ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	9.12990425
2	chromosome condensation (GO:0030261)	8.88833943
3	sperm capacitation (GO:0048240)	8.43073398
4	DNA packaging (GO:0006323)	8.23213495
5	plasma membrane fusion (GO:0045026)	7.81502845
6	microtubule depolymerization (GO:0007019)	7.29656971
7	sperm-egg recognition (GO:0035036)	6.94749757
8	cellular ketone body metabolic process (GO:0046950)	6.93419950
9	negative regulation of inclusion body assembly (GO:0090084)	6.92361970
10	spermatid nucleus differentiation (GO:0007289)	6.83111042
11	binding of sperm to zona pellucida (GO:0007339)	6.82108386
12	spermatid development (GO:0007286)	6.76278015
13	sexual reproduction (GO:0019953)	6.42158089
14	single strand break repair (GO:0000012)	6.39463730
15	response to pheromone (GO:0019236)	6.35840235
16	rRNA methylation (GO:0031167)	6.35823322
17	multicellular organism reproduction (GO:0032504)	6.28029391
18	ketone body metabolic process (GO:1902224)	6.08686780
19	reproduction (GO:0000003)	6.08384278
20	cell-cell recognition (GO:0009988)	5.58114798
21	microtubule severing (GO:0051013)	5.56452426
22	calcium ion-dependent exocytosis (GO:0017156)	5.38505407
23	rRNA modification (GO:0000154)	5.23890017
24	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.02338268
25	microtubule polymerization or depolymerization (GO:0031109)	4.99865178
26	spermatogenesis (GO:0007283)	4.71925880
27	male gamete generation (GO:0048232)	4.69703405
28	regulation of inclusion body assembly (GO:0090083)	4.61600297
29	phosphatidylethanolamine metabolic process (GO:0046337)	4.44852943
30	protein polyglutamylation (GO:0018095)	4.40804533
31	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	4.38898050
32	kidney mesenchyme development (GO:0072074)	4.36270654
33	metanephric mesenchyme development (GO:0072075)	4.31064571
34	gamete generation (GO:0007276)	4.27131740
35	single fertilization (GO:0007338)	4.12065254
36	peptidyl-proline hydroxylation (GO:0019511)	4.00549639
37	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.85224332
38	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.85224332
39	chromatin silencing (GO:0006342)	3.79071050
40	glomerular visceral epithelial cell development (GO:0072015)	3.74617129
41	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.70192197
42	cellular response to pH (GO:0071467)	3.68597422
43	outer ear morphogenesis (GO:0042473)	3.67267076
44	germ cell development (GO:0007281)	3.66885192
45	tooth mineralization (GO:0034505)	3.64430409
46	membrane protein intracellular domain proteolysis (GO:0031293)	3.63674159
47	response to acidic pH (GO:0010447)	3.60573642
48	positive regulation of Rab GTPase activity (GO:0032851)	3.58430407
49	regulation of Rab GTPase activity (GO:0032313)	3.58430407
50	coenzyme catabolic process (GO:0009109)	3.55007266
51	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.54866144
52	multicellular organismal reproductive process (GO:0048609)	3.53553516
53	regulation of transcription involved in cell fate commitment (GO:0060850)	3.47746712
54	glomerular epithelial cell development (GO:0072310)	3.47550573
55	protein targeting to Golgi (GO:0000042)	3.41684899
56	nucleus organization (GO:0006997)	3.36331851
57	axonemal dynein complex assembly (GO:0070286)	3.32817987
58	hyaluronan catabolic process (GO:0030214)	3.30215441
59	glycerol ether metabolic process (GO:0006662)	3.27820351
60	negative regulation of Rho protein signal transduction (GO:0035024)	3.25137148
61	cell proliferation involved in metanephros development (GO:0072203)	3.22373434
62	homeostasis of number of cells within a tissue (GO:0048873)	3.22243901
63	membrane protein ectodomain proteolysis (GO:0006509)	3.22134916
64	cell differentiation involved in metanephros development (GO:0072202)	3.21609312
