ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	7.92965196
2	acrosome reaction (GO:0007340)	7.49271623
3	microtubule depolymerization (GO:0007019)	7.18396238
4	fusion of sperm to egg plasma membrane (GO:0007342)	6.98720695
5	centriole replication (GO:0007099)	6.68395403
6	protein polyglutamylation (GO:0018095)	6.09560786
7	microtubule polymerization or depolymerization (GO:0031109)	6.02718441
8	protein targeting to Golgi (GO:0000042)	5.74317485
9	establishment of protein localization to Golgi (GO:0072600)	5.65991295
10	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.52801267
11	rRNA methylation (GO:0031167)	5.44929572
12	spermatid development (GO:0007286)	5.44367465
13	multicellular organism reproduction (GO:0032504)	5.39255287
14	centriole assembly (GO:0098534)	5.26290013
15	regulation of centriole replication (GO:0046599)	5.23270745
16	plasma membrane fusion (GO:0045026)	5.17731097
17	protein neddylation (GO:0045116)	5.17508304
18	chromosome condensation (GO:0030261)	5.08206830
19	sperm-egg recognition (GO:0035036)	5.04794280
20	DNA packaging (GO:0006323)	5.02701392
21	rRNA modification (GO:0000154)	4.96717154
22	response to pheromone (GO:0019236)	4.95509774
23	regulation of cilium movement (GO:0003352)	4.89742506
24	male meiosis (GO:0007140)	4.68697050
25	spermatid nucleus differentiation (GO:0007289)	4.50757898
26	seminiferous tubule development (GO:0072520)	4.46027548
27	epithelial cilium movement (GO:0003351)	4.44187811
28	protein localization to Golgi apparatus (GO:0034067)	4.43429354
29	piRNA metabolic process (GO:0034587)	4.41303972
30	spermatogenesis (GO:0007283)	4.39658045
31	male gamete generation (GO:0048232)	4.38781357
32	single strand break repair (GO:0000012)	4.16317037
33	binding of sperm to zona pellucida (GO:0007339)	4.12297547
34	gamete generation (GO:0007276)	4.08931532
35	cell-cell recognition (GO:0009988)	4.07556145
36	synapsis (GO:0007129)	4.06947304
37	sperm capacitation (GO:0048240)	4.04028154
38	reproduction (GO:0000003)	4.03383712
39	cilium or flagellum-dependent cell motility (GO:0001539)	4.02569711
40	axonemal dynein complex assembly (GO:0070286)	3.97012288
41	histone exchange (GO:0043486)	3.95227806
42	regulation of meiosis I (GO:0060631)	3.92771888
43	calcium ion-dependent exocytosis (GO:0017156)	3.89675668
44	male meiosis I (GO:0007141)	3.89564826
45	DNA methylation involved in gamete generation (GO:0043046)	3.82238805
46	meiosis I (GO:0007127)	3.74169602
47	single fertilization (GO:0007338)	3.70384625
48	cilium movement (GO:0003341)	3.65613769
49	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.63654112
50	resolution of meiotic recombination intermediates (GO:0000712)	3.37509375
51	chromosome organization involved in meiosis (GO:0070192)	3.36319211
52	fertilization (GO:0009566)	3.35426608
53	microtubule nucleation (GO:0007020)	3.31478542
54	motile cilium assembly (GO:0044458)	3.29279241
55	cellular biogenic amine biosynthetic process (GO:0042401)	3.29064658
56	thrombin receptor signaling pathway (GO:0070493)	3.23247142
57	germ cell development (GO:0007281)	3.21551647
58	meiotic nuclear division (GO:0007126)	3.19640096
59	multicellular organismal reproductive process (GO:0048609)	3.17743655
60	behavioral response to nicotine (GO:0035095)	3.17489439
61	axoneme assembly (GO:0035082)	3.17401014
62	double-strand break repair via homologous recombination (GO:0000724)	3.16243594
63	microtubule severing (GO:0051013)	3.14740682
64	recombinational repair (GO:0000725)	3.14639828
65	amine biosynthetic process (GO:0009309)	3.14232148
66	chromatin remodeling at centromere (GO:0031055)	3.11522514
67	meiotic chromosome segregation (GO:0045132)	3.11499293
68	DNA double-strand break processing (GO:0000729)	3.07565103
69	indolalkylamine metabolic process (GO:0006586)	3.05749630
70	CENP-A containing nucleosome assembly (GO:0034080)	3.03562510
71	regulation of microtubule-based movement (GO:0060632)	2.95876713
72	regulation of centrosome duplication (GO:0010824)	2.95759532
73	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.93533489
74	polyamine biosynthetic process (GO:0006596)	2.91774320
75	reciprocal DNA recombination (GO:0035825)	2.90684549
76	reciprocal meiotic recombination (GO:0007131)	2.90684549
77	negative regulation of heart rate (GO:0010459)	2.88217057
