OXSR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.03476479
2daunorubicin metabolic process (GO:0044597)5.98073371
3polyketide metabolic process (GO:0030638)5.98073371
4doxorubicin metabolic process (GO:0044598)5.98073371
5nuclear pore complex assembly (GO:0051292)5.81901775
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.66555684
7heterochromatin organization (GO:0070828)5.48252112
8pre-miRNA processing (GO:0031054)5.40847246
9nuclear pore organization (GO:0006999)5.34678988
10regulation of telomere maintenance via telomerase (GO:0032210)5.26260304
11negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.98279142
12negative regulation of cell cycle G2/M phase transition (GO:1902750)4.97466001
13histone H4-K8 acetylation (GO:0043982)4.76626631
14histone H4-K5 acetylation (GO:0043981)4.76626631
15histone H4-K12 acetylation (GO:0043983)4.67081304
16chromatin assembly (GO:0031497)4.66587552
17negative regulation of telomerase activity (GO:0051974)4.64334966
18mitotic sister chromatid segregation (GO:0000070)4.62678138
19regulation of gene silencing by RNA (GO:0060966)4.54381103
20regulation of posttranscriptional gene silencing (GO:0060147)4.54381103
21regulation of gene silencing by miRNA (GO:0060964)4.54381103
22maintenance of protein location in nucleus (GO:0051457)4.46956616
23NLS-bearing protein import into nucleus (GO:0006607)4.45463608
24protein localization to chromosome, centromeric region (GO:0071459)4.41661932
25regulation of mammary gland epithelial cell proliferation (GO:0033599)4.36184379
26sister chromatid segregation (GO:0000819)4.35408211
27regulation of RNA export from nucleus (GO:0046831)4.25605338
28regulation of nuclear cell cycle DNA replication (GO:0033262)4.24517717
29DNA replication-dependent nucleosome assembly (GO:0006335)4.18014392
30DNA replication-dependent nucleosome organization (GO:0034723)4.18014392
31negative regulation of epidermis development (GO:0045683)4.13368383
32pore complex assembly (GO:0046931)4.12053348
33muscle organ morphogenesis (GO:0048644)4.09752786
34notochord development (GO:0030903)4.09714976
35hemidesmosome assembly (GO:0031581)4.05381160
36somite rostral/caudal axis specification (GO:0032525)4.01794868
37RNA stabilization (GO:0043489)4.00735904
38mRNA stabilization (GO:0048255)4.00735904
39protein localization to endosome (GO:0036010)3.99343692
40regulation of hippo signaling (GO:0035330)3.95289851
41regulation of response to osmotic stress (GO:0047484)3.92061298
42trophectodermal cell differentiation (GO:0001829)3.91509003
43histone H4-K16 acetylation (GO:0043984)3.91249922
44positive regulation of histone deacetylation (GO:0031065)3.89417484
45skin morphogenesis (GO:0043589)3.80725578
46aminoglycoside antibiotic metabolic process (GO:0030647)3.76088522
47DNA duplex unwinding (GO:0032508)3.73193521
48mitotic chromosome condensation (GO:0007076)3.72717908
49regulation of nucleobase-containing compound transport (GO:0032239)3.71790951
50DNA geometric change (GO:0032392)3.70154063
51intestinal epithelial cell development (GO:0060576)3.68884531
52hormone catabolic process (GO:0042447)3.63456667
53regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.56263273
54Golgi transport vesicle coating (GO:0048200)3.50394870
55COPI coating of Golgi vesicle (GO:0048205)3.50394870
56positive regulation of protein deacetylation (GO:0090312)3.48978299
57regulation of MHC class I biosynthetic process (GO:0045343)3.47059817
58cell-substrate junction assembly (GO:0007044)3.45334012
59maternal placenta development (GO:0001893)3.43290136
60cell adhesion mediated by integrin (GO:0033627)3.41849756
61DNA unwinding involved in DNA replication (GO:0006268)3.41092873
62rRNA transcription (GO:0009303)3.40667832
63cytidine metabolic process (GO:0046087)3.40274302
64cytidine catabolic process (GO:0006216)3.40274302
65cytidine deamination (GO:0009972)3.40274302
66branching involved in mammary gland duct morphogenesis (GO:0060444)3.35405913
67intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.30935461
68positive regulation of DNA-dependent DNA replication (GO:2000105)3.29453776
69negative regulation of DNA repair (GO:0045738)3.25200820
70regulation of NFAT protein import into nucleus (GO:0051532)3.21250646
71protein localization to microtubule (GO:0035372)3.20611891
72mammary gland epithelial cell proliferation (GO:0033598)3.19597704
73anterior/posterior axis specification, embryo (GO:0008595)3.18698963
74determination of adult lifespan (GO:0008340)3.17704428
75regulation of translation in response to stress (GO:0043555)3.16203778
76primitive streak formation (GO:0090009)3.13930996
77regulation of early endosome to late endosome transport (GO:2000641)3.13889753
78mitotic nuclear envelope disassembly (GO:0007077)3.13882071
79negative regulation of cell size (GO:0045792)3.13218947
80mitotic sister chromatid cohesion (GO:0007064)3.11386123
81regulation of translational termination (GO:0006449)3.05659369
82nuclear envelope disassembly (GO:0051081)3.04276923
83membrane disassembly (GO:0030397)3.04276923
84positive regulation of SMAD protein import into nucleus (GO:0060391)3.02669335
85cell-substrate adherens junction assembly (GO:0007045)3.02025046
86focal adhesion assembly (GO:0048041)3.02025046
87regulation of histone H3-K27 methylation (GO:0061085)3.01225901
88embryonic process involved in female pregnancy (GO:0060136)2.99314418
89protein export from nucleus (GO:0006611)2.99227226
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98781966
91DNA replication checkpoint (GO:0000076)2.98133671
92negative regulation of histone methylation (GO:0031061)2.95600656
93embryonic placenta development (GO:0001892)2.95401953
94intracellular estrogen receptor signaling pathway (GO:0030520)2.95259948
