OXCT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.19976372
2positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.81470300
3nuclear pore organization (GO:0006999)4.74989316
4regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.54477250
5tricarboxylic acid cycle (GO:0006099)4.53710691
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.42289630
7regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.40703837
8DNA unwinding involved in DNA replication (GO:0006268)4.26466865
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.25840358
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.09009742
11pore complex assembly (GO:0046931)4.06185890
12regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.05523722
13cell communication by electrical coupling (GO:0010644)4.05370730
14regulation of cell communication by electrical coupling (GO:0010649)3.97760121
15regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.87805622
16regulation of acyl-CoA biosynthetic process (GO:0050812)3.87783655
17cardiac myofibril assembly (GO:0055003)3.86115743
18negative regulation of potassium ion transmembrane transport (GO:1901380)3.84150178
19cell communication involved in cardiac conduction (GO:0086065)3.73889117
20regulation of coenzyme metabolic process (GO:0051196)3.65876062
21regulation of cofactor metabolic process (GO:0051193)3.65876062
22positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.61434034
23plasma membrane repair (GO:0001778)3.60524887
24sodium ion export (GO:0071436)3.59724427
25cellular potassium ion homeostasis (GO:0030007)3.58503177
26locomotory exploration behavior (GO:0035641)3.56747268
27vocalization behavior (GO:0071625)3.56149302
28mitotic chromosome condensation (GO:0007076)3.54723892
29regulation of synapse structural plasticity (GO:0051823)3.54213038
30synaptic vesicle maturation (GO:0016188)3.52803913
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.50854107
32double-strand break repair via nonhomologous end joining (GO:0006303)3.48487933
33non-recombinational repair (GO:0000726)3.48487933
34sarcomere organization (GO:0045214)3.47163164
35membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.45738996
36mitotic sister chromatid segregation (GO:0000070)3.44982625
37layer formation in cerebral cortex (GO:0021819)3.43546296
38regulation of membrane repolarization (GO:0060306)3.43072537
39DNA strand elongation involved in DNA replication (GO:0006271)3.42602295
40cardiac muscle contraction (GO:0060048)3.42098137
41regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.41190204
42positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.39079644
43sister chromatid segregation (GO:0000819)3.36736766
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36644293
45regulation of actin filament-based movement (GO:1903115)3.32104156
46relaxation of cardiac muscle (GO:0055119)3.30467263
47IMP biosynthetic process (GO:0006188)3.30074862
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.29378982
49DNA strand elongation (GO:0022616)3.29169256
50synaptic vesicle exocytosis (GO:0016079)3.29000945
51positive regulation of potassium ion transmembrane transport (GO:1901381)3.27471401
52sarcoplasmic reticulum calcium ion transport (GO:0070296)3.27260685
53establishment of integrated proviral latency (GO:0075713)3.22726595
54detection of calcium ion (GO:0005513)3.22719775
55regulation of translational fidelity (GO:0006450)3.21331322
56NADH metabolic process (GO:0006734)3.18438347
57myofibril assembly (GO:0030239)3.17771454
58potassium ion import (GO:0010107)3.14789927
59proline transport (GO:0015824)3.14645938
60regulation of calcium ion transmembrane transport (GO:1903169)3.14070840
61regulation of calcium ion transmembrane transporter activity (GO:1901019)3.14070840
62regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.14064235
63regulation of mitotic spindle organization (GO:0060236)3.10953585
64membrane repolarization during action potential (GO:0086011)3.09921913
65regulation of relaxation of muscle (GO:1901077)3.07082931
66activation of protein kinase A activity (GO:0034199)3.05259347
67succinate metabolic process (GO:0006105)3.04992762
68membrane repolarization (GO:0086009)3.03224774
69mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.02519280
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.01947369
71formation of translation preinitiation complex (GO:0001731)3.00912751
72tRNA aminoacylation for protein translation (GO:0006418)3.00611184
73mitotic sister chromatid cohesion (GO:0007064)2.99479621
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.99422580
75glutamate secretion (GO:0014047)2.98904565
76IMP metabolic process (GO:0046040)2.98128810
77regulation of potassium ion transmembrane transporter activity (GO:1901016)2.96789683
78regulation of glutamate receptor signaling pathway (GO:1900449)2.95188932
79regulation of potassium ion transmembrane transport (GO:1901379)2.93506633
80regulation of cardiac muscle cell contraction (GO:0086004)2.93490663
81telomere maintenance via semi-conservative replication (GO:0032201)2.92393652
82amino acid activation (GO:0043038)2.90454571
83tRNA aminoacylation (GO:0043039)2.90454571
84positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89732921
85positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89732921
86positive regulation of mitotic sister chromatid separation (GO:1901970)2.89732921
87purine nucleobase biosynthetic process (GO:0009113)2.89431295
88regulation of synaptic vesicle exocytosis (GO:2000300)2.87640889
89ventricular cardiac muscle cell action potential (GO:0086005)2.87496671
90exploration behavior (GO:0035640)2.86907386
91positive regulation of chromosome segregation (GO:0051984)2.83521311
92nucleobase-containing small molecule interconversion (GO:0015949)2.83424691
93establishment of mitochondrion localization (GO:0051654)2.81760393
