OXR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.61183052
2synaptic vesicle exocytosis (GO:0016079)5.54047138
3glutamate secretion (GO:0014047)5.45457265
4regulation of synaptic vesicle exocytosis (GO:2000300)5.32577752
5neuronal action potential propagation (GO:0019227)5.28725854
6synaptic vesicle maturation (GO:0016188)5.22785947
7locomotory exploration behavior (GO:0035641)5.10391470
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.08076859
9vocalization behavior (GO:0071625)5.02201475
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.90870967
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.77367661
12regulation of synaptic vesicle transport (GO:1902803)4.69260107
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.65070318
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.56984378
15regulation of glutamate receptor signaling pathway (GO:1900449)4.50337072
16neurotransmitter secretion (GO:0007269)4.46278282
17protein localization to synapse (GO:0035418)4.38997089
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.30477391
19neuron cell-cell adhesion (GO:0007158)4.01778580
20synaptic transmission, glutamatergic (GO:0035249)4.00992099
21neuron-neuron synaptic transmission (GO:0007270)4.00822877
22gamma-aminobutyric acid signaling pathway (GO:0007214)3.99396651
23glutamate receptor signaling pathway (GO:0007215)3.92757241
24exploration behavior (GO:0035640)3.87165321
25neurotransmitter-gated ion channel clustering (GO:0072578)3.81399228
26gamma-aminobutyric acid transport (GO:0015812)3.80178460
27cellular potassium ion homeostasis (GO:0030007)3.74038614
28regulation of neuronal synaptic plasticity (GO:0048168)3.73744208
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.71449207
30positive regulation of dendritic spine morphogenesis (GO:0061003)3.65460124
31neurotransmitter uptake (GO:0001504)3.65003041
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.63845613
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61413807
34neurotransmitter transport (GO:0006836)3.59067289
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.52288141
36long-term synaptic potentiation (GO:0060291)3.50983599
37long-term memory (GO:0007616)3.50691513
38proline transport (GO:0015824)3.49537769
39activation of protein kinase A activity (GO:0034199)3.47047380
40regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.44177733
41regulation of dendritic spine development (GO:0060998)3.43242280
42regulation of neurotransmitter secretion (GO:0046928)3.39051016
43cerebellar Purkinje cell differentiation (GO:0021702)3.37358301
44positive regulation of membrane potential (GO:0045838)3.35806358
45regulation of postsynaptic membrane potential (GO:0060078)3.33592495
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.33009493
47presynaptic membrane assembly (GO:0097105)3.32113862
48regulation of neurotransmitter levels (GO:0001505)3.31582362
49C4-dicarboxylate transport (GO:0015740)3.28348675
50regulation of synaptic plasticity (GO:0048167)3.23040210
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22307517
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.21793087
53regulation of vesicle fusion (GO:0031338)3.21077095
54synaptic vesicle endocytosis (GO:0048488)3.20132888
55L-amino acid import (GO:0043092)3.19891010
56regulation of cell communication by electrical coupling (GO:0010649)3.18664363
57regulation of synapse structural plasticity (GO:0051823)3.17864433
58auditory behavior (GO:0031223)3.17779806
59layer formation in cerebral cortex (GO:0021819)3.15432510
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.14506426
61potassium ion import (GO:0010107)3.12508199
62dendritic spine organization (GO:0097061)3.11888566
63righting reflex (GO:0060013)3.11429274
64membrane depolarization during action potential (GO:0086010)3.10341996
65heart field specification (GO:0003128)3.09533438
66secondary heart field specification (GO:0003139)3.09533438
67neuromuscular process controlling posture (GO:0050884)3.09041203
68regulation of neurotransmitter transport (GO:0051588)3.08654255
69detection of calcium ion (GO:0005513)3.08579916
70presynaptic membrane organization (GO:0097090)3.08444136
71cerebellar granule cell differentiation (GO:0021707)3.07486884
72vesicle transport along microtubule (GO:0047496)3.05353675
73neuron recognition (GO:0008038)3.02946774
74central nervous system projection neuron axonogenesis (GO:0021952)3.01965648
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00981680
76postsynaptic membrane organization (GO:0001941)3.00168445
77regulation of voltage-gated calcium channel activity (GO:1901385)2.99535879
78sodium ion export (GO:0071436)2.99413122
