OVOL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)9.51610701
2sphingoid metabolic process (GO:0046519)8.87292792
3synapsis (GO:0007129)8.81081758
4meiotic chromosome segregation (GO:0045132)8.42615347
5chromosome organization involved in meiosis (GO:0070192)8.20345632
6male meiosis I (GO:0007141)8.17948381
7synaptonemal complex assembly (GO:0007130)7.62253961
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.40821330
9L-phenylalanine catabolic process (GO:0006559)7.40821330
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.31503346
11L-phenylalanine metabolic process (GO:0006558)7.31503346
12regulation of odontogenesis of dentin-containing tooth (GO:0042487)6.88194910
13synaptonemal complex organization (GO:0070193)6.81156409
14meiosis I (GO:0007127)6.72861286
15aromatic amino acid family catabolic process (GO:0009074)6.69625837
16DNA synthesis involved in DNA repair (GO:0000731)6.46498835
17male meiosis (GO:0007140)6.42678707
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.19915420
19indole-containing compound catabolic process (GO:0042436)6.01285627
20indolalkylamine catabolic process (GO:0046218)6.01285627
21tryptophan catabolic process (GO:0006569)6.01285627
22kynurenine metabolic process (GO:0070189)5.98810260
23meiotic nuclear division (GO:0007126)5.97759204
24bile acid biosynthetic process (GO:0006699)5.94895534
25urea cycle (GO:0000050)5.94670914
26urea metabolic process (GO:0019627)5.94670914
27glyoxylate metabolic process (GO:0046487)5.83328383
28negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.81684327
29tryptophan metabolic process (GO:0006568)5.61535528
30high-density lipoprotein particle remodeling (GO:0034375)5.57306069
31sulfur amino acid catabolic process (GO:0000098)5.51623463
32negative regulation of fibrinolysis (GO:0051918)5.48604842
33lipopolysaccharide biosynthetic process (GO:0009103)5.48365103
34reciprocal DNA recombination (GO:0035825)5.46659563
35reciprocal meiotic recombination (GO:0007131)5.46659563
36protein-chromophore linkage (GO:0018298)5.43943516
37nitrogen cycle metabolic process (GO:0071941)5.42408995
38paraxial mesoderm development (GO:0048339)5.37980840
39positive regulation of meiotic cell cycle (GO:0051446)5.36066715
40meiotic cell cycle process (GO:1903046)5.34328695
41cysteine metabolic process (GO:0006534)5.32983163
42serine family amino acid catabolic process (GO:0009071)5.29504963
43negative regulation of cell cycle G2/M phase transition (GO:1902750)5.13986310
44regulation of fibrinolysis (GO:0051917)5.10146218
45sister chromatid cohesion (GO:0007062)5.06872086
46homocysteine metabolic process (GO:0050667)5.04560934
47glycine metabolic process (GO:0006544)5.03370838
48bile acid metabolic process (GO:0008206)4.99255460
49positive regulation of meiosis (GO:0045836)4.97639336
50aromatic amino acid family metabolic process (GO:0009072)4.96251372
51regulation of protein activation cascade (GO:2000257)4.95772738
52regulation of triglyceride catabolic process (GO:0010896)4.94705935
53negative regulation of cholesterol transport (GO:0032375)4.92029897
54negative regulation of sterol transport (GO:0032372)4.92029897
55centriole replication (GO:0007099)4.91789803
56regulation of cholesterol esterification (GO:0010872)4.89667358
57alpha-linolenic acid metabolic process (GO:0036109)4.88879008
58complement activation, alternative pathway (GO:0006957)4.88662538
59peptidyl-glutamic acid carboxylation (GO:0017187)4.84685129
60protein carboxylation (GO:0018214)4.84685129
61tyrosine metabolic process (GO:0006570)4.80520425
62reverse cholesterol transport (GO:0043691)4.65466664
63regulation of complement activation (GO:0030449)4.64120287
64protein-lipid complex remodeling (GO:0034368)4.60866959
65macromolecular complex remodeling (GO:0034367)4.60866959
66plasma lipoprotein particle remodeling (GO:0034369)4.60866959
67lipopolysaccharide metabolic process (GO:0008653)4.57419874
68fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.57104320
69phospholipid efflux (GO:0033700)4.56324444
70alpha-amino acid catabolic process (GO:1901606)4.56279978
71serine family amino acid metabolic process (GO:0009069)4.51336703
72serine family amino acid biosynthetic process (GO:0009070)4.50870465
73regulation of nuclear cell cycle DNA replication (GO:0033262)4.46883746
74amino-acid betaine metabolic process (GO:0006577)4.43994728
75triglyceride homeostasis (GO:0070328)4.43576293
76acylglycerol homeostasis (GO:0055090)4.43576293
77sulfate transmembrane transport (GO:1902358)4.40924374
78coenzyme catabolic process (GO:0009109)4.40532832
79gene silencing by RNA (GO:0031047)4.40376006
80plasma lipoprotein particle clearance (GO:0034381)4.39140202
81negative regulation of glycoprotein biosynthetic process (GO:0010561)4.37741455
82DNA alkylation (GO:0006305)4.37452154
83DNA methylation (GO:0006306)4.37452154
84lysine metabolic process (GO:0006553)4.36606987
85lysine catabolic process (GO:0006554)4.36606987
86female gamete generation (GO:0007292)4.27740924
87cholesterol efflux (GO:0033344)4.18118871
88cellular amino acid catabolic process (GO:0009063)4.15535517
89regulation of pigment cell differentiation (GO:0050932)4.14970213
90indolalkylamine metabolic process (GO:0006586)4.14231369
91plasma lipoprotein particle assembly (GO:0034377)4.13899940
92complement activation, classical pathway (GO:0006958)4.11634285
93arginine metabolic process (GO:0006525)4.11627111
94imidazole-containing compound metabolic process (GO:0052803)4.08750487
95amine catabolic process (GO:0009310)4.07717606
96cellular biogenic amine catabolic process (GO:0042402)4.07717606
97positive regulation of developmental pigmentation (GO:0048087)4.07063483
98regulation of protein glycosylation (GO:0060049)4.04670356
99centriole assembly (GO:0098534)4.00744494
100sulfate transport (GO:0008272)4.00460933
101regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.00052463
102regulation of cytokine secretion involved in immune response (GO:0002739)3.98004247
103notochord development (GO:0030903)3.97710779
104benzene-containing compound metabolic process (GO:0042537)3.96987793
105regulation of DNA endoreduplication (GO:0032875)3.96418603
106bile acid and bile salt transport (GO:0015721)3.93421739
107cellular ketone body metabolic process (GO:0046950)3.92705568
108meiotic cell cycle (GO:0051321)3.92330608
109cellular glucuronidation (GO:0052695)3.91504398
110heme transport (GO:0015886)3.90738889
111positive regulation of lipoprotein lipase activity (GO:0051006)3.87385411
