OXA1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.36226285
2viral transcription (GO:0019083)5.24496766
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.06675879
4translational termination (GO:0006415)5.02965182
5behavioral response to nicotine (GO:0035095)4.78151972
6translational elongation (GO:0006414)4.60908271
7formation of translation preinitiation complex (GO:0001731)4.56856820
8membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.52097513
9ribosomal small subunit biogenesis (GO:0042274)4.20968404
10membrane repolarization during action potential (GO:0086011)4.14090085
11nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.08900730
12translational initiation (GO:0006413)4.07404087
13tricarboxylic acid cycle (GO:0006099)4.00748819
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.98869645
15maturation of SSU-rRNA (GO:0030490)3.98733936
16positive regulation of fatty acid beta-oxidation (GO:0032000)3.97572461
17oxidative phosphorylation (GO:0006119)3.95078139
18viral life cycle (GO:0019058)3.88560183
19protein targeting to ER (GO:0045047)3.86806462
20cotranslational protein targeting to membrane (GO:0006613)3.85572551
21cellular protein complex disassembly (GO:0043624)3.81230908
22ribosomal large subunit biogenesis (GO:0042273)3.80502767
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.76903520
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.68572560
25intestinal cholesterol absorption (GO:0030299)3.64788881
26protein localization to endoplasmic reticulum (GO:0070972)3.59417362
27lysine catabolic process (GO:0006554)3.54705342
28lysine metabolic process (GO:0006553)3.54705342
29electron transport chain (GO:0022900)3.53001137
30protein complex disassembly (GO:0043241)3.48809659
31folic acid-containing compound biosynthetic process (GO:0009396)3.46150477
32DNA strand elongation involved in DNA replication (GO:0006271)3.41920947
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38870146
34positive regulation of fatty acid oxidation (GO:0046321)3.37515649
35glycine metabolic process (GO:0006544)3.37272809
36nucleobase biosynthetic process (GO:0046112)3.36695445
37NADH metabolic process (GO:0006734)3.32854551
38macromolecular complex disassembly (GO:0032984)3.32585154
39regulation of skeletal muscle contraction (GO:0014819)3.32114654
40chaperone-mediated protein transport (GO:0072321)3.30732378
412-oxoglutarate metabolic process (GO:0006103)3.28912894
42negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.25532994
43oxaloacetate metabolic process (GO:0006107)3.24764613
44DNA strand elongation (GO:0022616)3.23943386
45telomere maintenance via semi-conservative replication (GO:0032201)3.22869433
46negative regulation of fibrinolysis (GO:0051918)3.21076364
47water-soluble vitamin biosynthetic process (GO:0042364)3.18710937
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16127262
49cellular response to exogenous dsRNA (GO:0071360)3.15474559
50very-low-density lipoprotein particle assembly (GO:0034379)3.13928954
51negative regulation of response to food (GO:0032096)3.10158610
52negative regulation of appetite (GO:0032099)3.10158610
53DNA unwinding involved in DNA replication (GO:0006268)3.09991807
54purine nucleobase biosynthetic process (GO:0009113)3.08083904
55ribonucleoprotein complex biogenesis (GO:0022613)3.06184564
56folic acid metabolic process (GO:0046655)3.03318564
57nuclear-transcribed mRNA catabolic process (GO:0000956)3.00660281
58sarcomere organization (GO:0045214)2.99119237
59translation (GO:0006412)2.98901060
60energy coupled proton transport, down electrochemical gradient (GO:0015985)2.98627199
61ATP synthesis coupled proton transport (GO:0015986)2.98627199
62regulation of sequestering of triglyceride (GO:0010889)2.98475279
63* mitochondrial respiratory chain complex I assembly (GO:0032981)2.96484675
64* NADH dehydrogenase complex assembly (GO:0010257)2.96484675
65* mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96484675
66* establishment of protein localization to membrane (GO:0090150)2.94101925
67negative regulation of potassium ion transmembrane transport (GO:1901380)2.91330025
68DNA deamination (GO:0045006)2.90398507
69DNA replication initiation (GO:0006270)2.88996773
70cell proliferation in forebrain (GO:0021846)2.86684950
71cardiac myofibril assembly (GO:0055003)2.86537982
72regulation of synapse maturation (GO:0090128)2.85519300
73parturition (GO:0007567)2.85497681
74plasma lipoprotein particle assembly (GO:0034377)2.84524247
75protein localization to kinetochore (GO:0034501)2.84362092
76regulation of cholesterol storage (GO:0010885)2.84131819
77mRNA catabolic process (GO:0006402)2.83442157
78tricarboxylic acid metabolic process (GO:0072350)2.82978144
79fatty acid beta-oxidation (GO:0006635)2.81076091
80serine family amino acid biosynthetic process (GO:0009070)2.79718223
81inner mitochondrial membrane organization (GO:0007007)2.79669511
82* protein complex biogenesis (GO:0070271)2.79094379
83cellular anion homeostasis (GO:0030002)2.77797665
84ubiquinone biosynthetic process (GO:0006744)2.76998246
85regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.76878375
86RNA catabolic process (GO:0006401)2.76218129
87valine metabolic process (GO:0006573)2.75625605
88telomere maintenance via recombination (GO:0000722)2.75228476
89mitochondrial fusion (GO:0008053)2.75092140
90negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.74920516
91IMP biosynthetic process (GO:0006188)2.74432561
92short-term memory (GO:0007614)2.72776148
93DNA replication checkpoint (GO:0000076)2.72308650
94diacylglycerol metabolic process (GO:0046339)2.69248090
95establishment of protein localization to organelle (GO:0072594)2.69047059
96protein targeting (GO:0006605)2.68722487
97positive regulation of synapse maturation (GO:0090129)2.67512848