95cell fate commitment involved in formation of primary germ layer (GO:0060795)2.94795225
96cellular protein complex localization (GO:0034629)2.93787196
97intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.90173113
98spindle assembly (GO:0051225)2.89115226
99regulation of telomere maintenance (GO:0032204)2.87929916
100regulation of translational fidelity (GO:0006450)2.87617573
101folic acid-containing compound biosynthetic process (GO:0009396)2.84402511
102positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.83851173
103COPII vesicle coating (GO:0048208)2.83031520
104adherens junction assembly (GO:0034333)2.82106385
105regulation of gene silencing (GO:0060968)2.80924345
106negative regulation of gene silencing (GO:0060969)2.80617670
107cellular senescence (GO:0090398)2.77352273
108positive regulation of protein export from nucleus (GO:0046827)2.76531909
109negative regulation of epidermal cell differentiation (GO:0045605)2.73700109
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72832596
111negative regulation of DNA biosynthetic process (GO:2000279)2.72595744
112negative regulation of anoikis (GO:2000811)2.72336829
113establishment of endothelial barrier (GO:0061028)2.71585227
114polarized epithelial cell differentiation (GO:0030859)2.71423218
115cellular modified amino acid catabolic process (GO:0042219)2.69874924
116formation of translation preinitiation complex (GO:0001731)2.68829620
117interferon-gamma production (GO:0032609)2.68213044
118DNA conformation change (GO:0071103)2.68090325
119epoxygenase P450 pathway (GO:0019373)2.67450879
120protein localization to chromosome (GO:0034502)2.63591603
121pinocytosis (GO:0006907)2.62614982
122paraxial mesoderm development (GO:0048339)2.62450175
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.62157985
124regulation of mRNA stability (GO:0043488)2.61883288
125retinoic acid receptor signaling pathway (GO:0048384)2.61798818
126regulation of glucose import in response to insulin stimulus (GO:2001273)2.60494724
127regulation of vitamin D biosynthetic process (GO:0060556)2.58894734
128desmosome organization (GO:0002934)2.58257758
129regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.58126860
130positive regulation of protein import into nucleus, translocation (GO:0033160)2.57541708
1313-UTR-mediated mRNA stabilization (GO:0070935)2.57326077
132epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55833276
133negative regulation of erythrocyte differentiation (GO:0045647)2.54368540
134regulation of G0 to G1 transition (GO:0070316)2.54274548
135cell migration involved in gastrulation (GO:0042074)2.54216788
136vesicle coating (GO:0006901)2.49186870
137stress fiber assembly (GO:0043149)2.47383443
138DNA topological change (GO:0006265)2.46306753
139positive regulation of blood vessel endothelial cell migration (GO:0043536)2.45060891
140regulation of transforming growth factor beta2 production (GO:0032909)2.44706047
141endodermal cell differentiation (GO:0035987)2.42908023
142epithelial cell-cell adhesion (GO:0090136)2.42754795
143cortical actin cytoskeleton organization (GO:0030866)2.41645587
144regulation of mitotic spindle organization (GO:0060236)2.39806036
145mesodermal cell differentiation (GO:0048333)2.35854818
146ER-nucleus signaling pathway (GO:0006984)2.33486625
147regulation of sister chromatid cohesion (GO:0007063)2.32785258
148hippo signaling (GO:0035329)2.32586309
149endoplasmic reticulum unfolded protein response (GO:0030968)2.31455761
150chromosome condensation (GO:0030261)2.30969100
151negative regulation of fibroblast apoptotic process (GO:2000270)2.30922612
152mitotic metaphase plate congression (GO:0007080)2.30324183
153histone H3-K9 demethylation (GO:0033169)2.29472560
154dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.28849906
155regulation of protein export from nucleus (GO:0046825)2.28768716
156protein complex localization (GO:0031503)2.28683056
157nuclear envelope organization (GO:0006998)2.28302594
158regulation of anoikis (GO:2000209)2.27754103
159response to laminar fluid shear stress (GO:0034616)2.26736672
160glucocorticoid receptor signaling pathway (GO:0042921)2.26527250
161histone H3-K36 demethylation (GO:0070544)2.25467367
162positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.24170334
163iron ion import (GO:0097286)2.23886746
164activation of Rac GTPase activity (GO:0032863)2.23478228
165regulation of histone H3-K9 methylation (GO:0051570)2.22172411
166positive regulation of nuclease activity (GO:0032075)2.21476071
167regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.21454946
168activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.21450088
169response to epidermal growth factor (GO:0070849)2.20525864
170membrane raft organization (GO:0031579)2.19865303
171cytoskeletal anchoring at plasma membrane (GO:0007016)2.18880603
172positive regulation of keratinocyte differentiation (GO:0045618)2.18766082
173trophoblast giant cell differentiation (GO:0060707)2.18517627
174response to peptidoglycan (GO:0032494)2.16613976
175positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.15339128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.88361332
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.01418204
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.01418204
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.01418204
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.66559056
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.59071855
7POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.01118733
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.00083342
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.79980805
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.79248372
