OXT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.50382050
2regulation of acrosome reaction (GO:0060046)6.32787909
3positive regulation of amino acid transport (GO:0051957)6.20942187
4opioid receptor signaling pathway (GO:0038003)6.05058385
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.95585813
6regulation of female gonad development (GO:2000194)5.79272014
7protein kinase C signaling (GO:0070528)5.54125539
8regulation of meiosis I (GO:0060631)5.51802085
9inner mitochondrial membrane organization (GO:0007007)5.48655974
10energy coupled proton transport, down electrochemical gradient (GO:0015985)5.41776314
11ATP synthesis coupled proton transport (GO:0015986)5.41776314
12multicellular organism reproduction (GO:0032504)5.40032224
13male meiosis I (GO:0007141)5.33284968
14pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.32236574
15regulation of glutamate secretion (GO:0014048)5.31830736
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.18784106
17response to histamine (GO:0034776)5.09144058
18establishment of protein localization to mitochondrial membrane (GO:0090151)5.07164293
19* aggressive behavior (GO:0002118)5.04652490
20respiratory electron transport chain (GO:0022904)4.93459149
21oocyte development (GO:0048599)4.83238661
22electron transport chain (GO:0022900)4.80173004
23regulation of cytokine production involved in inflammatory response (GO:1900015)4.78925718
24regulation of DNA methylation (GO:0044030)4.76992384
25negative regulation of amino acid transport (GO:0051956)4.72304397
26chaperone-mediated protein transport (GO:0072321)4.63847689
27DNA methylation involved in gamete generation (GO:0043046)4.57428604
28neurotransmitter catabolic process (GO:0042135)4.54256942
29base-excision repair, AP site formation (GO:0006285)4.42489266
30pyrimidine nucleotide catabolic process (GO:0006244)4.40425280
31meiosis I (GO:0007127)4.39383233
32gamma-aminobutyric acid signaling pathway (GO:0007214)4.32703787
33negative regulation of reproductive process (GO:2000242)4.25074530
34positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.24890176
35positive regulation of histone H3-K4 methylation (GO:0051571)4.10237920
36regulation of protein kinase A signaling (GO:0010738)4.09457489
37protein localization to synapse (GO:0035418)4.08995475
38seminiferous tubule development (GO:0072520)4.06940219
39meiotic cell cycle (GO:0051321)4.05595892
40neuron cell-cell adhesion (GO:0007158)4.03131426
41vocalization behavior (GO:0071625)4.02199992
42phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.01804811
43reproduction (GO:0000003)4.00171620
44regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.87904074
45cerebellar Purkinje cell layer development (GO:0021680)3.86159123
46synaptic vesicle exocytosis (GO:0016079)3.85879943
47synaptic vesicle maturation (GO:0016188)3.78850780
48male meiosis (GO:0007140)3.73186968
49glycine transport (GO:0015816)3.71952730
50opsonization (GO:0008228)3.59214207
51positive regulation of meiosis (GO:0045836)3.57078162
52female gamete generation (GO:0007292)3.51582286
53positive regulation of meiotic cell cycle (GO:0051446)3.49568536
54ATP hydrolysis coupled proton transport (GO:0015991)3.48676803
55energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.48676803
56imidazole-containing compound metabolic process (GO:0052803)3.44629483
57* hyperosmotic salinity response (GO:0042538)3.43932560
58* positive regulation of amine transport (GO:0051954)3.39958378
59deoxyribonucleotide catabolic process (GO:0009264)3.38758353
60axon ensheathment in central nervous system (GO:0032291)3.38329033
61central nervous system myelination (GO:0022010)3.38329033
62mating behavior (GO:0007617)3.37365212
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.35913143
64L-phenylalanine catabolic process (GO:0006559)3.35913143
65regulation of synaptic vesicle exocytosis (GO:2000300)3.34523316
66regulation of amino acid transport (GO:0051955)3.32967589
67gonadal mesoderm development (GO:0007506)3.30741056
68layer formation in cerebral cortex (GO:0021819)3.29357276
69regulation of glutamate receptor signaling pathway (GO:1900449)3.28903927
70transmission of nerve impulse (GO:0019226)3.28443917
71regulation of short-term neuronal synaptic plasticity (GO:0048172)3.28025681
72hydrogen ion transmembrane transport (GO:1902600)3.24947831
73detection of calcium ion (GO:0005513)3.20706818
74DNA deamination (GO:0045006)3.17836797
75valine metabolic process (GO:0006573)3.16318116
76long-chain fatty acid biosynthetic process (GO:0042759)3.16307090
77axonal fasciculation (GO:0007413)3.16174014
78GTP biosynthetic process (GO:0006183)3.15863011
79pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.14116568
80activation of protein kinase A activity (GO:0034199)3.14032373
81neuron recognition (GO:0008038)3.12575734
82positive regulation of humoral immune response (GO:0002922)3.12229114
83synaptonemal complex assembly (GO:0007130)3.10782973
84endothelium development (GO:0003158)3.10398676
85deoxyribose phosphate catabolic process (GO:0046386)3.08985045
86purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.07010156
87* grooming behavior (GO:0007625)3.06988881
88maturation of SSU-rRNA (GO:0030490)3.06918183
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.06294699
90L-phenylalanine metabolic process (GO:0006558)3.06294699
91positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04669931
92ATP biosynthetic process (GO:0006754)3.04480769
93meiotic nuclear division (GO:0007126)3.04164037
94respiratory system process (GO:0003016)3.02868932
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.02287141
96fatty acid elongation (GO:0030497)3.00222939
97purine nucleoside triphosphate biosynthetic process (GO:0009145)2.99771980
98forebrain neuron differentiation (GO:0021879)2.99682485
99positive regulation of action potential (GO:0045760)2.99648045
100immunoglobulin mediated immune response (GO:0016064)2.99403639
101single fertilization (GO:0007338)2.99378102
102ribosomal small subunit assembly (GO:0000028)2.98206830
103* regulation of female receptivity (GO:0045924)2.96976008
104regulation of ARF protein signal transduction (GO:0032012)2.93741744
105presynaptic membrane organization (GO:0097090)2.92223975
106regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.92085506
107chromosome organization involved in meiosis (GO:0070192)2.91693616
108neurotransmitter-gated ion channel clustering (GO:0072578)2.91537696
109synaptonemal complex organization (GO:0070193)2.90719474
110gene silencing by RNA (GO:0031047)2.88997851
111protein localization to cilium (GO:0061512)2.88576804
112chaperone mediated protein folding requiring cofactor (GO:0051085)2.88221632