98glyoxylate metabolic process (GO:0046487)2.67376421
99CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.67373286
100tooth mineralization (GO:0034505)2.67171670
101aspartate family amino acid catabolic process (GO:0009068)2.66872467
102telomere maintenance via telomere lengthening (GO:0010833)2.66170866
103regulation of mitochondrial translation (GO:0070129)2.65896578
104mitotic metaphase plate congression (GO:0007080)2.65863106
105vitamin A metabolic process (GO:0006776)2.65287118
106galactose catabolic process (GO:0019388)2.62772957
107pteridine-containing compound biosynthetic process (GO:0042559)2.61636449
108nucleoside transmembrane transport (GO:1901642)2.60404162
109carnitine shuttle (GO:0006853)2.60348790
110ATP biosynthetic process (GO:0006754)2.58760083
111rRNA metabolic process (GO:0016072)2.58053040
112mitotic chromosome condensation (GO:0007076)2.56338770
113* mitochondrial respiratory chain complex assembly (GO:0033108)2.55397868
114sulfation (GO:0051923)2.54981304
115interkinetic nuclear migration (GO:0022027)2.54341558
116protein targeting to membrane (GO:0006612)2.53883783
117ubiquinone metabolic process (GO:0006743)2.53776886
118L-serine metabolic process (GO:0006563)2.53642558
119spliceosomal snRNP assembly (GO:0000387)2.53461542
120mitotic recombination (GO:0006312)2.53268004
121amino-acid betaine metabolic process (GO:0006577)2.52843475
122carnitine metabolic process (GO:0009437)2.52838956
123branched-chain amino acid catabolic process (GO:0009083)2.52829557
124quinone biosynthetic process (GO:1901663)2.52782356
125erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.52133654
126L-phenylalanine catabolic process (GO:0006559)2.52133654
127low-density lipoprotein particle remodeling (GO:0034374)2.51214003
128fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.50146333
129ncRNA 3-end processing (GO:0043628)2.49866395
130spliceosomal tri-snRNP complex assembly (GO:0000244)2.49578336
131regulation of translational fidelity (GO:0006450)2.49397104
132tetrahydrofolate metabolic process (GO:0046653)2.49029788
133cardiac muscle cell development (GO:0055013)2.49019439
134IMP metabolic process (GO:0046040)2.47922465
135regulation of fibrinolysis (GO:0051917)2.47808961
136serine family amino acid metabolic process (GO:0009069)2.47658390
137regulation of posttranscriptional gene silencing (GO:0060147)2.47604564
138regulation of gene silencing by miRNA (GO:0060964)2.47604564
139regulation of gene silencing by RNA (GO:0060966)2.47604564
140membrane repolarization (GO:0086009)2.47434360
141transcription from mitochondrial promoter (GO:0006390)2.46818159
142metaphase plate congression (GO:0051310)2.46235452
143protein-lipid complex remodeling (GO:0034368)2.45881999
144macromolecular complex remodeling (GO:0034367)2.45881999
145plasma lipoprotein particle remodeling (GO:0034369)2.45881999
146ribosome biogenesis (GO:0042254)2.44744914
147cellular response to electrical stimulus (GO:0071257)2.44604852
148regulation of fatty acid beta-oxidation (GO:0031998)2.44597679
149serine family amino acid catabolic process (GO:0009071)2.40939757
150peptidyl-arginine omega-N-methylation (GO:0035247)2.40544835
151negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.40308668
152mitochondrial DNA metabolic process (GO:0032042)2.39932342
153fatty acid transmembrane transport (GO:1902001)2.39584610
154mitotic nuclear envelope disassembly (GO:0007077)2.39546045
155fatty acid oxidation (GO:0019395)2.39387682
156respiratory electron transport chain (GO:0022904)2.39264139
157maternal placenta development (GO:0001893)2.38630000
158branched-chain amino acid metabolic process (GO:0009081)2.38177747
159actin-myosin filament sliding (GO:0033275)2.37079790
160muscle filament sliding (GO:0030049)2.37079790
161negative regulation of RNA splicing (GO:0033119)2.36635053
162rRNA processing (GO:0006364)2.35991612
163* cellular component biogenesis (GO:0044085)2.35523965
164regulation of fatty acid oxidation (GO:0046320)2.34026797
165proline biosynthetic process (GO:0006561)2.33775400
166ethanol oxidation (GO:0006069)2.33362310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.24010023
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.97505230
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.69739289
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.48826458
5EZH2_22144423_ChIP-Seq_EOC_Human3.45094021
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.21242730
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93798307
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.82737675
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61446278
10* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.56759977
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55545254
12MYC_22102868_ChIP-Seq_BL_Human2.35789666
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35187799
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31794321
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31281901
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.23871239
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17139909
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16163764
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.13136111
20XRN2_22483619_ChIP-Seq_HELA_Human2.12897524
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12847691
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96215539
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88615769
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.83637745
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82126752
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.80951471
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79471429
28CIITA_25753668_ChIP-Seq_RAJI_Human1.78922695