94nucleotide-excision repair, DNA gap filling (GO:0006297)2.79835598
95regulation of sulfur metabolic process (GO:0042762)2.79452213
96homocysteine metabolic process (GO:0050667)2.77340795
97positive regulation of potassium ion transport (GO:0043268)2.76229882
98folic acid metabolic process (GO:0046655)2.75813200
99positive regulation of vascular permeability (GO:0043117)2.75368684
100mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75344042
101nuclear envelope disassembly (GO:0051081)2.75315582
102membrane disassembly (GO:0030397)2.75315582
103respiratory electron transport chain (GO:0022904)2.74918808
104protein localization to synapse (GO:0035418)2.74125783
105ATP synthesis coupled proton transport (GO:0015986)2.73999025
106energy coupled proton transport, down electrochemical gradient (GO:0015985)2.73999025
107lysine metabolic process (GO:0006553)2.73851822
108lysine catabolic process (GO:0006554)2.73851822
109DNA replication initiation (GO:0006270)2.71509768
110telomere maintenance via recombination (GO:0000722)2.71367288
111deoxyribonucleotide biosynthetic process (GO:0009263)2.70990524
112synaptic vesicle docking involved in exocytosis (GO:0016081)2.70780431
113positive regulation of cation channel activity (GO:2001259)2.70719364
114mitotic nuclear envelope disassembly (GO:0007077)2.70706102
115regulation of cation channel activity (GO:2001257)2.69624279
116carnitine transport (GO:0015879)2.67514383
117amino-acid betaine transport (GO:0015838)2.67514383
118regulation of striated muscle contraction (GO:0006942)2.67180623
119electron transport chain (GO:0022900)2.66867029
120carnitine shuttle (GO:0006853)2.66773799
121protein localization to chromosome, centromeric region (GO:0071459)2.66496392
122positive regulation of dendritic spine morphogenesis (GO:0061003)2.65789197
123regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65516060
124regulation of RNA export from nucleus (GO:0046831)2.63928992
125neuron cell-cell adhesion (GO:0007158)2.62889191
126regulation of sister chromatid cohesion (GO:0007063)2.62508350
127establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.61351204
128mitochondrion transport along microtubule (GO:0047497)2.61351204
129cardiac conduction (GO:0061337)2.61270994
130dendritic spine morphogenesis (GO:0060997)2.60768733
131neurotransmitter secretion (GO:0007269)2.60659437
132oxidative phosphorylation (GO:0006119)2.60538881
133mitotic recombination (GO:0006312)2.60516345
134regulation of cardiac muscle contraction (GO:0055117)2.59856336
135neuron recognition (GO:0008038)2.59699800
136regulation of voltage-gated calcium channel activity (GO:1901385)2.59621223
137neuronal action potential propagation (GO:0019227)2.58826077
138regulation of synaptic vesicle transport (GO:1902803)2.58603041
139regulation of sarcomere organization (GO:0060297)2.57723421
140striated muscle contraction (GO:0006941)2.57120106
141quaternary ammonium group transport (GO:0015697)2.56780826
142regulation of dendritic spine morphogenesis (GO:0061001)2.55562682
143dendrite morphogenesis (GO:0048813)2.55059342
144metanephric nephron tubule development (GO:0072234)2.54440653
145metanephric tubule development (GO:0072170)2.54440653
146positive regulation of sodium ion transport (GO:0010765)2.52642019
147tricarboxylic acid metabolic process (GO:0072350)2.52136918
148ribosome assembly (GO:0042255)2.51509320
149protein localization to kinetochore (GO:0034501)2.50732768
150cellular protein complex localization (GO:0034629)2.50442415
151aspartate family amino acid catabolic process (GO:0009068)2.49654338
152oxaloacetate metabolic process (GO:0006107)2.49224639
153glutamine metabolic process (GO:0006541)2.47651392
154regulation of spindle organization (GO:0090224)2.46062160
155negative regulation of neurotransmitter secretion (GO:0046929)2.42902003
156nucleobase biosynthetic process (GO:0046112)2.42619880
157mitotic metaphase plate congression (GO:0007080)2.42201077
158righting reflex (GO:0060013)2.38042476
159regulation of nucleobase-containing compound transport (GO:0032239)2.37446188
160regulation of translational elongation (GO:0006448)2.36041804
161meiotic chromosome segregation (GO:0045132)2.33788441
162translesion synthesis (GO:0019985)2.33268632
163DNA synthesis involved in DNA repair (GO:0000731)2.31907647

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.27783985
2EZH2_22144423_ChIP-Seq_EOC_Human4.52906019
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.28704743
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.02480223
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.64204194
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01838081
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.85843825
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84787997
9GBX2_23144817_ChIP-Seq_PC3_Human2.81001227
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79578105
11AR_21909140_ChIP-Seq_LNCAP_Human2.76304291
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72075844
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63501453
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52063004
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52063004
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48264999
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46517912
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45390305
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44505518
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41811371
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39102195
22* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.34857332
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31522534
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27876287
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26051372
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24261606
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.23826187
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23663564
29JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22252442
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19516673
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16304508
32* DROSHA_22980978_ChIP-Seq_HELA_Human2.15925957
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15639142
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14973900
35EP300_21415370_ChIP-Seq_HL-1_Mouse2.14633744
36* E2F1_21310950_ChIP-Seq_MCF-7_Human2.14013153
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13303079
38MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12418862
39* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.04200496
40AR_21572438_ChIP-Seq_LNCaP_Human2.02674951
41RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00377088
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.99650594
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.95930519
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.94757436
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.94219327
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90042283
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.87099246
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86839492
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78468659
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.78293601
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76894220
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76126847
53XRN2_22483619_ChIP-Seq_HELA_Human1.75197729
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69927343
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.68826801
56REST_21632747_ChIP-Seq_MESCs_Mouse1.67784912
57DCP1A_22483619_ChIP-Seq_HELA_Human1.64870275
58ELK1_19687146_ChIP-ChIP_HELA_Human1.61222367
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61103994
60ZNF274_21170338_ChIP-Seq_K562_Hela1.59510085
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.58563202
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.54420788
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54377498
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53344073
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52381396
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.50670854
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50628549
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50043812
69* SMAD4_21799915_ChIP-Seq_A2780_Human1.49787151
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49695506
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48997135
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.45509571
73* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41647634
74* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.41496058
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.40734168
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.39721184
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39177705
78* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38510083
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38125497
80SOX9_26525672_Chip-Seq_HEART_Mouse1.37619266
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.36819205
82TTF2_22483619_ChIP-Seq_HELA_Human1.36277128
83EST1_17652178_ChIP-ChIP_JURKAT_Human1.36126277
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35234860
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.34043057
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33721664
87* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32613209
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32395295
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31986805
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31817971
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29873553
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29060400
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28446839
94TBX20_22328084_ChIP-Seq_HEART_Mouse1.27658259
95TBX20_22080862_ChIP-Seq_HEART_Mouse1.27658259
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27360957
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26945891
98GABP_17652178_ChIP-ChIP_JURKAT_Human1.26735280
99* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26573217
100IGF1R_20145208_ChIP-Seq_DFB_Human1.25791925
101FUS_26573619_Chip-Seq_HEK293_Human1.24884622
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22941238
103MYC_18940864_ChIP-ChIP_HL60_Human1.21807821
104* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20462593
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19782197
106ZNF263_19887448_ChIP-Seq_K562_Human1.19279110
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.18891345
108ERG_21242973_ChIP-ChIP_JURKAT_Human1.18413161
109* AR_25329375_ChIP-Seq_VCAP_Human1.17714456
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17251958
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.17196629
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.16327958
113TAF15_26573619_Chip-Seq_HEK293_Human1.15622712
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15430100
115AHR_22903824_ChIP-Seq_MCF-7_Human1.13903926
116BCAT_22108803_ChIP-Seq_LS180_Human1.13665200
117SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13450289
118YY1_21170310_ChIP-Seq_MESCs_Mouse1.11559841
119GATA4_21415370_ChIP-Seq_HL-1_Mouse1.10595729
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09782216
121RXR_22108803_ChIP-Seq_LS180_Human1.09579483
122* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09503462
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08858647
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08644344
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08582465
126* AR_19668381_ChIP-Seq_PC3_Human1.08580843
