OVOL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.93804512
2hemidesmosome assembly (GO:0031581)9.30501184
3intermediate filament organization (GO:0045109)7.75370946
4positive regulation of cellular amide metabolic process (GO:0034250)7.66443458
5branching involved in labyrinthine layer morphogenesis (GO:0060670)7.54555186
6keratinocyte differentiation (GO:0030216)7.03358423
7bundle of His cell to Purkinje myocyte communication (GO:0086069)6.70700621
8multicellular organismal water homeostasis (GO:0050891)6.65058781
9peptide cross-linking (GO:0018149)5.98161952
10keratinocyte development (GO:0003334)5.94388693
11epidermis development (GO:0008544)5.78853030
12interferon-gamma secretion (GO:0072643)5.75413926
13positive regulation of interleukin-8 secretion (GO:2000484)5.68153858
14keratinocyte proliferation (GO:0043616)5.66791616
15water homeostasis (GO:0030104)5.66069407
16intestinal epithelial cell development (GO:0060576)5.54193736
17* epidermal cell differentiation (GO:0009913)5.37042541
18positive regulation of p38MAPK cascade (GO:1900745)5.31747667
19skin morphogenesis (GO:0043589)5.28831593
20virion attachment to host cell (GO:0019062)5.10426772
21adhesion of symbiont to host cell (GO:0044650)5.10426772
22positive regulation of glomerulus development (GO:0090193)5.07368016
23sphingoid metabolic process (GO:0046519)4.96471300
24ectoderm development (GO:0007398)4.91319363
25positive regulation of humoral immune response (GO:0002922)4.72447828
26intermediate filament cytoskeleton organization (GO:0045104)4.66696375
27intermediate filament-based process (GO:0045103)4.56040288
28antimicrobial humoral response (GO:0019730)4.53550864
29sphingosine metabolic process (GO:0006670)4.50352964
30defense response to Gram-negative bacterium (GO:0050829)4.43154757
31diol metabolic process (GO:0034311)4.35992395
32positive regulation of keratinocyte differentiation (GO:0045618)4.35391820
33negative regulation of keratinocyte proliferation (GO:0010839)4.33994737
34regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.20415184
35positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.20415184
36regulation of cardioblast differentiation (GO:0051890)4.19386290
37atrioventricular valve morphogenesis (GO:0003181)4.13590290
38phosphatidylserine acyl-chain remodeling (GO:0036150)3.98227089
39adhesion of symbiont to host (GO:0044406)3.97552971
40regulation of cellular amide metabolic process (GO:0034248)3.92129504
41regulation of p38MAPK cascade (GO:1900744)3.89468167
42activation of MAPKKK activity (GO:0000185)3.84004026
43regulation of ruffle assembly (GO:1900027)3.81448725
44phospholipid efflux (GO:0033700)3.81007694
45phosphatidylinositol acyl-chain remodeling (GO:0036149)3.80043988
46cell wall macromolecule catabolic process (GO:0016998)3.73525420
47cell wall macromolecule metabolic process (GO:0044036)3.73525420
48negative regulation of cell fate specification (GO:0009996)3.73408434
49positive regulation of epidermis development (GO:0045684)3.66034966
50antibacterial humoral response (GO:0019731)3.63362361
51defense response to fungus (GO:0050832)3.62429451
52regulation of interleukin-8 secretion (GO:2000482)3.61323798
53viral transcription (GO:0019083)3.59659763
54L-alpha-amino acid transmembrane transport (GO:1902475)3.59587322
55maturation of SSU-rRNA (GO:0030490)3.58158200
56regulation of glomerulus development (GO:0090192)3.57401261
57nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.55989628
58hair follicle morphogenesis (GO:0031069)3.55003367
59cell differentiation involved in embryonic placenta development (GO:0060706)3.50808694
60positive regulation of epidermal cell differentiation (GO:0045606)3.44607601
61translational termination (GO:0006415)3.41554594
62regulation of chemokine secretion (GO:0090196)3.33743982
63regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.33069039
64phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.32597970
65regulation of keratinocyte differentiation (GO:0045616)3.31673926
66pyrimidine-containing compound transmembrane transport (GO:0072531)3.29364793
67polarized epithelial cell differentiation (GO:0030859)3.26629623
68ventricular cardiac muscle cell action potential (GO:0086005)3.25210934
69positive regulation of Cdc42 GTPase activity (GO:0043089)3.24708866
70sphingomyelin metabolic process (GO:0006684)3.24476153
71ribosomal small subunit biogenesis (GO:0042274)3.22439235
72regulation of keratinocyte proliferation (GO:0010837)3.22163218
73negative regulation of cell fate commitment (GO:0010454)3.22028033
74lung-associated mesenchyme development (GO:0060484)3.20580936
75positive regulation of T-helper 1 type immune response (GO:0002827)3.20214356
76regulation of epidermis development (GO:0045682)3.18426519
77chemical homeostasis within a tissue (GO:0048875)3.18337664
78cellular protein complex localization (GO:0034629)3.17172265
79intestinal absorption (GO:0050892)3.10761823
80lipoxygenase pathway (GO:0019372)3.10395408
81intestinal cholesterol absorption (GO:0030299)3.08485739
82calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.06255211
