OTX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)8.80359579
2detection of light stimulus involved in sensory perception (GO:0050962)8.07181822
3detection of light stimulus involved in visual perception (GO:0050908)8.07181822
4photoreceptor cell development (GO:0042461)7.55118281
5eye photoreceptor cell development (GO:0042462)7.34392832
6retinal cone cell development (GO:0046549)7.08047714
7photoreceptor cell maintenance (GO:0045494)6.71320236
8rhodopsin mediated signaling pathway (GO:0016056)5.77268516
9regulation of rhodopsin mediated signaling pathway (GO:0022400)5.54160185
10regulation of DNA methylation (GO:0044030)5.41347342
11neuron remodeling (GO:0016322)5.13186470
12negative regulation of cytosolic calcium ion concentration (GO:0051481)4.97374604
13retina development in camera-type eye (GO:0060041)4.90824310
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.87882663
15visual perception (GO:0007601)4.79785694
16chromatin remodeling at centromere (GO:0031055)4.77907908
17sensory perception of light stimulus (GO:0050953)4.76440348
18CENP-A containing nucleosome assembly (GO:0034080)4.72162418
19response to pheromone (GO:0019236)4.65143997
20GMP metabolic process (GO:0046037)4.62168839
21dopaminergic neuron differentiation (GO:0071542)4.61276985
22detection of light stimulus (GO:0009583)4.56585242
23peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.50524968
24regulation of meiosis I (GO:0060631)4.45210458
25protein localization to kinetochore (GO:0034501)4.31171585
26phototransduction (GO:0007602)4.25993291
27detection of visible light (GO:0009584)4.25250766
28centriole replication (GO:0007099)4.13161872
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.08599151
30dentate gyrus development (GO:0021542)4.06586888
31innervation (GO:0060384)4.01910126
32paraxial mesoderm development (GO:0048339)3.96994560
33histone exchange (GO:0043486)3.96353421
34mitotic metaphase plate congression (GO:0007080)3.92762623
35nonmotile primary cilium assembly (GO:0035058)3.88497796
36positive regulation of synapse maturation (GO:0090129)3.85452166
37meiotic cell cycle (GO:0051321)3.84894861
38cellular potassium ion homeostasis (GO:0030007)3.84542648
39DNA replication-independent nucleosome assembly (GO:0006336)3.80956975
40DNA replication-independent nucleosome organization (GO:0034724)3.80956975
41photoreceptor cell differentiation (GO:0046530)3.76411437
42eye photoreceptor cell differentiation (GO:0001754)3.76411437
43phototransduction, visible light (GO:0007603)3.74596990
44protein localization to chromosome, centromeric region (GO:0071459)3.72824451
45neuronal stem cell maintenance (GO:0097150)3.71773723
46regulation of histone H3-K9 methylation (GO:0051570)3.68906478
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.68144690
48metaphase plate congression (GO:0051310)3.62822607
49regulation of female gonad development (GO:2000194)3.47970799
50positive regulation of histone H3-K4 methylation (GO:0051571)3.47095055
51kinetochore organization (GO:0051383)3.44120951
52substrate-dependent cell migration (GO:0006929)3.43238095
53protein localization to synapse (GO:0035418)3.42795745
54potassium ion homeostasis (GO:0055075)3.38949642
55protein-chromophore linkage (GO:0018298)3.37575498
56mitotic chromosome condensation (GO:0007076)3.34431382
57piRNA metabolic process (GO:0034587)3.34030385
58cellular response to light stimulus (GO:0071482)3.32824545
59regulation of development, heterochronic (GO:0040034)3.32116588
60establishment of chromosome localization (GO:0051303)3.31151594
61kinetochore assembly (GO:0051382)3.29229484
62layer formation in cerebral cortex (GO:0021819)3.27636503
63regulation of mesoderm development (GO:2000380)3.27131369
64histone H3-K9 methylation (GO:0051567)3.23125157
65neuron maturation (GO:0042551)3.21181103
66regulation of acrosome reaction (GO:0060046)3.19022988
67regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18634247
68regulation of mitotic spindle checkpoint (GO:1903504)3.18634247
69positive regulation of dendritic spine morphogenesis (GO:0061003)3.18238334
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.15944063
71neuron development (GO:0048666)3.14970985
72detection of external stimulus (GO:0009581)3.14773799
73DNA replication-dependent nucleosome organization (GO:0034723)3.13693773
74DNA replication-dependent nucleosome assembly (GO:0006335)3.13693773
75detection of abiotic stimulus (GO:0009582)3.13062079
76viral transcription (GO:0019083)3.12396214
77sodium ion export (GO:0071436)3.09973365
78ribosomal small subunit assembly (GO:0000028)3.09596831
79translational termination (GO:0006415)3.09057924
80DNA replication checkpoint (GO:0000076)3.09025636
81synapsis (GO:0007129)3.07005899
82glycolytic process (GO:0006096)3.06017455
83synaptic vesicle exocytosis (GO:0016079)3.05910331
84positive regulation of neuroblast proliferation (GO:0002052)3.05894719
85regulation of short-term neuronal synaptic plasticity (GO:0048172)3.02735037
86protein localization to chromosome (GO:0034502)3.01242266
87mating behavior (GO:0007617)2.98910295
88regulation of secondary heart field cardioblast proliferation (GO:0003266)2.97688743
89regulation of cardioblast proliferation (GO:0003264)2.97688743
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.96849036
91female gamete generation (GO:0007292)2.95096211
92mitotic G2/M transition checkpoint (GO:0044818)2.93718051
93positive regulation of RNA splicing (GO:0033120)2.92214308
94epithelial cell fate commitment (GO:0072148)2.92195908
95synaptic vesicle maturation (GO:0016188)2.91193467
96neuroblast proliferation (GO:0007405)2.90381942
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90345983
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90345983
99positive regulation of mitotic sister chromatid separation (GO:1901970)2.90345983
100epithelial cilium movement (GO:0003351)2.89596079
101pyrimidine dimer repair (GO:0006290)2.85176314
102potassium ion export (GO:0071435)2.83542370
103regulation of chemokine-mediated signaling pathway (GO:0070099)2.82233628
104regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.81738888
105regulation of synapse maturation (GO:0090128)2.80888923
106striatum development (GO:0021756)2.80697421
107limb development (GO:0060173)2.79806515
108appendage development (GO:0048736)2.79806515
109negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.78563291
110histone H3-K9 modification (GO:0061647)2.78406468
111intraciliary transport (GO:0042073)2.78028074
112attachment of spindle microtubules to kinetochore (GO:0008608)2.77794805
113DNA methylation involved in gamete generation (GO:0043046)2.77320278
114positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.76017741
115negative regulation of reproductive process (GO:2000242)2.75118754
116positive regulation of chromosome segregation (GO:0051984)2.74469236
117positive regulation of cell cycle checkpoint (GO:1901978)2.74454485
118signal transduction involved in regulation of gene expression (GO:0023019)2.73235192
119chromatin assembly or disassembly (GO:0006333)2.73017152
120resolution of meiotic recombination intermediates (GO:0000712)2.72290648
121spindle checkpoint (GO:0031577)2.72104063
122retinal ganglion cell axon guidance (GO:0031290)2.71181297
123synaptic vesicle docking involved in exocytosis (GO:0016081)2.70867595
124regulation of double-strand break repair via homologous recombination (GO:0010569)2.70835645
125glucocorticoid biosynthetic process (GO:0006704)2.70322649
126synaptic vesicle endocytosis (GO:0048488)2.70063321
127ATP-dependent chromatin remodeling (GO:0043044)2.70053871
128C21-steroid hormone biosynthetic process (GO:0006700)2.69562007
129apical protein localization (GO:0045176)2.67052257
130regulation of non-canonical Wnt signaling pathway (GO:2000050)2.66735786
131lateral sprouting from an epithelium (GO:0060601)2.66173729
132endocardial cushion morphogenesis (GO:0003203)2.66051508
133oocyte development (GO:0048599)2.65010697
134cotranslational protein targeting to membrane (GO:0006613)2.64644129
135microtubule depolymerization (GO:0007019)2.64004215
136multicellular organism reproduction (GO:0032504)2.63294759
137SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.62929413
138centriole assembly (GO:0098534)2.62648608
139nucleosome disassembly (GO:0006337)2.62171274
140protein-DNA complex disassembly (GO:0032986)2.62171274
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.61448186
142regulation of mitotic metaphase/anaphase transition (GO:0030071)2.61448186
143negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61297255
144negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.61224625
145somite development (GO:0061053)2.60833703
146regulation of sister chromatid segregation (GO:0033045)2.60652068
147regulation of mitotic sister chromatid separation (GO:0010965)2.60652068
148regulation of mitotic sister chromatid segregation (GO:0033047)2.60652068
149peptidyl-arginine omega-N-methylation (GO:0035247)2.59736811
150regulation of transforming growth factor beta2 production (GO:0032909)2.59003706
151female gonad development (GO:0008585)2.58561400
152regulation of timing of cell differentiation (GO:0048505)2.58259554
153glandular epithelial cell differentiation (GO:0002067)2.57711697
154atrial cardiac muscle cell action potential (GO:0086014)2.57510531
155gene silencing by RNA (GO:0031047)2.56869322
156histone H2A acetylation (GO:0043968)2.56167676
157hypothalamus development (GO:0021854)2.55982022
158negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.55372317
159negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55372317
160negative regulation of mitotic sister chromatid separation (GO:2000816)2.55372317
161negative regulation of sister chromatid segregation (GO:0033046)2.55372317
162negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.55372317
163regulation of chromosome segregation (GO:0051983)2.54813772
164negative regulation of mitosis (GO:0045839)2.54346608
165regulation of spindle checkpoint (GO:0090231)2.53789971
166negative regulation of DNA-dependent DNA replication (GO:2000104)2.53424355
167protein targeting to ER (GO:0045047)2.52516126
168positive regulation of histone methylation (GO:0031062)2.52496667
169regulation of cell maturation (GO:1903429)2.52087878
170spermatid nucleus differentiation (GO:0007289)2.51945101
171negative regulation of chromosome segregation (GO:0051985)2.51813943
172male meiosis (GO:0007140)2.50890100
173positive regulation of transcription regulatory region DNA binding (GO:2000679)2.50738019
174positive regulation of neural precursor cell proliferation (GO:2000179)2.50309512
175mitotic sister chromatid segregation (GO:0000070)2.49673211
176positive regulation of TOR signaling (GO:0032008)2.49431660
177pre-miRNA processing (GO:0031054)2.49035292
178limb bud formation (GO:0060174)2.48688320
179regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.48335556
180mitotic spindle checkpoint (GO:0071174)2.48061748
181regulation of clathrin-mediated endocytosis (GO:2000369)2.47523556
182membrane hyperpolarization (GO:0060081)2.47513785
183histone H3-K4 trimethylation (GO:0080182)2.47307160
184negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.46479992
185negative regulation of translation, ncRNA-mediated (GO:0040033)2.46479992
186regulation of translation, ncRNA-mediated (GO:0045974)2.46479992
187regulation of gene silencing by miRNA (GO:0060964)2.46182287
188regulation of gene silencing by RNA (GO:0060966)2.46182287
189negative regulation of histone methylation (GO:0031061)2.45693378
190retina layer formation (GO:0010842)2.42230038
191regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.42051227
192embryonic foregut morphogenesis (GO:0048617)2.41770434
193embryonic retina morphogenesis in camera-type eye (GO:0060059)2.41184834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.45085841
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.66837419
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.96527409
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84217224
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.64018743
6CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.38560207
7ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.37502430
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35593933
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33657424
10* TP63_19390658_ChIP-ChIP_HaCaT_Human2.31919875
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.30769279
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.30668660
13* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20756549
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.15191415
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.12187477
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10754941
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.10719924
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09214458
19SOX2_18555785_ChIP-Seq_MESCs_Mouse2.02346285
20EWS_26573619_Chip-Seq_HEK293_Human2.00761820
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00173879
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.94057092
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89071605
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87861504
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.85415480
26OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.84125933
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.82267298
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78014833
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74768688
30ZNF274_21170338_ChIP-Seq_K562_Hela1.74633218
31* RING1B_27294783_Chip-Seq_NPCs_Mouse1.74096469
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71027966
33SOX2_16153702_ChIP-ChIP_HESCs_Human1.68362981
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67740780
35* P300_19829295_ChIP-Seq_ESCs_Human1.67340823
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67086232
37* EZH2_27304074_Chip-Seq_ESCs_Mouse1.66382433
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65055995
39REST_21632747_ChIP-Seq_MESCs_Mouse1.62228968
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60408962
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59424675
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.59371180
43TAF15_26573619_Chip-Seq_HEK293_Human1.56382686
44AR_21909140_ChIP-Seq_LNCAP_Human1.55075307
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54554755
46P53_22127205_ChIP-Seq_FIBROBLAST_Human1.53240551
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51319315
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.51312148
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51184378
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50718147
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50041370
52NANOG_21062744_ChIP-ChIP_HESCs_Human1.49377861
53IRF1_19129219_ChIP-ChIP_H3396_Human1.49189797
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48791880
55MYC_18940864_ChIP-ChIP_HL60_Human1.48329480
56* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48213494
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.48192885
58* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47247995
59* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46406293
60* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46206495
61ELK1_19687146_ChIP-ChIP_HELA_Human1.43903695
62* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.43724158
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43348884
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.42867506
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42784186
66* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42338926
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41452326
68SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.41429955
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40530114
70FUS_26573619_Chip-Seq_HEK293_Human1.39852828
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.39004082
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38839263
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38146362
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37096898
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36282220
76VDR_22108803_ChIP-Seq_LS180_Human1.36060688
77DROSHA_22980978_ChIP-Seq_HELA_Human1.35485285
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35417853
79* CBX2_27304074_Chip-Seq_ESCs_Mouse1.34379421
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.33205479
81* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31890295
82* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31288347
83* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31288347
84* SMAD3_21741376_ChIP-Seq_EPCs_Human1.30560073
85* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30255288
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29849642
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29268389
88* TP53_20018659_ChIP-ChIP_R1E_Mouse1.29099891
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27711358
90* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26657510
91JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25031361
92* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24686843
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24177496
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24029693
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21186352
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21155691
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20734702
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20314299
99CIITA_25753668_ChIP-Seq_RAJI_Human1.19716969
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19271732
101MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18710426
102IGF1R_20145208_ChIP-Seq_DFB_Human1.18643423
103* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18548439
104* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18312728
105SOX3_22085726_ChIP-Seq_NPCs_Mouse1.18033048
106* RNF2_27304074_Chip-Seq_NSC_Mouse1.16016348
107* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15918459
108* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15298248
109E2F7_22180533_ChIP-Seq_HELA_Human1.14456246
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14131411
111NANOG_16153702_ChIP-ChIP_HESCs_Human1.13867466
112XRN2_22483619_ChIP-Seq_HELA_Human1.13754037
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12669097
114* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12137248
115* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.10581672
116CTCF_27219007_Chip-Seq_Bcells_Human1.09043795
117GBX2_23144817_ChIP-Seq_PC3_Human1.08825714
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08818649
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08635206
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08635206
121GATA1_26923725_Chip-Seq_HPCs_Mouse1.07002758
122ISL1_27105846_Chip-Seq_CPCs_Mouse1.06807533
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05375135
124* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04181857
125SMAD4_21799915_ChIP-Seq_A2780_Human1.04016563
126CBP_20019798_ChIP-Seq_JUKART_Human1.03003524
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03003524
128* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02595470
129FLI1_27457419_Chip-Seq_LIVER_Mouse1.02491306
130POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.02157378
131NOTCH1_21737748_ChIP-Seq_TLL_Human1.01530025
132RARB_27405468_Chip-Seq_BRAIN_Mouse1.00992242
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00755949
134* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00662724
135* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00662724
136* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00662724
137ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00244058
138AR_25329375_ChIP-Seq_VCAP_Human1.00139022
139TTF2_22483619_ChIP-Seq_HELA_Human1.00070836
140MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99968717
141SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99096039
142* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98248914
143FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98105643
144STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98082374
145LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97888209
146* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97816643
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97547877
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97249752
149E2F1_21310950_ChIP-Seq_MCF-7_Human0.96887735
150RUNX2_22187159_ChIP-Seq_PCA_Human0.96262367
151FOXP3_21729870_ChIP-Seq_TREG_Human0.95514505
152* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94665408
153LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94149548
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93969050
155* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93843728
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93460289
157KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92283792
158EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90617747
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.89946304
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86994051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog6.62226845
2MP0006072_abnormal_retinal_apoptosis6.16020562
3MP0005253_abnormal_eye_physiology4.59113889
4MP0002653_abnormal_ependyma_morphology4.45297422
5MP0003718_maternal_effect3.88673342
6MP0003011_delayed_dark_adaptation3.85267961
7MP0003136_yellow_coat_color3.33003202
8* MP0005195_abnormal_posterior_eye3.26591611
9MP0002090_abnormal_vision2.69180455
10* MP0005391_vision/eye_phenotype2.67815254
11MP0001984_abnormal_olfaction2.60874394
12MP0009379_abnormal_foot_pigmentation2.59224921
13MP0001502_abnormal_circadian_rhythm2.58658185
14MP0000566_synostosis2.30082788
15MP0005248_abnormal_Harderian_gland2.21963093
16MP0003693_abnormal_embryo_hatching2.21385413
17* MP0001324_abnormal_eye_pigmentation2.13082465
18* MP0002752_abnormal_somatic_nervous2.02325132
19* MP0005394_taste/olfaction_phenotype1.98526189
20* MP0005499_abnormal_olfactory_system1.98526189
21* MP0008789_abnormal_olfactory_epithelium1.97239716
22MP0004133_heterotaxia1.96202042
23MP0000778_abnormal_nervous_system1.82972531
24MP0003950_abnormal_plasma_membrane1.80682636
25MP0002638_abnormal_pupillary_reflex1.80193037
26* MP0010030_abnormal_orbit_morphology1.80177962
27MP0003880_abnormal_central_pattern1.78753616
28MP0004885_abnormal_endolymph1.78531441
29MP0003283_abnormal_digestive_organ1.76283585
30MP0004233_abnormal_muscle_weight1.76226598
31MP0008057_abnormal_DNA_replication1.75037479
32MP0001346_abnormal_lacrimal_gland1.65475009
33MP0002229_neurodegeneration1.64728713
34* MP0006292_abnormal_olfactory_placode1.53025131
35* MP0001293_anophthalmia1.51663775
36* MP0002697_abnormal_eye_size1.47709624
37MP0002210_abnormal_sex_determination1.46031450
38MP0003567_abnormal_fetal_cardiomyocyte1.45326557
39* MP0002882_abnormal_neuron_morphology1.43704908
40* MP0003890_abnormal_embryonic-extraembry1.42492594
41MP0001929_abnormal_gametogenesis1.35954646
42* MP0001286_abnormal_eye_development1.35498093
43MP0004957_abnormal_blastocyst_morpholog1.34641938
44* MP0003861_abnormal_nervous_system1.33382872
45MP0000537_abnormal_urethra_morphology1.27422897
46MP0006276_abnormal_autonomic_nervous1.26980226
47MP0005395_other_phenotype1.26636342
48* MP0000631_abnormal_neuroendocrine_gland1.25551253
49MP0000653_abnormal_sex_gland1.21066864
50MP0002938_white_spotting1.19273285
51MP0003699_abnormal_female_reproductive1.14261371
52MP0005187_abnormal_penis_morphology1.13265930
53MP0002822_catalepsy1.10069845
54* MP0002751_abnormal_autonomic_nervous1.09981904
55MP0003941_abnormal_skin_development1.08249249
56MP0002127_abnormal_cardiovascular_syste1.07955388
57MP0001145_abnormal_male_reproductive1.07690561
58MP0009053_abnormal_anal_canal1.07678056
59MP0003937_abnormal_limbs/digits/tail_de1.07001147
60MP0002184_abnormal_innervation1.06282915
61MP0004142_abnormal_muscle_tone1.05004243
62MP0002102_abnormal_ear_morphology1.04987448
63MP0005220_abnormal_exocrine_pancreas1.04133177
64MP0000372_irregular_coat_pigmentation1.03975135
65MP0000569_abnormal_digit_pigmentation1.03852570
66MP0002111_abnormal_tail_morphology1.03182383
67MP0008995_early_reproductive_senescence1.02129519
68MP0004782_abnormal_surfactant_physiolog1.00485532
69MP0005423_abnormal_somatic_nervous1.00142785
70MP0005377_hearing/vestibular/ear_phenot0.99009836
71MP0003878_abnormal_ear_physiology0.99009836
72* MP0002152_abnormal_brain_morphology0.98584626
73MP0001485_abnormal_pinna_reflex0.98038628
74* MP0002085_abnormal_embryonic_tissue0.97231442
75MP0001119_abnormal_female_reproductive0.96977974
76* MP0002161_abnormal_fertility/fecundity0.96710349
77MP0000026_abnormal_inner_ear0.96077185
78* MP0005380_embryogenesis_phenotype0.94845183
79* MP0001672_abnormal_embryogenesis/_devel0.94845183
80* MP0000049_abnormal_middle_ear0.94418148
81MP0000534_abnormal_ureter_morphology0.93567715
82MP0003698_abnormal_male_reproductive0.92509531
83MP0002084_abnormal_developmental_patter0.92272432
84MP0000647_abnormal_sebaceous_gland0.91141891
85MP0002160_abnormal_reproductive_system0.89888174
86* MP0003119_abnormal_digestive_system0.89743002
87MP0001299_abnormal_eye_distance/0.89105909
88MP0008058_abnormal_DNA_repair0.88980396
89MP0008007_abnormal_cellular_replicative0.86522418
90MP0003938_abnormal_ear_development0.86137302
91MP0001730_embryonic_growth_arrest0.85957975
92* MP0002233_abnormal_nose_morphology0.85367561
93* MP0003935_abnormal_craniofacial_develop0.84937961
94MP0008877_abnormal_DNA_methylation0.84088045
95MP0000579_abnormal_nail_morphology0.83096874
96MP0001486_abnormal_startle_reflex0.82938780
97MP0003111_abnormal_nucleus_morphology0.81612530
98MP0003115_abnormal_respiratory_system0.80410137
99MP0001529_abnormal_vocalization0.80107734
100MP0003121_genomic_imprinting0.80010410
101MP0005646_abnormal_pituitary_gland0.79223831
102MP0002067_abnormal_sensory_capabilities0.78897818
103MP0009672_abnormal_birth_weight0.78486332
104MP0000678_abnormal_parathyroid_gland0.78375470
105MP0002277_abnormal_respiratory_mucosa0.78097815
106* MP0003755_abnormal_palate_morphology0.77882897
107* MP0002092_abnormal_eye_morphology0.76777555
108MP0003787_abnormal_imprinting0.76702000
109MP0000383_abnormal_hair_follicle0.76409110
110MP0003942_abnormal_urinary_system0.75834978
111MP0001963_abnormal_hearing_physiology0.75496718
112MP0010386_abnormal_urinary_bladder0.74298688
113* MP0000428_abnormal_craniofacial_morphol0.74105593
114MP0008932_abnormal_embryonic_tissue0.73632630
115MP0002932_abnormal_joint_morphology0.73582636
116MP0003077_abnormal_cell_cycle0.73300758
117MP0002332_abnormal_exercise_endurance0.72535059
118MP0002557_abnormal_social/conspecific_i0.72498800
119MP0000350_abnormal_cell_proliferation0.72298889
120* MP0002081_perinatal_lethality0.70187126
121MP0000955_abnormal_spinal_cord0.69765776
122MP0002272_abnormal_nervous_system0.68325612
123MP0000432_abnormal_head_morphology0.67091699
124MP0004742_abnormal_vestibular_system0.65726101
125* MP0002116_abnormal_craniofacial_bone0.64599741
126MP0003137_abnormal_impulse_conducting0.63897872
127* MP0005197_abnormal_uvea_morphology0.63871128
128MP0003634_abnormal_glial_cell0.63451475
129MP0002282_abnormal_trachea_morphology0.62799657
130MP0002734_abnormal_mechanical_nocicepti0.62558090
131MP0003315_abnormal_perineum_morphology0.61739002
132MP0008961_abnormal_basal_metabolism0.61537345
133MP0005076_abnormal_cell_differentiation0.61212140
134MP0004811_abnormal_neuron_physiology0.59351361
135MP0003122_maternal_imprinting0.59139962
136MP0010094_abnormal_chromosome_stability0.58479553
137MP0002249_abnormal_larynx_morphology0.58378651
138* MP0001697_abnormal_embryo_size0.58361410

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.09100352
2Pendular nystagmus (HP:0012043)8.00492988
3Abnormal rod and cone electroretinograms (HP:0008323)7.44046592
4Severe visual impairment (HP:0001141)7.40479887
5Absent rod-and cone-mediated responses on ERG (HP:0007688)6.82306156
6Abnormality of macular pigmentation (HP:0008002)6.61310342
7Bony spicule pigmentary retinopathy (HP:0007737)6.47604801
8Chorioretinal atrophy (HP:0000533)6.42969949
9Scotoma (HP:0000575)6.13387768
10Increased corneal curvature (HP:0100692)6.10982370
11Keratoconus (HP:0000563)6.10982370
12Abolished electroretinogram (ERG) (HP:0000550)5.92760056
13Decreased central vision (HP:0007663)5.68617214
14Posterior subcapsular cataract (HP:0007787)5.58393178
15Supernumerary spleens (HP:0009799)4.87556587
16Cone-rod dystrophy (HP:0000548)4.78092764
17Pigmentary retinal degeneration (HP:0001146)4.32235020
18Attenuation of retinal blood vessels (HP:0007843)4.18821655
19Type II diabetes mellitus (HP:0005978)4.13919276
20Dyschromatopsia (HP:0007641)4.03332883
21Abnormality of the labia minora (HP:0012880)3.96962668
22Constricted visual fields (HP:0001133)3.75105863
23Photophobia (HP:0000613)3.74129306
24Macular degeneration (HP:0000608)3.65322839
25Anophthalmia (HP:0000528)3.18222303
26Subcapsular cataract (HP:0000523)3.15832243
27Colon cancer (HP:0003003)3.06673361
28Esophageal atresia (HP:0002032)2.97690755
29True hermaphroditism (HP:0010459)2.87683040
30Abnormal lung lobation (HP:0002101)2.84105455
31* Absent septum pellucidum (HP:0001331)2.84083300
32Reticulocytopenia (HP:0001896)2.83817353
33Vitreoretinal degeneration (HP:0000655)2.83105572
34Chromsome breakage (HP:0040012)2.82525457
35Median cleft lip (HP:0000161)2.82195815
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75083118
37Retinitis pigmentosa (HP:0000510)2.72629572
38Absent radius (HP:0003974)2.67794168
39* Septo-optic dysplasia (HP:0100842)2.67583831
40Aplasia involving forearm bones (HP:0009822)2.57351411
41Absent forearm bone (HP:0003953)2.57351411
42Triphalangeal thumb (HP:0001199)2.54910252
43Sclerocornea (HP:0000647)2.54203009
44Pancreatic fibrosis (HP:0100732)2.53732534
45* Abnormality of the septum pellucidum (HP:0007375)2.52400740
46Meckel diverticulum (HP:0002245)2.51348992
47Gastrointestinal atresia (HP:0002589)2.50472403
48Impulsivity (HP:0100710)2.48896400
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.44153729
50Facial hemangioma (HP:0000329)2.42485226
51Abnormal number of incisors (HP:0011064)2.39793931
52Gonadotropin excess (HP:0000837)2.39628170
53Gait imbalance (HP:0002141)2.39207206
54Congenital primary aphakia (HP:0007707)2.37113818
55Abnormality of the ileum (HP:0001549)2.36492637
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.28051209
57Hypoplasia of the fovea (HP:0007750)2.28051209
58Hyperglycinemia (HP:0002154)2.23573813
59Short tibia (HP:0005736)2.23255975
60Anterior segment dysgenesis (HP:0007700)2.21723816
61Abnormality of the fovea (HP:0000493)2.20354080
62Partial duplication of thumb phalanx (HP:0009944)2.19274135
63Nephrogenic diabetes insipidus (HP:0009806)2.19084833
64Pancreatic cysts (HP:0001737)2.18551404
65Severe Myopia (HP:0011003)2.17773909
66Abnormality of the phalanges of the 2nd finger (HP:0009541)2.16116550
67Abnormal ciliary motility (HP:0012262)2.15287076
68Abnormality of the duodenum (HP:0002246)2.15075979
69Horseshoe kidney (HP:0000085)2.14719340
70Medial flaring of the eyebrow (HP:0010747)2.11137579
71* Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09785219
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.08365989
73Abnormality of chromosome stability (HP:0003220)2.07325941
74Hypoplastic pelvis (HP:0008839)2.06524302
75Partial duplication of the phalanx of hand (HP:0009999)2.03091471
76Choroideremia (HP:0001139)2.01681096
77Congenital stationary night blindness (HP:0007642)10.4813224
78Aqueductal stenosis (HP:0002410)1.96697436
79* Abnormality of abdominal situs (HP:0011620)1.95538224
80* Abdominal situs inversus (HP:0003363)1.95538224
81Preaxial foot polydactyly (HP:0001841)1.94913938
82Epileptic encephalopathy (HP:0200134)1.93648401
83Small intestinal stenosis (HP:0012848)1.92639614
84Duodenal stenosis (HP:0100867)1.92639614
85Abnormal respiratory motile cilium physiology (HP:0012261)1.91027180
86Ectopic kidney (HP:0000086)1.90985052
87Hepatoblastoma (HP:0002884)1.90176189
88Aplasia/Hypoplasia of the macula (HP:0008059)1.88751297
89Bile duct proliferation (HP:0001408)1.87530277
90Abnormal biliary tract physiology (HP:0012439)1.87530277
91Postaxial hand polydactyly (HP:0001162)1.87217727
92Duplication of thumb phalanx (HP:0009942)1.85343201
93Hemivertebrae (HP:0002937)1.85336287
94Chronic hepatic failure (HP:0100626)1.85096100
95Cystic liver disease (HP:0006706)1.84247832
96Nephroblastoma (Wilms tumor) (HP:0002667)1.84208916
97Abnormality of the labia (HP:0000058)1.83926069
98* Maternal diabetes (HP:0009800)1.82832408
99Wide nasal bridge (HP:0000431)1.82293418
100Rhinitis (HP:0012384)1.78574535
101Vaginal atresia (HP:0000148)1.78447604
102Anencephaly (HP:0002323)1.78388748
103Poor coordination (HP:0002370)1.78084960
104Dandy-Walker malformation (HP:0001305)1.77732664
105Optic disc pallor (HP:0000543)1.77485349
106Embryonal renal neoplasm (HP:0011794)1.75971529
107Cholecystitis (HP:0001082)1.75873146
108Abnormal gallbladder physiology (HP:0012438)1.75873146
109Abnormality of the parathyroid morphology (HP:0011766)1.74878265
110Breast aplasia (HP:0100783)1.74819425
111Genital tract atresia (HP:0001827)1.73642225
112Macrocytic anemia (HP:0001972)1.73480829
113Aplasia/Hypoplasia affecting the retina (HP:0008061)1.72159231
114Aplasia/Hypoplasia of the ulna (HP:0006495)1.71234252
115High anterior hairline (HP:0009890)1.71108226
116Chorioretinal coloboma (HP:0000567)1.70305435
117Elfin facies (HP:0004428)1.69036515
118Midline defect of the nose (HP:0004122)1.68028604
119Volvulus (HP:0002580)1.67927513
120Osteomalacia (HP:0002749)1.66954322
121Aplasia/Hypoplasia of the lens (HP:0008063)1.66722626
122Progressive visual loss (HP:0000529)1.61142568
123Abnormality of midbrain morphology (HP:0002418)1.61136215
124Molar tooth sign on MRI (HP:0002419)1.61136215
125Ependymoma (HP:0002888)1.60191308
126Decreased electroretinogram (ERG) amplitude (HP:0000654)1.59648216
127Growth hormone deficiency (HP:0000824)1.57965269
128Renal duplication (HP:0000075)1.56443968
129Bifid tongue (HP:0010297)1.54822550
130Postaxial foot polydactyly (HP:0001830)1.52359867
131Intestinal atresia (HP:0011100)1.49647500
132Preaxial hand polydactyly (HP:0001177)1.49079780
133Neoplasm of the oral cavity (HP:0100649)1.48996451
134* Aplasia/Hypoplasia of the tongue (HP:0010295)1.47254648
135Specific learning disability (HP:0001328)1.47112000
136Flat cornea (HP:0007720)1.46277454
137Down-sloping shoulders (HP:0200021)1.45791530
138Oligodactyly (hands) (HP:0001180)1.44360106
139Febrile seizures (HP:0002373)1.44325506
140Increased nuchal translucency (HP:0010880)1.43945197
141Bilateral microphthalmos (HP:0007633)1.43534400
142Oligodactyly (HP:0012165)1.41283962
143Anal stenosis (HP:0002025)1.41164193
144Albinism (HP:0001022)1.40661121
145Concave nail (HP:0001598)1.40574195
146Labial hypoplasia (HP:0000066)1.40280551
147Polar cataract (HP:0010696)1.39235508
148Renovascular hypertension (HP:0100817)1.38430372
149Stenosis of the external auditory canal (HP:0000402)1.36192845
150Astigmatism (HP:0000483)1.35913957
151Partial agenesis of the corpus callosum (HP:0001338)1.34953816
152Astrocytoma (HP:0009592)1.33751103
153Abnormality of the astrocytes (HP:0100707)1.33751103
154Nephronophthisis (HP:0000090)1.32848432
155Medulloblastoma (HP:0002885)1.31187159
156Renal hypoplasia (HP:0000089)1.30423490
157* Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.29926973
158Hyperacusis (HP:0010780)1.29052882
159* Optic nerve hypoplasia (HP:0000609)1.28636394
160Optic nerve coloboma (HP:0000588)1.28510686
161* Holoprosencephaly (HP:0001360)1.27623372
162Hypoplastic female external genitalia (HP:0012815)1.27593041
163Obsessive-compulsive behavior (HP:0000722)1.27165862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.63037635
2NEK13.98654292
3IRAK22.97630963
4TNIK2.67863203
5BUB12.31092500
6MAP3K102.30181892
7TRIM282.26137512
8EPHA42.25501768
9BRSK22.23182660
10ZAK2.22278846
11EPHB22.17013909
12SRPK12.14230091
13PAK62.12592885
14NEK22.10278713
15STK38L2.08967405
16BRD42.01442697
17CDK192.00605807
18PNCK1.92927166
19MKNK11.91351918
20CDC71.90618425
21ERBB31.89035307
22KSR11.80196631
23GRK11.79492677
24PRPF4B1.79016591
25VRK21.77423671
26VRK11.74381604
27BMPR1B1.72577890
28DYRK1A1.70515128
29NUAK11.68076683
30ERBB21.66782093
31PLK41.65884537
32TAOK21.59093794
33CDK31.54966343
34MARK11.52862664
35DYRK31.51685944
36ACVR1B1.50890840
37TGFBR11.45580717
38DYRK1B1.44084430
39PLK31.43676774
40STK241.41703203
41FGFR11.41575373
42NME11.39134718
43ICK1.35429380
44ARAF1.33741047
45MKNK21.33691303
46BRSK11.28422892
47CDK121.27943626
48CHEK21.26135658
49STK31.25357795
50STK381.23686649
51INSRR1.23673377
52ATR1.21918874
53BRAF1.21746411
54STK161.16809308
55ERBB41.16152714
56RPS6KA41.15347739
57CASK1.13626662
58MAP4K21.12671102
59SGK4941.11143438
60SGK2231.11143438
61TTK1.10708074
62NEK61.10635448
63PHKG21.09683369
64PHKG11.09683369
65CSNK1G11.03339382
66PLK10.94566954
67CHEK10.93479767
68MINK10.92528156
69MAP3K40.91592900
70PKN20.88715875
71WNK30.88534349
72HIPK20.87315096
73CDK90.87068121
74CDK10.84391528
75WEE10.82168511
76UHMK10.80716815
77CAMK1G0.80404570
78PINK10.79374000
79CDK80.79283458
80EIF2AK30.78177194
81MET0.77933571
82CDK70.77252443
83MAPK130.76658292
84ATM0.76384711
85PASK0.76308960
86CDK20.76026326
87BCR0.75868000
88CSNK1G20.74180661
89CSNK1E0.73806681
90PLK20.73562689
91CSNK1G30.71185635
92TAF10.69117494
93GSK3B0.68982476
94AKT20.66840472
95MAPK90.66095874
96RPS6KB20.65388356
97FGFR20.65121284
98RIPK10.64743839
99LATS10.63550642
100PAK30.62049007
101DYRK20.61940144
102MAPK140.61868033
103TIE10.61803642
104MELK0.61791723
105NLK0.60904648
106MAP3K90.58927111
107CSNK1D0.58924154
108MAPK100.58497020
109RPS6KA50.58458834
110PRKCI0.58325141
111AURKA0.57906953
112SIK20.56602749
113OXSR10.55119264
114MAP3K130.54511612
115STK390.54421847
116CDC42BPA0.53559548
117CDK11A0.53287087
118CAMK1D0.53241873
119CAMK2D0.52665188
120CDK60.52462127
121AURKB0.51999168
122MOS0.51443095
123CDK140.51319996
124CDK180.50895748
125CDK150.50429806
126MTOR0.49547127
127PRKCG0.47938521
128PRKAA10.47408924
129MST40.47003783
130PKN10.46753351
131MAP2K70.45890106
132TLK10.45690905
133PRKDC0.43872261
134MAPK150.43612414
135TSSK60.43516509
136TYRO30.43439186
137LATS20.40736204
138PRKD20.40589617
139CLK10.40374986
140IRAK10.40237655
141CSNK1A1L0.39967743
142AKT10.39110139
143NTRK20.37931483
144PRKCZ0.37554324
145EIF2AK20.37147744
146STK40.36852111
147PRKG10.36083702
148CSNK2A10.35237075

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047448.06717825
2Synaptic vesicle cycle_Homo sapiens_hsa047212.97582217
3GABAergic synapse_Homo sapiens_hsa047272.69582989
4Nicotine addiction_Homo sapiens_hsa050332.49844056
5Spliceosome_Homo sapiens_hsa030402.42811937
6Circadian rhythm_Homo sapiens_hsa047102.23206817
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.16229158
8Non-homologous end-joining_Homo sapiens_hsa034502.06985296
9Morphine addiction_Homo sapiens_hsa050322.02399903
10Basal cell carcinoma_Homo sapiens_hsa052171.92524730
11Protein export_Homo sapiens_hsa030601.91869244
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90786426
13mRNA surveillance pathway_Homo sapiens_hsa030151.87132571
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.86239466
15Oxidative phosphorylation_Homo sapiens_hsa001901.84056923
16Parkinsons disease_Homo sapiens_hsa050121.79605401
17Fructose and mannose metabolism_Homo sapiens_hsa000511.75931994
18Notch signaling pathway_Homo sapiens_hsa043301.75354212
19Huntingtons disease_Homo sapiens_hsa050161.70557507
20Circadian entrainment_Homo sapiens_hsa047131.70133108
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68600825
22Biosynthesis of amino acids_Homo sapiens_hsa012301.67227049
23RNA degradation_Homo sapiens_hsa030181.59792939
24Propanoate metabolism_Homo sapiens_hsa006401.53817918
25Olfactory transduction_Homo sapiens_hsa047401.51449773
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50563693
27Mismatch repair_Homo sapiens_hsa034301.50556890
28RNA transport_Homo sapiens_hsa030131.49387876
29Hedgehog signaling pathway_Homo sapiens_hsa043401.43508392
30p53 signaling pathway_Homo sapiens_hsa041151.42463654
31Caffeine metabolism_Homo sapiens_hsa002321.40714753
32Hippo signaling pathway_Homo sapiens_hsa043901.39175112
33Proteasome_Homo sapiens_hsa030501.37743007
34Steroid biosynthesis_Homo sapiens_hsa001001.37562566
35Folate biosynthesis_Homo sapiens_hsa007901.36663179
36Cholinergic synapse_Homo sapiens_hsa047251.34655618
37mTOR signaling pathway_Homo sapiens_hsa041501.28956065
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22903487
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22742313
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21438279
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18040798
42DNA replication_Homo sapiens_hsa030301.14837872
43Axon guidance_Homo sapiens_hsa043601.13901918
44Wnt signaling pathway_Homo sapiens_hsa043101.11025183
45Base excision repair_Homo sapiens_hsa034101.09727544
46Glutamatergic synapse_Homo sapiens_hsa047241.07555299
47Dopaminergic synapse_Homo sapiens_hsa047281.07177519
48Alcoholism_Homo sapiens_hsa050341.05122052
49Fanconi anemia pathway_Homo sapiens_hsa034601.02585312
50Lysine degradation_Homo sapiens_hsa003101.00994794
51HIF-1 signaling pathway_Homo sapiens_hsa040661.00969197
52Insulin secretion_Homo sapiens_hsa049111.00860522
53Cell cycle_Homo sapiens_hsa041100.98592115
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.98076835
55Serotonergic synapse_Homo sapiens_hsa047260.97282170
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96603313
57Colorectal cancer_Homo sapiens_hsa052100.96273044
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95485231
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93517135
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93420193
61Galactose metabolism_Homo sapiens_hsa000520.91659126
62Ovarian steroidogenesis_Homo sapiens_hsa049130.90824348
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89105725
64Cardiac muscle contraction_Homo sapiens_hsa042600.89090312
65Nucleotide excision repair_Homo sapiens_hsa034200.88892103
66Alzheimers disease_Homo sapiens_hsa050100.88494564
67RNA polymerase_Homo sapiens_hsa030200.85586172
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84726642
69Renal cell carcinoma_Homo sapiens_hsa052110.83863024
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83354330
71Fatty acid elongation_Homo sapiens_hsa000620.83335583
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82495495
73Purine metabolism_Homo sapiens_hsa002300.82247428
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79198839
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77607274
76Retinol metabolism_Homo sapiens_hsa008300.75269192
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75189539
78One carbon pool by folate_Homo sapiens_hsa006700.73897524
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73442783
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72189412
81Endometrial cancer_Homo sapiens_hsa052130.68674687
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66781425
83Oocyte meiosis_Homo sapiens_hsa041140.66290715
84Thyroid cancer_Homo sapiens_hsa052160.65128675
85Pentose phosphate pathway_Homo sapiens_hsa000300.64566441
86Butanoate metabolism_Homo sapiens_hsa006500.64283731
87Melanoma_Homo sapiens_hsa052180.62993500
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.62928463
89Selenocompound metabolism_Homo sapiens_hsa004500.62869029
90Oxytocin signaling pathway_Homo sapiens_hsa049210.62528196
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59724531
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58729241
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58701092
94Gap junction_Homo sapiens_hsa045400.58313367
95Collecting duct acid secretion_Homo sapiens_hsa049660.57380075
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57047613
97Vitamin digestion and absorption_Homo sapiens_hsa049770.56825058
98Arginine and proline metabolism_Homo sapiens_hsa003300.56260470
99Melanogenesis_Homo sapiens_hsa049160.53026810
100Carbon metabolism_Homo sapiens_hsa012000.52977671
101Pathways in cancer_Homo sapiens_hsa052000.52674284
102Renin secretion_Homo sapiens_hsa049240.51228196
103Basal transcription factors_Homo sapiens_hsa030220.50377519
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49993250
105Dilated cardiomyopathy_Homo sapiens_hsa054140.49699895
106Glucagon signaling pathway_Homo sapiens_hsa049220.49572889
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48622239
108Metabolic pathways_Homo sapiens_hsa011000.47237671
109Type II diabetes mellitus_Homo sapiens_hsa049300.46927619
110Homologous recombination_Homo sapiens_hsa034400.44746066
111Linoleic acid metabolism_Homo sapiens_hsa005910.43911670
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42948164
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42540370
114Adherens junction_Homo sapiens_hsa045200.42527226
115MicroRNAs in cancer_Homo sapiens_hsa052060.42245270
116AMPK signaling pathway_Homo sapiens_hsa041520.41236243
117HTLV-I infection_Homo sapiens_hsa051660.41127881
118Peroxisome_Homo sapiens_hsa041460.41055010
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40696659
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40381259
121Pyrimidine metabolism_Homo sapiens_hsa002400.40189975
122Salivary secretion_Homo sapiens_hsa049700.39760179
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39742610
124Taste transduction_Homo sapiens_hsa047420.39643586
125Ribosome_Homo sapiens_hsa030100.39420932
126Nitrogen metabolism_Homo sapiens_hsa009100.38685958
127Mineral absorption_Homo sapiens_hsa049780.37962387
128Pyruvate metabolism_Homo sapiens_hsa006200.37230007
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37184956
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36612061
131beta-Alanine metabolism_Homo sapiens_hsa004100.35291744
132TGF-beta signaling pathway_Homo sapiens_hsa043500.34953687
133Tight junction_Homo sapiens_hsa045300.34380691
134Regulation of autophagy_Homo sapiens_hsa041400.33696574
135Inositol phosphate metabolism_Homo sapiens_hsa005620.32677462
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.32421688
137Cocaine addiction_Homo sapiens_hsa050300.30854483
138Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30691948
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30420424
140Glutathione metabolism_Homo sapiens_hsa004800.29686673
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27758575
142Systemic lupus erythematosus_Homo sapiens_hsa053220.26348820
143Tryptophan metabolism_Homo sapiens_hsa003800.25153623
1442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24701265

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