OXER1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)5.45403291
2positive regulation by symbiont of host defense response (GO:0052509)5.18189947
3modulation by symbiont of host defense response (GO:0052031)5.18189947
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.18189947
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.18189947
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.18189947
7modulation by symbiont of host immune response (GO:0052553)5.18189947
8negative regulation of cell killing (GO:0031342)5.12440965
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.12440965
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.08512738
11detection of other organism (GO:0098543)5.07432705
12detection of bacterium (GO:0016045)4.96138169
13neutrophil activation involved in immune response (GO:0002283)4.85182469
14positive regulation of gamma-delta T cell activation (GO:0046645)4.70543434
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.62661015
16antigen processing and presentation of endogenous antigen (GO:0019883)4.57217524
17detection of external biotic stimulus (GO:0098581)4.50810284
18macrophage activation involved in immune response (GO:0002281)4.41486644
19disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.35343595
20killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.35343595
21detection of molecule of bacterial origin (GO:0032490)4.33831798
22leukocyte migration involved in inflammatory response (GO:0002523)4.31031647
23neutrophil mediated immunity (GO:0002446)4.26318866
24response to peptidoglycan (GO:0032494)4.21693276
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16232639
26microglial cell activation (GO:0001774)4.12038102
27detection of biotic stimulus (GO:0009595)3.96523186
28regulation of B cell receptor signaling pathway (GO:0050855)3.87615412
29leukocyte aggregation (GO:0070486)3.81233772
30regulation of interferon-beta biosynthetic process (GO:0045357)3.78776881
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.78672082
32positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.76885526
33respiratory burst (GO:0045730)3.70164653
34neutrophil activation (GO:0042119)3.66151948
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.64198479
36response to host immune response (GO:0052572)3.64198479
37macrophage activation (GO:0042116)3.61256108
38positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.59978347
39regulation of gamma-delta T cell activation (GO:0046643)3.53753948
40complement activation, alternative pathway (GO:0006957)3.51785171
41immunoglobulin mediated immune response (GO:0016064)3.45456575
42negative regulation of interleukin-12 production (GO:0032695)3.44522386
43negative regulation of fibrinolysis (GO:0051918)3.44333955
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.42020546
45myeloid leukocyte mediated immunity (GO:0002444)3.39768476
46regulation of fibrinolysis (GO:0051917)3.35912380
47regulation of triglyceride catabolic process (GO:0010896)3.33555534
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.31481294
49response to host (GO:0075136)3.31481294
50response to host defenses (GO:0052200)3.31481294
51phospholipid efflux (GO:0033700)3.30587783
52granulocyte activation (GO:0036230)3.30366195
53response to interleukin-15 (GO:0070672)3.28229522
54negative regulation of leukocyte mediated immunity (GO:0002704)3.27501343
55regulation of mast cell degranulation (GO:0043304)3.27221227
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.25987547
57regulation of myeloid leukocyte mediated immunity (GO:0002886)3.24060399
58positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16449391
59myeloid cell activation involved in immune response (GO:0002275)3.13014662
60regulation of gamma-delta T cell differentiation (GO:0045586)3.11927529
61germinal center formation (GO:0002467)3.08071775
62production of molecular mediator involved in inflammatory response (GO:0002532)3.06442191
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.06380100
64negative regulation of phagocytosis (GO:0050765)3.02089550
65regulation of protein activation cascade (GO:2000257)3.00498893
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96905535