112positive regulation of triglyceride lipase activity (GO:0061365)3.87385411
113dicarboxylic acid biosynthetic process (GO:0043650)3.85371788
114complement activation (GO:0006956)3.84044921
115aldehyde catabolic process (GO:0046185)3.83894208
116cellular modified amino acid catabolic process (GO:0042219)3.83734008
117negative regulation of lipase activity (GO:0060192)3.83307360
118acetyl-CoA metabolic process (GO:0006084)3.81942998
119midgut development (GO:0007494)3.81602048
120glutamate metabolic process (GO:0006536)3.80470254
121protein-lipid complex assembly (GO:0065005)3.74603747
122negative regulation of fatty acid biosynthetic process (GO:0045717)3.73955616
123one-carbon metabolic process (GO:0006730)3.73056528
124very-low-density lipoprotein particle assembly (GO:0034379)3.71837989
125L-serine metabolic process (GO:0006563)3.69121233
126histone H3-K36 demethylation (GO:0070544)3.68986899
127fibrinolysis (GO:0042730)3.68828204
128regulation of cholesterol homeostasis (GO:2000188)3.67980240
129regulation of bile acid biosynthetic process (GO:0070857)3.67458244
130ethanol oxidation (GO:0006069)3.62263587
131cholesterol homeostasis (GO:0042632)3.61070275
132cofactor catabolic process (GO:0051187)3.60488261
133protein activation cascade (GO:0072376)3.57512580
134carboxylic acid catabolic process (GO:0046395)3.55558816
135organic acid catabolic process (GO:0016054)3.55558816
136cytolysis (GO:0019835)3.53997230
137sterol homeostasis (GO:0055092)3.52964349
138plasma lipoprotein particle organization (GO:0071827)3.51837503
139genitalia morphogenesis (GO:0035112)3.50410572
140ketone body metabolic process (GO:1902224)3.47759567
141regulation of meiotic cell cycle (GO:0051445)3.45688749
142low-density lipoprotein particle remodeling (GO:0034374)3.44814228
143phospholipid homeostasis (GO:0055091)3.43553877
144positive regulation of lipid catabolic process (GO:0050996)3.41266426
145blood coagulation, intrinsic pathway (GO:0007597)3.41009439
146somite rostral/caudal axis specification (GO:0032525)3.30779816
147pantothenate metabolic process (GO:0015939)3.29554951
148negative regulation of chromosome segregation (GO:0051985)3.29333493
149mitotic spindle checkpoint (GO:0071174)3.25415573
150sex differentiation (GO:0007548)3.23053155
151oogenesis (GO:0048477)3.20293191
152mitotic spindle assembly checkpoint (GO:0007094)3.19963116
153negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19674515
154negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.19674515
155negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19674515
156negative regulation of mitotic sister chromatid separation (GO:2000816)3.19674515
157negative regulation of sister chromatid segregation (GO:0033046)3.19674515
158DNA methylation or demethylation (GO:0044728)3.13246785
159resolution of meiotic recombination intermediates (GO:0000712)3.12959781
160spindle assembly checkpoint (GO:0071173)3.11384049
161negative regulation of DNA-dependent DNA replication (GO:2000104)3.11048237
162vitamin transmembrane transport (GO:0035461)3.08034627
163mitotic chromosome condensation (GO:0007076)3.05513242
164ribonucleoprotein complex disassembly (GO:0032988)3.05099005
165regulation of transcription from RNA polymerase I promoter (GO:0006356)3.04366219
166negative regulation of glycoprotein metabolic process (GO:1903019)3.02710315
167spindle checkpoint (GO:0031577)3.00965080
168regulation of odontogenesis (GO:0042481)2.99513360
169nodal signaling pathway (GO:0038092)2.97421644
170SMAD protein complex assembly (GO:0007183)2.97388724
171interkinetic nuclear migration (GO:0022027)2.96294997
172protein localization to chromosome (GO:0034502)2.95218553
173histone H3-K9 demethylation (GO:0033169)2.94484675
174epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.94387222
175regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92300505
176regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92300505
177spermatid development (GO:0007286)2.89876697
178regulation of meiosis (GO:0040020)2.88387078
179regulation of sister chromatid segregation (GO:0033045)2.87255010
180regulation of mitotic sister chromatid separation (GO:0010965)2.87255010
181regulation of mitotic sister chromatid segregation (GO:0033047)2.87255010
182cellular response to gamma radiation (GO:0071480)2.79784199
183DNA modification (GO:0006304)2.79049462
184biotin metabolic process (GO:0006768)2.78099291
185DNA damage induced protein phosphorylation (GO:0006975)2.75775564
186negative regulation of gene silencing (GO:0060969)2.75164729
187regulation of translational termination (GO:0006449)2.74864417
188maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72808183
189protein retention in ER lumen (GO:0006621)2.72760073
190regulation of transforming growth factor beta2 production (GO:0032909)2.72628566
191serotonin receptor signaling pathway (GO:0007210)2.71814347
192DNA methylation involved in gamete generation (GO:0043046)11.3064241
193sphingosine metabolic process (GO:0006670)11.2925555
194piRNA metabolic process (GO:0034587)11.1678847
195diol metabolic process (GO:0034311)10.1417967

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.45291780
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.40281384
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.39785452
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.54242862
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.95499926
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.56329543
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.52366781
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.07975628
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.99130401
10AR_21572438_ChIP-Seq_LNCaP_Human3.75025333
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.68478763
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.58917506
13IGF1R_20145208_ChIP-Seq_DFB_Human3.38297066
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.37566767
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.15320841
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.64948375
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.39475821
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.18327988
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06967295
20POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06717497
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8066885
22E2F1_21310950_ChIP-Seq_MCF-7_Human1.93032792
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92769782
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91653512
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.88292715
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.86466570
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.86250495
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84593916
29ZNF274_21170338_ChIP-Seq_K562_Hela1.82754199
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80318603
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79837066
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77887442
33GABP_19822575_ChIP-Seq_HepG2_Human1.71433947
34AR_21909140_ChIP-Seq_LNCAP_Human1.68966596
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.68283577
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67558766
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.65981776
38HOXB7_26014856_ChIP-Seq_BT474_Human1.62284676
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60243339
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58913502
41STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.56688334
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52870808
43CLOCK_20551151_ChIP-Seq_293T_Human1.46814516
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45812808
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42141418
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41635324
47ER_23166858_ChIP-Seq_MCF-7_Human1.40261744
48FOXP3_21729870_ChIP-Seq_TREG_Human1.40232305
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38427121
50OCT4_20526341_ChIP-Seq_ESCs_Human1.36564109
51E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.35512876
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35059493
53TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.34203248
54RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.33465870
55EGR1_19032775_ChIP-ChIP_M12_Human1.33382901
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31412211
57STAT1_20625510_ChIP-Seq_HELA_Human1.27896684
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.27026370
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26885436
60PHF8_20622854_ChIP-Seq_HELA_Human1.25351792
61CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24330387
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.23253807
63RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22545551
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22522665
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21415567
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21412118
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21225483
68SMC4_20622854_ChIP-Seq_HELA_Human1.20365720
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20363811
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20027024
71FOXA2_19822575_ChIP-Seq_HepG2_Human1.20005942
72HNF4A_19822575_ChIP-Seq_HepG2_Human1.19900595
73ERA_21632823_ChIP-Seq_H3396_Human1.19080639
74E2F1_20622854_ChIP-Seq_HELA_Human1.19008950
75ZNF263_19887448_ChIP-Seq_K562_Human1.18203499
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18017786
77P68_20966046_ChIP-Seq_HELA_Human1.09313995
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08955308
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.08225120
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08149778
81VDR_23849224_ChIP-Seq_CD4+_Human1.07316583
82GATA3_26560356_Chip-Seq_TH1_Human1.06623272
83YY1_22570637_ChIP-Seq_MALME-3M_Human1.06612882
84GATA3_21867929_ChIP-Seq_TH1_Mouse1.05698297
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05177608
86EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04162443
87HTT_18923047_ChIP-ChIP_STHdh_Human1.02177723
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02063456
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01454811
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00155033
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99264451
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.98456320
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98091110
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.97958949
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97958949
96STAT3_18555785_ChIP-Seq_MESCs_Mouse0.97757236
97P53_21459846_ChIP-Seq_SAOS-2_Human0.97392901
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96620701
99SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95490923
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95108920
101MYC_19829295_ChIP-Seq_ESCs_Human0.94324079
102NANOG_19829295_ChIP-Seq_ESCs_Human0.93403832
103SOX2_19829295_ChIP-Seq_ESCs_Human0.93403832
104NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91870174
105SOX2_21211035_ChIP-Seq_LN229_Human0.90959128
106RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90652859
107LXR_22292898_ChIP-Seq_THP-1_Human0.90648105
108OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90131354
109NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90016452
110RARA_24833708_ChIP-Seq_LIVER_Mouse0.89371326
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89349527
112NCOR_22424771_ChIP-Seq_293T_Human0.88771341
113TTF2_22483619_ChIP-Seq_HELA_Human0.88476154
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87768753
115STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86555440
116ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85874969
117RAC3_21632823_ChIP-Seq_H3396_Human0.85094474
118SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84612612
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84278792
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83576981
121E2F1_17053090_ChIP-ChIP_MCF-7_Human0.83544701
122ELK1_22589737_ChIP-Seq_MCF10A_Human0.83501048
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.82927672
124RARB_24833708_ChIP-Seq_LIVER_Mouse0.82922434
125EST1_17652178_ChIP-ChIP_JURKAT_Human0.82658946
126CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82581451
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.81941000
128LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81933145
129LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.81847147
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81455968
131SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79565230
132E2F7_22180533_ChIP-Seq_HELA_Human0.79338438
133MYC_18555785_ChIP-Seq_MESCs_Mouse0.78221875
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77032858
135MYC_18358816_ChIP-ChIP_MESCs_Mouse0.76508388
136RACK7_27058665_Chip-Seq_MCF-7_Human0.76436727
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76210839
138E2F1_18555785_ChIP-Seq_MESCs_Mouse0.76135943
139KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73122705
140XRN2_22483619_ChIP-Seq_HELA_Human0.72073539
141SOX2_18692474_ChIP-Seq_MESCs_Mouse0.71685325
142NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.71041299
143RARG_19884340_ChIP-ChIP_MEFs_Mouse0.66105547
144ESR1_15608294_ChIP-ChIP_MCF-7_Human0.65404405
145KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.65232762
146TP63_17297297_ChIP-ChIP_HaCaT_Human0.63595909
147TCF3_18692474_ChIP-Seq_MESCs_Mouse0.63444433
148MYC_22102868_ChIP-Seq_BL_Human0.63106316
149SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63085387
150SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.61682656
151E2F4_17652178_ChIP-ChIP_JURKAT_Human0.61327988
152POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.61006594
153TET1_21451524_ChIP-Seq_MESCs_Mouse0.60437921
154TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.60159340
155BCOR_27268052_Chip-Seq_Bcells_Human0.59890973
156PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.58987567
157POU5F1_16518401_ChIP-PET_MESCs_Mouse0.58517225
158SRY_22984422_ChIP-ChIP_TESTIS_Rat0.58349629
159KDM5A_27292631_Chip-Seq_BREAST_Human0.57957849
160NANOG_18692474_ChIP-Seq_MEFs_Mouse0.57732992
161PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.57059291
162FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.56489485
163MYC_19030024_ChIP-ChIP_MESCs_Mouse0.56456858
164GATA4_25053715_ChIP-Seq_YYC3_Human0.55170360
165ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.55098639
166RAD21_21589869_ChIP-Seq_MESCs_Mouse0.54872525
167CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.54776697
168KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.54460422
169ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.54093241
170VDR_21846776_ChIP-Seq_THP-1_Human0.52509522
171RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.52280174
172GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.51994681
173NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.51705132
174MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.51645453
175ATF3_27146783_Chip-Seq_COLON_Human0.51402800
176NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.51307105
177NELFA_20434984_ChIP-Seq_ESCs_Mouse0.51187690
178GATA6_25053715_ChIP-Seq_YYC3_Human0.50805324
179CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.50510446
180SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.50308391
181DCP1A_22483619_ChIP-Seq_HELA_Human0.50001633
182MYC_19079543_ChIP-ChIP_MESCs_Mouse0.49653087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.16309512
2MP0005360_urolithiasis7.37708970
3MP0003136_yellow_coat_color6.93925417
4MP0005171_absent_coat_pigmentation6.80825520
5MP0002837_dystrophic_cardiac_calcinosis6.72897709
6MP0005085_abnormal_gallbladder_physiolo6.26663046
7MP0005365_abnormal_bile_salt6.21477326
8MP0003806_abnormal_nucleotide_metabolis4.53748202
9MP0008875_abnormal_xenobiotic_pharmacok4.52672548
10MP0003890_abnormal_embryonic-extraembry4.45920117
11MP0003646_muscle_fatigue4.25498203
12MP0009840_abnormal_foam_cell3.86758269
13MP0003252_abnormal_bile_duct3.61179587
14MP0000569_abnormal_digit_pigmentation3.55119649
15MP0008877_abnormal_DNA_methylation3.54335607
16MP0010329_abnormal_lipoprotein_level3.34180235
17MP0003045_fibrosis2.88000744
18MP0005332_abnormal_amino_acid2.79982723
19MP0003195_calcinosis2.76830894
20MP0002160_abnormal_reproductive_system2.74014470
21MP0005083_abnormal_biliary_tract2.69978757
22MP0001666_abnormal_nutrient_absorption2.48194110
23MP0002210_abnormal_sex_determination2.18988281
24MP0000609_abnormal_liver_physiology2.12579927
25MP0003191_abnormal_cellular_cholesterol2.12418123
26MP0005174_abnormal_tail_pigmentation2.10017699
27MP0003879_abnormal_hair_cell2.03587603
28MP0009053_abnormal_anal_canal2.02330037
29MP0010094_abnormal_chromosome_stability2.02021363
30MP0005451_abnormal_body_composition1.99778324
31MP0004019_abnormal_vitamin_homeostasis1.94206406
32MP0002118_abnormal_lipid_homeostasis1.93255651
33MP0008058_abnormal_DNA_repair1.90805450
34MP0000749_muscle_degeneration1.84548844
35MP0002938_white_spotting1.83556562
36MP0003868_abnormal_feces_composition1.78793869
37MP0002138_abnormal_hepatobiliary_system1.75747916
38MP0001929_abnormal_gametogenesis1.71013638
39MP0000015_abnormal_ear_pigmentation1.69845535
40MP0001764_abnormal_homeostasis1.62781059
41MP0005319_abnormal_enzyme/_coenzyme1.62153211
42MP0005075_abnormal_melanosome_morpholog1.58440489
43MP0001145_abnormal_male_reproductive1.57984568
44MP0005389_reproductive_system_phenotype1.51885589
45MP0002075_abnormal_coat/hair_pigmentati1.48504852
46MP0004233_abnormal_muscle_weight1.46434297
47MP0003698_abnormal_male_reproductive1.45839295
48MP0002095_abnormal_skin_pigmentation1.43400493
49MP0005584_abnormal_enzyme/coenzyme_acti1.42844654
50MP0000427_abnormal_hair_cycle1.41068326
51MP0000653_abnormal_sex_gland1.40529627
52MP0001986_abnormal_taste_sensitivity1.28216158
53MP0008995_early_reproductive_senescence1.26546547
54MP0000598_abnormal_liver_morphology1.24352967
55MP0004147_increased_porphyrin_level1.24016465
56MP0003705_abnormal_hypodermis_morpholog1.21970883
57MP0009643_abnormal_urine_homeostasis1.18686445
58MP0008007_abnormal_cellular_replicative1.17240143
59MP0008057_abnormal_DNA_replication1.16642389
60MP0003718_maternal_effect1.13905069
61MP0003186_abnormal_redox_activity1.13114990
62MP0003786_premature_aging1.11872667
63MP0008932_abnormal_embryonic_tissue1.11334795
64MP0001186_pigmentation_phenotype1.11023436
65MP0003937_abnormal_limbs/digits/tail_de1.10647166
66MP0003693_abnormal_embryo_hatching1.02633699
67MP0002254_reproductive_system_inflammat1.02129782
68MP0002269_muscular_atrophy1.01972278
69MP0000383_abnormal_hair_follicle1.01841293
70MP0005330_cardiomyopathy0.99801564
71MP0001984_abnormal_olfaction0.97229581
72MP0005408_hypopigmentation0.96327629
73MP0005220_abnormal_exocrine_pancreas0.95190538
74MP0010352_gastrointestinal_tract_polyps0.93233455
75MP0004264_abnormal_extraembryonic_tissu0.93219708
76MP0009763_increased_sensitivity_to0.93156725
77MP0003011_delayed_dark_adaptation0.92827345
78MP0009697_abnormal_copulation0.92282410
79MP0005076_abnormal_cell_differentiation0.91828323
80MP0000604_amyloidosis0.90318362
81MP0005670_abnormal_white_adipose0.85558564
82MP0002161_abnormal_fertility/fecundity0.81840727
83MP0000579_abnormal_nail_morphology0.80570560
84MP0003283_abnormal_digestive_organ0.80212738
85MP0005647_abnormal_sex_gland0.79199706
86MP0002282_abnormal_trachea_morphology0.78487065
87MP0001324_abnormal_eye_pigmentation0.77786235
88MP0005376_homeostasis/metabolism_phenot0.77707103
89MP0005499_abnormal_olfactory_system0.76877027
90MP0005394_taste/olfaction_phenotype0.76877027
91MP0005266_abnormal_metabolism0.75395133
92MP0000566_synostosis0.74821119
93MP0005395_other_phenotype0.71555888
94MP0009642_abnormal_blood_homeostasis0.71376886
95MP0005409_darkened_coat_color0.71100014
96MP0008469_abnormal_protein_level0.70560099
97MP0004381_abnormal_hair_follicle0.70201456
98MP0003656_abnormal_erythrocyte_physiolo0.70008380
99MP0009764_decreased_sensitivity_to0.69909966
100MP0002084_abnormal_developmental_patter0.68364314
101MP0005423_abnormal_somatic_nervous0.66454434
102MP0005636_abnormal_mineral_homeostasis0.65697976
103MP0009672_abnormal_birth_weight0.64745869
104MP0000639_abnormal_adrenal_gland0.63893694
105MP0003959_abnormal_lean_body0.63393811
106MP0000537_abnormal_urethra_morphology0.63011349
107MP0009765_abnormal_xenobiotic_induced0.62118858
108MP0001697_abnormal_embryo_size0.60607226
109MP0002078_abnormal_glucose_homeostasis0.60001777
110MP0008770_decreased_survivor_rate0.59357388
111MP0005084_abnormal_gallbladder_morpholo0.58321461
112MP0006036_abnormal_mitochondrial_physio0.57822301
113MP0003137_abnormal_impulse_conducting0.57795313
114MP0010678_abnormal_skin_adnexa0.57768448
115MP0008789_abnormal_olfactory_epithelium0.57741853
116MP0003453_abnormal_keratinocyte_physiol0.57637442
117MP0008961_abnormal_basal_metabolism0.56808313
118MP0003878_abnormal_ear_physiology0.54915187
119MP0005377_hearing/vestibular/ear_phenot0.54915187
120MP0005380_embryogenesis_phenotype0.53866165
121MP0001672_abnormal_embryogenesis/_devel0.53866165
122MP0002735_abnormal_chemical_nociception0.53136701
123MP0000534_abnormal_ureter_morphology0.52740571
124MP0005023_abnormal_wound_healing0.51876492
125MP0003329_amyloid_beta_deposits0.51286659
126MP0000538_abnormal_urinary_bladder0.51034544
127MP0002971_abnormal_brown_adipose0.49909194
128MP0000647_abnormal_sebaceous_gland0.49640119
129MP0005410_abnormal_fertilization0.49484993
130MP0000377_abnormal_hair_follicle0.48414660
131MP0003111_abnormal_nucleus_morphology0.47920059
132MP0008873_increased_physiological_sensi0.46481102
133MP0001756_abnormal_urination0.45785353
134MP0003385_abnormal_body_wall0.44371411
135MP0000367_abnormal_coat/_hair0.43309657
136MP0003763_abnormal_thymus_physiology0.43257780
137MP0002136_abnormal_kidney_physiology0.43175319
138MP0004957_abnormal_blastocyst_morpholog0.42745229
139MP0010368_abnormal_lymphatic_system0.42257669
140MP0010234_abnormal_vibrissa_follicle0.41859463
141MP0003699_abnormal_female_reproductive0.41718155
142MP0003943_abnormal_hepatobiliary_system0.41204709
143MP0001944_abnormal_pancreas_morphology0.40953648
144MP0002085_abnormal_embryonic_tissue0.40506840
145MP0003936_abnormal_reproductive_system0.40432413
146MP0005334_abnormal_fat_pad0.40032644
147MP0002928_abnormal_bile_duct0.39772206
148MP0003183_abnormal_peptide_metabolism0.39425493
149MP0003119_abnormal_digestive_system0.38584457
150MP0003115_abnormal_respiratory_system0.38218744
151MP0002009_preneoplasia0.37542115
152MP0010307_abnormal_tumor_latency0.36467228
153MP0000358_abnormal_cell_content/0.36250882
154MP0002080_prenatal_lethality0.35636948
155MP0000678_abnormal_parathyroid_gland0.35482122
156MP0006054_spinal_hemorrhage0.35237506
157MP0001661_extended_life_span0.35200103
158MP0001915_intracranial_hemorrhage0.32807971
159MP0004133_heterotaxia0.32128128
160MP0003077_abnormal_cell_cycle0.31819507
161MP0002970_abnormal_white_adipose0.31161156
162MP0002653_abnormal_ependyma_morphology0.29547092
163MP0001243_abnormal_dermal_layer0.28748458
164MP0001119_abnormal_female_reproductive0.28221504
165MP0005666_abnormal_adipose_tissue0.27857892
166MP0002111_abnormal_tail_morphology0.27811433
167MP0000371_diluted_coat_color0.27245866
168MP0000467_abnormal_esophagus_morphology0.26893982
169MP0002089_abnormal_postnatal_growth/wei0.26093949
170MP0002932_abnormal_joint_morphology0.24804123
171MP0003436_decreased_susceptibility_to0.24760431
172MP0006035_abnormal_mitochondrial_morpho0.24435491
173MP0001730_embryonic_growth_arrest0.24370093
174MP0005464_abnormal_platelet_physiology0.23635930
175MP0002168_other_aberrant_phenotype0.23617881
176MP0003303_peritoneal_inflammation0.23554643
177MP0003638_abnormal_response/metabolism_0.22874498
178MP0003075_altered_response_to0.21449099

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)7.71478010
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.50971562
3Deep venous thrombosis (HP:0002625)7.31723626
4Intrahepatic cholestasis (HP:0001406)7.24747639
5Abnormality of monocarboxylic acid metabolism (HP:0010996)7.13945421
6Hypobetalipoproteinemia (HP:0003563)6.76517273
7Xanthomatosis (HP:0000991)6.40069278
8Focal motor seizures (HP:0011153)6.26601700
9Prolonged partial thromboplastin time (HP:0003645)5.81697465
10Hyperlipoproteinemia (HP:0010980)5.63060816
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.60792834
12Hypolipoproteinemia (HP:0010981)5.01195546
13Complement deficiency (HP:0004431)4.99758656
14Abnormality of sulfur amino acid metabolism (HP:0004339)4.77648933
15Aplasia/Hypoplasia of the uvula (HP:0010293)4.76846890
16Abnormality of methionine metabolism (HP:0010901)4.70497070
17Chromosomal breakage induced by crosslinking agents (HP:0003221)4.65226889
18Hyperammonemia (HP:0001987)4.63090596
19Epidermoid cyst (HP:0200040)4.59311537
20Type I transferrin isoform profile (HP:0003642)4.58212337
21Abnormality of pyrimidine metabolism (HP:0004353)4.57834103
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.48367742
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.44453189
24Hypoalphalipoproteinemia (HP:0003233)4.37171214
25Joint hemorrhage (HP:0005261)4.36292304
26Hyperglycinemia (HP:0002154)4.32806309
27Aplastic anemia (HP:0001915)4.30137483
28Ketosis (HP:0001946)4.27533974
29Vertebral arch anomaly (HP:0008438)4.25450083
30Parakeratosis (HP:0001036)4.24142363
31Abnormality of glutamine family amino acid metabolism (HP:0010902)4.07108262
32Horizontal nystagmus (HP:0000666)4.03011900
33Chromsome breakage (HP:0040012)3.97751168
34Abnormality of the common coagulation pathway (HP:0010990)3.94521093
35Abnormal protein glycosylation (HP:0012346)3.92543008
36Abnormal glycosylation (HP:0012345)3.92543008
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.92543008
38Abnormal protein N-linked glycosylation (HP:0012347)3.92543008
39Gonadotropin excess (HP:0000837)3.91728895
40Hyperglycinuria (HP:0003108)3.90726292
41Abnormality of glycine metabolism (HP:0010895)3.85330648
42Abnormality of serine family amino acid metabolism (HP:0010894)3.85330648
43Colon cancer (HP:0003003)3.82733515
44Fat malabsorption (HP:0002630)3.80821537
45Hypoglycemic coma (HP:0001325)3.75185933
46Abnormality of complement system (HP:0005339)3.74923874
47Overlapping toe (HP:0001845)3.66304693
48Abnormality of nucleobase metabolism (HP:0010932)3.40208278
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37303832
50Dialeptic seizures (HP:0011146)3.32759996
51Congenital ichthyosiform erythroderma (HP:0007431)3.32481564
52Abnormality of the intrinsic pathway (HP:0010989)3.31529862
53Delayed CNS myelination (HP:0002188)3.25089776
54Hypercholesterolemia (HP:0003124)3.22631516
55Ketoacidosis (HP:0001993)3.21959314
56Abnormality of serum amino acid levels (HP:0003112)3.16570716
57Abnormality of fatty-acid metabolism (HP:0004359)3.14542963
58Scapular winging (HP:0003691)3.11208871
59Proximal amyotrophy (HP:0007126)3.10635043
6011 pairs of ribs (HP:0000878)3.04660986
61Hyperbilirubinemia (HP:0002904)2.94550370
62Non-midline cleft lip (HP:0100335)2.89736846
63Gout (HP:0001997)2.85833316
64Ulnar bowing (HP:0003031)2.85058227
65Myocardial infarction (HP:0001658)2.83004622
66Spastic diplegia (HP:0001264)2.81684922
67Abnormality of purine metabolism (HP:0004352)2.81395366
68Steatorrhea (HP:0002570)2.81334061
69Conjugated hyperbilirubinemia (HP:0002908)2.81053542
70Rectal prolapse (HP:0002035)2.78937339
71Hypoplastic iliac wings (HP:0002866)2.78197653
72Skin nodule (HP:0200036)2.77477979
73Oligodactyly (hands) (HP:0001180)2.76816755
74Hepatocellular carcinoma (HP:0001402)2.71517889
75Cerebellar dysplasia (HP:0007033)2.70690376
76Spontaneous abortion (HP:0005268)2.69369908
77Severe visual impairment (HP:0001141)2.61805192
78Lethargy (HP:0001254)2.60734323
79Erythroderma (HP:0001019)2.57697898
80Metabolic acidosis (HP:0001942)2.57431391
81Hypochromic microcytic anemia (HP:0004840)2.57185500
82Pendular nystagmus (HP:0012043)2.54233306
83Difficulty walking (HP:0002355)2.53572446
84Abnormality of cochlea (HP:0000375)2.51490282
85Pancreatic cysts (HP:0001737)2.51019109
86Volvulus (HP:0002580)2.47338139
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.45955832
88Dicarboxylic aciduria (HP:0003215)2.45955832
89Abnormality of the vocal cords (HP:0008777)2.43266157
90Neonatal onset (HP:0003623)2.41380727
91Duplicated collecting system (HP:0000081)2.38383075
92Systemic lupus erythematosus (HP:0002725)2.34663702
93Abnormality of the shoulder girdle musculature (HP:0001435)2.34163208
94Recurrent gram-negative bacterial infections (HP:0005420)2.33304045
95Vascular calcification (HP:0004934)2.32527419
96Carpal bone hypoplasia (HP:0001498)2.28681137
97Irritability (HP:0000737)2.28280007
98Abnormal gallbladder morphology (HP:0012437)2.28088808
99Brushfield spots (HP:0001088)2.27651777
100Malnutrition (HP:0004395)2.27044727
101Late onset (HP:0003584)2.25286271
102Conjunctival telangiectasia (HP:0000524)2.24901378
103Microvesicular hepatic steatosis (HP:0001414)2.23806666
104Cholelithiasis (HP:0001081)2.22735508
105Radial bowing (HP:0002986)2.22462918
106Oligodactyly (HP:0012165)2.21248682
107Ectopic kidney (HP:0000086)2.20750581
108Esophageal varix (HP:0002040)2.20252125
109Synostosis of carpal bones (HP:0005048)2.20152235
110Abnormality of chromosome stability (HP:0003220)2.19755605
111Opisthotonus (HP:0002179)2.16782734
112Gingival bleeding (HP:0000225)2.15513354
113Mitral stenosis (HP:0001718)2.15386759
114Meckel diverticulum (HP:0002245)2.15381256
115Abnormality of the renal medulla (HP:0100957)2.13814929
116Cerebral edema (HP:0002181)2.13212916
117Abnormality of the ileum (HP:0001549)2.13137288
118Abnormality of the renal collecting system (HP:0004742)2.12950875
119Increased purine levels (HP:0004368)2.11426555
120Hyperuricemia (HP:0002149)2.11426555
121Abnormality of macular pigmentation (HP:0008002)2.08813287
122Hypoglycemic seizures (HP:0002173)2.08127743
123Small intestinal stenosis (HP:0012848)2.06812230
124Duodenal stenosis (HP:0100867)2.06812230
125Aortic valve stenosis (HP:0001650)2.04650777
126Acanthocytosis (HP:0001927)2.04488401
127Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03597335
128Cardiovascular calcification (HP:0011915)2.02813417
129Ulnar claw (HP:0001178)2.01639254
130Abnormality of the preputium (HP:0100587)2.00981593
131Turricephaly (HP:0000262)1.99442673
132Azoospermia (HP:0000027)1.98431539
133Abnormal gallbladder physiology (HP:0012438)1.95684629
134Cholecystitis (HP:0001082)1.95684629
135Hyperglycemia (HP:0003074)1.94811149
136Glomerulonephritis (HP:0000099)1.94379894
137Spontaneous hematomas (HP:0007420)1.93824482
138Progressive inability to walk (HP:0002505)1.93170919
139Retinitis pigmentosa (HP:0000510)1.92246363
140Facial hemangioma (HP:0000329)1.91788353
141Focal seizures (HP:0007359)1.91482344
142Vomiting (HP:0002013)1.90610667
143Pancytopenia (HP:0001876)1.89912485
144Birth length less than 3rd percentile (HP:0003561)1.89876461
145Nephronophthisis (HP:0000090)1.89630042
146Abnormality of the Achilles tendon (HP:0005109)1.89519512
147Menorrhagia (HP:0000132)1.88198881
148Alkalosis (HP:0001948)1.87933924
149Neoplasm of the colon (HP:0100273)1.87422709
150Hyperinsulinemic hypoglycemia (HP:0000825)1.87412200
151Abnormality of iron homeostasis (HP:0011031)1.85882656
152Tubular atrophy (HP:0000092)1.85630755
153Abnormality of DNA repair (HP:0003254)1.85269479
154Abnormality of transition element cation homeostasis (HP:0011030)1.84958705
155Abnormal cartilage morphology (HP:0002763)1.84782830
156Amyloidosis (HP:0011034)1.83606882
157Abnormality of the fingertips (HP:0001211)1.83292291
158Broad distal phalanx of finger (HP:0009836)1.82741725
159Type II lissencephaly (HP:0007260)1.82692753
160Abnormality of the renal cortex (HP:0011035)1.82318687
161Tubulointerstitial nephritis (HP:0001970)1.81878620
162Diastasis recti (HP:0001540)1.79843982
163Sloping forehead (HP:0000340)1.78711463
164Clubbing of toes (HP:0100760)1.75858041
165Hypoplastic pelvis (HP:0008839)1.75547170
166Abnormality of the gallbladder (HP:0005264)1.75047849
167Cystic liver disease (HP:0006706)1.74993957
168Pancreatitis (HP:0001733)1.74657523
169Thrombophlebitis (HP:0004418)1.73975799
170Abnormal spermatogenesis (HP:0008669)1.73697889
171Hematochezia (HP:0002573)1.72186184
172Back pain (HP:0003418)1.72082939
173Neonatal respiratory distress (HP:0002643)1.71303145
174Oral leukoplakia (HP:0002745)1.70068018
175Bowing of the arm (HP:0006488)1.69634714
176Bowed forearm bones (HP:0003956)1.69634714
177Absent radius (HP:0003974)1.67919716
178Tubulointerstitial abnormality (HP:0001969)1.67343905
179Rickets (HP:0002748)1.66808524
180Morphological abnormality of the inner ear (HP:0011390)1.66769345
181Abnormality of the duodenum (HP:0002246)1.65911652
182Abnormality of endocrine pancreas physiology (HP:0012093)1.65204584
183Abnormality of the pancreatic islet cells (HP:0006476)1.65204584
184Carpal synostosis (HP:0009702)1.65145010
185Broad ribs (HP:0000885)1.64984031
186Nephroblastoma (Wilms tumor) (HP:0002667)1.64500164
187Enlarged kidneys (HP:0000105)1.64436025
188Elevated hepatic transaminases (HP:0002910)1.64368113
189Short thumb (HP:0009778)1.64184660
190Abnormal enzyme/coenzyme activity (HP:0012379)1.63816251
191Poikilocytosis (HP:0004447)1.63762292
192Facial shape deformation (HP:0011334)1.63542293
193Potter facies (HP:0002009)1.63542293
194Hypoplastic labia majora (HP:0000059)1.63222634
195Sensorimotor neuropathy (HP:0007141)1.62505650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.25220482
2STK38L6.23154926
3ERN14.33222530
4BCKDK4.28981718
5PNCK3.81867859
6NEK13.13700917
7FGFR43.09780067
8SIK13.05233161
9ZAK2.70840097
10NEK22.64526724
11PRKD32.54394185
12EPHB22.45064700
13INSRR2.44287796
14MAPK152.42182802
15STK382.28633452
16MAP2K22.16440180
17TESK22.13609362
18NLK2.10292041
19ERBB42.09278530
20ERBB21.96066096
21TAOK31.93113643
22CDK191.87834367
23UHMK11.84884242
24MAPK111.72412480
25ACVR1B1.68227161
26WEE11.67764964
27MAP3K101.52988882
28PIK3CG1.49130476
29FGFR21.47025716
30TAF11.43284356
31PKN21.42001244
32LATS11.38494940
33KSR11.35946728
34PTK2B1.34273419
35DYRK1B1.33706911
36MAP3K61.30985215
37OXSR11.29583451
38TRIB31.29498124
39STK101.27711391
40CAMK1G1.27443264
41MAP3K111.24554989
42MAP3K21.24273595
43BMPR1B1.23066735
44TYK21.21398638
45AURKA1.20345371
46MST1R1.16782092
47MAP2K41.15592074
48MAP3K81.15236936
49EPHA21.14455128
50FLT31.13239439
51PDPK11.12507083
52CDK121.11613006
53PLK11.09501215
54TTK1.07385510
55DYRK21.04083194
56FGR1.02277839
57IRAK31.01676496
58FRK1.00026541
59PRKCI0.99741188
60KSR20.98570855
61PAK40.98213351
62PTK60.95144540
63MAP4K10.92854610
64AURKB0.91413516
65CDK70.90662315
66PLK20.90415575
67PLK40.90032774
68CDK40.87376608
69ICK0.83463399
70ATR0.80779986
71NEK90.80662305
72CDK60.80323278
73MTOR0.79564788
74EIF2AK30.78891526
75GSK3A0.74457364
76EPHB10.72140384
77LATS20.71799739
78MELK0.71764655
79STK390.70068491
80STK110.68835644
81JAK20.68514932
82GRK60.65742293
83ABL20.65322157
84PTK20.64615838
85STK30.62057210
86DAPK20.61890492
87PBK0.59470914
88PDK20.58975628
89CSK0.58606406
90CSNK1G10.57141776
91CHEK20.56797706
92RET0.56326865
93CSF1R0.55996111
94PRKCZ0.52315680
95STK160.52004052
96PRKAA10.49252282
97NME10.49104994
98RPS6KB20.48943089
99MOS0.48669381
100MET0.48388563
101TBK10.48172640
102PRKD10.46808192
103CDC70.46496315
104BMX0.46463382
105AKT20.43846308
106KDR0.42083771
107CSNK1A1L0.41953356
108PRKACG0.41802495
109CSNK1G30.41210744
110STK40.40733805
111CAMK2G0.39705636
112MARK30.39138165
113CDK30.38854614
114MAP3K90.38479460
115BRD40.37479755
116ADRBK10.37231996
117PINK10.37182189
118FGFR30.35986967
119PIM10.35596218
120MAPK40.35413088
121NEK60.34866750
122WNK40.34809275
123ARAF0.33990239
124TNK20.33793012
125JAK10.32643781
126MAP3K70.32420981
127EIF2AK10.32411773
128EIF2AK20.32236005
129CHEK10.31960986
130BTK0.31718301
131PDGFRB0.31586376
132MAP2K10.30331523
133PAK10.29965011
134BRSK10.29531351
135YES10.28572434
136GRK70.28286581
137CDK10.27261506
138TGFBR10.26154078
139TLK10.25266942
140PIM20.23750758
141ATM0.23512730
142DYRK30.23405252
143CDK20.22644952
144RPS6KA10.22010060
145EPHA30.21975149
146CSNK1E0.21954552
147PRKAA20.21572900
148CSNK1G20.21370241
149TSSK60.21049571
150TYRO30.20883182
151MAP3K140.20527849
152PASK0.19986121
153TAOK20.19973490
154RPS6KB10.19343160
155SIK20.18201436
156CASK0.18090357
157PDK10.16369478
158ITK0.16075263
159PLK30.14529468
160BRAF0.13606126
161RAF10.13546160
162MAPK30.13091396
163MAPK10.09611757
164CSNK2A10.07724477
165CSNK1D0.07096203

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.83292992
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.69713955
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36803213
4Nitrogen metabolism_Homo sapiens_hsa009103.35600610
5Arginine biosynthesis_Homo sapiens_hsa002203.29410456
6Sphingolipid metabolism_Homo sapiens_hsa006003.25990734
7N-Glycan biosynthesis_Homo sapiens_hsa005103.01058875
8Phototransduction_Homo sapiens_hsa047442.99826118
9Dorso-ventral axis formation_Homo sapiens_hsa043202.88953913
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.86663252
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69987132
12Tryptophan metabolism_Homo sapiens_hsa003802.65529381
13Complement and coagulation cascades_Homo sapiens_hsa046102.55986411
14Fanconi anemia pathway_Homo sapiens_hsa034602.49457066
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.43134972
16Fatty acid degradation_Homo sapiens_hsa000712.38303850
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31661550
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13118547
19Peroxisome_Homo sapiens_hsa041462.06278062
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03991002
21Taste transduction_Homo sapiens_hsa047422.03109039
22Butanoate metabolism_Homo sapiens_hsa006502.02814843
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.97494216
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.86288069
25Basal transcription factors_Homo sapiens_hsa030221.85189855
26Chemical carcinogenesis_Homo sapiens_hsa052041.83437249
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.79739402
28PPAR signaling pathway_Homo sapiens_hsa033201.75141432
29Histidine metabolism_Homo sapiens_hsa003401.72155936
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.72093872
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.71870965
32Selenocompound metabolism_Homo sapiens_hsa004501.71343891
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69954795
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68088033
35Non-homologous end-joining_Homo sapiens_hsa034501.64415864
36Fatty acid metabolism_Homo sapiens_hsa012121.62637509
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.61701192
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.60425305
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57206355
40Propanoate metabolism_Homo sapiens_hsa006401.55569080
41Phenylalanine metabolism_Homo sapiens_hsa003601.54859766
42Oocyte meiosis_Homo sapiens_hsa041141.54600832
43Retinol metabolism_Homo sapiens_hsa008301.53130340
44Biosynthesis of amino acids_Homo sapiens_hsa012301.50364013
45Folate biosynthesis_Homo sapiens_hsa007901.48881345
46beta-Alanine metabolism_Homo sapiens_hsa004101.48042663
47Nicotine addiction_Homo sapiens_hsa050331.46658045
48Staphylococcus aureus infection_Homo sapiens_hsa051501.46323398
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44574572
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43415224
51Bile secretion_Homo sapiens_hsa049761.42480478
52Caffeine metabolism_Homo sapiens_hsa002321.41695697
53Tyrosine metabolism_Homo sapiens_hsa003501.40798106
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39607862
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.34307484
56One carbon pool by folate_Homo sapiens_hsa006701.33467002
57Nucleotide excision repair_Homo sapiens_hsa034201.25950647
58Pyruvate metabolism_Homo sapiens_hsa006201.25599597
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.20555328
60Sulfur relay system_Homo sapiens_hsa041221.20403534
61Carbon metabolism_Homo sapiens_hsa012001.14844027
62Steroid biosynthesis_Homo sapiens_hsa001001.14283683
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12148350
64Starch and sucrose metabolism_Homo sapiens_hsa005001.09299482
65Sulfur metabolism_Homo sapiens_hsa009201.08473672
66Fatty acid elongation_Homo sapiens_hsa000621.08176547
67Fat digestion and absorption_Homo sapiens_hsa049751.04881727
68Arginine and proline metabolism_Homo sapiens_hsa003301.04124804
69Lysine degradation_Homo sapiens_hsa003101.03323532
70ABC transporters_Homo sapiens_hsa020101.02209098
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01729526
72mRNA surveillance pathway_Homo sapiens_hsa030150.98453094
73VEGF signaling pathway_Homo sapiens_hsa043700.94807698
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93641630
75Vitamin B6 metabolism_Homo sapiens_hsa007500.90598006
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85068491
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85039580
78RNA degradation_Homo sapiens_hsa030180.81514512
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81225147
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76588877
81Calcium signaling pathway_Homo sapiens_hsa040200.76400872
82Glutathione metabolism_Homo sapiens_hsa004800.74807279
83Vitamin digestion and absorption_Homo sapiens_hsa049770.72269943
84RNA polymerase_Homo sapiens_hsa030200.71872852
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68654885
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67125586
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65527405
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65298190
89Morphine addiction_Homo sapiens_hsa050320.64478669
90Pentose phosphate pathway_Homo sapiens_hsa000300.64259297
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.64192283
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58146151
93Colorectal cancer_Homo sapiens_hsa052100.57746064
94Hippo signaling pathway_Homo sapiens_hsa043900.57449550
95Adherens junction_Homo sapiens_hsa045200.56837103
96Thyroid cancer_Homo sapiens_hsa052160.56835163
97TGF-beta signaling pathway_Homo sapiens_hsa043500.52498099
98Prion diseases_Homo sapiens_hsa050200.48582714
99Glycerolipid metabolism_Homo sapiens_hsa005610.47435129
100Ovarian steroidogenesis_Homo sapiens_hsa049130.45376277
101Metabolic pathways_Homo sapiens_hsa011000.42213251
102Viral myocarditis_Homo sapiens_hsa054160.41682725
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39265963
104Purine metabolism_Homo sapiens_hsa002300.38369466
105Proteasome_Homo sapiens_hsa030500.37997696
106Systemic lupus erythematosus_Homo sapiens_hsa053220.37820409
107Regulation of autophagy_Homo sapiens_hsa041400.36771620
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36558570
109Fatty acid biosynthesis_Homo sapiens_hsa000610.36176932
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34617233
111HTLV-I infection_Homo sapiens_hsa051660.33613835
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33014342
113Small cell lung cancer_Homo sapiens_hsa052220.32536638
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31454025
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29455807
116Fructose and mannose metabolism_Homo sapiens_hsa000510.24810221
117Galactose metabolism_Homo sapiens_hsa000520.24272767
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22846319
119Chronic myeloid leukemia_Homo sapiens_hsa052200.20255150
120Insulin resistance_Homo sapiens_hsa049310.19926809
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.17456553
122Basal cell carcinoma_Homo sapiens_hsa052170.16896366
123GABAergic synapse_Homo sapiens_hsa047270.16454091
124Pancreatic cancer_Homo sapiens_hsa052120.14767837
125Notch signaling pathway_Homo sapiens_hsa043300.14592664
126Spliceosome_Homo sapiens_hsa030400.14154685
127Prostate cancer_Homo sapiens_hsa052150.14103706
128Pyrimidine metabolism_Homo sapiens_hsa002400.11909877
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10150834
130Glucagon signaling pathway_Homo sapiens_hsa049220.09683284
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.09608485
132Endometrial cancer_Homo sapiens_hsa052130.09410897
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08539428
134Linoleic acid metabolism_Homo sapiens_hsa005910.05765179
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.05176403
136Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.02152207
137AMPK signaling pathway_Homo sapiens_hsa041520.02041309
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.01169899
139Bladder cancer_Homo sapiens_hsa052190.00787976
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00155074
141Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1965599
142Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1886955
143Homologous recombination_Homo sapiens_hsa03440-0.1851030
144DNA replication_Homo sapiens_hsa03030-0.1625109
145RNA transport_Homo sapiens_hsa03013-0.1449832
146Insulin signaling pathway_Homo sapiens_hsa04910-0.1327914
147Base excision repair_Homo sapiens_hsa03410-0.1227731
148Mismatch repair_Homo sapiens_hsa03430-0.1136149
149Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1003691
150Cell cycle_Homo sapiens_hsa04110-0.0970926
151Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0773744
152p53 signaling pathway_Homo sapiens_hsa04115-0.0506821
153Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0031242

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