65	protein depolymerization (GO:0051261)	3.19927013
66	protein-DNA complex disassembly (GO:0032986)	3.19894121
67	nucleosome disassembly (GO:0006337)	3.19894121
68	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.13458640
69	mitotic G1 DNA damage checkpoint (GO:0031571)	3.12664649
70	protein retention in ER lumen (GO:0006621)	3.12436712
71	protein hydroxylation (GO:0018126)	3.12098708
72	chaperone-mediated protein complex assembly (GO:0051131)	3.11302110
73	cochlea morphogenesis (GO:0090103)	3.07325272
74	embryonic skeletal joint morphogenesis (GO:0060272)	3.07155333
75	cell volume homeostasis (GO:0006884)	3.06621577
76	establishment of protein localization to Golgi (GO:0072600)	3.05802527
77	fertilization (GO:0009566)	3.05491775
78	4-hydroxyproline metabolic process (GO:0019471)	3.04795695
79	cell wall macromolecule catabolic process (GO:0016998)	3.04690795
80	positive regulation of endothelial cell differentiation (GO:0045603)	3.02866082
81	pattern specification involved in kidney development (GO:0061004)	2.98449851
82	ether metabolic process (GO:0018904)	2.95650551
83	motile cilium assembly (GO:0044458)	2.94442933
84	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.94176965
85	regulation of protein polyubiquitination (GO:1902914)	2.90699402
86	multicellular organismal movement (GO:0050879)	2.89151003
87	musculoskeletal movement (GO:0050881)	2.89151003
88	actin filament capping (GO:0051693)	2.87101096
89	polyamine biosynthetic process (GO:0006596)	2.86547536
90	cell migration involved in heart development (GO:0060973)	2.82690200
91	peptidyl-threonine dephosphorylation (GO:0035970)	2.81360571
92	positive regulation of myotube differentiation (GO:0010831)	2.81354927
93	regulation of T-helper 2 cell differentiation (GO:0045628)	2.81276791
94	DNA conformation change (GO:0071103)	2.80286859
95	mitotic G1/S transition checkpoint (GO:0044819)	2.80244580
96	establishment of apical/basal cell polarity (GO:0035089)	2.77158000
97	regulation of cilium movement (GO:0003352)	2.72731473
98	positive regulation of macrophage activation (GO:0043032)	2.72482384
99	acrosome reaction (GO:0007340)	10.5258581
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.3208347

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.53984352
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	4.49730942
3	LXR_22292898_ChIP-Seq_THP-1_Human	3.09014178
4	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.95893781
5	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.64002920
6	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.55429191
7	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.41624874
8	CTCF_27219007_Chip-Seq_Bcells_Human	2.34187642
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.22800305
10	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	2.11167572
11	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	2.07688030
12	SMC4_20622854_ChIP-Seq_HELA_Human	1.92612491
13	P68_20966046_ChIP-Seq_HELA_Human	1.85173500
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.83793517
15	TP63_22573176_ChIP-Seq_HFKS_Human	1.80274009
16	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.78235400
17	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.76301847
18	E2F1_20622854_ChIP-Seq_HELA_Human	1.74279720
19	BCOR_27268052_Chip-Seq_Bcells_Human	1.73662410
20	BCL6_27268052_Chip-Seq_Bcells_Human	1.70015445
21	TP53_22127205_ChIP-Seq_IMR90_Human	1.68522659
22	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.68101282
23	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.62401419
24	TP53_18474530_ChIP-ChIP_U2OS_Human	1.59656135
25	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.58699569
26	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.58126877
