OVCH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)9.10811737
2single fertilization (GO:0007338)8.65505630
3heterotypic cell-cell adhesion (GO:0034113)8.55479679
4indolalkylamine catabolic process (GO:0046218)8.52723686
5tryptophan catabolic process (GO:0006569)8.52723686
6indole-containing compound catabolic process (GO:0042436)8.52723686
7positive regulation of type 2 immune response (GO:0002830)7.45679122
8regulation of mesoderm development (GO:2000380)7.45652908
9negative regulation of interleukin-10 production (GO:0032693)7.34728262
10tryptophan metabolic process (GO:0006568)7.32961212
11negative regulation of activin receptor signaling pathway (GO:0032926)6.93991046
12aromatic amino acid family catabolic process (GO:0009074)5.83430957
13fertilization (GO:0009566)5.70410043
14cell migration involved in gastrulation (GO:0042074)5.53353225
15anterior/posterior axis specification, embryo (GO:0008595)5.48942159
16cellular biogenic amine catabolic process (GO:0042402)5.48289943
17amine catabolic process (GO:0009310)5.48289943
18indolalkylamine metabolic process (GO:0006586)5.38248905
19sequestering of extracellular ligand from receptor (GO:0035581)5.30372492
20negative regulation of interleukin-8 production (GO:0032717)5.26060809
21regulation of activin receptor signaling pathway (GO:0032925)5.03385233
22endoderm formation (GO:0001706)4.84773386
23benzene-containing compound metabolic process (GO:0042537)4.80446351
24primitive streak formation (GO:0090009)4.69978473
25pericardium development (GO:0060039)4.63745892
26digestion (GO:0007586)4.62680301
27epithelial cell morphogenesis (GO:0003382)4.42058547
28negative regulation of T cell apoptotic process (GO:0070233)4.38485754
29negative regulation of endopeptidase activity (GO:0010951)4.37339791
30positive regulation of cell-cell adhesion (GO:0022409)4.33069373
31phospholipid scrambling (GO:0017121)4.24462660
32nodal signaling pathway (GO:0038092)4.23271716
33aromatic amino acid family metabolic process (GO:0009072)4.21978542
34signal transduction involved in regulation of gene expression (GO:0023019)4.18796265
35female gonad development (GO:0008585)4.18595819
36anterior/posterior axis specification (GO:0009948)4.18452025
37negative regulation of peptidase activity (GO:0010466)4.17683572
38somite rostral/caudal axis specification (GO:0032525)4.01850709
39transepithelial transport (GO:0070633)3.97140263
40regulation of type 2 immune response (GO:0002828)3.88102280
41interkinetic nuclear migration (GO:0022027)3.86100541
42indole-containing compound metabolic process (GO:0042430)3.83065454
43response to BMP (GO:0071772)3.82488264
44cellular response to BMP stimulus (GO:0071773)3.82488264
45regulation of clathrin-mediated endocytosis (GO:2000369)3.78209881
46positive regulation of gastrulation (GO:2000543)3.69320282
47DNA double-strand break processing (GO:0000729)3.65825905
48reverse cholesterol transport (GO:0043691)3.63768724
49embryonic axis specification (GO:0000578)3.61523808
50N-terminal protein amino acid acetylation (GO:0006474)3.58439037
51defense response to bacterium (GO:0042742)3.54734611
52sulfur amino acid catabolic process (GO:0000098)3.53850844
53gastrulation (GO:0007369)3.50946782
54genitalia morphogenesis (GO:0035112)3.49267962
55embryonic pattern specification (GO:0009880)3.48832359
56positive regulation of SMAD protein import into nucleus (GO:0060391)3.47050496
57branching involved in labyrinthine layer morphogenesis (GO:0060670)3.45506079
58regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.37773902
59N-acetylneuraminate metabolic process (GO:0006054)3.36788827
60kidney morphogenesis (GO:0060993)3.36567216
61monoubiquitinated protein deubiquitination (GO:0035520)3.36265457
62negative regulation of protein autophosphorylation (GO:0031953)3.35618212
63negative regulation of translation, ncRNA-mediated (GO:0040033)3.31748800
64regulation of translation, ncRNA-mediated (GO:0045974)3.31748800
65negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.31748800
66mitotic G2/M transition checkpoint (GO:0044818)3.29640468
67negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.29639394
68positive regulation of cardiac muscle cell proliferation (GO:0060045)3.28044463
69extracellular negative regulation of signal transduction (GO:1900116)3.27459120
70extracellular regulation of signal transduction (GO:1900115)3.27459120
71embryonic foregut morphogenesis (GO:0048617)3.26569210
72negative regulation of DNA repair (GO:0045738)3.25652339
73regulation of gastrulation (GO:0010470)3.20847083
74regulation of macrophage activation (GO:0043030)3.15497500
75phospholipid homeostasis (GO:0055091)3.15146419
76histone exchange (GO:0043486)3.14727230
77DNA replication-dependent nucleosome assembly (GO:0006335)3.14398228
78DNA replication-dependent nucleosome organization (GO:0034723)3.14398228
79embryonic camera-type eye development (GO:0031076)3.13603545
80activin receptor signaling pathway (GO:0032924)3.09959421
81fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.09326254
82response to bacterium (GO:0009617)3.06638897
83regulation of meiosis I (GO:0060631)3.05742584
84alpha-linolenic acid metabolic process (GO:0036109)3.05232754
85cell wall macromolecule catabolic process (GO:0016998)3.01859180
86regulation of timing of cell differentiation (GO:0048505)3.01272514
87seminiferous tubule development (GO:0072520)25.1084017
88keratinocyte development (GO:0003334)2.97177735
89regulation of lipoprotein metabolic process (GO:0050746)2.96615437
90cilium or flagellum-dependent cell motility (GO:0001539)2.95964068
91multicellular organism reproduction (GO:0032504)2.93024591
92retinal cone cell development (GO:0046549)2.92482340
93positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.92387639
94regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.92217279
95positive regulation of cardiac muscle tissue growth (GO:0055023)2.92001862
96cellular response to electrical stimulus (GO:0071257)2.88729153
97positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.82618025
98female gamete generation (GO:0007292)2.82198271
99regulation of cardioblast differentiation (GO:0051890)2.81226287
100negative regulation of proteolysis (GO:0045861)2.81210622
101regulation of MHC class II biosynthetic process (GO:0045346)2.77832450
102glial cell proliferation (GO:0014009)2.77082081
103CENP-A containing nucleosome assembly (GO:0034080)2.75787325
104negative regulation of hormone biosynthetic process (GO:0032353)2.72989495
105regulation of beta-amyloid formation (GO:1902003)2.72118907
106negative regulation of protein processing (GO:0010955)2.71373802
107negative regulation of protein maturation (GO:1903318)2.71373802
108O-glycan processing (GO:0016266)2.71258042
109regulation of activated T cell proliferation (GO:0046006)2.71154284
110axis specification (GO:0009798)2.70376084
111cysteine metabolic process (GO:0006534)2.69709668
112cell wall macromolecule metabolic process (GO:0044036)2.69229968
113sialylation (GO:0097503)2.69144139
114complement activation, alternative pathway (GO:0006957)2.67854221
115positive regulation of cellular amide metabolic process (GO:0034250)2.67666410
116DNA integration (GO:0015074)2.66857497
117negative regulation of lymphocyte apoptotic process (GO:0070229)2.66324638
118negative regulation of glycogen biosynthetic process (GO:0045719)2.66007529
119pre-miRNA processing (GO:0031054)2.65852684
120positive regulation of cardiac muscle tissue development (GO:0055025)2.65250967
121ectoderm development (GO:0007398)2.65156134
122regulation of development, heterochronic (GO:0040034)2.64649853
123glomerular visceral epithelial cell development (GO:0072015)2.64409321
124regulation of tight junction assembly (GO:2000810)2.64198999
125bundle of His cell to Purkinje myocyte communication (GO:0086069)2.62748917
126chromatin remodeling at centromere (GO:0031055)2.62233264
127SMAD protein signal transduction (GO:0060395)2.62215723
128high-density lipoprotein particle remodeling (GO:0034375)2.62000258
129mitotic G2 DNA damage checkpoint (GO:0007095)2.60784606
130phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.59967329
131positive regulation of histone H3-K4 methylation (GO:0051571)2.59874271
132dorsal/ventral axis specification (GO:0009950)2.59629589
133positive regulation of interleukin-12 production (GO:0032735)2.57648162
134regulation of hippo signaling (GO:0035330)2.57409109
135resolution of meiotic recombination intermediates (GO:0000712)2.56441343
136photoreceptor cell maintenance (GO:0045494)2.56435011
137reciprocal DNA recombination (GO:0035825)2.54962018
138reciprocal meiotic recombination (GO:0007131)2.54962018
139regulation of establishment of cell polarity (GO:2000114)2.54656947
140regulation of cardiac muscle cell proliferation (GO:0060043)2.53416388
141synapsis (GO:0007129)2.53289617
142outflow tract septum morphogenesis (GO:0003148)2.53234221
143DNA replication checkpoint (GO:0000076)2.52666295
144negative regulation of hydrolase activity (GO:0051346)2.52190659
145regulation of acrosome reaction (GO:0060046)2.51930529
146regulation of acyl-CoA biosynthetic process (GO:0050812)2.51591907
147low-density lipoprotein particle clearance (GO:0034383)2.50745487
148negative regulation of sodium ion transport (GO:0010766)2.49986865
149columnar/cuboidal epithelial cell development (GO:0002066)2.49839235
150hormone catabolic process (GO:0042447)2.49756075
151myelin assembly (GO:0032288)2.47305041
152negative regulation of receptor-mediated endocytosis (GO:0048261)2.46926263
153limb bud formation (GO:0060174)2.46550747
154organ formation (GO:0048645)2.44466366
155regulation of SMAD protein import into nucleus (GO:0060390)2.44281506
156regulation of amyloid precursor protein catabolic process (GO:1902991)2.44070925
157regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.43470101
158regulation of posttranscriptional gene silencing (GO:0060147)2.43103028
159regulation of gene silencing by miRNA (GO:0060964)2.43103028
160regulation of gene silencing by RNA (GO:0060966)2.43103028
161establishment of protein localization to Golgi (GO:0072600)2.42801078
162negative regulation of glycogen metabolic process (GO:0070874)2.39872517
163regulation of endopeptidase activity (GO:0052548)2.34686283
164L-serine transport (GO:0015825)2.32213960
165pyrimidine ribonucleoside catabolic process (GO:0046133)2.29905477
166lipid catabolic process (GO:0016042)2.29557404
167negative regulation of interleukin-6 production (GO:0032715)2.29199591
168alpha-amino acid catabolic process (GO:1901606)2.29001845
169valine metabolic process (GO:0006573)2.23902096
170regulation of peptidase activity (GO:0052547)2.22992536
171regulation of T cell apoptotic process (GO:0070232)2.22954165
172cellular amino acid catabolic process (GO:0009063)2.22457921
173triglyceride catabolic process (GO:0019433)2.20506086
174response to misfolded protein (GO:0051788)2.18533508
175L-phenylalanine catabolic process (GO:0006559)2.17047070
176erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.17047070
177neutral lipid catabolic process (GO:0046461)2.13930009
178acylglycerol catabolic process (GO:0046464)2.13930009
179regulation of interleukin-10 production (GO:0032653)2.12166151
180regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.10783705
181plasma lipoprotein particle remodeling (GO:0034369)2.10779396
182protein-lipid complex remodeling (GO:0034368)2.10779396
183macromolecular complex remodeling (GO:0034367)2.10779396
184positive regulation of cholesterol transport (GO:0032376)2.09468873
185positive regulation of sterol transport (GO:0032373)2.09468873
186myelin maintenance (GO:0043217)2.08394486
187cellular anion homeostasis (GO:0030002)2.07169076
188regulation of reproductive process (GO:2000241)2.05741951
189negative regulation of T cell proliferation (GO:0042130)2.05391426
190cellular response to epidermal growth factor stimulus (GO:0071364)2.03130937
191cellular modified amino acid catabolic process (GO:0042219)2.03052989
192serine transport (GO:0032329)2.01103014
193production of molecular mediator involved in inflammatory response (GO:0002532)14.4496470
194regulation of T cell tolerance induction (GO:0002664)14.3924832
195positive regulation of tolerance induction (GO:0002645)12.3405780
196sperm capacitation (GO:0048240)11.2644572
197regulation of tolerance induction (GO:0002643)10.7388581
198kynurenine metabolic process (GO:0070189)10.4327108
199glutamate metabolic process (GO:0006536)1.98936279
200negative regulation of tumor necrosis factor production (GO:0032720)1.98362117

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.64775289
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.18255385
3IKZF1_21737484_ChIP-ChIP_HCT116_Human4.06767189
4AR_21572438_ChIP-Seq_LNCaP_Human3.32793684
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.02128025
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.99456082
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.79605170
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.73513045
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.72371477
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.67886091
11SMAD3_21741376_ChIP-Seq_EPCs_Human2.67239139
12FUS_26573619_Chip-Seq_HEK293_Human2.59491053
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55263860
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.53659536
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.51895313
16GBX2_23144817_ChIP-Seq_PC3_Human2.46155677
17P300_19829295_ChIP-Seq_ESCs_Human2.45792312
18ZNF263_19887448_ChIP-Seq_K562_Human2.41588123
19SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.34580876
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.33773213
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27888620
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.23547322
23LXR_22158963_ChIP-Seq_LIVER_Mouse2.21334755
24DNAJC2_21179169_ChIP-ChIP_NT2_Human2.16340871
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13054452
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.06893029
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.06727509
28BCAT_22108803_ChIP-Seq_LS180_Human2.05147005
29ZNF274_21170338_ChIP-Seq_K562_Hela2.04986493
30TRIM28_21343339_ChIP-Seq_HEK293_Human2.03596090
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03365991
32VDR_22108803_ChIP-Seq_LS180_Human2.00477776
33SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.99991823
34SMAD4_21741376_ChIP-Seq_EPCs_Human1.99742965
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.93923712
36EWS_26573619_Chip-Seq_HEK293_Human1.93315033
37CLOCK_20551151_ChIP-Seq_293T_Human1.87708160
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.85789565
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.79750362
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.78461570
41GATA3_21867929_ChIP-Seq_TH1_Mouse1.77550681
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.77070134
43CBP_20019798_ChIP-Seq_JUKART_Human1.77070134
44PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76696242
45GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.76365830
46AR_25329375_ChIP-Seq_VCAP_Human1.76023540
47SMAD4_21799915_ChIP-Seq_A2780_Human1.70462015
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69234759
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68949166
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.68699502
51FOXM1_26456572_ChIP-Seq_MCF-7_Human1.67884759
52SMAD1_18555785_Chip-Seq_ESCs_Mouse1.65915231
53NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.65500949
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64656496
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63875123
56IGF1R_20145208_ChIP-Seq_DFB_Human1.63563096
57ER_23166858_ChIP-Seq_MCF-7_Human1.61708791
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.59991077
59AHR_22903824_ChIP-Seq_MCF-7_Human1.59213901
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59021996
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59021996
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58980632
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.58277641
64TCF4_22108803_ChIP-Seq_LS180_Human1.58012738
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57910960
66STAT3_23295773_ChIP-Seq_U87_Human1.57736285
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56040369
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.55132132
69RUNX2_22187159_ChIP-Seq_PCA_Human1.54648752
70REST_19997604_ChIP-ChIP_NEURONS_Mouse1.54321583
71TCF4_23295773_ChIP-Seq_U87_Human1.54103355
72SMAD4_21741376_ChIP-Seq_HESCs_Human1.53118242
73CDX2_22108803_ChIP-Seq_LS180_Human1.51848357
74FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51562476
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.51375377
76TP53_16413492_ChIP-PET_HCT116_Human1.50844183
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49233030
78STAT1_17558387_ChIP-Seq_HELA_Human1.48487705
79FLI1_21867929_ChIP-Seq_CD8_Mouse1.46231196
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45730050
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45617056
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45617056
83TAF15_26573619_Chip-Seq_HEK293_Human1.44993326
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.44581668
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42397844
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42397844
87SOX2_22085726_ChIP-Seq_NPCs_Mouse1.41551425
88ESRRB_18555785_Chip-Seq_ESCs_Mouse1.40872591
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40249100
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39203275
91NANOG_19829295_ChIP-Seq_ESCs_Human1.38780620
92SOX2_19829295_ChIP-Seq_ESCs_Human1.38780620
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37985600
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37605617
95SMAD3_21741376_ChIP-Seq_HESCs_Human1.35293963
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34820538
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34441488
98TP53_18474530_ChIP-ChIP_U2OS_Human1.33953831
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.29266044
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26856096
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25944866
102GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.25845794
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25232009
104SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23872992
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23748709
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.23545546
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22806905
108TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.22321150
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.20934272
110EZH2_22144423_ChIP-Seq_EOC_Human1.20611724
111CTCF_18555785_Chip-Seq_ESCs_Mouse1.19067099
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18713349
113CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18433261
114TP63_23658742_ChIP-Seq_EP156T_Human1.18426688
115* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18291574
116TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15735362
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.15213268
118MYC_27129775_Chip-Seq_CORNEA_Mouse1.15007093
119TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14941705
120MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14263460
121NFE2_27457419_Chip-Seq_LIVER_Mouse1.14139320
122* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13905353
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13798339
124EOMES_21245162_ChIP-Seq_HESCs_Human1.13641611
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12628178
126BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.12166834
127VDR_24787735_ChIP-Seq_THP-1_Human1.12055017
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11853761
129JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11804504
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11689872
131SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11622951
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11552025
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10886229
134SMC4_20622854_ChIP-Seq_HELA_Human1.10875640
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10366076
136CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09957461
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09470512
138BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.09237542
139CBX2_27304074_Chip-Seq_ESCs_Mouse1.08954711
140RACK7_27058665_Chip-Seq_MCF-7_Human1.08743096
141MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08715363
142SALL4_22934838_ChIP-ChIP_CD34+_Human1.08575625
143NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08345166
144POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08012111
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07646809
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07506108
147TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07339724
148CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06062608
149NANOG_18555785_Chip-Seq_ESCs_Mouse1.05978737
150SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05637318
151SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05153390
152KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04013450
153KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04013450
154KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04013450
155MYC_19915707_ChIP-ChIP_AK7_Human1.03821369
156SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03743134
157EZH2_27304074_Chip-Seq_ESCs_Mouse1.00545273
158ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98999842
159FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98480589
160KDM2B_26808549_Chip-Seq_REH_Human0.98223344
161TP53_20018659_ChIP-ChIP_R1E_Mouse0.98090620
162SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97616635
163EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96971481
164REST_18959480_ChIP-ChIP_MESCs_Mouse0.96852212
165ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95592529
166EZH2_27294783_Chip-Seq_NPCs_Mouse0.95514384
167DROSHA_22980978_ChIP-Seq_HELA_Human0.94859747
168SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94168744
169FOXH1_21741376_ChIP-Seq_ESCs_Human0.93712296
170ERG_21242973_ChIP-ChIP_JURKAT_Human0.93400682
171BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92753619
172BCL6_27268052_Chip-Seq_Bcells_Human0.91337064
173PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91193773
174SOX2_18555785_Chip-Seq_ESCs_Mouse0.90096419
175ETS1_21867929_ChIP-Seq_TH2_Mouse0.88137350
176NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86950040
177SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86327318
178KDM2B_26808549_Chip-Seq_K562_Human0.85872439
179SOX2_20726797_ChIP-Seq_SW620_Human0.85097108
180RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84916096
181KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84794760
182LXR_22292898_ChIP-Seq_THP-1_Human0.84567177
183HTT_18923047_ChIP-ChIP_STHdh_Human0.83284756
184P300_27268052_Chip-Seq_Bcells_Human0.82926339
185JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81462280
186WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80879043
187RAC3_21632823_ChIP-Seq_H3396_Human0.80278549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry8.34626539
2MP0003303_peritoneal_inflammation5.78886942
3MP0003195_calcinosis5.16343093
4MP0002254_reproductive_system_inflammat5.07521224
5MP0004043_abnormal_pH_regulation4.66578259
6MP0010234_abnormal_vibrissa_follicle4.30999444
7MP0002139_abnormal_hepatobiliary_system4.10178773
8MP0008004_abnormal_stomach_pH4.05086355
9MP0010030_abnormal_orbit_morphology3.51909252
10MP0005499_abnormal_olfactory_system3.37185348
11MP0005394_taste/olfaction_phenotype3.37185348
12MP0005410_abnormal_fertilization3.33345899
13MP0005058_abnormal_lysosome_morphology3.04444501
14MP0003329_amyloid_beta_deposits3.04167645
15MP0003119_abnormal_digestive_system2.86581868
16MP0001984_abnormal_olfaction2.77904554
17MP0002102_abnormal_ear_morphology2.45045939
18MP0003718_maternal_effect2.33592744
19MP0000383_abnormal_hair_follicle2.28086192
20MP0000569_abnormal_digit_pigmentation2.21790537
21MP0006292_abnormal_olfactory_placode2.18916109
22MP0008057_abnormal_DNA_replication2.18379898
23MP0006054_spinal_hemorrhage2.15687110
24MP0000003_abnormal_adipose_tissue2.12465984
25MP0005360_urolithiasis2.10414447
26MP0000604_amyloidosis2.08365486
27MP0008877_abnormal_DNA_methylation2.03633238
28MP0010329_abnormal_lipoprotein_level1.98567801
29MP0004133_heterotaxia1.97176488
30MP0002168_other_aberrant_phenotype1.95538382
31MP0008789_abnormal_olfactory_epithelium1.89869042
32MP0000428_abnormal_craniofacial_morphol1.87236918
33MP0001986_abnormal_taste_sensitivity1.84984929
34MP0003300_gastrointestinal_ulcer1.81673140
35MP0005365_abnormal_bile_salt1.77170113
36MP0003566_abnormal_cell_adhesion1.69842842
37MP0004264_abnormal_extraembryonic_tissu1.69407859
38MP0004885_abnormal_endolymph1.67861665
39MP0001440_abnormal_grooming_behavior1.64516592
40MP0001501_abnormal_sleep_pattern1.63155777
41MP0002138_abnormal_hepatobiliary_system1.62604505
42MP0004130_abnormal_muscle_cell1.53805341
43MP0001765_abnormal_ion_homeostasis1.53253999
44MP0005085_abnormal_gallbladder_physiolo1.52537680
45MP0001286_abnormal_eye_development1.50490643
46MP0005375_adipose_tissue_phenotype1.49288645
47MP0001853_heart_inflammation1.44043669
48MP0004859_abnormal_synaptic_plasticity1.43134424
49MP0002837_dystrophic_cardiac_calcinosis1.42685321
50MP0005367_renal/urinary_system_phenotyp1.42167956
51MP0000516_abnormal_urinary_system1.42167956
52MP0003937_abnormal_limbs/digits/tail_de1.39791365
53MP0000534_abnormal_ureter_morphology1.38818452
54MP0002233_abnormal_nose_morphology1.37144872
55MP0001672_abnormal_embryogenesis/_devel1.36598541
56MP0005380_embryogenesis_phenotype1.36598541
57MP0008995_early_reproductive_senescence1.35795362
58MP0002084_abnormal_developmental_patter1.33716324
59MP0003705_abnormal_hypodermis_morpholog1.33295012
60MP0009643_abnormal_urine_homeostasis1.32862668
61MP0003690_abnormal_glial_cell1.32168093
62MP0005409_darkened_coat_color1.31946091
63MP0004858_abnormal_nervous_system1.30019559
64MP0004185_abnormal_adipocyte_glucose1.29166407
65MP0005174_abnormal_tail_pigmentation1.28588515
66MP0005423_abnormal_somatic_nervous1.27475337
67MP0000015_abnormal_ear_pigmentation1.24085831
68MP0001756_abnormal_urination1.22403860
69MP0005332_abnormal_amino_acid1.22105765
70MP0005083_abnormal_biliary_tract1.21986221
71MP0005551_abnormal_eye_electrophysiolog1.19834867
72MP0000537_abnormal_urethra_morphology1.19761729
73MP0009697_abnormal_copulation1.17841189
74MP0004270_analgesia1.17627327
75MP0002736_abnormal_nociception_after1.17152077
76MP0005275_abnormal_skin_tensile1.17016197
77MP0003880_abnormal_central_pattern1.16976077
78MP0005584_abnormal_enzyme/coenzyme_acti1.15660158
79MP0002127_abnormal_cardiovascular_syste1.15230127
80MP0002118_abnormal_lipid_homeostasis1.14946972
81MP0008438_abnormal_cutaneous_collagen1.14708841
82MP0003984_embryonic_growth_retardation1.12578467
83MP0002089_abnormal_postnatal_growth/wei1.10273986
84MP0005075_abnormal_melanosome_morpholog1.09547343
85MP0003935_abnormal_craniofacial_develop1.08595932
86MP0003646_muscle_fatigue1.08321885
87MP0003315_abnormal_perineum_morphology1.07399836
88MP0002896_abnormal_bone_mineralization1.07210030
89MP0002796_impaired_skin_barrier1.06537833
90MP0002088_abnormal_embryonic_growth/wei1.06442079
91MP0003075_altered_response_to1.04779676
92MP0000762_abnormal_tongue_morphology1.02513258
93MP0004145_abnormal_muscle_electrophysio1.01744086
94MP0003136_yellow_coat_color1.01453326
95MP0002111_abnormal_tail_morphology1.00125800
96MP0003755_abnormal_palate_morphology1.00120057
97MP0003191_abnormal_cellular_cholesterol1.00089514
98MP0003632_abnormal_nervous_system0.99541307
99MP0003567_abnormal_fetal_cardiomyocyte0.98671411
100MP0001293_anophthalmia0.98423810
101MP0005636_abnormal_mineral_homeostasis0.98069074
102MP0003941_abnormal_skin_development0.96415128
103MP0009780_abnormal_chondrocyte_physiolo0.94804524
104MP0003385_abnormal_body_wall0.94465761
105MP0004215_abnormal_myocardial_fiber0.93260810
106MP0003936_abnormal_reproductive_system0.92471451
107MP0005666_abnormal_adipose_tissue0.91516278
108MP0003252_abnormal_bile_duct0.91320144
109MP0002909_abnormal_adrenal_gland0.90706699
110MP0004381_abnormal_hair_follicle0.90618755
111MP0003806_abnormal_nucleotide_metabolis0.90571469
112MP0003698_abnormal_male_reproductive0.90252918
113MP0008875_abnormal_xenobiotic_pharmacok0.89931478
114MP0004084_abnormal_cardiac_muscle0.89861445
115MP0000920_abnormal_myelination0.89429604
116MP0008058_abnormal_DNA_repair0.88967128
117MP0003879_abnormal_hair_cell0.88648659
118MP0002210_abnormal_sex_determination0.87165927
119MP0000049_abnormal_middle_ear0.87028863
120MP0002109_abnormal_limb_morphology0.86405516
121MP0002733_abnormal_thermal_nociception0.86192485
122MP0006072_abnormal_retinal_apoptosis0.85891676
123MP0002085_abnormal_embryonic_tissue0.85026668
124MP0002009_preneoplasia0.84922761
125MP0002925_abnormal_cardiovascular_devel0.84299585
126MP0002086_abnormal_extraembryonic_tissu0.82906577
127MP0002136_abnormal_kidney_physiology0.82698215
128MP0003137_abnormal_impulse_conducting0.79660960
129MP0002933_joint_inflammation0.79587597
130MP0000747_muscle_weakness0.79556819
131MP0005253_abnormal_eye_physiology0.79097357
132MP0001929_abnormal_gametogenesis0.78425043
133MP0004085_abnormal_heartbeat0.78414805
134MP0001485_abnormal_pinna_reflex0.78299837
135MP0008932_abnormal_embryonic_tissue0.77834596
136MP0003635_abnormal_synaptic_transmissio0.76201508
137MP0003631_nervous_system_phenotype0.76172816
138MP0000427_abnormal_hair_cycle0.76025394
139MP0000538_abnormal_urinary_bladder0.75514359
140MP0002938_white_spotting0.74936969
141MP0010678_abnormal_skin_adnexa0.74781396
142MP0002876_abnormal_thyroid_physiology0.73292401
143MP0001697_abnormal_embryo_size0.72588110
144MP0009384_cardiac_valve_regurgitation0.72553312
145MP0004036_abnormal_muscle_relaxation0.72549458
146MP0010094_abnormal_chromosome_stability0.72447993
147MP0004484_altered_response_of0.71898697
148MP0002735_abnormal_chemical_nociception0.71750471
149MP0000609_abnormal_liver_physiology0.71500969
150MP0002132_abnormal_respiratory_system0.70549736
151MP0003633_abnormal_nervous_system0.70542975
152MP0001324_abnormal_eye_pigmentation0.70312105
153MP0005451_abnormal_body_composition0.70125041
154MP0000653_abnormal_sex_gland0.70111536
155MP0002282_abnormal_trachea_morphology0.69845970
156MP0010368_abnormal_lymphatic_system0.68977754
157MP0005319_abnormal_enzyme/_coenzyme0.67155415
158MP0004197_abnormal_fetal_growth/weight/0.67047525
159MP0005395_other_phenotype0.65481692
160MP0000470_abnormal_stomach_morphology0.65347322
161MP0001119_abnormal_female_reproductive0.65151483
162MP0003121_genomic_imprinting0.64891055
163MP0005623_abnormal_meninges_morphology0.64205346
164MP0000462_abnormal_digestive_system0.64186086
165MP0005195_abnormal_posterior_eye0.62880778
166MP0000432_abnormal_head_morphology0.62869799
167MP0002295_abnormal_pulmonary_circulatio0.61928548
168MP0001145_abnormal_male_reproductive0.61740403
169MP0005391_vision/eye_phenotype0.61700875
170MP0001348_abnormal_lacrimal_gland0.61638289
171MP0002272_abnormal_nervous_system0.61365397
172MP0000751_myopathy0.60604882
173MP0004272_abnormal_basement_membrane0.60197660
174MP0003634_abnormal_glial_cell0.59739843
175MP0001666_abnormal_nutrient_absorption0.59585029
176MP0005334_abnormal_fat_pad0.59242128
177MP0009840_abnormal_foam_cell0.58474997
178MP0002971_abnormal_brown_adipose0.58135245
179MP0000249_abnormal_blood_vessel0.57948249
180MP0001970_abnormal_pain_threshold0.57704967
181MP0005535_abnormal_body_temperature0.57288700
182MP0005670_abnormal_white_adipose0.54163137
183MP0002653_abnormal_ependyma_morphology0.53902106
184MP0001177_atelectasis0.52793628
185MP0002064_seizures0.52325372
186MP0001486_abnormal_startle_reflex0.50938558
187MP0003656_abnormal_erythrocyte_physiolo0.50255139
188MP0000013_abnormal_adipose_tissue0.48879460
189MP0009053_abnormal_anal_canal0.48743692

Predicted human phenotypes

RankGene SetZ-score
1Myocardial infarction (HP:0001658)5.44102225
2Hypophosphatemic rickets (HP:0004912)5.10976057
3Vascular calcification (HP:0004934)4.86196520
4Potter facies (HP:0002009)4.86128931
5Facial shape deformation (HP:0011334)4.86128931
6Complement deficiency (HP:0004431)4.60764180
7Double outlet right ventricle (HP:0001719)4.53977630
8Congenital malformation of the right heart (HP:0011723)4.53977630
9Cardiovascular calcification (HP:0011915)4.52794025
10Neurofibrillary tangles (HP:0002185)4.44050346
11Intestinal atresia (HP:0011100)4.39687050
12Abnormality of the parathyroid morphology (HP:0011766)4.38847506
13Cerebral inclusion bodies (HP:0100314)4.25408344
14Abdominal situs inversus (HP:0003363)4.08459926
15Abnormality of abdominal situs (HP:0011620)4.08459926
16Anal stenosis (HP:0002025)3.93111258
17Malnutrition (HP:0004395)3.88511150
18Choroideremia (HP:0001139)3.76773238
19Oligodactyly (hands) (HP:0001180)3.73121417
20Esophageal atresia (HP:0002032)3.66427710
21Absent radius (HP:0003974)3.55134091
22Neoplasm of the heart (HP:0100544)3.46365150
23Widely patent fontanelles and sutures (HP:0004492)3.45225992
24Aplasia/Hypoplasia of the uvula (HP:0010293)3.35456924
25Abnormality of complement system (HP:0005339)3.34846548
26Absent forearm bone (HP:0003953)3.32702698
27Aplasia involving forearm bones (HP:0009822)3.32702698
28Labial hypoplasia (HP:0000066)3.31623268
29Infantile muscular hypotonia (HP:0008947)3.31214814
30Aqueductal stenosis (HP:0002410)3.30636710
31Mixed hearing impairment (HP:0000410)3.26582558
32Abnormality of chromosome stability (HP:0003220)3.25456771
33Recurrent gram-negative bacterial infections (HP:0005420)3.22086401
34Genetic anticipation (HP:0003743)3.19956011
35Abnormality of the nasal septum (HP:0000419)3.18702149
36Rickets (HP:0002748)3.17180951
37Xanthomatosis (HP:0000991)3.16540417
38Supranuclear gaze palsy (HP:0000605)3.12591260
39Intention tremor (HP:0002080)3.10327566
40Agitation (HP:0000713)3.04898587
41Abnormal pancreas size (HP:0012094)3.02104077
42Hypoplastic female external genitalia (HP:0012815)2.99410286
43Choreoathetosis (HP:0001266)2.99049521
44Deep venous thrombosis (HP:0002625)2.98575076
45Bifid tongue (HP:0010297)2.94653982
46Progressive inability to walk (HP:0002505)2.94364708
47Gastrointestinal atresia (HP:0002589)2.86480356
48Abnormality of the columella (HP:0009929)2.76949643
49Anophthalmia (HP:0000528)2.76607562
50Hypoplastic labia majora (HP:0000059)2.75038074
51Hemiplegia (HP:0002301)2.73307022
52Ketoacidosis (HP:0001993)2.64988037
53Abnormality of the ileum (HP:0001549)2.59240190
54Meckel diverticulum (HP:0002245)2.57956323
55Clubbing of toes (HP:0100760)2.52896878
56Abnormality of the fovea (HP:0000493)2.52448146
57Chromsome breakage (HP:0040012)2.47161026
58Abnormality of the labia majora (HP:0012881)2.46273307
59Preaxial foot polydactyly (HP:0001841)2.46033120
60Triphalangeal thumb (HP:0001199)2.45848798
61Polar cataract (HP:0010696)2.43977440
62Ketosis (HP:0001946)2.43314199
63Difficulty running (HP:0009046)2.41290436
64Abnormality of the duodenum (HP:0002246)2.40487201
65Gonadal dysgenesis (HP:0000133)2.40311785
66Intrahepatic cholestasis (HP:0001406)2.39958262
67Septo-optic dysplasia (HP:0100842)2.39052542
68Vacuolated lymphocytes (HP:0001922)2.38737475
69Amyloidosis (HP:0011034)2.38344490
70Stenosis of the external auditory canal (HP:0000402)2.38029779
71Peripheral hypomyelination (HP:0007182)2.36116772
72Hypopigmentation of the fundus (HP:0007894)2.34371726
73Gout (HP:0001997)2.34354265
74Hemorrhage of the eye (HP:0011885)2.33060801
75Abnormality of the aortic arch (HP:0012303)2.32972715
76Short hallux (HP:0010109)2.31273593
77Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.30439048
78Short 1st metacarpal (HP:0010034)2.30089454
79Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.30089454
80Acanthosis nigricans (HP:0000956)2.29799361
81Laryngomalacia (HP:0001601)2.29721437
82Short humerus (HP:0005792)2.27231351
83Abnormality of the labia (HP:0000058)2.26708584
84Skin nodule (HP:0200036)2.25718658
85Hyporeflexia of lower limbs (HP:0002600)2.25378934
86Abnormal hemoglobin (HP:0011902)2.25039558
87Cupped ear (HP:0000378)2.25034813
88Abnormality of aromatic amino acid family metabolism (HP:0004338)2.24404960
89Oligodactyly (HP:0012165)2.24359616
90Ulnar claw (HP:0001178)2.20479806
91Aplasia/Hypoplasia of the hallux (HP:0008362)2.19847088
92Aplasia/Hypoplasia of the tibia (HP:0005772)2.19376109
93Testicular atrophy (HP:0000029)2.18796986
94Short middle phalanx of the 5th finger (HP:0004220)2.18696703
95Abnormality of purine metabolism (HP:0004352)2.18514235
96Hyperglycinuria (HP:0003108)2.17404516
97Duplicated collecting system (HP:0000081)2.17356558
98Horseshoe kidney (HP:0000085)2.16865834
99Osteomalacia (HP:0002749)2.16672910
100Hepatoblastoma (HP:0002884)2.15548013
101Abnormality of the preputium (HP:0100587)2.14578963
102Aplasia/hypoplasia of the humerus (HP:0006507)2.14053923
103Dynein arm defect of respiratory motile cilia (HP:0012255)2.12919696
104Absent/shortened dynein arms (HP:0200106)2.12919696
105Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12821731
106Disproportionate short-trunk short stature (HP:0003521)2.11400560
107Chin dimple (HP:0010751)2.11261488
108Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.10753031
109Thin bony cortex (HP:0002753)2.09644933
110Abnormal umbilical cord blood vessels (HP:0011403)2.09563871
111Single umbilical artery (HP:0001195)2.09563871
112Abnormality of the fetal cardiovascular system (HP:0010948)2.09563871
113Hyperparathyroidism (HP:0000843)2.07876381
114Hyperlipoproteinemia (HP:0010980)2.07805704
115Abnormal rod and cone electroretinograms (HP:0008323)2.07589992
116Gait ataxia (HP:0002066)2.07200158
117Spastic diplegia (HP:0001264)2.06947051
118Anencephaly (HP:0002323)2.06613855
119Ureteral duplication (HP:0000073)2.05878465
120Epidermoid cyst (HP:0200040)2.04988322
121Right ventricular cardiomyopathy (HP:0011663)2.03846788
122Myelomeningocele (HP:0002475)2.02909284
123Preaxial hand polydactyly (HP:0001177)2.02845347
124Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.02312747
125Small intestinal stenosis (HP:0012848)2.00636074
126Duodenal stenosis (HP:0100867)2.00636074
127Wide cranial sutures (HP:0010537)1.99631560
128Focal segmental glomerulosclerosis (HP:0000097)1.97693303
129Myokymia (HP:0002411)1.97118178
130Muscle fiber splitting (HP:0003555)1.95780480
131Facial diplegia (HP:0001349)1.94486860
132Abnormality of the pubic bones (HP:0003172)1.94122670
133Increased connective tissue (HP:0009025)1.93418268
134Bifid scrotum (HP:0000048)1.93029458
135Abnormality of serine family amino acid metabolism (HP:0010894)1.92778946
136Abnormality of glycine metabolism (HP:0010895)1.92778946
137Hypertriglyceridemia (HP:0002155)1.92223742
138Gonadotropin excess (HP:0000837)1.92119320
139Abnormality of the 1st metacarpal (HP:0010009)1.91779765
140Degeneration of the lateral corticospinal tracts (HP:0002314)1.91609777
141Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91609777
142Segmental peripheral demyelination/remyelination (HP:0003481)1.90928476
143Dysostosis multiplex (HP:0000943)1.89918696
144Shawl scrotum (HP:0000049)1.89828767
145Progressive cerebellar ataxia (HP:0002073)1.89766472
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87826074
147Abnormality of the phalanges of the 5th finger (HP:0004213)1.87448039
148Abnormality of the ischium (HP:0003174)1.86777202
149Ectopia lentis (HP:0001083)1.85891117
150Abnormality of the renal collecting system (HP:0004742)1.85732955
151Hyperphosphatemia (HP:0002905)1.84321217
152Carpal bone hypoplasia (HP:0001498)1.83935444
153Bony spicule pigmentary retinopathy (HP:0007737)1.83704547
154Pili torti (HP:0003777)1.83667796
155Hypoalphalipoproteinemia (HP:0003233)1.81272428
156Systemic lupus erythematosus (HP:0002725)1.81161584
157Hypoplastic pelvis (HP:0008839)1.80919788
158Hyperammonemia (HP:0001987)1.78482283
159Restlessness (HP:0000711)1.78024460
160Prominent nose (HP:0000448)1.77610204
161Hypophosphatemia (HP:0002148)1.76814231
162Median cleft lip (HP:0000161)1.76747667
163Gastrointestinal dysmotility (HP:0002579)1.76308205
164Anal atresia (HP:0002023)1.75759880
165Rectal fistula (HP:0100590)1.75580120
166Rectovaginal fistula (HP:0000143)1.75580120
167Abnormality of monocarboxylic acid metabolism (HP:0010996)1.74317070
168Renal hypoplasia (HP:0000089)1.74104762
169Abnormal hair whorl (HP:0010721)1.73117869
170Increased CSF protein (HP:0002922)1.72495107
171Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.72216125
172Thickened helices (HP:0000391)1.72184301
173Progressive neurologic deterioration (HP:0002344)1.71876461
174Glomerulosclerosis (HP:0000096)1.70985818
175Intestinal fistula (HP:0100819)1.70360503
176Oligomenorrhea (HP:0000876)1.70353786
177Absent thumb (HP:0009777)1.70325450
178Short thumb (HP:0009778)1.70323323
179Turricephaly (HP:0000262)1.68888206
180Abnormality of the corticospinal tract (HP:0002492)1.67889180
181Abnormal auditory evoked potentials (HP:0006958)1.67782831
182Hypoplasia of the ulna (HP:0003022)1.67775102
183Choanal atresia (HP:0000453)1.67741965
184Deep palmar crease (HP:0006191)1.67422286
185Abnormality of the dental pulp (HP:0006479)1.67140085
186Psychosis (HP:0000709)1.66451554
187Tubulointerstitial fibrosis (HP:0005576)1.66165285
188Abnormality of the periventricular white matter (HP:0002518)1.65071024
189Rectal prolapse (HP:0002035)1.64220498
190Calf muscle hypertrophy (HP:0008981)1.60791723
191Abnormality of the Achilles tendon (HP:0005109)1.59401037
192Abnormality of sulfur amino acid metabolism (HP:0004339)1.58846309
193Prominent forehead (HP:0011220)1.58615528
194Abnormality of transition element cation homeostasis (HP:0011030)1.57281562
195Pancreatitis (HP:0001733)1.54317829
196Back pain (HP:0003418)1.54293048
197Abnormality of secondary sexual hair (HP:0009888)1.53499761
198Abnormality of the axillary hair (HP:0100134)1.53499761
199Hyperglycinemia (HP:0002154)1.53448760
200Loss of speech (HP:0002371)1.53408720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.35362724
2ERBB43.87410055
3MST43.74328920
4BMPR1B3.62121140
5TRIM283.57482763
6ERN13.21382782
7LMTK23.18593318
8MAP3K42.98051000
9EPHB12.83667180
10TNIK2.64567291
11WNK32.64118115
12SIK12.57093285
13PINK12.49769071
14PBK2.40079802
15LRRK22.39778080
16FGFR22.36388857
17PKN22.33094208
18FER2.22080288
19PDGFRA2.19254745
20TGFBR12.06897880
21TRIB32.05225611
22MKNK21.96623138
23SIK31.95401108
24FGFR41.95338443
25TAOK31.88565010
26STK391.87054485
27NUAK11.83193840
28WNK41.79965286
29MAP3K91.79804824
30PRKD31.78212530
31PDK21.77101490
32GRK11.62304273
33MAP2K71.61422909
34STK241.60638784
35MELK1.60138804
36MAP3K21.52107097
37STK31.50382602
38MAP4K21.48817326
39PTK61.48383669
40EIF2AK31.45701192
41PLK41.44565850
42NTRK11.42125129
43TNK21.39500640
44EPHA21.36843109
45TTN1.35135892
46MKNK11.34293889
47RET1.32892187
48NTRK31.32645048
49TYRO31.32104422
50PTK2B1.28856883
51RIPK41.27487219
52STK38L1.27234766
53PAK31.23676232
54MAP2K41.20300114
55MYLK1.19553039
56OBSCN1.18227018
57PTK21.17913540
58BRD41.17544050
59FRK1.14643166
60INSR1.14391159
61ZAK1.13636605
62PNCK1.09086925
63STK101.09008500
64PAK61.07409926
65NLK1.07129631
66BRSK21.05769253
67MAP3K121.05630796
68PRKCH1.04559363
69CDK191.02120967
70KSR21.01905514
71TESK11.00941073
72FGFR31.00223758
73PLK20.98834630
74EPHB20.97580904
75NEK60.97015662
76SCYL20.95454063
77BCKDK0.94475760
78LATS20.90532341
79MAP3K70.89226658
80DMPK0.89205043
81ADRBK20.84814178
82ALK0.82808842
83CDK50.82414396
84PAK20.82061981
85ICK0.78950856
86EPHA40.76978596
87CDC42BPA0.76292340
88PAK40.75375471
89MAP2K10.74767205
90MAP3K60.74758689
91PDK30.74234147
92PDK40.74234147
93NTRK20.74128203
94ADRBK10.74011610
95MINK10.73364499
96CAMK1G0.70054378
97SIK20.69182696
98PHKG20.68938657
99PHKG10.68938657
100NEK20.68098308
101CDK30.67969154
102PRKCG0.67953936
103GSK3A0.66848444
104FGFR10.65785038
105WNK10.65567164
106BCR0.64897469
107ROCK20.64505483
108DDR20.63995851
109JAK20.63196002
110LATS10.62001636
111SRC0.61970926
112EIF2AK20.61928616
113DAPK20.61220044
114FYN0.60464254
115STK380.60041258
116UHMK10.59733032
117PRKD10.59301008
118PDGFRB0.59108058
119BRSK10.58591284
120ERBB30.58059330
121CASK0.57332054
122CDK60.56694402
123PRKCZ0.56157449
124INSRR0.56033856
125PRKACG0.55926292
126MAP3K50.55376064
127EEF2K0.55166634
128MARK30.53639549
129PRKCE0.52649958
130FLT30.52506557
131ARAF0.52172310
132CSNK1E0.52009694
133FES0.51437115
134MET0.51379009
135ERBB20.50181465
136EPHA30.49001370
137MARK10.48660995
138AKT30.47410280
139GRK50.47088742
140MAP3K130.46507514
141PRKCQ0.46222943
142EGFR0.46124258
143TGFBR20.45113833
144JAK10.45015453
145CDK120.44489134
146PIK3CG0.44445162
147HIPK20.41718912
148CSK0.39881208
149CAMK1D0.39831680
150ATM0.39593844
151PDK10.39044574
152IGF1R0.39032024
153CDK90.37787708
154WEE10.37547869
155CAMK40.36505654
156MAPK70.34750861
157PRKG10.34719020
158TXK0.33018762
159MAPK130.32949166
160PLK30.32466423
161TEC0.30885964
162ATR0.30760661
163TIE10.30479559
164SGK20.30205444
165CHEK20.28908356
166CHEK10.27942221
167CAMK10.26499021
168PLK10.24218315
169CDC70.24115139
170KIT0.23035008
171CSNK1D0.22044397
172MAPK10.21844581

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.19857765
2Glutathione metabolism_Homo sapiens_hsa004804.28917765
3Basal transcription factors_Homo sapiens_hsa030223.79559523
4Tryptophan metabolism_Homo sapiens_hsa003803.51090892
5Arachidonic acid metabolism_Homo sapiens_hsa005903.46740125
6Thyroid hormone synthesis_Homo sapiens_hsa049183.38795503
7African trypanosomiasis_Homo sapiens_hsa051433.31376127
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.04284524
9Fanconi anemia pathway_Homo sapiens_hsa034602.79378039
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.66557997
11TGF-beta signaling pathway_Homo sapiens_hsa043502.64728325
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39211428
13Homologous recombination_Homo sapiens_hsa034402.21947051
14Wnt signaling pathway_Homo sapiens_hsa043102.19367362
15Sulfur metabolism_Homo sapiens_hsa009202.02032467
16Fatty acid degradation_Homo sapiens_hsa000711.99976527
17Fatty acid metabolism_Homo sapiens_hsa012121.93880696
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88071848
19Phototransduction_Homo sapiens_hsa047441.84796995
20Arginine biosynthesis_Homo sapiens_hsa002201.84041130
21Basal cell carcinoma_Homo sapiens_hsa052171.81043569
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76053771
23RNA degradation_Homo sapiens_hsa030181.67662221
24Oocyte meiosis_Homo sapiens_hsa041141.61856091
25PPAR signaling pathway_Homo sapiens_hsa033201.60503106
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54154438
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54058086
28Dorso-ventral axis formation_Homo sapiens_hsa043201.48252001
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47247061
30Ovarian steroidogenesis_Homo sapiens_hsa049131.46440579
31Hedgehog signaling pathway_Homo sapiens_hsa043401.44569362
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43973692
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42610283
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42183491
35Calcium signaling pathway_Homo sapiens_hsa040201.38880513
36Salivary secretion_Homo sapiens_hsa049701.37832413
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36006664
38Hippo signaling pathway_Homo sapiens_hsa043901.35359984
39Adherens junction_Homo sapiens_hsa045201.31960956
40Lysine degradation_Homo sapiens_hsa003101.31881361
41Glycerolipid metabolism_Homo sapiens_hsa005611.28471732
42Non-homologous end-joining_Homo sapiens_hsa034501.28207973
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27494821
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25214706
45Cell cycle_Homo sapiens_hsa041101.21892570
46mRNA surveillance pathway_Homo sapiens_hsa030151.18950677
47Inositol phosphate metabolism_Homo sapiens_hsa005621.18799486
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15479156
49Propanoate metabolism_Homo sapiens_hsa006401.13801549
50RNA transport_Homo sapiens_hsa030131.10441771
51Gastric acid secretion_Homo sapiens_hsa049711.10030510
52Complement and coagulation cascades_Homo sapiens_hsa046101.09762032
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.09490290
54Linoleic acid metabolism_Homo sapiens_hsa005911.07990957
55Renin secretion_Homo sapiens_hsa049241.07649053
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06738483
57Steroid biosynthesis_Homo sapiens_hsa001001.05003118
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03361277
59p53 signaling pathway_Homo sapiens_hsa041151.02474165
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01085333
61Circadian rhythm_Homo sapiens_hsa047101.00973595
62Butanoate metabolism_Homo sapiens_hsa006500.98106285
63Bile secretion_Homo sapiens_hsa049760.97632632
64Lysosome_Homo sapiens_hsa041420.96988937
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95470135
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93492108
67Serotonergic synapse_Homo sapiens_hsa047260.93381622
68Phenylalanine metabolism_Homo sapiens_hsa003600.92965300
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91914111
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90507212
71Pyruvate metabolism_Homo sapiens_hsa006200.90118114
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89914026
73GABAergic synapse_Homo sapiens_hsa047270.86951829
74beta-Alanine metabolism_Homo sapiens_hsa004100.85980068
75Ether lipid metabolism_Homo sapiens_hsa005650.85692930
76Taste transduction_Homo sapiens_hsa047420.85637444
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85271480
78Caffeine metabolism_Homo sapiens_hsa002320.85250400
79Fat digestion and absorption_Homo sapiens_hsa049750.85092365
80Long-term potentiation_Homo sapiens_hsa047200.82512193
81Starch and sucrose metabolism_Homo sapiens_hsa005000.79574260
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.74501793
83Estrogen signaling pathway_Homo sapiens_hsa049150.74450068
84RNA polymerase_Homo sapiens_hsa030200.72634687
85Histidine metabolism_Homo sapiens_hsa003400.72618160
86Collecting duct acid secretion_Homo sapiens_hsa049660.72044986
87Vibrio cholerae infection_Homo sapiens_hsa051100.71936299
88Circadian entrainment_Homo sapiens_hsa047130.70626162
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70551035
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69625999
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69377785
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68952749
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67413462
94Prion diseases_Homo sapiens_hsa050200.64673842
95Arginine and proline metabolism_Homo sapiens_hsa003300.64594272
96Fatty acid elongation_Homo sapiens_hsa000620.63767303
97Selenocompound metabolism_Homo sapiens_hsa004500.63718244
98Tight junction_Homo sapiens_hsa045300.61309653
99Retinol metabolism_Homo sapiens_hsa008300.60420591
100Fatty acid biosynthesis_Homo sapiens_hsa000610.59276308
101Staphylococcus aureus infection_Homo sapiens_hsa051500.58524834
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58459885
103FoxO signaling pathway_Homo sapiens_hsa040680.56801248
104Choline metabolism in cancer_Homo sapiens_hsa052310.56355455
105Amphetamine addiction_Homo sapiens_hsa050310.55833324
106Synaptic vesicle cycle_Homo sapiens_hsa047210.55825265
107Carbon metabolism_Homo sapiens_hsa012000.55800087
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54941972
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.54646530
110ECM-receptor interaction_Homo sapiens_hsa045120.54345672
111Glutamatergic synapse_Homo sapiens_hsa047240.49725199
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49466209
113Biosynthesis of amino acids_Homo sapiens_hsa012300.48863024
114Tyrosine metabolism_Homo sapiens_hsa003500.48168867
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.47215192
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.45122848
117Colorectal cancer_Homo sapiens_hsa052100.43686741
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43164839
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43016472
120MicroRNAs in cancer_Homo sapiens_hsa052060.42608632
121Proteoglycans in cancer_Homo sapiens_hsa052050.42597048
122Folate biosynthesis_Homo sapiens_hsa007900.42139721
123Peroxisome_Homo sapiens_hsa041460.42122711
124Oxytocin signaling pathway_Homo sapiens_hsa049210.41539135
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41473872
126Insulin secretion_Homo sapiens_hsa049110.41306523
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.41182285
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40734675
129Dopaminergic synapse_Homo sapiens_hsa047280.39589890
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38793631
131Chemical carcinogenesis_Homo sapiens_hsa052040.38751223
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38286088
133Morphine addiction_Homo sapiens_hsa050320.38014317
134Prostate cancer_Homo sapiens_hsa052150.37903827
135Pathways in cancer_Homo sapiens_hsa052000.37645948
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37550791
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37425692
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.37031155
139ABC transporters_Homo sapiens_hsa020100.35783665
140GnRH signaling pathway_Homo sapiens_hsa049120.35016472
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34548481
142Glucagon signaling pathway_Homo sapiens_hsa049220.34486743
143N-Glycan biosynthesis_Homo sapiens_hsa005100.33947401
144Vitamin B6 metabolism_Homo sapiens_hsa007500.33866808
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33576575
146Melanoma_Homo sapiens_hsa052180.33335131
147Glioma_Homo sapiens_hsa052140.33010524
148Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32995335
149SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32979541
150Cholinergic synapse_Homo sapiens_hsa047250.32362192
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32025921
152Mismatch repair_Homo sapiens_hsa034300.31578941
153Cocaine addiction_Homo sapiens_hsa050300.31496133
154cAMP signaling pathway_Homo sapiens_hsa040240.30120639
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.29845862
156Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29627255
157Olfactory transduction_Homo sapiens_hsa047400.29582027
158cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29220295
159Melanogenesis_Homo sapiens_hsa049160.28584289
160Purine metabolism_Homo sapiens_hsa002300.27289250
161Insulin resistance_Homo sapiens_hsa049310.25518489

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