58991016
170lens morphogenesis in camera-type eye (GO:0002089)2.58822660
171polyketide metabolic process (GO:0030638)2.58428855
172doxorubicin metabolic process (GO:0044598)2.58428855
173daunorubicin metabolic process (GO:0044597)2.58428855
174somatic stem cell division (GO:0048103)2.58423555
175nephron tubule development (GO:0072080)2.57582194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.13922969
2E2F7_22180533_ChIP-Seq_HELA_Human4.07468576
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.98348937
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.85651658
5* EZH2_27304074_Chip-Seq_ESCs_Mouse3.34266677
6* CBX2_27304074_Chip-Seq_ESCs_Mouse3.26254964
7* EED_16625203_ChIP-ChIP_MESCs_Mouse3.09911134
8GBX2_23144817_ChIP-Seq_PC3_Human2.94658936
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91901055
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83944940
11* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81364498
12* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.81288592
13* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78656981
14* RNF2_27304074_Chip-Seq_ESCs_Mouse2.77436425
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70540221
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.70300216
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70060615
18* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70060615
19* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58884725
20* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47317476
21* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.42386770
22* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38368072
23* TP63_19390658_ChIP-ChIP_HaCaT_Human2.33824698
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.29569426
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.25447333
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24682870
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16704719
28* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07743734
29* RNF2_27304074_Chip-Seq_NSC_Mouse2.04548644
30* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.02795350
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02199821
32AR_21572438_ChIP-Seq_LNCaP_Human1.96221015
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.90941627
34* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.89067841
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87994459
36ZNF274_21170338_ChIP-Seq_K562_Hela1.80609207
37* RING1B_27294783_Chip-Seq_ESCs_Mouse1.79617589
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75358107
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.75164108
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73772411
41FUS_26573619_Chip-Seq_HEK293_Human1.70480087
42* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69649758
43* RING1B_27294783_Chip-Seq_NPCs_Mouse1.69279229
44AR_21909140_ChIP-Seq_LNCAP_Human1.69119584
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66655647
46* TP53_20018659_ChIP-ChIP_R1E_Mouse1.66106230
47P300_19829295_ChIP-Seq_ESCs_Human1.65381438
48* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.61309010
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59896447
50CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58612385
51* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57399130
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.56895005
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.56765862
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.56602449
55DROSHA_22980978_ChIP-Seq_HELA_Human1.56213769
56MYC_18940864_ChIP-ChIP_HL60_Human1.55082976
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54740233
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52671465
59XRN2_22483619_ChIP-Seq_HELA_Human1.52271333
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.52171156
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49588269
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.46033536
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39975849
64* TTF2_22483619_ChIP-Seq_HELA_Human1.39694184
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36703065
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35960830
67REST_21632747_ChIP-Seq_MESCs_Mouse1.35263830
68* SOX2_16153702_ChIP-ChIP_HESCs_Human1.35058113
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34729586