78	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.85653387
79	centrosome organization (GO:0051297)	2.85250655
80	meiotic cell cycle process (GO:1903046)	2.85038203
81	negative regulation of response to food (GO:0032096)	2.82202059
82	negative regulation of appetite (GO:0032099)	2.82202059
83	centrosome duplication (GO:0051298)	2.80127423
84	ventricular system development (GO:0021591)	2.78672467
85	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.73136433
86	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.69084030
87	phosphatidylethanolamine metabolic process (GO:0046337)	2.68247744
88	cilium organization (GO:0044782)	2.66596519
89	regulation of centrosome cycle (GO:0046605)	2.64554914
90	microtubule organizing center organization (GO:0031023)	2.63640721
91	cilium assembly (GO:0042384)	2.61645951
92	glycerol ether metabolic process (GO:0006662)	2.59876899
93	somite development (GO:0061053)	2.53433222
94	positive regulation of Rab GTPase activity (GO:0032851)	2.50710352
95	regulation of Rab GTPase activity (GO:0032313)	2.50710352
96	replication fork processing (GO:0031297)	2.45720944
97	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.45683805
98	NADH dehydrogenase complex assembly (GO:0010257)	2.45683805
99	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.45683805
100	synaptonemal complex assembly (GO:0007130)	2.43602720

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.33822452
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.22685282
3	VDR_22108803_ChIP-Seq_LS180_Human	2.93323479
4	FUS_26573619_Chip-Seq_HEK293_Human	2.92224822
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.85224115
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.60651744
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.43723928
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.36175038
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35360319
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.34494990
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.25145618
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.23536580
13	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.23536580
14	P300_19829295_ChIP-Seq_ESCs_Human	2.15983701
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.15723382
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.15207818
17	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	2.14452309
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.08049784
19	ER_23166858_ChIP-Seq_MCF-7_Human	2.02604541
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.01122887
21	EWS_26573619_Chip-Seq_HEK293_Human	1.90850151
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.85354345
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.85005772
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.85005772
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.77567918
26	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.67409091
27	AR_25329375_ChIP-Seq_VCAP_Human	1.63367118
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.61460781
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57927156
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56581597
31	SOX2_19829295_ChIP-Seq_ESCs_Human	1.50249801
32	NANOG_19829295_ChIP-Seq_ESCs_Human	1.50249801
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47088333
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.45685227
35	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.45479538
36	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.45318607
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45241831
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.44743986
39	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.44257146
40	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.43103568
41	STAT3_23295773_ChIP-Seq_U87_Human	1.42073601
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.34213193
43	RBPJ_21746931_ChIP-Seq_IB4_Human	1.30247539
44	NFYB_21822215_ChIP-Seq_K562_Human	1.30082003
45	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.28637231
46	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27590484
47	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27421292
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26827197
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26190858