79membrane depolarization (GO:0051899)2.98682204
80response to histamine (GO:0034776)2.97573380
81calcium ion-dependent exocytosis (GO:0017156)2.97031652
82positive regulation of synapse maturation (GO:0090129)2.96331693
83transmission of nerve impulse (GO:0019226)2.96281248
84serotonin metabolic process (GO:0042428)2.95605161
85synaptic transmission (GO:0007268)2.94789719
86cellular sodium ion homeostasis (GO:0006883)2.94567907
87positive regulation of vesicle fusion (GO:0031340)2.94130343
88glial cell proliferation (GO:0014009)2.93508686
89negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93118585
90acidic amino acid transport (GO:0015800)2.91177851
91response to insecticide (GO:0017085)2.89851953
92negative regulation of dendrite development (GO:2000171)2.89256336
93innervation (GO:0060384)2.88520945
94positive regulation of dendritic spine development (GO:0060999)2.87921898
95retinal cone cell development (GO:0046549)2.87377659
96regulation of dendritic spine morphogenesis (GO:0061001)2.87032246
97positive regulation of synaptic transmission (GO:0050806)2.84676291
98negative regulation of dendrite morphogenesis (GO:0050774)2.84612539
99amino acid import (GO:0043090)2.82455451
100positive regulation of neurotransmitter transport (GO:0051590)2.81866440
101positive regulation of neurotransmitter secretion (GO:0001956)2.81361155
102regulation of synaptic transmission (GO:0050804)2.81197246
103negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80450747
104cell communication by electrical coupling (GO:0010644)2.80085046
105neuronal ion channel clustering (GO:0045161)2.79449930
106dendritic spine morphogenesis (GO:0060997)2.78781277
107protein localization to cilium (GO:0061512)2.78502460
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78091805
109mating behavior (GO:0007617)2.77632185
110positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75328724
111long term synaptic depression (GO:0060292)2.74974919
112potassium ion homeostasis (GO:0055075)2.73867482
113neuromuscular synaptic transmission (GO:0007274)2.72906650
114regulation of clathrin-mediated endocytosis (GO:2000369)2.72543785
115neuromuscular process controlling balance (GO:0050885)2.71846749
116primary amino compound metabolic process (GO:1901160)2.69883522
117positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.69676285
118learning (GO:0007612)2.69021595
119vesicle docking (GO:0048278)2.67492800
120membrane hyperpolarization (GO:0060081)2.65812095
121synaptic vesicle transport (GO:0048489)2.65733598
122establishment of synaptic vesicle localization (GO:0097480)2.65733598
123axonal fasciculation (GO:0007413)2.65557340
124cerebral cortex radially oriented cell migration (GO:0021799)2.65122797
125mechanosensory behavior (GO:0007638)2.64601507
126regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63901820
127regulation of exocytosis (GO:0017157)2.63417887
128synapse assembly (GO:0007416)2.62478928
129synapse organization (GO:0050808)2.62212856
130organelle transport along microtubule (GO:0072384)2.61821592
131positive regulation of exocytosis (GO:0045921)2.61559102
132positive regulation of synaptic transmission, GABAergic (GO:0032230)2.60891236
133negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60673974
134startle response (GO:0001964)2.60603718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.46398954
2GBX2_23144817_ChIP-Seq_PC3_Human3.80798416
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92332222
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85143683
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61569032
6TAF15_26573619_Chip-Seq_HEK293_Human2.57275056
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.47475833
8REST_21632747_ChIP-Seq_MESCs_Mouse2.43427426
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42781627
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41711979
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41711979
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37518410
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34118428
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28579475
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28187063
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24325483
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.19321330
18DROSHA_22980978_ChIP-Seq_HELA_Human2.18485520
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.00899039
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.99332441
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95730342
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.94963921
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91433585
24* SMAD4_21799915_ChIP-Seq_A2780_Human1.90353236