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.63639717
12SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.55349717
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52859525
14CLOCK_20551151_ChIP-Seq_293T_Human2.49621433
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.40197122
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.39592800
17TCF3_18692474_ChIP-Seq_MESCs_Mouse2.33235606
18ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.30596723
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27596396
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.26594129
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.23858797
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.22691952
23MYC_22102868_ChIP-Seq_BL_Human2.17515005
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11084592
25STAT3_1855785_ChIP-Seq_MESCs_Mouse2.10428792
26SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.09914923
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08244720
28ZNF263_19887448_ChIP-Seq_K562_Human2.05336038
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03828647
30NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.01834865
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.98353116
32NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83830228
33* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82790616
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81583707
35* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79286906
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.77689635
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.77689635
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77405993
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77334701
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73773965
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.69332885
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68895195
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67434399
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66898267
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63908125
46POU5F1_16518401_ChIP-PET_MESCs_Mouse1.61338999
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61079336
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58869275
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56955627
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.56146324
51NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.56092073
52TCF7_22412390_ChIP-Seq_EML_Mouse1.53596872
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52979547
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51508531
55GATA1_22025678_ChIP-Seq_K562_Human1.50534692
56TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.48349166
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48042105
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43083625
59UBF1/2_26484160_Chip-Seq_HMECs_Human1.41489753
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41054300
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40864824
62NANOG_18692474_ChIP-Seq_MESCs_Mouse1.40748390
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40251747
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38238242
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35528551
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.34971615
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34901341
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.34867792
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34402928
70NANOG_18692474_ChIP-Seq_MEFs_Mouse1.33858674
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33674209
72PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.33636393
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33393404
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32654121
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30583604
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28319039
77TFEB_21752829_ChIP-Seq_HELA_Human1.28122918
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27889065
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27660726
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26739738
81SOX2_18692474_ChIP-Seq_MESCs_Mouse1.26059750
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25883138
83OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25702860
84* VDR_21846776_ChIP-Seq_THP-1_Human1.22975794
85* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21954875
86POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.21797471
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21492423
88* NCOR1_26117541_ChIP-Seq_K562_Human1.21376672
89MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21076552
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20940811
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20799166
92KDM2B_26808549_Chip-Seq_DND41_Human1.20742766
93NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20257945
94* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20049871
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.18963406
96* ELK3_25401928_ChIP-Seq_HUVEC_Human1.18636307
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17448373
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17255369
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17118654
100NANOG_16518401_ChIP-PET_MESCs_Mouse1.16870619
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16703566
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16070259
103CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15842375
104AR_21909140_ChIP-Seq_LNCAP_Human1.15680805
105SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13758929
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13389796
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13287467
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11629888
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10685362
110RACK7_27058665_Chip-Seq_MCF-7_Human1.10130249
111SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09386815
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09342669
113ATF3_27146783_Chip-Seq_COLON_Human1.09329215
114BRD4_25478319_ChIP-Seq_HGPS_Human1.08664805
115SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08549066
116TP53_22127205_ChIP-Seq_IMR90_Human1.07165770
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07018504
118POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05735488
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04963951
120MAF_26560356_Chip-Seq_TH1_Human1.04485107
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04209504
122TP63_17297297_ChIP-ChIP_HaCaT_Human1.03003101
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02776460
124CDX2_20551321_ChIP-Seq_CACO-2_Human1.00652983
125MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00052677
126KDM2B_26808549_Chip-Seq_K562_Human0.99432992
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98612902
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97334122
129* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97012008
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95557112
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95478837
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94799366
133KDM2B_26808549_Chip-Seq_JURKAT_Human0.94302162
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93906831
135GATA6_25053715_ChIP-Seq_YYC3_Human0.92670529
136TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92494061
137TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91855208
138TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90464403
139FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89335542
140PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88511792
141E2F1_21310950_ChIP-Seq_MCF-7_Human0.87602809
142KDM5A_27292631_Chip-Seq_BREAST_Human0.86626966
143SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86603076
144CHD1_26751641_Chip-Seq_LNCaP_Human0.85392294
145NANOG_16153702_ChIP-ChIP_HESCs_Human0.85294542
146DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84014670
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83313863
148TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82553590
149TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82280775
150CREB1_26743006_Chip-Seq_LNCaP_Human0.80846039
151CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80766032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.34278511
2MP0004264_abnormal_extraembryonic_tissu3.79812529
3MP0010352_gastrointestinal_tract_polyps3.68530427
4MP0002254_reproductive_system_inflammat3.25526568
5MP0008438_abnormal_cutaneous_collagen3.22309862
6MP0003890_abnormal_embryonic-extraembry3.12535725
7MP0004957_abnormal_blastocyst_morpholog2.66827303
8MP0004858_abnormal_nervous_system2.57647217
9MP0005451_abnormal_body_composition2.41095182
10MP0003950_abnormal_plasma_membrane2.35680859
11MP0008057_abnormal_DNA_replication2.31693174
12MP0001672_abnormal_embryogenesis/_devel2.22320368
13MP0005380_embryogenesis_phenotype2.22320368
14MP0002088_abnormal_embryonic_growth/wei2.17112755
15MP0003984_embryonic_growth_retardation2.16608625
16MP0003941_abnormal_skin_development2.13187692
17MP0002332_abnormal_exercise_endurance2.06647422
18MP0003011_delayed_dark_adaptation2.04543486
19MP0003123_paternal_imprinting2.02078639
20MP0005257_abnormal_intraocular_pressure1.97314925
21MP0004233_abnormal_muscle_weight1.96396686
22MP0010234_abnormal_vibrissa_follicle1.95374529
23MP0005076_abnormal_cell_differentiation1.92699404
24MP0003121_genomic_imprinting1.92318455
25MP0005275_abnormal_skin_tensile1.92269907
26MP0003300_gastrointestinal_ulcer1.91160300
27MP0002086_abnormal_extraembryonic_tissu1.89059263
28MP0000350_abnormal_cell_proliferation1.87243228
29MP0008961_abnormal_basal_metabolism1.85410362
30MP0005499_abnormal_olfactory_system1.84521133
31MP0005394_taste/olfaction_phenotype1.84521133
32MP0003122_maternal_imprinting1.80669080
33MP0001730_embryonic_growth_arrest1.75736587
34MP0003111_abnormal_nucleus_morphology1.75372999
35MP0004197_abnormal_fetal_growth/weight/1.72314634
36MP0001849_ear_inflammation1.70350097
37MP0002084_abnormal_developmental_patter1.69006618
38MP0003077_abnormal_cell_cycle1.68125200
39MP0006292_abnormal_olfactory_placode1.66483233
40MP0003566_abnormal_cell_adhesion1.63068183
41MP0002060_abnormal_skin_morphology1.60427184
42MP0002085_abnormal_embryonic_tissue1.59851471
43MP0008260_abnormal_autophagy1.59636356
44MP0006035_abnormal_mitochondrial_morpho1.56234051
45MP0004185_abnormal_adipocyte_glucose1.50225957
46MP0002877_abnormal_melanocyte_morpholog1.46027408
47MP0002269_muscular_atrophy1.43347547
48MP0001293_anophthalmia1.43340113
49MP0003656_abnormal_erythrocyte_physiolo1.42078112
50MP0004808_abnormal_hematopoietic_stem1.41870212
51MP0001697_abnormal_embryo_size1.41547172
52MP0003119_abnormal_digestive_system1.39603921
53MP0010030_abnormal_orbit_morphology1.38758370
54MP0002653_abnormal_ependyma_morphology1.36894230
55MP0001915_intracranial_hemorrhage1.35657984
56MP0010094_abnormal_chromosome_stability1.35561317
57MP0002127_abnormal_cardiovascular_syste1.35323554
58MP0003283_abnormal_digestive_organ1.32781656
59MP0000579_abnormal_nail_morphology1.31166818
60MP0001216_abnormal_epidermal_layer1.30446158
61MP0000750_abnormal_muscle_regeneration1.30072848
62MP0005623_abnormal_meninges_morphology1.29126014
63MP0005409_darkened_coat_color1.27329564
64MP0000428_abnormal_craniofacial_morphol1.27106795
65MP0004947_skin_inflammation1.26872816
66MP0005501_abnormal_skin_physiology1.26644113
67* MP0002080_prenatal_lethality1.24919696
68MP0004084_abnormal_cardiac_muscle1.24721540
69MP0003191_abnormal_cellular_cholesterol1.24257521
70MP0002925_abnormal_cardiovascular_devel1.23583425
71MP0002396_abnormal_hematopoietic_system1.22432421
72MP0008770_decreased_survivor_rate1.21352315
73MP0004087_abnormal_muscle_fiber1.21154952
74MP0009703_decreased_birth_body1.20936780
75MP0002092_abnormal_eye_morphology1.20106476
76MP0010630_abnormal_cardiac_muscle1.19133288
77MP0000858_altered_metastatic_potential1.18606459
78MP0002009_preneoplasia1.18066511
79MP0005023_abnormal_wound_healing1.16125466
80MP0001958_emphysema1.15616596
81MP0000733_abnormal_muscle_development1.14076494
82MP0005266_abnormal_metabolism1.12572282
83MP0005621_abnormal_cell_physiology1.12051727
84MP0010307_abnormal_tumor_latency1.10575704
85MP0005248_abnormal_Harderian_gland1.09255059
86MP0003935_abnormal_craniofacial_develop1.05645481
87MP0003693_abnormal_embryo_hatching1.04911861
88MP0000749_muscle_degeneration1.02675585
89MP0002006_tumorigenesis1.02508168
90MP0009697_abnormal_copulation1.01847779
91MP0005666_abnormal_adipose_tissue1.00856668
92MP0005075_abnormal_melanosome_morpholog1.00093870
93MP0003448_altered_tumor_morphology0.98321997
94MP0006054_spinal_hemorrhage0.96298173
95MP0002970_abnormal_white_adipose0.96178368
96MP0002896_abnormal_bone_mineralization0.95730333
97MP0002932_abnormal_joint_morphology0.95158853
98MP0000759_abnormal_skeletal_muscle0.94960388
99MP0000432_abnormal_head_morphology0.94604407
100MP0003303_peritoneal_inflammation0.93577339
101MP0001348_abnormal_lacrimal_gland0.92474700
102MP0000266_abnormal_heart_morphology0.90754969
103MP0000313_abnormal_cell_death0.90599177
104MP0000747_muscle_weakness0.88523963
105MP0002166_altered_tumor_susceptibility0.87128714
106MP0005375_adipose_tissue_phenotype0.85741832
107MP0000678_abnormal_parathyroid_gland0.84944125
108MP0009672_abnormal_birth_weight0.84568706
109MP0000003_abnormal_adipose_tissue0.84341754
110MP0005330_cardiomyopathy0.84181662
111MP0003221_abnormal_cardiomyocyte_apopto0.84156901
112MP0000377_abnormal_hair_follicle0.84109116
113MP0000767_abnormal_smooth_muscle0.84102436
114MP0000762_abnormal_tongue_morphology0.82659532
115MP0000490_abnormal_crypts_of0.81881005
116MP0001243_abnormal_dermal_layer0.81227322
117MP0009931_abnormal_skin_appearance0.79687251
118MP0003091_abnormal_cell_migration0.79286143
119MP0002114_abnormal_axial_skeleton0.79286081
120MP0002233_abnormal_nose_morphology0.77032283
121MP0003137_abnormal_impulse_conducting0.76231807
122MP0003755_abnormal_palate_morphology0.76034311
123MP0002998_abnormal_bone_remodeling0.75687403
124MP0009053_abnormal_anal_canal0.75562930
125MP0003385_abnormal_body_wall0.75490824
126MP0003436_decreased_susceptibility_to0.74977808
127MP0001299_abnormal_eye_distance/0.74848519
128MP0000627_abnormal_mammary_gland0.72669970
129MP0004272_abnormal_basement_membrane0.72316763
130MP0010678_abnormal_skin_adnexa0.72093697
131MP0000358_abnormal_cell_content/0.72026331
132MP0003453_abnormal_keratinocyte_physiol0.71457641
133MP0002697_abnormal_eye_size0.69899677
134MP0005384_cellular_phenotype0.69088640
135MP0005167_abnormal_blood-brain_barrier0.68263634
136MP0003938_abnormal_ear_development0.68106312
137MP0008775_abnormal_heart_ventricle0.67899788
138MP0000537_abnormal_urethra_morphology0.67188906
139MP0003828_pulmonary_edema0.66888462
140MP0004133_heterotaxia0.66646790
141MP0002796_impaired_skin_barrier0.66635164
142MP0008932_abnormal_embryonic_tissue0.65528712
143MP0008007_abnormal_cellular_replicative0.65460333

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.23704140
2Ependymoma (HP:0002888)4.87388823
3Hypochromic microcytic anemia (HP:0004840)4.75209729
4Abnormality of the lower motor neuron (HP:0002366)4.63768378
5Multiple enchondromatosis (HP:0005701)4.41390193
6Hepatoblastoma (HP:0002884)4.28585792
7Abnormality of the astrocytes (HP:0100707)4.02599436
8Astrocytoma (HP:0009592)4.02599436
9Premature rupture of membranes (HP:0001788)3.72303823
10Neoplasm of striated muscle (HP:0009728)3.69624774
11Rib fusion (HP:0000902)3.68747271
12Rhabdomyosarcoma (HP:0002859)3.60921079
13Difficulty running (HP:0009046)3.44236332
14Increased connective tissue (HP:0009025)3.41229017
15Protrusio acetabuli (HP:0003179)3.39379330
16Glioma (HP:0009733)2.96403120
17Ankyloglossia (HP:0010296)2.96161516
18Atrophic scars (HP:0001075)2.92876101
19Arterial tortuosity (HP:0005116)2.90364667
20Short humerus (HP:0005792)2.84222305
21Testicular atrophy (HP:0000029)2.81493672
22Fused cervical vertebrae (HP:0002949)2.77604552
23Abnormality of the salivary glands (HP:0010286)2.77265205
24Abnormality of the calcaneus (HP:0008364)2.75502002
25Exercise-induced muscle cramps (HP:0003710)2.74001040
26Aplasia/hypoplasia of the humerus (HP:0006507)2.68954010
27Resting tremor (HP:0002322)2.67620112
28Deep philtrum (HP:0002002)2.65543672
29Vascular tortuosity (HP:0004948)2.63322378
30Achilles tendon contracture (HP:0001771)2.57050395
31Abnormality of nail color (HP:0100643)2.54028663
32Hand muscle atrophy (HP:0009130)2.53448315
33Hyperinsulinemic hypoglycemia (HP:0000825)2.52788320
34Large earlobe (HP:0009748)2.52307412
35Abnormal cartilage morphology (HP:0002763)2.49451187
36Pseudobulbar signs (HP:0002200)2.49323540
37Angiofibromas (HP:0010615)2.45718342
38Adenoma sebaceum (HP:0009720)2.45718342
39Abnormality of oral frenula (HP:0000190)2.45597386
40Asymmetry of the thorax (HP:0001555)2.41513859
41Amyotrophic lateral sclerosis (HP:0007354)2.41332161
42Hypopigmentation of the fundus (HP:0007894)2.40905153
43Nephroblastoma (Wilms tumor) (HP:0002667)2.39740296
44Distal lower limb amyotrophy (HP:0008944)2.38716930
45Osteolytic defects of the hand bones (HP:0009699)2.36423172
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.36423172
47Upper limb amyotrophy (HP:0009129)2.35627711
48Distal upper limb amyotrophy (HP:0007149)2.35627711
49Abnormality of the Achilles tendon (HP:0005109)2.34664476
50Preauricular skin tag (HP:0000384)2.33333095
51Spinal cord lesions (HP:0100561)2.32353160
52Syringomyelia (HP:0003396)2.32353160
53Trismus (HP:0000211)2.31962783
54Skin tags (HP:0010609)2.30710128
55Fragile skin (HP:0001030)2.30618366
56Renal duplication (HP:0000075)2.26534040
57Vertebral arch anomaly (HP:0008438)2.26253713
58Rectovaginal fistula (HP:0000143)2.26011240
59Rectal fistula (HP:0100590)2.26011240
60Disproportionate tall stature (HP:0001519)2.22614648
61Shawl scrotum (HP:0000049)2.20419654
62Medulloblastoma (HP:0002885)2.20313630
63Embryonal renal neoplasm (HP:0011794)2.19695906
64Ragged-red muscle fibers (HP:0003200)2.19526978
65Neoplasm of the heart (HP:0100544)2.19168494
66Hyperacusis (HP:0010780)2.18866534
67Flat acetabular roof (HP:0003180)2.18269404
68Intestinal fistula (HP:0100819)2.18254605
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17608968
70Neoplasm of the oral cavity (HP:0100649)2.16690865
71Abnormality of chromosome segregation (HP:0002916)2.15469418
72Short nail (HP:0001799)2.15257210
73Thick nail (HP:0001805)2.14759032
74Mitral valve prolapse (HP:0001634)2.13171163
75Missing ribs (HP:0000921)2.13168690
76Dilatation of the ascending aorta (HP:0005111)2.13085582
77Aortic dissection (HP:0002647)2.12781383
78Macroorchidism (HP:0000053)2.09871445
79Abnormality of the musculature of the hand (HP:0001421)2.09708421
80Relative macrocephaly (HP:0004482)2.09371511
81Horizontal nystagmus (HP:0000666)2.08881315
82Spinal rigidity (HP:0003306)2.08577132
83Mildly elevated creatine phosphokinase (HP:0008180)2.08427639
84Wormian bones (HP:0002645)2.08229706
85Abnormality of the distal phalanx of the thumb (HP:0009617)2.08226085
86Selective tooth agenesis (HP:0001592)2.06442979
87EMG: neuropathic changes (HP:0003445)2.04753684
88Upper motor neuron abnormality (HP:0002127)2.04623168
89Chromsome breakage (HP:0040012)2.04393003
90Natal tooth (HP:0000695)2.03383710
91Fibroma (HP:0010614)2.01564407
92Aortic aneurysm (HP:0004942)2.01272227
93Type 1 muscle fiber predominance (HP:0003803)2.01218584
94Abnormality of the pubic bones (HP:0003172)2.00763920
95Malignant neoplasm of the central nervous system (HP:0100836)2.00464666
96Broad face (HP:0000283)1.98780946
97Vaginal fistula (HP:0004320)1.97026526
98Ventricular tachycardia (HP:0004756)1.96739435
99Volvulus (HP:0002580)1.96532459
100Ankle contracture (HP:0006466)1.96089945
101Deep palmar crease (HP:0006191)1.94566659
10211 pairs of ribs (HP:0000878)1.94340298
103Overlapping toe (HP:0001845)1.93944356
104Malignant gastrointestinal tract tumors (HP:0006749)1.93349461
105Gastrointestinal carcinoma (HP:0002672)1.93349461
106Vertebral fusion (HP:0002948)1.92695420
107Hypochromic anemia (HP:0001931)1.92541897
108Calcaneovalgus deformity (HP:0001848)1.92327995
109Fibrous tissue neoplasm (HP:0012316)1.92196069
110Milia (HP:0001056)1.91090654
111Lymphangioma (HP:0100764)1.90014222
112Lower limb amyotrophy (HP:0007210)1.88262700
113Cerebral aneurysm (HP:0004944)1.88125748
114Abnormality of skeletal muscle fiber size (HP:0012084)1.87388396
115Onycholysis (HP:0001806)1.86751873
116Neonatal short-limb short stature (HP:0008921)1.85755551
117Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85198831
118Ulnar bowing (HP:0003031)1.84942451
119Impulsivity (HP:0100710)1.84245999
120Progressive muscle weakness (HP:0003323)1.84220660
121Supernumerary ribs (HP:0005815)1.84196652
122Deviation of the thumb (HP:0009603)1.82619266
123Increased nuchal translucency (HP:0010880)1.82356014
124Vertebral compression fractures (HP:0002953)1.82315852
125Tetraplegia (HP:0002445)1.82189521
126Bladder diverticulum (HP:0000015)1.81738394
127Increased variability in muscle fiber diameter (HP:0003557)1.81322328
128Short 5th finger (HP:0009237)1.81211167
129Long palpebral fissure (HP:0000637)1.80575684
130Advanced eruption of teeth (HP:0006288)1.79525373
131Spondylolisthesis (HP:0003302)1.79149146
132Broad palm (HP:0001169)1.78702817
133Heterotopia (HP:0002282)1.78387582
134Right ventricular cardiomyopathy (HP:0011663)1.77723291
135Leiomyosarcoma (HP:0100243)1.77483877
136Uterine leiomyosarcoma (HP:0002891)1.77483877
137Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76686334
138Joint laxity (HP:0001388)1.76595858
139Fasciculations (HP:0002380)1.76120225
140Prominent nose (HP:0000448)1.75819729
141Periauricular skin pits (HP:0100277)1.75647604
142Preauricular pit (HP:0004467)1.75647604
143Shallow orbits (HP:0000586)1.75463842
144Mitral regurgitation (HP:0001653)1.75424645
145Acute myeloid leukemia (HP:0004808)1.74720435
146Difficulty climbing stairs (HP:0003551)1.74470744
147Abnormal lung lobation (HP:0002101)1.74370029
148Termporal pattern (HP:0011008)1.74279681
149Insidious onset (HP:0003587)1.74279681
150Ridged nail (HP:0001807)1.73737787
151Nervous tissue neoplasm (HP:0030060)1.73701695
152Neuroectodermal neoplasm (HP:0030061)1.73701695
153Neuroepithelial neoplasm (HP:0030063)1.73701695
154Blue sclerae (HP:0000592)1.73656110
155Soft skin (HP:0000977)1.73252054
156Micronodular cirrhosis (HP:0001413)1.72856409
157Nemaline bodies (HP:0003798)1.72648818
158Breech presentation (HP:0001623)1.72539642
159Long eyelashes (HP:0000527)1.71852695
160Genu recurvatum (HP:0002816)1.70738398
161Limited elbow extension (HP:0001377)1.70611638
162Skin pits (HP:0100276)1.69846732
163Generalized hypotonia (HP:0001290)1.68793495
164Aplasia/Hypoplasia of the sternum (HP:0006714)1.68693648
165Subacute progressive viral hepatitis (HP:0006572)1.68420944
166Bifid tongue (HP:0010297)1.68285184
167Muscle fiber inclusion bodies (HP:0100299)1.67318844
168Biconcave vertebral bodies (HP:0004586)1.67282100
169Atresia of the external auditory canal (HP:0000413)1.66976787
170Centrally nucleated skeletal muscle fibers (HP:0003687)1.65854027
171Cupped ribs (HP:0000887)1.64734870
172Entropion (HP:0000621)1.63665080
173Abnormality of the fingertips (HP:0001211)1.63096374
174Distal lower limb muscle weakness (HP:0009053)1.62907315
175Cubitus valgus (HP:0002967)1.62628832
176Insomnia (HP:0100785)1.62202827
177Aneurysm (HP:0002617)1.62171066
178Bladder neoplasm (HP:0009725)1.61891781
179Bladder carcinoma (HP:0002862)1.61891781
180Metaphyseal cupping (HP:0003021)1.61252380
181Deformed tarsal bones (HP:0008119)1.61144577
182Hyperextensible skin (HP:0000974)1.60889635
183Transitional cell carcinoma of the bladder (HP:0006740)1.60504150
184Cervical subluxation (HP:0003308)1.60439386
185Overgrowth (HP:0001548)1.59169531
186Rhizomelia (HP:0008905)1.58134072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.96431239
2ERN13.35126517
3GRK53.28743476
4GRK63.00508012
5PRPF4B2.79078064
6TTK2.60093188
7IRAK32.49481373
8TYRO32.45037097
9STK102.19560357
10PKN22.17518858
11SMG12.10829740
12MAP3K102.02227981
13NEK11.90140465
14EPHA21.84546712
15TRIB31.81698491
16CSF1R1.81173407
17TGFBR21.78706409
18ALK1.74363742
19TTN1.71665638
20EIF2AK11.70368979
21RIPK11.59921203
22MAP3K141.59014132
23STK38L1.50372847
24MAPK71.47644272
25STK241.44075275
26GRK11.39383190
27FGFR41.37768395
28CDC71.37268993
29MAP3K131.35977909
30PDGFRA1.32449948
31LATS21.30707918
32PAK41.30620390
33NEK21.29740952
34MATK1.29036311
35FGFR31.27291365
36KSR11.25217920
37EEF2K1.22059783
38NEK91.20946859
39CDK71.20725432
40CLK11.14885817
41LATS11.12843595
42RPS6KB21.10893760
43MAP3K71.10557666
44MOS1.09851956
45CAMK41.07716554
46TAOK21.05229631
47CHEK21.02640796
48MAP3K91.00416141
49KSR20.99254359
50MAP2K30.98138448
51* MTOR0.96885908
52PLK10.96745311
53BMX0.95738154
54TRPM70.95430339
55CHEK10.95100031
56PRKG20.94871042
57MAP2K40.93944455
58GRK70.91438252
59CDK40.91399312
60MARK20.90037681
61YES10.89825722
62NTRK10.89553834
63ADRBK20.89173473
64CAMK1G0.87198284
65STK30.84554209
66CDC42BPA0.82518633
67TAOK10.80980901
68AKT20.80852093
69BRAF0.80115197
70PBK0.79937079
71SCYL20.77119325
72MAP3K60.73236345
73ICK0.72940702
74MST1R0.72248018
75MET0.72168546
76CSK0.71528557
77RAF10.71057693
78HIPK20.68902896
79STK380.68644842
80CDK60.68108962
81PTK20.67392004
82DMPK0.66116696
83SGK30.66095260
84EIF2AK30.66013498
85TSSK60.64661270
86CDK20.64623397
87MAP3K80.63609989
88ERBB40.62747296
89CAMK1D0.61743968
90PDK40.61291918
91PDK30.61291918
92TAF10.60306469
93BRSK20.58403194
94PTK60.58257804
95MAP3K20.58184557
96ATM0.57340594
97JAK30.55990280
98EPHB10.55875657
99FLT30.53963101
100SIK10.52733060
101AKT30.52700417
102MAP3K10.51621553
103CSNK1E0.50839346
104BRD40.50771292
105MKNK10.49823135
106JAK10.49130332
107PASK0.48622830
108IRAK20.48564733
109AURKB0.48445104
110ADRBK10.48222298
111DDR20.46012787
112ZAP700.45484603
113SRPK10.45143736
114WEE10.44663825
115MAPK100.44362608
116MAP3K30.43848798
117CDK90.43253645
118PAK20.42831988
119NME20.41904706
120IRAK40.41593214
121FGFR10.41528463
122CDK80.41271345
123RPS6KL10.40950054
124RPS6KC10.40950054
125FGR0.39745143
126PRKAA10.38753196
127CSNK1D0.38371338
128PAK30.38327018
129PAK60.37403009
130CDK10.36715296
131LRRK20.36455414
132RET0.36152920
133PDGFRB0.35882693
134MAPK120.32203764
135MELK0.31981911
136MAPK140.31943599
137GSK3B0.31202474
138MAPK10.31124297
139ATR0.30877248
140PRKCI0.29704181
141GSK3A0.29386009
142STK40.28258451
143ITK0.28201999
144PIK3CA0.27716776
145JAK20.26615334

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.15047329
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.11376226
3Vitamin B6 metabolism_Homo sapiens_hsa007502.97061915
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84111112
5mTOR signaling pathway_Homo sapiens_hsa041502.48445112
6Fructose and mannose metabolism_Homo sapiens_hsa000512.47878698
7RNA transport_Homo sapiens_hsa030131.92013190
8Thyroid cancer_Homo sapiens_hsa052161.86588565
9Central carbon metabolism in cancer_Homo sapiens_hsa052301.73055062
10Galactose metabolism_Homo sapiens_hsa000521.70880580
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.69842898
12mRNA surveillance pathway_Homo sapiens_hsa030151.67199455
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.60825108
14One carbon pool by folate_Homo sapiens_hsa006701.60718052
15Nitrogen metabolism_Homo sapiens_hsa009101.58283761
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54892502
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50960630
18MicroRNAs in cancer_Homo sapiens_hsa052061.43759987
19Amoebiasis_Homo sapiens_hsa051461.42042647
20Adherens junction_Homo sapiens_hsa045201.38229178
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.34949139
22B cell receptor signaling pathway_Homo sapiens_hsa046621.32022636
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31343890
24Hepatitis B_Homo sapiens_hsa051611.31295344
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28176131
26Proteoglycans in cancer_Homo sapiens_hsa052051.26985126
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26179566
28Cell cycle_Homo sapiens_hsa041101.24707512
29Hippo signaling pathway_Homo sapiens_hsa043901.24634957
30ECM-receptor interaction_Homo sapiens_hsa045121.24232498
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23717071
32Shigellosis_Homo sapiens_hsa051311.23068264
33Lysine degradation_Homo sapiens_hsa003101.13891913
34Non-small cell lung cancer_Homo sapiens_hsa052231.13668721
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12180352
36Acute myeloid leukemia_Homo sapiens_hsa052211.10897727
37Bladder cancer_Homo sapiens_hsa052191.10728086
38Prolactin signaling pathway_Homo sapiens_hsa049171.10629294
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09960434
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09543429
41AMPK signaling pathway_Homo sapiens_hsa041521.09481199
42Small cell lung cancer_Homo sapiens_hsa052221.06962611
43Measles_Homo sapiens_hsa051621.06529732
44Influenza A_Homo sapiens_hsa051641.04140610
45TNF signaling pathway_Homo sapiens_hsa046681.03950510
46Carbon metabolism_Homo sapiens_hsa012001.02646023
47Chronic myeloid leukemia_Homo sapiens_hsa052201.02188530
48Biosynthesis of amino acids_Homo sapiens_hsa012301.02068512
49Insulin resistance_Homo sapiens_hsa049311.01380551
50Toxoplasmosis_Homo sapiens_hsa051451.01090787
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01031586
52Tight junction_Homo sapiens_hsa045301.00293996
53Basal cell carcinoma_Homo sapiens_hsa052170.98476221
54Dilated cardiomyopathy_Homo sapiens_hsa054140.95602787
55Prion diseases_Homo sapiens_hsa050200.95261715
56Salmonella infection_Homo sapiens_hsa051320.94094156
57Endometrial cancer_Homo sapiens_hsa052130.94050474
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93801696
59Dorso-ventral axis formation_Homo sapiens_hsa043200.93600727
60p53 signaling pathway_Homo sapiens_hsa041150.93370872
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92791054
62Colorectal cancer_Homo sapiens_hsa052100.92717504
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92397519
64Focal adhesion_Homo sapiens_hsa045100.91984194
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91736209
66Osteoclast differentiation_Homo sapiens_hsa043800.91127244
67VEGF signaling pathway_Homo sapiens_hsa043700.90415290
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.89870300
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89625834
70Hepatitis C_Homo sapiens_hsa051600.89420227
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.88513839
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87962171
73Leishmaniasis_Homo sapiens_hsa051400.87646876
74Viral carcinogenesis_Homo sapiens_hsa052030.86290149
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86280573
76Pathways in cancer_Homo sapiens_hsa052000.85330080
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.82834648
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82440928
79Other glycan degradation_Homo sapiens_hsa005110.82209449
80Pancreatic cancer_Homo sapiens_hsa052120.81263833
81FoxO signaling pathway_Homo sapiens_hsa040680.80609597
82HIF-1 signaling pathway_Homo sapiens_hsa040660.80267858
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79955141
84Inositol phosphate metabolism_Homo sapiens_hsa005620.79418359
85Malaria_Homo sapiens_hsa051440.78647287
86Non-homologous end-joining_Homo sapiens_hsa034500.74754659
87Legionellosis_Homo sapiens_hsa051340.74519568
88Insulin signaling pathway_Homo sapiens_hsa049100.74335493
89Rap1 signaling pathway_Homo sapiens_hsa040150.73744580
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.73460763
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73145038
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.72363326
93Glioma_Homo sapiens_hsa052140.69977167
94Choline metabolism in cancer_Homo sapiens_hsa052310.69881410
95Hedgehog signaling pathway_Homo sapiens_hsa043400.69712977
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69145876
97Mismatch repair_Homo sapiens_hsa034300.69101621
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.69042330
99Bile secretion_Homo sapiens_hsa049760.68335425
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68276106
101Viral myocarditis_Homo sapiens_hsa054160.67570157
102HTLV-I infection_Homo sapiens_hsa051660.66979807
103Selenocompound metabolism_Homo sapiens_hsa004500.66274318
104Melanoma_Homo sapiens_hsa052180.64977497
105Oocyte meiosis_Homo sapiens_hsa041140.64916888
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64608306
107TGF-beta signaling pathway_Homo sapiens_hsa043500.64386639
108Arginine biosynthesis_Homo sapiens_hsa002200.63796678
109Epstein-Barr virus infection_Homo sapiens_hsa051690.63281694
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63163792
111Apoptosis_Homo sapiens_hsa042100.62223760
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61491780
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58688345
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57046238
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.56997504
116Fatty acid biosynthesis_Homo sapiens_hsa000610.56896331
117Pentose phosphate pathway_Homo sapiens_hsa000300.56824611
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56207117
119Renal cell carcinoma_Homo sapiens_hsa052110.55453923
120Nucleotide excision repair_Homo sapiens_hsa034200.54668601
121Notch signaling pathway_Homo sapiens_hsa043300.54286141
122DNA replication_Homo sapiens_hsa030300.53433074
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53231323
124Tuberculosis_Homo sapiens_hsa051520.53144389
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49597261
126ErbB signaling pathway_Homo sapiens_hsa040120.47885055
127Herpes simplex infection_Homo sapiens_hsa051680.46163505
128Wnt signaling pathway_Homo sapiens_hsa043100.45083586
129RNA degradation_Homo sapiens_hsa030180.44627937
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43553055
131Glucagon signaling pathway_Homo sapiens_hsa049220.43080811
132T cell receptor signaling pathway_Homo sapiens_hsa046600.41941183
133Spliceosome_Homo sapiens_hsa030400.41309819
134Prostate cancer_Homo sapiens_hsa052150.41054442
135MAPK signaling pathway_Homo sapiens_hsa040100.40801126

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