50	ETV1_20927104_ChIP-Seq_GIST48_Human	1.26129117
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.25423575
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25199611
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.23838801
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23202479
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23202479
56	PHF8_20622853_ChIP-Seq_HELA_Human	1.22671931
57	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.22393952
58	MYC_19829295_ChIP-Seq_ESCs_Human	1.22004197
59	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.21792344
60	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.21755138
61	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.21536434
62	TBL1_22424771_ChIP-Seq_293T_Human	1.21147773
63	ERG_20517297_ChIP-Seq_VCAP_Human	1.20630256
64	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.20463377
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19631328
66	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.19489079
67	NANOG_20526341_ChIP-Seq_ESCs_Human	1.18890369
68	BCAT_22108803_ChIP-Seq_LS180_Human	1.18702588
69	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.17794394
70	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17633797
71	TCF4_23295773_ChIP-Seq_U87_Human	1.16771207
72	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.16299053
73	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14457552
74	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.13081013
75	MYC_18940864_ChIP-ChIP_HL60_Human	1.12351505
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12251482
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11887799
78	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.11295259
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10980191
80	NFYA_21822215_ChIP-Seq_K562_Human	1.10173486
81	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.09699388
82	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.09155842
83	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.08517369
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08422390
85	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08311204
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08304462
87	ERA_21632823_ChIP-Seq_H3396_Human	1.06673417
88	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06214982
89	NCOR_22424771_ChIP-Seq_293T_Human	1.06145586
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05949064
91	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.05548181
92	TAF2_19829295_ChIP-Seq_ESCs_Human	1.04999792
93	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04347045
94	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03629535
95	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02912813
96	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.01471283
97	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.01175349
98	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.01147971
99	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00371107
100	TP53_22573176_ChIP-Seq_HFKS_Human	1.00093143

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.45650059
2	MP0003878_abnormal_ear_physiology	3.26355839
3	MP0005377_hearing/vestibular/ear_phenot	3.26355839
4	MP0003698_abnormal_male_reproductive	2.96953711
5	MP0001929_abnormal_gametogenesis	2.79413313
6	MP0005171_absent_coat_pigmentation	2.75912714
7	MP0003136_yellow_coat_color	2.64999637
8	MP0005670_abnormal_white_adipose	2.63042888
9	MP0006292_abnormal_olfactory_placode	2.60520681
10	MP0008877_abnormal_DNA_methylation	2.49838686
11	MP0003718_maternal_effect	2.34649714
12	MP0002102_abnormal_ear_morphology	2.20021881
13	MP0001485_abnormal_pinna_reflex	2.10394528
14	MP0003646_muscle_fatigue	2.01435607
15	MP0002210_abnormal_sex_determination	1.96948428
16	MP0009697_abnormal_copulation	1.91620839
17	MP0005551_abnormal_eye_electrophysiolog	1.79210346
18	MP0000372_irregular_coat_pigmentation	1.78177854
19	MP0005464_abnormal_platelet_physiology	1.72175612
20	MP0010094_abnormal_chromosome_stability	1.71559970
21	MP0008872_abnormal_physiological_respon	1.67405114
22	MP0002234_abnormal_pharynx_morphology	1.67393937
23	MP0008004_abnormal_stomach_pH	1.65805614
24	MP0005253_abnormal_eye_physiology	1.64987098
