OVOL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of digestive system process (GO:0060457)9.65351992
2lung secretory cell differentiation (GO:0061140)7.78260311
3positive regulation of translational initiation (GO:0045948)7.41353332
4calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)6.43853447
5glandular epithelial cell differentiation (GO:0002067)6.33410172
6fusion of sperm to egg plasma membrane (GO:0007342)6.29660151
7sperm motility (GO:0030317)6.21313561
8mitotic metaphase plate congression (GO:0007080)5.60618479
9spermatid development (GO:0007286)5.55285223
10axonemal dynein complex assembly (GO:0070286)5.55250462
11cilium or flagellum-dependent cell motility (GO:0001539)5.51891582
12sperm-egg recognition (GO:0035036)5.44923602
13cell wall macromolecule metabolic process (GO:0044036)5.39002005
14cell wall macromolecule catabolic process (GO:0016998)5.39002005
15regulation of retinoic acid receptor signaling pathway (GO:0048385)5.38384631
16negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.37558503
17synaptonemal complex assembly (GO:0007130)5.35504539
18piRNA metabolic process (GO:0034587)5.32513278
19acrosome assembly (GO:0001675)5.31234332
20synaptonemal complex organization (GO:0070193)5.26917950
21binding of sperm to zona pellucida (GO:0007339)5.12911612
22desmosome organization (GO:0002934)5.11300269
23tight junction assembly (GO:0070830)4.92564347
24multicellular organism reproduction (GO:0032504)4.90844600
25male meiosis (GO:0007140)4.87265098
26epithelial cilium movement (GO:0003351)4.84380098
27cell-cell recognition (GO:0009988)4.79400612
28acrosome reaction (GO:0007340)4.72432801
29regulation of cilium movement (GO:0003352)4.72374038
30purine nucleobase biosynthetic process (GO:0009113)4.70583624
31plasma membrane fusion (GO:0045026)4.65931605
32male meiosis I (GO:0007141)4.59223725
33metaphase plate congression (GO:0051310)4.52278395
34microtubule depolymerization (GO:0007019)4.48081538
35meiosis I (GO:0007127)4.42816276
36positive regulation of protein homooligomerization (GO:0032464)4.34109334
37regulation of macrophage activation (GO:0043030)4.32634429
38protein autoprocessing (GO:0016540)4.29829426
39maturation of SSU-rRNA (GO:0030490)4.29151560
40negative regulation of inclusion body assembly (GO:0090084)4.22672757
41interferon-gamma secretion (GO:0072643)4.20826829
42motile cilium assembly (GO:0044458)4.19062018
43ribosomal large subunit biogenesis (GO:0042273)4.11627970
44reproduction (GO:0000003)4.10989437
45bundle of His cell to Purkinje myocyte communication (GO:0086069)4.05006664
46intestinal epithelial cell development (GO:0060576)3.98153249
47cilium movement (GO:0003341)3.97378985
48DNA methylation involved in gamete generation (GO:0043046)3.95706952
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.91203698
50termination of RNA polymerase III transcription (GO:0006386)3.91203698
51nucleobase biosynthetic process (GO:0046112)3.87775576
52meiotic nuclear division (GO:0007126)3.83077585
53negative regulation of necroptotic process (GO:0060546)3.82762830
54guanosine-containing compound biosynthetic process (GO:1901070)3.81768465
55ribosome assembly (GO:0042255)3.69804104
56meiotic cell cycle (GO:0051321)3.69693831
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.68608918
58chromosome organization involved in meiosis (GO:0070192)3.68187438
59protein localization to chromosome, centromeric region (GO:0071459)3.63677495
60primary alcohol catabolic process (GO:0034310)3.61384629
61receptor guanylyl cyclase signaling pathway (GO:0007168)3.58031363
62regulation of digestive system process (GO:0044058)3.57924376
63lung epithelial cell differentiation (GO:0060487)3.56629027
64vitamin transmembrane transport (GO:0035461)3.56478490
65negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.56062857
66negative regulation of DNA-templated transcription, elongation (GO:0032785)3.54056537
67DNA deamination (GO:0045006)3.53480933
68nucleotide-sugar biosynthetic process (GO:0009226)3.52375644
69DNA replication checkpoint (GO:0000076)3.50523120
70chromosome condensation (GO:0030261)3.49337407
71spermatogenesis (GO:0007283)3.48665428
72male gamete generation (GO:0048232)3.48509989
73blastocyst development (GO:0001824)3.46911764
74digestion (GO:0007586)3.44935052
75seminiferous tubule development (GO:0072520)3.43218511
76regulation of inclusion body assembly (GO:0090083)3.42387121
77lung cell differentiation (GO:0060479)3.40224393
78COPI coating of Golgi vesicle (GO:0048205)3.40097585
79Golgi transport vesicle coating (GO:0048200)3.40097585
80establishment of apical/basal cell polarity (GO:0035089)3.39482356
81epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.35524828
82histone exchange (GO:0043486)3.35522733
83DNA packaging (GO:0006323)3.35382809
84establishment of chromosome localization (GO:0051303)3.29124320
85gamete generation (GO:0007276)3.24666243
86regulation of cardioblast differentiation (GO:0051890)3.24512753
87single fertilization (GO:0007338)3.23782568
88* negative regulation of transcription by competitive promoter binding (GO:0010944)3.21649175
89sperm capacitation (GO:0048240)3.21214936
90regulation of spindle organization (GO:0090224)3.20862778
91regulation of water loss via skin (GO:0033561)3.17727176
92cell-cell junction assembly (GO:0007043)3.12564996
93rRNA modification (GO:0000154)3.10273442
94cellular response to arsenic-containing substance (GO:0071243)3.09557702
95folic acid metabolic process (GO:0046655)3.08906391
96histone H2B ubiquitination (GO:0033523)3.07364003
97proteasome assembly (GO:0043248)3.06904008
98ribonucleoprotein complex biogenesis (GO:0022613)3.06208147
99cellular response to cadmium ion (GO:0071276)3.05588947
100meiotic cell cycle process (GO:1903046)3.05212897
101mitotic sister chromatid segregation (GO:0000070)3.04229417
102ribosome biogenesis (GO:0042254)3.03904119
103germ cell development (GO:0007281)3.03868436
104regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.03638398
105GTP biosynthetic process (GO:0006183)3.03452467
106chromatin remodeling at centromere (GO:0031055)3.01487784
107monoubiquitinated protein deubiquitination (GO:0035520)2.97397026
108very-low-density lipoprotein particle assembly (GO:0034379)2.97394034
109regulation of spindle checkpoint (GO:0090231)2.96847194
110fertilization (GO:0009566)2.94684475
111UTP biosynthetic process (GO:0006228)2.93823182
112multicellular organismal water homeostasis (GO:0050891)2.91264581
113regulation of G0 to G1 transition (GO:0070316)2.91034453
114regulation of chromosome segregation (GO:0051983)2.90470324
115polyamine biosynthetic process (GO:0006596)2.89849019
116cellular process involved in reproduction in multicellular organism (GO:0022412)2.89546652
117regulation of microtubule-based movement (GO:0060632)2.89400461
118protein localization to kinetochore (GO:0034501)2.89347047
119nucleoside diphosphate phosphorylation (GO:0006165)2.87968310
120rRNA methylation (GO:0031167)2.87317067
121negative regulation of necrotic cell death (GO:0060547)2.86339980
122GDP-mannose metabolic process (GO:0019673)2.85857661
123ventricular cardiac muscle cell development (GO:0055015)2.85293580
124chaperone-mediated protein complex assembly (GO:0051131)2.83972239
125mitochondrial fusion (GO:0008053)2.83602868
126transcription from RNA polymerase I promoter (GO:0006360)2.82463272
127transcription from mitochondrial promoter (GO:0006390)2.80491452
128establishment of skin barrier (GO:0061436)2.79992331
129formation of translation preinitiation complex (GO:0001731)2.78966217
130DNA-templated transcription, elongation (GO:0006354)2.78619252
131mitochondrial calcium ion transport (GO:0006851)2.77747389
132regulation of mitochondrial translation (GO:0070129)2.77662177
133rRNA metabolic process (GO:0016072)2.77396726
134GMP metabolic process (GO:0046037)2.76216683
135CENP-A containing nucleosome assembly (GO:0034080)2.75766845
1367-methylguanosine mRNA capping (GO:0006370)2.75668981
137rRNA processing (GO:0006364)2.74753089
138transcription elongation from RNA polymerase II promoter (GO:0006368)2.73423124
139folic acid transport (GO:0015884)2.71328031
140reciprocal DNA recombination (GO:0035825)2.70451513
141reciprocal meiotic recombination (GO:0007131)2.70451513
142transcription elongation from RNA polymerase I promoter (GO:0006362)2.69899951
143UDP-N-acetylglucosamine metabolic process (GO:0006047)2.69602569
144protein complex localization (GO:0031503)2.69551525
145termination of RNA polymerase I transcription (GO:0006363)2.69400650
146positive regulation of epidermal cell differentiation (GO:0045606)2.67768738
147regulation of translational initiation (GO:0006446)2.66899334
148negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.66488249
149natural killer cell mediated immunity (GO:0002228)2.66026300
150natural killer cell mediated cytotoxicity (GO:0042267)2.66026300
151proline biosynthetic process (GO:0006561)2.63778078
152regulation of necroptotic process (GO:0060544)2.61690713
153epithelial cell-cell adhesion (GO:0090136)2.61407613
154receptor recycling (GO:0001881)2.60474143
155negative regulation of keratinocyte proliferation (GO:0010839)2.60170880
156positive regulation of Cdc42 GTPase activity (GO:0043089)2.59422759
157establishment of monopolar cell polarity (GO:0061162)2.59342510
158establishment or maintenance of monopolar cell polarity (GO:0061339)2.59342510
159negative regulation of meiotic cell cycle (GO:0051447)2.58777488
160regulation of transcription from RNA polymerase I promoter (GO:0006356)2.58153040
161activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.56837977
162pyrimidine-containing compound transmembrane transport (GO:0072531)2.54715228
163maternal placenta development (GO:0001893)2.54220416
164ethanol metabolic process (GO:0006067)2.53025470
165keratinocyte proliferation (GO:0043616)2.52742484
166gap junction assembly (GO:0016264)2.52194711
167nucleobase-containing small molecule interconversion (GO:0015949)2.47043296
168regulation of transforming growth factor beta2 production (GO:0032909)2.41624138
169transcytosis (GO:0045056)2.41508845
170ribosomal small subunit biogenesis (GO:0042274)2.41446709
171sphingomyelin metabolic process (GO:0006684)2.40419022
172protein maturation by protein folding (GO:0022417)2.39561771
173cellular aldehyde metabolic process (GO:0006081)2.39197642
174regulation of protein homooligomerization (GO:0032462)2.38225885
175regulation of transforming growth factor beta1 production (GO:0032908)2.34975875
176establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.32818464
177regulation of cell maturation (GO:1903429)2.32338473
178autophagic vacuole assembly (GO:0000045)2.32306841
179columnar/cuboidal epithelial cell differentiation (GO:0002065)2.32075338
180nucleoside diphosphate biosynthetic process (GO:0009133)2.32054577
181O-glycan processing (GO:0016266)2.30688138
182water homeostasis (GO:0030104)2.30424500
183establishment or maintenance of bipolar cell polarity (GO:0061245)2.28660707
184establishment or maintenance of apical/basal cell polarity (GO:0035088)2.28660707
185regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.28168299
186regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.26503601
187cyclooxygenase pathway (GO:0019371)2.26432522
188negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.25684475

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.75295434
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.85954737
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.32201161
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.16578239
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15289979
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.13181547
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10963936
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05821079
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.01250373
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.89961112
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72908839
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.56051849
13CDX2_20551321_ChIP-Seq_CACO-2_Human2.54389336
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47167167
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.42605909
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42589298
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.40238192
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.36420331
19SOX2_27498859_Chip-Seq_STOMACH_Mouse2.31956241
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.26261448
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24411048
22E2F7_22180533_ChIP-Seq_HELA_Human2.16166095
23AR_21909140_ChIP-Seq_LNCAP_Human2.14430604
24ESR1_21235772_ChIP-Seq_MCF-7_Human2.13358381
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08583196
26CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.98411715
27RACK7_27058665_Chip-Seq_MCF-7_Human1.94928564
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.93477846
29VDR_23849224_ChIP-Seq_CD4+_Human1.87645744
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.87545963
31KAP1_22055183_ChIP-Seq_ESCs_Mouse1.85896179
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.84507619
33ZNF263_19887448_ChIP-Seq_K562_Human1.83684750
34DCP1A_22483619_ChIP-Seq_HELA_Human1.81236200
35GATA6_25053715_ChIP-Seq_YYC3_Human1.77610215
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76774035
37XRN2_22483619_ChIP-Seq_HELA_Human1.75412803
38* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73313054
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72822024
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70464801
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68794135
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.63207792
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62305272
44GABP_19822575_ChIP-Seq_HepG2_Human1.61730953
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59080872
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58489626
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56110692
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55102596
49FOXP3_21729870_ChIP-Seq_TREG_Human1.52184193
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.51959893
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49729375
52SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.48319407
53TTF2_22483619_ChIP-Seq_HELA_Human1.46078820
54GATA4_25053715_ChIP-Seq_YYC3_Human1.46060395
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44599099
56* RUNX1_27514584_Chip-Seq_MCF-7_Human1.43004848
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41997375
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41000161
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40928780
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40086777
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39650040
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39096420
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38077520
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37333802
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35591681
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32086992
67KDM5A_27292631_Chip-Seq_BREAST_Human1.30681276
68ELF5_23300383_ChIP-Seq_T47D_Human1.30188544
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29473865
70CHD1_26751641_Chip-Seq_LNCaP_Human1.27992090
71GATA3_24758297_ChIP-Seq_MCF-7_Human1.27984686
72* KLF5_25053715_ChIP-Seq_YYC3_Human1.27927348
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27893353
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.27120722
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26572695
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25770225
77* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25715999
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25274712
79GATA3_21867929_ChIP-Seq_CD8_Mouse1.24900956
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.24030890
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23776924
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23776924
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23776924
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23731180
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21816787
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21416050
87ATF3_27146783_Chip-Seq_COLON_Human1.18293182
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17261873
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16590520
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16037163
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15735178
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.15207180
93SOX2_20726797_ChIP-Seq_SW620_Human1.14860050
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14488001
95PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13178129
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13094360
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11241120
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10094750
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09866490
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08862627
101NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06748696
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06409829
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03897131
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02777396
105* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02622803
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01100213
107KAP1_27257070_Chip-Seq_ESCs_Mouse1.00505767
108TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.99547597
109FLI1_21867929_ChIP-Seq_CD8_Mouse0.99242330
110ELK1_22589737_ChIP-Seq_MCF10A_Human0.98591084
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98512246
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97572441
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97019283
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.96174798
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95690874
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95283144
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95225237
118PHF8_20622854_ChIP-Seq_HELA_Human0.94991943
119RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94482283
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94105453
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94062186
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93451125
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92784532
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.92613667
125CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92302493
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.91923704
127STAT1_17558387_ChIP-Seq_HELA_Human0.91821505
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91794009
129POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91617455
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91588435
131KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91408906
132THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90772153
133SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90691998
134TET1_21451524_ChIP-Seq_MESCs_Mouse0.89400486
135SOX2_22085726_ChIP-Seq_NPCs_Mouse0.88433251
136FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87289288
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86938816
138FOXP1_21924763_ChIP-Seq_HESCs_Human0.86491310
139SRF_21415370_ChIP-Seq_HL-1_Mouse0.86369441
140ZNF274_21170338_ChIP-Seq_K562_Hela0.85876221
141FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85806554
142PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85375186
143E2F1_21310950_ChIP-Seq_MCF-7_Human0.84630238
144P53_21459846_ChIP-Seq_SAOS-2_Human0.84577721
145SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84313334
146* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.82685704
147RARA_24833708_ChIP-Seq_LIVER_Mouse0.81958808
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81949569
149FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81026520
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80892413
151YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80482679
152BCOR_27268052_Chip-Seq_Bcells_Human0.79167398
153* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79064281
154EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77811590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.20721861
2MP0003693_abnormal_embryo_hatching5.37111069
3MP0009840_abnormal_foam_cell3.83725378
4MP0008877_abnormal_DNA_methylation3.71649900
5MP0001929_abnormal_gametogenesis3.56207507
6MP0001664_abnormal_digestion3.45728394
7MP0003698_abnormal_male_reproductive3.29880508
8MP0003123_paternal_imprinting3.26294570
9MP0003111_abnormal_nucleus_morphology3.16406951
10MP0004957_abnormal_blastocyst_morpholog3.15035952
11MP0005083_abnormal_biliary_tract2.95405648
12MP0000470_abnormal_stomach_morphology2.80464576
13MP0000566_synostosis2.75704930
14MP0002210_abnormal_sex_determination2.70842657
15MP0003718_maternal_effect2.70092202
16MP0002102_abnormal_ear_morphology2.63413829
17MP0002653_abnormal_ependyma_morphology2.57644042
18MP0010094_abnormal_chromosome_stability2.53582848
19MP0003077_abnormal_cell_cycle2.41660401
20MP0001145_abnormal_male_reproductive2.41532555
21MP0005501_abnormal_skin_physiology2.38786068
22MP0003191_abnormal_cellular_cholesterol2.30718059
23MP0002089_abnormal_postnatal_growth/wei2.22887539
24MP0003786_premature_aging2.18782794
25MP0008058_abnormal_DNA_repair2.17720619
26MP0000653_abnormal_sex_gland2.15066577
27MP0003806_abnormal_nucleotide_metabolis2.14326516
28MP0005165_increased_susceptibility_to2.11993980
29MP0008260_abnormal_autophagy2.09862519
30MP0002098_abnormal_vibrissa_morphology1.90244667
31MP0002161_abnormal_fertility/fecundity1.88989367
32MP0003941_abnormal_skin_development1.87513232
33MP0004185_abnormal_adipocyte_glucose1.82938826
34MP0000579_abnormal_nail_morphology1.73890841
35MP0001663_abnormal_digestive_system1.72809514
36MP0004264_abnormal_extraembryonic_tissu1.72604403
37MP0010678_abnormal_skin_adnexa1.69695299
38MP0008995_early_reproductive_senescence1.66896573
39MP0009379_abnormal_foot_pigmentation1.66544396
40MP0003878_abnormal_ear_physiology1.64584047
41MP0005377_hearing/vestibular/ear_phenot1.64584047
42MP0001849_ear_inflammation1.59990654
43MP0008932_abnormal_embryonic_tissue1.59954299
44MP0001730_embryonic_growth_arrest1.59145133
45MP0002254_reproductive_system_inflammat1.56680188
46* MP0005381_digestive/alimentary_phenotyp1.54603147
47MP0002909_abnormal_adrenal_gland1.54221416
48MP0010352_gastrointestinal_tract_polyps1.53924522
49MP0005389_reproductive_system_phenotype1.52725774
50MP0005085_abnormal_gallbladder_physiolo1.51332944
51MP0002163_abnormal_gland_morphology1.50776198
52MP0008057_abnormal_DNA_replication1.47437186
53MP0001346_abnormal_lacrimal_gland1.46176588
54MP0002160_abnormal_reproductive_system1.45638698
55MP0004381_abnormal_hair_follicle1.44874953
56MP0001986_abnormal_taste_sensitivity1.43785953
57MP0000477_abnormal_intestine_morphology1.41035449
58MP0009780_abnormal_chondrocyte_physiolo1.40807130
59MP0008004_abnormal_stomach_pH1.37376049
60MP0005666_abnormal_adipose_tissue1.35050513
61MP0004019_abnormal_vitamin_homeostasis1.33827798
62MP0000467_abnormal_esophagus_morphology1.33224242
63MP0001919_abnormal_reproductive_system1.31260051
64MP0010030_abnormal_orbit_morphology1.29800294
65MP0004043_abnormal_pH_regulation1.29646675
66MP0005409_darkened_coat_color1.28791242
67MP0002132_abnormal_respiratory_system1.27735426
68MP0003453_abnormal_keratinocyte_physiol1.22787061
69MP0001666_abnormal_nutrient_absorption1.21378208
70MP0004782_abnormal_surfactant_physiolog1.20416035
71MP0003879_abnormal_hair_cell1.18775259
72MP0003705_abnormal_hypodermis_morpholog1.18648521
73MP0008007_abnormal_cellular_replicative1.17876400
74* MP0005380_embryogenesis_phenotype1.17752592
75* MP0001672_abnormal_embryogenesis/_devel1.17752592
76MP0001873_stomach_inflammation1.16814663
77MP0000490_abnormal_crypts_of1.15316487
78MP0005670_abnormal_white_adipose1.14705077
79MP0000383_abnormal_hair_follicle1.14533443
80MP0002693_abnormal_pancreas_physiology1.14399234
81MP0000627_abnormal_mammary_gland1.14292595
82MP0010771_integument_phenotype1.12550440
83MP0000613_abnormal_salivary_gland1.12327251
84MP0003787_abnormal_imprinting1.08725815
85MP0010155_abnormal_intestine_physiology1.08339592
86MP0005379_endocrine/exocrine_gland_phen1.07369175
87MP0001944_abnormal_pancreas_morphology1.03673421
88MP0001765_abnormal_ion_homeostasis1.02975914
89MP0003315_abnormal_perineum_morphology1.02849633
90MP0000762_abnormal_tongue_morphology1.01976855
91MP0000678_abnormal_parathyroid_gland1.01897116
92MP0003136_yellow_coat_color1.01690712
93MP0002796_impaired_skin_barrier0.98852537
94MP0000350_abnormal_cell_proliferation0.98104074
95MP0005636_abnormal_mineral_homeostasis0.97385458
96MP0010307_abnormal_tumor_latency0.96707565
97MP0005220_abnormal_exocrine_pancreas0.94964830
98MP0010234_abnormal_vibrissa_follicle0.91212827
99MP0005451_abnormal_body_composition0.90734610
100* MP0000462_abnormal_digestive_system0.90406018
101MP0002234_abnormal_pharynx_morphology0.90159413
102MP0000647_abnormal_sebaceous_gland0.90037372
103* MP0002080_prenatal_lethality0.89928702
104MP0002233_abnormal_nose_morphology0.89756279
105MP0001188_hyperpigmentation0.87569291
106MP0002111_abnormal_tail_morphology0.85970984
107MP0006036_abnormal_mitochondrial_physio0.85458520
108* MP0003984_embryonic_growth_retardation0.84111870
109* MP0001697_abnormal_embryo_size0.83479376
110MP0001881_abnormal_mammary_gland0.83228682
111MP0003699_abnormal_female_reproductive0.82563414
112* MP0002088_abnormal_embryonic_growth/wei0.79792275
113MP0001764_abnormal_homeostasis0.79297638
114MP0002249_abnormal_larynx_morphology0.78224717
115MP0005395_other_phenotype0.78142217
116MP0005257_abnormal_intraocular_pressure0.78025639
117MP0009672_abnormal_birth_weight0.77828923
118MP0001756_abnormal_urination0.77389158
119MP0001216_abnormal_epidermal_layer0.74542549
120* MP0003119_abnormal_digestive_system0.73558368
121MP0008872_abnormal_physiological_respon0.73472319
122MP0002060_abnormal_skin_morphology0.71694198
123MP0001485_abnormal_pinna_reflex0.71278838
124MP0001661_extended_life_span0.71093845
125MP0004858_abnormal_nervous_system0.69687928
126MP0003186_abnormal_redox_activity0.69285776
127MP0005310_abnormal_salivary_gland0.68123511
128MP0000537_abnormal_urethra_morphology0.68033140
129* MP0000313_abnormal_cell_death0.67156920
130MP0009643_abnormal_urine_homeostasis0.67054613
131* MP0002085_abnormal_embryonic_tissue0.66461972
132MP0004233_abnormal_muscle_weight0.63377821
133MP0002822_catalepsy0.63332996
134MP0005365_abnormal_bile_salt0.62892832
135MP0009931_abnormal_skin_appearance0.60865450
136MP0002277_abnormal_respiratory_mucosa0.60688821
137MP0002009_preneoplasia0.60200104
138MP0000428_abnormal_craniofacial_morphol0.60154445
139MP0001119_abnormal_female_reproductive0.59688350
140* MP0002084_abnormal_developmental_patter0.58803740
141MP0006292_abnormal_olfactory_placode0.58352762
142* MP0002086_abnormal_extraembryonic_tissu0.58240270
143MP0002169_no_abnormal_phenotype0.57771380
144MP0000377_abnormal_hair_follicle0.57241259
145MP0002873_normal_phenotype0.56736850
146MP0005174_abnormal_tail_pigmentation0.55833952
147MP0000432_abnormal_head_morphology0.55506117
148MP0000750_abnormal_muscle_regeneration0.55288628
149MP0003936_abnormal_reproductive_system0.55247164
150MP0003283_abnormal_digestive_organ0.54847655
151MP0000015_abnormal_ear_pigmentation0.52422291

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.57834706
2Absent/shortened dynein arms (HP:0200106)6.49276621
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.49276621
4Broad metatarsal (HP:0001783)5.51788712
5Chronic bronchitis (HP:0004469)5.39927727
6Vertebral arch anomaly (HP:0008438)5.20722382
7Abnormal respiratory epithelium morphology (HP:0012253)5.03207076
8Abnormal respiratory motile cilium morphology (HP:0005938)5.03207076
9Abnormal respiratory motile cilium physiology (HP:0012261)4.93729784
10Ventricular fibrillation (HP:0001663)4.77242093
11Impulsivity (HP:0100710)4.54488060
12Infertility (HP:0000789)4.51114984
13Male infertility (HP:0003251)4.39683866
14Rhinitis (HP:0012384)4.28419801
15Abnormal spermatogenesis (HP:0008669)3.88287642
16Right ventricular cardiomyopathy (HP:0011663)3.77197905
17Hyperglycinemia (HP:0002154)3.73939442
18Beaking of vertebral bodies (HP:0004568)3.56124703
19Abnormal ciliary motility (HP:0012262)3.49488821
20Abnormality of the lumbar spine (HP:0100712)3.45816598
21Redundant skin (HP:0001582)3.39792868
22Rough bone trabeculation (HP:0100670)3.36542933
23Gout (HP:0001997)3.34306580
24Abnormality of the preputium (HP:0100587)3.32632650
25Breast hypoplasia (HP:0003187)3.26236818
26Abnormal tarsal ossification (HP:0008369)3.21172442
27Bundle branch block (HP:0011710)3.20401014
28Azoospermia (HP:0000027)3.15527063
29Hyperactive renin-angiotensin system (HP:0000841)3.14029272
30Trismus (HP:0000211)3.09888709
31Thoracic kyphosis (HP:0002942)3.03843265
32Ileus (HP:0002595)3.01288714
33Ureteral duplication (HP:0000073)2.99614944
34Tubulointerstitial nephritis (HP:0001970)2.98370861
35Abnormal hair laboratory examination (HP:0003328)2.90924130
36Reticulocytopenia (HP:0001896)2.86185567
37Secondary amenorrhea (HP:0000869)2.78451750
38Congenital ichthyosiform erythroderma (HP:0007431)2.77935745
39Cerebral hypomyelination (HP:0006808)2.77700255
40Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.73044392
41Radial bowing (HP:0002986)2.71973968
42Hyperglycinuria (HP:0003108)2.69357665
43Carpal bone hypoplasia (HP:0001498)2.67419097
44Bronchiectasis (HP:0002110)2.64198227
45Intrahepatic cholestasis (HP:0001406)2.59957184
46Birth length less than 3rd percentile (HP:0003561)2.54641280
47Long toe (HP:0010511)2.52015257
48Abnormality of the thoracic spine (HP:0100711)2.51062425
49Abnormal trabecular bone morphology (HP:0100671)2.50047984
50Renal salt wasting (HP:0000127)2.46338831
51Bronchitis (HP:0012387)2.45270529
52Abnormality of the fetal cardiovascular system (HP:0010948)2.44108120
53Abnormal umbilical cord blood vessels (HP:0011403)2.44108120
54Single umbilical artery (HP:0001195)2.44108120
55Septate vagina (HP:0001153)2.41230437
56Progressive muscle weakness (HP:0003323)2.39971689
57Amelogenesis imperfecta (HP:0000705)2.39776689
58Absent thumb (HP:0009777)2.38190643
59Mesomelia (HP:0003027)2.37489885
60Insulin-resistant diabetes mellitus (HP:0000831)2.34544951
61Facial cleft (HP:0002006)2.31381953
62Lip pit (HP:0100267)2.31043502
63Death in infancy (HP:0001522)2.30558111
64Nasal polyposis (HP:0100582)2.27300687
65Premature ovarian failure (HP:0008209)2.27056577
66Bowing of the arm (HP:0006488)2.25568868
67Bowed forearm bones (HP:0003956)2.25568868
68Multiple enchondromatosis (HP:0005701)2.24367271
69Abnormality of cells of the erythroid lineage (HP:0012130)2.24063797
70Hyperphosphatemia (HP:0002905)2.23213097
71Hyperglycemia (HP:0003074)2.23148290
72Congenital malformation of the right heart (HP:0011723)2.22544350
73Double outlet right ventricle (HP:0001719)2.22544350
74Posterior subcapsular cataract (HP:0007787)2.22150714
75Meckel diverticulum (HP:0002245)2.19325015
76Macrocytic anemia (HP:0001972)2.18876832
77Abnormality of monocarboxylic acid metabolism (HP:0010996)2.18838093
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.17735866
79Glucose intolerance (HP:0000833)2.17666646
8011 pairs of ribs (HP:0000878)2.17373707
81Abnormal number of erythroid precursors (HP:0012131)2.16620581
82Cleft eyelid (HP:0000625)2.14516146
83Abnormal pancreas size (HP:0012094)2.11501304
84Abnormality of chromosome stability (HP:0003220)2.10742894
85Abnormality of the dental root (HP:0006486)2.10409965
86Taurodontia (HP:0000679)2.10409965
87Abnormality of permanent molar morphology (HP:0011071)2.10409965
88Pustule (HP:0200039)2.09348912
89Oral leukoplakia (HP:0002745)2.07529585
90Abnormality of carpal bone ossification (HP:0006257)2.06996738
91Hypoplasia of the radius (HP:0002984)2.05947129
92Delusions (HP:0000746)2.05656993
93Abnormality of the distal phalanges of the toes (HP:0010182)2.05119571
94Flat acetabular roof (HP:0003180)2.04310791
95Subcapsular cataract (HP:0000523)2.02764825
96Abnormal biliary tract morphology (HP:0012440)2.02650567
97Abnormal foot bone ossification (HP:0010675)2.01701901
98Entropion (HP:0000621)1.98746777
99Abnormality of the ileum (HP:0001549)1.97221560
100Chromsome breakage (HP:0040012)1.97116871
101CNS hypomyelination (HP:0003429)1.96809612
102Flared metaphyses (HP:0003015)1.95818989
103Abnormality of glycine metabolism (HP:0010895)1.95262564
104Abnormality of serine family amino acid metabolism (HP:0010894)1.95262564
105Gonadotropin excess (HP:0000837)1.93957582
106Limited elbow extension (HP:0001377)1.92894549
107Abnormality of serum amino acid levels (HP:0003112)1.92234846
108Horseshoe kidney (HP:0000085)1.91895487
109Degeneration of anterior horn cells (HP:0002398)1.91721593
110Abnormality of the anterior horn cell (HP:0006802)1.91721593
111Microretrognathia (HP:0000308)1.91541903
112Broad hallux (HP:0010055)1.91016795
113Abnormality of molar morphology (HP:0011070)1.90168106
114Abnormality of molar (HP:0011077)1.90168106
115Sparse eyelashes (HP:0000653)1.90067470
116Abnormality of glycolysis (HP:0004366)1.86842201
117Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.86584229
118Malnutrition (HP:0004395)1.86133313
119Abnormal hemoglobin (HP:0011902)1.85637762
120Progressive hearing impairment (HP:0001730)1.84893869
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84445241
122Abnormality of the umbilical cord (HP:0010881)1.84256720
123Myopathic facies (HP:0002058)1.84141514
124Abnormality of the dental pulp (HP:0006479)1.82983400
125Colon cancer (HP:0003003)1.82926173
126Abnormality of alanine metabolism (HP:0010916)1.82471144
127Hyperalaninemia (HP:0003348)1.82471144
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82471144
129Curly hair (HP:0002212)1.82392750
130Abnormality of the aortic arch (HP:0012303)1.82166395
131Villous atrophy (HP:0011473)1.81881041
132Abnormality of small intestinal villus morphology (HP:0011472)1.81881041
133Pili torti (HP:0003777)1.81454897
134Oligodactyly (hands) (HP:0001180)1.81206053
135Duodenal stenosis (HP:0100867)1.80858343
136Small intestinal stenosis (HP:0012848)1.80858343
137Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80394636
138Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80366035
139Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.80294102
140Nephronophthisis (HP:0000090)1.80153527
141Short nail (HP:0001799)1.79856819
142Personality changes (HP:0000751)1.78986371
143Abnormality of chloride homeostasis (HP:0011422)1.77840719
144Hyperuricemia (HP:0002149)1.77539525
145External ophthalmoplegia (HP:0000544)1.76628725
146Plantar hyperkeratosis (HP:0007556)1.75031000
147Absent radius (HP:0003974)1.74619422
148Aplasia/Hypoplasia of the patella (HP:0006498)1.74337419
149Poikiloderma (HP:0001029)1.74080904
150Abnormality of the salivary glands (HP:0010286)1.73869694
151Tongue fasciculations (HP:0001308)1.73050637
152Abnormalities of placenta or umbilical cord (HP:0001194)1.72157554
153Heart block (HP:0012722)1.71590430
154Hyperammonemia (HP:0001987)1.71091336
155Fragile nails (HP:0001808)1.70236224
156Oligodactyly (HP:0012165)1.68605103
157Stenosis of the external auditory canal (HP:0000402)1.68411353
158Testicular atrophy (HP:0000029)1.67648631
159Increased purine levels (HP:0004368)1.67354811
160Patent foramen ovale (HP:0001655)1.67201141
161Abnormality of the epiphyses of the hand (HP:0005924)1.66472014
162Abnormal ventriculo-arterial connection (HP:0011563)1.65926160
163Transposition of the great arteries (HP:0001669)1.65926160
164Abnormal connection of the cardiac segments (HP:0011545)1.65926160
165Selective tooth agenesis (HP:0001592)1.64356387

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.22216413
2PDK34.57856248
3PDK44.57856248
4BUB14.24922680
5NEK23.23143559
6PDK23.00278539
7WEE12.90768851
8TLK12.52260409
9TESK12.50208556
10PRKD32.45242020
11AKT32.43431034
12TTK2.41953740
13TRIB32.41489965
14LMTK22.40694243
15BRSK22.14148381
16MST42.06994540
17CCNB11.98551115
18STK161.88845118
19STK38L1.88707187
20SMG11.88188948
21PLK41.72549294
22MAP2K61.69971801
23BRAF1.67321666
24EPHA21.61849605
25PASK1.60718181
26PLK11.58660238
27MET1.56076616
28DYRK31.51040572
29STK391.41968238
30NME21.39460963
31MAP3K91.39334709
32IRAK31.39172631
33EEF2K1.38323906
34BRSK11.30947566
35ERN11.26709905
36ARAF1.25263099
37WNK41.21435582
38NME11.19748330
39TSSK61.17997478
40PLK31.17471190
41STK381.16088516
42MAP2K21.15999467
43CHEK21.15240218
44RIPK11.14123381
45CDK81.12946653
46MAPK151.10340647
47AURKB1.06393687
48STK241.03709612
49PAK41.03350390
50PKN21.03245846
51STK31.02463057
52ACVR1B1.01711768
53RPS6KA40.93695439
54STK40.87088131
55AURKA0.86325758
56SRPK10.84194015
57PRKCI0.83961359
58SIK10.83633663
59EIF2AK30.82911537
60MKNK20.81568232
61BMX0.80416461
62SCYL20.78358220
63PNCK0.75031343
64ZAK0.74009751
65MAP3K120.71299554
66PTK20.69695035
67VRK20.68781530
68ICK0.66600858
69DMPK0.65910674
70CHEK10.64341999
71VRK10.64010773
72LATS20.63491503
73CDK190.60801368
74PAK10.60648212
75ILK0.59441828
76CDC70.57645782
77MAP3K30.57248081
78PTK60.55755964
79ATR0.55614787
80NUAK10.54921737
81NEK60.54103532
82PINK10.54070544
83MAPKAPK30.52448219
84FRK0.51700930
85CASK0.50302664
86MAP3K100.48248707
87CDK30.47924040
88TESK20.47665307
89MAP3K20.45986049
90FER0.42890391
91PRKD20.42835172
92TAOK10.42813348
93OXSR10.42008080
94PIM20.41827564
95CDK20.41252292
96AKT20.39308959
97ATM0.38718794
98CSNK2A20.38300659
99CSNK2A10.37871314
100MTOR0.37387879
101MAP3K80.36331276
102LRRK20.36158499
103PDK10.36091532
104CDK40.35346345
105CSNK1E0.34902830
106ALK0.34460844
107CDK70.34308171
108MUSK0.33082674
109PDPK10.32451053
110PRKAA10.32264727
111NEK10.31718756
112CSNK1A10.31123997
113ZAP700.30722252
114BCKDK0.29448741
115IRAK20.29346988
116RPS6KB20.29002141
117FGFR10.28841009
118CAMK1D0.26970903
119MELK0.26269585
120CAMKK20.26021357
121CDK10.25452173
122PBK0.25405717
123ERBB40.24989811
124MAP2K10.23841804
125EPHB20.23456539
126EIF2AK20.23389516
127MST1R0.22945677
128GRK50.22704196
129DAPK20.22331940
130PRKG20.22164450
131PRKCG0.21895668
132TRIM280.21776391
133PDGFRB0.19815266
134WNK30.19130795
135RPS6KB10.19099626
136LATS10.18288762
137RPS6KA10.18243623
138ADRBK20.17885936
139MAP3K10.16772728
140MKNK10.16574180
141DYRK1B0.16535495

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.30324705
2RNA polymerase_Homo sapiens_hsa030204.17929595
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.69217698
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.00119539
5Ribosome_Homo sapiens_hsa030102.91395902
6RNA transport_Homo sapiens_hsa030132.76821352
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.63397691
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.54648319
9Pyrimidine metabolism_Homo sapiens_hsa002402.44200477
10Proteasome_Homo sapiens_hsa030502.39368548
11Basal transcription factors_Homo sapiens_hsa030222.36254979
12Folate biosynthesis_Homo sapiens_hsa007902.36190562
13Steroid biosynthesis_Homo sapiens_hsa001002.31597964
14Fanconi anemia pathway_Homo sapiens_hsa034601.99968292
15Purine metabolism_Homo sapiens_hsa002301.91780009
16Spliceosome_Homo sapiens_hsa030401.81281741
17Homologous recombination_Homo sapiens_hsa034401.80334739
18Cell cycle_Homo sapiens_hsa041101.69778008
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.67383381
20Linoleic acid metabolism_Homo sapiens_hsa005911.56629295
21Regulation of autophagy_Homo sapiens_hsa041401.55958300
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.53034129
23DNA replication_Homo sapiens_hsa030301.51975289
24Protein export_Homo sapiens_hsa030601.51117053
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50830705
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50573563
27Pentose phosphate pathway_Homo sapiens_hsa000301.49497680
28Mismatch repair_Homo sapiens_hsa034301.48641170
29Huntingtons disease_Homo sapiens_hsa050161.47137526
30Histidine metabolism_Homo sapiens_hsa003401.43903977
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43390352
32Oocyte meiosis_Homo sapiens_hsa041141.41277643
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38778053
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38112544
35Phenylalanine metabolism_Homo sapiens_hsa003601.38061108
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37685442
37Selenocompound metabolism_Homo sapiens_hsa004501.33641384
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30645262
39Vitamin digestion and absorption_Homo sapiens_hsa049771.28506731
40Base excision repair_Homo sapiens_hsa034101.25906262
41Fructose and mannose metabolism_Homo sapiens_hsa000511.25492603
42p53 signaling pathway_Homo sapiens_hsa041151.22159840
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.21991030
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.20003041
45Fatty acid degradation_Homo sapiens_hsa000711.19349622
46Sulfur metabolism_Homo sapiens_hsa009201.14992399
47mRNA surveillance pathway_Homo sapiens_hsa030151.14966990
48Chemical carcinogenesis_Homo sapiens_hsa052041.12455380
49Sulfur relay system_Homo sapiens_hsa041221.11681879
50Nucleotide excision repair_Homo sapiens_hsa034201.09820428
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08883883
52Fat digestion and absorption_Homo sapiens_hsa049751.03895034
53Mineral absorption_Homo sapiens_hsa049781.00891385
54Fatty acid elongation_Homo sapiens_hsa000621.00515273
55Pancreatic secretion_Homo sapiens_hsa049721.00201035
56Hepatitis C_Homo sapiens_hsa051601.00041195
57Caffeine metabolism_Homo sapiens_hsa002320.99258803
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99055093
59Glutathione metabolism_Homo sapiens_hsa004800.97710806
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97311821
61Fatty acid metabolism_Homo sapiens_hsa012120.96159622
62Tyrosine metabolism_Homo sapiens_hsa003500.95106113
63Oxidative phosphorylation_Homo sapiens_hsa001900.94597485
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94231529
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90842845
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88249777
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85582619
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82063323
69Glycerolipid metabolism_Homo sapiens_hsa005610.81251148
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81100438
71Epstein-Barr virus infection_Homo sapiens_hsa051690.80645748
72Adherens junction_Homo sapiens_hsa045200.79478107
73Insulin secretion_Homo sapiens_hsa049110.79397642
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79360372
75Arginine biosynthesis_Homo sapiens_hsa002200.78296344
76Arachidonic acid metabolism_Homo sapiens_hsa005900.77550789
77RNA degradation_Homo sapiens_hsa030180.74359653
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72378302
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.71154786
80Pyruvate metabolism_Homo sapiens_hsa006200.71038664
81Biosynthesis of amino acids_Homo sapiens_hsa012300.70913969
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.70765343
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66919915
84Metabolic pathways_Homo sapiens_hsa011000.64702514
85Collecting duct acid secretion_Homo sapiens_hsa049660.63012672
86Protein digestion and absorption_Homo sapiens_hsa049740.62785282
87beta-Alanine metabolism_Homo sapiens_hsa004100.62705721
88Peroxisome_Homo sapiens_hsa041460.60738379
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60338203
90Renin-angiotensin system_Homo sapiens_hsa046140.59379692
91Arginine and proline metabolism_Homo sapiens_hsa003300.59303018
92Starch and sucrose metabolism_Homo sapiens_hsa005000.59070290
93N-Glycan biosynthesis_Homo sapiens_hsa005100.58923099
94Vibrio cholerae infection_Homo sapiens_hsa051100.58862627
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57376420
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57196697
97Parkinsons disease_Homo sapiens_hsa050120.57180352
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56717290
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56192652
100Glucagon signaling pathway_Homo sapiens_hsa049220.54540279
101Sphingolipid metabolism_Homo sapiens_hsa006000.52331217
102Amphetamine addiction_Homo sapiens_hsa050310.49713089
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48691727
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.47087491
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46314057
106Carbon metabolism_Homo sapiens_hsa012000.45600461
107Thyroid cancer_Homo sapiens_hsa052160.44594343
108Alzheimers disease_Homo sapiens_hsa050100.40831821
109Ether lipid metabolism_Homo sapiens_hsa005650.40467812
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.39458076
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37803650
112Insulin signaling pathway_Homo sapiens_hsa049100.36228866
113Tight junction_Homo sapiens_hsa045300.34072410
114Dorso-ventral axis formation_Homo sapiens_hsa043200.33719639
115Thyroid hormone synthesis_Homo sapiens_hsa049180.33393485
116Lysine degradation_Homo sapiens_hsa003100.32962405
117Circadian rhythm_Homo sapiens_hsa047100.31883192
118Galactose metabolism_Homo sapiens_hsa000520.31738522
119Fatty acid biosynthesis_Homo sapiens_hsa000610.31302463
120Taste transduction_Homo sapiens_hsa047420.31252818
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30929174
122Antigen processing and presentation_Homo sapiens_hsa046120.27681122
123Synaptic vesicle cycle_Homo sapiens_hsa047210.27384765
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25990363
125Cardiac muscle contraction_Homo sapiens_hsa042600.25026837
126One carbon pool by folate_Homo sapiens_hsa006700.24626460
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23746178
128Inositol phosphate metabolism_Homo sapiens_hsa005620.22748869
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18420258
130Hedgehog signaling pathway_Homo sapiens_hsa043400.14693342
131Estrogen signaling pathway_Homo sapiens_hsa049150.13924890
132Propanoate metabolism_Homo sapiens_hsa006400.11345232
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09697090
134Hippo signaling pathway_Homo sapiens_hsa043900.09036127
135Retinol metabolism_Homo sapiens_hsa008300.08500765

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