127SMAD4_21741376_ChIP-Seq_HESCs_Human1.08215158
128* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08038129
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08030543
130REST_19997604_ChIP-ChIP_NEURONS_Mouse1.07830724
131P300_19829295_ChIP-Seq_ESCs_Human1.07673088
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07573485
133SMAD3_21741376_ChIP-Seq_HESCs_Human1.06554579
134* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06239870
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04728446
136FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04125523
137EWS_26573619_Chip-Seq_HEK293_Human1.03700894
138IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03480192
139YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03456350
140SALL1_21062744_ChIP-ChIP_HESCs_Human1.03074790
141EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02822687
142* VDR_23849224_ChIP-Seq_CD4+_Human1.02116494
143CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01758701
144EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01168852
145ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01086424
146CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00695726
147DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00460931
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99838096
149NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99838096
150TP53_18474530_ChIP-ChIP_U2OS_Human0.99031906
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98869168
152TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98768397
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98364795
154* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97670440
155VDR_22108803_ChIP-Seq_LS180_Human0.97632628
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97535678
157GATA1_26923725_Chip-Seq_HPCs_Mouse0.97317302
158* STAT3_23295773_ChIP-Seq_U87_Human0.97051892
159GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96409245
160* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96000251
161HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95852160
162TP53_16413492_ChIP-PET_HCT116_Human0.94757961
163* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94685139
164KDM2B_26808549_Chip-Seq_K562_Human0.94454873
165NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94407861
166FOXP3_21729870_ChIP-Seq_TREG_Human0.93286485
167PRDM14_20953172_ChIP-Seq_ESCs_Human0.93169774
168UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92709705
169* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92158611
170ER_23166858_ChIP-Seq_MCF-7_Human0.91783690
171ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91493990
172ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91420828
173WT1_19549856_ChIP-ChIP_CCG9911_Human0.91184099
174* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91051674
175RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90705533
176KDM5A_27292631_Chip-Seq_BREAST_Human0.89940480
177NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89268933
178MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88042696
179SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85829504
180RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85639210
181DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85408783
182GABP_19822575_ChIP-Seq_HepG2_Human0.84786299
183CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81512657
184NANOG_21062744_ChIP-ChIP_HESCs_Human0.80713941
185CIITA_25753668_ChIP-Seq_RAJI_Human0.79645126
186CLOCK_20551151_ChIP-Seq_293T_Human0.78841808
187SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78827526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.31117442
2MP0004859_abnormal_synaptic_plasticity3.92325053
3MP0000751_myopathy3.87313228
4MP0003646_muscle_fatigue3.63168458
5MP0004215_abnormal_myocardial_fiber3.28592532
6MP0004084_abnormal_cardiac_muscle3.10934448
7MP0001188_hyperpigmentation2.89883493
8MP0010094_abnormal_chromosome_stability2.88713706
9MP0008057_abnormal_DNA_replication2.62093045
10MP0004043_abnormal_pH_regulation2.59713531
11MP0009379_abnormal_foot_pigmentation2.55912971
12MP0004036_abnormal_muscle_relaxation2.48101525
13MP0003635_abnormal_synaptic_transmissio2.47374890
14MP0004130_abnormal_muscle_cell2.42522473
15MP0002009_preneoplasia2.38493361
16MP0004270_analgesia2.27937563
17MP0004484_altered_response_of2.27458602
18MP0008058_abnormal_DNA_repair2.25794029
19MP0003880_abnormal_central_pattern2.24804497
20MP0005330_cardiomyopathy2.18199285
21MP0000749_muscle_degeneration2.14882876
22MP0002877_abnormal_melanocyte_morpholog2.13210140
23MP0002972_abnormal_cardiac_muscle2.11903449
24MP0005620_abnormal_muscle_contractility2.00922219
25MP0009780_abnormal_chondrocyte_physiolo1.96917748
26MP0009046_muscle_twitch1.93619795
27MP0002063_abnormal_learning/memory/cond1.93540928
28MP0009745_abnormal_behavioral_response1.93093036
29MP0003137_abnormal_impulse_conducting1.92048518
30MP0004087_abnormal_muscle_fiber1.90914562
31MP0003693_abnormal_embryo_hatching1.86454745
32MP0003077_abnormal_cell_cycle1.84379894
33MP0004957_abnormal_blastocyst_morpholog1.84314130
34MP0003111_abnormal_nucleus_morphology1.84087268
35MP0002064_seizures1.81758026
36MP0008775_abnormal_heart_ventricle1.81749176
37MP0004145_abnormal_muscle_electrophysio1.80918019
38MP0004233_abnormal_muscle_weight1.77378711
39MP0000747_muscle_weakness1.73523205
40MP0002734_abnormal_mechanical_nocicepti1.58161058
41MP0003329_amyloid_beta_deposits1.55531909
42MP0004085_abnormal_heartbeat1.54203531
43MP0001968_abnormal_touch/_nociception1.50133772
44MP0004858_abnormal_nervous_system1.49445598
45MP0002909_abnormal_adrenal_gland1.48524392
46MP0004885_abnormal_endolymph1.48523354
47MP0002106_abnormal_muscle_physiology1.48160006
48MP0001440_abnormal_grooming_behavior1.47088477
49MP0005385_cardiovascular_system_phenoty1.43036183