25	MP0001486_abnormal_startle_reflex	1.62891023
26	MP0001145_abnormal_male_reproductive	1.56722834
27	MP0005167_abnormal_blood-brain_barrier	1.52938816
28	MP0000653_abnormal_sex_gland	1.52874104
29	MP0008058_abnormal_DNA_repair	1.52442995
30	MP0002095_abnormal_skin_pigmentation	1.51969172
31	MP0002161_abnormal_fertility/fecundity	1.51929064
32	MP0005646_abnormal_pituitary_gland	1.47318771
33	MP0002653_abnormal_ependyma_morphology	1.39704964
34	MP0002938_white_spotting	1.39640146
35	MP0006276_abnormal_autonomic_nervous	1.39359903
36	MP0000015_abnormal_ear_pigmentation	1.36173806
37	MP0001293_anophthalmia	1.31246520
38	MP0002736_abnormal_nociception_after	1.31136948
39	MP0003195_calcinosis	1.30177397
40	MP0005083_abnormal_biliary_tract	1.28985640
41	MP0001529_abnormal_vocalization	1.27437483
42	MP0005084_abnormal_gallbladder_morpholo	1.25403365
43	MP0000230_abnormal_systemic_arterial	1.23928938
44	MP0008789_abnormal_olfactory_epithelium	1.23573555
45	MP0001968_abnormal_touch/_nociception	1.23003087
46	MP0003077_abnormal_cell_cycle	1.22384915
47	MP0000026_abnormal_inner_ear	1.21269101
48	MP0001984_abnormal_olfaction	1.20338332
49	MP0005379_endocrine/exocrine_gland_phen	1.19164921
50	MP0009053_abnormal_anal_canal	1.19078051
51	MP0004742_abnormal_vestibular_system	1.16764251
52	MP0005174_abnormal_tail_pigmentation	1.16023063
53	MP0002282_abnormal_trachea_morphology	1.14744736
54	MP0005499_abnormal_olfactory_system	1.10507547
55	MP0005394_taste/olfaction_phenotype	1.10507547
56	MP0001963_abnormal_hearing_physiology	1.10340848
57	MP0001905_abnormal_dopamine_level	1.07997517
58	MP0000631_abnormal_neuroendocrine_gland	1.07869632
59	MP0003011_delayed_dark_adaptation	1.07121955
60	MP0000049_abnormal_middle_ear	1.02924165
61	MP0004084_abnormal_cardiac_muscle	1.01256702
62	MP0003693_abnormal_embryo_hatching	0.99031945
63	MP0004142_abnormal_muscle_tone	0.97746872
64	MP0002160_abnormal_reproductive_system	0.95104511
65	MP0000569_abnormal_digit_pigmentation	0.94956622
66	MP0003880_abnormal_central_pattern	0.94279610
67	MP0005075_abnormal_melanosome_morpholog	0.93312505
68	MP0005645_abnormal_hypothalamus_physiol	0.88721160
69	MP0003119_abnormal_digestive_system	0.87965064
70	MP0001324_abnormal_eye_pigmentation	0.85792406
71	MP0009745_abnormal_behavioral_response	0.85765037
72	MP0002735_abnormal_chemical_nociception	0.84582168
73	MP0006072_abnormal_retinal_apoptosis	0.84171047
74	MP0005391_vision/eye_phenotype	0.83350659
75	MP0002163_abnormal_gland_morphology	0.83078813
76	MP0001879_abnormal_lymphatic_vessel	0.82870110
77	MP0002638_abnormal_pupillary_reflex	0.81955293
78	MP0000566_synostosis	0.81904596
79	MP0004957_abnormal_blastocyst_morpholog	0.81903469
80	MP0004215_abnormal_myocardial_fiber	0.81517941
81	MP0002132_abnormal_respiratory_system	0.80338013
82	MP0005310_abnormal_salivary_gland	0.78081167
83	MP0002557_abnormal_social/conspecific_i	0.77327793
84	MP0002272_abnormal_nervous_system	0.75389712
85	MP0002067_abnormal_sensory_capabilities	0.73623008
86	MP0003111_abnormal_nucleus_morphology	0.73235962
87	MP0005187_abnormal_penis_morphology	0.72366756
88	MP0005389_reproductive_system_phenotype	0.72164272
89	MP0002233_abnormal_nose_morphology	0.71946381
90	MP0003638_abnormal_response/metabolism_	0.70911316
91	MP0001119_abnormal_female_reproductive	0.70899502
92	MP0005408_hypopigmentation	0.69697568
93	MP0008995_early_reproductive_senescence	0.66697337
94	MP0005195_abnormal_posterior_eye	0.65817224
95	MP0004484_altered_response_of	0.65553921
96	MP0001286_abnormal_eye_development	0.64169940
97	MP0002572_abnormal_emotion/affect_behav	0.61915623
98	MP0004085_abnormal_heartbeat	0.61826941
99	MP0008057_abnormal_DNA_replication	0.61522610
100	MP0008932_abnormal_embryonic_tissue	0.61403348

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.51372834
2	Absent/shortened dynein arms (HP:0200106)	4.51372834
3	Chronic hepatic failure (HP:0100626)	4.10184446
4	Abnormal ciliary motility (HP:0012262)	3.61796127
5	Tubulointerstitial nephritis (HP:0001970)	3.60986178
6	Abnormal respiratory epithelium morphology (HP:0012253)	3.27538339
7	Abnormal respiratory motile cilium morphology (HP:0005938)	3.27538339
8	Severe visual impairment (HP:0001141)	3.24961828
9	Nephronophthisis (HP:0000090)	3.19508294
10	Attenuation of retinal blood vessels (HP:0007843)	3.18991213