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77081753
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.74019607
31DCP1A_22483619_ChIP-Seq_HELA_Human1.73201510
32ZNF274_21170338_ChIP-Seq_K562_Hela1.72591987
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72256745
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70550788
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70477198
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69195173
37VDR_21846776_ChIP-Seq_THP-1_Human1.66775951
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.65179633
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63557127
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59574201
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59263046
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58224708
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.57314571
44FOXP3_21729870_ChIP-Seq_TREG_Human1.57162774
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54804798
46ZNF263_19887448_ChIP-Seq_K562_Human1.54019493
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53198226
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50174480
49GABP_19822575_ChIP-Seq_HepG2_Human1.47824001
50VDR_23849224_ChIP-Seq_CD4+_Human1.47694958
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46497989
52TTF2_22483619_ChIP-Seq_HELA_Human1.46178734
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46145291
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45136509
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44663982
56* YY1_21170310_ChIP-Seq_MESCs_Mouse1.44040028
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43711082
58AR_21909140_ChIP-Seq_LNCAP_Human1.42051564
59P68_20966046_ChIP-Seq_HELA_Human1.40857067
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.37798992
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36040367
62VDR_22108803_ChIP-Seq_LS180_Human1.35213641
63STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.33632966
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33411525
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.33408933
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33248286
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32566438
68E2F1_20622854_ChIP-Seq_HELA_Human1.31302351
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.31088523
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30975537
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.30731419
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30272057
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.30022103
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.29534177
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29004242
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28639564
77CTCF_18555785_ChIP-Seq_MESCs_Mouse1.28275211
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28128376
79PHF8_20622854_ChIP-Seq_HELA_Human1.27853306
80KDM5A_27292631_Chip-Seq_BREAST_Human1.25836480
81* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25754648
82IRF1_19129219_ChIP-ChIP_H3396_Human1.25731409
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25176662
84* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24205933
85* SRF_21415370_ChIP-Seq_HL-1_Mouse1.21972010
86BCL6_27268052_Chip-Seq_Bcells_Human1.21301477
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21292536
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21261946
89ERA_21632823_ChIP-Seq_H3396_Human1.18341399
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17853368
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16968607
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15850685
93* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15495924
94FOXP1_21924763_ChIP-Seq_HESCs_Human1.15207610
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15139132
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14520463
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13618819
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12926574
99* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11683006
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.11190178
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10751675
102OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09694603
103RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08592530
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.07803164
105SA1_27219007_Chip-Seq_Bcells_Human1.06914129
106* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06832280
107PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06266394
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04792456
109IRF8_22096565_ChIP-ChIP_GC-B_Human1.03352998
110BCOR_27268052_Chip-Seq_Bcells_Human1.03291092
111SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.03271105
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03069569
113* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03003178
114HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02943558
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02502309
116TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02354561
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01863817
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.01418442
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01269453
120TP53_20018659_ChIP-ChIP_R1E_Mouse1.01022413
121TAF2_19829295_ChIP-Seq_ESCs_Human1.00850570
122* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00426744
123CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00408558
124STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00404643
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00352745
126CTCF_20526341_ChIP-Seq_ESCs_Human0.99653817
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.99610498
128SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99499232
129SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98217410
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98217301
131LXR_22292898_ChIP-Seq_THP-1_Human0.98070487
132RARB_24833708_ChIP-Seq_LIVER_Mouse0.97862770
133RAC3_21632823_ChIP-Seq_H3396_Human0.96545589
134SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96088896
135P300_27268052_Chip-Seq_Bcells_Human0.95164918
136MAF_26560356_Chip-Seq_TH1_Human0.94670078
137MYC_18940864_ChIP-ChIP_HL60_Human0.94665844
138FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94552620
139NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94481818
140KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94351032
141RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94291233
142SA1_27219007_Chip-Seq_ERYTHROID_Human0.94036644
143ATF3_27146783_Chip-Seq_COLON_Human0.93835170
144ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93340916
145NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92926111
146RARA_24833708_ChIP-Seq_LIVER_Mouse0.92059664
147TCF7_22412390_ChIP-Seq_EML_Mouse0.91967291
148GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91537039
149UTX_26944678_Chip-Seq_JUKART_Human0.91215947
150CBX2_27304074_Chip-Seq_ESCs_Mouse0.91024584
151* GATA3_21878914_ChIP-Seq_MCF-7_Human0.90195449
152CLOCK_20551151_ChIP-Seq_293T_Human0.90093452
153* HNF4A_19822575_ChIP-Seq_HepG2_Human0.89553078
154STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88635001
155LXR_22158963_ChIP-Seq_LIVER_Mouse0.88386678
156TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88373035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio3.51084597
2MP0003646_muscle_fatigue2.93397616
3MP0005360_urolithiasis2.82684273
4MP0003806_abnormal_nucleotide_metabolis2.74779064
5MP0004084_abnormal_cardiac_muscle2.71817685
6MP0004957_abnormal_blastocyst_morpholog2.62073413
7MP0003693_abnormal_embryo_hatching2.50876494
8MP0005330_cardiomyopathy2.22998011
9MP0002837_dystrophic_cardiac_calcinosis2.22414285
10MP0002139_abnormal_hepatobiliary_system2.18718455
11MP0005085_abnormal_gallbladder_physiolo2.16276868
12MP0006036_abnormal_mitochondrial_physio2.12333628
13MP0003077_abnormal_cell_cycle2.03774367
14MP0003111_abnormal_nucleus_morphology2.00083008
15MP0002396_abnormal_hematopoietic_system1.97883159
16MP0010094_abnormal_chromosome_stability1.95990253
17MP0003567_abnormal_fetal_cardiomyocyte1.92062795
18MP0006292_abnormal_olfactory_placode1.89781249
19MP0010030_abnormal_orbit_morphology1.88651262
20MP0000751_myopathy1.88321082
21MP0002938_white_spotting1.84382908
22MP0004215_abnormal_myocardial_fiber1.83326022
23MP0010630_abnormal_cardiac_muscle1.82668116
24MP0002160_abnormal_reproductive_system1.81359046
25MP0001873_stomach_inflammation1.80124302
26MP0005365_abnormal_bile_salt1.75608937
27MP0004036_abnormal_muscle_relaxation1.75028988
28MP0010368_abnormal_lymphatic_system1.74464601
29MP0003705_abnormal_hypodermis_morpholog1.70871498
30MP0002653_abnormal_ependyma_morphology1.70046244
31MP0003221_abnormal_cardiomyocyte_apopto1.67992028
32MP0004087_abnormal_muscle_fiber1.67613871
33MP0009333_abnormal_splenocyte_physiolog1.66732927
34MP0000749_muscle_degeneration1.65270295
35MP0003136_yellow_coat_color1.64265709
36MP0003122_maternal_imprinting1.62555095
37MP0009379_abnormal_foot_pigmentation1.62300096
38MP0005671_abnormal_response_to1.61140184
39MP0003195_calcinosis1.59850374
40MP0000685_abnormal_immune_system1.58706263
41MP0003828_pulmonary_edema1.56829636
42MP0002089_abnormal_postnatal_growth/wei1.56529433
43MP0001730_embryonic_growth_arrest1.56190576
44MP0004185_abnormal_adipocyte_glucose1.54742794
45MP0001666_abnormal_nutrient_absorption1.52727825
46MP0000566_synostosis1.52455792
47MP0004233_abnormal_muscle_weight1.52264196
48MP0003984_embryonic_growth_retardation1.51592670
49MP0002088_abnormal_embryonic_growth/wei1.49346481
50MP0001853_heart_inflammation1.47182519
51MP0002127_abnormal_cardiovascular_syste1.44835252
52MP0000750_abnormal_muscle_regeneration1.44098816
53MP0002269_muscular_atrophy1.42688590
54MP0008775_abnormal_heart_ventricle1.42271233
55MP0001672_abnormal_embryogenesis/_devel1.41547852
56MP0005380_embryogenesis_phenotype1.41547852
57MP0004142_abnormal_muscle_tone1.41511609
58MP0001544_abnormal_cardiovascular_syste1.40453452
59MP0005385_cardiovascular_system_phenoty1.40453452
60MP0006035_abnormal_mitochondrial_morpho1.36214918
61MP0009840_abnormal_foam_cell1.33379781
62MP0005408_hypopigmentation1.32510959
63MP0005451_abnormal_body_composition1.32334434
64MP0004130_abnormal_muscle_cell1.32123049
65MP0005319_abnormal_enzyme/_coenzyme1.30746081
66MP0001697_abnormal_embryo_size1.30139479
67MP0001800_abnormal_humoral_immune1.30017105
68MP0004742_abnormal_vestibular_system1.28193939
69MP0005332_abnormal_amino_acid1.27243669
70MP0001790_abnormal_immune_system1.26412758
71MP0005387_immune_system_phenotype1.26412758
72MP0002138_abnormal_hepatobiliary_system1.26339089
73MP0002876_abnormal_thyroid_physiology1.25876954
74MP0008007_abnormal_cellular_replicative1.21665320
75MP0002080_prenatal_lethality1.21535249
76MP0005670_abnormal_white_adipose1.20217549
77MP0001986_abnormal_taste_sensitivity1.19257089
78MP0005389_reproductive_system_phenotype1.18970028
79MP0002972_abnormal_cardiac_muscle1.18297920
80MP0001485_abnormal_pinna_reflex1.16893824
81MP0003123_paternal_imprinting1.15181245
82MP0002086_abnormal_extraembryonic_tissu1.14345647
83MP0000350_abnormal_cell_proliferation1.13454885
84MP0009278_abnormal_bone_marrow1.11671846
85MP0001663_abnormal_digestive_system1.11147341
86MP0008057_abnormal_DNA_replication1.11020847
87MP0006054_spinal_hemorrhage1.10351669
88MP0010352_gastrointestinal_tract_polyps1.10147241
89MP0005397_hematopoietic_system_phenotyp1.09699609
90MP0001545_abnormal_hematopoietic_system1.09699609