27	RAC3_21632823_ChIP-Seq_H3396_Human	1.56597815
28	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.55691766
29	CTCF_20526341_ChIP-Seq_ESCs_Human	1.54751459
30	PHF8_20622854_ChIP-Seq_HELA_Human	1.52903459
31	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.52853992
32	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.52701819
33	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.49877485
34	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.48314433
35	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.48187553
36	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.47581928
37	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.47544632
38	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.44549343
39	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.41855160
40	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.41127920
41	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.39844761
42	SA1_27219007_Chip-Seq_Bcells_Human	1.39665691
43	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.39455282
44	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.39449251
45	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.37557253
46	RACK7_27058665_Chip-Seq_MCF-7_Human	1.33102879
47	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.31839351
48	CTCF_21964334_Chip-Seq_Bcells_Human	1.31717127
49	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30495644
50	TP53_23651856_ChIP-Seq_MEFs_Mouse	1.29392865
51	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.28364951
52	DROSHA_22980978_ChIP-Seq_HELA_Human	1.27702922
53	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.27488209
54	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.26868936
55	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.25306175
56	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.22784867
57	P300_27268052_Chip-Seq_Bcells_Human	1.22189105
58	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.21689929
59	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.21349502
60	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.20656042
61	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.20605238
62	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.17698700
63	ERA_21632823_ChIP-Seq_H3396_Human	1.17638750
64	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.17455521
65	ATF3_27146783_Chip-Seq_COLON_Human	1.17120863
66	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.15039188
67	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.14873606
68	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14263797
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12631513
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12631513
71	KDM2B_26808549_Chip-Seq_DND41_Human	1.12565448
72	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.11329752
73	CJUN_26792858_Chip-Seq_BT549_Human	1.10752812
74	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.10160357
75	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.09830834
76	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08001867
77	SOX11_22085726_ChIP-Seq_ESNs_Mouse	1.06994877
78	KDM2B_26808549_Chip-Seq_K562_Human	1.06440744
79	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.04897798
80	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.04808260
81	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.04664682
82	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.02826925
83	GATA1_19941826_ChIP-Seq_K562_Human	1.02441310
84	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.01488744
85	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.00624450
86	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.99976520
87	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.99976368
88	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99164259
89	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.97894800
90	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.97608010
91	OCT4_20526341_ChIP-Seq_ESCs_Human	0.96548871
92	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.96030383
93	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.96008240
94	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.95477573
95	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.94080359
96	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.92446966
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.91490679
98	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.91483813
99	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.91470772
100	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.90727197

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	9.38707533
2	MP0008438_abnormal_cutaneous_collagen	4.31799814
3	MP0005670_abnormal_white_adipose	4.07573592
4	MP0001348_abnormal_lacrimal_gland	3.50132455
5	MP0003705_abnormal_hypodermis_morpholog	3.35543275
6	MP0003878_abnormal_ear_physiology	2.96643098
7	MP0005377_hearing/vestibular/ear_phenot	2.96643098
8	MP0003698_abnormal_male_reproductive	2.90822459
9	MP0004272_abnormal_basement_membrane	2.89737150
10	MP0005623_abnormal_meninges_morphology	2.67740781
11	MP0005503_abnormal_tendon_morphology	2.63747590
12	MP0001929_abnormal_gametogenesis	2.47415331
13	MP0000678_abnormal_parathyroid_gland	2.43718586
14	MP0005257_abnormal_intraocular_pressure	2.31939821
15	MP0004510_myositis	2.21717553
16	MP0003279_aneurysm	2.19531496
17	MP0003091_abnormal_cell_migration	2.04637084
18	MP0009053_abnormal_anal_canal	2.04095417
19	MP0009384_cardiac_valve_regurgitation	1.90865680
20	MP0005275_abnormal_skin_tensile	1.79525287
21	MP0002161_abnormal_fertility/fecundity	1.78567562
22	MP0010368_abnormal_lymphatic_system	1.77422831
23	MP0000534_abnormal_ureter_morphology	1.60076159
24	MP0002138_abnormal_hepatobiliary_system	1.59063378
25	MP0003950_abnormal_plasma_membrane	1.57924891
26	MP0003566_abnormal_cell_adhesion	1.56126159
27	MP0001958_emphysema	1.55406483
28	MP0000003_abnormal_adipose_tissue	1.40927759
29	MP0000049_abnormal_middle_ear	1.35954483
30	MP0001849_ear_inflammation	1.33162832
31	MP0003718_maternal_effect	1.31466892
32	MP0002249_abnormal_larynx_morphology	1.30362560
33	MP0004233_abnormal_muscle_weight	1.29601362
34	MP0005023_abnormal_wound_healing	1.28023813
35	MP0003941_abnormal_skin_development	1.26848216
36	MP0000751_myopathy	1.26740255
37	MP0005595_abnormal_vascular_smooth	1.25588904
38	MP0000767_abnormal_smooth_muscle	1.24588363
39	MP0000733_abnormal_muscle_development	1.21583836
40	MP0001299_abnormal_eye_distance/	1.16272897
41	MP0002132_abnormal_respiratory_system	1.13602700
42	MP0002295_abnormal_pulmonary_circulatio	1.12109711
43	MP0002234_abnormal_pharynx_morphology	1.11055983
44	MP0002060_abnormal_skin_morphology	1.10132913
45	MP0001879_abnormal_lymphatic_vessel	1.07242953
46	MP0002282_abnormal_trachea_morphology	1.05827249
47	MP0002127_abnormal_cardiovascular_syste	0.95533536
48	MP0003011_delayed_dark_adaptation	0.95393470
49	MP0000681_abnormal_thyroid_gland	0.93392524
50	MP0009840_abnormal_foam_cell	0.92369102
51	MP0002254_reproductive_system_inflammat	0.91718034
52	MP0003942_abnormal_urinary_system	0.91324370
53	MP0000013_abnormal_adipose_tissue	0.91308050
54	MP0002108_abnormal_muscle_morphology	0.90324868
55	MP0001542_abnormal_bone_strength	0.87080895
56	MP0003283_abnormal_digestive_organ	0.86984887
57	MP0005508_abnormal_skeleton_morphology	0.86307496
58	MP0000762_abnormal_tongue_morphology	0.86046674
59	MP0002210_abnormal_sex_determination	0.85055765
60	MP0005395_other_phenotype	0.82465011
61	MP0000467_abnormal_esophagus_morphology	0.81836292