11	Pancreatic cysts (HP:0001737)	3.16204673
12	Type II lissencephaly (HP:0007260)	3.12296915
13	Abnormal respiratory motile cilium physiology (HP:0012261)	3.05757524
14	3-Methylglutaconic aciduria (HP:0003535)	3.02856040
15	Decreased central vision (HP:0007663)	3.02781253
16	Pancreatic fibrosis (HP:0100732)	3.02184712
17	Bony spicule pigmentary retinopathy (HP:0007737)	2.95903468
18	Abnormality of midbrain morphology (HP:0002418)	2.80450577
19	Molar tooth sign on MRI (HP:0002419)	2.80450577
20	True hermaphroditism (HP:0010459)	2.80146289
21	Abnormality of the renal medulla (HP:0100957)	2.75920676
22	Pendular nystagmus (HP:0012043)	2.73524543
23	Abnormality of macular pigmentation (HP:0008002)	2.69803734
24	Optic nerve hypoplasia (HP:0000609)	2.65833941
25	Renal Fanconi syndrome (HP:0001994)	2.64137881
26	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.63128023
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.61055363
28	Prolonged bleeding time (HP:0003010)	2.57863512
29	Abnormality of the ileum (HP:0001549)	2.56837972
30	Meckel diverticulum (HP:0002245)	2.52165718
31	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.49453801
32	Polydipsia (HP:0001959)	2.46778237
33	Abnormal drinking behavior (HP:0030082)	2.46778237
34	Duodenal stenosis (HP:0100867)	2.42998226
35	Small intestinal stenosis (HP:0012848)	2.42998226
36	Impulsivity (HP:0100710)	2.35736708
37	Polyuria (HP:0000103)	2.35204092
38	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.30530210
39	Abnormality of lateral ventricle (HP:0030047)	2.29373280
40	Congenital stationary night blindness (HP:0007642)	2.28812191
41	Ectopic kidney (HP:0000086)	2.26955272
42	Generalized aminoaciduria (HP:0002909)	2.26199227
43	Abolished electroretinogram (ERG) (HP:0000550)	2.25886791
44	Congenital, generalized hypertrichosis (HP:0004540)	2.25448927
45	Retinal dysplasia (HP:0007973)	2.20844184
46	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.19837534
47	Congenital sensorineural hearing impairment (HP:0008527)	2.18636010
48	Anencephaly (HP:0002323)	2.17183131
49	Cerebellar dysplasia (HP:0007033)	2.16995018
50	Abnormality of the renal cortex (HP:0011035)	2.16127567
51	Cystic liver disease (HP:0006706)	2.14351349
52	Abnormal urine output (HP:0012590)	2.11586160
53	Tubular atrophy (HP:0000092)	2.11063839
54	Cone-rod dystrophy (HP:0000548)	2.07909892
55	Abnormality of the duodenum (HP:0002246)	2.05521117
56	Male pseudohermaphroditism (HP:0000037)	2.04069811
57	Sloping forehead (HP:0000340)	2.02504388
58	Abnormality of chromosome stability (HP:0003220)	2.00499017
59	Tubulointerstitial abnormality (HP:0001969)	2.00048407
60	Anophthalmia (HP:0000528)	1.99628303
61	Medial flaring of the eyebrow (HP:0010747)	1.99475695
62	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.99201474
63	Abnormality of renal resorption (HP:0011038)	1.95395305
64	Triphalangeal thumb (HP:0001199)	1.95017933
65	Abnormality of cochlea (HP:0000375)	1.94914670
66	Sclerocornea (HP:0000647)	1.94319885
67	Gastrointestinal atresia (HP:0002589)	1.94058922
68	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.92993049
69	Hypoplasia of the fovea (HP:0007750)	1.92993049
70	Intellectual disability, moderate (HP:0002342)	1.92726963
71	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.91626715
72	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.90639884
73	Absent thumb (HP:0009777)	1.90609530
74	Birth length less than 3rd percentile (HP:0003561)	1.89444341
75	Postaxial foot polydactyly (HP:0001830)	1.89011248
76	Male infertility (HP:0003251)	1.88157558
77	Occipital encephalocele (HP:0002085)	1.87595872
78	Glycosuria (HP:0003076)	1.87565096
79	Abnormality of urine glucose concentration (HP:0011016)	1.87565096
80	Growth hormone deficiency (HP:0000824)	1.87516273
81	Abnormal spermatogenesis (HP:0008669)	1.86191075
82	Lissencephaly (HP:0001339)	1.85391842
83	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84943503
84	Abnormality of alanine metabolism (HP:0010916)	1.84943503
85	Hyperalaninemia (HP:0003348)	1.84943503
86	Astigmatism (HP:0000483)	1.84361560
87	Stage 5 chronic kidney disease (HP:0003774)	1.84127654
88	Dyschromatopsia (HP:0007641)	1.83464265
89	Infertility (HP:0000789)	1.82717812
90	Menorrhagia (HP:0000132)	1.82710187
91	Clubbing of toes (HP:0100760)	1.82055935