83basic amino acid transport (GO:0015802)3.04709008
84positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.03254493
85phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.00242936
86regulation of cholesterol homeostasis (GO:2000188)2.99355695
87epithelial cell-cell adhesion (GO:0090136)2.96905564
88dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.95918705
89protein complex localization (GO:0031503)2.94656222
90eyelid development in camera-type eye (GO:0061029)2.94455838
91mammary gland epithelial cell proliferation (GO:0033598)2.94130190
92cardiac right ventricle morphogenesis (GO:0003215)2.93583876
93regulation of epidermal cell differentiation (GO:0045604)2.93096643
94cytoskeletal anchoring at plasma membrane (GO:0007016)2.90168212
95negative regulation of epidermal cell differentiation (GO:0045605)2.90128132
96regulation of cell proliferation involved in kidney development (GO:1901722)2.89283399
97positive regulation of hair follicle development (GO:0051798)2.88570665
98positive regulation of hair cycle (GO:0042635)2.88570665
99epithelium development (GO:0060429)2.87479558
100regulation of bile acid biosynthetic process (GO:0070857)2.87302503
101early endosome to late endosome transport (GO:0045022)2.86908934
102bile acid and bile salt transport (GO:0015721)2.85677652
103negative regulation of kidney development (GO:0090185)2.85080140
104negative regulation of epidermis development (GO:0045683)2.83360699
105cell-substrate junction assembly (GO:0007044)2.83064899
106phosphatidylserine metabolic process (GO:0006658)2.81666255
107alditol phosphate metabolic process (GO:0052646)2.80984652
108tight junction assembly (GO:0070830)2.80601743
109ER overload response (GO:0006983)2.80057730
110hair cycle process (GO:0022405)2.79929237
111molting cycle process (GO:0022404)2.79929237
112positive regulation of cholesterol efflux (GO:0010875)2.79759708
113regulation of hair follicle development (GO:0051797)2.79626410
114translational elongation (GO:0006414)2.79016531
115cellular response to arsenic-containing substance (GO:0071243)2.78926080
116fatty acid elongation (GO:0030497)2.78577610
117C21-steroid hormone biosynthetic process (GO:0006700)2.77430397
118negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.76533837
119positive regulation of transforming growth factor beta production (GO:0071636)2.76505930
120embryonic process involved in female pregnancy (GO:0060136)2.76118081
121branching involved in mammary gland duct morphogenesis (GO:0060444)2.74281805
122response to phenylpropanoid (GO:0080184)2.73790573
123hair cell differentiation (GO:0035315)2.73523644
124citrulline biosynthetic process (GO:0019240)2.72289017
125phosphatidylcholine acyl-chain remodeling (GO:0036151)2.70678108
126cellular protein complex disassembly (GO:0043624)2.69882523
127viral life cycle (GO:0019058)2.69453930
128modified amino acid transport (GO:0072337)2.69199749
129dendritic cell migration (GO:0036336)2.68933664
130skin development (GO:0043588)2.68665265
131epithelial cell maturation (GO:0002070)2.68362153
132ribosomal large subunit biogenesis (GO:0042273)2.66477571
133regulation of transforming growth factor beta1 production (GO:0032908)2.65774076
134translational initiation (GO:0006413)2.61490992
135wound healing, spreading of epidermal cells (GO:0035313)2.58945920
136nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.54478031
137surfactant homeostasis (GO:0043129)2.53937367
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.53505574
139regulation of phospholipase A2 activity (GO:0032429)2.49146309
140protein targeting to ER (GO:0045047)2.48786084
141trophectodermal cell differentiation (GO:0001829)2.48620312
142negative regulation of stress fiber assembly (GO:0051497)2.47437337
143detection of bacterium (GO:0016045)2.44676398
144cotranslational protein targeting to membrane (GO:0006613)2.44251711
145ribosomal small subunit assembly (GO:0000028)2.44170834
146regulation of hair cycle (GO:0042634)2.41414055
147hair cycle (GO:0042633)14.2113872
148molting cycle (GO:0042303)14.2113872
149desmosome organization (GO:0002934)13.2379071
150keratinization (GO:0031424)12.3347375
151establishment of skin barrier (GO:0061436)10.5690331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.60645885
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.56501951
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.97008123
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.94496327
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.79539251
6ZNF263_19887448_ChIP-Seq_K562_Human2.57350940
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.33924932
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.31135876
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.31075042
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.25148613
11SOX9_24532713_ChIP-Seq_HFSC_Mouse2.16432580
12TP63_17297297_ChIP-ChIP_HaCaT_Human16.2879118
13* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.95315537
14* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.95315537
15FOXO3_23340844_ChIP-Seq_DLD1_Human1.82288393