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34456340
71* NANOG_16153702_ChIP-ChIP_HESCs_Human1.30984323
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30296749
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29260213
74KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28988538
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27784541
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27111114
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25547779
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25547779
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24602706
80TAF15_26573619_Chip-Seq_HEK293_Human1.23603998
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.23451637
82IGF1R_20145208_ChIP-Seq_DFB_Human1.21865054
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.20945794
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20879186
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18511041
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17311051
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16215299
88EWS_26573619_Chip-Seq_HEK293_Human1.16177886
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15385327
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.15116998
91AR_25329375_ChIP-Seq_VCAP_Human1.14943059
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14632441
93MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13679875
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13017161
95TP53_18474530_ChIP-ChIP_U2OS_Human1.12663101
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12184825
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10669138
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.08986431
99LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08427084
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08142802
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08102798
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06746106
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06264426
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06163112
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06126149
106GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05369275
107SOX9_26525672_Chip-Seq_HEART_Mouse1.04681317
108RXR_22108803_ChIP-Seq_LS180_Human1.03542416
109VDR_22108803_ChIP-Seq_LS180_Human1.03161687
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.02750278
111SMAD4_21799915_ChIP-Seq_A2780_Human1.02243509
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00348416
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00083763
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99571882
115* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99019409
116* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97912441
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97302666
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.96576357
119* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96342513
120IRF1_19129219_ChIP-ChIP_H3396_Human0.96160122
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95743334
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95630646
123P53_22387025_ChIP-Seq_ESCs_Mouse0.95594798
124ETS1_20019798_ChIP-Seq_JURKAT_Human0.94842979
125E2F1_18555785_Chip-Seq_ESCs_Mouse0.94710254
126* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93857323
127ELK1_19687146_ChIP-ChIP_HELA_Human0.93636064
128* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93499658
129AHR_22903824_ChIP-Seq_MCF-7_Human0.93481009
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92793735
131POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92444142
132SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92292523
133WDR5_24793694_ChIP-Seq_LNCAP_Human0.91702542
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.91110942
135* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89803537
136* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89339808
137RUNX2_22187159_ChIP-Seq_PCA_Human0.88916288
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88154033
139MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87947412
140MYC_19030024_ChIP-ChIP_MESCs_Mouse0.87445293
141* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87402128
142FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84795264
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84059313
144POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83831249
145E2F1_17053090_ChIP-ChIP_MCF-7_Human0.80086351
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78278106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.11385679
2MP0002653_abnormal_ependyma_morphology4.34573941
3MP0008789_abnormal_olfactory_epithelium4.30397677
4MP0009379_abnormal_foot_pigmentation4.24488490
5* MP0010030_abnormal_orbit_morphology4.02772649
6MP0006292_abnormal_olfactory_placode3.67009972
7MP0005394_taste/olfaction_phenotype3.64235567
8MP0005499_abnormal_olfactory_system3.64235567
9MP0005423_abnormal_somatic_nervous3.15006796
10* MP0000778_abnormal_nervous_system3.08770109
11MP0002249_abnormal_larynx_morphology2.77648931
12MP0000049_abnormal_middle_ear2.76664338
13MP0003880_abnormal_central_pattern2.71359064
14MP0002102_abnormal_ear_morphology2.14569836
15MP0001984_abnormal_olfaction2.12121401
16MP0000631_abnormal_neuroendocrine_gland2.02174451
17MP0002233_abnormal_nose_morphology1.87143705
18MP0003938_abnormal_ear_development1.84997366
19MP0008995_early_reproductive_senescence1.72931012
20MP0009780_abnormal_chondrocyte_physiolo1.68378115
21MP0002234_abnormal_pharynx_morphology1.66582847
22MP0005257_abnormal_intraocular_pressure1.66566565
23MP0001188_hyperpigmentation1.66542105
24MP0001529_abnormal_vocalization1.63182459
25MP0002751_abnormal_autonomic_nervous1.59059472
26MP0010094_abnormal_chromosome_stability1.53812781
27MP0000537_abnormal_urethra_morphology1.52794425
28MP0003937_abnormal_limbs/digits/tail_de1.50872662
29MP0003755_abnormal_palate_morphology1.49336281
30MP0003136_yellow_coat_color1.49222642
31MP0002282_abnormal_trachea_morphology1.46484778
32MP0005645_abnormal_hypothalamus_physiol1.42187749
33* MP0000026_abnormal_inner_ear1.40080216
34MP0000428_abnormal_craniofacial_morphol1.39345712
35MP0003115_abnormal_respiratory_system1.38142504
36MP0004381_abnormal_hair_follicle1.37822272
37* MP0003861_abnormal_nervous_system1.33819609
38* MP0005248_abnormal_Harderian_gland1.31089186
39MP0003693_abnormal_embryo_hatching1.29577782
40* MP0002116_abnormal_craniofacial_bone1.28887269
41MP0004885_abnormal_endolymph1.26490287
42MP0002638_abnormal_pupillary_reflex1.24386694
43MP0003942_abnormal_urinary_system1.20942942
44MP0002557_abnormal_social/conspecific_i1.19596421
45MP0003315_abnormal_perineum_morphology1.19479547
46MP0003121_genomic_imprinting1.19360030
47MP0000762_abnormal_tongue_morphology1.18977138
48MP0001286_abnormal_eye_development1.18218489
49MP0000955_abnormal_spinal_cord1.16869600
50MP0004134_abnormal_chest_morphology1.14726021
51MP0000647_abnormal_sebaceous_gland1.13567407
52MP0000383_abnormal_hair_follicle1.12018150
53MP0001324_abnormal_eye_pigmentation1.11063079
54MP0006276_abnormal_autonomic_nervous1.10707515
55* MP0005195_abnormal_posterior_eye1.09465700
56MP0003183_abnormal_peptide_metabolism1.09458668
57MP0005171_absent_coat_pigmentation1.08940011
58MP0001502_abnormal_circadian_rhythm1.08097209
59MP0002938_white_spotting1.06230128
60* MP0002152_abnormal_brain_morphology1.05160200
61MP0008057_abnormal_DNA_replication1.05047077
62MP0001293_anophthalmia1.03586249
63MP0009250_abnormal_appendicular_skeleto1.03528331
64MP0001486_abnormal_startle_reflex1.03510228
65MP0003122_maternal_imprinting1.03505644
66MP0008058_abnormal_DNA_repair1.02209546
67MP0001270_distended_abdomen1.01704028
68MP0000579_abnormal_nail_morphology1.01467350
69MP0004133_heterotaxia1.01355462
70MP0002184_abnormal_innervation1.00008749
71* MP0002882_abnormal_neuron_morphology0.95788921
72* MP0002752_abnormal_somatic_nervous0.95459321
73MP0003890_abnormal_embryonic-extraembry0.95088316
74MP0002089_abnormal_postnatal_growth/wei0.92642205
75MP0002098_abnormal_vibrissa_morphology0.91684863
76MP0002085_abnormal_embryonic_tissue0.91410967
77MP0003111_abnormal_nucleus_morphology0.88833029
78MP0008932_abnormal_embryonic_tissue0.88723917
79MP0003283_abnormal_digestive_organ0.88147740
80MP0005408_hypopigmentation0.87762193
81MP0000534_abnormal_ureter_morphology0.87572346
82MP0002932_abnormal_joint_morphology0.86324198
83MP0004859_abnormal_synaptic_plasticity0.86173955
84MP0002084_abnormal_developmental_patter0.85769284
85MP0003935_abnormal_craniofacial_develop0.85467918
86MP0002063_abnormal_learning/memory/cond0.84987806
87MP0001299_abnormal_eye_distance/0.84774204
88MP0002177_abnormal_outer_ear0.84597551