113fertilization (GO:0009566)2.88201827
114dendrite development (GO:0016358)2.87829084
115succinate metabolic process (GO:0006105)2.86966561
116* positive regulation of organic acid transport (GO:0032892)2.86309012
117regulation of beta-amyloid formation (GO:1902003)2.86054626
118toxin metabolic process (GO:0009404)2.84050499
119regulation of feeding behavior (GO:0060259)2.82057320
120UTP biosynthetic process (GO:0006228)2.81925913
121synapsis (GO:0007129)2.81550634
122retinal cone cell development (GO:0046549)2.79205349
123iron coordination entity transport (GO:1901678)2.78630185
124* female mating behavior (GO:0060180)2.77827130
125purine nucleotide salvage (GO:0032261)2.77590579
126locomotory exploration behavior (GO:0035641)2.77329846
127import into cell (GO:0098657)2.77238230
128negative regulation of macrophage differentiation (GO:0045650)2.76811919
129oxygen transport (GO:0015671)2.75281515
130ribonucleoside triphosphate biosynthetic process (GO:0009201)2.73088343
131cellular response to ammonium ion (GO:0071242)2.71105844
132presynaptic membrane assembly (GO:0097105)2.70055739
133UTP metabolic process (GO:0046051)2.69516893
134proton transport (GO:0015992)2.68916858
135hydrogen transport (GO:0006818)2.68074293
136DNA modification (GO:0006304)2.67273958
137regulation of meiosis (GO:0040020)2.67105657
138neuron remodeling (GO:0016322)2.66703442
139rRNA modification (GO:0000154)2.65910085
140binding of sperm to zona pellucida (GO:0007339)2.62991983
141meiotic cell cycle process (GO:1903046)2.62713182
142positive regulation of antigen processing and presentation (GO:0002579)2.62011577
143histone H3-K9 demethylation (GO:0033169)2.61811132
144peptidyl-arginine omega-N-methylation (GO:0035247)2.61556609
145regulation of meiotic cell cycle (GO:0051445)2.61151630
146* positive regulation of synapse assembly (GO:0051965)2.60718471
147regulation of cAMP-dependent protein kinase activity (GO:2000479)2.60703310
148gamma-aminobutyric acid transport (GO:0015812)2.57563644
149urate metabolic process (GO:0046415)2.57258970
150negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.57092948
151striatum development (GO:0021756)2.56874025
152regulation of steroid hormone secretion (GO:2000831)2.56249730
153exogenous drug catabolic process (GO:0042738)2.56212966
154exploration behavior (GO:0035640)2.56064739
155nucleotide salvage (GO:0043173)2.55596122
156adult walking behavior (GO:0007628)2.54150079
157water-soluble vitamin biosynthetic process (GO:0042364)2.53008723
158neuromuscular process controlling posture (GO:0050884)2.52778328
159regulation of histone H3-K9 methylation (GO:0051570)2.52524339
160translesion synthesis (GO:0019985)2.50912396
161dendrite morphogenesis (GO:0048813)2.49978055
162positive regulation of protein kinase C signaling (GO:0090037)2.49943398
163sperm-egg recognition (GO:0035036)2.49415697
164synapse assembly (GO:0007416)2.48695631
165regulation of amyloid precursor protein catabolic process (GO:1902991)2.48454701
166long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.48081133
167cotranslational protein targeting to membrane (GO:0006613)2.47821618
168DNA alkylation (GO:0006305)2.47445989
169DNA methylation (GO:0006306)2.47445989
170definitive hemopoiesis (GO:0060216)2.47340863
171regulation of calcium ion-dependent exocytosis (GO:0017158)2.45975938
172pseudouridine synthesis (GO:0001522)2.45392882
173regulation of histone H3-K4 methylation (GO:0051569)2.42777039
174short-chain fatty acid metabolic process (GO:0046459)2.42490677
175termination of RNA polymerase III transcription (GO:0006386)2.39691649
176transcription elongation from RNA polymerase III promoter (GO:0006385)2.39691649
177regulation of transmission of nerve impulse (GO:0051969)2.38994145
178cellular response to interferon-beta (GO:0035458)2.38343949
179viral protein processing (GO:0019082)2.34890568
180primitive streak formation (GO:0090009)2.33806662
181reciprocal DNA recombination (GO:0035825)2.33628376
182reciprocal meiotic recombination (GO:0007131)2.33628376
183methionine metabolic process (GO:0006555)2.32319324
184negative regulation of Notch signaling pathway (GO:0045746)2.31927096
185L-methionine salvage (GO:0071267)2.30271952
186L-methionine biosynthetic process (GO:0071265)2.30271952
187amino acid salvage (GO:0043102)2.30271952
188response to interferon-beta (GO:0035456)2.28923961
189negative regulation of hormone metabolic process (GO:0032351)2.28522770
190B cell mediated immunity (GO:0019724)2.27698144
191NADH dehydrogenase complex assembly (GO:0010257)2.27424675
192mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.27424675
193mitochondrial respiratory chain complex I assembly (GO:0032981)2.27424675
194mitochondrial DNA replication (GO:0006264)2.27165432
195negative regulation of retinoic acid receptor signaling pathway (GO:0048387)17.3327294
196regulation of retinoic acid receptor signaling pathway (GO:0048385)15.3783515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.09800795
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.98141584
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.93098721
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.53541678
5TAF15_26573619_Chip-Seq_HEK293_Human3.36175729
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.35701424
7IKZF1_21737484_ChIP-ChIP_HCT116_Human3.27659659
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21116127
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.18112286
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.97107917
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90425755
12GBX2_23144817_ChIP-Seq_PC3_Human2.79528038
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.76168674
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73779731
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69392125
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.66208745
17REST_21632747_ChIP-Seq_MESCs_Mouse2.64113941
18* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55182295
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51822436
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50582339
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45393217
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45329081
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.44957858
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.44957858
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.44957858
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.42994098
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.33640339
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.32738235
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31580907
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30045905
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25822679
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22134372
33NOTCH1_21737748_ChIP-Seq_TLL_Human2.21694085
34EZH2_27304074_Chip-Seq_ESCs_Mouse2.16930530
35RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15542485
36EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15542485
37REST_18959480_ChIP-ChIP_MESCs_Mouse2.14267190
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.13696602
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.13297452
40* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08231673
41JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07526522
42AR_21572438_ChIP-Seq_LNCaP_Human2.04764541
43CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03514576
44* EED_16625203_ChIP-ChIP_MESCs_Mouse2.03422590
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.98475546
46VDR_23849224_ChIP-Seq_CD4+_Human1.98017899
47FOXP3_21729870_ChIP-Seq_TREG_Human1.96145624
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96062747
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.92277313
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.86395004
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85694823
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83576594
53MYC_18940864_ChIP-ChIP_HL60_Human1.80281356
54SCL_19346495_ChIP-Seq_HPC-7_Human1.79527251
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78925666
56DROSHA_22980978_ChIP-Seq_HELA_Human1.78493491
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72857277
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71449867
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71277764
60TP53_22573176_ChIP-Seq_HFKS_Human1.70499842
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.66537231
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.66277623
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66137916
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64132565
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61074829
66IGF1R_20145208_ChIP-Seq_DFB_Human1.60394018
67NANOG_20526341_ChIP-Seq_ESCs_Human1.59657331
68IRF1_19129219_ChIP-ChIP_H3396_Human1.59470759
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59195103
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.58883139
71MYC_18555785_ChIP-Seq_MESCs_Mouse1.58600145
72P300_19829295_ChIP-Seq_ESCs_Human1.55891682
73SMAD4_21799915_ChIP-Seq_A2780_Human1.54762072
74CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.53111561
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.52875804
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.52728047
77FUS_26573619_Chip-Seq_HEK293_Human1.50050059
78* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47956897
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47366159
80RARB_27405468_Chip-Seq_BRAIN_Mouse1.46958548
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46819786
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.45618730
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42957552
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.42367272
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.40960115
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.40014476
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39889387
88ER_23166858_ChIP-Seq_MCF-7_Human1.39171200
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.38296477
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37418483
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36781680
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35534258
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.34606093
94ZNF274_21170338_ChIP-Seq_K562_Hela1.34469741
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33597382
96CIITA_25753668_ChIP-Seq_RAJI_Human1.33467434
97P300_27268052_Chip-Seq_Bcells_Human1.30779466
98SALL1_21062744_ChIP-ChIP_HESCs_Human1.27878217
99BCL6_27268052_Chip-Seq_Bcells_Human1.27481170
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27403612
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26462083
102AR_20517297_ChIP-Seq_VCAP_Human1.24316671
103EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22114198
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22042483
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20282643
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20144577
107CTCF_20526341_ChIP-Seq_ESCs_Human1.19622972
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19307827
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18945321
110RNF2_27304074_Chip-Seq_NSC_Mouse1.18057945
111VDR_22108803_ChIP-Seq_LS180_Human1.17704245
112CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17244013
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15199156
114CBX2_27304074_Chip-Seq_ESCs_Mouse1.14778647
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12379782
116JUN_21703547_ChIP-Seq_K562_Human1.11471217
117BCOR_27268052_Chip-Seq_Bcells_Human1.11282880
118TTF2_22483619_ChIP-Seq_HELA_Human1.11221343
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10830122
120GABP_19822575_ChIP-Seq_HepG2_Human1.10519840
121GATA3_21878914_ChIP-Seq_MCF-7_Human1.10431943
122THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09690429
123STAT1_20625510_ChIP-Seq_HELA_Human1.08835618
124NCOR_22424771_ChIP-Seq_293T_Human1.07851671
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07648621
126KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06610844
127HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06406911
128FOXH1_21741376_ChIP-Seq_EPCs_Human1.06246064
129TAF2_19829295_ChIP-Seq_ESCs_Human1.05513194
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05500706
131HTT_18923047_ChIP-ChIP_STHdh_Human1.05213922
132AR_25329375_ChIP-Seq_VCAP_Human1.04869239
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04508046
134NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04041712
135RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03160249
136MYC_19829295_ChIP-Seq_ESCs_Human1.02203853
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01501570
138E2F1_20622854_ChIP-Seq_HELA_Human1.01416480
139RAC3_21632823_ChIP-Seq_H3396_Human1.01199728
140TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01078473
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00984180
142P68_20966046_ChIP-Seq_HELA_Human1.00870911
143RING1B_27294783_Chip-Seq_ESCs_Mouse1.00808638
144SOX2_21211035_ChIP-Seq_LN229_Human1.00418617
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00322328
146LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99557175
147HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99230854
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99028030
149RUNX2_22187159_ChIP-Seq_PCA_Human0.98497746
150OCT4_20526341_ChIP-Seq_ESCs_Human0.98466274
151FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97318267
152SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97098094
153FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94754484
154DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93521600
155PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91838274
156* CTCF_26484167_Chip-Seq_Bcells_Mouse0.90682316
157SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90122161
158P53_21459846_ChIP-Seq_SAOS-2_Human0.90054443
159IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90034025
160CBP_20019798_ChIP-Seq_JUKART_Human0.90034025
161GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89861691
162EGR1_19032775_ChIP-ChIP_M12_Human0.89850741
163FOXH1_21741376_ChIP-Seq_ESCs_Human0.89449173
164PHF8_20622854_ChIP-Seq_HELA_Human0.88089939
165TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88066111
166CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87717153
167AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87058906
168TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86816594
169MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86716729
170FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86470166
171* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85920781
172POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85819720
173SMAD4_21741376_ChIP-Seq_EPCs_Human0.85628403
174ARNT_22903824_ChIP-Seq_MCF-7_Human0.85367499
175ERA_21632823_ChIP-Seq_H3396_Human0.84105535
176ELK1_22589737_ChIP-Seq_MCF10A_Human0.84041590
177* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83700321
178FLI1_21867929_ChIP-Seq_TH2_Mouse0.83432410
179REST_19997604_ChIP-ChIP_NEURONS_Mouse0.83073173
180PRDM14_20953172_ChIP-Seq_ESCs_Human0.82871354
181TCF4_23295773_ChIP-Seq_U87_Human0.81734275
182TAL1_26923725_Chip-Seq_HPCs_Mouse0.80324092
183AHR_22903824_ChIP-Seq_MCF-7_Human0.80306543
184RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79727778
185SOX2_16153702_ChIP-ChIP_HESCs_Human0.79430374
186LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79215062
187STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78997950
188WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78984944
189TP53_18474530_ChIP-ChIP_U2OS_Human0.78117440
190FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78087641
191RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.76443973
192STAT3_23295773_ChIP-Seq_U87_Human0.76268659
193* CTCF_27219007_Chip-Seq_Bcells_Human0.75819135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.13065909
2MP0005645_abnormal_hypothalamus_physiol4.65184347
3MP0006292_abnormal_olfactory_placode4.36371630
4MP0002138_abnormal_hepatobiliary_system3.67152143
5MP0003880_abnormal_central_pattern3.65701816
6MP0004859_abnormal_synaptic_plasticity3.62637344
7* MP0006276_abnormal_autonomic_nervous3.53166850
8MP0003635_abnormal_synaptic_transmissio3.07052594
9MP0001986_abnormal_taste_sensitivity2.91791316
10MP0001529_abnormal_vocalization2.79933980
11MP0002837_dystrophic_cardiac_calcinosis2.79487931
12MP0008877_abnormal_DNA_methylation2.71064888
13MP0003122_maternal_imprinting2.70791613
14MP0002064_seizures2.70236445
15MP0009745_abnormal_behavioral_response2.68289945
16MP0009379_abnormal_foot_pigmentation2.60997743
17MP0008875_abnormal_xenobiotic_pharmacok2.60531719
18MP0008058_abnormal_DNA_repair2.52702477
19MP0005410_abnormal_fertilization2.44372118
20MP0003690_abnormal_glial_cell2.43040682
21MP0005395_other_phenotype2.42758734
22MP0003329_amyloid_beta_deposits2.39979100
23MP0000751_myopathy2.39624863
24* MP0002063_abnormal_learning/memory/cond2.35500562
25MP0004270_analgesia2.31475213
26MP0002160_abnormal_reproductive_system2.30892385
27MP0009840_abnormal_foam_cell2.30418020
28MP0001968_abnormal_touch/_nociception2.16970476
29* MP0002572_abnormal_emotion/affect_behav2.16716089
30MP0010368_abnormal_lymphatic_system2.14986160
31MP0001929_abnormal_gametogenesis2.07349999
32* MP0001440_abnormal_grooming_behavior2.05339213
33MP0005083_abnormal_biliary_tract1.98516508
34MP0002332_abnormal_exercise_endurance1.89051126
35MP0002736_abnormal_nociception_after1.85230877
36MP0002272_abnormal_nervous_system1.85045426
37MP0001545_abnormal_hematopoietic_system1.82224227
38MP0005397_hematopoietic_system_phenotyp1.82224227
39MP0000604_amyloidosis1.82144924
40MP0005084_abnormal_gallbladder_morpholo1.78604501
41MP0002734_abnormal_mechanical_nocicepti1.77326063
42MP0002210_abnormal_sex_determination1.77132152
43MP0003252_abnormal_bile_duct1.74329639
44MP0005423_abnormal_somatic_nervous1.73893739
45MP0003693_abnormal_embryo_hatching1.71866384
46MP0001764_abnormal_homeostasis1.69809309
47MP0009046_muscle_twitch1.68942391
48MP0009780_abnormal_chondrocyte_physiolo1.66911679
49MP0000747_muscle_weakness1.66625154
50MP0003186_abnormal_redox_activity1.66585970
51MP0002822_catalepsy1.64976721
52MP0004142_abnormal_muscle_tone1.62223229
53MP0001664_abnormal_digestion1.62058467
54MP0001970_abnormal_pain_threshold1.60768733
55* MP0003699_abnormal_female_reproductive1.60605800
56MP0000653_abnormal_sex_gland1.58780255
57MP0000631_abnormal_neuroendocrine_gland1.57707198
58MP0002067_abnormal_sensory_capabilities1.57492288
59MP0005389_reproductive_system_phenotype1.57041477
60MP0004924_abnormal_behavior1.56384399
61MP0005386_behavior/neurological_phenoty1.56384399
62MP0003806_abnormal_nucleotide_metabolis1.49179563
63* MP0002557_abnormal_social/conspecific_i1.48768007
64MP0005075_abnormal_melanosome_morpholog1.44766746
65MP0001501_abnormal_sleep_pattern1.43938350
66MP0008789_abnormal_olfactory_epithelium1.43601520
67MP0001905_abnormal_dopamine_level1.43537487
68MP0001119_abnormal_female_reproductive1.41992270
69MP0004036_abnormal_muscle_relaxation1.38948264
70MP0000372_irregular_coat_pigmentation1.36069429
71MP0005379_endocrine/exocrine_gland_phen1.36018101
72MP0001145_abnormal_male_reproductive1.35932808
73MP0005085_abnormal_gallbladder_physiolo1.35472801
74MP0005499_abnormal_olfactory_system1.33671980
75MP0005394_taste/olfaction_phenotype1.33671980
76MP0003698_abnormal_male_reproductive1.33649532
77MP0006036_abnormal_mitochondrial_physio1.33313042
78MP0006035_abnormal_mitochondrial_morpho1.32352688
79MP0002733_abnormal_thermal_nociception1.30735093
80MP0003724_increased_susceptibility_to1.30700717
81MP0005464_abnormal_platelet_physiology1.30120186
82MP0000015_abnormal_ear_pigmentation1.29047787
83MP0003123_paternal_imprinting1.28852224
84MP0005670_abnormal_white_adipose1.27501051
85MP0002139_abnormal_hepatobiliary_system1.27410312
86MP0002184_abnormal_innervation1.26436733
87MP0003879_abnormal_hair_cell1.25357040
88MP0000955_abnormal_spinal_cord1.25325785
89MP0001486_abnormal_startle_reflex1.24490918
90MP0000920_abnormal_myelination1.24408610
91MP0010386_abnormal_urinary_bladder1.23941925
92MP0004858_abnormal_nervous_system1.20404940
93MP0002132_abnormal_respiratory_system1.20076784
94MP0002161_abnormal_fertility/fecundity1.17482816
95MP0005187_abnormal_penis_morphology1.16556477
96MP0000778_abnormal_nervous_system1.15277806
97MP0002066_abnormal_motor_capabilities/c1.14776499
98MP0004130_abnormal_muscle_cell1.13913987
99MP0002148_abnormal_hypersensitivity_rea1.13542308
100MP0002277_abnormal_respiratory_mucosa1.12596097
101MP0005174_abnormal_tail_pigmentation1.12104080
102MP0001666_abnormal_nutrient_absorption1.11831931
103MP0002882_abnormal_neuron_morphology1.08989188
104MP0004084_abnormal_cardiac_muscle1.08987360
105MP0005310_abnormal_salivary_gland1.08833879
106MP0005646_abnormal_pituitary_gland1.08689087
107MP0008872_abnormal_physiological_respon1.07104053
108MP0009278_abnormal_bone_marrow1.05705105
109MP0005360_urolithiasis1.05083534
110MP0003121_genomic_imprinting1.02881736
111MP0003787_abnormal_imprinting1.02719676
112MP0004883_abnormal_blood_vessel1.01965312
113MP0005058_abnormal_lysosome_morphology1.01557558
114MP0003634_abnormal_glial_cell1.01278435
115MP0005319_abnormal_enzyme/_coenzyme0.99712914
116MP0005332_abnormal_amino_acid0.98432136
117MP0002735_abnormal_chemical_nociception0.97082262
118MP0000639_abnormal_adrenal_gland0.95865822
119MP0004811_abnormal_neuron_physiology0.95292433
120MP0003950_abnormal_plasma_membrane0.94557949
121MP0004272_abnormal_basement_membrane0.94100142
122MP0005551_abnormal_eye_electrophysiolog0.93824163
123MP0003633_abnormal_nervous_system0.93169261
124MP0002396_abnormal_hematopoietic_system0.92125743
125MP0009697_abnormal_copulation0.90244094
126MP0003315_abnormal_perineum_morphology0.90126564
127MP0005164_abnormal_response_to0.88177637
128MP0003075_altered_response_to0.86429027
129MP0003631_nervous_system_phenotype0.86019460
130MP0008569_lethality_at_weaning0.85881888
131MP0004145_abnormal_muscle_electrophysio0.85386246
132MP0003632_abnormal_nervous_system0.84958368
133MP0001984_abnormal_olfaction0.84864989
134MP0002234_abnormal_pharynx_morphology0.84036565
135MP0002152_abnormal_brain_morphology0.84003955
136MP0008874_decreased_physiological_sensi0.82978948
137MP0000465_gastrointestinal_hemorrhage0.82785204
138MP0000470_abnormal_stomach_morphology0.82169980
139MP0002127_abnormal_cardiovascular_syste0.81471108
140MP0002090_abnormal_vision0.81092569
141MP0004085_abnormal_heartbeat0.80934409
142MP0005647_abnormal_sex_gland0.80616169
143MP0002876_abnormal_thyroid_physiology0.80288688
144MP0004019_abnormal_vitamin_homeostasis0.79791479
145MP0004782_abnormal_surfactant_physiolog0.78121348
146MP0010094_abnormal_chromosome_stability0.77828889
147MP0005535_abnormal_body_temperature0.76426448
148MP0002254_reproductive_system_inflammat0.76330083
149MP0002163_abnormal_gland_morphology0.75546063
150MP0004510_myositis0.74983873
151MP0002229_neurodegeneration0.74310705
152MP0005266_abnormal_metabolism0.73163087
153* MP0001502_abnormal_circadian_rhythm0.72673583
154MP0003011_delayed_dark_adaptation0.70734139
155MP0002095_abnormal_skin_pigmentation0.70344106
156MP0003137_abnormal_impulse_conducting0.67711814
157MP0000013_abnormal_adipose_tissue0.67593728
158MP0002909_abnormal_adrenal_gland0.66974883
159MP0000516_abnormal_urinary_system0.66846927
160MP0005367_renal/urinary_system_phenotyp0.66846927
161MP0005365_abnormal_bile_salt0.66828793
162* MP0002069_abnormal_eating/drinking_beha0.65743018
163MP0003890_abnormal_embryonic-extraembry0.65574276
164MP0010329_abnormal_lipoprotein_level0.64121913
165MP0000427_abnormal_hair_cycle0.63790260
166MP0003868_abnormal_feces_composition0.63667233
167MP0008469_abnormal_protein_level0.62395734
168MP0003303_peritoneal_inflammation0.61386964
169* MP0001881_abnormal_mammary_gland0.61098998
170* MP0002118_abnormal_lipid_homeostasis0.60488844
171MP0008995_early_reproductive_senescence0.59929235
172MP0001293_anophthalmia0.57612576
173MP0008775_abnormal_heart_ventricle0.56945065
174MP0000566_synostosis0.56884353
175* MP0000230_abnormal_systemic_arterial0.55786390
176MP0009643_abnormal_urine_homeostasis0.55479014
177MP0005636_abnormal_mineral_homeostasis0.52861895

Predicted human phenotypes

RankGene SetZ-score
1Atonic seizures (HP:0010819)6.15992784
2Acute necrotizing encephalopathy (HP:0006965)4.63115950
3Abnormal mitochondria in muscle tissue (HP:0008316)4.50038572
4Focal seizures (HP:0007359)4.14977760
5Febrile seizures (HP:0002373)4.01787851
6Absence seizures (HP:0002121)4.00782374
7Acute encephalopathy (HP:0006846)3.98342352
8Mitochondrial inheritance (HP:0001427)3.94095617
9Aplastic anemia (HP:0001915)3.83031401
10Progressive macrocephaly (HP:0004481)3.80151687
11Dialeptic seizures (HP:0011146)3.78371946
12Generalized tonic-clonic seizures (HP:0002069)3.65417447
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.47240542
14Male infertility (HP:0003251)3.46488336
15Myokymia (HP:0002411)3.44387903
163-Methylglutaconic aciduria (HP:0003535)3.42722241
17Stomatitis (HP:0010280)3.40819513
18Premature ovarian failure (HP:0008209)3.39875009
19Tubulointerstitial nephritis (HP:0001970)3.29849736
20Hepatocellular necrosis (HP:0001404)3.27907718
21Hypophosphatemic rickets (HP:0004912)3.25314242
22Abnormality of the corticospinal tract (HP:0002492)3.20024145
23Cerebral edema (HP:0002181)3.16777927
24Parakeratosis (HP:0001036)3.14216759
25Hypoplasia of the fovea (HP:0007750)3.13495635
26Aplasia/Hypoplasia of the fovea (HP:0008060)3.13495635
27Focal motor seizures (HP:0011153)2.97433920
28Increased CSF lactate (HP:0002490)2.97187650
29Bile duct proliferation (HP:0001408)2.96420493
30Abnormal biliary tract physiology (HP:0012439)2.96420493
31Abnormality of aromatic amino acid family metabolism (HP:0004338)2.95829102
32Attenuation of retinal blood vessels (HP:0007843)2.93747036
33Pheochromocytoma (HP:0002666)2.92457360
34Elevated erythrocyte sedimentation rate (HP:0003565)2.92403561
35Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.92035389
36Decreased central vision (HP:0007663)2.90595065
37Muscle stiffness (HP:0003552)2.89997090
38Posterior subcapsular cataract (HP:0007787)2.88974876
39Leukodystrophy (HP:0002415)2.86598638
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.86358355
41Abnormality of the fovea (HP:0000493)2.82681062
42Microvesicular hepatic steatosis (HP:0001414)2.82248356
43Muscle hypertrophy of the lower extremities (HP:0008968)2.74525025
44Aplasia/hypoplasia of the uterus (HP:0008684)2.73414685
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.69518703
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.69518703
47Abnormal eating behavior (HP:0100738)2.66728328
48Generalized aminoaciduria (HP:0002909)2.66530959
49Anhidrosis (HP:0000970)2.61732352
50Hypoplasia of the uterus (HP:0000013)2.61437363
51Abnormal rod and cone electroretinograms (HP:0008323)2.60650608
52Hypergonadotropic hypogonadism (HP:0000815)2.60230793
53Rimmed vacuoles (HP:0003805)2.58719605
54Insulin-resistant diabetes mellitus (HP:0000831)2.56098816
55Termporal pattern (HP:0011008)2.52817874
56Insidious onset (HP:0003587)2.52817874
57Pancreatic cysts (HP:0001737)2.47497786
58Delayed CNS myelination (HP:0002188)2.47308155
59Optic disc pallor (HP:0000543)2.47187380
60Abnormal ciliary motility (HP:0012262)2.46649509
61Abnormality of fatty-acid metabolism (HP:0004359)2.46501947
62Gait imbalance (HP:0002141)2.44399442
63Polyphagia (HP:0002591)2.43061664
64Hepatic necrosis (HP:0002605)2.42376798
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.42300126
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.42300126
67Ankyloglossia (HP:0010296)2.39993125
68Increased variability in muscle fiber diameter (HP:0003557)2.39988370
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.39513610
70Cerebral hemorrhage (HP:0001342)2.38652929
71Spontaneous abortion (HP:0005268)2.38423106
72Respiratory failure (HP:0002878)2.38362574
73Agitation (HP:0000713)2.37978908
74Abnormal hair whorl (HP:0010721)2.37023328
75Neurofibrillary tangles (HP:0002185)2.35655103
76Nausea (HP:0002018)2.34345423
77Abnormality of midbrain morphology (HP:0002418)2.33959269
78Molar tooth sign on MRI (HP:0002419)2.33959269
79Ragged-red muscle fibers (HP:0003200)2.33601025
80Spinal cord compression (HP:0002176)2.33163212
81Reduced antithrombin III activity (HP:0001976)2.32669118
82Delayed gross motor development (HP:0002194)2.31426136
83Neuroendocrine neoplasm (HP:0100634)2.29343385
84Short tibia (HP:0005736)2.28626255
85Generalized hypotonia (HP:0001290)2.27671130
86Cleft eyelid (HP:0000625)2.27005690
87Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.26204509
88Epileptic encephalopathy (HP:0200134)2.26018878
89Abnormality of oral frenula (HP:0000190)2.25782612
90Urethral obstruction (HP:0000796)2.24952561
91Infantile muscular hypotonia (HP:0008947)2.24444904
92Proximal tubulopathy (HP:0000114)2.22755343
93Methylmalonic acidemia (HP:0002912)2.22549040
94Short nail (HP:0001799)2.20479402
95Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20094292
96Anosmia (HP:0000458)2.18890435
97Congenital primary aphakia (HP:0007707)2.17803251
98Chromsome breakage (HP:0040012)2.17062494
99Anxiety (HP:0000739)2.16427812
100Anterior segment dysgenesis (HP:0007700)2.15927912
101Athetosis (HP:0002305)2.13510967
102Infertility (HP:0000789)2.13283885
103Oligomenorrhea (HP:0000876)2.11232780
104Skin nodule (HP:0200036)2.09970739
105Tubulointerstitial fibrosis (HP:0005576)2.09928819
106Osteomalacia (HP:0002749)2.09587969
107Abnormal protein glycosylation (HP:0012346)2.08669281
108Abnormal glycosylation (HP:0012345)2.08669281
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08669281
110Abnormal protein N-linked glycosylation (HP:0012347)2.08669281
111Impaired pain sensation (HP:0007328)2.08355025
112Abnormality of pain sensation (HP:0010832)2.08355025
113Type I transferrin isoform profile (HP:0003642)2.08170973
114Increased intramyocellular lipid droplets (HP:0012240)2.07837839
115Pancreatic fibrosis (HP:0100732)2.05084554
116Exercise intolerance (HP:0003546)2.04937419
117Myositis (HP:0100614)2.03639689
118Impaired vibration sensation in the lower limbs (HP:0002166)2.02441557
119Supernumerary spleens (HP:0009799)2.02349261
120Hypoventilation (HP:0002791)2.01931513
121Abnormality of the labia minora (HP:0012880)2.01240336
122Ketosis (HP:0001946)2.00773568
123Dysdiadochokinesis (HP:0002075)1.99659751
124Myotonia (HP:0002486)1.99321486
125Chronic hepatic failure (HP:0100626)1.99211029
126Dynein arm defect of respiratory motile cilia (HP:0012255)1.97986943
127Absent/shortened dynein arms (HP:0200106)1.97986943
128Nephrogenic diabetes insipidus (HP:0009806)1.97553293
129Nephronophthisis (HP:0000090)1.95415609
130Calf muscle hypertrophy (HP:0008981)1.94468942
131Impulsivity (HP:0100710)1.94297875
132Cerebral inclusion bodies (HP:0100314)1.93730826
133Increased serum lactate (HP:0002151)1.93090270
134Abnormality of the common coagulation pathway (HP:0010990)1.92972211
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.92702546
136Increased hepatocellular lipid droplets (HP:0006565)1.92480771
137Abnormal number of erythroid precursors (HP:0012131)1.92301600
138Glycosuria (HP:0003076)1.92231109
139Abnormality of urine glucose concentration (HP:0011016)1.92231109
140Hoarse voice (HP:0001609)1.91844576
141Loss of speech (HP:0002371)1.91240451
142Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90852627
143Lactic acidosis (HP:0003128)1.89996179
144Polydipsia (HP:0001959)1.89578528
145Abnormal drinking behavior (HP:0030082)1.89578528
146Severe muscular hypotonia (HP:0006829)1.89512942
147Visual hallucinations (HP:0002367)1.89398964
148Albinism (HP:0001022)1.89087016
149Colon cancer (HP:0003003)1.87935196
150X-linked dominant inheritance (HP:0001423)1.87484114
151Azoospermia (HP:0000027)1.86586016
152Subcapsular cataract (HP:0000523)1.86037205
153Abnormality of the heme biosynthetic pathway (HP:0010472)1.85717761
154Renal Fanconi syndrome (HP:0001994)1.84778318
155Increased muscle lipid content (HP:0009058)1.84377357
156Sensory axonal neuropathy (HP:0003390)1.83785780
157Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82742244
158Dicarboxylic aciduria (HP:0003215)1.82742244
159Abnormal respiratory epithelium morphology (HP:0012253)1.82379686
160Abnormal respiratory motile cilium morphology (HP:0005938)1.82379686
161Abnormality of skeletal muscle fiber size (HP:0012084)1.82222246
162Decreased circulating renin level (HP:0003351)1.80270651
163Vaginal atresia (HP:0000148)1.80204422
164Aplasia/Hypoplasia involving the musculature (HP:0001460)1.80052913
165Carpal bone hypoplasia (HP:0001498)1.79863935
166Genital tract atresia (HP:0001827)1.79846028
167Sensorimotor neuropathy (HP:0007141)1.79550195
168Abnormal gallbladder physiology (HP:0012438)1.78361422
169Cholecystitis (HP:0001082)1.78361422
170Thrombocytosis (HP:0001894)1.78305684
171Abnormality of glycolysis (HP:0004366)1.77961048
172Increased serum pyruvate (HP:0003542)1.77961048
173Hyperglycemia (HP:0003074)1.77776918
174Malnutrition (HP:0004395)1.76909433
175Abnormal pupillary function (HP:0007686)1.76430621
176Type II lissencephaly (HP:0007260)1.75517998
177Progressive muscle weakness (HP:0003323)1.75308558
178Reticulocytopenia (HP:0001896)1.74769935
179Status epilepticus (HP:0002133)1.74681818
180Medial flaring of the eyebrow (HP:0010747)1.74392044
181Median cleft lip (HP:0000161)1.74330138
182Morphological abnormality of the pyramidal tract (HP:0002062)1.73788531
183Abnormality of the renal cortex (HP:0011035)1.73377963
184Spastic paraparesis (HP:0002313)1.72675015
185Ankle clonus (HP:0011448)1.72189463
186Scanning speech (HP:0002168)1.69361525
187Supranuclear gaze palsy (HP:0000605)1.69202563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK25.83754845
2NTRK33.70043928
3NME13.47043377
4MAP3K123.43019561
5MAP3K43.40109789
6VRK23.14775794
7BCKDK2.84779652
8NTRK22.70944320
9TESK22.68252432
10MAP2K42.65999181
11UHMK12.57240463
12ERN12.46550195
13MAP3K132.33418915
14PAK62.26014482
15PNCK2.15094610
16MINK12.10535789
17SRPK11.99470189
18EPHA41.97716427
19NUAK11.91086183
20FLT31.84992794
21TSSK61.82846602
22KIT1.82026006
23TNK21.81165874
24CDK191.80550977
25OXSR11.78791038
26LIMK11.72785429
27MARK11.70720257
28TBK11.68905660
29STK161.68694734
30MAP2K71.66437310
31ZAK1.62183840
32TLK11.57994114
33PAK31.52779510
34FES1.50167735
35MAP4K21.43930883
36VRK11.39947754
37CAMK2A1.37327088
38TIE11.36759780
39STK391.35590867
40CASK1.35210017
41MAP3K91.32453509
42KDR1.31713590
43PRKG21.30960182
44CDK91.27723954
45NTRK11.27168020
46MST41.26578846
47ARAF1.20873472
48CDC71.20476118
49GRK11.17174418
50BMPR1B1.16702506
51NME21.15186238
52GRK71.14260513
53PHKG21.12039231
54PHKG11.12039231
55CDK51.06648341
56JAK31.06098891
57PBK1.00258982
58CSNK1G20.97083341
59MAP2K60.96804878
60PINK10.95679916
61ADRBK10.95653113
62DAPK20.95171678
63PTK2B0.92678280
64PRKCI0.92407428
65CAMK2G0.92375226
66PIK3CG0.91788807
67CAMK2B0.89735221
68TRIM280.85972985
69CLK10.84504524
70CDK70.83968492
71MAPK150.83760015
72ROCK20.83244019
73MAPKAPK50.81848638
74MAPK130.81679127
75ERBB40.80527209
76MAP3K110.79567178
77IKBKE0.78707518
78CAMK2D0.77734185
79MAP3K20.76707560
80SCYL20.76661006
81MAP3K50.73940730
82AKT20.73185332
83FYN0.69866011
84PKN10.69436964
85CAMK10.69021335
86CHEK20.68949376
87PLK10.67976629
88PRKCH0.67537928
89CSNK1G30.67168622
90PRKCE0.67037706
91RPS6KA20.67009245
92SRC0.66358531
93CSF1R0.65074152
94FER0.63926198
95IKBKB0.62735962
96CCNB10.62026682
97MAPK110.61214899
98MAP4K10.60704083
99TTN0.60490504
100PRKCG0.59477301
101RPS6KA30.59162113
102DYRK20.58288410
103CSNK1E0.57627219
104IRAK20.57375264
105MAP2K20.57356180
106TAOK30.55999066
107AURKB0.55275284
108PRKCB0.55050905
109ATR0.55009402
110RPS6KB20.54804284
111MAPKAPK30.54654514
112PRKG10.54575938
113RPS6KA50.54394068
114GRK50.53895201
115PRKACA0.53813955
116PIM10.53064623
117RPS6KL10.52558184
118RPS6KC10.52558184
119PRKCA0.51879512
120PRKACG0.51355352
121CDK140.49396457
122WNK40.49172696
123BCR0.49134723
124NEK60.49000248
125LATS20.48705895
126PRKD10.48093528
127CSNK1A1L0.45768699
128SYK0.45583580
129EIF2AK30.44855726
130KSR20.43764763
131ILK0.43491529
132LRRK20.43157529
133PAK10.42076293
134PIM20.41107452
135CSNK2A20.40914966
136EIF2AK20.40726729
137PAK20.40347246
138BRAF0.40256444
139PLK30.40163141
140TXK0.39988847
141PDK20.38993698
142DAPK10.38614534
143LMTK20.38139733
144PDK30.37959663
145PDK40.37959663
146CDK150.37687158
147RAF10.37241135
148CDK180.37138197
149PRKCQ0.36791085
150TNIK0.36666586
151CSNK2A10.36475645
152AURKA0.35971141
153STK30.35731372
154TTK0.35429109
155MAP3K10.34119180
156ABL20.33516070
157GRK60.32594374
158CSNK1D0.32500549
159WNK30.32415233
160RET0.32353825
161STK380.32342254
162MOS0.31905344
163ATM0.31653957
164TEC0.31291862
165DAPK30.30641239
166CSNK1G10.30366538
167RPS6KA60.30147415
168LCK0.29079732

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.52313875
2Parkinsons disease_Homo sapiens_hsa050123.52117195
3Nicotine addiction_Homo sapiens_hsa050333.33866745
4Alzheimers disease_Homo sapiens_hsa050103.15366232
5Base excision repair_Homo sapiens_hsa034103.10683114
6Basal transcription factors_Homo sapiens_hsa030222.75235028
7Asthma_Homo sapiens_hsa053102.68296264
8GABAergic synapse_Homo sapiens_hsa047272.59882902
9Huntingtons disease_Homo sapiens_hsa050162.51162600
10Cardiac muscle contraction_Homo sapiens_hsa042602.45031772
11RNA polymerase_Homo sapiens_hsa030202.40006706
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27582601
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.23516293
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.16647926
15Synaptic vesicle cycle_Homo sapiens_hsa047212.15447720
16Collecting duct acid secretion_Homo sapiens_hsa049662.12652816
17Morphine addiction_Homo sapiens_hsa050322.02416866
18Olfactory transduction_Homo sapiens_hsa047401.98880124
19Allograft rejection_Homo sapiens_hsa053301.92439077
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90900263
21Peroxisome_Homo sapiens_hsa041461.90169374
22Folate biosynthesis_Homo sapiens_hsa007901.89299620
23Autoimmune thyroid disease_Homo sapiens_hsa053201.85228350
24Vibrio cholerae infection_Homo sapiens_hsa051101.83676169
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80967915
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78738276
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.78591845
28Circadian entrainment_Homo sapiens_hsa047131.75619676
29Sulfur metabolism_Homo sapiens_hsa009201.74252714
30Graft-versus-host disease_Homo sapiens_hsa053321.71756470
31Protein export_Homo sapiens_hsa030601.70610102
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.67462299
33Renin secretion_Homo sapiens_hsa049241.66356166
34Homologous recombination_Homo sapiens_hsa034401.65629499
35Fatty acid elongation_Homo sapiens_hsa000621.62108475
36Ribosome_Homo sapiens_hsa030101.59679552
37Ovarian steroidogenesis_Homo sapiens_hsa049131.58654806
38Long-term potentiation_Homo sapiens_hsa047201.58144586
39Mismatch repair_Homo sapiens_hsa034301.55146120
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52440773
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51927043
42Caffeine metabolism_Homo sapiens_hsa002321.48017106
43Fanconi anemia pathway_Homo sapiens_hsa034601.47165602
44Glutamatergic synapse_Homo sapiens_hsa047241.47075638
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.44776396
46Long-term depression_Homo sapiens_hsa047301.44677345
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41067090
48Salivary secretion_Homo sapiens_hsa049701.39915536
49Butanoate metabolism_Homo sapiens_hsa006501.37848541
50RNA transport_Homo sapiens_hsa030131.36604190
51Linoleic acid metabolism_Homo sapiens_hsa005911.34684433
52Amphetamine addiction_Homo sapiens_hsa050311.32891959
53DNA replication_Homo sapiens_hsa030301.31526095
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30275545
55Selenocompound metabolism_Homo sapiens_hsa004501.30166195
56RNA degradation_Homo sapiens_hsa030181.28526436
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28192007
58Proteasome_Homo sapiens_hsa030501.27676167
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27621589
60Taste transduction_Homo sapiens_hsa047421.27549079
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26200297
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23181184
63Pyruvate metabolism_Homo sapiens_hsa006201.21142836
64Serotonergic synapse_Homo sapiens_hsa047261.21066745
65Arachidonic acid metabolism_Homo sapiens_hsa005901.20235080
66Regulation of autophagy_Homo sapiens_hsa041401.18541883
67SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17216553
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16757639
69Arginine biosynthesis_Homo sapiens_hsa002201.15976439
70Dopaminergic synapse_Homo sapiens_hsa047281.15641183
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13859678
72Retinol metabolism_Homo sapiens_hsa008301.11946525
73Pyrimidine metabolism_Homo sapiens_hsa002401.11500034
74Insulin secretion_Homo sapiens_hsa049111.09889651
75Nitrogen metabolism_Homo sapiens_hsa009101.09306962
76Antigen processing and presentation_Homo sapiens_hsa046121.08319189
77Gastric acid secretion_Homo sapiens_hsa049711.07682404
78Propanoate metabolism_Homo sapiens_hsa006401.05021260
79Purine metabolism_Homo sapiens_hsa002301.03025362
80Cholinergic synapse_Homo sapiens_hsa047250.99473612
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99257647
82Spliceosome_Homo sapiens_hsa030400.97468906
83Glutathione metabolism_Homo sapiens_hsa004800.97083495
84Cocaine addiction_Homo sapiens_hsa050300.96712615
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.96565106
86Herpes simplex infection_Homo sapiens_hsa051680.96044549
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95368336
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.91337608
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90184047
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90034433
91Systemic lupus erythematosus_Homo sapiens_hsa053220.89106024
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88467101
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87590252
94Estrogen signaling pathway_Homo sapiens_hsa049150.86003447
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85949918
96Tyrosine metabolism_Homo sapiens_hsa003500.84952702
97GnRH signaling pathway_Homo sapiens_hsa049120.81791512
98Oocyte meiosis_Homo sapiens_hsa041140.80505946
99Staphylococcus aureus infection_Homo sapiens_hsa051500.80049208
100Calcium signaling pathway_Homo sapiens_hsa040200.80016751
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.79648905
102Thyroid hormone synthesis_Homo sapiens_hsa049180.79348133
103One carbon pool by folate_Homo sapiens_hsa006700.78904068
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78467163
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.77753003
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75200655
107* Oxytocin signaling pathway_Homo sapiens_hsa049210.73547336
108Non-homologous end-joining_Homo sapiens_hsa034500.73509126
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71066652
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70907258
111Cell cycle_Homo sapiens_hsa041100.69579535
112Phagosome_Homo sapiens_hsa041450.69574920
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69529423
114Bile secretion_Homo sapiens_hsa049760.67745017
115Nucleotide excision repair_Homo sapiens_hsa034200.66986029
116Gap junction_Homo sapiens_hsa045400.65878180
117p53 signaling pathway_Homo sapiens_hsa041150.65667868
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65564168
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63612681
120Rheumatoid arthritis_Homo sapiens_hsa053230.63587683
121Axon guidance_Homo sapiens_hsa043600.62870372
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61754623
123Fat digestion and absorption_Homo sapiens_hsa049750.60177208
124Fatty acid metabolism_Homo sapiens_hsa012120.59937774
125Dorso-ventral axis formation_Homo sapiens_hsa043200.57506051
126beta-Alanine metabolism_Homo sapiens_hsa004100.56240277
127Vitamin digestion and absorption_Homo sapiens_hsa049770.53781067
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52459749
129ErbB signaling pathway_Homo sapiens_hsa040120.51816229
130mRNA surveillance pathway_Homo sapiens_hsa030150.51189258
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51091282
132Leishmaniasis_Homo sapiens_hsa051400.50527430
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49770665
134Carbon metabolism_Homo sapiens_hsa012000.49622073
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48036931
136Dilated cardiomyopathy_Homo sapiens_hsa054140.47239964
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47172120
138Tryptophan metabolism_Homo sapiens_hsa003800.42887968
139Melanogenesis_Homo sapiens_hsa049160.42426008
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41743766
141Prion diseases_Homo sapiens_hsa050200.40807778
142Fatty acid biosynthesis_Homo sapiens_hsa000610.39928261
143Primary immunodeficiency_Homo sapiens_hsa053400.39610614
144Glucagon signaling pathway_Homo sapiens_hsa049220.39285909
145Renal cell carcinoma_Homo sapiens_hsa052110.39261519
146Type I diabetes mellitus_Homo sapiens_hsa049400.38512034
147Glycerolipid metabolism_Homo sapiens_hsa005610.38402081
148Phototransduction_Homo sapiens_hsa047440.37259755
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37196963
150Fatty acid degradation_Homo sapiens_hsa000710.36020171
151Phenylalanine metabolism_Homo sapiens_hsa003600.35370012
152Complement and coagulation cascades_Homo sapiens_hsa046100.33731120
153Metabolic pathways_Homo sapiens_hsa011000.33612476
154Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33190689
155African trypanosomiasis_Homo sapiens_hsa051430.32099186
156cAMP signaling pathway_Homo sapiens_hsa040240.31906728
157Pancreatic secretion_Homo sapiens_hsa049720.29995873
158Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29941871
159Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29816487
160Glycerophospholipid metabolism_Homo sapiens_hsa005640.28963745
161Chemical carcinogenesis_Homo sapiens_hsa052040.28891360
162Ether lipid metabolism_Homo sapiens_hsa005650.27397934
163Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27208822
164PPAR signaling pathway_Homo sapiens_hsa033200.24911490

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