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88941975
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88616078
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86581488
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.85362101
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.85211490
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84957980
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.82795892
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78412057
33EWS_26573619_Chip-Seq_HEK293_Human1.76414400
34VDR_22108803_ChIP-Seq_LS180_Human1.65148606
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64574214
36* P300_19829295_ChIP-Seq_ESCs_Human1.61152841
37AR_21572438_ChIP-Seq_LNCaP_Human1.60846262
38* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60486041
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56593525
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.53265649
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52272061
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.52078068
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50908726
44RNF2_27304074_Chip-Seq_NSC_Mouse1.50810494
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49917843
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48046240
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.46321264
48ZNF274_21170338_ChIP-Seq_K562_Hela1.46213372
49AR_25329375_ChIP-Seq_VCAP_Human1.43603483
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43004372
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.41905202
52* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41514197
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40670176
54TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40164112
55* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39654604
56STAT3_23295773_ChIP-Seq_U87_Human1.38003779
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35868805
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.35290145
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34765602
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33899800
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32265502
62* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31204114
63* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30707641
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30117729
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.29308154
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.28572015
67P53_22387025_ChIP-Seq_ESCs_Mouse1.28237217
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27756182
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27732844
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27506079
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26870579
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.24912832
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24891915
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24534163
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24534163
76FUS_26573619_Chip-Seq_HEK293_Human1.23990264
77* TCF4_23295773_ChIP-Seq_U87_Human1.22739991
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.22275583
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22203824
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21205615
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20846042
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20070893
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.19209394
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.17287707
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17193114
86* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17035118
87TP53_16413492_ChIP-PET_HCT116_Human1.16913919
88* TCF4_22108803_ChIP-Seq_LS180_Human1.16346700
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16298435
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16209479
91AHR_22903824_ChIP-Seq_MCF-7_Human1.16174857
92BCAT_22108803_ChIP-Seq_LS180_Human1.15592884
93AR_19668381_ChIP-Seq_PC3_Human1.14273734
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13572083
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13106486
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09732066
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09144089
98ER_23166858_ChIP-Seq_MCF-7_Human1.08502720
99* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08353411
100GATA1_22025678_ChIP-Seq_K562_Human1.08018046
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06831092
102* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06236615
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05914451