62	MP0009250_abnormal_appendicular_skeleto	0.79568719
63	MP0001614_abnormal_blood_vessel	0.78938444
64	MP0001145_abnormal_male_reproductive	0.77814879
65	MP0005375_adipose_tissue_phenotype	0.77585993
66	MP0000163_abnormal_cartilage_morphology	0.77128924
67	MP0005310_abnormal_salivary_gland	0.76055635
68	MP0004084_abnormal_cardiac_muscle	0.71453374
69	MP0002896_abnormal_bone_mineralization	0.71256401
70	MP0005451_abnormal_body_composition	0.70792350
71	MP0000428_abnormal_craniofacial_morphol	0.69819667
72	MP0001765_abnormal_ion_homeostasis	0.69085663
73	MP0001881_abnormal_mammary_gland	0.67503473
74	MP0004036_abnormal_muscle_relaxation	0.66702810
75	MP0000759_abnormal_skeletal_muscle	0.66269938
76	MP0000653_abnormal_sex_gland	0.63959948
77	MP0005390_skeleton_phenotype	0.62252760
78	MP0000249_abnormal_blood_vessel	0.62112233
79	MP0004085_abnormal_heartbeat	0.61963164
80	MP0001243_abnormal_dermal_layer	0.61435365
81	MP0002933_joint_inflammation	0.59309763
82	MP0003077_abnormal_cell_cycle	0.59235493
83	MP0003385_abnormal_body_wall	0.58696352
84	MP0002925_abnormal_cardiovascular_devel	0.55793145
85	MP0009697_abnormal_copulation	0.55556643
86	MP0000026_abnormal_inner_ear	0.55120459
87	MP0002269_muscular_atrophy	0.54854045
88	MP0008874_decreased_physiological_sensi	0.54420517
89	MP0000613_abnormal_salivary_gland	0.53241966
90	MP0002115_abnormal_skeleton_extremities	0.52423542
91	MP0003448_altered_tumor_morphology	0.49970046
92	MP0002932_abnormal_joint_morphology	0.49946951
93	MP0003115_abnormal_respiratory_system	0.48463448
94	MP0000470_abnormal_stomach_morphology	0.46885302
95	MP0009115_abnormal_fat_cell	0.46838559
96	MP0008569_lethality_at_weaning	0.46541268
97	MP0002085_abnormal_embryonic_tissue	0.45949839
98	MP0001270_distended_abdomen	0.44837839
99	MP0003879_abnormal_hair_cell	0.44743509
100	MP0002998_abnormal_bone_remodeling	0.44370511

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	6.74166819
2	Premature rupture of membranes (HP:0001788)	5.43996965
3	Asymmetric septal hypertrophy (HP:0001670)	4.38375108
4	Protrusio acetabuli (HP:0003179)	4.24096459
5	Bell-shaped thorax (HP:0001591)	3.87511911
6	Atrophic scars (HP:0001075)	3.78440214
7	Ankle contracture (HP:0006466)	3.48909227
8	Resting tremor (HP:0002322)	3.35509580
9	Hypoplastic ischia (HP:0003175)	3.33982755
10	Bony spicule pigmentary retinopathy (HP:0007737)	3.22695087
11	Hypoalphalipoproteinemia (HP:0003233)	3.20860151
12	Hyperkalemia (HP:0002153)	3.15864999
13	Neonatal short-limb short stature (HP:0008921)	3.03815593
14	Progressive sensorineural hearing impairment (HP:0000408)	2.99048372
15	Unilateral renal agenesis (HP:0000122)	2.98390062
16	Soft skin (HP:0000977)	2.88735819
17	Attenuation of retinal blood vessels (HP:0007843)	2.82458747
18	Spinal rigidity (HP:0003306)	2.80618366
19	Abnormality of the ischium (HP:0003174)	2.80006595
20	Ectopia lentis (HP:0001083)	2.77366724
21	Type 1 muscle fiber predominance (HP:0003803)	2.73428630
22	Abnormality of the nasal mucosa (HP:0000433)	2.72146359
23	Bladder diverticulum (HP:0000015)	2.70247901
24	Achilles tendon contracture (HP:0001771)	2.69685163
25	Enlarged epiphyses (HP:0010580)	2.68890173
26	Renovascular hypertension (HP:0100817)	2.65787652
27	Aortic aneurysm (HP:0004942)	2.55604967
28	Ventricular tachycardia (HP:0004756)	2.54038193
29	Nasal polyposis (HP:0100582)	2.53740474
30	Bradycardia (HP:0001662)	2.52244280
31	Shallow orbits (HP:0000586)	2.49753430
32	Abnormality of dentin (HP:0010299)	2.46083796
33	Distal lower limb muscle weakness (HP:0009053)	2.40813410
34	Flattened epiphyses (HP:0003071)	2.38694299
35	Abnormality of the Achilles tendon (HP:0005109)	2.38030342
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.37644404
37	Insulin resistance (HP:0000855)	2.37586048
38	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.35103387
39	Azoospermia (HP:0000027)	2.29802635
40	Aortic dissection (HP:0002647)	2.27787904
41	Epiphyseal dysplasia (HP:0002656)	2.26209711
42	Hypertriglyceridemia (HP:0002155)	2.24685541
43	Follicular hyperkeratosis (HP:0007502)	2.23763435
44	Fragile skin (HP:0001030)	2.23609458
45	Genu recurvatum (HP:0002816)	2.22540495
46	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.22356319
47	Broad metatarsal (HP:0001783)	2.22014991
48	Absent epiphyses (HP:0010577)	2.21825804
49	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.21825804
50	Upper limb muscle weakness (HP:0003484)	2.21359736
51	Infertility (HP:0000789)	2.18012631
52	Cone-rod dystrophy (HP:0000548)	2.17734113
53	Wormian bones (HP:0002645)	2.16363065
54	Hyperextensible skin (HP:0000974)	2.11398621
55	Abnormality of the acetabulum (HP:0003170)	2.09973815
56	Facial shape deformation (HP:0011334)	2.08744090
57	Potter facies (HP:0002009)	2.08744090
58	Increased connective tissue (HP:0009025)	2.07825842
59	Atelectasis (HP:0100750)	2.07040161
60	Blue sclerae (HP:0000592)	2.03523253
61	Progressive hearing impairment (HP:0001730)	2.03259396
62	Mildly elevated creatine phosphokinase (HP:0008180)	2.00798264
63	Cervical subluxation (HP:0003308)	2.00489653
64	Slender build (HP:0001533)	1.99656410
65	Broad face (HP:0000283)	1.98005664
66	Male infertility (HP:0003251)	1.96188746
67	Protuberant abdomen (HP:0001538)	1.93482084
68	Abnormal spermatogenesis (HP:0008669)	1.91919250
69	Absent/shortened dynein arms (HP:0200106)	1.91421969
70	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.91421969
71	Upper limb amyotrophy (HP:0009129)	1.91016313
72	Distal upper limb amyotrophy (HP:0007149)	1.91016313
73	Flat capital femoral epiphysis (HP:0003370)	1.90541899
74	Acanthosis nigricans (HP:0000956)	1.89794715
75	Hyperacusis (HP:0010780)	1.89576161
76	Osteoarthritis (HP:0002758)	1.89331934
77	Natal tooth (HP:0000695)	1.88844532
78	Elbow flexion contracture (HP:0002987)	1.88541544
79	Emphysema (HP:0002097)	1.87645458
80	Vascular tortuosity (HP:0004948)	1.87111341
81	Peritonitis (HP:0002586)	1.86839229
82	Joint laxity (HP:0001388)	1.86402112
83	Abnormality of the costochondral junction (HP:0000919)	1.86094823
84	Overgrowth (HP:0001548)	1.85488128
85	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.85051443
86	Abnormality of femoral epiphyses (HP:0006499)	1.85051443
87	Bowel diverticulosis (HP:0005222)	1.83477704
88	Vertebral compression fractures (HP:0002953)	1.82245953
89	Hypoplastic left heart (HP:0004383)	1.81778712
90	Persistence of primary teeth (HP:0006335)	1.81727196
91	Nuclear cataract (HP:0100018)	1.80604971
92	Esophageal varix (HP:0002040)	1.80566708
93	Coronal craniosynostosis (HP:0004440)	1.79888568
94	Hepatitis (HP:0012115)	1.78505037
95	Turricephaly (HP:0000262)	1.78201818
96	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.76270793
97	Glossoptosis (HP:0000162)	1.75790210
98	Increased variability in muscle fiber diameter (HP:0003557)	1.75669155
99	Biconcave vertebral bodies (HP:0004586)	1.75625161
100	Short nail (HP:0001799)	1.75240691

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	DDR2	6.00546822
2	TESK1	5.47206690
3	PLK4	4.24730538
4	STK38	3.80676955
5	MAP4K2	2.45719152
6	CDK12	2.28757819
7	MYLK	2.28644011
8	STK38L	2.22886286
9	SMG1	2.05744151
10	INSRR	1.95319315
11	PRKD3	1.91306659
12	TTN	1.87665821
13	PDGFRA	1.86651735
14	LATS2	1.73861375
15	KSR2	1.73588455
16	MST1R	1.72280262
17	MAP3K9	1.61851560
18	WNK1	1.54792787
19	BRD4	1.49200782
20	TRIB3	1.47046734
21	NEK9	1.43621108
22	PAK2	1.43325360
23	PDPK1	1.36822490
24	MAP3K8	1.34709801
25	CDK7	1.33313863
26	MET	1.31507556
27	PNCK	1.29719956
28	DYRK1B	1.29434296
29	PIK3CG	1.25279173
30	ARAF	1.22339539
31	PTK2	1.19597645
32	RPS6KA2	1.18393694
33	ICK	1.16463203
34	PLK2	1.16287884
35	IRAK3	1.11383300
36	MOS	1.08946727
37	PTK2B	1.08299750
38	PAK4	1.07738241
39	CAMK1G	1.04111738
40	PRKG2	1.02851039
41	ABL2	0.98353505
42	TIE1	0.97660801
43	EEF2K	0.97540846
44	LATS1	0.96391288
45	ROCK1	0.96124393
46	PDK1	0.94926137
47	NTRK1	0.91899562
48	BRAF	0.90106429
49	RPS6KL1	0.89291512
50	RPS6KC1	0.89291512
51	FLT3	0.88682816
52	MTOR	0.85807667
53	NME2	0.80317259
54	ERN1	0.80121352
55	GRK7	0.79492699
56	RIPK1	0.79164631
57	MAPK11	0.78165294
58	MUSK	0.77915750
59	AKT2	0.76259447
60	RPS6KA6	0.69394693
61	CDK4	0.67623195
62	PRPF4B	0.67455950
63	AKT3	0.63946771
64	DAPK3	0.62871004
65	ROCK2	0.61113046
66	MAP3K13	0.60450917
67	MAP2K2	0.60226692
68	TLK1	0.59811636
69	MAPK15	0.59515426
70	PRKD2	0.59185803
71	TGFBR2	0.59151357
72	ZAK	0.59114518
73	RPS6KA1	0.54510583
74	SIK1	0.54358489
75	MAP2K1	0.52287663
76	MAP3K1	0.51254175
77	AURKA	0.50792086
78	TAF1	0.49607089
79	CDK9	0.44957003
80	TRPM7	0.43617241
81	PIM2	0.43230818
82	UHMK1	0.42306433
83	ERBB4	0.39103003
84	CHEK1	0.39098813
85	MAP3K2	0.36525091
86	CDC42BPA	0.35651240
87	MAPK1	0.34874266
88	CDK2	0.33818217
89	MAPK8	0.33276658
90	EPHA2	0.32195937
91	GSK3B	0.30673964
92	PDGFRB	0.29785677
93	PAK1	0.29298593
94	MAP3K11	0.28839244
95	DMPK	0.26792417
96	CDC7	0.26262740
97	PKN2	0.25218457
98	FGFR4	0.24614593
99	KIT	0.24288027
100	AKT1	0.23756485

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	8.19493592
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.65727655
3	ECM-receptor interaction_Homo sapiens_hsa04512	2.76741508
4	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.57679954
5	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.33702243
6	Focal adhesion_Homo sapiens_hsa04510	2.06321331
7	Butanoate metabolism_Homo sapiens_hsa00650	2.05432719
8	Sulfur relay system_Homo sapiens_hsa04122	1.81283111
9	Viral myocarditis_Homo sapiens_hsa05416	1.78475906
10	Protein digestion and absorption_Homo sapiens_hsa04974	1.70010115
11	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.68935491
12	Olfactory transduction_Homo sapiens_hsa04740	1.60992385
13	Phenylalanine metabolism_Homo sapiens_hsa00360	1.43586789
14	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.43424924
15	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.41505371
16	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.35023422
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.31951328
18	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.25201893
19	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.24186231
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.21915152
21	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.20893689
22	Allograft rejection_Homo sapiens_hsa05330	1.20032337
23	Small cell lung cancer_Homo sapiens_hsa05222	1.18084155
24	Bladder cancer_Homo sapiens_hsa05219	1.17874033
25	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.17127040
26	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.15099229
27	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.14843952
28	Fatty acid degradation_Homo sapiens_hsa00071	1.14659200
29	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.13896281
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.12046955
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.04793876
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04620143
33	Proteoglycans in cancer_Homo sapiens_hsa05205	1.02951438
34	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.02908327
35	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97789287
36	Viral carcinogenesis_Homo sapiens_hsa05203	0.97395674
37	Arginine biosynthesis_Homo sapiens_hsa00220	0.96956611
38	Arginine and proline metabolism_Homo sapiens_hsa00330	0.96517286
39	Graft-versus-host disease_Homo sapiens_hsa05332	0.95255103
40	Antigen processing and presentation_Homo sapiens_hsa04612	0.92373133
41	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.91314114
42	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.90932082
43	Type II diabetes mellitus_Homo sapiens_hsa04930	0.90685349
44	Endocytosis_Homo sapiens_hsa04144	0.88954434
45	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.88605364
46	Alcoholism_Homo sapiens_hsa05034	0.87203393
47	Toxoplasmosis_Homo sapiens_hsa05145	0.87176240
48	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.86675678
49	Renin-angiotensin system_Homo sapiens_hsa04614	0.85474658
50	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.84409400
51	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.83338181
52	Estrogen signaling pathway_Homo sapiens_hsa04915	0.79498157
53	Influenza A_Homo sapiens_hsa05164	0.78588115
54	RNA transport_Homo sapiens_hsa03013	0.77809706
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.77611721
56	Thyroid cancer_Homo sapiens_hsa05216	0.77378392
57	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.73224204
58	Adherens junction_Homo sapiens_hsa04520	0.72009064
59	Carbon metabolism_Homo sapiens_hsa01200	0.69533679
60	Galactose metabolism_Homo sapiens_hsa00052	0.67138283
61	VEGF signaling pathway_Homo sapiens_hsa04370	0.66564807
62	Tight junction_Homo sapiens_hsa04530	0.66041324
63	MicroRNAs in cancer_Homo sapiens_hsa05206	0.64624921
64	Prostate cancer_Homo sapiens_hsa05215	0.57683764
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56806668
66	Prion diseases_Homo sapiens_hsa05020	0.56697534
67	Basal cell carcinoma_Homo sapiens_hsa05217	0.55154843
68	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.54088478
69	MAPK signaling pathway_Homo sapiens_hsa04010	0.54063964
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.53878113
71	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.52915456
72	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.52680291
73	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.47447608
74	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.47321550
75	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.46431397
76	PPAR signaling pathway_Homo sapiens_hsa03320	0.46157690
77	Acute myeloid leukemia_Homo sapiens_hsa05221	0.45920785
78	Amoebiasis_Homo sapiens_hsa05146	0.44882653
79	Tyrosine metabolism_Homo sapiens_hsa00350	0.43934859
80	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.43700889
81	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.43699089
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43214009
83	Lysine degradation_Homo sapiens_hsa00310	0.41858269
84	Melanoma_Homo sapiens_hsa05218	0.41726370
85	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.41307680
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.41048467
87	HTLV-I infection_Homo sapiens_hsa05166	0.38488896
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.37875438
89	Pathways in cancer_Homo sapiens_hsa05200	0.35820971
90	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.33227698
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.33217827
92	Bile secretion_Homo sapiens_hsa04976	0.33129291
93	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.32505639
94	Melanogenesis_Homo sapiens_hsa04916	0.31515952
95	Apoptosis_Homo sapiens_hsa04210	0.31397467
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.29103510
97	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.29045174
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.27979459
99	Glioma_Homo sapiens_hsa05214	0.25269238
100	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.24207094

OXCT2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »