OXTR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.45107670
2response to dietary excess (GO:0002021)6.15910077
3low-density lipoprotein particle clearance (GO:0034383)5.96909428
4endocardial cushion development (GO:0003197)5.57896594
5triglyceride catabolic process (GO:0019433)4.90158955
6sequestering of extracellular ligand from receptor (GO:0035581)4.87297640
7chondrocyte proliferation (GO:0035988)4.79248919
8type B pancreatic cell proliferation (GO:0044342)4.73446822
9negative regulation of osteoblast proliferation (GO:0033689)4.56479972
10skin morphogenesis (GO:0043589)4.55581416
11regulation of sequestering of triglyceride (GO:0010889)4.50891733
12endodermal cell differentiation (GO:0035987)4.50819386
13regulation of gonadotropin secretion (GO:0032276)4.49860182
14negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)4.45858756
15kidney mesenchyme development (GO:0072074)4.45641061
16cell migration involved in sprouting angiogenesis (GO:0002042)4.45445609
17cell migration involved in heart development (GO:0060973)4.43085570
18acylglycerol catabolic process (GO:0046464)4.43031034
19neutral lipid catabolic process (GO:0046461)4.43031034
20white fat cell differentiation (GO:0050872)4.42192725
21cell adhesion mediated by integrin (GO:0033627)4.30354726
22negative regulation of axon extension involved in axon guidance (GO:0048843)4.21285069
23cellular response to vitamin (GO:0071295)4.13240799
24bone trabecula formation (GO:0060346)4.10322718
25positive regulation of endothelial cell apoptotic process (GO:2000353)4.00828775
26pericardium development (GO:0060039)3.99285187
27regulation of transforming growth factor beta1 production (GO:0032908)3.98658374
28hypotonic response (GO:0006971)3.97818898
29substrate-dependent cell migration (GO:0006929)3.95225822
30brown fat cell differentiation (GO:0050873)3.94457147
31ovulation from ovarian follicle (GO:0001542)3.85795949
32negative regulation of smooth muscle cell migration (GO:0014912)3.83971288
33metanephric mesenchyme development (GO:0072075)3.82475857
34positive regulation of fibroblast migration (GO:0010763)3.81682365
35positive regulation of blood vessel endothelial cell migration (GO:0043536)3.77978313
36lipid particle organization (GO:0034389)3.76355037
37endothelial cell morphogenesis (GO:0001886)3.75432219
38extracellular regulation of signal transduction (GO:1900115)3.74691546
39extracellular negative regulation of signal transduction (GO:1900116)3.74691546
40regulation of cAMP-dependent protein kinase activity (GO:2000479)3.73377584
41adult feeding behavior (GO:0008343)3.67290250
42extracellular matrix assembly (GO:0085029)3.67032059
43COPI coating of Golgi vesicle (GO:0048205)3.62527207
44Golgi transport vesicle coating (GO:0048200)3.62527207
45heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.61530633
46negative regulation of nitric-oxide synthase activity (GO:0051001)3.58974367
47regulation of integrin-mediated signaling pathway (GO:2001044)3.57268304
48cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.55682482
49virion attachment to host cell (GO:0019062)3.51572580
50adhesion of symbiont to host cell (GO:0044650)3.51572580
51negative regulation of axon guidance (GO:1902668)3.47686267
52glycerolipid catabolic process (GO:0046503)3.43398240
53negative regulation of embryonic development (GO:0045992)3.43024363
54negative regulation of BMP signaling pathway (GO:0030514)3.42348807
55extracellular fibril organization (GO:0043206)3.41003659
56negative regulation of JUN kinase activity (GO:0043508)3.39636156
57positive regulation of protein autophosphorylation (GO:0031954)3.39289095
58anterior/posterior axis specification, embryo (GO:0008595)3.36469782
59cellular response to leptin stimulus (GO:0044320)3.36124364
60valine metabolic process (GO:0006573)3.35967783
61neural crest cell development (GO:0014032)3.35423504
62response to magnesium ion (GO:0032026)3.34332450
63negative regulation of catenin import into nucleus (GO:0035414)3.33916125
64estrogen biosynthetic process (GO:0006703)3.32370978
65positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.32334060
66collagen metabolic process (GO:0032963)3.32087122
67activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.32053828
68negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.31873696
69regulation of osteoblast proliferation (GO:0033688)3.31862767
70planar cell polarity pathway involved in neural tube closure (GO:0090179)3.31731875
71mesenchymal-epithelial cell signaling (GO:0060638)3.25836415
72sprouting angiogenesis (GO:0002040)3.21537091
73dermatan sulfate biosynthetic process (GO:0030208)3.20122735
74lipid storage (GO:0019915)3.19759865
75response to leptin (GO:0044321)3.19598606
76blood vessel endothelial cell migration (GO:0043534)3.19418294
77negative regulation of stem cell proliferation (GO:2000647)3.17017196
78stress fiber assembly (GO:0043149)3.16853097
79cellular response to vitamin D (GO:0071305)3.16063226
80hyaluronan catabolic process (GO:0030214)3.15495101
81cell-substrate junction assembly (GO:0007044)3.15404650
82negative regulation of leukocyte chemotaxis (GO:0002689)3.11996647
83positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.11225985
84peptide hormone processing (GO:0016486)3.10481702
85substrate adhesion-dependent cell spreading (GO:0034446)3.10412799
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.09992763
87regulation of axon extension involved in axon guidance (GO:0048841)3.08865762
88collagen catabolic process (GO:0030574)3.06868989
89positive regulation of osteoblast proliferation (GO:0033690)3.06608184
90protein localization to endosome (GO:0036010)3.06146114
91dermatan sulfate metabolic process (GO:0030205)3.05491907
92chondrocyte development (GO:0002063)3.04513973
93basement membrane organization (GO:0071711)3.03662781
94negative regulation of fatty acid transport (GO:2000192)3.02721852
95multicellular organismal macromolecule metabolic process (GO:0044259)3.01323709
96negative regulation of bone remodeling (GO:0046851)3.01238164
97biotin metabolic process (GO:0006768)3.00402999
98negative regulation of protein autophosphorylation (GO:0031953)2.99683046
99negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.98208334
100fibril organization (GO:0097435)2.97710478
101regulation of glycogen (starch) synthase activity (GO:2000465)2.97568413
102adhesion of symbiont to host (GO:0044406)2.97478293
103smooth muscle tissue development (GO:0048745)2.97477026
104regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.95929741
105positive regulation of vesicle fusion (GO:0031340)2.95498936
106regulation of cholesterol storage (GO:0010885)2.92837531
107triglyceride biosynthetic process (GO:0019432)2.91027610
108positive regulation of endothelial cell migration (GO:0010595)2.89315509
109negative regulation of amino acid transport (GO:0051956)2.87881688
110vascular endothelial growth factor signaling pathway (GO:0038084)2.87210164
111lymphangiogenesis (GO:0001946)2.86840891
112transcytosis (GO:0045056)2.86064583
113multicellular organismal metabolic process (GO:0044236)2.85739082
114fatty acid transmembrane transport (GO:1902001)2.85469159
115cell-substrate adherens junction assembly (GO:0007045)2.85421399
116focal adhesion assembly (GO:0048041)2.85421399
117glycine transport (GO:0015816)2.84723757
118adherens junction assembly (GO:0034333)2.83160779
119membrane raft organization (GO:0031579)2.82963782
120neutral lipid biosynthetic process (GO:0046460)2.82383303
121acylglycerol biosynthetic process (GO:0046463)2.82383303
122long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.81188343
123regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.79986717
124long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.79722906
125actin filament depolymerization (GO:0030042)2.78701745
126protein heterotrimerization (GO:0070208)2.77912223
127response to vitamin E (GO:0033197)2.76439524
128glomerular basement membrane development (GO:0032836)2.76135736
129insulin secretion (GO:0030073)2.75334567
130muscle cell migration (GO:0014812)2.75332904
131positive regulation of axon extension (GO:0045773)2.75052948
132multicellular organismal catabolic process (GO:0044243)2.74801228
133regulation of axon guidance (GO:1902667)2.74468808
134gland morphogenesis (GO:0022612)2.74401480
135atrioventricular valve morphogenesis (GO:0003181)2.74301771
136endocytic recycling (GO:0032456)2.74231450
137glomerular epithelial cell development (GO:0072310)2.73754328
138positive regulation of macrophage activation (GO:0043032)2.73001468
139wound healing, spreading of cells (GO:0044319)2.72815488
140heparan sulfate proteoglycan metabolic process (GO:0030201)2.72288402
141positive regulation of collagen biosynthetic process (GO:0032967)2.72272651
142nitric oxide mediated signal transduction (GO:0007263)2.69900530
143positive regulation of steroid hormone secretion (GO:2000833)2.64936373
144retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.64918299
145detection of molecule of bacterial origin (GO:0032490)2.62539773
146detection of calcium ion (GO:0005513)2.61751247
147L-serine transport (GO:0015825)2.61711725
148positive regulation of macrophage cytokine production (GO:0060907)2.61185184
149cellular response to epinephrine stimulus (GO:0071872)2.60142551
150regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.59864639
151retina vasculature morphogenesis in camera-type eye (GO:0061299)2.59648931
152toxin metabolic process (GO:0009404)2.59549625
153positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.58947760
154positive regulation of glomerulus development (GO:0090193)2.58523903
155L-alpha-amino acid transmembrane transport (GO:1902475)2.58503099
156regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.57572321
157* eating behavior (GO:0042755)2.54701208
158positive regulation of calcium ion import (GO:0090280)2.53605996
159fatty-acyl-CoA biosynthetic process (GO:0046949)2.53208011
160regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50185807
161adrenergic receptor signaling pathway (GO:0071875)2.48498739
162activation of protein kinase A activity (GO:0034199)2.48460918
163growth hormone receptor signaling pathway (GO:0060396)2.48042647
164pattern specification involved in kidney development (GO:0061004)2.47714067
165regulation of non-canonical Wnt signaling pathway (GO:2000050)2.47369160
166regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.46920720
167regulation of endocrine process (GO:0044060)2.45666372
168negative regulation of macrophage differentiation (GO:0045650)2.42504375
169cellular response to growth hormone stimulus (GO:0071378)2.42239277
170succinate metabolic process (GO:0006105)2.42150038
171negative regulation of execution phase of apoptosis (GO:1900118)2.41267954
172regulation of steroid hormone secretion (GO:2000831)2.40931173
173regulation of female gonad development (GO:2000194)2.38146262
174proline transport (GO:0015824)2.38141341
175insulin-like growth factor receptor signaling pathway (GO:0048009)2.37838711
176cellular response to lithium ion (GO:0071285)2.37805314
177positive regulation of insulin secretion (GO:0032024)2.37137398
178positive regulation of cellular response to insulin stimulus (GO:1900078)2.36027415
179alanine transport (GO:0032328)2.35086309
180carnitine shuttle (GO:0006853)2.34246708
181response to lipoprotein particle (GO:0055094)2.33454584
182regulation of amino acid transport (GO:0051955)2.33064176
183peptide hormone secretion (GO:0030072)2.31762802
184peptide secretion (GO:0002790)2.31648281
185fatty-acyl-CoA metabolic process (GO:0035337)2.29528019
186regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.29179466
187glycerol metabolic process (GO:0006071)2.28920520
188thioester biosynthetic process (GO:0035384)2.28721582
189acyl-CoA biosynthetic process (GO:0071616)2.28721582
190iron ion import (GO:0097286)2.28679159
191regulation of insulin secretion (GO:0050796)2.27683508
192positive regulation of fatty acid oxidation (GO:0046321)2.27644268
193positive regulation of nitric-oxide synthase activity (GO:0051000)2.26902247
194positive regulation of insulin receptor signaling pathway (GO:0046628)2.26615223
195oligosaccharide biosynthetic process (GO:0009312)2.25749371
196response to epinephrine (GO:0071871)2.24999222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.82182293
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.92380278
3WT1_19549856_ChIP-ChIP_CCG9911_Human3.72067210
4* BRD4_25478319_ChIP-Seq_HGPS_Human3.63761100
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.59816300
6GBX2_23144817_ChIP-Seq_PC3_Human3.22717374
7* CJUN_26792858_Chip-Seq_BT549_Human2.56691650
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53225355
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.51161576
10* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48732585
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48628410
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45974267
13RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.43321723
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39988495
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.36504393
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34640409
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31844803
18EZH2_22144423_ChIP-Seq_EOC_Human2.26594639
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.17944489
20TP53_16413492_ChIP-PET_HCT116_Human2.16232505
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14426578
22* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08858676
23* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08858676
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07391280
25* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04534968
26* EZH2_27304074_Chip-Seq_ESCs_Mouse1.99945027
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.97396340
28* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97245753
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91854639
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90299014
31* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87545185
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77638273
33* PIAS1_25552417_ChIP-Seq_VCAP_Human1.77625805
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.72299099
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69871006
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69671809
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69671809
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69510265
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.69215388
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.67628263
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67285814
42JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61919866
43CLOCK_20551151_ChIP-Seq_293T_Human1.61560866
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60650304
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.60447981
46JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59116368
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58988924
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.58772966
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58307401
50* EZH2_27294783_Chip-Seq_ESCs_Mouse1.57155933
51* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57009259
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54566745
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53779273
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52880519
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52435727
56DROSHA_22980978_ChIP-Seq_HELA_Human1.51708232
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50671866
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50246988
59PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.48701423
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48181514
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47266344
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46848232
63SMAD4_21799915_ChIP-Seq_A2780_Human1.43792755
64P300_19829295_ChIP-Seq_ESCs_Human1.42180893
65SMC1_22415368_ChIP-Seq_MEFs_Mouse1.41643551
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41532105
67IGF1R_20145208_ChIP-Seq_DFB_Human1.41142927
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.40328562
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38837086
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37886987
71AR_21572438_ChIP-Seq_LNCaP_Human1.35075928
72TP53_22127205_ChIP-Seq_IMR90_Human1.33006455
73AR_25329375_ChIP-Seq_VCAP_Human1.32011878
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31834050
75REST_21632747_ChIP-Seq_MESCs_Mouse1.31613627
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.31376922
77MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.31293697
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29314595
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27995028
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27379264
81ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26558163
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25764435
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25166994
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.23760293
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22914020
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22338992
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.21496684
88* SA1_22415368_ChIP-Seq_MEFs_Mouse1.20097752
89STAT3_23295773_ChIP-Seq_U87_Human1.19498315
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18229900
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17299875
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17143885
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17134592
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.16731529
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.16141312
96TP53_23651856_ChIP-Seq_MEFs_Mouse1.15698250
97AHR_22903824_ChIP-Seq_MCF-7_Human1.15654601
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15152554
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.14947691
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.14399100
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13518999
102ISL1_27105846_Chip-Seq_CPCs_Mouse1.13476830
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12335875
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12168267
105TP63_23658742_ChIP-Seq_EP156T_Human1.11605883
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10979156
107TP53_20018659_ChIP-ChIP_R1E_Mouse1.09920326
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09538621
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07412015
110AR_21909140_ChIP-Seq_LNCAP_Human1.06677982
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05964427
112SMAD3_21741376_ChIP-Seq_HESCs_Human1.05457828
113ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05160324
114PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04211316
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04135485
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.04116478
117* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03571199
118SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03486231
119TP53_18474530_ChIP-ChIP_U2OS_Human1.03458270
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03111913
121REST_18959480_ChIP-ChIP_MESCs_Mouse1.02788432
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01760856
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01474306
124ER_23166858_ChIP-Seq_MCF-7_Human1.01222201
125ESR2_21235772_ChIP-Seq_MCF-7_Human1.00444382
126CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00352790
127TAF15_26573619_Chip-Seq_HEK293_Human0.99977650
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99772755
129AR_19668381_ChIP-Seq_PC3_Human0.99316347
130* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98648298
131RUNX2_22187159_ChIP-Seq_PCA_Human0.98373102
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98242742
133RXR_22108803_ChIP-Seq_LS180_Human0.97257108
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97160691
135TCF4_23295773_ChIP-Seq_U87_Human0.96253473
136BCAT_22108803_ChIP-Seq_LS180_Human0.95850202
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.95843078
138TCF4_22108803_ChIP-Seq_LS180_Human0.94959236
139SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94490411
140NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94367870
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94367870
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.93730847
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.93730847
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.93164896
145NFI_21473784_ChIP-Seq_ESCs_Mouse0.92656365
146NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92401636
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92057968
148SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91810129
149FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91554638
150* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.91176267
151NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90938874
152* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90834793
153SOX2_20726797_ChIP-Seq_SW620_Human0.90302139
154* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89734946
155FUS_26573619_Chip-Seq_HEK293_Human0.89322658
156TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89040413
157NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88882533
158DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88378116
159TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88108387
160RNF2_27304074_Chip-Seq_NSC_Mouse0.87734046
161EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87462125
162CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86863233
163TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86800336
164RING1B_27294783_Chip-Seq_ESCs_Mouse0.86081807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue5.82610078
2MP0005670_abnormal_white_adipose5.02721313
3MP0005503_abnormal_tendon_morphology4.79889551
4MP0003279_aneurysm4.37985361
5MP0003705_abnormal_hypodermis_morpholog4.31512410
6MP0000003_abnormal_adipose_tissue4.07493006
7MP0001958_emphysema3.83173411
8MP0005379_endocrine/exocrine_gland_phen3.74413195
9MP0009384_cardiac_valve_regurgitation3.67041813
10MP0002837_dystrophic_cardiac_calcinosis3.60889688
11MP0002909_abnormal_adrenal_gland3.51538885
12MP0002876_abnormal_thyroid_physiology3.46225944
13MP0005645_abnormal_hypothalamus_physiol3.39985183
14MP0005623_abnormal_meninges_morphology3.36186363
15MP0005375_adipose_tissue_phenotype3.36168312
16MP0004130_abnormal_muscle_cell3.34418568
17MP0005257_abnormal_intraocular_pressure3.15273352
18MP0003950_abnormal_plasma_membrane3.09250297
19MP0005666_abnormal_adipose_tissue3.02583119
20MP0006054_spinal_hemorrhage3.01012506
21MP0004185_abnormal_adipocyte_glucose2.75550857
22MP0001542_abnormal_bone_strength2.70421549
23MP0003183_abnormal_peptide_metabolism2.52466825
24MP0008438_abnormal_cutaneous_collagen2.41879126
25* MP0001881_abnormal_mammary_gland2.40338461
26MP0002638_abnormal_pupillary_reflex2.38192178
27MP0003941_abnormal_skin_development2.37808641
28MP0003091_abnormal_cell_migration2.24909027
29MP0010368_abnormal_lymphatic_system2.24706610
30MP0005023_abnormal_wound_healing2.24626009
31MP0009780_abnormal_chondrocyte_physiolo2.12932583
32MP0003959_abnormal_lean_body2.10443245
33MP0000767_abnormal_smooth_muscle2.03012352
34MP0010352_gastrointestinal_tract_polyps2.02741993
35MP0001348_abnormal_lacrimal_gland1.96864282
36MP0001501_abnormal_sleep_pattern1.82420922
37MP0005508_abnormal_skeleton_morphology1.81410865
38MP0002295_abnormal_pulmonary_circulatio1.74470757
39MP0000534_abnormal_ureter_morphology1.71885091
40MP0003195_calcinosis1.71742583
41MP0002254_reproductive_system_inflammat1.68417567
42MP0002971_abnormal_brown_adipose1.68166983
43MP0010329_abnormal_lipoprotein_level1.67060772
44MP0003787_abnormal_imprinting1.64084779
45MP0005334_abnormal_fat_pad1.60363682
46MP0009250_abnormal_appendicular_skeleto1.57593844
47MP0003122_maternal_imprinting1.57100149
48MP0001944_abnormal_pancreas_morphology1.56335149
49MP0003942_abnormal_urinary_system1.55246041
50MP0005535_abnormal_body_temperature1.54767319
51MP0010030_abnormal_orbit_morphology1.53491392
52MP0005275_abnormal_skin_tensile1.50374461
53MP0002078_abnormal_glucose_homeostasis1.49026658
54MP0006276_abnormal_autonomic_nervous1.48868067
55MP0010386_abnormal_urinary_bladder1.48478741
56MP0009115_abnormal_fat_cell1.44764454
57MP0001243_abnormal_dermal_layer1.43280477
58MP0009053_abnormal_anal_canal1.41937700
59MP0003045_fibrosis1.34932197
60MP0000678_abnormal_parathyroid_gland1.32911162
61MP0004272_abnormal_basement_membrane1.31538449
62MP0001661_extended_life_span1.27741695
63MP0005595_abnormal_vascular_smooth1.26903857
64MP0002970_abnormal_white_adipose1.25997007
65MP0005448_abnormal_energy_balance1.25336610
66MP0000751_myopathy1.15459445
67MP0005171_absent_coat_pigmentation1.14082201
68MP0003690_abnormal_glial_cell1.13939360
69MP0003953_abnormal_hormone_level1.12785370
70MP0005452_abnormal_adipose_tissue1.11293286
71MP0002693_abnormal_pancreas_physiology1.11173608
72MP0002896_abnormal_bone_mineralization1.09841864
73MP0002118_abnormal_lipid_homeostasis1.03436773
74MP0003385_abnormal_body_wall1.03239952
75MP0000733_abnormal_muscle_development1.02304453
76MP0002234_abnormal_pharynx_morphology1.00780833
77MP0001664_abnormal_digestion1.00558670
78MP0005390_skeleton_phenotype1.00068698
79MP0003724_increased_susceptibility_to0.99265965
80MP0003937_abnormal_limbs/digits/tail_de0.96589479
81MP0004043_abnormal_pH_regulation0.95893283
82MP0002115_abnormal_skeleton_extremities0.95750991
83MP0000428_abnormal_craniofacial_morphol0.94528352
84MP0004019_abnormal_vitamin_homeostasis0.94462572
85MP0000230_abnormal_systemic_arterial0.92731466
86MP0008961_abnormal_basal_metabolism0.92237139
87MP0000681_abnormal_thyroid_gland0.91538051
88MP0005197_abnormal_uvea_morphology0.91327569
89MP0000749_muscle_degeneration0.90825990
90MP0004270_analgesia0.90655190
91MP0002128_abnormal_blood_circulation0.90270615
92MP0002733_abnormal_thermal_nociception0.90076970
93MP0002282_abnormal_trachea_morphology0.89462496
94MP0004134_abnormal_chest_morphology0.88541918
95MP0000762_abnormal_tongue_morphology0.87575847
96MP0003448_altered_tumor_morphology0.86045937
97MP0004147_increased_porphyrin_level0.84867836
98MP0003879_abnormal_hair_cell0.84373629
99MP0001756_abnormal_urination0.84360311
100MP0001765_abnormal_ion_homeostasis0.83824960
101MP0001270_distended_abdomen0.83605387
102MP0002108_abnormal_muscle_morphology0.83331255
103MP0000569_abnormal_digit_pigmentation0.82940685
104MP0000432_abnormal_head_morphology0.81262721
105* MP0002572_abnormal_emotion/affect_behav0.80704818
106MP0002168_other_aberrant_phenotype0.80285303
107MP0000639_abnormal_adrenal_gland0.79242252
108MP0003191_abnormal_cellular_cholesterol0.79155581
109MP0002877_abnormal_melanocyte_morpholog0.78584179
110MP0002069_abnormal_eating/drinking_beha0.78542691
111MP0000759_abnormal_skeletal_muscle0.78330149
112MP0003755_abnormal_palate_morphology0.78017395
113MP0005164_abnormal_response_to0.77735183
114MP0003635_abnormal_synaptic_transmissio0.77513618
115MP0002734_abnormal_mechanical_nocicepti0.77098829
116MP0002060_abnormal_skin_morphology0.75987686
117MP0004858_abnormal_nervous_system0.75917542
118MP0002113_abnormal_skeleton_development0.72735547
119MP0001879_abnormal_lymphatic_vessel0.72666677
120MP0002109_abnormal_limb_morphology0.72597839
121MP0001986_abnormal_taste_sensitivity0.72342645
122MP0004215_abnormal_myocardial_fiber0.71983827
123MP0002163_abnormal_gland_morphology0.71898498
124MP0003828_pulmonary_edema0.71828974
125MP0005193_abnormal_anterior_eye0.71622480
126MP0000163_abnormal_cartilage_morphology0.70554268
127MP0009745_abnormal_behavioral_response0.69590856
128MP0006138_congestive_heart_failure0.68784094
129MP0002272_abnormal_nervous_system0.68677608
130MP0001970_abnormal_pain_threshold0.68449741
131MP0003121_genomic_imprinting0.68277501
132MP0003948_abnormal_gas_homeostasis0.68169406
133MP0001614_abnormal_blood_vessel0.66163406
134MP0001486_abnormal_startle_reflex0.65550882
135MP0001502_abnormal_circadian_rhythm0.64218659
136MP0000627_abnormal_mammary_gland0.64151258
137MP0002102_abnormal_ear_morphology0.63657014
138MP0004883_abnormal_blood_vessel0.63070409
139MP0000049_abnormal_middle_ear0.63009339
140MP0002925_abnormal_cardiovascular_devel0.62674257
141MP0004036_abnormal_muscle_relaxation0.61971513
142MP0004084_abnormal_cardiac_muscle0.61770295
143MP0002184_abnormal_innervation0.60775275
144MP0001915_intracranial_hemorrhage0.60259902
145MP0005620_abnormal_muscle_contractility0.59999547
146MP0002177_abnormal_outer_ear0.59623933
147MP0000427_abnormal_hair_cycle0.59352843
148MP0001177_atelectasis0.59322772
149MP0002063_abnormal_learning/memory/cond0.59148316
150MP0005621_abnormal_cell_physiology0.58933926
151MP0002116_abnormal_craniofacial_bone0.58782800
152MP0003795_abnormal_bone_structure0.58461012
153MP0003633_abnormal_nervous_system0.57902036
154MP0001175_abnormal_lung_morphology0.57222707
155MP0008775_abnormal_heart_ventricle0.56938469
156MP0002133_abnormal_respiratory_system0.56870067
157MP0005388_respiratory_system_phenotype0.56870067
158MP0005165_increased_susceptibility_to0.56503503
159MP0008004_abnormal_stomach_pH0.56268475
160MP0009046_muscle_twitch0.56197724
161MP0002114_abnormal_axial_skeleton0.55648389
162MP0003935_abnormal_craniofacial_develop0.55385302
163MP0002009_preneoplasia0.55224236
164MP0000462_abnormal_digestive_system0.53956673
165MP0003566_abnormal_cell_adhesion0.52813459
166MP0002064_seizures0.52569194
167MP0003115_abnormal_respiratory_system0.51979808
168MP0004133_heterotaxia0.51522588
169MP0002932_abnormal_joint_morphology0.51455974
170MP0003283_abnormal_digestive_organ0.50958453
171MP0001299_abnormal_eye_distance/0.50366480
172MP0005646_abnormal_pituitary_gland0.48675108
173MP0005187_abnormal_penis_morphology0.48473215
174MP0000538_abnormal_urinary_bladder0.47857032
175MP0001849_ear_inflammation0.46539669
176MP0003252_abnormal_bile_duct0.44949073

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.52291617
2Protrusio acetabuli (HP:0003179)6.88790815
3Oligomenorrhea (HP:0000876)6.69888418
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.64777214
5Aortic dissection (HP:0002647)5.82361666
6Aortic aneurysm (HP:0004942)5.53523152
7Insulin-resistant diabetes mellitus (HP:0000831)5.45163285
8Abnormality of calcium-phosphate metabolism (HP:0100530)5.21313211
9Soft skin (HP:0000977)4.71231153
10Hyperglycemia (HP:0003074)4.40881127
11Vascular tortuosity (HP:0004948)4.39640131
12Menstrual irregularities (HP:0000858)4.16667546
13Hypoglycemic seizures (HP:0002173)4.10464710
14Ankle contracture (HP:0006466)4.03364835
15Acanthosis nigricans (HP:0000956)4.02211566
16Atrophic scars (HP:0001075)3.92802139
17Abnormality of dentin (HP:0010299)3.88736059
18Growth hormone excess (HP:0000845)3.88364756
19Symptomatic seizures (HP:0011145)3.87736284
20Bladder diverticulum (HP:0000015)3.81444564
21Ketoacidosis (HP:0001993)3.79450972
22Hyperinsulinemic hypoglycemia (HP:0000825)3.78516312
23Arterial tortuosity (HP:0005116)3.77937497
24Genu recurvatum (HP:0002816)3.75048929
25Retinal atrophy (HP:0001105)3.67058541
26Neonatal short-limb short stature (HP:0008921)3.54955687
27Peritonitis (HP:0002586)3.54288264
28Fragile skin (HP:0001030)3.46297558
29Large for gestational age (HP:0001520)3.45809622
30Broad metatarsal (HP:0001783)3.39354217
31Dilatation of the ascending aorta (HP:0005111)3.36556994
32Spinal rigidity (HP:0003306)3.34326990
33Hyperpituitarism (HP:0010514)3.33246479
34Type 1 muscle fiber predominance (HP:0003803)3.29431013
35Wormian bones (HP:0002645)3.27929153
36Spondylolisthesis (HP:0003302)3.19560964
37Bowel diverticulosis (HP:0005222)3.17192889
38Insulin resistance (HP:0000855)3.17173307
39Pancreatic islet-cell hyperplasia (HP:0004510)3.14631034
40Follicular hyperkeratosis (HP:0007502)3.11931941
41Aortic regurgitation (HP:0001659)3.08201951
42Agitation (HP:0000713)3.06608993
43Shallow orbits (HP:0000586)3.05232650
44Blue sclerae (HP:0000592)3.03559269
45Cervical subluxation (HP:0003308)3.02148500
46Hyperthyroidism (HP:0000836)3.02130776
47Hypoglycemic coma (HP:0001325)2.99665599
48Hypertriglyceridemia (HP:0002155)2.96788114
49Hyperphosphatemia (HP:0002905)2.96141599
50Mitral valve prolapse (HP:0001634)2.92096975
51Ulnar bowing (HP:0003031)2.91768807
52Unilateral renal agenesis (HP:0000122)2.88837527
53Subcapsular cataract (HP:0000523)2.84209483
54Absent frontal sinuses (HP:0002688)2.78208453
55Abnormal eating behavior (HP:0100738)2.76090476
56Hyperparathyroidism (HP:0000843)2.75575178
57Wide anterior fontanel (HP:0000260)2.75148675
58Mesomelia (HP:0003027)2.72732334
59Abnormal delivery (HP:0001787)2.69115886
60Biconcave vertebral bodies (HP:0004586)2.68430053
61Mitral regurgitation (HP:0001653)2.67746685
62Slender build (HP:0001533)2.66821904
63Overgrowth (HP:0001548)2.66349274
64Gonadotropin excess (HP:0000837)2.61727610
65Joint laxity (HP:0001388)2.56637782
66Thyroid-stimulating hormone excess (HP:0002925)2.54421326
67Elbow flexion contracture (HP:0002987)2.52779779
68Hyperextensible skin (HP:0000974)2.51882466
69Abnormality of the acetabulum (HP:0003170)2.50401306
70Aplasia of the musculature (HP:0100854)2.47901362
71Enlarged penis (HP:0000040)2.45116475
72Hypercortisolism (HP:0001578)2.43604216
73Abnormality of the pancreatic islet cells (HP:0006476)2.42430773
74Abnormality of endocrine pancreas physiology (HP:0012093)2.42430773
75Aortic valve stenosis (HP:0001650)2.42222829
76Cardiovascular calcification (HP:0011915)2.39601369
77Turricephaly (HP:0000262)2.36726275
78Aneurysm (HP:0002617)2.36581319
79Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.36480498
80Vertebral compression fractures (HP:0002953)2.35419695
81Mitral stenosis (HP:0001718)2.35182868
82Bradycardia (HP:0001662)2.32206830
83Decreased circulating renin level (HP:0003351)2.31578468
84Accelerated skeletal maturation (HP:0005616)2.30343729
85Long foot (HP:0001833)2.28683407
86Coronal craniosynostosis (HP:0004440)2.28682294
87Nonimmune hydrops fetalis (HP:0001790)2.22995942
88Mild short stature (HP:0003502)2.21928825
89Hypoplasia of the iris (HP:0007676)2.20989232
90Abnormality of carpal bone ossification (HP:0006257)2.20709402
91Osteolytic defects of the hand bones (HP:0009699)2.19491372
92Osteolytic defects of the phalanges of the hand (HP:0009771)2.19491372
93Spinal cord lesions (HP:0100561)2.18017341
94Syringomyelia (HP:0003396)2.18017341
95Mildly elevated creatine phosphokinase (HP:0008180)2.16215877
96Pigmentary retinal degeneration (HP:0001146)2.15229401
97Complement deficiency (HP:0004431)2.13128997
98Camptodactyly of toe (HP:0001836)2.10848745
99Failure to thrive in infancy (HP:0001531)2.10532528
100Hydroxyprolinuria (HP:0003080)2.10255008
101Abnormality of proline metabolism (HP:0010907)2.10255008
102Polyphagia (HP:0002591)2.09754908
103Round ear (HP:0100830)2.09497780
104Short nail (HP:0001799)2.08484620
105Ectopia lentis (HP:0001083)2.08306445
106Hypoventilation (HP:0002791)2.08258932
107Deviation of the hallux (HP:0010051)2.07454265
108Focal motor seizures (HP:0011153)2.06621565
109Increased mean platelet volume (HP:0011877)2.06114886
110Striae distensae (HP:0001065)2.06064228
111Morphological abnormality of the middle ear (HP:0008609)2.04516597
112Renal duplication (HP:0000075)2.01984471
113Prominent supraorbital ridges (HP:0000336)2.01337655
114Epileptiform EEG discharges (HP:0011182)2.01306304
115Cerebral aneurysm (HP:0004944)2.00381725
116Abnormal ossification of hand bones (HP:0005921)1.99761185
117Neoplasm of the heart (HP:0100544)1.98885968
118EEG with generalized epileptiform discharges (HP:0011198)1.98144125
119Fibular hypoplasia (HP:0003038)1.98050455
120Upper limb amyotrophy (HP:0009129)1.97546149
121Distal upper limb amyotrophy (HP:0007149)1.97546149
122Increased variability in muscle fiber diameter (HP:0003557)1.97492112
123Abnormality of the vitreous humor (HP:0004327)1.96447428
124Hypokalemia (HP:0002900)1.95664933
125Bone cyst (HP:0012062)1.95423769
126Dysostosis multiplex (HP:0000943)1.93948314
127Epidermoid cyst (HP:0200040)1.91860071
128Bronchomalacia (HP:0002780)1.91068421
129Polar cataract (HP:0010696)1.90347678
130Hypsarrhythmia (HP:0002521)1.89882170
131Congenital glaucoma (HP:0001087)1.89483359
132Disproportionate tall stature (HP:0001519)1.89191764
133Adrenal overactivity (HP:0002717)1.88102075
134Sparse lateral eyebrow (HP:0005338)1.87965139
135Natal tooth (HP:0000695)1.87920326
136Knee flexion contracture (HP:0006380)1.87507070
137Abnormality of potassium homeostasis (HP:0011042)1.87450225
138Bowed forearm bones (HP:0003956)1.87285516
139Bowing of the arm (HP:0006488)1.87285516
140Difficulty running (HP:0009046)1.87257208
141Infantile muscular hypotonia (HP:0008947)1.86685316
142Hallux valgus (HP:0001822)1.86616161
143Broad long bones (HP:0005622)1.85848780
144Macroorchidism (HP:0000053)1.85344200
145Skin nodule (HP:0200036)1.85330795
146Ketosis (HP:0001946)1.85206582
147Pheochromocytoma (HP:0002666)1.85135753
148Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84346341
149Neonatal hypoglycemia (HP:0001998)1.84113535
150Inguinal hernia (HP:0000023)1.83969986
151Hip dysplasia (HP:0001385)1.83139282
152Late onset (HP:0003584)1.82818174
153Osteoarthritis (HP:0002758)1.82127023
154Joint stiffness (HP:0001387)1.82077090
155Reduced subcutaneous adipose tissue (HP:0003758)1.81287408
156Papilledema (HP:0001085)1.81077824
157Resting tremor (HP:0002322)1.80791261
158Hypoplasia of dental enamel (HP:0006297)1.79712487
159Buphthalmos (HP:0000557)1.79685318
160Hemiparesis (HP:0001269)1.79269549
161Hypothermia (HP:0002045)1.78677502
162Wrist flexion contracture (HP:0001239)1.77440130
163Onycholysis (HP:0001806)1.77324791
164Abnormality of the frontal sinuses (HP:0002687)1.76109290
165Mucopolysacchariduria (HP:0008155)1.75849428
166Urinary glycosaminoglycan excretion (HP:0003541)1.75849428
167Rectal prolapse (HP:0002035)1.74649958
168Right ventricular cardiomyopathy (HP:0011663)1.74592350
169Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74115206
170Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74115206
171Abnormality of polysaccharide metabolism (HP:0011012)1.74115206
172Abnormal platelet volume (HP:0011876)1.73989010
173Long toe (HP:0010511)1.73683963
174Redundant skin (HP:0001582)1.73081472
175Entropion (HP:0000621)1.71841141
176Long eyelashes (HP:0000527)1.71699540
177Increased number of teeth (HP:0011069)1.71396497
178Breech presentation (HP:0001623)1.71197283
179Abnormality of the dental pulp (HP:0006479)1.70941166
180Abnormality of the fetal cardiovascular system (HP:0010948)1.70654291
181Abnormal umbilical cord blood vessels (HP:0011403)1.70654291
182Single umbilical artery (HP:0001195)1.70654291
183Orthostatic hypotension (HP:0001278)1.70481341
184Abnormality of skull ossification (HP:0002703)1.70246552
185Large hands (HP:0001176)1.69507406
186Short clavicles (HP:0000894)1.69228635
187Postural tremor (HP:0002174)1.68603982
188Hyperkalemia (HP:0002153)1.68193394
189Tetraparesis (HP:0002273)1.66991793
190Absent eyebrow (HP:0002223)1.66637899
191Testicular neoplasm (HP:0010788)1.65968541
192Labial hypoplasia (HP:0000066)1.65783980
193Neuroendocrine neoplasm (HP:0100634)1.64050377
194Aplasia involving bones of the extremities (HP:0009825)1.63968483
195Aplasia involving bones of the upper limbs (HP:0009823)1.63968483
196Aplasia of the phalanges of the hand (HP:0009802)1.63968483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.58874855
2WNK34.92928072
3PIK3CG3.48174982
4SIK13.39109573
5INSRR3.18975559
6TTN2.89750466
7PAK22.87534005
8CAMK1D2.87158672
9PTK22.67497755
10LIMK12.34746601
11CAMK1G2.10628952
12FRK2.10129572
13PRKD32.06868216
14STK382.04365605
15CASK1.90203871
16TESK11.84552152
17ERBB41.80379025
18WNK41.80124374
19FER1.76236280
20UHMK11.73566851
21TRPM71.68341409
22SIK31.67224606
23NTRK31.61986300
24TRIB31.60938498
25LATS21.53755661
26EPHA21.44488035
27DAPK21.37932111
28MST1R1.37269184
29PAK41.37220925
30EPHB21.36052217
31TAOK31.35795120
32MAP3K31.35052065
33PAK31.31247231
34LATS11.29439328
35RIPK11.20630031
36ROCK11.19829994
37MAP3K21.19721669
38DMPK1.19113712
39MYLK1.15462791
40STK31.14753486
41MAP2K71.12589158
42EPHA31.09512174
43PRKAA21.08683914
44MELK1.07815229
45TIE11.06063503
46FGFR31.05827947
47ERN11.05644553
48FLT31.04134692
49MAP2K11.02330580
50PDK41.02061332
51PDK31.02061332
52ROCK20.99144628
53ADRBK10.98405991
54HIPK20.97019885
55MAPK130.96680378
56EPHB10.96350410
57PIK3CA0.95408050
58PRKCH0.91502413
59WNK10.90274452
60PDGFRA0.89055990
61FGFR20.88567492
62BRSK20.87662937
63BCKDK0.87562659
64ILK0.87346043
65TAOK20.87127500
66KIT0.86651693
67GRK70.84196561
68DAPK30.83862787
69BMPR1B0.83318454
70TEC0.83118151
71MAP3K10.81478251
72CAMK10.79144999
73MOS0.77837139
74RPS6KA20.77383645
75TGFBR20.76787196
76PLK20.76738765
77PAK10.75247754
78ADRBK20.74300707
79BCR0.72927329
80PNCK0.72568652
81MAP2K40.72290764
82MST40.71999162
83PASK0.70592988
84MAP3K40.70391051
85NTRK20.69570047
86LMTK20.69009550
87PDK20.67651224
88ICK0.67001102
89PRKCE0.66953037
90PRKD20.65606013
91MTOR0.65590023
92MAP3K120.64983908
93MAP3K130.63727072
94RET0.63578870
95STK160.63452240
96AKT30.61971117
97MAP2K30.61404177
98CDC42BPA0.60982883
99KSR20.60754226
100MARK20.60481884
101STK100.60238806
102SGK2230.59842662
103SGK4940.59842662
104PRKAA10.59637451
105MAPK70.59115523
106JAK20.58238473
107CAMKK20.57048827
108ABL20.54786382
109IGF1R0.54649099
110PKN20.53674744
111SIK20.53574212
112SGK20.52413826
113PTK2B0.51585919
114DAPK10.51474881
115CDK120.51078042
116JAK10.50571198
117MAP3K60.50525073
118MAPKAPK30.50165236
119BMX0.49405858
120PRKG20.48827505
121CAMK2G0.48204866
122PAK60.47450845
123ERBB30.47352605
124NEK10.46796537
125TNIK0.46147427
126CDK50.45774958
127FGFR40.44513176
128PIM20.44206552
129GSK3A0.44045667
130NTRK10.43477061
131PRKACG0.41868548
132SGK10.41589016
133PRKD10.40242783
134MINK10.39602476
135STK38L0.38592770
136DYRK1B0.37278479
137CDK80.37025025
138DDR20.36989249
139FGFR10.36759769
140PDGFRB0.35963578
141SGK30.35583130
142GRK50.35234979
143NEK90.35008883
144KSR10.34714853
145MET0.34279918
146ABL10.33308677
147CDK90.33235992
148MAPKAPK20.33222226
149PRKACA0.32362038
150NEK60.32004147
151NEK20.31410931
152MAP3K140.31398825
153SMG10.30540220
154CHEK20.28647237
155INSR0.28438356
156SRC0.25475728
157STK240.23642218
158AURKB0.22488904
159CHUK0.22046773
160EIF2AK30.19022857
161RPS6KL10.18881735
162RPS6KC10.18881735

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.88959608
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.13307933
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.02689206
4Fatty acid biosynthesis_Homo sapiens_hsa000612.98118861
5Proteoglycans in cancer_Homo sapiens_hsa052052.38825975
6PPAR signaling pathway_Homo sapiens_hsa033202.26827146
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.23820913
8Insulin secretion_Homo sapiens_hsa049112.21843750
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.17741471
10Regulation of actin cytoskeleton_Homo sapiens_hsa048102.14707508
11Adherens junction_Homo sapiens_hsa045202.14054654
12Amoebiasis_Homo sapiens_hsa051462.10087662
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.07528685
14Hippo signaling pathway_Homo sapiens_hsa043901.99656827
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98500046
16Type II diabetes mellitus_Homo sapiens_hsa049301.94843892
17Renin secretion_Homo sapiens_hsa049241.82011503
18Small cell lung cancer_Homo sapiens_hsa052221.81551515
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.79418508
20Glycerolipid metabolism_Homo sapiens_hsa005611.70914660
21Type I diabetes mellitus_Homo sapiens_hsa049401.61966977
22TGF-beta signaling pathway_Homo sapiens_hsa043501.58689399
23Basal cell carcinoma_Homo sapiens_hsa052171.58471000
24Hedgehog signaling pathway_Homo sapiens_hsa043401.57823971
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56717248
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.53492033
27Caffeine metabolism_Homo sapiens_hsa002321.47611464
28Bladder cancer_Homo sapiens_hsa052191.47447814
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46834910
30Propanoate metabolism_Homo sapiens_hsa006401.46566268
31GABAergic synapse_Homo sapiens_hsa047271.45283141
32Fatty acid metabolism_Homo sapiens_hsa012121.45013274
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.44046624
34MicroRNAs in cancer_Homo sapiens_hsa052061.43663421
35Ovarian steroidogenesis_Homo sapiens_hsa049131.42093345
36Circadian entrainment_Homo sapiens_hsa047131.39840574
37Vibrio cholerae infection_Homo sapiens_hsa051101.39042604
38Synaptic vesicle cycle_Homo sapiens_hsa047211.38606558
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34363373
40Morphine addiction_Homo sapiens_hsa050321.33900813
41Platelet activation_Homo sapiens_hsa046111.33480994
42p53 signaling pathway_Homo sapiens_hsa041151.32371274
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32238776
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.22100619
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21163869
46Pathways in cancer_Homo sapiens_hsa052001.20667566
47Salivary secretion_Homo sapiens_hsa049701.20626456
48AMPK signaling pathway_Homo sapiens_hsa041521.19826392
49Nicotine addiction_Homo sapiens_hsa050331.19524765
50Collecting duct acid secretion_Homo sapiens_hsa049661.17803680
51Malaria_Homo sapiens_hsa051441.15988581
52Taste transduction_Homo sapiens_hsa047421.15677892
53Glucagon signaling pathway_Homo sapiens_hsa049221.15193946
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.13012841
55Protein digestion and absorption_Homo sapiens_hsa049741.12776174
56Rap1 signaling pathway_Homo sapiens_hsa040151.09994549
57Cocaine addiction_Homo sapiens_hsa050301.09287522
58Prostate cancer_Homo sapiens_hsa052151.09266285
59Shigellosis_Homo sapiens_hsa051311.08733482
60Circadian rhythm_Homo sapiens_hsa047101.08473862
61Vascular smooth muscle contraction_Homo sapiens_hsa042701.05991717
62* cAMP signaling pathway_Homo sapiens_hsa040241.03211086
63Tight junction_Homo sapiens_hsa045301.03179004
64Protein export_Homo sapiens_hsa030601.02160531
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00818473
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00660270
67Amphetamine addiction_Homo sapiens_hsa050310.99991955
68Lysosome_Homo sapiens_hsa041420.99017210
69* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98955150
70Chronic myeloid leukemia_Homo sapiens_hsa052200.98397725
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97617005
72Serotonergic synapse_Homo sapiens_hsa047260.95825293
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94621630
74TNF signaling pathway_Homo sapiens_hsa046680.93798029
75Dorso-ventral axis formation_Homo sapiens_hsa043200.91886296
76Dopaminergic synapse_Homo sapiens_hsa047280.91879712
77Pancreatic cancer_Homo sapiens_hsa052120.91742382
78Fat digestion and absorption_Homo sapiens_hsa049750.90865407
79Insulin signaling pathway_Homo sapiens_hsa049100.89683280
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89561767
81Glutamatergic synapse_Homo sapiens_hsa047240.89400992
82Cholinergic synapse_Homo sapiens_hsa047250.88624881
83Gastric acid secretion_Homo sapiens_hsa049710.88242194
84Endocytosis_Homo sapiens_hsa041440.87825403
85Long-term depression_Homo sapiens_hsa047300.87207585
86Insulin resistance_Homo sapiens_hsa049310.86084815
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86080338
88Thyroid hormone synthesis_Homo sapiens_hsa049180.85708855
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.84243081
90Glioma_Homo sapiens_hsa052140.82207734
91beta-Alanine metabolism_Homo sapiens_hsa004100.81158276
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.80747144
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80151483
94Long-term potentiation_Homo sapiens_hsa047200.79385562
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.79356898
96* Calcium signaling pathway_Homo sapiens_hsa040200.77393262
97Olfactory transduction_Homo sapiens_hsa047400.76861070
98Sphingolipid metabolism_Homo sapiens_hsa006000.75735604
99Prolactin signaling pathway_Homo sapiens_hsa049170.75729492
100Estrogen signaling pathway_Homo sapiens_hsa049150.75221637
101ECM-receptor interaction_Homo sapiens_hsa045120.73889808
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71429631
103Hepatitis B_Homo sapiens_hsa051610.71059986
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69349115
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68585393
106Pyruvate metabolism_Homo sapiens_hsa006200.68461292
107Sulfur metabolism_Homo sapiens_hsa009200.67728729
108Rheumatoid arthritis_Homo sapiens_hsa053230.67689563
109MAPK signaling pathway_Homo sapiens_hsa040100.67598084
110Melanogenesis_Homo sapiens_hsa049160.67049488
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.66160039
112* Oxytocin signaling pathway_Homo sapiens_hsa049210.63860701
113HTLV-I infection_Homo sapiens_hsa051660.62691086
114Phenylalanine metabolism_Homo sapiens_hsa003600.62669071
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59644282
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59522174
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59177415
118N-Glycan biosynthesis_Homo sapiens_hsa005100.58866863
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58366782
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56763636
121Pancreatic secretion_Homo sapiens_hsa049720.56235374
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55832467
123Colorectal cancer_Homo sapiens_hsa052100.55657979
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54914657
125Viral myocarditis_Homo sapiens_hsa054160.54659492
126Fatty acid degradation_Homo sapiens_hsa000710.54505704
127Salmonella infection_Homo sapiens_hsa051320.54251387
128Autoimmune thyroid disease_Homo sapiens_hsa053200.52956766
129Dilated cardiomyopathy_Homo sapiens_hsa054140.52745926
130Endometrial cancer_Homo sapiens_hsa052130.51094545
131Toxoplasmosis_Homo sapiens_hsa051450.49966958
132Phagosome_Homo sapiens_hsa041450.49923534
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49331442
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.49168897
135Prion diseases_Homo sapiens_hsa050200.48440051
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47849542
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45865441
138Ras signaling pathway_Homo sapiens_hsa040140.45639543
139Focal adhesion_Homo sapiens_hsa045100.45194347
140Viral carcinogenesis_Homo sapiens_hsa052030.44733449
141Butanoate metabolism_Homo sapiens_hsa006500.43851054
142Gap junction_Homo sapiens_hsa045400.42293191
143Renal cell carcinoma_Homo sapiens_hsa052110.42251024
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41423842
145Melanoma_Homo sapiens_hsa052180.41293740
146ErbB signaling pathway_Homo sapiens_hsa040120.41094352
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40896865
148Apoptosis_Homo sapiens_hsa042100.40640472
149Tyrosine metabolism_Homo sapiens_hsa003500.39927255
150Thyroid cancer_Homo sapiens_hsa052160.39827849
151Arachidonic acid metabolism_Homo sapiens_hsa005900.39806168
152Inositol phosphate metabolism_Homo sapiens_hsa005620.38757505
153FoxO signaling pathway_Homo sapiens_hsa040680.38662971
154Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37628538
155GnRH signaling pathway_Homo sapiens_hsa049120.37338365
156Linoleic acid metabolism_Homo sapiens_hsa005910.37176422
157Hepatitis C_Homo sapiens_hsa051600.36127276
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36089134
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.35646272
160Selenocompound metabolism_Homo sapiens_hsa004500.35023482
161Axon guidance_Homo sapiens_hsa043600.34605617
162ABC transporters_Homo sapiens_hsa020100.33916596
163Wnt signaling pathway_Homo sapiens_hsa043100.33574518

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