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05683511
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05359783
106RUNX2_22187159_ChIP-Seq_PCA_Human1.03311884
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02983205
108TP53_18474530_ChIP-ChIP_U2OS_Human1.02075652
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.02058465
110IGF1R_20145208_ChIP-Seq_DFB_Human1.01483793
111* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99697134
112* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98983334
113* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98983334
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.98930627
115CBX2_27304074_Chip-Seq_ESCs_Mouse0.98502720
116NANOG_18555785_Chip-Seq_ESCs_Mouse0.97681504
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97653181
118FLI1_21867929_ChIP-Seq_TH2_Mouse0.96776392
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96638948
120P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96450556
121CBP_20019798_ChIP-Seq_JUKART_Human0.96079899
122IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96079899
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95583063
124JUN_21703547_ChIP-Seq_K562_Human0.95559504
125* EP300_21415370_ChIP-Seq_HL-1_Mouse0.93758268
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93542785
127RXR_22108803_ChIP-Seq_LS180_Human0.93280513
128KDM2B_26808549_Chip-Seq_REH_Human0.92430429
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91998441
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90349264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.87284603
2MP0003880_abnormal_central_pattern4.79193077
3MP0003635_abnormal_synaptic_transmissio4.03344544
4MP0004270_analgesia3.53562654
5MP0009046_muscle_twitch3.45212373
6MP0009745_abnormal_behavioral_response3.43163163
7MP0002064_seizures3.29704502
8MP0001968_abnormal_touch/_nociception3.10949308
9MP0002063_abnormal_learning/memory/cond3.08106278
10MP0001986_abnormal_taste_sensitivity2.85530271
11MP0002272_abnormal_nervous_system2.80990958
12MP0002572_abnormal_emotion/affect_behav2.68251059
13MP0001501_abnormal_sleep_pattern2.67744780
14MP0002734_abnormal_mechanical_nocicepti2.47838089
15MP0002736_abnormal_nociception_after2.47684830
16MP0003183_abnormal_peptide_metabolism2.37112009
17MP0001486_abnormal_startle_reflex2.29751399
18MP0009780_abnormal_chondrocyte_physiolo2.23540083
19MP0002735_abnormal_chemical_nociception2.21227747
20MP0002067_abnormal_sensory_capabilities2.10983476
21MP0002822_catalepsy2.04941322
22MP0003329_amyloid_beta_deposits2.02682162
23MP0008569_lethality_at_weaning1.99826388
24MP0001440_abnormal_grooming_behavior1.94791967
25MP0002909_abnormal_adrenal_gland1.94238432
26MP0002733_abnormal_thermal_nociception1.87314743
27MP0005423_abnormal_somatic_nervous1.86892249
28MP0002837_dystrophic_cardiac_calcinosis1.78340729
29MP0001970_abnormal_pain_threshold1.77773986
30MP0005646_abnormal_pituitary_gland1.71805258
31MP0003879_abnormal_hair_cell1.64006001
32MP0004924_abnormal_behavior1.62338474
33MP0005386_behavior/neurological_phenoty1.62338474
34MP0001984_abnormal_olfaction1.61103692
35MP0008877_abnormal_DNA_methylation1.60404251
36MP0002184_abnormal_innervation1.58411434
37MP0004811_abnormal_neuron_physiology1.57379041
38MP0003633_abnormal_nervous_system1.56118015
39MP0000013_abnormal_adipose_tissue1.52924422
40MP0002557_abnormal_social/conspecific_i1.50872540
41MP0004858_abnormal_nervous_system1.49297146
42MP0004142_abnormal_muscle_tone1.47140501
43MP0000955_abnormal_spinal_cord1.40952976
44MP0005187_abnormal_penis_morphology1.39672385
45MP0006276_abnormal_autonomic_nervous1.39581168
46MP0002066_abnormal_motor_capabilities/c1.37127780
47MP0000427_abnormal_hair_cycle1.36387945
48MP0008057_abnormal_DNA_replication1.35392322
49MP0002638_abnormal_pupillary_reflex1.35269619
50MP0003631_nervous_system_phenotype1.29055310
51MP0003787_abnormal_imprinting1.28626619
52MP0002009_preneoplasia1.25877338
53MP0000778_abnormal_nervous_system1.24893553
54MP0002882_abnormal_neuron_morphology1.24462997
55MP0005253_abnormal_eye_physiology1.22015390
56MP0010678_abnormal_skin_adnexa1.21537304
57MP0001502_abnormal_circadian_rhythm1.18944147
58MP0000751_myopathy1.14696562
59MP0002229_neurodegeneration1.12428870
60MP0010386_abnormal_urinary_bladder1.11886064
61MP0004145_abnormal_muscle_electrophysio1.09522941
62MP0005551_abnormal_eye_electrophysiolog1.08586714
63MP0000383_abnormal_hair_follicle1.07126583
64MP0001905_abnormal_dopamine_level1.04605528
65MP0003121_genomic_imprinting1.03778198
66MP0002102_abnormal_ear_morphology1.01299086
67MP0008874_decreased_physiological_sensi1.00002086
68MP0001188_hyperpigmentation0.99509888
69MP0000647_abnormal_sebaceous_gland0.99142070
70MP0000604_amyloidosis0.97995422
71MP0005623_abnormal_meninges_morphology0.97964035
72MP0003690_abnormal_glial_cell0.95385781
73MP0006072_abnormal_retinal_apoptosis0.94292419
74MP0003632_abnormal_nervous_system0.93818754
75MP0004885_abnormal_endolymph0.93589801
76MP0004484_altered_response_of0.93285692
77MP0002876_abnormal_thyroid_physiology0.93166017
78MP0004085_abnormal_heartbeat0.92636005
79MP0003122_maternal_imprinting0.91622273
80MP0005535_abnormal_body_temperature0.90823151
81MP0004233_abnormal_muscle_weight0.90454278
82MP0005645_abnormal_hypothalamus_physiol0.89057836
83MP0000920_abnormal_myelination0.88772597
84MP0001177_atelectasis0.88156503
85MP0002152_abnormal_brain_morphology0.85710259
86MP0008872_abnormal_physiological_respon0.84855254
87MP0004130_abnormal_muscle_cell0.84295457
88MP0010234_abnormal_vibrissa_follicle0.83447209
89MP0005379_endocrine/exocrine_gland_phen0.82372556
90MP0001529_abnormal_vocalization0.82247567
91MP0002069_abnormal_eating/drinking_beha0.82142213
92MP0005248_abnormal_Harderian_gland0.81425159
93MP0004215_abnormal_myocardial_fiber0.80401001
94MP0003137_abnormal_impulse_conducting0.79848213
95MP0001299_abnormal_eye_distance/0.79215521
96MP0002234_abnormal_pharynx_morphology0.77158562
97MP0002090_abnormal_vision0.75764478
98MP0003634_abnormal_glial_cell0.75737019
99MP0002163_abnormal_gland_morphology0.75585642
100MP0004043_abnormal_pH_regulation0.73474078
101MP0004036_abnormal_muscle_relaxation0.73031842
102MP0004147_increased_porphyrin_level0.72210481
103MP0003075_altered_response_to0.72087580
104MP0001485_abnormal_pinna_reflex0.71890742
105MP0000516_abnormal_urinary_system0.70160001
106MP0005367_renal/urinary_system_phenotyp0.70160001
107MP0001963_abnormal_hearing_physiology0.69755788
108MP0001664_abnormal_digestion0.68667480
109MP0005410_abnormal_fertilization0.67362428
110MP0002160_abnormal_reproductive_system0.64585414
111MP0000639_abnormal_adrenal_gland0.63352554
112MP0000747_muscle_weakness0.62351833
113MP0001765_abnormal_ion_homeostasis0.60371453
114MP0000569_abnormal_digit_pigmentation0.59708548
115MP0005171_absent_coat_pigmentation0.58620848
116MP0002752_abnormal_somatic_nervous0.56495200
117MP0005167_abnormal_blood-brain_barrier0.55849833
118MP0000026_abnormal_inner_ear0.55073540
119MP0008961_abnormal_basal_metabolism0.55063355
120MP0004742_abnormal_vestibular_system0.54550298
121MP0005391_vision/eye_phenotype0.54084619
122MP0003045_fibrosis0.53680664
123MP0000631_abnormal_neuroendocrine_gland0.53412716
124MP0003956_abnormal_body_size0.52147070

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.99719846
2Atonic seizures (HP:0010819)5.75932191
3Myokymia (HP:0002411)5.45666676
4Focal seizures (HP:0007359)5.44056557
5Febrile seizures (HP:0002373)5.05386567
6Epileptic encephalopathy (HP:0200134)5.00912212
7Visual hallucinations (HP:0002367)4.79469259
8Absence seizures (HP:0002121)4.45339772
9Progressive cerebellar ataxia (HP:0002073)4.15452273
10Dialeptic seizures (HP:0011146)3.97578859
11Generalized tonic-clonic seizures (HP:0002069)3.84807144
12Gaze-evoked nystagmus (HP:0000640)3.70032714
13Hyperventilation (HP:0002883)3.66427278
14Action tremor (HP:0002345)3.56152139
15Degeneration of the lateral corticospinal tracts (HP:0002314)3.47552159
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.47552159
17Dysdiadochokinesis (HP:0002075)3.18990071
18Truncal ataxia (HP:0002078)3.17635372
19J-shaped sella turcica (HP:0002680)3.05812245
20Impaired vibration sensation in the lower limbs (HP:0002166)3.04093026
21Depression (HP:0000716)2.99678155
22Broad-based gait (HP:0002136)2.98328522
23Scanning speech (HP:0002168)2.94956642
24Progressive inability to walk (HP:0002505)2.93126935
25Ankle clonus (HP:0011448)2.92373673
26Supranuclear gaze palsy (HP:0000605)2.91241648
27Dysmetria (HP:0001310)2.90891057
28Papilledema (HP:0001085)2.90021638
29Pheochromocytoma (HP:0002666)2.89549847
30Dysmetric saccades (HP:0000641)2.88665140
31Gait imbalance (HP:0002141)2.83725403
32Poor eye contact (HP:0000817)2.78343086
33Urinary bladder sphincter dysfunction (HP:0002839)2.78068064
34Anxiety (HP:0000739)2.74785411
35Postural instability (HP:0002172)2.73675719
36Impaired smooth pursuit (HP:0007772)2.70964967
37Impaired social interactions (HP:0000735)2.67412723
38Abnormal social behavior (HP:0012433)2.67412723
39Papillary thyroid carcinoma (HP:0002895)2.63648273
40Neuroendocrine neoplasm (HP:0100634)2.63172786
41Exercise-induced muscle cramps (HP:0003710)2.62146581
42Limb dystonia (HP:0002451)2.60976405
43Amblyopia (HP:0000646)2.59575840
44Status epilepticus (HP:0002133)2.51631992
45Cerebral inclusion bodies (HP:0100314)2.51080082
46Medial flaring of the eyebrow (HP:0010747)2.50743557
47Bradykinesia (HP:0002067)2.45861566
48Abnormal eating behavior (HP:0100738)2.45176202
49Neurofibrillary tangles (HP:0002185)2.45058634
50Abnormality of the lower motor neuron (HP:0002366)2.44703254
51Epileptiform EEG discharges (HP:0011182)2.43676145
52Congenital primary aphakia (HP:0007707)2.41690191
53Urinary urgency (HP:0000012)2.37745077
54Amyotrophic lateral sclerosis (HP:0007354)2.36733646
55Abnormality of ocular smooth pursuit (HP:0000617)2.36345015
56Termporal pattern (HP:0011008)2.34514681
57Insidious onset (HP:0003587)2.34514681
58Spastic gait (HP:0002064)2.32397171
59Intention tremor (HP:0002080)2.31753743
60Hemiplegia (HP:0002301)2.30825719
61Morphological abnormality of the pyramidal tract (HP:0002062)2.29623231
62EEG with generalized epileptiform discharges (HP:0011198)2.29564003
63Excessive salivation (HP:0003781)2.27399661
64Drooling (HP:0002307)2.27399661
65Resting tremor (HP:0002322)2.25341509
66Impaired vibratory sensation (HP:0002495)2.23742885
67Genetic anticipation (HP:0003743)2.22978219
68Abnormality of binocular vision (HP:0011514)2.21230687
69Diplopia (HP:0000651)2.21230687
70Agitation (HP:0000713)2.18305559
71Nephrogenic diabetes insipidus (HP:0009806)2.17152118
72Blue irides (HP:0000635)2.14463401
73Dyskinesia (HP:0100660)2.13708136
74Volvulus (HP:0002580)2.12841364
75Delusions (HP:0000746)2.12604530
76Hypsarrhythmia (HP:0002521)2.09422210
77Gait ataxia (HP:0002066)2.09077874
78Inability to walk (HP:0002540)2.08379707
79Genital tract atresia (HP:0001827)2.08185188
80Tubulointerstitial nephritis (HP:0001970)2.07683529
81Torticollis (HP:0000473)2.06637731
82Lower limb muscle weakness (HP:0007340)2.06457991
83Focal dystonia (HP:0004373)2.02352654
84Absent speech (HP:0001344)2.01602923
85Vertebral arch anomaly (HP:0008438)1.99275089
86Abnormality of saccadic eye movements (HP:0000570)1.98998630
87Menstrual irregularities (HP:0000858)1.96015777
88Polyphagia (HP:0002591)1.94970165
89True hermaphroditism (HP:0010459)1.94393021
90Hemiparesis (HP:0001269)1.93349772
91Psychosis (HP:0000709)1.92656058
92Vaginal atresia (HP:0000148)1.92467713
93Generalized myoclonic seizures (HP:0002123)1.92391278
94Stereotypic behavior (HP:0000733)1.91662609
95Mutism (HP:0002300)1.88880043
96Microglossia (HP:0000171)1.88856189
97Abnormality of liposaccharide metabolism (HP:0010968)1.87848810
98Abnormality of glycosphingolipid metabolism (HP:0004343)1.87848810
99Abnormality of glycolipid metabolism (HP:0010969)1.87848810
100Akinesia (HP:0002304)1.87829367
101Abnormality of the corticospinal tract (HP:0002492)1.87343840
102Bundle branch block (HP:0011710)1.86349721
103Rigidity (HP:0002063)1.86255278
104Specific learning disability (HP:0001328)1.85544869
105Fetal akinesia sequence (HP:0001989)1.83205178
106Astrocytoma (HP:0009592)1.82616510
107Abnormality of the astrocytes (HP:0100707)1.82616510
108Neoplasm of the peripheral nervous system (HP:0100007)1.82583667
109Neuronal loss in central nervous system (HP:0002529)1.82499567
110Aplasia/Hypoplasia of the tibia (HP:0005772)1.82446475
111Protruding tongue (HP:0010808)1.81242706
112Craniofacial dystonia (HP:0012179)1.80814811
113Limb ataxia (HP:0002070)1.80190842
114Aplasia/Hypoplasia of the tongue (HP:0010295)1.78825605
115Short tibia (HP:0005736)1.78306490
116Postural tremor (HP:0002174)1.78001764
117Abnormal gallbladder physiology (HP:0012438)1.77841698
118Cholecystitis (HP:0001082)1.77841698
119Thyroid carcinoma (HP:0002890)1.76357518
120Retinal dysplasia (HP:0007973)1.74351217
121Palpebral edema (HP:0100540)1.73532206
122Rapidly progressive (HP:0003678)1.72083375
123Ventricular fibrillation (HP:0001663)1.71940964
124Glioma (HP:0009733)1.71885107
125Pancreatic fibrosis (HP:0100732)1.71638063
126Clonus (HP:0002169)1.71333236
127Incomplete penetrance (HP:0003829)1.71135347
128Type II lissencephaly (HP:0007260)1.70451318
129Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68664339
130Generalized hypopigmentation of hair (HP:0011358)1.68452341
131Poor coordination (HP:0002370)1.68418302
132Impaired pain sensation (HP:0007328)1.67258074
133Central scotoma (HP:0000603)1.65094754
134CNS hypomyelination (HP:0003429)1.63063703
135Metaphyseal dysplasia (HP:0100255)1.62026325
136Transitional cell carcinoma of the bladder (HP:0006740)1.61950354
137Pancreatic cysts (HP:0001737)1.59364117
138Nephronophthisis (HP:0000090)1.58800855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.23509501
2MAP3K93.37992851
3MAP3K43.29836445
4MAP3K123.19351371
5EPHA43.08779814
6MAP2K73.01652907
7ERBB32.77665033
8DAPK22.65013570
9CASK2.52359317
10CDK192.46832527
11MAP2K42.38808928
12MINK12.38735381
13NTRK12.21376461
14DAPK12.01885295
15BCR2.01354527
16PAK61.98154205
17PRKD31.84759836
18TRIM281.78844112
19KSR21.72239394
20RIPK41.71774361
21CAMKK11.65164218
22CAMKK21.63754937
23PLK21.61308972
24GRK51.61158264
25ARAF1.48097709
26OXSR11.46817944
27TNIK1.42935954
28STK38L1.40707585
29STK381.40452162
30CDK51.38144120
31PNCK1.33481421
32PDK31.30661454
33PDK41.30661454
34NTRK21.25896463
35MAP4K21.25109362
36MARK11.24271486
37MAP3K21.24099383
38PRKCG1.16907899
39PTK2B1.15613851
40MAP3K131.13891288
41PINK11.10104735
42MUSK1.08866999
43FES1.08776082
44BMPR1B1.05119131
45RET1.05092634
46CAMK2A1.04327177
47SGK2231.00770024
48SGK4941.00770024
49KSR10.99318736
50PRPF4B0.98713670
51CAMK2D0.98688842
52CSNK1A1L0.98446298
53TNK20.97739693
54CAMK10.94791657
55WNK30.93246528
56PRKCH0.91838714
57OBSCN0.91230408
58AKT30.90816302
59CAMK2B0.90063233
60PDK10.88013427
61MAPK130.86853230
62SGK20.85014122
63UHMK10.84692973
64CSNK1G30.82674865
65PAK30.82192283
66CCNB10.81283874
67PKN10.79710859
68FER0.77089029
69LATS20.76819995
70CSNK1G10.74656537
71PDPK10.73874848
72CDK140.70235086
73MAPKAPK50.70025801
74CDK180.69942196
75STK110.68940253
76PRKCE0.68501432
77CDK150.68108047
78SGK30.66609867
79CAMK2G0.65588992
80MAP3K10.64810503
81WNK10.63721216
82BRSK20.61266395
83STK390.61164195
84BMPR20.61038468
85RAF10.60748861
86PDK20.59520646
87CAMK40.58143117
88MKNK20.57413722
89PHKG10.57240980
90PHKG20.57240980
91SGK10.56709128
92CDK11A0.56436605
93TYRO30.55461374
94SIK20.54987277
95LMTK20.54412159
96FGFR20.52349096
97EIF2AK30.52129276
98CSNK1G20.51436155
99DAPK30.51319472
100CAMK1G0.51198160
101WEE10.50222580
102FRK0.49889217
103CDK30.48911025
104MAP2K10.48798032
105SCYL20.48726259
106MAP3K70.48032438
107RPS6KA40.47899211
108DYRK1A0.45906201
109ROCK20.45551152
110ERBB20.45063169
111RPS6KB10.44665719
112BRSK10.44320408
113GRK70.43120158
114RPS6KA30.42547483
115PLK30.42080492
116CSNK1D0.41747473
117INSRR0.40304699
118MOS0.40157760
119NEK60.39940847
120ERBB40.39690560
121ROCK10.38381093
122FYN0.37438549
123MKNK10.36309932
124TAOK10.35039347
125ACVR1B0.34531285
126MAPK100.33814966
127PRKCB0.31193749
128FGR0.30960787

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.63508043
2Synaptic vesicle cycle_Homo sapiens_hsa047213.51454009
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65968437
4GABAergic synapse_Homo sapiens_hsa047272.59745657
5Long-term potentiation_Homo sapiens_hsa047202.55316136
6Circadian entrainment_Homo sapiens_hsa047132.50503180
7Olfactory transduction_Homo sapiens_hsa047402.45462183
8Glutamatergic synapse_Homo sapiens_hsa047242.33497706
9Morphine addiction_Homo sapiens_hsa050322.32628569
10Amphetamine addiction_Homo sapiens_hsa050312.26494647
11Salivary secretion_Homo sapiens_hsa049702.08408489
12Collecting duct acid secretion_Homo sapiens_hsa049662.06750230
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98996334
14Taste transduction_Homo sapiens_hsa047421.96839763
15Insulin secretion_Homo sapiens_hsa049111.95853158
16Dopaminergic synapse_Homo sapiens_hsa047281.94042908
17Gastric acid secretion_Homo sapiens_hsa049711.76431011
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72176411
19Long-term depression_Homo sapiens_hsa047301.63587244
20Renin secretion_Homo sapiens_hsa049241.61965221
21Cholinergic synapse_Homo sapiens_hsa047251.58972437
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55366948
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53101407
24Nitrogen metabolism_Homo sapiens_hsa009101.52016529
25Oxytocin signaling pathway_Homo sapiens_hsa049211.51132724
26Serotonergic synapse_Homo sapiens_hsa047261.50218617
27Calcium signaling pathway_Homo sapiens_hsa040201.49628318
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48606329
29Vitamin B6 metabolism_Homo sapiens_hsa007501.46890568
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46478698
31Propanoate metabolism_Homo sapiens_hsa006401.43294377
32Vibrio cholerae infection_Homo sapiens_hsa051101.36711199
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24853151
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23633256
35GnRH signaling pathway_Homo sapiens_hsa049121.22034790
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21876145
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17144443
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16341242
39cAMP signaling pathway_Homo sapiens_hsa040241.15299851
40Cocaine addiction_Homo sapiens_hsa050301.14318813
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13051806
42Gap junction_Homo sapiens_hsa045401.06134999
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02685078
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01480758
45Estrogen signaling pathway_Homo sapiens_hsa049150.99593364
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98493700
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97065913
48Type II diabetes mellitus_Homo sapiens_hsa049300.95343963
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94708101
50Cardiac muscle contraction_Homo sapiens_hsa042600.94134804
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89697696
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88240252
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.88110759
54Glioma_Homo sapiens_hsa052140.87795773
55beta-Alanine metabolism_Homo sapiens_hsa004100.86579260
56Pancreatic secretion_Homo sapiens_hsa049720.86269688
57Thyroid hormone synthesis_Homo sapiens_hsa049180.85161424
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84622489
59Fatty acid biosynthesis_Homo sapiens_hsa000610.82122597
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79036167
61Melanogenesis_Homo sapiens_hsa049160.78978473
62ErbB signaling pathway_Homo sapiens_hsa040120.78485724
63Glucagon signaling pathway_Homo sapiens_hsa049220.78232041
64Protein export_Homo sapiens_hsa030600.76693733
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76540486
66Regulation of autophagy_Homo sapiens_hsa041400.75540708
67Dilated cardiomyopathy_Homo sapiens_hsa054140.71112297
68Dorso-ventral axis formation_Homo sapiens_hsa043200.69019508
69Bile secretion_Homo sapiens_hsa049760.68849690
70Axon guidance_Homo sapiens_hsa043600.65418898
71Arginine biosynthesis_Homo sapiens_hsa002200.62058377
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.60583818
73Oocyte meiosis_Homo sapiens_hsa041140.60577638
74Inositol phosphate metabolism_Homo sapiens_hsa005620.60148367
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.59506108
76Phototransduction_Homo sapiens_hsa047440.56539289
77Alzheimers disease_Homo sapiens_hsa050100.56199431
78Fatty acid elongation_Homo sapiens_hsa000620.56121336
79Oxidative phosphorylation_Homo sapiens_hsa001900.53974115
80Fatty acid metabolism_Homo sapiens_hsa012120.53907360
81Butanoate metabolism_Homo sapiens_hsa006500.52713691
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52443111
83Steroid biosynthesis_Homo sapiens_hsa001000.51140194
84Wnt signaling pathway_Homo sapiens_hsa043100.51110658
85Pyruvate metabolism_Homo sapiens_hsa006200.50346319
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49096671
87MAPK signaling pathway_Homo sapiens_hsa040100.48994761
88Histidine metabolism_Homo sapiens_hsa003400.47832009
89AMPK signaling pathway_Homo sapiens_hsa041520.47739068
90Ovarian steroidogenesis_Homo sapiens_hsa049130.46113588
91Endometrial cancer_Homo sapiens_hsa052130.46052465
92Hippo signaling pathway_Homo sapiens_hsa043900.45098879
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44671151
94Rap1 signaling pathway_Homo sapiens_hsa040150.43326460
95Choline metabolism in cancer_Homo sapiens_hsa052310.43000845
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42449950
97Ras signaling pathway_Homo sapiens_hsa040140.42339359
98Circadian rhythm_Homo sapiens_hsa047100.42227571
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41862335
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.39943192
101Endocytosis_Homo sapiens_hsa041440.38320261
102Insulin signaling pathway_Homo sapiens_hsa049100.37936221
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36375589
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35977453
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35421250
106Rheumatoid arthritis_Homo sapiens_hsa053230.35314283
107ABC transporters_Homo sapiens_hsa020100.35250531
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35131478
109Arginine and proline metabolism_Homo sapiens_hsa003300.34615331
110Prion diseases_Homo sapiens_hsa050200.33474914
111Fatty acid degradation_Homo sapiens_hsa000710.33392809
112Type I diabetes mellitus_Homo sapiens_hsa049400.32814010
113Tight junction_Homo sapiens_hsa045300.32798817
114Colorectal cancer_Homo sapiens_hsa052100.32406427
115Phagosome_Homo sapiens_hsa041450.32214520
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31915047
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31839911
118VEGF signaling pathway_Homo sapiens_hsa043700.31672979
119mTOR signaling pathway_Homo sapiens_hsa041500.30928227
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.30691437
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29303621
122Alcoholism_Homo sapiens_hsa050340.28523544
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27428755
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26250420
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24382376
126Platelet activation_Homo sapiens_hsa046110.23302636

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