89MP0009053_abnormal_anal_canal0.84447353
90MP0006072_abnormal_retinal_apoptosis0.83675569
91MP0009278_abnormal_bone_marrow0.83385528
92MP0000613_abnormal_salivary_gland0.83017167
93MP0001485_abnormal_pinna_reflex0.82977012
94MP0002295_abnormal_pulmonary_circulatio0.80918659
95MP0009384_cardiac_valve_regurgitation0.80804949
96MP0002095_abnormal_skin_pigmentation0.79526368
97MP0005076_abnormal_cell_differentiation0.79361168
98MP0004742_abnormal_vestibular_system0.78671252
99MP0004811_abnormal_neuron_physiology0.78280521
100MP0005551_abnormal_eye_electrophysiolog0.77365302
101MP0008875_abnormal_xenobiotic_pharmacok0.77259221
102MP0004142_abnormal_muscle_tone0.77191184
103* MP0002210_abnormal_sex_determination0.77138823
104MP0002009_preneoplasia0.77104380
105MP0003635_abnormal_synaptic_transmissio0.76888805
106MP0005187_abnormal_penis_morphology0.75903549
107* MP0000163_abnormal_cartilage_morphology0.75300117
108* MP0005646_abnormal_pituitary_gland0.75265967
109* MP0002081_perinatal_lethality0.74585358
110* MP0002092_abnormal_eye_morphology0.73917935
111MP0002277_abnormal_respiratory_mucosa0.73147347
112MP0000432_abnormal_head_morphology0.72761140
113MP0002822_catalepsy0.72758162
114* MP0001346_abnormal_lacrimal_gland0.72345826
115MP0003119_abnormal_digestive_system0.69222204
116MP0003385_abnormal_body_wall0.69077298
117* MP0005391_vision/eye_phenotype0.68918382
118MP0002697_abnormal_eye_size0.68899743
119MP0003011_delayed_dark_adaptation0.68541569
120MP0003943_abnormal_hepatobiliary_system0.68232176
121MP0005377_hearing/vestibular/ear_phenot0.68149841
122MP0003878_abnormal_ear_physiology0.68149841
123MP0005508_abnormal_skeleton_morphology0.67605583
124MP0003936_abnormal_reproductive_system0.67024377
125MP0002111_abnormal_tail_morphology0.66723543
126MP0000678_abnormal_parathyroid_gland0.66094596
127MP0002572_abnormal_emotion/affect_behav0.64730611
128MP0001963_abnormal_hearing_physiology0.64608545
129* MP0000653_abnormal_sex_gland0.64035682
130MP0002109_abnormal_limb_morphology0.62747157

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)4.48359328
2Aplasia of the phalanges of the hand (HP:0009802)4.48359328
3Aplasia involving bones of the extremities (HP:0009825)4.48359328
4Megalencephaly (HP:0001355)4.22982403
5Abnormal number of incisors (HP:0011064)3.80954640
6Reticulocytopenia (HP:0001896)3.50070376
7Neonatal short-limb short stature (HP:0008921)3.49066843
8Split foot (HP:0001839)3.34233266
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.22377662
10Septo-optic dysplasia (HP:0100842)3.18245336
11Absent/shortened dynein arms (HP:0200106)3.17875955
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.17875955
13Abnormality of incisor morphology (HP:0011063)3.13191266
14Abnormality of the middle phalanges of the toes (HP:0010183)3.09251080
15Abnormal respiratory motile cilium morphology (HP:0005938)3.04438644
16Abnormal respiratory epithelium morphology (HP:0012253)3.04438644
17High anterior hairline (HP:0009890)3.03375265
18Abnormal respiratory motile cilium physiology (HP:0012261)3.00461036
19Abnormality of the incisor (HP:0000676)2.98238750
20Abnormality of the 4th metacarpal (HP:0010012)2.96439524
21Abnormality of cells of the erythroid lineage (HP:0012130)2.96248140
22Abnormality of cochlea (HP:0000375)2.92096353
23Pancreatic cysts (HP:0001737)2.92041351
24Partial duplication of thumb phalanx (HP:0009944)2.91851885
25True hermaphroditism (HP:0010459)2.90839186
26Oligodactyly (HP:0012165)2.83481821
27Coronal craniosynostosis (HP:0004440)2.82724120
28Abnormal sex determination (HP:0012244)2.78553873
29Sex reversal (HP:0012245)2.78553873
30Nephronophthisis (HP:0000090)2.77374985
31Preaxial hand polydactyly (HP:0001177)2.73688401
32Anencephaly (HP:0002323)2.72895510
33Fibular aplasia (HP:0002990)2.68798863
34Cystic liver disease (HP:0006706)2.68242533
35Morphological abnormality of the inner ear (HP:0011390)2.65377010
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.64360196
37Rhinitis (HP:0012384)2.63556958
38Bifid scrotum (HP:0000048)2.63548950
39Trigonocephaly (HP:0000243)2.62402807
40Abnormality of midbrain morphology (HP:0002418)2.62277702
41Molar tooth sign on MRI (HP:0002419)2.62277702
42Abnormal number of erythroid precursors (HP:0012131)2.58536672
43Abnormality of the intervertebral disk (HP:0005108)2.56619000
44Increased number of teeth (HP:0011069)2.55111552
45Sclerocornea (HP:0000647)2.54776563
46Duplication of thumb phalanx (HP:0009942)2.53181161
47Aplasia cutis congenita (HP:0001057)2.51091553
48Partial duplication of the phalanx of hand (HP:0009999)2.50234146
49Facial hemangioma (HP:0000329)2.50083593
50Hepatoblastoma (HP:0002884)2.49336783
51Adactyly (HP:0009776)2.48390942
52Ectopic kidney (HP:0000086)2.47660671
53Esophageal atresia (HP:0002032)2.46080088
5411 pairs of ribs (HP:0000878)2.44769131
55Oligodactyly (hands) (HP:0001180)2.41503843
56Triphalangeal thumb (HP:0001199)2.40301783
57Alacrima (HP:0000522)2.39410301
58Synostosis of carpal bones (HP:0005048)2.29521500
59Abnormality of the renal medulla (HP:0100957)2.27074488
60Abnormality of abdominal situs (HP:0011620)2.25335530
61Abdominal situs inversus (HP:0003363)2.25335530
62Nasolacrimal duct obstruction (HP:0000579)2.24343886
63Increased nuchal translucency (HP:0010880)2.22884652
64Broad hallux (HP:0010055)2.21835847
65Abnormality of the antihelix (HP:0009738)2.21097210
66Decreased central vision (HP:0007663)2.20493076
67Hemivertebrae (HP:0002937)2.19742633
68Preaxial foot polydactyly (HP:0001841)2.18748354
69Colon cancer (HP:0003003)2.18598188
70Anophthalmia (HP:0000528)2.17121877
71Postaxial hand polydactyly (HP:0001162)2.15982495
72Medial flaring of the eyebrow (HP:0010747)2.14787767
73Leiomyosarcoma (HP:0100243)2.14243535
74Uterine leiomyosarcoma (HP:0002891)2.14243535
75Macrocytic anemia (HP:0001972)2.13782969
76Conical tooth (HP:0000698)2.13774805
77Abnormality of the septum pellucidum (HP:0007375)2.12747121
78Optic nerve hypoplasia (HP:0000609)2.11471634
79Abnormality of the lacrimal duct (HP:0011481)2.11240833
80Adrenal hypoplasia (HP:0000835)2.11153640
81Overfolded helix (HP:0000396)2.08412044
82Maternal diabetes (HP:0009800)2.07406472
83Absent hand (HP:0004050)2.06544096
84Synostosis involving bones of the feet (HP:0009140)2.06449775
85Synostosis involving bones of the lower limbs (HP:0009138)2.06449775
86Absent forearm bone (HP:0003953)2.05664283
87Aplasia involving forearm bones (HP:0009822)2.05664283
88Decreased lacrimation (HP:0000633)2.05293798
89Mixed hearing impairment (HP:0000410)2.04665303
90Morphological abnormality of the middle ear (HP:0008609)2.03141620
91Bronchomalacia (HP:0002780)2.03103312
92Fibular hypoplasia (HP:0003038)2.02748672
93Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02345793
94Tarsal synostosis (HP:0008368)2.01488650
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01337616
96Broad thumb (HP:0011304)2.01116771
97Abnormality of the dental root (HP:0006486)2.00706204
98Taurodontia (HP:0000679)2.00706204
99Abnormality of permanent molar morphology (HP:0011071)2.00706204
100Rib fusion (HP:0000902)2.00569174
101Renal dysplasia (HP:0000110)1.99762757
102Recurrent corneal erosions (HP:0000495)1.99159249
103Cupped ear (HP:0000378)1.97467917
104Thickened helices (HP:0000391)1.96112444
105Congenital primary aphakia (HP:0007707)1.94434790
106Cutaneous finger syndactyly (HP:0010554)1.93401200
107Aplasia/Hypoplasia of the sternum (HP:0006714)1.93397248
108Abnormality of the dental pulp (HP:0006479)1.92481147
109Abnormality of the nasolacrimal system (HP:0000614)1.92183500
110Gait imbalance (HP:0002141)1.91758257
111Depressed nasal ridge (HP:0000457)1.90989440
112Broad toe (HP:0001837)1.90589885
113Sleep apnea (HP:0010535)1.90534803
114Absent radius (HP:0003974)1.89867168
115Hypoplasia of the fovea (HP:0007750)1.89261435
116Aplasia/Hypoplasia of the fovea (HP:0008060)1.89261435
117Irregular epiphyses (HP:0010582)1.88761037
118Vaginal atresia (HP:0000148)1.88190386
119Synostosis involving the elbow (HP:0003938)1.87333943
120Humeroradial synostosis (HP:0003041)1.87333943
121Abnormality of the aortic arch (HP:0012303)1.87332610
122Abnormality of molar morphology (HP:0011070)1.86775987
123Abnormality of molar (HP:0011077)1.86775987
124Male pseudohermaphroditism (HP:0000037)1.85620630
125Hypoplasia of the ulna (HP:0003022)1.85402848
126Broad alveolar ridges (HP:0000187)1.85352242
127Anomalous pulmonary venous return (HP:0010772)1.84634409
128Hypoplastic labia majora (HP:0000059)1.84564270
129Broad finger (HP:0001500)1.84286079
130Genital tract atresia (HP:0001827)1.83431441
131Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83405047
132Short 4th metacarpal (HP:0010044)1.83405047
133Broad phalanges of the hand (HP:0009768)1.82854172
134Abnormality of the right ventricle (HP:0001707)1.82823745
135Abnormal lung lobation (HP:0002101)1.81415498
136Absent septum pellucidum (HP:0001331)1.81405885
137Aplasia/Hypoplasia of the fibula (HP:0006492)1.81182646
138Polyphagia (HP:0002591)1.80855232
139Carpal synostosis (HP:0009702)1.80530944
140Pendular nystagmus (HP:0012043)1.78976852
141Stenosis of the external auditory canal (HP:0000402)1.78867069
142Poor coordination (HP:0002370)1.78541005
143Dandy-Walker malformation (HP:0001305)1.77914714
144Postaxial foot polydactyly (HP:0001830)1.77562114
145Down-sloping shoulders (HP:0200021)1.77467871
146Abnormality of the diencephalon (HP:0010662)1.77299390
147Transitional cell carcinoma of the bladder (HP:0006740)1.77021281
148Abnormally folded helix (HP:0008544)1.76806477
149Vitreoretinal degeneration (HP:0000655)1.76632435
150Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.75898420
151Broad distal phalanx of finger (HP:0009836)1.75520522
152Pancreatic fibrosis (HP:0100732)1.75396053
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75108788
154Absent epiphyses (HP:0010577)1.75108788
155Labial hypoplasia (HP:0000066)1.74142285
156Atelectasis (HP:0100750)1.74118743
157Growth hormone deficiency (HP:0000824)1.73934277
158Meckel diverticulum (HP:0002245)1.73230614
159Gastrointestinal atresia (HP:0002589)1.72833378
160Telecanthus (HP:0000506)1.72541979
161Aplasia/Hypoplasia of the ulna (HP:0006495)1.71967621
162Abnormality of the labia minora (HP:0012880)1.71953904
163Supernumerary ribs (HP:0005815)1.71889341
164Abnormality of the parietal bone (HP:0002696)1.71368892
165Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71112514
166Missing ribs (HP:0000921)1.70920264
167Holoprosencephaly (HP:0001360)1.70541726
168Renal hypoplasia (HP:0000089)1.70226878
169Stomach cancer (HP:0012126)1.69825158
170Chromsome breakage (HP:0040012)1.69721662
171Abnormal ciliary motility (HP:0012262)1.68611339
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.68269737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.44900560
2SIK33.28850714
3VRK23.00485247
4KSR12.99427178
5EPHA32.99009134
6BUB12.84487800
7CASK2.81233830
8BRD42.78001978
9WEE12.74269643
10CDK82.58561620
11PNCK2.53301271
12MAPK152.38733235
13NTRK22.36038427
14TNIK2.26978088
15SRPK12.16303709
16MAPK131.94001131
17PRKD31.92832400
18BRSK21.92116865
19BMPR1B1.91669742
20MARK11.83866901
21BCR1.80578281
22MKNK11.79939835
23ERBB31.79520292
24ZAK1.79041355
25EPHA41.76681877
26UHMK11.71610197
27ERBB21.63304776
28NEK21.59673123
29CDC71.54840313
30IRAK21.51817077
31PRPF4B1.51182785
32MKNK21.49594641
33PASK1.44479946
34NME11.43555021
35DYRK21.42905671
36AURKB1.41904907
37SGK2231.36385574
38SGK4941.36385574
39FGFR11.35768217
40CDK191.30262233
41MAP2K71.29028812
42SGK21.28899775
43CCNB11.27174488
44CAMK1G1.26472750
45TLK11.25840511
46ROCK21.21467192
47LATS11.17504918
48IRAK41.15984180
49MAP3K101.14846144
50BRSK11.13060996
51CDK31.11121422
52IRAK11.08132675
53PAK61.07762042
54DYRK1B1.07280701
55MAP3K41.07226821
56TYRO31.02456964
57CDK91.02197639
58PLK21.01026759
59MINK10.97441330
60ATR0.93626413
61ROCK10.93033005
62NEK60.91365542
63FGFR30.90302537
64RIPK10.85916978
65ICK0.85891196
66CDK180.85676419
67LMTK20.84667928
68LRRK20.82556703
69CAMK1D0.81322224
70MELK0.79773217
71EPHA20.77488236
72TRIM280.77420222
73NEK10.76331978
74TGFBR10.76077221
75NTRK30.73640746
76YES10.73332900
77STK38L0.72995673
78TAOK20.72299607
79STK160.71794652
80VRK10.70654446
81PKN10.70298080
82WNK40.70170815
83ATM0.68345195
84PRKCZ0.67678178
85AKT20.66968448
86CDK150.66073076
87SIK10.65904522
88PAK30.63783365
89AURKA0.63615769
90DYRK1A0.62683961
91NUAK10.62287396
92TTK0.62243848
93CDK140.60829714
94INSRR0.60266889
95CSNK1A1L0.58887207
96SGK30.58618759
97FGFR20.57818579
98CSNK1G20.57498403
99CDK11A0.57009710
100ILK0.55828938
101MAP4K20.55367699
102MUSK0.55118680
103CDK20.55099896
104MAPK90.54733088
105PRKCG0.54576826
106PHKG10.53696317
107PHKG20.53696317
108LATS20.53464599
109PLK10.52579281
110ERBB40.52262027
111PLK30.51431859
112CHEK20.51141792
113ADRBK10.50418301
114ACVR1B0.49130434
115EIF2AK20.48698165
116CSNK1G30.48384293
117CSNK1E0.47633576
118CSNK2A10.47543194
119PRKDC0.46663263
120STK30.46333381
121DMPK0.45801867
122STK110.44142287
123MAP3K120.43927701
124CHEK10.43380761
125RPS6KA10.42293794
126SGK10.42110873
127DYRK30.42043619
128CSNK2A20.42002012
129CDK50.41943585
130PRKCH0.41834158
131CAMK10.40261445
132NTRK10.39979477
133WNK30.39960995
134RPS6KB20.38674484
135CDK70.38117577
136MAP2K40.37500827
137CDK10.36334441
138PLK40.36317406
139TAF10.36104651
140TAOK10.31729221
141PKN20.31245975

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.41130634
2Basal cell carcinoma_Homo sapiens_hsa052174.35963707
3Notch signaling pathway_Homo sapiens_hsa043304.02541008
4Axon guidance_Homo sapiens_hsa043603.34364076
5Hedgehog signaling pathway_Homo sapiens_hsa043402.88424052
6* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.51640074
7Hippo signaling pathway_Homo sapiens_hsa043902.45118941
8Nicotine addiction_Homo sapiens_hsa050332.20030994
9Oxidative phosphorylation_Homo sapiens_hsa001902.12722368
10Wnt signaling pathway_Homo sapiens_hsa043102.11012568
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99287127
12Cell cycle_Homo sapiens_hsa041101.98562903
13Huntingtons disease_Homo sapiens_hsa050161.91239749
14Nucleotide excision repair_Homo sapiens_hsa034201.83676291
15Melanogenesis_Homo sapiens_hsa049161.83190827
16Spliceosome_Homo sapiens_hsa030401.81328111
17Parkinsons disease_Homo sapiens_hsa050121.78826091
18Circadian rhythm_Homo sapiens_hsa047101.76087262
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74791883
20Dorso-ventral axis formation_Homo sapiens_hsa043201.68252672
21mRNA surveillance pathway_Homo sapiens_hsa030151.67701680
22MicroRNAs in cancer_Homo sapiens_hsa052061.61630141
23RNA polymerase_Homo sapiens_hsa030201.55703125
24DNA replication_Homo sapiens_hsa030301.50181746
25Protein export_Homo sapiens_hsa030601.47883487
26Base excision repair_Homo sapiens_hsa034101.45468525
27Colorectal cancer_Homo sapiens_hsa052101.42875427
28Circadian entrainment_Homo sapiens_hsa047131.40743226
29Glutamatergic synapse_Homo sapiens_hsa047241.40410578
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37571600
31Nitrogen metabolism_Homo sapiens_hsa009101.29702026
32Fanconi anemia pathway_Homo sapiens_hsa034601.29243293
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26226269
34Salivary secretion_Homo sapiens_hsa049701.21072953
35TGF-beta signaling pathway_Homo sapiens_hsa043501.19805921
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19046205
37Olfactory transduction_Homo sapiens_hsa047401.18439085
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.15415344
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15115935
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14953825
41Steroid biosynthesis_Homo sapiens_hsa001001.14599648
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13970363
43Cardiac muscle contraction_Homo sapiens_hsa042601.12993045
44Fatty acid biosynthesis_Homo sapiens_hsa000611.07312315
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05291125
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05104621
47Alzheimers disease_Homo sapiens_hsa050101.04273253
48Homologous recombination_Homo sapiens_hsa034401.02353371
49One carbon pool by folate_Homo sapiens_hsa006701.00958465
50Basal transcription factors_Homo sapiens_hsa030220.99500864
51Endometrial cancer_Homo sapiens_hsa052130.99497515
52RNA transport_Homo sapiens_hsa030130.98630760
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97863342
54Melanoma_Homo sapiens_hsa052180.96483400
55Serotonergic synapse_Homo sapiens_hsa047260.96292603
56Butanoate metabolism_Homo sapiens_hsa006500.95972743
57Non-homologous end-joining_Homo sapiens_hsa034500.95492485
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95447317
59Gap junction_Homo sapiens_hsa045400.95152478
60RNA degradation_Homo sapiens_hsa030180.94592154
61Bladder cancer_Homo sapiens_hsa052190.92951656
62HTLV-I infection_Homo sapiens_hsa051660.92931737
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90925994
64Gastric acid secretion_Homo sapiens_hsa049710.90780718
65Morphine addiction_Homo sapiens_hsa050320.90587643
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89323586
67Cocaine addiction_Homo sapiens_hsa050300.88638357
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88211290
69ErbB signaling pathway_Homo sapiens_hsa040120.86783763
70GABAergic synapse_Homo sapiens_hsa047270.86558654
71Dopaminergic synapse_Homo sapiens_hsa047280.85386138
72Oocyte meiosis_Homo sapiens_hsa041140.84096496
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83490608
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82172970
75Insulin secretion_Homo sapiens_hsa049110.78259802
76Folate biosynthesis_Homo sapiens_hsa007900.76532216
77Pathways in cancer_Homo sapiens_hsa052000.76409420
78Cholinergic synapse_Homo sapiens_hsa047250.75580012
79Purine metabolism_Homo sapiens_hsa002300.73707061
80Amphetamine addiction_Homo sapiens_hsa050310.71752301
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70276215
82Mismatch repair_Homo sapiens_hsa034300.69965288
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69836078
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68673155
85Propanoate metabolism_Homo sapiens_hsa006400.68514607
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.65484157
87Phenylalanine metabolism_Homo sapiens_hsa003600.65038943
88Tyrosine metabolism_Homo sapiens_hsa003500.64958413
89Adherens junction_Homo sapiens_hsa045200.61331131
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59902502
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.59577425
92Taste transduction_Homo sapiens_hsa047420.59560828
93Pancreatic cancer_Homo sapiens_hsa052120.59147598
94Synaptic vesicle cycle_Homo sapiens_hsa047210.58723164
95Sulfur relay system_Homo sapiens_hsa041220.57138716
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56792192
97Pyruvate metabolism_Homo sapiens_hsa006200.54840860
98Glioma_Homo sapiens_hsa052140.54127117
99Alcoholism_Homo sapiens_hsa050340.53958730
100Ras signaling pathway_Homo sapiens_hsa040140.53866779
101Rap1 signaling pathway_Homo sapiens_hsa040150.53064678
102Proteasome_Homo sapiens_hsa030500.52352100
103cAMP signaling pathway_Homo sapiens_hsa040240.50915610
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50395141
105Arginine and proline metabolism_Homo sapiens_hsa003300.49621607
106Proteoglycans in cancer_Homo sapiens_hsa052050.49355970
107Biosynthesis of amino acids_Homo sapiens_hsa012300.48264846
108Peroxisome_Homo sapiens_hsa041460.48007544
109Prostate cancer_Homo sapiens_hsa052150.47460415
110Chemical carcinogenesis_Homo sapiens_hsa052040.47067444
111Phototransduction_Homo sapiens_hsa047440.46420595
112Fatty acid degradation_Homo sapiens_hsa000710.46404403
113Fatty acid metabolism_Homo sapiens_hsa012120.45916535
114Linoleic acid metabolism_Homo sapiens_hsa005910.44930140
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44923397
116Calcium signaling pathway_Homo sapiens_hsa040200.44814371
117p53 signaling pathway_Homo sapiens_hsa041150.44796124
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44486105
119Metabolic pathways_Homo sapiens_hsa011000.44065214
120Renal cell carcinoma_Homo sapiens_hsa052110.42793539
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42653227
122Tight junction_Homo sapiens_hsa045300.42245065
123Prolactin signaling pathway_Homo sapiens_hsa049170.40312221
124Non-small cell lung cancer_Homo sapiens_hsa052230.40203512
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40186803
126Lysine degradation_Homo sapiens_hsa003100.39312056
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38902706
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38735832
129Pyrimidine metabolism_Homo sapiens_hsa002400.38358640
130MAPK signaling pathway_Homo sapiens_hsa040100.37419058
131Glutathione metabolism_Homo sapiens_hsa004800.37246268
132GnRH signaling pathway_Homo sapiens_hsa049120.36813891
133Long-term depression_Homo sapiens_hsa047300.36725255
134Retinol metabolism_Homo sapiens_hsa008300.36577482
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36416209
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34815844
137Sulfur metabolism_Homo sapiens_hsa009200.34718990
138Choline metabolism in cancer_Homo sapiens_hsa052310.33268736
139Fat digestion and absorption_Homo sapiens_hsa049750.33230895
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33171089
141Fatty acid elongation_Homo sapiens_hsa000620.33159464
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30443331
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28108807
144Glycerolipid metabolism_Homo sapiens_hsa005610.25472468
145Histidine metabolism_Homo sapiens_hsa003400.23386258
146beta-Alanine metabolism_Homo sapiens_hsa004100.22099870
147Thyroid hormone synthesis_Homo sapiens_hsa049180.21054445
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20822688

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