91MP0008932_abnormal_embryonic_tissue1.09696790
92MP0005266_abnormal_metabolism1.09224172
93MP0003186_abnormal_redox_activity1.08586966
94MP0008058_abnormal_DNA_repair1.07769992
95MP0005084_abnormal_gallbladder_morpholo1.07445290
96MP0005083_abnormal_biliary_tract1.07299041
97MP0002106_abnormal_muscle_physiology1.06920577
98MP0009384_cardiac_valve_regurgitation1.06726984
99MP0006138_congestive_heart_failure1.06135146
100MP0000266_abnormal_heart_morphology1.05821204
101MP0003011_delayed_dark_adaptation1.04706446
102MP0004019_abnormal_vitamin_homeostasis1.03547781
103MP0003950_abnormal_plasma_membrane1.01984678
104MP0000598_abnormal_liver_morphology1.01523253
105MP0003137_abnormal_impulse_conducting1.01437155
106MP0010329_abnormal_lipoprotein_level1.00942746
107MP0004808_abnormal_hematopoietic_stem1.00512829
108MP0002277_abnormal_respiratory_mucosa0.99871869
109MP0003879_abnormal_hair_cell0.99145254
110MP0008875_abnormal_xenobiotic_pharmacok0.99093824
111MP0000490_abnormal_crypts_of0.98900170
112MP0008995_early_reproductive_senescence0.97451827
113MP0009250_abnormal_appendicular_skeleto0.96363023
114MP0009672_abnormal_birth_weight0.96125689
115MP0000609_abnormal_liver_physiology0.96033755
116MP0002085_abnormal_embryonic_tissue0.95637268
117MP0003191_abnormal_cellular_cholesterol0.95013128
118MP0002019_abnormal_tumor_incidence0.94972291
119MP0005076_abnormal_cell_differentiation0.93215214
120MP0000747_muscle_weakness0.92025468
121MP0005379_endocrine/exocrine_gland_phen0.90703246
122MP0000049_abnormal_middle_ear0.90650099
123MP0002163_abnormal_gland_morphology0.90181124
124MP0005666_abnormal_adipose_tissue0.89741496
125MP0000313_abnormal_cell_death0.89633709
126MP0004197_abnormal_fetal_growth/weight/0.89344640
127MP0005620_abnormal_muscle_contractility0.89325023
128MP0005310_abnormal_salivary_gland0.88424613
129MP0003252_abnormal_bile_duct0.87721433
130MP0005448_abnormal_energy_balance0.87466615
131MP0003436_decreased_susceptibility_to0.86113787
132MP0005058_abnormal_lysosome_morphology0.85373420
133MP0001764_abnormal_homeostasis0.85120036
134MP0000631_abnormal_neuroendocrine_gland0.85010825
135MP0003315_abnormal_perineum_morphology0.84737664
136MP0000372_irregular_coat_pigmentation0.84244143
137MP0000759_abnormal_skeletal_muscle0.83939590
138MP0003938_abnormal_ear_development0.83637506
139MP0009053_abnormal_anal_canal0.83227679
140MP0002084_abnormal_developmental_patter0.81554841
141MP0005551_abnormal_eye_electrophysiolog0.81014415
142MP0004133_heterotaxia0.80150464
143MP0003566_abnormal_cell_adhesion0.79884936
144MP0003890_abnormal_embryonic-extraembry0.79277575
145MP0000026_abnormal_inner_ear0.79015842
146MP0009643_abnormal_urine_homeostasis0.78673249
147MP0003941_abnormal_skin_development0.78362976
148MP0002128_abnormal_blood_circulation0.77646859
149MP0002332_abnormal_exercise_endurance0.77518739
150MP0002132_abnormal_respiratory_system0.77201848
151MP0001324_abnormal_eye_pigmentation0.76966328
152MP0002118_abnormal_lipid_homeostasis0.75343882
153MP0008872_abnormal_physiological_respon0.73684926
154MP0002723_abnormal_immune_serum0.72999487
155MP0001915_intracranial_hemorrhage0.72613646
156MP0005369_muscle_phenotype0.72369422
157MP0009765_abnormal_xenobiotic_induced0.71260953
158MP0009642_abnormal_blood_homeostasis0.68951310
159MP0003942_abnormal_urinary_system0.67916609
160MP0003959_abnormal_lean_body0.67533796
161MP0002933_joint_inflammation0.67396421
162MP0004885_abnormal_endolymph0.65942960
163MP0003718_maternal_effect0.64508982
164MP0005381_digestive/alimentary_phenotyp0.63950218
165MP0001440_abnormal_grooming_behavior0.63802760
166MP0001348_abnormal_lacrimal_gland0.63317654
167MP0002210_abnormal_sex_determination0.63242923

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)3.73413473
2Ventricular tachycardia (HP:0004756)3.67534878
3Myoglobinuria (HP:0002913)3.62115616
4Sudden death (HP:0001699)3.61860435
5Hepatic necrosis (HP:0002605)3.57858681
6Rhabdomyolysis (HP:0003201)3.45919093
7Multiple enchondromatosis (HP:0005701)3.43976763
8Reticulocytopenia (HP:0001896)3.39654061
9Hyperammonemia (HP:0001987)3.39166075
10Abnormality of cells of the erythroid lineage (HP:0012130)3.34141871
11Cerebral palsy (HP:0100021)3.23585469
12Exercise-induced muscle cramps (HP:0003710)3.18413429
13Abnormality of dicarboxylic acid metabolism (HP:0010995)3.12399135
14Dicarboxylic aciduria (HP:0003215)3.12399135
15Osteomalacia (HP:0002749)3.11668135
16Abnormal number of erythroid precursors (HP:0012131)3.10821174
17Hyperglycinuria (HP:0003108)3.09572523
18Increased muscle lipid content (HP:0009058)3.08421964
19Hepatocellular necrosis (HP:0001404)3.04804559
20Abnormality of fatty-acid metabolism (HP:0004359)3.04286273
213-Methylglutaconic aciduria (HP:0003535)2.99798246
22Nausea (HP:0002018)2.98869443
23Hypoglycemic coma (HP:0001325)2.91405427
24Clumsiness (HP:0002312)2.85061503
25Lipoatrophy (HP:0100578)2.84242082
26Generalized aminoaciduria (HP:0002909)2.83913472
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.81521990
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.81521990
29Short femoral neck (HP:0100864)2.79172825
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.77766148
31Abnormality of alanine metabolism (HP:0010916)2.77766148
32Hyperalaninemia (HP:0003348)2.77766148
33Ragged-red muscle fibers (HP:0003200)2.76792876
34Abnormality of serine family amino acid metabolism (HP:0010894)2.75723490
35Abnormality of glycine metabolism (HP:0010895)2.75723490
36Abnormality of pyrimidine metabolism (HP:0004353)2.73956320
37Increased intramyocellular lipid droplets (HP:0012240)2.71910680
38Short tibia (HP:0005736)2.67739953
39Exercise-induced myalgia (HP:0003738)2.66242265
40Hyperglycinemia (HP:0002154)2.64929856
41Palpitations (HP:0001962)2.64375548
42Prolonged partial thromboplastin time (HP:0003645)2.63099782
43Ulnar deviation of the wrist (HP:0003049)2.61618233
44Macrocytic anemia (HP:0001972)2.56843594
45Asymmetric septal hypertrophy (HP:0001670)2.55353122
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54955106
47Acute necrotizing encephalopathy (HP:0006965)2.54643757
48Dilated cardiomyopathy (HP:0001644)2.51280446
49Aplasia/Hypoplasia of the patella (HP:0006498)2.51036865
50Increased serum pyruvate (HP:0003542)2.50321637
51Abnormality of glycolysis (HP:0004366)2.50321637
52Muscle fiber inclusion bodies (HP:0100299)2.49256328
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.47969104
54Paralysis (HP:0003470)2.47078393
55Hypobetalipoproteinemia (HP:0003563)2.45847702
56Ketosis (HP:0001946)2.43531524
57Lactic acidosis (HP:0003128)2.40907550
58Subaortic stenosis (HP:0001682)2.40466282
59Abnormality of the left ventricular outflow tract (HP:0011103)2.40466282
60Patellar aplasia (HP:0006443)2.40235948
61Nemaline bodies (HP:0003798)2.40224667
62Calf muscle hypertrophy (HP:0008981)2.39420026
63Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.39260878
64Increased serum lactate (HP:0002151)2.38326057
65Abnormality of the renal collecting system (HP:0004742)2.35228776
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.32884085
67Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.31068929
68Acute encephalopathy (HP:0006846)2.30714664
69Abnormality of serum amino acid levels (HP:0003112)2.28479123
70Angiofibromas (HP:0010615)2.28358835
71Adenoma sebaceum (HP:0009720)2.28358835
72Decreased circulating renin level (HP:0003351)2.28019937
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.25344968
74Abolished electroretinogram (ERG) (HP:0000550)2.24764172
75Renal Fanconi syndrome (HP:0001994)2.24635669
76Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21592435
77Decreased subcutaneous fat (HP:0001002)2.19576834
78Joint hemorrhage (HP:0005261)2.16913943
79Supraventricular tachycardia (HP:0004755)2.16820047
80Cerebral edema (HP:0002181)2.16434119
81Increased CSF lactate (HP:0002490)2.15615433
82Ketoacidosis (HP:0001993)2.14282480
83Atrial fibrillation (HP:0005110)2.14237479
84Supraventricular arrhythmia (HP:0005115)2.12593929
85Lipid accumulation in hepatocytes (HP:0006561)2.11750008
86Muscle hypertrophy of the lower extremities (HP:0008968)2.09559513
87Pallor (HP:0000980)2.09488693
88Congenital, generalized hypertrichosis (HP:0004540)2.09182886
89Right ventricular cardiomyopathy (HP:0011663)2.08999679
90Lethargy (HP:0001254)2.07240507
91Absent phalangeal crease (HP:0006109)2.07145607
92Conjunctival hamartoma (HP:0100780)2.06730691
93Genu varum (HP:0002970)2.05419763
94Increased connective tissue (HP:0009025)2.05223803
95Oral leukoplakia (HP:0002745)2.04218841
96Primary atrial arrhythmia (HP:0001692)2.03555587
97Fibular hypoplasia (HP:0003038)2.02487623
98Abnormality of reticulocytes (HP:0004312)2.02371887
99Testicular atrophy (HP:0000029)2.02206218
100Atrioventricular block (HP:0001678)2.00172677
101Mitochondrial inheritance (HP:0001427)1.99125964
102Hypoplasia of the ulna (HP:0003022)1.97789207
103Aplasia/Hypoplasia of the fibula (HP:0006492)1.96885652
104Panhypogammaglobulinemia (HP:0003139)1.96355763
105Concave nail (HP:0001598)1.96100920
106Mesangial abnormality (HP:0001966)1.95812891
107Cortical visual impairment (HP:0100704)1.95654129
108Aplasia/hypoplasia of the femur (HP:0005613)1.94563136
109Metabolic acidosis (HP:0001942)1.94546237
110Intrahepatic cholestasis (HP:0001406)1.94358663
111Megalencephaly (HP:0001355)1.92957791
112Abnormal cartilage morphology (HP:0002763)1.92370630
113Colon cancer (HP:0003003)1.90696414
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89991366
115Optic disc pallor (HP:0000543)1.89111589
116Neoplasm of the adrenal gland (HP:0100631)1.88768122
117Xanthomatosis (HP:0000991)1.88083531
118Hypolipoproteinemia (HP:0010981)1.87966580
119Periauricular skin pits (HP:0100277)1.87631592
120Preauricular pit (HP:0004467)1.87631592
121Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.87347707
122Short 4th metacarpal (HP:0010044)1.87083318
123Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87083318
124Respiratory failure (HP:0002878)1.84912858
125Diastasis recti (HP:0001540)1.84911969
126Ependymoma (HP:0002888)1.84421688
127CNS demyelination (HP:0007305)1.84017145
128Abnormality of lateral ventricle (HP:0030047)1.83849397
129Ventricular arrhythmia (HP:0004308)1.82950722
130Proximal tubulopathy (HP:0000114)1.82711206
131Delayed CNS myelination (HP:0002188)1.82439773
132Neonatal death (HP:0003811)1.81869765
133Abnormality of DNA repair (HP:0003254)1.81262891
134Thrombocytosis (HP:0001894)1.81175115
135Glycosuria (HP:0003076)1.80302672
136Abnormality of urine glucose concentration (HP:0011016)1.80302672
137Hypoplasia of the uterus (HP:0000013)1.79968021
138Fibular aplasia (HP:0002990)1.78481614
139Enlarged kidneys (HP:0000105)1.78464008
140Hypoplasia of the radius (HP:0002984)1.78192309
141Progressive macrocephaly (HP:0004481)1.77102234
142Esophageal neoplasm (HP:0100751)1.76735961
143Neoplasm of head and neck (HP:0012288)1.76735961
144Abnormality of the nasal septum (HP:0000419)1.76189224
145Abnormal hemoglobin (HP:0011902)1.75990851
146Stenosis of the external auditory canal (HP:0000402)1.75567891
147Confusion (HP:0001289)1.74680187
148Abnormal urine phosphate concentration (HP:0012599)1.73694678
149Distal arthrogryposis (HP:0005684)1.73620870
150Respiratory difficulties (HP:0002880)1.72826074
151Abnormal pupillary function (HP:0007686)1.72273511
152Hyperbilirubinemia (HP:0002904)1.72114326
153Supernumerary bones of the axial skeleton (HP:0009144)1.71451703
154Progressive muscle weakness (HP:0003323)1.70906539
155Vomiting (HP:0002013)1.70769950
156Polycythemia (HP:0001901)1.70149193
157Rectal prolapse (HP:0002035)1.69797191
158Absent thumb (HP:0009777)1.69570945
159Increased hepatocellular lipid droplets (HP:0006565)1.69054832
160Abnormal mitochondria in muscle tissue (HP:0008316)1.68942866
161Exercise intolerance (HP:0003546)1.68891138
162Congenital stationary night blindness (HP:0007642)1.68838261
163Patent foramen ovale (HP:0001655)1.68639107
164Abnormality of the calf musculature (HP:0001430)1.68423835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.54881386
2BCKDK4.39394564
3TRIB33.65946533
4WNK43.13155197
5NME22.70974250
6NEK12.69658015
7MAP3K102.67223996
8NME12.39953886
9TYRO32.30847801
10ERN12.30041712
11FLT32.28652971
12CAMKK22.18304655
13WEE12.05628853
14TTN2.04396122
15BUB12.02191628
16PASK2.00652600
17SIK21.90852775
18VRK21.89980037
19NEK21.75348162
20EEF2K1.75048398
21MYLK1.70906280
22CDK121.70323341
23KDR1.63403036
24MAP2K31.57037185
25LMTK21.52625024
26TAF11.51214291
27TGFBR11.50486540
28ACVR1B1.50184261
29RPS6KB21.46999498
30TTK1.38841989
31CDK71.38250578
32PIK3CA1.37195969
33CDK41.36263628
34PAK41.36045620
35CDC71.34808533
36MAP4K11.34612317
37OBSCN1.33798531
38FGFR31.33021600
39ADRBK21.31776952
40MAPK151.28149720
41CDK191.26977148
42TLK11.26848602
43LRRK21.26780256
44ILK1.22845531
45RIPK41.22733280
46PDK41.22447137
47PDK31.22447137
48ITK1.18735076
49VRK11.16731578
50CDK81.13932706
51TAOK31.12775602
52STK241.12526615
53IKBKB1.10523422
54AURKB1.08212833
55CAMKK11.07012958
56STK41.06628271
57MAP3K111.06312884
58STK391.04411784
59GRK11.03960086
60STK38L1.02292119
61PLK10.97580393
62MAPK110.97496753
63CAMK40.97459247
64MAPKAPK30.96947107
65KIT0.95871354
66MATK0.94562047
67WNK10.91114889
68SYK0.90830514
69STK100.89242608
70DYRK20.88607873
71SIK10.88298730
72MAPKAPK50.87960777
73RPS6KC10.87145836
74RPS6KL10.87145836
75MAP3K80.86617127
76RPS6KA20.85534966
77PIM20.85348887
78PHKG20.84471870
79PHKG10.84471870
80TYK20.84321820
81IRAK40.83808112
82TGFBR20.83804677
83SIK30.82816583
84SGK20.82309684
85SMG10.82016746
86GRK60.81000961
87TNK20.80757656
88CSF1R0.79812488
89EIF2AK10.77613371
90RPS6KA60.77383526
91ATR0.76935670
92ZAP700.75361991
93RPS6KA40.75325417
94TIE10.74914460
95SGK2230.74242680
96SGK4940.74242680
97TESK20.74186879
98INSRR0.73670900
99PINK10.73313280
100ALK0.71288771
101AKT20.69532217
102PRKD20.69309070
103BMPR1B0.69162058
104DYRK30.68604876
105CDK60.66926606
106STK160.66700546
107MARK30.65804504
108PIM10.64386057
109PRKCQ0.63121426
110LYN0.62794184
111TSSK60.62426385
112MTOR0.62110585
113MAPK70.61017275
114TAOK10.60955952
115LCK0.60382192
116PRKAA20.58756953
117MAP2K60.58123186
118BTK0.57352470
119DAPK30.57164516
120HIPK20.56684796
121NEK90.55939819
122PTK60.55817508
123MAP2K20.54997108
124FGFR40.54866953
125RPS6KA10.52688777
126TAOK20.52540322
127RPS6KA50.51587791
128PRKACA0.51236147
129CSNK2A20.48501126
130EPHA20.48393952
131PIK3CG0.47083575
132MAP3K70.46127954
133CAMK10.45338218
134TBK10.44967481
135STK110.44506830
136FRK0.44432903
137CSK0.43284433
138CSNK2A10.42476104
139LATS20.42150897
140AURKA0.41249885
141CDK20.41043504
142PDK20.40716837
143MKNK10.39803079
144MAPK120.39462199
145CHEK10.36663860
146BRSK20.36401495
147ICK0.35350521
148EPHB20.33516015
149CCNB10.33224253
150NLK0.32580679
151ZAK0.31691209
152DMPK0.31352920
153PRKG20.30874525
154PRKAA10.30433348
155PRKD10.29151461
156MAPK40.28411417

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.68463618
2Ribosome_Homo sapiens_hsa030103.58898896
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.48936326
4DNA replication_Homo sapiens_hsa030302.92132859
5Vitamin digestion and absorption_Homo sapiens_hsa049772.70667716
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52831145
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52127764
8Fatty acid degradation_Homo sapiens_hsa000712.43924837
9Mismatch repair_Homo sapiens_hsa034302.37405262
10Carbon metabolism_Homo sapiens_hsa012002.35924144
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.33492632
12Propanoate metabolism_Homo sapiens_hsa006402.24565840
13One carbon pool by folate_Homo sapiens_hsa006702.23647907
14Asthma_Homo sapiens_hsa053102.15869329
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11234399
16Base excision repair_Homo sapiens_hsa034102.08425202
17Biosynthesis of amino acids_Homo sapiens_hsa012302.06244726
18Spliceosome_Homo sapiens_hsa030401.76809513
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.75366786
20Pyruvate metabolism_Homo sapiens_hsa006201.71730407
21Fatty acid metabolism_Homo sapiens_hsa012121.70873484
22Parkinsons disease_Homo sapiens_hsa050121.65346373
23Proteasome_Homo sapiens_hsa030501.65256869
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.54565572
25Allograft rejection_Homo sapiens_hsa053301.52382581
26RNA transport_Homo sapiens_hsa030131.51698284
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47262809
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46464076
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.41589814
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41514987
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.40195368
32Homologous recombination_Homo sapiens_hsa034401.39903708
33Sulfur relay system_Homo sapiens_hsa041221.39083777
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38764326
35RNA polymerase_Homo sapiens_hsa030201.37851179
36Staphylococcus aureus infection_Homo sapiens_hsa051501.37797696
37Linoleic acid metabolism_Homo sapiens_hsa005911.37144703
38Autoimmune thyroid disease_Homo sapiens_hsa053201.37114303
39Arginine biosynthesis_Homo sapiens_hsa002201.36814526
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36084522
41Tryptophan metabolism_Homo sapiens_hsa003801.35355116
42Pyrimidine metabolism_Homo sapiens_hsa002401.34987140
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33187111
44Nucleotide excision repair_Homo sapiens_hsa034201.30908331
45Pentose phosphate pathway_Homo sapiens_hsa000301.26864178
46Oxidative phosphorylation_Homo sapiens_hsa001901.26547877
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.23514301
48Lysine degradation_Homo sapiens_hsa003101.22109592
49Folate biosynthesis_Homo sapiens_hsa007901.20672697
50Primary immunodeficiency_Homo sapiens_hsa053401.19147903
51Graft-versus-host disease_Homo sapiens_hsa053321.16603814
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14844484
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14564492
54Cardiac muscle contraction_Homo sapiens_hsa042601.12929350
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10947918
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10223797
57Huntingtons disease_Homo sapiens_hsa050161.04377379
58Cell cycle_Homo sapiens_hsa041101.02883611
59Peroxisome_Homo sapiens_hsa041461.02377096
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02328002
61Selenocompound metabolism_Homo sapiens_hsa004501.02019091
62PPAR signaling pathway_Homo sapiens_hsa033201.00809794
63Butanoate metabolism_Homo sapiens_hsa006501.00765634
64Galactose metabolism_Homo sapiens_hsa000521.00660268
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96133137
66beta-Alanine metabolism_Homo sapiens_hsa004100.94607976
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91244620
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88943768
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85944399
70Fructose and mannose metabolism_Homo sapiens_hsa000510.85569344
71RNA degradation_Homo sapiens_hsa030180.82088447
72Regulation of autophagy_Homo sapiens_hsa041400.77075487
73Alzheimers disease_Homo sapiens_hsa050100.76440866
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76264531
75Arginine and proline metabolism_Homo sapiens_hsa003300.75111451
76Glycerolipid metabolism_Homo sapiens_hsa005610.75016086
77mRNA surveillance pathway_Homo sapiens_hsa030150.73703848
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70163351
79Starch and sucrose metabolism_Homo sapiens_hsa005000.67993951
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67255023
81Nitrogen metabolism_Homo sapiens_hsa009100.66028452
82Fat digestion and absorption_Homo sapiens_hsa049750.65861111
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.65761409
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65692717
85Sulfur metabolism_Homo sapiens_hsa009200.64144435
86Ether lipid metabolism_Homo sapiens_hsa005650.62939044
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62664878
88Antigen processing and presentation_Homo sapiens_hsa046120.60448788
89Thyroid cancer_Homo sapiens_hsa052160.59938485
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58808626
91Glutathione metabolism_Homo sapiens_hsa004800.58515846
92Steroid biosynthesis_Homo sapiens_hsa001000.58405886
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57384053
94Fatty acid elongation_Homo sapiens_hsa000620.56906939
95p53 signaling pathway_Homo sapiens_hsa041150.56357937
96Arachidonic acid metabolism_Homo sapiens_hsa005900.55861216
97Non-homologous end-joining_Homo sapiens_hsa034500.53390132
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53215141
99Purine metabolism_Homo sapiens_hsa002300.52647537
100Viral myocarditis_Homo sapiens_hsa054160.51298449
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.50927883
102Type I diabetes mellitus_Homo sapiens_hsa049400.49609061
103Renin-angiotensin system_Homo sapiens_hsa046140.48891609
104Histidine metabolism_Homo sapiens_hsa003400.48419016
105Metabolic pathways_Homo sapiens_hsa011000.47188973
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44772630
107Leishmaniasis_Homo sapiens_hsa051400.42918728
108Phenylalanine metabolism_Homo sapiens_hsa003600.42215553
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.41424099
110Herpes simplex infection_Homo sapiens_hsa051680.40988925
111AMPK signaling pathway_Homo sapiens_hsa041520.40967620
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39063251
113Dilated cardiomyopathy_Homo sapiens_hsa054140.39003584
114Phototransduction_Homo sapiens_hsa047440.38330916
115Insulin resistance_Homo sapiens_hsa049310.37894666
116Fatty acid biosynthesis_Homo sapiens_hsa000610.37611305
117ABC transporters_Homo sapiens_hsa020100.37381204
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37346987
119Epstein-Barr virus infection_Homo sapiens_hsa051690.36659824
120Acute myeloid leukemia_Homo sapiens_hsa052210.35228824
121HTLV-I infection_Homo sapiens_hsa051660.35049497
122Complement and coagulation cascades_Homo sapiens_hsa046100.34678727
123B cell receptor signaling pathway_Homo sapiens_hsa046620.33433034
124Chemical carcinogenesis_Homo sapiens_hsa052040.33429618
125HIF-1 signaling pathway_Homo sapiens_hsa040660.33020442
126Notch signaling pathway_Homo sapiens_hsa043300.32168277
127Fanconi anemia pathway_Homo sapiens_hsa034600.32076809
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31303745
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.30665680
130Small cell lung cancer_Homo sapiens_hsa052220.29371718
131MAPK signaling pathway_Homo sapiens_hsa040100.28710139
132Basal transcription factors_Homo sapiens_hsa030220.28594579
133* Protein export_Homo sapiens_hsa030600.26449990
134Caffeine metabolism_Homo sapiens_hsa002320.26213966
135Tyrosine metabolism_Homo sapiens_hsa003500.25787155
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.25294613
137Retinol metabolism_Homo sapiens_hsa008300.25169274
138Basal cell carcinoma_Homo sapiens_hsa052170.23788695
139Insulin signaling pathway_Homo sapiens_hsa049100.23337821
140Glucagon signaling pathway_Homo sapiens_hsa049220.22980042
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22731478

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