50MP0001544_abnormal_cardiovascular_syste1.43036183
51MP0002572_abnormal_emotion/affect_behav1.42420874
52MP0006138_congestive_heart_failure1.41317594
53MP0005386_behavior/neurological_phenoty1.38897719
54MP0004924_abnormal_behavior1.38897719
55MP0003221_abnormal_cardiomyocyte_apopto1.37631971
56MP0002272_abnormal_nervous_system1.36246231
57MP0001529_abnormal_vocalization1.35141063
58MP0002735_abnormal_chemical_nociception1.34517978
59MP0000750_abnormal_muscle_regeneration1.32860171
60MP0000013_abnormal_adipose_tissue1.32139001
61MP0001486_abnormal_startle_reflex1.32112548
62MP0002067_abnormal_sensory_capabilities1.30651855
63MP0005409_darkened_coat_color1.29339277
64MP0005369_muscle_phenotype1.25786212
65MP0000778_abnormal_nervous_system1.25604726
66MP0006276_abnormal_autonomic_nervous1.25418707
67MP0000759_abnormal_skeletal_muscle1.25262878
68MP0002269_muscular_atrophy1.24726287
69MP0008569_lethality_at_weaning1.24071378
70MP0008932_abnormal_embryonic_tissue1.23733251
71MP0005666_abnormal_adipose_tissue1.23660194
72MP0001765_abnormal_ion_homeostasis1.22472604
73MP0008961_abnormal_basal_metabolism1.21177215
74MP0005623_abnormal_meninges_morphology1.20925559
75MP0002736_abnormal_nociception_after1.18099081
76MP0001958_emphysema1.17458379
77MP0010630_abnormal_cardiac_muscle1.16580847
78MP0005645_abnormal_hypothalamus_physiol1.16088681
79MP0001661_extended_life_span1.14302398
80MP0005423_abnormal_somatic_nervous1.10833890
81MP0002733_abnormal_thermal_nociception1.10069401
82MP0001970_abnormal_pain_threshold1.08008308
83MP0001348_abnormal_lacrimal_gland1.04900222
84MP0000579_abnormal_nail_morphology1.03900119
85MP0000569_abnormal_digit_pigmentation1.02933946
86MP0004185_abnormal_adipocyte_glucose1.02137139
87MP0004510_myositis1.02103046
88MP0004811_abnormal_neuron_physiology1.00327799
89MP0005535_abnormal_body_temperature0.99640279
90MP0001177_atelectasis0.98961053
91MP0008007_abnormal_cellular_replicative0.98757773
92MP0000015_abnormal_ear_pigmentation0.98176950
93MP0006036_abnormal_mitochondrial_physio0.97215148
94MP0002066_abnormal_motor_capabilities/c0.97040073
95MP0002638_abnormal_pupillary_reflex0.95170332
96MP0002822_catalepsy0.95167561
97MP0005375_adipose_tissue_phenotype0.94503553
98MP0003633_abnormal_nervous_system0.93610894
99MP0006072_abnormal_retinal_apoptosis0.93454285
100MP0002184_abnormal_innervation0.93410051
101MP0000230_abnormal_systemic_arterial0.93298202
102MP0002234_abnormal_pharynx_morphology0.91143374
103MP0001501_abnormal_sleep_pattern0.89741871
104MP0002557_abnormal_social/conspecific_i0.89149339
105MP0005171_absent_coat_pigmentation0.88048896
106MP0000350_abnormal_cell_proliferation0.87836218
107MP0001984_abnormal_olfaction0.87368637
108MP0010234_abnormal_vibrissa_follicle0.86956600
109MP0005380_embryogenesis_phenotype0.86791222
110MP0001672_abnormal_embryogenesis/_devel0.86791222
111MP0008877_abnormal_DNA_methylation0.86641020
112MP0010352_gastrointestinal_tract_polyps0.86387727
113MP0003984_embryonic_growth_retardation0.86214816
114MP0001756_abnormal_urination0.85727237
115MP0001299_abnormal_eye_distance/0.85257896
116MP0005670_abnormal_white_adipose0.85055271
117MP0002088_abnormal_embryonic_growth/wei0.82198660
118MP0003786_premature_aging0.82161199
119MP0002090_abnormal_vision0.82137432
120MP0000955_abnormal_spinal_cord0.81168729
121MP0003634_abnormal_glial_cell0.80475910
122MP0000003_abnormal_adipose_tissue0.80246714
123MP0002080_prenatal_lethality0.79995172
124MP0002166_altered_tumor_susceptibility0.78186138
125MP0002882_abnormal_neuron_morphology0.78062971
126MP0005187_abnormal_penis_morphology0.76552162
127MP0001730_embryonic_growth_arrest0.76358657
128MP0001697_abnormal_embryo_size0.74629527
129MP0005377_hearing/vestibular/ear_phenot0.73938794
130MP0003878_abnormal_ear_physiology0.73938794
131MP0002108_abnormal_muscle_morphology0.73524944
132MP0002332_abnormal_exercise_endurance0.72314355
133MP0003879_abnormal_hair_cell0.72033993
134MP0004147_increased_porphyrin_level0.71964839
135MP0003567_abnormal_fetal_cardiomyocyte0.70968461
136MP0005165_increased_susceptibility_to0.70621647
137MP0003828_pulmonary_edema0.69209096
138MP0003283_abnormal_digestive_organ0.67181885
139MP0005332_abnormal_amino_acid0.67104491
140MP0000372_irregular_coat_pigmentation0.66588871
141MP0006035_abnormal_mitochondrial_morpho0.66313248

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.81721313
2Exercise-induced myalgia (HP:0003738)4.02002489
3Abnormality of glycolysis (HP:0004366)3.91732583
4Increased circulating renin level (HP:0000848)3.87185642
5Exercise-induced muscle cramps (HP:0003710)3.74581944
6Calf muscle hypertrophy (HP:0008981)3.72500914
7Metabolic alkalosis (HP:0200114)3.67753513
8Abnormality of the calf musculature (HP:0001430)3.56030309
9Muscle hypertrophy of the lower extremities (HP:0008968)3.55784154
10Atrial fibrillation (HP:0005110)3.52641841
11Ragged-red muscle fibers (HP:0003200)3.48412564
12Increased serum pyruvate (HP:0003542)3.47655473
13Primary atrial arrhythmia (HP:0001692)3.39078673
14Hypokalemic alkalosis (HP:0001949)3.30424933
15Focal motor seizures (HP:0011153)3.28706989
16Supraventricular tachycardia (HP:0004755)3.21317202
17Muscle fiber splitting (HP:0003555)3.21202016
18Visual hallucinations (HP:0002367)3.18547307
19Myoglobinuria (HP:0002913)3.16082846
20Supraventricular arrhythmia (HP:0005115)3.14225378
21Syncope (HP:0001279)3.12849166
22Bundle branch block (HP:0011710)3.08079002
23Ventricular tachycardia (HP:0004756)3.04724857
24Pheochromocytoma (HP:0002666)3.04525327
25Prolonged QT interval (HP:0001657)2.96210137
26Polyuria (HP:0000103)2.95039016
27Ventricular fibrillation (HP:0001663)2.91433638
28Hypomagnesemia (HP:0002917)2.84652240
29Hyperactive renin-angiotensin system (HP:0000841)2.84260718
30Hyporeflexia of lower limbs (HP:0002600)2.81435139
31Myokymia (HP:0002411)2.80681555
32Difficulty running (HP:0009046)2.78635372
33Gout (HP:0001997)2.77055826
34Abnormal urine output (HP:0012590)2.72248573
35Abnormality of chloride homeostasis (HP:0011422)2.68394904
36Neuroendocrine neoplasm (HP:0100634)2.65537327
37Polydipsia (HP:0001959)2.64815822
38Abnormal drinking behavior (HP:0030082)2.64815822
39Conjunctival hamartoma (HP:0100780)2.62989364
40Focal seizures (HP:0007359)2.59227696
41Lipoatrophy (HP:0100578)2.54123644
42Myotonia (HP:0002486)2.52410839
43EMG: myopathic abnormalities (HP:0003458)2.51780793
44Atrioventricular block (HP:0001678)2.51074952
45Abnormality of renal excretion (HP:0011036)2.46272056
46Autoamputation (HP:0001218)2.44210131
47Ventricular arrhythmia (HP:0004308)2.43790468
48Hamartoma of the eye (HP:0010568)2.42726991
49Abnormality of magnesium homeostasis (HP:0004921)2.41687697
50Tetraplegia (HP:0002445)2.39793379
51Volvulus (HP:0002580)2.38229100
52Increased variability in muscle fiber diameter (HP:0003557)2.37540870
53Cortical dysplasia (HP:0002539)2.36337168
54Hyperaldosteronism (HP:0000859)2.35839408
55Asymmetric septal hypertrophy (HP:0001670)2.33863584
56Abnormal EKG (HP:0003115)2.30806146
57Abnormality of DNA repair (HP:0003254)2.30628137
58Abnormality of renin-angiotensin system (HP:0000847)2.29594329
59Palpitations (HP:0001962)2.29267833
60Chromsome breakage (HP:0040012)2.23919107
61Microvesicular hepatic steatosis (HP:0001414)2.23073882
62* Ketoacidosis (HP:0001993)2.21759560
63Increased purine levels (HP:0004368)2.20823422
64Hyperuricemia (HP:0002149)2.20823422
65Abnormal mitochondria in muscle tissue (HP:0008316)2.19932280
66Limb-girdle muscle atrophy (HP:0003797)2.19377034
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18987932
68Right ventricular cardiomyopathy (HP:0011663)2.16454071
69Epileptic encephalopathy (HP:0200134)2.14836740
70Increased connective tissue (HP:0009025)2.13302079
71Hyperventilation (HP:0002883)2.13300390
72Increased nuchal translucency (HP:0010880)2.12511666
73Broad-based gait (HP:0002136)2.11943631
74Dilated cardiomyopathy (HP:0001644)2.11655612
75Athetosis (HP:0002305)2.11625945
76Cerebral hypomyelination (HP:0006808)2.11379178
77Dysmetric saccades (HP:0000641)2.08837880
78Lymphangioma (HP:0100764)2.08832876
79Abnormal eating behavior (HP:0100738)2.08699643
80Neoplasm of the peripheral nervous system (HP:0100007)2.07419798
81Poor eye contact (HP:0000817)2.07189119
82Abnormality of the left ventricular outflow tract (HP:0011103)2.06398190
83Subaortic stenosis (HP:0001682)2.06398190
84Heterochromia iridis (HP:0001100)2.06303513
85Acute necrotizing encephalopathy (HP:0006965)2.05383131
86Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.05250770
87Abnormality of the foot musculature (HP:0001436)2.04318441
88Rhabdomyolysis (HP:0003201)2.03691695
89Horizontal nystagmus (HP:0000666)2.02354555
90Central scotoma (HP:0000603)2.01703983
91Cutaneous melanoma (HP:0012056)2.01581391
92Insomnia (HP:0100785)2.01514271
93Impaired pain sensation (HP:0007328)2.00985143
94Abnormality of pain sensation (HP:0010832)2.00985143
95Abnormal social behavior (HP:0012433)2.00718043
96Impaired social interactions (HP:0000735)2.00718043
97Heart block (HP:0012722)2.00133334
98Abnormality of skeletal muscle fiber size (HP:0012084)1.99730189
99Impaired vibration sensation in the lower limbs (HP:0002166)1.99394893
100Abnormality of alanine metabolism (HP:0010916)1.98929151
101Hyperalaninemia (HP:0003348)1.98929151
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98929151
103Progressive macrocephaly (HP:0004481)1.98268472
104Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97432795
105Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97432795
106Hypokalemia (HP:0002900)1.95851939
107Acute encephalopathy (HP:0006846)1.94658252
108Neoplasm of the adrenal gland (HP:0100631)1.94180219
109Papilledema (HP:0001085)1.93655995
110Action tremor (HP:0002345)1.93518158
111Termporal pattern (HP:0011008)1.92492270
112Insidious onset (HP:0003587)1.92492270
113Rapidly progressive (HP:0003678)1.91898555
114Progressive muscle weakness (HP:0003323)1.91194753
115Urinary urgency (HP:0000012)1.89234957
116Mutism (HP:0002300)1.88973955
117Abnormal atrioventricular conduction (HP:0005150)1.88547315
118Abnormal auditory evoked potentials (HP:0006958)1.88051958
119Epileptiform EEG discharges (HP:0011182)1.87897507
120Anxiety (HP:0000739)1.86965943
121Generalized tonic-clonic seizures (HP:0002069)1.86863681
122Postnatal microcephaly (HP:0005484)1.86722427
123Absence seizures (HP:0002121)1.86593228
124Atonic seizures (HP:0010819)1.85244825
125Spastic gait (HP:0002064)1.84213845
126Cerebral inclusion bodies (HP:0100314)1.83823924
127Tetany (HP:0001281)1.83626910
128Supranuclear gaze palsy (HP:0000605)1.83583260
129Difficulty climbing stairs (HP:0003551)1.83571000
130Increased intramyocellular lipid droplets (HP:0012240)1.83532546
131Progressive external ophthalmoplegia (HP:0000590)1.83232673
132Proximal tubulopathy (HP:0000114)1.82964567
133Left ventricular hypertrophy (HP:0001712)1.82593325
134Abnormality of the vocal cords (HP:0008777)1.81886196
135Progressive inability to walk (HP:0002505)1.81692110
136Astrocytoma (HP:0009592)1.79092999
137Abnormality of the astrocytes (HP:0100707)1.79092999
138Foot dorsiflexor weakness (HP:0009027)1.78895982
139Relative macrocephaly (HP:0004482)1.77895960
140EEG with generalized epileptiform discharges (HP:0011198)1.77681173
141Febrile seizures (HP:0002373)1.76914721
142Ankyloglossia (HP:0010296)1.76723773
143CNS hypomyelination (HP:0003429)1.75856024
144Hypsarrhythmia (HP:0002521)1.75404935
145Abnormality of the corticospinal tract (HP:0002492)1.73149949
146Calcaneovalgus deformity (HP:0001848)1.72922947
147Scanning speech (HP:0002168)1.72600163
148Dysdiadochokinesis (HP:0002075)1.70857363
149Resting tremor (HP:0002322)1.70601633
150Failure to thrive in infancy (HP:0001531)1.67704380
151Sparse lateral eyebrow (HP:0005338)1.65402275
152EMG: neuropathic changes (HP:0003445)1.65233293
153Cerebral edema (HP:0002181)1.64457926
154Abnormal gallbladder physiology (HP:0012438)1.63943556
155Cholecystitis (HP:0001082)1.63943556
156Limb hypertonia (HP:0002509)1.63922792
157Ankle clonus (HP:0011448)1.63214758
158Hypoglycemic coma (HP:0001325)1.63020298
159Megaloblastic anemia (HP:0001889)1.62942637
160Sacral dimple (HP:0000960)1.62871102
161Abnormality of the anterior horn cell (HP:0006802)1.62403700
162Degeneration of anterior horn cells (HP:0002398)1.62403700
163Testicular atrophy (HP:0000029)1.62222776
164Abnormality of cochlea (HP:0000375)1.62098330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.24952885
2WNK43.24462529
3PHKG13.10269944
4PHKG23.10269944
5LMTK22.87681159
6CDC72.83866807
7PDK42.72431504
8PDK32.72431504
9OXSR12.68610403
10TTN2.68520498
11BUB12.58586760
12WNK32.47681483
13TTK2.34726361
14MAP3K92.29260658
15MAP3K42.20861119
16TRIB32.12713515
17MINK12.04217792
18NTRK32.03767800
19EPHA42.03059683
20EEF2K2.02280228
21STK391.98015506
22NEK11.89387181
23TSSK61.83610156
24PBK1.82768688
25PAK61.78413526
26PKN21.78179880
27DMPK1.74330893
28CCNB11.71004257
29SRPK11.61695640
30PDK21.57901906
31KSR21.54001103
32WEE11.49218176
33OBSCN1.44485075
34BRSK11.42706369
35PAK31.40980607
36MAP2K71.34867847
37ALK1.33360554
38NTRK11.31742275
39CAMKK11.31232865
40EIF2AK11.31163580
41NTRK21.28562015
42MAP2K41.26196664
43MKNK11.25186847
44DAPK21.23599416
45PLK31.22995905
46MYLK1.21192057
47KSR11.18023671
48LATS21.12166044
49MAPKAPK51.09654384
50WNK11.08982882
51RPS6KB21.08068311
52CAMKK21.07513516
53STK381.06349790
54EIF2AK31.03407863
55CDK51.02224426
56PRKD31.01481224
57PLK21.00380020
58NEK91.00311451
59SCYL20.99772911
60PINK10.99066498
61CLK10.99006016
62PIK3CA0.94782546
63BRSK20.94487249
64PLK10.93942717
65AURKB0.92701224
66RIPK10.91377120
67RET0.90139642
68CDK11A0.89896277
69CHEK20.89144269
70BMPR20.88973616
71ATR0.87271726
72AURKA0.86809100
73SGK4940.85640675
74SGK2230.85640675
75BCR0.84710992
76PLK40.83553604
77BRAF0.79717257
78CAMK2A0.79100281
79MST1R0.76718383
80MAP3K60.76297058
81RIPK40.75415093
82MAPK120.74808111
83GRK50.73747843
84MAPK100.73065478
85CHEK10.72626316
86NEK60.71460603
87MAPK130.69939357
88DDR20.69926199
89CAMK2D0.69788697
90FER0.69370174
91AKT20.68771331
92PDGFRA0.68375510
93PDPK10.67997916
94PNCK0.67825820
95MAP3K20.66951590
96ROCK10.66583518
97GRK70.66583198
98PTK2B0.66480023
99PRKCH0.65470550
100BCKDK0.65186287
101ILK0.63964658
102PDK10.63468028
103MAP3K120.63433106
104AKT30.63251511
105NEK20.62860392
106PRKCE0.62722032
107CDK60.62591274
108PRKDC0.62251434
109SGK10.62065803
110MAP3K70.61617695
111ATM0.61348949
112STK40.61213632
113STK110.60522153
114CDK10.59947832
115SGK30.59502380
116CAMK1G0.59059659
117CSNK1E0.58937956
118ROCK20.58897485
119CASK0.58384924
120PRKCG0.57314066
121CDK20.56804389
122RAF10.56029776
123PRKD10.55651148
124CSNK1G20.55125089
125ARAF0.54366863
126NME10.54005198
127SGK20.53797430
128PRKAA10.53712561
129SMG10.53515620
130CDK190.52597198
131PRPF4B0.51489451
132SIK20.51251609
133UHMK10.51005194
134CAMK10.50821524
135CSNK1G30.50565806
136PKN10.49620228
137LIMK10.49560631
138CDK140.49558337
139CSNK1A1L0.49094740
140MAP3K130.48687678
141ZAK0.48672296
142ERBB30.48314909
143STK38L0.47123461
144TIE10.46697087
145RPS6KA30.46070924
146STK240.44365798
147TNIK0.43651808
148CDK150.42609975
149DAPK10.41873275
150CDK180.41838339
151MAP2K10.41137984
152TAOK10.40348231
153TYRO30.39881153
154FGFR20.37810385
155CAMK2B0.37421573
156FRK0.36363920
157DAPK30.36159580

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.80200742
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.95413768
3DNA replication_Homo sapiens_hsa030302.84235270
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.52482614
5Cardiac muscle contraction_Homo sapiens_hsa042602.46395774
6Mismatch repair_Homo sapiens_hsa034302.26672608
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24784287
8Synaptic vesicle cycle_Homo sapiens_hsa047211.99398453
9Propanoate metabolism_Homo sapiens_hsa006401.95802663
10Non-homologous end-joining_Homo sapiens_hsa034501.94265092
11Oxidative phosphorylation_Homo sapiens_hsa001901.93526191
12Nucleotide excision repair_Homo sapiens_hsa034201.90612186
13Dilated cardiomyopathy_Homo sapiens_hsa054141.86557115
14Gastric acid secretion_Homo sapiens_hsa049711.81334895
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79721291
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.79699071
17Biosynthesis of amino acids_Homo sapiens_hsa012301.79476609
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76914660
19Parkinsons disease_Homo sapiens_hsa050121.75887467
20Cell cycle_Homo sapiens_hsa041101.74592767
21Nicotine addiction_Homo sapiens_hsa050331.74011673
22Collecting duct acid secretion_Homo sapiens_hsa049661.72887595
23RNA transport_Homo sapiens_hsa030131.71916564
24Circadian entrainment_Homo sapiens_hsa047131.67127493
25Oocyte meiosis_Homo sapiens_hsa041141.66148119
26Long-term potentiation_Homo sapiens_hsa047201.65803570
27Alzheimers disease_Homo sapiens_hsa050101.61591559
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.59468715
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56752340
30GABAergic synapse_Homo sapiens_hsa047271.56216897
31Renin secretion_Homo sapiens_hsa049241.50229069
32Olfactory transduction_Homo sapiens_hsa047401.47276904
33Salivary secretion_Homo sapiens_hsa049701.45756102
34Morphine addiction_Homo sapiens_hsa050321.43962798
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42512594
36Fanconi anemia pathway_Homo sapiens_hsa034601.42225463
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41830931
38Glutamatergic synapse_Homo sapiens_hsa047241.38531136
39Dopaminergic synapse_Homo sapiens_hsa047281.33401505
40Oxytocin signaling pathway_Homo sapiens_hsa049211.33265439
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30666736
42Cholinergic synapse_Homo sapiens_hsa047251.28127908
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25828888
44Amphetamine addiction_Homo sapiens_hsa050311.24420961
45mRNA surveillance pathway_Homo sapiens_hsa030151.23923553
46Insulin secretion_Homo sapiens_hsa049111.23323391
47* Butanoate metabolism_Homo sapiens_hsa006501.21751034
48One carbon pool by folate_Homo sapiens_hsa006701.17336942
49Pyruvate metabolism_Homo sapiens_hsa006201.16791444
50Base excision repair_Homo sapiens_hsa034101.15750924
51Carbon metabolism_Homo sapiens_hsa012001.14810374
52Calcium signaling pathway_Homo sapiens_hsa040201.14447989
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11442062
54Fatty acid metabolism_Homo sapiens_hsa012121.11165872
55Proteasome_Homo sapiens_hsa030501.10678440
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10431082
57Gap junction_Homo sapiens_hsa045401.08732291
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07305142
59Spliceosome_Homo sapiens_hsa030401.07060996
60Pentose phosphate pathway_Homo sapiens_hsa000301.04044989
61Fatty acid degradation_Homo sapiens_hsa000711.03561557
62Huntingtons disease_Homo sapiens_hsa050161.02362813
63* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99940908
64Taste transduction_Homo sapiens_hsa047420.98913209
65Long-term depression_Homo sapiens_hsa047300.97859534
66GnRH signaling pathway_Homo sapiens_hsa049120.95626015
67Alcoholism_Homo sapiens_hsa050340.95143972
68cAMP signaling pathway_Homo sapiens_hsa040240.94421465
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94052437
70Fatty acid elongation_Homo sapiens_hsa000620.94024570
71Arginine biosynthesis_Homo sapiens_hsa002200.93365869
72Glioma_Homo sapiens_hsa052140.92380676
73Type II diabetes mellitus_Homo sapiens_hsa049300.91782424
74Serotonergic synapse_Homo sapiens_hsa047260.90062971
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86252416
76Vibrio cholerae infection_Homo sapiens_hsa051100.85069735
77Estrogen signaling pathway_Homo sapiens_hsa049150.84626475
78Axon guidance_Homo sapiens_hsa043600.83259177
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81762779
80RNA degradation_Homo sapiens_hsa030180.80942800
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.79765754
82Glucagon signaling pathway_Homo sapiens_hsa049220.75987611
83* Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75767501
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.74759513
85Homologous recombination_Homo sapiens_hsa034400.74622757
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73990412
87Insulin signaling pathway_Homo sapiens_hsa049100.73917338
88Purine metabolism_Homo sapiens_hsa002300.73561501
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73496565
90Arginine and proline metabolism_Homo sapiens_hsa003300.73405943
91Cocaine addiction_Homo sapiens_hsa050300.73331744
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72305654
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70607712
94Melanogenesis_Homo sapiens_hsa049160.70409319
95Vitamin B6 metabolism_Homo sapiens_hsa007500.69516770
96Phenylalanine metabolism_Homo sapiens_hsa003600.67545413
97Thyroid hormone synthesis_Homo sapiens_hsa049180.66984305
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66902500
99Pancreatic secretion_Homo sapiens_hsa049720.64912124
100Viral myocarditis_Homo sapiens_hsa054160.63908198
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.62433192
102ErbB signaling pathway_Homo sapiens_hsa040120.61825713
103Renal cell carcinoma_Homo sapiens_hsa052110.60968638
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60329637
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.59735135
106AMPK signaling pathway_Homo sapiens_hsa041520.59589513
107Focal adhesion_Homo sapiens_hsa045100.59339079
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58919467
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58149335
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57191621
111Choline metabolism in cancer_Homo sapiens_hsa052310.56470062
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56166011
113VEGF signaling pathway_Homo sapiens_hsa043700.55164323
114Fatty acid biosynthesis_Homo sapiens_hsa000610.54605183
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54285533
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53770044
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53372041
118Insulin resistance_Homo sapiens_hsa049310.53338753
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.53330118
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52469299
121Dorso-ventral axis formation_Homo sapiens_hsa043200.52390000
122Endometrial cancer_Homo sapiens_hsa052130.48826062
123Protein digestion and absorption_Homo sapiens_hsa049740.48801578
124mTOR signaling pathway_Homo sapiens_hsa041500.47870738
125Bile secretion_Homo sapiens_hsa049760.46789863
126Tight junction_Homo sapiens_hsa045300.46578180
127beta-Alanine metabolism_Homo sapiens_hsa004100.46496052
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45627903
129Pyrimidine metabolism_Homo sapiens_hsa002400.44701187
130Mineral absorption_Homo sapiens_hsa049780.43839087
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43063685
132Protein export_Homo sapiens_hsa030600.42820294
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42367595
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40868584
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.40753564
136Rap1 signaling pathway_Homo sapiens_hsa040150.40651063
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.40106490
138Circadian rhythm_Homo sapiens_hsa047100.39283156
139PPAR signaling pathway_Homo sapiens_hsa033200.37929134
140N-Glycan biosynthesis_Homo sapiens_hsa005100.34387585

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