67regulation of mast cell activation involved in immune response (GO:0033006)2.96665048
68regulation of leukocyte degranulation (GO:0043300)2.96064900
69triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.94859687
70regulation of complement activation (GO:0030449)2.94788919
71positive regulation of mast cell activation (GO:0033005)2.93279832
72positive regulation of lipoprotein lipase activity (GO:0051006)2.90614544
73positive regulation of triglyceride lipase activity (GO:0061365)2.90614544
74negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.89632229
75regulation of interleukin-8 biosynthetic process (GO:0045414)2.89558285
76B cell receptor signaling pathway (GO:0050853)2.87916805
77epoxygenase P450 pathway (GO:0019373)2.83008488
78cellular response to interleukin-15 (GO:0071350)2.82912725
79negative regulation of B cell mediated immunity (GO:0002713)2.81880161
80negative regulation of immunoglobulin mediated immune response (GO:0002890)2.81880161
81negative regulation of erythrocyte differentiation (GO:0045647)2.80719205
82negative regulation of cytokine production involved in immune response (GO:0002719)2.79709181
83positive regulation of cellular amide metabolic process (GO:0034250)2.79047769
84cellular response to type I interferon (GO:0071357)2.78548900
85type I interferon signaling pathway (GO:0060337)2.78548900
86response to type I interferon (GO:0034340)2.78018962
87drug catabolic process (GO:0042737)2.76540732
88positive regulation of B cell differentiation (GO:0045579)2.76233885
89regulation of B cell differentiation (GO:0045577)2.72044262
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.71793483
91regulation of mast cell activation (GO:0033003)2.71680393
92exogenous drug catabolic process (GO:0042738)2.69718832
93negative regulation of interleukin-8 production (GO:0032717)2.68874808
94negative regulation of T cell mediated immunity (GO:0002710)2.68500041
95B cell mediated immunity (GO:0019724)2.67772717
96leukocyte degranulation (GO:0043299)2.66893124
97regulation of T-helper 2 cell differentiation (GO:0045628)2.66853718
98antigen processing and presentation via MHC class Ib (GO:0002475)2.66281799
99defense response to protozoan (GO:0042832)2.65193722
100negative regulation of innate immune response (GO:0045824)2.64777496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.78221216
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.97726134
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.50406592
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13213498
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.11353042
6VDR_21846776_ChIP-Seq_THP-1_Human2.94192201
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84142197
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.67050657
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59205258
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58739683
11VDR_24763502_ChIP-Seq_THP-1_Human2.57489246
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47039261
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45862774
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.43535624
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.38793605
16* SPI1_23547873_ChIP-Seq_NB4_Human2.32623263
17SPI1_23127762_ChIP-Seq_K562_Human2.31182294
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29620824
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.28269438
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.26369082
21SCL_19346495_ChIP-Seq_HPC-7_Human2.24970485
22* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10088935
23MAF_26560356_Chip-Seq_TH1_Human2.09623252
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.07655791
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03994987
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01074940
27MYC_22102868_ChIP-Seq_BL_Human1.98008345
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95200945
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.93499547
30RUNX_20019798_ChIP-Seq_JUKART_Human1.93321199
31UTX_26944678_Chip-Seq_JUKART_Human1.91995229
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91831546
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89171489
34TCF7_22412390_ChIP-Seq_EML_Mouse1.88596709
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87817675
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.84904545
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.84463287
38LXR_22292898_ChIP-Seq_THP-1_Human1.83122860
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.82331404
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81705051
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79523449
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76472228
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.69415762
44MYB_26560356_Chip-Seq_TH2_Human1.68850726
45MYB_26560356_Chip-Seq_TH1_Human1.66059466
46MAF_26560356_Chip-Seq_TH2_Human1.64918899
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64776484
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63852486
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60688805
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60168459
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58252997
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55423211
53KDM2B_26808549_Chip-Seq_DND41_Human1.54735427
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54044439
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52645353
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50655998
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47778336
58VDR_24787735_ChIP-Seq_THP-1_Human1.45632635
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43604346
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.41301397
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37769758
62BCL6_27268052_Chip-Seq_Bcells_Human1.37567701
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37083540
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33556205
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32512074
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30508625
67GATA3_27048872_Chip-Seq_THYMUS_Human1.29506048
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28247250
69BCOR_27268052_Chip-Seq_Bcells_Human1.28199654
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27867986
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26506211
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24750225
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22996772
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22549135
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19668674
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19504143
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18203565
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15331744
79GATA1_19941826_ChIP-Seq_K562_Human1.14250637
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11695050
81GATA1_22025678_ChIP-Seq_K562_Human1.10921813
82* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09359380
83* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09232897
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09039670
85SPI1_20517297_ChIP-Seq_HL60_Human1.07321766
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07148402
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06359366
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.06002454
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04835709
90P68_20966046_ChIP-Seq_HELA_Human1.04120477
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.02760981
92PU_27001747_Chip-Seq_BMDM_Mouse1.01710098
93GATA3_26560356_Chip-Seq_TH2_Human1.01640092
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00908626
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00744513
96EGR1_19374776_ChIP-ChIP_THP-1_Human0.99972245
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.98582579
98NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97647010
99RACK7_27058665_Chip-Seq_MCF-7_Human0.94285077
100SMC4_20622854_ChIP-Seq_HELA_Human0.90807205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.08856166
2MP0003436_decreased_susceptibility_to4.03573477
3MP0003303_peritoneal_inflammation3.61436999
4MP0002139_abnormal_hepatobiliary_system3.19210239
5MP0005360_urolithiasis3.05951557
6MP0002419_abnormal_innate_immunity2.98664258
7MP0001835_abnormal_antigen_presentation2.90972545
8MP0003191_abnormal_cellular_cholesterol2.78321677
9MP0009785_altered_susceptibility_to2.76510633
10MP0005025_abnormal_response_to2.67610903
11MP0005085_abnormal_gallbladder_physiolo2.60925335
12MP0000685_abnormal_immune_system2.46526874
13MP0002132_abnormal_respiratory_system2.43137399
14MP0001800_abnormal_humoral_immune2.42616807
15MP0001790_abnormal_immune_system2.42499006
16MP0005387_immune_system_phenotype2.42499006
17MP0005000_abnormal_immune_tolerance2.36452887
18MP0005365_abnormal_bile_salt2.31769725
19MP0005464_abnormal_platelet_physiology2.28676012
20MP0005671_abnormal_response_to2.27292703
21MP0003195_calcinosis2.19565076
22MP0006082_CNS_inflammation2.13362083
23MP0002723_abnormal_immune_serum2.13355285
24MP0003172_abnormal_lysosome_physiology2.12102526
25MP0002420_abnormal_adaptive_immunity2.06205903
26MP0001819_abnormal_immune_cell2.03852378
27MP0001533_abnormal_skeleton_physiology2.03162423
28MP0002452_abnormal_antigen_presenting2.02427737
29MP0005451_abnormal_body_composition1.98253240
30MP0002138_abnormal_hepatobiliary_system1.91113425
31MP0002148_abnormal_hypersensitivity_rea1.85153028
32MP0003183_abnormal_peptide_metabolism1.83830114
33MP0003300_gastrointestinal_ulcer1.80672964
34MP0010155_abnormal_intestine_physiology1.71000771
35MP0003252_abnormal_bile_duct1.69766037
36MP0001845_abnormal_inflammatory_respons1.67931380
37MP0002405_respiratory_system_inflammati1.67157095
38MP0009278_abnormal_bone_marrow1.63417792
39MP0008469_abnormal_protein_level1.63029150
40MP0008260_abnormal_autophagy1.60521943
41MP0005058_abnormal_lysosome_morphology1.60230389
42MP0009840_abnormal_foam_cell1.58826626
43MP0009764_decreased_sensitivity_to1.57445630
44MP0000716_abnormal_immune_system1.51363923
45MP0002398_abnormal_bone_marrow1.46609038
46MP0010329_abnormal_lipoprotein_level1.44542450
47MP0009333_abnormal_splenocyte_physiolog1.41939110
48MP0004883_abnormal_blood_vessel1.41428573
49MP0005377_hearing/vestibular/ear_phenot1.37862691
50MP0003878_abnormal_ear_physiology1.37862691
51MP0003075_altered_response_to1.36986447
52MP0005397_hematopoietic_system_phenotyp1.36068951
53MP0001545_abnormal_hematopoietic_system1.36068951
54MP0003763_abnormal_thymus_physiology1.35630675
55MP0003866_abnormal_defecation1.34635451
56MP0008875_abnormal_xenobiotic_pharmacok1.33569150
57MP0003806_abnormal_nucleotide_metabolis1.33463511
58MP0002277_abnormal_respiratory_mucosa1.32954663
59MP0002396_abnormal_hematopoietic_system1.32703271
60MP0004947_skin_inflammation1.28466137
61MP0003828_pulmonary_edema1.28101688
62MP0004381_abnormal_hair_follicle1.25729801
63MP0000689_abnormal_spleen_morphology1.24569436
64MP0002722_abnormal_immune_system1.22226885
65MP0001851_eye_inflammation1.22160881
66MP0000465_gastrointestinal_hemorrhage1.18811243
67MP0002429_abnormal_blood_cell1.18188944
68MP0000858_altered_metastatic_potential1.16671482
69MP0005164_abnormal_response_to1.14385536
70MP0002998_abnormal_bone_remodeling1.14257118
71MP0000609_abnormal_liver_physiology1.12125850
72MP0003690_abnormal_glial_cell1.04987610
73MP0001666_abnormal_nutrient_absorption1.00946641
74MP0005319_abnormal_enzyme/_coenzyme1.00375725
75MP0005166_decreased_susceptibility_to0.98889275
76MP0009763_increased_sensitivity_to0.96874252
77MP0000604_amyloidosis0.96459933
78MP0002118_abnormal_lipid_homeostasis0.96007654
79MP0004510_myositis0.91876108
80MP0001986_abnormal_taste_sensitivity0.91173561
81MP0005310_abnormal_salivary_gland0.90555443
82MP0000703_abnormal_thymus_morphology0.84892846
83MP0003656_abnormal_erythrocyte_physiolo0.80186122
84MP0001663_abnormal_digestive_system0.79884086
85MP0008874_decreased_physiological_sensi0.76405569
86MP0002933_joint_inflammation0.76091354
87MP0004130_abnormal_muscle_cell0.75491907
88MP0005390_skeleton_phenotype0.73335974
89MP0000249_abnormal_blood_vessel0.73012022
90MP0005083_abnormal_biliary_tract0.68673133
91MP0001853_heart_inflammation0.68331310
92MP0009642_abnormal_blood_homeostasis0.67141779
93MP0003879_abnormal_hair_cell0.67135522
94MP0005376_homeostasis/metabolism_phenot0.66762642
95MP0005584_abnormal_enzyme/coenzyme_acti0.66151200
96MP0000343_altered_response_to0.66122957
97MP0002971_abnormal_brown_adipose0.65708850
98MP0005076_abnormal_cell_differentiation0.64173533
99MP0000598_abnormal_liver_morphology0.64041569
100MP0005332_abnormal_amino_acid0.63408354

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)5.97519500
2Eczematoid dermatitis (HP:0000976)5.84595334
3Myositis (HP:0100614)5.28118857
4Recurrent abscess formation (HP:0002722)5.10738603
5Orchitis (HP:0100796)4.89900002
6Recurrent bacterial skin infections (HP:0005406)4.75093621
7Abnormality of macrophages (HP:0004311)4.74783508
8Deep venous thrombosis (HP:0002625)4.68309405
9Retrobulbar optic neuritis (HP:0100654)4.53548381
10Optic neuritis (HP:0100653)4.53548381
11Hypochromic microcytic anemia (HP:0004840)4.08550381
12Joint hemorrhage (HP:0005261)3.99950151
13Systemic lupus erythematosus (HP:0002725)3.98482388
14Chronic obstructive pulmonary disease (HP:0006510)3.92843675
15Obstructive lung disease (HP:0006536)3.92843675
16Gastrointestinal infarctions (HP:0005244)3.81772880
17Stomatitis (HP:0010280)3.74613778
18Meningitis (HP:0001287)3.71736320
19Elevated erythrocyte sedimentation rate (HP:0003565)3.71479074
20Hypochromic anemia (HP:0001931)3.68297996
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.65212105
22Mediastinal lymphadenopathy (HP:0100721)3.61007725
23Gingival bleeding (HP:0000225)3.55464129
24Keratoconjunctivitis sicca (HP:0001097)3.38621376
25Complement deficiency (HP:0004431)3.35987836
26Prolonged bleeding time (HP:0003010)3.35439805
27Prolonged partial thromboplastin time (HP:0003645)3.32642515
28Gingivitis (HP:0000230)3.28435039
29Recurrent fungal infections (HP:0002841)3.25115823
30Pulmonary embolism (HP:0002204)3.20837002
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.18666918
32Purpura (HP:0000979)3.18380421
33Recurrent skin infections (HP:0001581)3.15571518
34Encephalitis (HP:0002383)3.14707784
35Abnormality of complement system (HP:0005339)3.13712503
36Epistaxis (HP:0000421)3.13330614
37Increased IgE level (HP:0003212)3.12548632
38Vasculitis (HP:0002633)3.11251452
39Spontaneous hematomas (HP:0007420)3.11099283
40Keratoconjunctivitis (HP:0001096)3.07656266
41Urticaria (HP:0001025)3.05268641
42Glomerulonephritis (HP:0000099)2.87780592
43Hypobetalipoproteinemia (HP:0003563)2.85206525
44Hemorrhage of the eye (HP:0011885)2.80827304
45Pulmonary infiltrates (HP:0002113)2.79727584
46Amyloidosis (HP:0011034)2.75690964
47Peritonitis (HP:0002586)2.74822779
48Gangrene (HP:0100758)2.74555331
49Chest pain (HP:0100749)2.72803313
50Hemoptysis (HP:0002105)2.71985101
51Anorexia (HP:0002039)2.70352394
52Cellulitis (HP:0100658)2.67965817
53Hyperlipoproteinemia (HP:0010980)2.67740571
54Episodic fever (HP:0001954)2.62644424
55Abnormality of the common coagulation pathway (HP:0010990)2.57651083
56Xanthomatosis (HP:0000991)2.56799193
57Chronic mucocutaneous candidiasis (HP:0002728)2.55591942
58Recurrent cutaneous fungal infections (HP:0011370)2.55591942
59Arterial thrombosis (HP:0004420)2.52692796
60Granulocytopenia (HP:0001913)2.50969782
61Menorrhagia (HP:0000132)2.50686054
62Petechiae (HP:0000967)2.49925642
63Thrombophlebitis (HP:0004418)2.46112930
64Increased serum ferritin (HP:0003281)2.38265925
65Leukocytosis (HP:0001974)2.38003847
66Inflammation of the large intestine (HP:0002037)2.34920488
67Microcytic anemia (HP:0001935)2.33560449
68Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32658438
69Gastrointestinal inflammation (HP:0004386)2.31340079
70Abnormality of iron homeostasis (HP:0011031)2.30917586
71Abnormality of the pleura (HP:0002103)2.29976863
72Abnormal platelet volume (HP:0011876)2.27647167
73Pustule (HP:0200039)2.26236208
74Hypergammaglobulinemia (HP:0010702)2.23945915
75Increased IgM level (HP:0003496)2.20134890
76Abnormality of pyrimidine metabolism (HP:0004353)2.11776847
77Osteomyelitis (HP:0002754)2.10858547
78Loss of speech (HP:0002371)2.10563341
79Abnormality of the peritoneum (HP:0002585)2.08545186
80Eosinophilia (HP:0001880)2.07127392
81Sepsis (HP:0100806)2.06827228
82Increased cerebral lipofuscin (HP:0011813)2.06442886
83Hypertriglyceridemia (HP:0002155)2.03601810
84Polycythemia (HP:0001901)2.02495200
85Glomerulopathy (HP:0100820)2.02302614
86Joint swelling (HP:0001386)2.01551393
87Nephritis (HP:0000123)2.01416681
88Acne (HP:0001061)2.01411193
89Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00590462
90Abnormality of polysaccharide metabolism (HP:0011012)2.00590462
91Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00590462
92Periodontitis (HP:0000704)2.00568699
93Dysostosis multiplex (HP:0000943)2.00401174
94Metaphyseal cupping (HP:0003021)1.96884912
95Myocardial infarction (HP:0001658)1.95098304
96Mucopolysacchariduria (HP:0008155)1.94700350
97Urinary glycosaminoglycan excretion (HP:0003541)1.94700350
98Thrombocytosis (HP:0001894)1.94001388
99Abnormality of transition element cation homeostasis (HP:0011030)1.92514884
100Recurrent viral infections (HP:0004429)1.91064581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.62906943
2ERN14.29252930
3MAP4K13.49231632
4IRAK43.29839880
5MAP2K32.99133913
6TYK22.88139126
7BLK2.73221387
8TNK22.55435633
9CSK2.45278108
10FES2.20305267
11GRK62.17677157
12ZAP701.98365436
13PRPF4B1.95970262
14EPHB11.94613856
15TAOK11.93911365
16MAP3K31.87493351
17MAP3K111.83093716
18BTK1.66583792
19HCK1.65106931
20SYK1.56973347
21FGR1.56666676
22TBK11.46418924
23JAK31.46295744
24TRIB31.46182604
25CSF1R1.43259168
26FGFR41.42440107
27KIT1.37991645
28MAP3K11.37048092
29MAP3K141.32173384
30JAK21.30269877
31KSR21.28737629
32LYN1.28598775
33IKBKE1.24983485
34TXK1.21966832
35TAOK31.17247275
36PTK61.14038303
37SIK31.12582150
38LCK1.12201773
39MATK1.11549983
40SIK21.09444820
41YES11.06084029
42IRAK21.03801044
43JAK11.03114899
44SIK11.02566555
45IRAK11.01620689
46MARK20.98672958
47PRKD20.98127715
48MAP3K130.97105951
49PDPK10.96654223
50PDK10.95737983
51SMG10.95734026
52TAOK20.95593119
53ITK0.87775213
54MAP3K60.86197073
55TESK20.85886708
56PIK3CG0.84845087
57FGFR30.82490120
58MAP3K20.82335166
59MARK30.81949476
60MAP2K40.76049666
61CDC42BPA0.72776715
62DYRK1B0.72543272
63MAP3K70.70108835
64TEC0.70047085
65IKBKB0.68762193
66PRKG20.68750490
67FYN0.67942102
68STK380.65780031
69TGFBR20.65506095
70CDK190.65228489
71MAPK120.64262714
72CDK120.63868516
73DAPK20.63668992
74MAP2K60.63306687
75IRAK30.61011008
76RET0.58525324
77PTK2B0.57123010
78ICK0.56000624
79RIPK10.54154606
80STK100.50772767
81HIPK20.50153800
82PRKCQ0.49885158
83LRRK20.49858929
84RPS6KC10.48596762
85RPS6KL10.48596762
86MAP3K50.48563517
87MAPK70.48362194
88PRKAA20.46051223
89BMPR20.45132839
90PRKCZ0.44923744
91STK110.44241748
92SGK30.43956252
93RPS6KA60.40973296
94MAPK110.39617701
95EPHA30.39492785
96MAPKAPK20.36110157
97BMX0.30069561
98MAPK40.29559042
99RPS6KA10.29474257
100PRKCD0.29005932

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.89583360
2Complement and coagulation cascades_Homo sapiens_hsa046103.04588666
3Leishmaniasis_Homo sapiens_hsa051402.66255379
4Osteoclast differentiation_Homo sapiens_hsa043802.62154227
5Other glycan degradation_Homo sapiens_hsa005111.90403994
6Allograft rejection_Homo sapiens_hsa053301.89281670
7B cell receptor signaling pathway_Homo sapiens_hsa046621.87681412
8Graft-versus-host disease_Homo sapiens_hsa053321.86072259
9Caffeine metabolism_Homo sapiens_hsa002321.81325157
10Tuberculosis_Homo sapiens_hsa051521.79706625
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77317005
12Autoimmune thyroid disease_Homo sapiens_hsa053201.72589016
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71465629
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68722769
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61063319
16Malaria_Homo sapiens_hsa051441.61004132
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.59610374
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58600996
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.52963437
20Primary immunodeficiency_Homo sapiens_hsa053401.50579967
21Acute myeloid leukemia_Homo sapiens_hsa052211.40654622
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.39281669
23African trypanosomiasis_Homo sapiens_hsa051431.37297493
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37284910
25Hematopoietic cell lineage_Homo sapiens_hsa046401.32896972
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30504526
27Retinol metabolism_Homo sapiens_hsa008301.28727128
28Type I diabetes mellitus_Homo sapiens_hsa049401.28511106
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27966204
30Chemokine signaling pathway_Homo sapiens_hsa040621.26985326
31Pertussis_Homo sapiens_hsa051331.26466595
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24719056
33Measles_Homo sapiens_hsa051621.24477622
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22137169
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.20929961
36Toxoplasmosis_Homo sapiens_hsa051451.16880009
37Antigen processing and presentation_Homo sapiens_hsa046121.15930254
38Influenza A_Homo sapiens_hsa051641.12523544
39Phagosome_Homo sapiens_hsa041451.12417116
40Chemical carcinogenesis_Homo sapiens_hsa052041.12284567
41Fatty acid degradation_Homo sapiens_hsa000711.06568047
42Legionellosis_Homo sapiens_hsa051341.02168041
43Phenylalanine metabolism_Homo sapiens_hsa003601.01766270
44Arginine biosynthesis_Homo sapiens_hsa002201.00694513
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99686935
46PPAR signaling pathway_Homo sapiens_hsa033200.98999588
47T cell receptor signaling pathway_Homo sapiens_hsa046600.98807395
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.98368416
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97724316
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.96191000
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.95386756
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95319822
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95288173
54Viral myocarditis_Homo sapiens_hsa054160.95270774
55Herpes simplex infection_Homo sapiens_hsa051680.94262589
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92685126
57Platelet activation_Homo sapiens_hsa046110.92669466
58Asthma_Homo sapiens_hsa053100.92609969
59Starch and sucrose metabolism_Homo sapiens_hsa005000.92400173
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91084883
61TNF signaling pathway_Homo sapiens_hsa046680.90618839
62Hepatitis C_Homo sapiens_hsa051600.90038469
63Arachidonic acid metabolism_Homo sapiens_hsa005900.89796014
64Histidine metabolism_Homo sapiens_hsa003400.83575529
65Lysosome_Homo sapiens_hsa041420.82586992
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82050057
67Bile secretion_Homo sapiens_hsa049760.81184479
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80589397
69Non-small cell lung cancer_Homo sapiens_hsa052230.79244516
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.78837600
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.77183456
72Insulin resistance_Homo sapiens_hsa049310.73967327
73Amoebiasis_Homo sapiens_hsa051460.69298319
74Tyrosine metabolism_Homo sapiens_hsa003500.66296542
75Hepatitis B_Homo sapiens_hsa051610.65823859
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65639365
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.64863269
78Salmonella infection_Homo sapiens_hsa051320.59616637
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.58619891
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58358939
81ABC transporters_Homo sapiens_hsa020100.57557675
82VEGF signaling pathway_Homo sapiens_hsa043700.54799783
83Rheumatoid arthritis_Homo sapiens_hsa053230.53496038
84Notch signaling pathway_Homo sapiens_hsa043300.52743090
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52223643
86Apoptosis_Homo sapiens_hsa042100.52019069
87Chronic myeloid leukemia_Homo sapiens_hsa052200.51999175
88Pancreatic cancer_Homo sapiens_hsa052120.51496177
89Linoleic acid metabolism_Homo sapiens_hsa005910.51319332
90Prion diseases_Homo sapiens_hsa050200.51319016
91Pentose phosphate pathway_Homo sapiens_hsa000300.49883420
92Fat digestion and absorption_Homo sapiens_hsa049750.48317090
93Shigellosis_Homo sapiens_hsa051310.47437571
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47042633
95Prolactin signaling pathway_Homo sapiens_hsa049170.46624555
96Galactose metabolism_Homo sapiens_hsa000520.45754333
97Renin-angiotensin system_Homo sapiens_hsa046140.45480737
98Tryptophan metabolism_Homo sapiens_hsa003800.43349820
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41662475
100Glycerolipid metabolism_Homo sapiens_hsa005610.38979221

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