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.81391118
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70126809
18GATA4_25053715_ChIP-Seq_YYC3_Human1.69019913
19ATF3_27146783_Chip-Seq_COLON_Human1.67644695
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63744911
21ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60783480
22RUNX1_27514584_Chip-Seq_MCF-7_Human1.58239757
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58104820
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.55530037
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50134524
26GATA6_25053715_ChIP-Seq_YYC3_Human1.48143251
27BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.47602818
28* SOX2_20726797_ChIP-Seq_SW620_Human1.44964763
29KLF5_25053715_ChIP-Seq_YYC3_Human1.43156502
30* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.43059384
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35134002
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34862628
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.33301762
34* RACK7_27058665_Chip-Seq_MCF-7_Human1.33079436
35* TP63_22573176_ChIP-Seq_HFKS_Human1.32798950
36CLOCK_20551151_ChIP-Seq_293T_Human1.31665798
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30937761
38PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30873071
39AR_21909140_ChIP-Seq_LNCAP_Human1.29213405
40ELF5_23300383_ChIP-Seq_T47D_Human1.25721665
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.25433769
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24465236
43GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.20283575
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18309446
45FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14349726
46ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13829734
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12540534
48GATA3_24758297_ChIP-Seq_MCF-7_Human1.09881593
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09063524
50CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08146131
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07456248
52* ERG_20517297_ChIP-Seq_VCAP_Human1.06026841
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06021688
54TP63_23658742_ChIP-Seq_EP156T_Human1.05035981
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04587567
56UBF1/2_26484160_Chip-Seq_HMECs_Human1.04327325
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04080269
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03626296
59YY1_22570637_ChIP-Seq_MALME-3M_Human1.03412840
60CHD1_26751641_Chip-Seq_LNCaP_Human1.03265016
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01991847
62CTCF_20526341_ChIP-Seq_ESCs_Human1.01059312
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00566992
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00013002
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99441936
66RXR_22158963_ChIP-Seq_LIVER_Mouse0.99026955
67GATA6_21074721_ChIP-Seq_CACO-2_Human0.98043937
68KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97408020
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96595457
70BCOR_27268052_Chip-Seq_Bcells_Human0.96558223
71P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96489131
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95765434
73* LXR_22292898_ChIP-Seq_THP-1_Human0.94677347
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94477608
75NANOG_20526341_ChIP-Seq_ESCs_Human0.93103638
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92782081
77AHR_22903824_ChIP-Seq_MCF-7_Human0.92174353
78XRN2_22483619_ChIP-Seq_HELA_Human0.92015542
79CEBPB_22108803_ChIP-Seq_LS180_Human0.91094909
80ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90039182
81SMC4_20622854_ChIP-Seq_HELA_Human0.89045453
82CJUN_26792858_Chip-Seq_BT549_Human0.88499879
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87280875
84JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86720275
85CTCF_27219007_Chip-Seq_Bcells_Human0.86124089
86E2F1_20622854_ChIP-Seq_HELA_Human0.85752484
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85395924
88DCP1A_22483619_ChIP-Seq_HELA_Human0.84991958
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83556682
90* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83025170
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82989837
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82839638
93ELK3_25401928_ChIP-Seq_HUVEC_Human0.82460101
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81812425
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81098315
96FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79609067
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79476796
98SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79125852
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78980149
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78145396
101P53_21459846_ChIP-Seq_SAOS-2_Human0.77773162
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.77506630
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77237297
104CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.76790494
105JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76046371
106CSB_26484114_Chip-Seq_FIBROBLAST_Human0.75615710
107EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.74072145
108P68_20966046_ChIP-Seq_HELA_Human0.72483022
109PHF8_20622854_ChIP-Seq_HELA_Human0.72066888
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.71805310
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.71547051
112JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.71165746
113VDR_22108803_ChIP-Seq_LS180_Human0.71144670
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70146551
115TAF2_19829295_ChIP-Seq_ESCs_Human0.70123093
116EGR1_19032775_ChIP-ChIP_M12_Human0.69048458
117RXR_22108803_ChIP-Seq_LS180_Human0.68371704
118RBPJ_21746931_ChIP-Seq_IB4_Human0.68084563
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.67573510
120NANOG_18692474_ChIP-Seq_MEFs_Mouse0.66997231
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.66689817
122PPARA_22158963_ChIP-Seq_LIVER_Mouse0.66581077
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.66022469
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64289713
125MYC_19829295_ChIP-Seq_ESCs_Human0.62412283
126* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62396791
127TCF3_18692474_ChIP-Seq_MEFs_Mouse0.62173101
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.61584659
129FOXH1_21741376_ChIP-Seq_ESCs_Human0.59557062
130KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.59212190
131KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.59212190
132KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.59212190
133FOXM1_26456572_ChIP-Seq_MCF-7_Human0.59132921
134HNFA_21074721_ChIP-Seq_CACO-2_Human0.58597461
135GATA3_21867929_ChIP-Seq_TH1_Mouse0.57764267
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.57537946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier6.41497700
2MP0010234_abnormal_vibrissa_follicle5.11229131
3MP0005275_abnormal_skin_tensile4.64576050
4MP0000579_abnormal_nail_morphology4.52052179
5MP0000383_abnormal_hair_follicle4.15009424
6MP0003941_abnormal_skin_development4.09984199
7* MP0005501_abnormal_skin_physiology4.00277390
8MP0002098_abnormal_vibrissa_morphology4.00226643
9MP0010678_abnormal_skin_adnexa3.87617307
10MP0000647_abnormal_sebaceous_gland3.83863310
11MP0004381_abnormal_hair_follicle3.81304929
12MP0001216_abnormal_epidermal_layer3.32281101
13MP0002060_abnormal_skin_morphology3.20441854
14MP0002254_reproductive_system_inflammat3.12884381
15MP0000377_abnormal_hair_follicle3.05584733
16MP0003453_abnormal_keratinocyte_physiol2.97108575
17* MP0010771_integument_phenotype2.64738116
18MP0000467_abnormal_esophagus_morphology2.55150428
19MP0003705_abnormal_hypodermis_morpholog2.42727037
20MP0004947_skin_inflammation2.42552599
21MP0000427_abnormal_hair_cycle2.21201878
22MP0005451_abnormal_body_composition1.98001304
23MP0000762_abnormal_tongue_morphology1.79223651
24MP0001243_abnormal_dermal_layer1.63462086
25MP0004264_abnormal_extraembryonic_tissu1.62402815
26MP0009931_abnormal_skin_appearance1.61722268
27MP0000537_abnormal_urethra_morphology1.60038060
28MP0002234_abnormal_pharynx_morphology1.57106391
29MP0003315_abnormal_perineum_morphology1.55640160
30MP0000566_synostosis1.50837310
31* MP0000367_abnormal_coat/_hair1.48293529
32MP0010352_gastrointestinal_tract_polyps1.45534792
33MP0002009_preneoplasia1.44407939
34MP0008995_early_reproductive_senescence1.44316490
35MP0001191_abnormal_skin_condition1.43253210
36MP0009053_abnormal_anal_canal1.41032059
37MP0001666_abnormal_nutrient_absorption1.38250687
38MP0001346_abnormal_lacrimal_gland1.36236878
39MP0004019_abnormal_vitamin_homeostasis1.30714204
40MP0003566_abnormal_cell_adhesion1.28919885
41MP0009379_abnormal_foot_pigmentation1.28420451
42MP0001851_eye_inflammation1.13320660
43MP0005409_darkened_coat_color1.09684760
44MP0000003_abnormal_adipose_tissue1.09002241
45MP0001849_ear_inflammation1.00744644
46MP0000627_abnormal_mammary_gland0.97310469
47MP0005375_adipose_tissue_phenotype0.94748747
48MP0003806_abnormal_nucleotide_metabolis0.90744406
49MP0003693_abnormal_embryo_hatching0.89571656
50MP0004185_abnormal_adipocyte_glucose0.87264514
51MP0009672_abnormal_birth_weight0.83996067
52MP0005360_urolithiasis0.83121698
53MP0000462_abnormal_digestive_system0.83040597
54MP0001764_abnormal_homeostasis0.82363244
55MP0001340_abnormal_eyelid_morphology0.81723234
56MP0009384_cardiac_valve_regurgitation0.80137949
57MP0003718_maternal_effect0.79845870
58MP0004782_abnormal_surfactant_physiolog0.79579862
59MP0003136_yellow_coat_color0.75602418
60MP0005636_abnormal_mineral_homeostasis0.71868370
61MP0001881_abnormal_mammary_gland0.70750635
62MP0005076_abnormal_cell_differentiation0.70528370
63MP0005023_abnormal_wound_healing0.70518528
64MP0005377_hearing/vestibular/ear_phenot0.67051348
65MP0003878_abnormal_ear_physiology0.67051348
66MP0002282_abnormal_trachea_morphology0.66913815
67MP0005666_abnormal_adipose_tissue0.63656516
68MP0001664_abnormal_digestion0.63556619
69MP0010030_abnormal_orbit_morphology0.63448796
70MP0002277_abnormal_respiratory_mucosa0.63006639
71MP0009115_abnormal_fat_cell0.62974515
72MP0008260_abnormal_autophagy0.61284549
73MP0000538_abnormal_urinary_bladder0.61135170
74MP0004957_abnormal_blastocyst_morpholog0.60548341
75MP0003938_abnormal_ear_development0.59000995
76MP0008004_abnormal_stomach_pH0.58193541
77MP0005075_abnormal_melanosome_morpholog0.58166912
78MP0003755_abnormal_palate_morphology0.57837652
79MP0003191_abnormal_cellular_cholesterol0.57352958
80MP0002111_abnormal_tail_morphology0.57137123
81MP0001188_hyperpigmentation0.56138920
82MP0005410_abnormal_fertilization0.54945029
83MP0005408_hypopigmentation0.54601761
84MP0002249_abnormal_larynx_morphology0.54027647
85MP0001756_abnormal_urination0.53637532
86MP0005670_abnormal_white_adipose0.53303918
87MP0009333_abnormal_splenocyte_physiolog0.52086417
88MP0002086_abnormal_extraembryonic_tissu0.51959704
89MP0002736_abnormal_nociception_after0.51423427
90MP0003866_abnormal_defecation0.51274096
91MP0009840_abnormal_foam_cell0.49423909
92MP0000477_abnormal_intestine_morphology0.48437121
93MP0002095_abnormal_skin_pigmentation0.47441885
94MP0002160_abnormal_reproductive_system0.46917520
95* MP0002136_abnormal_kidney_physiology0.45483066
96MP0001873_stomach_inflammation0.45334243
97MP0000432_abnormal_head_morphology0.45029064
98MP0001727_abnormal_embryo_implantation0.44766587
99MP0009643_abnormal_urine_homeostasis0.43963022
100MP0003221_abnormal_cardiomyocyte_apopto0.43847228
101MP0003011_delayed_dark_adaptation0.43756934
102MP0002177_abnormal_outer_ear0.43749495
103MP0004272_abnormal_basement_membrane0.43732915
104MP0003329_amyloid_beta_deposits0.43538934
105MP0000470_abnormal_stomach_morphology0.43338556
106MP0002006_tumorigenesis0.42810221
107MP0000750_abnormal_muscle_regeneration0.42558492
108MP0001730_embryonic_growth_arrest0.42363764
109MP0003183_abnormal_peptide_metabolism0.42358337
110* MP0001784_abnormal_fluid_regulation0.42247936
111MP0010307_abnormal_tumor_latency0.42129012
112MP0003786_premature_aging0.41958031
113MP0002876_abnormal_thyroid_physiology0.41735913
114MP0000613_abnormal_salivary_gland0.41362452
115MP0003448_altered_tumor_morphology0.41153239
116MP0001765_abnormal_ion_homeostasis0.40954488
117MP0001542_abnormal_bone_strength0.40389282
118MP0003937_abnormal_limbs/digits/tail_de0.40294005
119MP0002233_abnormal_nose_morphology0.39192694
120MP0005187_abnormal_penis_morphology0.37751834
121MP0004147_increased_porphyrin_level0.37533603
122MP0010155_abnormal_intestine_physiology0.37147406
123MP0005085_abnormal_gallbladder_physiolo0.37138067
124MP0003950_abnormal_plasma_membrane0.37028846
125MP0003123_paternal_imprinting0.36635077
126MP0003936_abnormal_reproductive_system0.35737313
127MP0001440_abnormal_grooming_behavior0.35363647
128MP0008872_abnormal_physiological_respon0.35170232
129MP0002139_abnormal_hepatobiliary_system0.34368577
130MP0000678_abnormal_parathyroid_gland0.34012157
131MP0000490_abnormal_crypts_of0.33316052
132MP0002970_abnormal_white_adipose0.32746295
133MP0001919_abnormal_reproductive_system0.31768368
134MP0003763_abnormal_thymus_physiology0.30464369
135MP0000465_gastrointestinal_hemorrhage0.28884226
136MP0002166_altered_tumor_susceptibility0.27491222
137MP0005367_renal/urinary_system_phenotyp0.26596600
138MP0000516_abnormal_urinary_system0.26596600

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)8.38212503
2Woolly hair (HP:0002224)6.95510155
3Fragile nails (HP:0001808)6.39458270
4Onycholysis (HP:0001806)6.34714047
5Plantar hyperkeratosis (HP:0007556)6.28473073
6Abnormality of nail color (HP:0100643)6.25807408
7Increased IgE level (HP:0003212)6.13250480
8Pili torti (HP:0003777)6.07062107
9Palmoplantar hyperkeratosis (HP:0000972)5.80325696
10Milia (HP:0001056)5.61269137
11Right ventricular cardiomyopathy (HP:0011663)5.58872684
12Thick nail (HP:0001805)5.54176066
13Palmar hyperkeratosis (HP:0010765)5.49333590
14Nail dystrophy (HP:0008404)4.91132081
15Alopecia of scalp (HP:0002293)4.71928931
16Congenital ichthyosiform erythroderma (HP:0007431)4.62131484
17Erythroderma (HP:0001019)3.96847144
18Abnormal blistering of the skin (HP:0008066)3.95352692
19Brittle hair (HP:0002299)3.94419462
20Parakeratosis (HP:0001036)3.86041077
21Sparse eyelashes (HP:0000653)3.85050809
22Erythema (HP:0010783)3.81275059
23Lip pit (HP:0100267)3.74125522
24Abnormal hair laboratory examination (HP:0003328)3.70437079
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.57288458
26Abnormality of the frontal sinuses (HP:0002687)3.34386544
27Ridged nail (HP:0001807)3.33169580
28Malnutrition (HP:0004395)3.32131209
29Curly hair (HP:0002212)3.22242985
30Abnormality of the salivary glands (HP:0010286)3.04200040
31Natal tooth (HP:0000695)2.89806348
32Abnormality of dental color (HP:0011073)2.85922088
33Atrophic scars (HP:0001075)2.85619108
34Abnormality of hair growth rate (HP:0011363)2.84539080
35Slow-growing hair (HP:0002217)2.84539080
36Concave nail (HP:0001598)2.82877932
37Hypohidrosis (HP:0000966)2.82497909
38Oral leukoplakia (HP:0002745)2.80826208
39Corneal erosion (HP:0200020)2.80466356
40Advanced eruption of teeth (HP:0006288)2.71942566
41Ectropion (HP:0000656)2.71451647
42Ventricular fibrillation (HP:0001663)2.68311217
43Congenital, generalized hypertrichosis (HP:0004540)2.62949327
44Ventricular tachycardia (HP:0004756)2.61918423
45Villous atrophy (HP:0011473)2.57146453
46Abnormality of small intestinal villus morphology (HP:0011472)2.57146453
47Palmoplantar keratoderma (HP:0000982)2.55851109
48Conjunctival hamartoma (HP:0100780)2.49901241
49Abnormality of monocarboxylic acid metabolism (HP:0010996)2.49846663
50Abnormality of the distal phalanges of the toes (HP:0010182)2.49233462
51Aplasia cutis congenita (HP:0001057)2.44193933
52Follicular hyperkeratosis (HP:0007502)2.41985885
53Amelogenesis imperfecta (HP:0000705)2.40848227
54Abnormality of secondary sexual hair (HP:0009888)2.32187419
55Abnormality of the axillary hair (HP:0100134)2.32187419
56Blepharitis (HP:0000498)2.29048660
57Popliteal pterygium (HP:0009756)2.26510444
58Reticulocytopenia (HP:0001896)2.26336323
59Pruritus (HP:0000989)2.21551579
60Gangrene (HP:0100758)2.21399186
61Pustule (HP:0200039)2.18573313
62Premature ovarian failure (HP:0008209)2.15332042
63Ileus (HP:0002595)2.15137196
64Abnormality of the neuromuscular junction (HP:0003398)2.13534717
65Fatigable weakness (HP:0003473)2.13534717
66Trismus (HP:0000211)2.11601697
67Septate vagina (HP:0001153)2.10049875
68Pterygium (HP:0001059)2.09556782
69Dehydration (HP:0001944)2.06846754
70Carious teeth (HP:0000670)2.06715868
71Hypoplasia of dental enamel (HP:0006297)2.05137934
72Laryngomalacia (HP:0001601)2.05080115
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03530291
74Cone-rod dystrophy (HP:0000548)2.02759310
75Hyperactive renin-angiotensin system (HP:0000841)2.02600083
76Acanthosis nigricans (HP:0000956)2.02484104
77Distal lower limb muscle weakness (HP:0009053)2.02152474
78Seborrheic dermatitis (HP:0001051)1.99795999
79Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.99788840
80Sparse scalp hair (HP:0002209)1.98015182
81Dry hair (HP:0011359)1.97662627
82Absent eyebrow (HP:0002223)1.96424920
83Areflexia of lower limbs (HP:0002522)1.95841936
84Ureteral duplication (HP:0000073)1.88722557
85Hyporeflexia of lower limbs (HP:0002600)1.87473508
86Absent eyelashes (HP:0000561)1.85115579
87Anonychia (HP:0001798)1.84858138
88Oligodontia (HP:0000677)1.84055705
89Fragile skin (HP:0001030)1.83456422
90Anhidrosis (HP:0000970)1.82629342
91Abnormality of permanent molar morphology (HP:0011071)1.82560976
92Abnormality of the dental root (HP:0006486)1.82560976
93Taurodontia (HP:0000679)1.82560976
94Abnormality of cells of the erythroid lineage (HP:0012130)1.82299725
95Lack of skin elasticity (HP:0100679)1.80975146
96Fine hair (HP:0002213)1.79811956
97Breast hypoplasia (HP:0003187)1.76980419
98Abnormality of the fingernails (HP:0001231)1.75975417
99Hypoplastic labia majora (HP:0000059)1.75116422
100Sparse lateral eyebrow (HP:0005338)1.73650139
101Double outlet right ventricle (HP:0001719)1.72802796
102Congenital malformation of the right heart (HP:0011723)1.72802796
103Abnormality of molar (HP:0011077)1.72541323
104Abnormality of molar morphology (HP:0011070)1.72541323
105Abnormality of the gastric mucosa (HP:0004295)1.72069047
106Corneal dystrophy (HP:0001131)1.70406025
107Hyperhidrosis (HP:0000975)1.68953237
108Dry skin (HP:0000958)1.66127621
109Hypoplasia of the uterus (HP:0000013)1.63837575
110Absent hair (HP:0002298)1.62901469
111Conical tooth (HP:0000698)1.62877165
112Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.62087171
113Abnormality of the parietal bone (HP:0002696)1.61921276
114Abnormality of pyrimidine metabolism (HP:0004353)1.61796064
115Aplasia/hypoplasia of the uterus (HP:0008684)1.61329397
116Widely patent fontanelles and sutures (HP:0004492)1.60998699
117Intrahepatic cholestasis (HP:0001406)1.60783595
118Abnormality of the dental pulp (HP:0006479)1.60565255
119Abnormality of the labia majora (HP:0012881)1.57212722
120Abnormal number of erythroid precursors (HP:0012131)1.55787768
121Hypodontia (HP:0000668)1.54979365
122Macrocytic anemia (HP:0001972)1.54908375
123Aplasia of the phalanges of the hand (HP:0009802)1.54892061
124Increased serum ferritin (HP:0003281)1.52374622
125Furrowed tongue (HP:0000221)1.47558127
126Decreased circulating renin level (HP:0003351)1.45585869
127Craniofacial hyperostosis (HP:0004493)1.44610866
128Depressed nasal tip (HP:0000437)1.44397766
129Abnormality of glutamine family amino acid metabolism (HP:0010902)1.42276718
130Vacuolated lymphocytes (HP:0001922)1.42012490
131Subcapsular cataract (HP:0000523)1.41281030
132Skin pits (HP:0100276)1.40619369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.37558340
2MST44.98382083
3MST1R3.78180208
4MAP3K33.65708747
5MAPKAPK33.59761148
6FER3.28352945
7LATS12.72922517
8RPS6KB22.31743029
9MAP3K22.28970193
10TAOK12.08877833
11MAP3K122.04228185
12PDK32.03641408
13PDK42.03641408
14STK102.02373454
15MAP2K21.95321329
16STK38L1.91703803
17MAP3K91.85723025
18FRK1.79491691
19MAP3K111.73461850
20EPHB21.66922134
21NEK61.62724061
22NME11.60801669
23PDK21.49967350
24AKT31.49881453
25EIF2AK31.49707701
26BCR1.46652448
27DYRK31.46622140
28WEE11.42357726
29LRRK21.42229704
30ABL21.41863370
31PRKCI1.41646648
32PIM21.40088196
33STK241.34074986
34MET1.31692201
35LATS21.23619155
36RPS6KA41.21497652
37MAP2K61.21231847
38STK31.19905276
39ERN11.19519076
40TESK11.18952724
41SIK11.09658798
42BUB11.04957518
43TRPM71.04588850
44PIK3CG1.03761944
45DYRK1B1.02834516
46MAP3K11.01704494
47TTK1.01444421
48PAK40.96437791
49PTK60.93439475
50MAPK150.93366319
51AURKB0.89979716
52BRSK20.88912206
53CDK120.87043105
54CDK60.86236914
55MAPKAPK50.82849352
56EEF2K0.82177026
57TRIB30.81422257
58MAP3K80.80968070
59CDK30.79029228
60TESK20.79007019
61EPHA30.78880504
62NEK20.78315557
63IRAK30.76466702
64RIPK10.74166439
65EIF2AK10.71451577
66NME20.70818381
67LMTK20.69560792
68MAPKAPK20.68178663
69NLK0.67745525
70MUSK0.66792388
71AURKA0.66342577
72MTOR0.65103650
73TYK20.64052633
74TAOK20.60630707
75TSSK60.60556968
76EPHB10.58454050
77FGFR40.58371768
78ERBB20.56167634
79ADRBK10.56026535
80EIF2AK20.55548008
81BLK0.55407099
82TYRO30.55330584
83CDK40.53273724
84IRAK20.52843010
85SMG10.52514670
86PBK0.52089031
87MAP3K50.50297620
88AKT20.49902888
89MYLK0.49485738
90SIK30.49338550
91MATK0.49172921
92OXSR10.46046268
93PLK40.46030416
94MAP2K10.45880230
95STK380.44809204
96GSK3A0.44374198
97SRPK10.42774739
98STK390.42255108
99GRK10.40351696
100ILK0.39770421
101FGFR10.38842042
102IKBKE0.36263852
103MARK30.34208091
104MAP2K30.34179373
105RPS6KA10.33587339
106WNK40.33281588
107TNIK0.32315072
108IKBKB0.32130608
109CHEK20.32013294
110BRD40.31457455
111STK110.31214423
112PLK10.30946711
113PRKG20.30176944
114ZAK0.29485356
115PHKG20.29097450
116PHKG10.29097450
117FGFR20.28906611
118DAPK30.28670219
119PTK20.28464292
120TBK10.27656853
121CHUK0.27466723
122CDK70.26174377
123ERBB30.26013910
124PLK30.25231816
125BRAF0.25174035
126RPS6KB10.24911583
127PIK3CA0.24582376
128PIM10.24182157
129PDGFRB0.24060159
130ICK0.23972656
131STK160.23818363
132FGFR30.23306111
133TGFBR20.22500221
134MARK20.21371351
135RPS6KC10.21368060
136RPS6KL10.21368060
137PDPK10.20703373
138MAP3K140.19926894
139PRKCQ0.19617995
140NUAK10.18772473
141ERBB40.18483730
142NEK10.17375199

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.30525721
2Fat digestion and absorption_Homo sapiens_hsa049753.79179707
3Linoleic acid metabolism_Homo sapiens_hsa005913.63037965
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.59099685
5Ribosome_Homo sapiens_hsa030103.10827234
6Mineral absorption_Homo sapiens_hsa049783.00775711
7Vitamin digestion and absorption_Homo sapiens_hsa049772.93308484
8Sphingolipid metabolism_Homo sapiens_hsa006002.72297319
9Arachidonic acid metabolism_Homo sapiens_hsa005902.48493500
10Vitamin B6 metabolism_Homo sapiens_hsa007502.35223860
11Collecting duct acid secretion_Homo sapiens_hsa049662.12348127
12Ether lipid metabolism_Homo sapiens_hsa005652.02454136
13Arginine biosynthesis_Homo sapiens_hsa002201.97710186
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.93944626
15Folate biosynthesis_Homo sapiens_hsa007901.91924494
16Vibrio cholerae infection_Homo sapiens_hsa051101.90278432
17Histidine metabolism_Homo sapiens_hsa003401.83913831
18Renin-angiotensin system_Homo sapiens_hsa046141.83216868
19Protein digestion and absorption_Homo sapiens_hsa049741.75944496
20Tight junction_Homo sapiens_hsa045301.73334627
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.71165423
22Basal cell carcinoma_Homo sapiens_hsa052171.68588277
23Ovarian steroidogenesis_Homo sapiens_hsa049131.65728474
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63919858
25p53 signaling pathway_Homo sapiens_hsa041151.51312551
26Bladder cancer_Homo sapiens_hsa052191.45927506
27Glutathione metabolism_Homo sapiens_hsa004801.44683908
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35946989
29Hippo signaling pathway_Homo sapiens_hsa043901.35542904
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33024600
31Hedgehog signaling pathway_Homo sapiens_hsa043401.31632508
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26368174
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21243789
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21199766
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20317692
36Pancreatic secretion_Homo sapiens_hsa049721.18117888
37Adherens junction_Homo sapiens_hsa045201.16659698
38Retinol metabolism_Homo sapiens_hsa008301.14301317
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.13942445
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11327241
41Glycerolipid metabolism_Homo sapiens_hsa005611.10907870
42Caffeine metabolism_Homo sapiens_hsa002321.10256669
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08361628
44RNA polymerase_Homo sapiens_hsa030201.04861300
45Phenylalanine metabolism_Homo sapiens_hsa003601.03573927
46Pentose phosphate pathway_Homo sapiens_hsa000300.99127241
47Sulfur metabolism_Homo sapiens_hsa009200.99048139
48ErbB signaling pathway_Homo sapiens_hsa040120.98681625
49Fatty acid elongation_Homo sapiens_hsa000620.98086873
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97880597
51Endocytosis_Homo sapiens_hsa041440.97729962
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93945172