92	Abnormality of the preputium (HP:0100587)	1.80942363
93	Morphological abnormality of the inner ear (HP:0011390)	1.80911740
94	Increased mean platelet volume (HP:0011877)	1.78490506
95	Petechiae (HP:0000967)	1.78401662
96	Abnormality of renal excretion (HP:0011036)	1.78225364
97	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.78150603
98	Portal hypertension (HP:0001409)	1.75115142
99	Esophageal atresia (HP:0002032)	1.73862392
100	Amelogenesis imperfecta (HP:0000705)	1.72700451

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	6.23790493
2	INSRR	4.52031950
3	PNCK	3.72398490
4	PLK2	2.80295594
5	MAP4K2	2.56787444
6	ZAK	2.40797823
7	BMPR1B	2.36727022
8	BRD4	2.08342147
9	FRK	2.00375359
10	TAF1	1.99203063
11	WEE1	1.95513982
12	WNK3	1.95409330
13	CAMK1G	1.93743507
14	NUAK1	1.88791350
15	CDC7	1.73742948
16	PIK3CG	1.61680621
17	ADRBK2	1.50295595
18	TNIK	1.49626839
19	STK38L	1.48755675
20	ACVR1B	1.47283438
21	BRSK2	1.44703570
22	PTK2B	1.44673250
23	MAP3K4	1.39230915
24	TIE1	1.32574179
25	MST4	1.24831924
26	MKNK1	1.23209942
27	TRIM28	1.20646121
28	TLK1	1.19757586
29	GRK1	1.19204832
30	VRK1	1.18653926
31	CCNB1	1.16515308
32	TAOK3	1.15487631
33	NEK2	1.12902242
34	STK39	1.12338853
35	MKNK2	1.08670458
36	TEC	1.07737507
37	EIF2AK1	1.04703932
38	MAPK15	1.02532574
39	MAP2K7	1.01994702
40	DDR2	1.00496990
41	PLK3	0.95779610
42	STK3	0.93081214
43	VRK2	0.92526431
44	DYRK2	0.92427245
45	CAMK1D	0.87582353
46	DYRK3	0.87079323
47	PINK1	0.86268349
48	PLK1	0.83505478
49	TYRO3	0.82798236
50	OXSR1	0.80242333
51	CDK3	0.77926368
52	MAPK13	0.74648776
53	BRSK1	0.70668057
54	MYLK	0.69113075
55	PKN1	0.68149216
56	BMPR2	0.67324292
57	WNK4	0.65032683
58	MARK3	0.64581458
59	PRKCG	0.62130916
60	BMX	0.61823093
61	TGFBR1	0.61121626
62	PRKG1	0.58665472
63	CAMK1	0.57643961
64	CHEK2	0.57375250
65	MAPKAPK5	0.57104928
66	NEK1	0.55373795
67	CDK7	0.55103093
68	GRK5	0.53823545
69	TXK	0.53545609
70	ATR	0.52937467
71	DYRK1B	0.52761313
72	BUB1	0.52576856
73	RPS6KA5	0.50244294
74	ILK	0.49393474
75	CSNK1G1	0.47382817
76	STK16	0.46385458
77	NME1	0.46242406
78	TTK	0.45917387
79	EIF2AK3	0.45642528
80	CSNK1G3	0.43440709
81	NLK	0.42208655
82	CDK19	0.42204271
83	IKBKB	0.41347068
84	CSF1R	0.40440750
85	EPHB2	0.36652883
86	RPS6KA4	0.36304707
87	ADRBK1	0.35321211
88	PRKCE	0.32977172
89	CSNK1G2	0.31589091
90	AURKB	0.30233847
91	ATM	0.29306933
92	CDK1	0.28182116
93	PAK3	0.27728983
94	MINK1	0.27470238
95	CAMK2A	0.27432403
96	PRKACA	0.27311232
97	CHUK	0.26035262
98	BRAF	0.25996453
99	CDK8	0.23965944
100	ROCK1	0.23302752

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mismatch repair_Homo sapiens_hsa03430	3.33763783
2	Homologous recombination_Homo sapiens_hsa03440	3.30872190
3	Fanconi anemia pathway_Homo sapiens_hsa03460	3.16427814
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.95716107
5	Olfactory transduction_Homo sapiens_hsa04740	2.84324376
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.45130667
7	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.40471928
8	DNA replication_Homo sapiens_hsa03030	2.30729534
9	Phototransduction_Homo sapiens_hsa04744	2.15993998
10	Basal transcription factors_Homo sapiens_hsa03022	2.14441090
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.10003085
12	RNA transport_Homo sapiens_hsa03013	1.88709086
13	Parkinsons disease_Homo sapiens_hsa05012	1.87122349
14	Huntingtons disease_Homo sapiens_hsa05016	1.85442118
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82130896
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.76267620
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.65879915
18	Butanoate metabolism_Homo sapiens_hsa00650	1.62236423
19	Ribosome_Homo sapiens_hsa03010	1.61200795
20	RNA polymerase_Homo sapiens_hsa03020	1.55938677
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.48498072
22	Base excision repair_Homo sapiens_hsa03410	1.39719511
23	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.38347505
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.38285478
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.36541688
26	Propanoate metabolism_Homo sapiens_hsa00640	1.36478157
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.33381841
28	Purine metabolism_Homo sapiens_hsa00230	1.30821824
29	Protein export_Homo sapiens_hsa03060	1.29203779
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.28559030
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26530029
32	RNA degradation_Homo sapiens_hsa03018	1.24853214
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.23276252
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.23013363
35	Taste transduction_Homo sapiens_hsa04742	1.21706541
36	Glycerolipid metabolism_Homo sapiens_hsa00561	1.20405661
37	Cell cycle_Homo sapiens_hsa04110	1.19622179
38	Proteasome_Homo sapiens_hsa03050	1.14400177
39	Serotonergic synapse_Homo sapiens_hsa04726	1.03178373
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.01297935
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.00675064
42	Fatty acid degradation_Homo sapiens_hsa00071	0.98350641
43	Platelet activation_Homo sapiens_hsa04611	0.97720812
44	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.94284289
45	Alzheimers disease_Homo sapiens_hsa05010	0.93999355
46	Morphine addiction_Homo sapiens_hsa05032	0.91637871
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91605438
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.88022389
49	ABC transporters_Homo sapiens_hsa02010	0.86699538
50	Asthma_Homo sapiens_hsa05310	0.86398340
51	Regulation of autophagy_Homo sapiens_hsa04140	0.85561909
52	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.85550482
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84615828
54	Retinol metabolism_Homo sapiens_hsa00830	0.84384513
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83571604
56	One carbon pool by folate_Homo sapiens_hsa00670	0.82369064
57	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.80935510
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.77529163
59	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.77081177
60	Spliceosome_Homo sapiens_hsa03040	0.77060813
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76677836
62	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.75335452
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.73692444
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72867495
65	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.72474100
66	Oocyte meiosis_Homo sapiens_hsa04114	0.72268637
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71292556
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.70669028
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.69597546
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.67784413
71	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.67228978
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67160599
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62959378
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.62476423
75	Selenocompound metabolism_Homo sapiens_hsa00450	0.62002458
76	Nicotine addiction_Homo sapiens_hsa05033	0.61879585
77	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.61112025
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60784109
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.60601545
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60138587
81	Sulfur relay system_Homo sapiens_hsa04122	0.59027995
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58676290
83	Metabolic pathways_Homo sapiens_hsa01100	0.57179617
84	Circadian entrainment_Homo sapiens_hsa04713	0.53289052
85	Glutathione metabolism_Homo sapiens_hsa00480	0.53022618
86	Alcoholism_Homo sapiens_hsa05034	0.52956628
87	Graft-versus-host disease_Homo sapiens_hsa05332	0.45329081
88	Allograft rejection_Homo sapiens_hsa05330	0.44172938
89	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.43624133
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43612612
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.43126972
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.42887735
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.42360737
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.41440459
95	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.39551619
96	GABAergic synapse_Homo sapiens_hsa04727	0.39263239
97	Pancreatic secretion_Homo sapiens_hsa04972	0.39090610
98	Basal cell carcinoma_Homo sapiens_hsa05217	0.38283247
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.36453299
100	Salivary secretion_Homo sapiens_hsa04970	0.34468793

OVOS2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »