OXNAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)6.90889849
2negative thymic T cell selection (GO:0045060)6.46281875
3lysine metabolic process (GO:0006553)6.23930964
4lysine catabolic process (GO:0006554)6.23930964
5positive regulation of gamma-delta T cell activation (GO:0046645)6.15312440
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.10098257
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.99153949
8negative regulation of cell killing (GO:0031342)5.99153949
9tricarboxylic acid cycle (GO:0006099)5.83885239
10positive T cell selection (GO:0043368)5.45777273
11regulation of gamma-delta T cell differentiation (GO:0045586)5.40905052
12regulation of B cell receptor signaling pathway (GO:0050855)5.29621218
13aspartate family amino acid catabolic process (GO:0009068)5.15588824
14positive regulation of granulocyte differentiation (GO:0030854)5.08974494
152-oxoglutarate metabolic process (GO:0006103)5.00332328
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88626772
17NADH metabolic process (GO:0006734)4.82304654
18T cell selection (GO:0045058)4.77637862
19L-phenylalanine metabolic process (GO:0006558)4.76419800
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.76419800
21regulation of gamma-delta T cell activation (GO:0046643)4.71791575
22fatty acid beta-oxidation (GO:0006635)4.70956910
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.70290028
24L-phenylalanine catabolic process (GO:0006559)4.70290028
25glyoxylate metabolic process (GO:0046487)4.67573585
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.65895356
27negative regulation of T cell mediated immunity (GO:0002710)4.64095281
28regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.57505218
29cysteine metabolic process (GO:0006534)4.48331901
30glycine metabolic process (GO:0006544)4.44877084
31response to interleukin-15 (GO:0070672)4.44104121
32regulation of regulatory T cell differentiation (GO:0045589)4.41658192
33thymic T cell selection (GO:0045061)4.40791145
34positive thymic T cell selection (GO:0045059)4.38399830
35cellular response to interleukin-15 (GO:0071350)4.38210521
36carnitine shuttle (GO:0006853)4.37555246
37tolerance induction (GO:0002507)4.37371638
38acetyl-CoA metabolic process (GO:0006084)4.36796110
39amino-acid betaine metabolic process (GO:0006577)4.35232689
40oxaloacetate metabolic process (GO:0006107)4.31395445
41branched-chain amino acid catabolic process (GO:0009083)4.28175068
42serine family amino acid catabolic process (GO:0009071)4.26229316
43fatty acid transmembrane transport (GO:1902001)4.22808780
44valine metabolic process (GO:0006573)4.21046696
45fatty acid oxidation (GO:0019395)4.20041057
46regulation of alpha-beta T cell proliferation (GO:0046640)4.19737153
47T cell migration (GO:0072678)4.17963173
48positive regulation of alpha-beta T cell proliferation (GO:0046641)4.17529455
49fatty acid catabolic process (GO:0009062)4.15761386
50tricarboxylic acid metabolic process (GO:0072350)4.14880902
51lipid oxidation (GO:0034440)4.11296088
52regulation of acyl-CoA biosynthetic process (GO:0050812)4.06976283
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.06219602
54aromatic amino acid family catabolic process (GO:0009074)4.05187342
55short-chain fatty acid metabolic process (GO:0046459)4.03199730
56regulation of isotype switching to IgG isotypes (GO:0048302)4.03032079
57serine family amino acid metabolic process (GO:0009069)4.00782638
58kynurenine metabolic process (GO:0070189)4.00175624
59carnitine metabolic process (GO:0009437)3.98430330
60regulation of coenzyme metabolic process (GO:0051196)3.96068192
61regulation of cofactor metabolic process (GO:0051193)3.96068192
62serine family amino acid biosynthetic process (GO:0009070)3.95680150
63branched-chain amino acid metabolic process (GO:0009081)3.95588318
64cellular ketone body metabolic process (GO:0046950)3.94235868
65succinate metabolic process (GO:0006105)3.90306056
66alpha-beta T cell differentiation (GO:0046632)3.85951533
67interferon-gamma production (GO:0032609)3.85544546
68alpha-linolenic acid metabolic process (GO:0036109)3.82971087
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.80271386
70monocarboxylic acid catabolic process (GO:0072329)3.79569339
71activated T cell proliferation (GO:0050798)3.76033814
72negative regulation of lymphocyte mediated immunity (GO:0002707)3.75298618
73antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.74489096
74homocysteine metabolic process (GO:0050667)3.74260009
75biotin metabolic process (GO:0006768)3.73932595
76negative regulation of fatty acid biosynthetic process (GO:0045717)3.72924555
77alpha-amino acid catabolic process (GO:1901606)3.72151638
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.71633185
79alpha-beta T cell activation (GO:0046631)3.70259948
80oxidative phosphorylation (GO:0006119)3.65120331
81amino-acid betaine transport (GO:0015838)3.63755195
82carnitine transport (GO:0015879)3.63755195
83T cell receptor signaling pathway (GO:0050852)3.59514935
84regulation of triglyceride catabolic process (GO:0010896)3.59396599
85carnitine transmembrane transport (GO:1902603)3.57898032
86regulation of fatty acid oxidation (GO:0046320)3.57868243
87regulation of interleukin-2 biosynthetic process (GO:0045076)3.57817241
88regulation of sequestering of triglyceride (GO:0010889)3.57765337
89sulfur amino acid catabolic process (GO:0000098)3.56410754
90triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.54960058
91cellular amino acid catabolic process (GO:0009063)3.54087577
92positive regulation of T cell differentiation in thymus (GO:0033089)3.50798334
93leukocyte aggregation (GO:0070486)3.48270840
94ethanol oxidation (GO:0006069)3.48224622
95bile acid biosynthetic process (GO:0006699)3.48085922
96indole-containing compound catabolic process (GO:0042436)3.47729585
97indolalkylamine catabolic process (GO:0046218)3.47729585
98tryptophan catabolic process (GO:0006569)3.47729585
99carboxylic acid catabolic process (GO:0046395)3.46501168
100organic acid catabolic process (GO:0016054)3.46501168
101positive regulation of interleukin-2 production (GO:0032743)3.45280473
102positive regulation of tolerance induction (GO:0002645)3.40741417
103regulation of T cell tolerance induction (GO:0002664)3.39321501
104antigen processing and presentation of endogenous antigen (GO:0019883)3.38901024
105fatty acid homeostasis (GO:0055089)3.38135712
106antigen receptor-mediated signaling pathway (GO:0050851)3.37784014
107ketone body metabolic process (GO:1902224)3.37485262
108regulation of B cell differentiation (GO:0045577)3.35105846
109hepatocyte apoptotic process (GO:0097284)3.34116356
110tryptophan metabolic process (GO:0006568)3.32157103
111mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31866112
112aspartate family amino acid metabolic process (GO:0009066)3.30079381
113B cell receptor signaling pathway (GO:0050853)3.29693846
114positive regulation of humoral immune response (GO:0002922)3.29618470
115antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.29537438
116T cell differentiation (GO:0030217)3.28124108
117phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.28112258
118negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.26915791
119mast cell activation (GO:0045576)3.25946315
120regulation of sulfur metabolic process (GO:0042762)3.25321323
121quaternary ammonium group transport (GO:0015697)3.25037344
122dicarboxylic acid metabolic process (GO:0043648)3.20706473
123urea cycle (GO:0000050)3.18844783
124urea metabolic process (GO:0019627)3.18844783
125histone mRNA catabolic process (GO:0071044)3.18119703
126folic acid-containing compound biosynthetic process (GO:0009396)3.17419753
127L-serine metabolic process (GO:0006563)3.16851734
128negative regulation of fatty acid metabolic process (GO:0045922)3.16323228
129glutamate metabolic process (GO:0006536)3.15272936
130regulation of granulocyte differentiation (GO:0030852)3.15270108
131positive regulation of fatty acid beta-oxidation (GO:0032000)3.15163635
132coenzyme catabolic process (GO:0009109)3.14706347
133cellular modified amino acid catabolic process (GO:0042219)3.14680793
134positive regulation of fatty acid oxidation (GO:0046321)3.11865015
135sarcomere organization (GO:0045214)3.11222642
136NAD metabolic process (GO:0019674)3.10534760
137folic acid metabolic process (GO:0046655)3.08842334
138regulation of T cell receptor signaling pathway (GO:0050856)3.08140744
139positive regulation of B cell differentiation (GO:0045579)3.07922196
140dicarboxylic acid biosynthetic process (GO:0043650)3.07649775
141aromatic amino acid family metabolic process (GO:0009072)3.04787450
142nitrogen cycle metabolic process (GO:0071941)3.04461183
143negative regulation of adaptive immune response (GO:0002820)3.01584257
144negative regulation of B cell proliferation (GO:0030889)2.99106105
145T cell homeostasis (GO:0043029)2.97761427
146negative regulation of T cell apoptotic process (GO:0070233)2.97409508
147lymph node development (GO:0048535)2.97295692
148acylglycerol homeostasis (GO:0055090)2.96735987
149triglyceride homeostasis (GO:0070328)2.96735987
150regulation of interleukin-12 biosynthetic process (GO:0045075)2.94189180
151energy coupled proton transport, down electrochemical gradient (GO:0015985)2.94155593
152ATP synthesis coupled proton transport (GO:0015986)2.94155593
153mast cell activation involved in immune response (GO:0002279)2.94095709
154mast cell degranulation (GO:0043303)2.94095709
155regulation of tolerance induction (GO:0002643)2.93993649
156regulation of T cell mediated cytotoxicity (GO:0001914)2.93488193
157negative regulation of leukocyte mediated immunity (GO:0002704)2.92221625
158respiratory electron transport chain (GO:0022904)2.91136356
159bile acid metabolic process (GO:0008206)2.90240691
160negative regulation of fibrinolysis (GO:0051918)2.89847727
161one-carbon metabolic process (GO:0006730)2.89768121
162thioester metabolic process (GO:0035383)2.88785365
163acyl-CoA metabolic process (GO:0006637)2.88785365
164drug transmembrane transport (GO:0006855)2.88003665
165regulation of fatty acid beta-oxidation (GO:0031998)2.87970446
1664-hydroxyproline metabolic process (GO:0019471)2.86732292
167positive regulation of interleukin-4 production (GO:0032753)2.82442354
168positive regulation of alpha-beta T cell activation (GO:0046635)2.81818623
169regulation of alpha-beta T cell activation (GO:0046634)2.80072000
170dosage compensation (GO:0007549)2.79280536
171histone H3-K36 demethylation (GO:0070544)2.77025315
172CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.73400532
173positive regulation of isotype switching (GO:0045830)2.72071122
174CD4-positive, alpha-beta T cell activation (GO:0035710)2.70789441
175histone-serine phosphorylation (GO:0035404)2.69923912
176T cell activation (GO:0042110)2.69682469
177CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.68306902
178T-helper cell differentiation (GO:0042093)2.68306902
179natural killer cell differentiation (GO:0001779)2.68062110
180V(D)J recombination (GO:0033151)2.67477745
181negative regulation of B cell mediated immunity (GO:0002713)2.64326550
182negative regulation of immunoglobulin mediated immune response (GO:0002890)2.64326550
183positive regulation of T cell cytokine production (GO:0002726)2.64141117
184nuclear pore complex assembly (GO:0051292)2.60861347
185regulation of T cell mediated immunity (GO:0002709)2.60469530
186establishment of protein localization to Golgi (GO:0072600)2.60375320
187protein K63-linked deubiquitination (GO:0070536)2.60109546
188positive regulation of T cell mediated immunity (GO:0002711)2.57483261
189nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.56652457
190regulation of leukocyte mediated cytotoxicity (GO:0001910)2.55844566
191positive regulation of DNA recombination (GO:0045911)2.53959889
192regulation of interleukin-2 production (GO:0032663)2.53656976
193dendritic cell migration (GO:0036336)2.52903485
194myeloid dendritic cell activation (GO:0001773)2.51566898
195dendritic cell chemotaxis (GO:0002407)2.51227806
196peptidyl-lysine trimethylation (GO:0018023)2.51190017
197protein K48-linked deubiquitination (GO:0071108)2.50144789
198protein targeting to Golgi (GO:0000042)2.49567740
199positive regulation of T cell mediated cytotoxicity (GO:0001916)2.49407181
200rRNA catabolic process (GO:0016075)2.48229863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.54217048
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.44890707
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.43319306
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.39642880
5RXR_22158963_ChIP-Seq_LIVER_Mouse4.22092824
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.00258755
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.90222578
8* RUNX_20019798_ChIP-Seq_JUKART_Human3.54420584
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.33608688
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33130294
11MYB_26560356_Chip-Seq_TH2_Human3.25388128
12E2F7_22180533_ChIP-Seq_HELA_Human3.25268340
13* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.22325553
14LXR_22158963_ChIP-Seq_LIVER_Mouse3.11698142
15* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.02516976
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.98341681
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.85836952
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.85816847
19* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.56615265
20* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53216885
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52053055
22MYB_26560356_Chip-Seq_TH1_Human2.50622655
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.48699824
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.47652047
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40498110
26* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38202409
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34302193
28* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.34015889
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22861616
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22172007
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13897293
32IRF8_21731497_ChIP-ChIP_J774_Mouse2.11685611
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08625157
34GATA3_27048872_Chip-Seq_THYMUS_Human2.05861700
35NOTCH1_21737748_ChIP-Seq_TLL_Human2.05258167
36STAT3_1855785_ChIP-Seq_MESCs_Mouse2.04407665
37ZNF263_19887448_ChIP-Seq_K562_Human2.03236423
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02147382
39ETS1_20019798_ChIP-Seq_JURKAT_Human2.01200803
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98689673
41* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93764081
42GATA3_26560356_Chip-Seq_TH2_Human1.92386833
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.89786954
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88762538
45AR_21909140_ChIP-Seq_LNCAP_Human1.88584824
46MAF_26560356_Chip-Seq_TH1_Human1.87349166
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.86797232
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.86459530
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.85100396
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81339618
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79230847
52UTX_26944678_Chip-Seq_JUKART_Human1.78825790
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76425428
54SPI1_23547873_ChIP-Seq_NB4_Human1.75438860
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75317748
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.73446045
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.72135653
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65762197
59SCL_19346495_ChIP-Seq_HPC-7_Human1.64557943
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61777337
61CLOCK_20551151_ChIP-Seq_293T_Human1.60611445
62* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60206727
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59551390
64ELK1_19687146_ChIP-ChIP_HELA_Human1.59059134
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58622835
66* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56702286
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56490049
68DCP1A_22483619_ChIP-Seq_HELA_Human1.56149540
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.55013131
70* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51023068
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50411870
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48915824
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48344589
74XRN2_22483619_ChIP-Seq_HELA_Human1.47204666
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46892366
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45248705
77MAF_26560356_Chip-Seq_TH2_Human1.44812291
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43366860
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43028583
80* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40602854
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40589556
82* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40272627
83IRF8_27001747_Chip-Seq_BMDM_Mouse1.39847856
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37694359
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37550968
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36329537
87MYC_22102868_ChIP-Seq_BL_Human1.35937617
88GABP_19822575_ChIP-Seq_HepG2_Human1.35304112
89* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34771669
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.33121733
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30425159
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.30305134
93FOXP3_21729870_ChIP-Seq_TREG_Human1.29929121
94MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26921761
95* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26479204
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25620541
97* VDR_23849224_ChIP-Seq_CD4+_Human1.24550079
98TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.18655954
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18535625
100BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16005901
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14706036
102GATA3_26560356_Chip-Seq_TH1_Human1.10389713
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09762857
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06088558
105KDM5A_27292631_Chip-Seq_BREAST_Human1.06002115
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05162759
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04710109
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03689493
109SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03494286
110ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03126755
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.02783210
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02707853
113SMAD_19615063_ChIP-ChIP_OVARY_Human1.01533101
114YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01434216
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01331933
116RUNX1_22412390_ChIP-Seq_EML_Mouse1.00671140
117CIITA_25753668_ChIP-Seq_RAJI_Human0.99512177
118GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98407799
119NFE2_27457419_Chip-Seq_LIVER_Mouse0.97062635
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96834665
121PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96063142
122E2F1_21310950_ChIP-Seq_MCF-7_Human0.95154079
123ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94465717
124PU_27001747_Chip-Seq_BMDM_Mouse0.94074486
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93770386
126SALL4_22934838_ChIP-ChIP_CD34+_Human0.93631232
127SPI1_23127762_ChIP-Seq_K562_Human0.93588482
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93497576
129* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93297694
130PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93050149
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92534210
132VDR_22108803_ChIP-Seq_LS180_Human0.92171795
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91871957
134* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90443302
135TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89710712
136GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89441560
137TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89150559
138MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89111825
139TFEB_21752829_ChIP-Seq_HELA_Human0.88853192
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86905261
141* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86088163
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85594040
143* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84272947
144SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84068468
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83943176
146KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83485351
147OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83381663
148CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83113547
149GATA1_22025678_ChIP-Seq_K562_Human0.83015348
150* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82726683
151ATF3_27146783_Chip-Seq_COLON_Human0.82308078
152MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.81979049
153KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.81798567
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81736952
155ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81700783
156HNF4A_19822575_ChIP-Seq_HepG2_Human0.80376137
157IRF1_19129219_ChIP-ChIP_H3396_Human0.79311686
158NANOG_21062744_ChIP-ChIP_HESCs_Human0.78725147
159BP1_19119308_ChIP-ChIP_Hs578T_Human0.78417708
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77861511
161SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.77749883
162* TBX20_22328084_ChIP-Seq_HEART_Mouse0.77748708
163* TBX20_22080862_ChIP-Seq_HEART_Mouse0.77748708
164CRX_20693478_ChIP-Seq_RETINA_Mouse0.77300047
165TTF2_22483619_ChIP-Seq_HELA_Human0.75959031
166TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75868754
167* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.75792787
168RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75764021
169OCT4_21477851_ChIP-Seq_ESCs_Mouse0.72362145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.16720572
2MP0002139_abnormal_hepatobiliary_system5.04876626
3MP0005360_urolithiasis4.93276014
4MP0003806_abnormal_nucleotide_metabolis4.68640517
5MP0005085_abnormal_gallbladder_physiolo4.11368986
6MP0002837_dystrophic_cardiac_calcinosis4.06295548
7MP0005365_abnormal_bile_salt3.92444067
8MP0005671_abnormal_response_to3.84147696
9MP0003646_muscle_fatigue3.80208499
10MP0008057_abnormal_DNA_replication3.27679705
11MP0001835_abnormal_antigen_presentation3.02802896
12MP0004084_abnormal_cardiac_muscle3.01073577
13MP0001800_abnormal_humoral_immune2.91720816
14MP0008875_abnormal_xenobiotic_pharmacok2.80943434
15MP0006036_abnormal_mitochondrial_physio2.72282859
16MP0005332_abnormal_amino_acid2.61534807
17MP0000703_abnormal_thymus_morphology2.59921913
18MP0003724_increased_susceptibility_to2.57261881
19MP0002009_preneoplasia2.44534576
20MP0004215_abnormal_myocardial_fiber2.44062639
21MP0005330_cardiomyopathy2.43296975
22MP0002398_abnormal_bone_marrow2.40543581
23MP0005000_abnormal_immune_tolerance2.38860807
24MP0003436_decreased_susceptibility_to2.38187574
25MP0010329_abnormal_lipoprotein_level2.36709196
26MP0003252_abnormal_bile_duct2.36338084
27MP0002723_abnormal_immune_serum2.35261297
28MP0002420_abnormal_adaptive_immunity2.32393131
29MP0001819_abnormal_immune_cell2.30852220
30MP0001873_stomach_inflammation2.25404014
31MP0004130_abnormal_muscle_cell2.23938276
32MP0004381_abnormal_hair_follicle2.23439909
33MP0009840_abnormal_foam_cell2.18032872
34MP0009333_abnormal_splenocyte_physiolog2.17189782
35MP0002452_abnormal_antigen_presenting2.16079655
36MP0000751_myopathy2.15476848
37MP0004036_abnormal_muscle_relaxation2.14811838
38MP0005670_abnormal_white_adipose2.10834124
39MP0003195_calcinosis2.10204226
40MP0000689_abnormal_spleen_morphology2.10052164
41MP0000716_abnormal_immune_system2.08849436
42MP0002166_altered_tumor_susceptibility2.08659916
43MP0005075_abnormal_melanosome_morpholog2.04866604
44MP0002722_abnormal_immune_system2.03385306
45MP0000569_abnormal_digit_pigmentation2.02192205
46MP0003866_abnormal_defecation2.01337715
47MP0009785_altered_susceptibility_to1.92202933
48MP0002269_muscular_atrophy1.91528802
49MP0005666_abnormal_adipose_tissue1.89143994
50MP0002396_abnormal_hematopoietic_system1.88480447
51MP0005025_abnormal_response_to1.85953541
52MP0002405_respiratory_system_inflammati1.85808365
53MP0001790_abnormal_immune_system1.84935433
54MP0005387_immune_system_phenotype1.84935433
55MP0006035_abnormal_mitochondrial_morpho1.80113338
56MP0005083_abnormal_biliary_tract1.78378464
57MP0008877_abnormal_DNA_methylation1.74363752
58MP0000685_abnormal_immune_system1.73317005
59MP0002429_abnormal_blood_cell1.70908921
60MP0000749_muscle_degeneration1.70798756
61MP0001666_abnormal_nutrient_absorption1.70775806
62MP0005319_abnormal_enzyme/_coenzyme1.70188275
63MP0003221_abnormal_cardiomyocyte_apopto1.65289498
64MP0004087_abnormal_muscle_fiber1.64018177
65MP0000609_abnormal_liver_physiology1.62437113
66MP0000465_gastrointestinal_hemorrhage1.61885035
67MP0003786_premature_aging1.61568504
68MP0004043_abnormal_pH_regulation1.59971166
69MP0010155_abnormal_intestine_physiology1.59792572
70MP0002419_abnormal_innate_immunity1.58240270
71MP0002118_abnormal_lipid_homeostasis1.56562521
72MP0003186_abnormal_redox_activity1.56038136
73MP0000750_abnormal_muscle_regeneration1.55143661
74MP0005310_abnormal_salivary_gland1.51790134
75MP0002006_tumorigenesis1.50693843
76MP0008775_abnormal_heart_ventricle1.49395948
77MP0008260_abnormal_autophagy1.49077165
78MP0002148_abnormal_hypersensitivity_rea1.46536781
79MP0005266_abnormal_metabolism1.45512997
80MP0009643_abnormal_urine_homeostasis1.42962767
81MP0005385_cardiovascular_system_phenoty1.41443272
82MP0001544_abnormal_cardiovascular_syste1.41443272
83MP0001764_abnormal_homeostasis1.40644823
84MP0008995_early_reproductive_senescence1.39183276
85MP0010630_abnormal_cardiac_muscle1.39175315
86MP0002972_abnormal_cardiac_muscle1.37035418
87MP0000747_muscle_weakness1.34728734
88MP0003705_abnormal_hypodermis_morpholog1.34585441
89MP0003137_abnormal_impulse_conducting1.30768714
90MP0001845_abnormal_inflammatory_respons1.30425852
91MP0004019_abnormal_vitamin_homeostasis1.28224939
92MP0006138_congestive_heart_failure1.27927709
93MP0008058_abnormal_DNA_repair1.27385387
94MP0005584_abnormal_enzyme/coenzyme_acti1.26576165
95MP0004233_abnormal_muscle_weight1.26339343
96MP0003787_abnormal_imprinting1.25661113
97MP0002277_abnormal_respiratory_mucosa1.25615877
98MP0002971_abnormal_brown_adipose1.24414113
99MP0004185_abnormal_adipocyte_glucose1.21128516
100MP0005620_abnormal_muscle_contractility1.20166830
101MP0002019_abnormal_tumor_incidence1.19123991
102MP0008961_abnormal_basal_metabolism1.18539776
103MP0004947_skin_inflammation1.18470701
104MP0005464_abnormal_platelet_physiology1.15800268
105MP0000372_irregular_coat_pigmentation1.15502676
106MP0002106_abnormal_muscle_physiology1.14527710
107MP0000015_abnormal_ear_pigmentation1.10722635
108MP0002933_joint_inflammation1.10092136
109MP0003191_abnormal_cellular_cholesterol1.09468414
110MP0003693_abnormal_embryo_hatching1.07155565
111MP0001851_eye_inflammation1.07084016
112MP0002078_abnormal_glucose_homeostasis1.06316014
113MP0002163_abnormal_gland_morphology1.05916393
114MP0004957_abnormal_blastocyst_morpholog1.04497529
115MP0005375_adipose_tissue_phenotype1.04066081
116MP0001853_heart_inflammation1.01514038
117MP0000490_abnormal_crypts_of0.97397807
118MP0003656_abnormal_erythrocyte_physiolo0.96519813
119MP0000598_abnormal_liver_morphology0.95569764
120MP0005636_abnormal_mineral_homeostasis0.91108077
121MP0000759_abnormal_skeletal_muscle0.90275347
122MP0009697_abnormal_copulation0.89830633
123MP0003567_abnormal_fetal_cardiomyocyte0.89324434
124MP0003828_pulmonary_edema0.88631321
125MP0002332_abnormal_exercise_endurance0.87532438
126MP0001661_extended_life_span0.87076976
127MP0001730_embryonic_growth_arrest0.85449364
128MP0005369_muscle_phenotype0.85151070
129MP0003868_abnormal_feces_composition0.85046052
130MP0005376_homeostasis/metabolism_phenot0.84529445
131MP0004808_abnormal_hematopoietic_stem0.84206025
132MP0003300_gastrointestinal_ulcer0.82873245
133MP0006082_CNS_inflammation0.82565723
134MP0005451_abnormal_body_composition0.82435802
135MP0008469_abnormal_protein_level0.80616330
136MP0002127_abnormal_cardiovascular_syste0.80023001
137MP0002102_abnormal_ear_morphology0.79684982
138MP0004484_altered_response_of0.77714515
139MP0004147_increased_porphyrin_level0.77682115
140MP0005535_abnormal_body_temperature0.77636053
141MP0000358_abnormal_cell_content/0.77202507
142MP0001533_abnormal_skeleton_physiology0.77199927
143MP0004085_abnormal_heartbeat0.76568382
144MP0002138_abnormal_hepatobiliary_system0.76495554
145MP0003984_embryonic_growth_retardation0.75555426
146MP0002970_abnormal_white_adipose0.74905761
147MP0002088_abnormal_embryonic_growth/wei0.74289058
148MP0005408_hypopigmentation0.73717210
149MP0002095_abnormal_skin_pigmentation0.73705313
150MP0005379_endocrine/exocrine_gland_phen0.72530085
151MP0010094_abnormal_chromosome_stability0.72174295
152MP0001756_abnormal_urination0.71909689
153MP0003718_maternal_effect0.70191857
154MP0003111_abnormal_nucleus_morphology0.69242749
155MP0001986_abnormal_taste_sensitivity0.68946798
156MP0005334_abnormal_fat_pad0.68442601
157MP0005380_embryogenesis_phenotype0.68163039
158MP0001672_abnormal_embryogenesis/_devel0.68163039
159MP0009765_abnormal_xenobiotic_induced0.68141327
160MP0009672_abnormal_birth_weight0.67059407
161MP0000427_abnormal_hair_cycle0.65395091
162MP0009642_abnormal_blood_homeostasis0.64745916
163MP0004145_abnormal_muscle_electrophysio0.64325266
164MP0001929_abnormal_gametogenesis0.64031338
165MP0000313_abnormal_cell_death0.63510094
166MP0003077_abnormal_cell_cycle0.62363313
167MP0001663_abnormal_digestive_system0.61566510
168MP0009763_increased_sensitivity_to0.61560934
169MP0004142_abnormal_muscle_tone0.61537057
170MP0005174_abnormal_tail_pigmentation0.60580955
171MP0004883_abnormal_blood_vessel0.60544968
172MP0002132_abnormal_respiratory_system0.60103410
173MP0000266_abnormal_heart_morphology0.59677295
174MP0008873_increased_physiological_sensi0.58755781
175MP0002998_abnormal_bone_remodeling0.58126043
176MP0003950_abnormal_plasma_membrane0.56314429
177MP0001697_abnormal_embryo_size0.54414228
178MP0002080_prenatal_lethality0.54217896
179MP0005220_abnormal_exocrine_pancreas0.54209974
180MP0000230_abnormal_systemic_arterial0.50017977

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.12498149
2Abnormality of T cell number (HP:0011839)6.54181283
3Hypoglycemic coma (HP:0001325)5.01242006
4Hyperglycinuria (HP:0003108)4.93617154
5Abnormality of T cells (HP:0002843)4.81689230
6Hyperammonemia (HP:0001987)4.50270736
7Myoglobinuria (HP:0002913)4.48712617
8Severe combined immunodeficiency (HP:0004430)4.47114969
9Abnormality of serine family amino acid metabolism (HP:0010894)4.45572793
10Abnormality of glycine metabolism (HP:0010895)4.45572793
11Ketosis (HP:0001946)4.39208525
12Stomatitis (HP:0010280)4.36275054
13Abnormality of fatty-acid metabolism (HP:0004359)4.25433804
14Hyperglycinemia (HP:0002154)4.23472274
15Ketoacidosis (HP:0001993)4.20815618
16IgG deficiency (HP:0004315)4.20249645
17IgM deficiency (HP:0002850)4.19719013
18Intrahepatic cholestasis (HP:0001406)4.14892578
19Dicarboxylic aciduria (HP:0003215)4.06891102
20Abnormality of dicarboxylic acid metabolism (HP:0010995)4.06891102
21Rhabdomyolysis (HP:0003201)4.05900723
22Elevated erythrocyte sedimentation rate (HP:0003565)4.04770535
23Autoimmune hemolytic anemia (HP:0001890)4.01707251
24Abnormality of aromatic amino acid family metabolism (HP:0004338)3.88811025
25Cerebral edema (HP:0002181)3.87841637
26Combined immunodeficiency (HP:0005387)3.76379198
27Hepatic necrosis (HP:0002605)3.76343784
28Recurrent fungal infections (HP:0002841)3.72289248
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.65739994
30Panhypogammaglobulinemia (HP:0003139)3.61844079
31Hypobetalipoproteinemia (HP:0003563)3.61608858
32Abnormality of monocarboxylic acid metabolism (HP:0010996)3.59804514
33Pustule (HP:0200039)3.58951199
34Eczematoid dermatitis (HP:0000976)3.49050693
35Acute encephalopathy (HP:0006846)3.47162277
36Xanthomatosis (HP:0000991)3.42578586
37Abnormality of eosinophils (HP:0001879)3.42149631
38Recurrent cutaneous fungal infections (HP:0011370)3.37558026
39Chronic mucocutaneous candidiasis (HP:0002728)3.37558026
40Recurrent bacterial skin infections (HP:0005406)3.36589413
41Sudden death (HP:0001699)3.34288392
42Lethargy (HP:0001254)3.33093113
43Increased serum pyruvate (HP:0003542)3.30322634
44Abnormality of glycolysis (HP:0004366)3.30322634
45Abnormality of serum amino acid levels (HP:0003112)3.26998645
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26540974
47Deep venous thrombosis (HP:0002625)3.26411923
48Palpitations (HP:0001962)3.25167263
49Exercise-induced muscle cramps (HP:0003710)3.24274927
50Generalized aminoaciduria (HP:0002909)3.22879105
51Thyroiditis (HP:0100646)3.19413422
52Abnormality of T cell physiology (HP:0011840)3.16884259
53Abnormal mitochondria in muscle tissue (HP:0008316)3.16200318
54Myositis (HP:0100614)3.16140793
55Hypoplasia of the thymus (HP:0000778)3.15956939
56IgA deficiency (HP:0002720)3.15432261
57Metabolic acidosis (HP:0001942)3.13715973
58Gout (HP:0001997)3.12623030
59Hypolipoproteinemia (HP:0010981)3.12288452
60Recurrent viral infections (HP:0004429)3.10893197
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.10664932
62Ventricular tachycardia (HP:0004756)3.10234815
63Leukocytosis (HP:0001974)3.04551778
64Acute necrotizing encephalopathy (HP:0006965)3.00689317
65Eosinophilia (HP:0001880)2.97297938
66Hepatocellular necrosis (HP:0001404)2.97202622
67Proximal tubulopathy (HP:0000114)2.94740894
68Lactic acidosis (HP:0003128)2.94316937
69Hypoalphalipoproteinemia (HP:0003233)2.93966282
70Encephalitis (HP:0002383)2.91201263
71Abnormality of aspartate family amino acid metabolism (HP:0010899)2.89724411
72Lymphopenia (HP:0001888)2.88950341
73Recurrent abscess formation (HP:0002722)2.88389387
74Increased muscle lipid content (HP:0009058)2.86150977
75Granulocytopenia (HP:0001913)2.85579792
76Hyperinsulinemic hypoglycemia (HP:0000825)2.84444104
77Exercise-induced myalgia (HP:0003738)2.83927056
78Ragged-red muscle fibers (HP:0003200)2.83245079
79Optic neuritis (HP:0100653)2.81017872
80Retrobulbar optic neuritis (HP:0100654)2.81017872
81Abnormality of glutamine family amino acid metabolism (HP:0010902)2.79220105
82Hyperlipoproteinemia (HP:0010980)2.78786626
83Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.76385338
84Nausea (HP:0002018)2.76240812
85Recurrent bronchitis (HP:0002837)2.71335445
86Increased CSF lactate (HP:0002490)2.70548471
87Abnormality of sulfur amino acid metabolism (HP:0004339)2.67897694
88Abnormality of cells of the lymphoid lineage (HP:0012140)2.66813886
89Increased IgM level (HP:0003496)2.61817291
90Basal cell carcinoma (HP:0002671)2.61509117
91Muscle fiber splitting (HP:0003555)2.60620387
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59923719
93Abnormality of alanine metabolism (HP:0010916)2.59923719
94Hyperalaninemia (HP:0003348)2.59923719
95Abnormality of purine metabolism (HP:0004352)2.59112045
96Recurrent skin infections (HP:0001581)2.57027849
97Hyperuricemia (HP:0002149)2.56757198
98Increased purine levels (HP:0004368)2.56757198
99Gastrointestinal infarctions (HP:0005244)2.54933592
100Lymphoma (HP:0002665)2.53972086
101Vomiting (HP:0002013)2.53624909
102Lipoatrophy (HP:0100578)2.50851388
103Stomach cancer (HP:0012126)2.48988438
104Abnormality of methionine metabolism (HP:0010901)2.47322066
105Abnormality of nucleobase metabolism (HP:0010932)2.46632462
106Right ventricular cardiomyopathy (HP:0011663)2.44232868
107Mitochondrial inheritance (HP:0001427)2.44051493
108Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43597899
109Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43597899
110Delayed CNS myelination (HP:0002188)2.41130004
111Dilated cardiomyopathy (HP:0001644)2.40565016
112Aplastic anemia (HP:0001915)2.40340492
113Progressive macrocephaly (HP:0004481)2.40181368
114Keratoconjunctivitis sicca (HP:0001097)2.38944072
115Multiple enchondromatosis (HP:0005701)2.38586207
116Abnormality of the fingertips (HP:0001211)2.38046282
117Abnormality of chromosome stability (HP:0003220)2.37491837
118Acute hepatic failure (HP:0006554)2.37312025
119Meningitis (HP:0001287)2.36756806
120Keratoconjunctivitis (HP:0001096)2.36666994
121Calf muscle hypertrophy (HP:0008981)2.36580538
122Increased serum lactate (HP:0002151)2.35954353
123Inflammation of the large intestine (HP:0002037)2.35336709
124Abnormality of B cell number (HP:0010975)2.34787707
125Vasculitis (HP:0002633)2.34491082
126Hyperbilirubinemia (HP:0002904)2.34049957
127Abnormal gallbladder morphology (HP:0012437)2.33921940
128Cholelithiasis (HP:0001081)2.32990487
129Increased intramyocellular lipid droplets (HP:0012240)2.32504086
130Hypoglycemic seizures (HP:0002173)2.32347497
131Colitis (HP:0002583)2.32007585
132Mediastinal lymphadenopathy (HP:0100721)2.30641277
133Atrioventricular block (HP:0001678)2.30209185
134Prolonged partial thromboplastin time (HP:0003645)2.29388413
135Hyperglycemia (HP:0003074)2.28348023
136CNS demyelination (HP:0007305)2.25622500
137Chronic diarrhea (HP:0002028)2.25441683
138Epidermoid cyst (HP:0200040)2.25014552
139Respiratory failure (HP:0002878)2.23144221
140Abnormal spermatogenesis (HP:0008669)2.22936458
141Orchitis (HP:0100796)2.22874593
142Abnormality of pyrimidine metabolism (HP:0004353)2.21673295
143Methylmalonic aciduria (HP:0012120)2.19849176
144Late onset (HP:0003584)2.19311857
145Abnormality of urine glucose concentration (HP:0011016)2.17917291
146Glycosuria (HP:0003076)2.17917291
147Gastrointestinal inflammation (HP:0004386)2.15603821
148Spastic diplegia (HP:0001264)2.11277896
149Atrial fibrillation (HP:0005110)2.10577181
150Renal cortical cysts (HP:0000803)2.09615206
151Autoimmune thrombocytopenia (HP:0001973)2.09447089
152Chronic obstructive pulmonary disease (HP:0006510)2.08672359
153Obstructive lung disease (HP:0006536)2.08672359
154Exercise intolerance (HP:0003546)2.07812732
155Muscle hypertrophy of the lower extremities (HP:0008968)2.07006513
156Progressive muscle weakness (HP:0003323)2.06955913
157Hyporeflexia of lower limbs (HP:0002600)2.05474755
158Complement deficiency (HP:0004431)2.05103521
159Skin nodule (HP:0200036)2.04699089
160Periodontitis (HP:0000704)2.02942777
161Abnormal cartilage morphology (HP:0002763)2.02821678
162Fat malabsorption (HP:0002630)2.02284629
163Cellular immunodeficiency (HP:0005374)2.01973229
164Verrucae (HP:0200043)2.00981084
165Papilloma (HP:0012740)2.00981084
166Slow saccadic eye movements (HP:0000514)1.98929625
167Aplasia/Hypoplasia of the thymus (HP:0010515)1.95555054
168Anorexia (HP:0002039)1.95532876
169Abnormal hair whorl (HP:0010721)1.90092156
170Lipid accumulation in hepatocytes (HP:0006561)1.87551920
171Hemoptysis (HP:0002105)1.87326713
172Chest pain (HP:0100749)1.85953823
173Hypochromic microcytic anemia (HP:0004840)1.84978377
1743-Methylglutaconic aciduria (HP:0003535)1.82295558
175Neutropenia (HP:0001875)1.82149066
176Myelodysplasia (HP:0002863)1.77597583
177Prolonged bleeding time (HP:0003010)1.77250420
178Fatigue (HP:0012378)1.77234499
179Abnormality of DNA repair (HP:0003254)1.75503578
180Spontaneous hematomas (HP:0007420)1.75127007
181B lymphocytopenia (HP:0010976)1.73351794
182Clubbing of toes (HP:0100760)1.70788591
183Respiratory difficulties (HP:0002880)1.70223483
184Prominent nose (HP:0000448)1.69160270
185Papillary thyroid carcinoma (HP:0002895)1.68522133
186Gingival bleeding (HP:0000225)1.67671062
187Bronchitis (HP:0012387)1.66067908
188Abnormality of the prostate (HP:0008775)1.65349062
189Keratitis (HP:0000491)1.65108577
190Joint swelling (HP:0001386)1.65105075
191Volvulus (HP:0002580)1.61125176
192Pulmonary infiltrates (HP:0002113)1.58239837
193Agammaglobulinemia (HP:0004432)1.56603939
194Epistaxis (HP:0000421)1.56428385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.67849634
2BCKDK5.65077533
3PDK34.50673802
4PDK44.50673802
5MAP4K14.11584332
6NEK13.74183321
7PKN23.48326393
8TAOK33.20406752
9TTN3.14263741
10TRIB32.84570844
11PDK22.79337124
12CAMKK22.67786276
13GRK62.58624208
14ITK2.46132494
15IKBKE2.29406297
16NLK2.26781389
17LMTK22.06658715
18BTK2.01961806
19TEC1.98643303
20TYK21.97728930
21MYLK1.95555094
22FLT31.92334401
23STK38L1.86770258
24EIF2AK11.86371709
25OBSCN1.84517880
26WEE11.81811157
27BUB11.78187020
28JAK31.77810955
29FES1.74892699
30SYK1.74761049
31MARK31.67880777
32PHKG11.67562297
33PHKG21.67562297
34LCK1.63106093
35ZAP701.62560479
36RIPK41.61995870
37NME21.59132864
38PIK3CG1.58613400
39SIK11.51063087
40JAK11.45446834
41PIM11.43396780
42TTK1.41692122
43BLK1.39571316
44CSK1.35653304
45EPHA21.35623883
46NUAK11.34345838
47WNK41.29506947
48MAP3K141.29249319
49HCK1.27798502
50PINK11.20978352
51MUSK1.19453722
52TSSK61.19008215
53BRD41.13793816
54PRKCQ1.13618707
55CDK41.11661143
56ERN11.10573310
57LYN1.07422558
58LATS11.06948974
59NEK21.04898679
60ERBB41.03807076
61ACVR1B1.03615747
62CDC71.02749443
63SRPK11.01065744
64CAMKK10.99656479
65KDR0.95999815
66EIF2AK30.95973586
67MAP3K130.94884871
68MAPK110.92197484
69IKBKB0.91950387
70CLK10.91942548
71SIK30.91926856
72SGK20.91459850
73FGFR40.90971123
74PRKAA10.90759793
75FGFR30.90731438
76NEK90.87921404
77TNIK0.86831296
78ZAK0.86616351
79MST40.85668036
80BRSK20.85415363
81STK40.83412612
82IRAK40.83191835
83PASK0.83155958
84ILK0.81948808
85INSRR0.79250889
86WNK30.78539226
87STK240.78238399
88SCYL20.78178941
89TLK10.77245860
90PAK30.76775273
91CCNB10.73030232
92MELK0.72998414
93NEK60.70965357
94PRKAA20.69941731
95DYRK30.68605357
96MAPKAPK30.67599456
97FGR0.67358899
98CAMK40.67115512
99PTK60.66924791
100RPS6KB20.66192703
101CDK120.65290672
102AURKB0.65042888
103PLK10.63985391
104PAK40.61818416
105EEF2K0.61019154
106PRPF4B0.60540462
107FRK0.57114418
108MAP3K100.56535830
109ABL20.56352488
110RAF10.56035260
111LRRK20.55366000
112MAP3K50.55347971
113PIK3CA0.55211280
114TESK20.55183746
115MAP3K80.54386514
116AKT20.53692330
117SIK20.53356642
118CSF1R0.53122292
119MTOR0.53085679
120TBK10.52822841
121BMPR20.49812168
122PDK10.49607008
123STK30.48857393
124CDK60.48621976
125AURKA0.48511606
126MAP2K20.47269185
127NME10.47016610
128STK160.46708702
129EGFR0.45977250
130MAP2K30.45600310
131SGK30.43629639
132GRK50.43027171
133RPS6KA50.42691069
134WNK10.42090401
135ERBB30.42071218
136PLK40.41404516
137TIE10.41240280
138BRSK10.40775138
139MAP4K20.39825984
140VRK10.39691746
141MAP3K30.39079700
142MAP3K70.38401315
143CHUK0.38286270
144LATS20.37248129
145PRKACG0.37231058
146MAPK120.36723424
147DAPK30.36236181
148ATM0.35734246
149DYRK1B0.34729357
150CSNK2A20.33916025
151BMPR1B0.33599165
152YES10.33239045
153ATR0.33059040
154SGK4940.32744118
155SGK2230.32744118
156SGK10.32468375
157FGFR10.32413856
158EPHA30.31154002
159ICK0.30678132
160CDK70.30617914
161PRKCI0.30429622
162CAMK2D0.30330059
163STK100.30081784
164CHEK10.29999190
165TRIM280.29965399
166PRKD10.29302977
167STK380.28032913
168MET0.27685915
169PRKACB0.27309082
170AKT30.25392248
171JAK20.24955249
172DMPK0.24947840

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.26978477
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.97797423
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.58427013
4T cell receptor signaling pathway_Homo sapiens_hsa046603.45692032
5Propanoate metabolism_Homo sapiens_hsa006403.30187776
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26891806
7Fatty acid degradation_Homo sapiens_hsa000713.14033235
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.13513914
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.00237377
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.96542768
11Carbon metabolism_Homo sapiens_hsa012002.50116651
12Measles_Homo sapiens_hsa051622.48018675
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.42144266
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.40262241
15Fatty acid metabolism_Homo sapiens_hsa012122.37255260
16Pyruvate metabolism_Homo sapiens_hsa006202.33388453
17Butanoate metabolism_Homo sapiens_hsa006502.21836530
18Graft-versus-host disease_Homo sapiens_hsa053322.16251920
19Tryptophan metabolism_Homo sapiens_hsa003802.13233947
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.11625175
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.06750883
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.06484751
23Arginine biosynthesis_Homo sapiens_hsa002202.05445819
24Autoimmune thyroid disease_Homo sapiens_hsa053201.99808224
25Biosynthesis of amino acids_Homo sapiens_hsa012301.98770918
26Nitrogen metabolism_Homo sapiens_hsa009101.94689827
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.93408428
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90403653
29Hematopoietic cell lineage_Homo sapiens_hsa046401.89992476
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.88787022
31Allograft rejection_Homo sapiens_hsa053301.86383894
32B cell receptor signaling pathway_Homo sapiens_hsa046621.84891601
33Antigen processing and presentation_Homo sapiens_hsa046121.76396730
34Peroxisome_Homo sapiens_hsa041461.75867324
35PPAR signaling pathway_Homo sapiens_hsa033201.71891176
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.70337802
37Osteoclast differentiation_Homo sapiens_hsa043801.66620784
38Selenocompound metabolism_Homo sapiens_hsa004501.66500218
39beta-Alanine metabolism_Homo sapiens_hsa004101.61208327
40Herpes simplex infection_Homo sapiens_hsa051681.57854714
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57722836
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57494661
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.53416309
44Acute myeloid leukemia_Homo sapiens_hsa052211.52772967
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52171562
46Fanconi anemia pathway_Homo sapiens_hsa034601.51211029
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48802826
48One carbon pool by folate_Homo sapiens_hsa006701.43165149
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42453864
50Fatty acid elongation_Homo sapiens_hsa000621.40676071
51Leishmaniasis_Homo sapiens_hsa051401.38483046
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.35744885
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34520642
54Homologous recombination_Homo sapiens_hsa034401.33078148
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31646076
56Parkinsons disease_Homo sapiens_hsa050121.30444452
57Oxidative phosphorylation_Homo sapiens_hsa001901.29580264
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.26199997
59Viral myocarditis_Homo sapiens_hsa054161.20774572
60Cyanoamino acid metabolism_Homo sapiens_hsa004601.20343280
61Epstein-Barr virus infection_Homo sapiens_hsa051691.19794387
62Viral carcinogenesis_Homo sapiens_hsa052031.18448730
63Phenylalanine metabolism_Homo sapiens_hsa003601.18188139
64Non-small cell lung cancer_Homo sapiens_hsa052231.16720141
65Starch and sucrose metabolism_Homo sapiens_hsa005001.16498058
66Folate biosynthesis_Homo sapiens_hsa007901.14160459
67Cell cycle_Homo sapiens_hsa041101.10994981
68Pentose phosphate pathway_Homo sapiens_hsa000301.10796712
69mRNA surveillance pathway_Homo sapiens_hsa030151.10402097
70Arginine and proline metabolism_Homo sapiens_hsa003301.10093156
71Non-homologous end-joining_Homo sapiens_hsa034501.08634858
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08621016
73Hepatitis B_Homo sapiens_hsa051611.07050448
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06637494
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06276519
76Type I diabetes mellitus_Homo sapiens_hsa049401.04724682
77Sulfur metabolism_Homo sapiens_hsa009201.02102350
78Apoptosis_Homo sapiens_hsa042100.99751538
79Sulfur relay system_Homo sapiens_hsa041220.99303407
80Fat digestion and absorption_Homo sapiens_hsa049750.97930590
81Vitamin B6 metabolism_Homo sapiens_hsa007500.97265109
82Complement and coagulation cascades_Homo sapiens_hsa046100.96830282
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96410383
84Basal transcription factors_Homo sapiens_hsa030220.96154803
85Chemokine signaling pathway_Homo sapiens_hsa040620.95642733
86Thyroid cancer_Homo sapiens_hsa052160.94554590
87Colorectal cancer_Homo sapiens_hsa052100.93975221
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92488713
89FoxO signaling pathway_Homo sapiens_hsa040680.91398248
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91164657
91Glutathione metabolism_Homo sapiens_hsa004800.90899301
92Inositol phosphate metabolism_Homo sapiens_hsa005620.90126303
93Legionellosis_Homo sapiens_hsa051340.90102338
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89718046
95Lysine degradation_Homo sapiens_hsa003100.89596547
96Tyrosine metabolism_Homo sapiens_hsa003500.89565936
97Circadian rhythm_Homo sapiens_hsa047100.89067216
98Chemical carcinogenesis_Homo sapiens_hsa052040.87183266
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86678750
100Fructose and mannose metabolism_Homo sapiens_hsa000510.86570440
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86562566
102Huntingtons disease_Homo sapiens_hsa050160.85966221
103Cardiac muscle contraction_Homo sapiens_hsa042600.85134736
104Influenza A_Homo sapiens_hsa051640.84377530
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82821331
106HTLV-I infection_Homo sapiens_hsa051660.82151171
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81072844
108Histidine metabolism_Homo sapiens_hsa003400.81072038
109Proteasome_Homo sapiens_hsa030500.75997837
110Caffeine metabolism_Homo sapiens_hsa002320.75164675
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74299905
112TNF signaling pathway_Homo sapiens_hsa046680.73521940
113Bile secretion_Homo sapiens_hsa049760.73376575
114Retinol metabolism_Homo sapiens_hsa008300.71004088
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70436183
116Alzheimers disease_Homo sapiens_hsa050100.70376118
117Metabolic pathways_Homo sapiens_hsa011000.69858330
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.68455109
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68146603
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.67901168
121Fatty acid biosynthesis_Homo sapiens_hsa000610.66662439
122Tuberculosis_Homo sapiens_hsa051520.66551344
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66492952
124Regulation of autophagy_Homo sapiens_hsa041400.65989500
125DNA replication_Homo sapiens_hsa030300.65759745
126Platelet activation_Homo sapiens_hsa046110.64712897
127Hepatitis C_Homo sapiens_hsa051600.63947878
128p53 signaling pathway_Homo sapiens_hsa041150.63616966
129Glycerolipid metabolism_Homo sapiens_hsa005610.62797406
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62104808
131Pyrimidine metabolism_Homo sapiens_hsa002400.61313514
132Toxoplasmosis_Homo sapiens_hsa051450.57172488
133Galactose metabolism_Homo sapiens_hsa000520.54123911
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.53080835
135Pancreatic cancer_Homo sapiens_hsa052120.52784346
136Mismatch repair_Homo sapiens_hsa034300.52013754
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50815221
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50656704
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49008399
140Vitamin digestion and absorption_Homo sapiens_hsa049770.48877715
141Glucagon signaling pathway_Homo sapiens_hsa049220.47793329
142RNA transport_Homo sapiens_hsa030130.45813866
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45630402
144Endometrial cancer_Homo sapiens_hsa052130.44602613
145RNA polymerase_Homo sapiens_hsa030200.44084526
146Malaria_Homo sapiens_hsa051440.44051456
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.42645605
148Insulin resistance_Homo sapiens_hsa049310.42450837
149ABC transporters_Homo sapiens_hsa020100.41588421
150Prostate cancer_Homo sapiens_hsa052150.37293416
151AMPK signaling pathway_Homo sapiens_hsa041520.36224505
152Prolactin signaling pathway_Homo sapiens_hsa049170.36214342
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33513248
154Oocyte meiosis_Homo sapiens_hsa041140.31909489
155Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31155742
156Nucleotide excision repair_Homo sapiens_hsa034200.28344264
157Neurotrophin signaling pathway_Homo sapiens_hsa047220.25349946
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24100541
159Dilated cardiomyopathy_Homo sapiens_hsa054140.23987003
160Purine metabolism_Homo sapiens_hsa002300.23536443
161Ribosome_Homo sapiens_hsa030100.22910368
162Insulin signaling pathway_Homo sapiens_hsa049100.21256768
163Systemic lupus erythematosus_Homo sapiens_hsa053220.19484067
164Base excision repair_Homo sapiens_hsa034100.17910733
165Spliceosome_Homo sapiens_hsa030400.17157782
166Central carbon metabolism in cancer_Homo sapiens_hsa052300.16279163
167Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15193355
168Staphylococcus aureus infection_Homo sapiens_hsa051500.15184219
169Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14441751
170RNA degradation_Homo sapiens_hsa030180.11708377

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