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91921303
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90934398
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87328528
56Small cell lung cancer_Homo sapiens_hsa052220.86665971
57mRNA surveillance pathway_Homo sapiens_hsa030150.85094007
58Hepatitis C_Homo sapiens_hsa051600.84470794
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.83731883
60Chemical carcinogenesis_Homo sapiens_hsa052040.83049161
61Dorso-ventral axis formation_Homo sapiens_hsa043200.81548565
62ECM-receptor interaction_Homo sapiens_hsa045120.80296895
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77552891
64beta-Alanine metabolism_Homo sapiens_hsa004100.75869979
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75748675
66Apoptosis_Homo sapiens_hsa042100.75396291
67Fructose and mannose metabolism_Homo sapiens_hsa000510.74783228
68Thyroid cancer_Homo sapiens_hsa052160.74643717
69VEGF signaling pathway_Homo sapiens_hsa043700.72268605
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70973992
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69984501
72Other glycan degradation_Homo sapiens_hsa005110.68770724
73Synaptic vesicle cycle_Homo sapiens_hsa047210.66558759
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65856247
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64732018
76MicroRNAs in cancer_Homo sapiens_hsa052060.63885932
77Lysosome_Homo sapiens_hsa041420.61666781
78PPAR signaling pathway_Homo sapiens_hsa033200.60972899
79Proteoglycans in cancer_Homo sapiens_hsa052050.58631978
80Toxoplasmosis_Homo sapiens_hsa051450.58087471
81Proteasome_Homo sapiens_hsa030500.56508456
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56402067
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56336182
84Amoebiasis_Homo sapiens_hsa051460.54805806
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53994666
86Fatty acid degradation_Homo sapiens_hsa000710.53081681
87TGF-beta signaling pathway_Homo sapiens_hsa043500.52663206
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52495200
89Insulin signaling pathway_Homo sapiens_hsa049100.52036696
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50726232
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.49757271
92Wnt signaling pathway_Homo sapiens_hsa043100.48411456
93Steroid biosynthesis_Homo sapiens_hsa001000.47597636
94RNA transport_Homo sapiens_hsa030130.46959373
95Fatty acid biosynthesis_Homo sapiens_hsa000610.46806155
96Circadian rhythm_Homo sapiens_hsa047100.44310861
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43896141
98Melanogenesis_Homo sapiens_hsa049160.43647961
99Renal cell carcinoma_Homo sapiens_hsa052110.42475070
100Selenocompound metabolism_Homo sapiens_hsa004500.40882696
101GnRH signaling pathway_Homo sapiens_hsa049120.40711996
102Starch and sucrose metabolism_Homo sapiens_hsa005000.40589992
103Prostate cancer_Homo sapiens_hsa052150.40318715
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40068456
105Choline metabolism in cancer_Homo sapiens_hsa052310.39429295
106ABC transporters_Homo sapiens_hsa020100.39408346
107Cell cycle_Homo sapiens_hsa041100.38905973
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.38758548
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38756714
110Arginine and proline metabolism_Homo sapiens_hsa003300.38707109
111Gastric acid secretion_Homo sapiens_hsa049710.37475247
112Biosynthesis of amino acids_Homo sapiens_hsa012300.36430285
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34457484
114Galactose metabolism_Homo sapiens_hsa000520.33683180
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33170345
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32817638
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32618967
118Metabolic pathways_Homo sapiens_hsa011000.31980698
119AMPK signaling pathway_Homo sapiens_hsa041520.31548895
120Ras signaling pathway_Homo sapiens_hsa040140.31352727
121FoxO signaling pathway_Homo sapiens_hsa040680.30849891
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.30776339
123Endometrial cancer_Homo sapiens_hsa052130.30635688
124Inositol phosphate metabolism_Homo sapiens_hsa005620.29610634
125Bile secretion_Homo sapiens_hsa049760.28465237
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27679357
127Basal transcription factors_Homo sapiens_hsa030220.26925810
128Epstein-Barr virus infection_Homo sapiens_hsa051690.25449335
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24794267
130Antigen processing and presentation_Homo sapiens_hsa046120.24781340
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23983182
132Influenza A_Homo sapiens_hsa051640.23875930
133Axon guidance_Homo sapiens_hsa043600.23271302
134HTLV-I infection_Homo sapiens_hsa051660.22863416
135Pathways in cancer_Homo sapiens_hsa052000.21918877
136Oocyte meiosis_Homo sapiens_hsa041140.20870416
137Acute myeloid leukemia_Homo sapiens_hsa052210.19903345
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19712485
139Tyrosine metabolism_Homo sapiens_hsa003500.19703838

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »