P2RX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)9.31794550
2digestion (GO:0007586)8.27231875
3protein retention in ER lumen (GO:0006621)8.10100699
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.54697985
5neutrophil activation involved in immune response (GO:0002283)6.09277667
6valine metabolic process (GO:0006573)5.77646331
7ribosomal small subunit assembly (GO:0000028)5.68428911
8cobalamin metabolic process (GO:0009235)5.30130183
9cholesterol catabolic process (GO:0006707)4.84848020
10sterol catabolic process (GO:0016127)4.84848020
11positive regulation of B cell differentiation (GO:0045579)4.83833523
12response to peptidoglycan (GO:0032494)4.82950608
13galactose catabolic process (GO:0019388)4.75621263
14transcytosis (GO:0045056)4.63700289
15definitive hemopoiesis (GO:0060216)4.62638024
16cellular extravasation (GO:0045123)4.62110878
17peptidyl-proline hydroxylation (GO:0019511)4.60853981
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.58241263
19regulation of mast cell degranulation (GO:0043304)4.55995862
20protein targeting to ER (GO:0045047)4.47459530
21cotranslational protein targeting to membrane (GO:0006613)4.46436758
22viral transcription (GO:0019083)4.42706487
23leukotriene biosynthetic process (GO:0019370)4.42587766
24mitochondrial calcium ion transport (GO:0006851)4.37582161
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.33690928
26positive regulation by organism of defense response of other organism involved in symbiotic interact4.33690928
27modulation by symbiont of host immune response (GO:0052553)4.33690928
28positive regulation by symbiont of host defense response (GO:0052509)4.33690928
29modulation by symbiont of host defense response (GO:0052031)4.33690928
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.33690928
31translational termination (GO:0006415)4.31072902
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.30022519
33regulation of mast cell activation involved in immune response (GO:0033006)4.29943071
34establishment of protein localization to endoplasmic reticulum (GO:0072599)4.26370929
35protein localization to endoplasmic reticulum (GO:0070972)4.24925147
36positive regulation of mast cell activation (GO:0033005)4.24769447
37neutrophil activation (GO:0042119)4.24181111
38detection of other organism (GO:0098543)4.19019222
39proline biosynthetic process (GO:0006561)4.17261007
40immunoglobulin mediated immune response (GO:0016064)4.16339477
41detection of bacterium (GO:0016045)4.14564342
42regulation of myeloid leukocyte mediated immunity (GO:0002886)4.09626263
43regulation of B cell receptor signaling pathway (GO:0050855)4.06607913
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.98922916
45negative regulation of cell killing (GO:0031342)3.98922916
46positive regulation of mast cell degranulation (GO:0043306)3.97320229
47positive regulation of mast cell activation involved in immune response (GO:0033008)3.97320229
48regulation of mast cell activation (GO:0033003)3.92593884
49branched-chain amino acid catabolic process (GO:0009083)3.92178536
50regulation of leukocyte degranulation (GO:0043300)3.90480459
51microglial cell activation (GO:0001774)3.89344029
52COPI coating of Golgi vesicle (GO:0048205)3.87622675
53Golgi transport vesicle coating (GO:0048200)3.87622675
54antigen processing and presentation via MHC class Ib (GO:0002475)3.87145384
55thrombin receptor signaling pathway (GO:0070493)3.86048319
56translational elongation (GO:0006414)3.85613640
57positive regulation of heat generation (GO:0031652)3.85432567
58branched-chain amino acid metabolic process (GO:0009081)3.84593972
59glycolipid catabolic process (GO:0019377)3.82819609
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80273587
61regulation of B cell differentiation (GO:0045577)3.79123996
62granulocyte activation (GO:0036230)3.78247871
63regulation of fever generation (GO:0031620)3.74965468
64leukocyte migration involved in inflammatory response (GO:0002523)3.71781768
65neutrophil mediated immunity (GO:0002446)3.68554564
66B cell receptor signaling pathway (GO:0050853)3.68100929
67positive regulation of granulocyte differentiation (GO:0030854)3.66757445
68megakaryocyte development (GO:0035855)3.66576601
69response to muramyl dipeptide (GO:0032495)3.66446985
70membrane lipid catabolic process (GO:0046466)3.63335454
71signal peptide processing (GO:0006465)3.60315193
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57166281
73antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57166281
74regulation of phospholipase A2 activity (GO:0032429)3.55553617
75protein hydroxylation (GO:0018126)3.54104185
76myeloid cell activation involved in immune response (GO:0002275)3.53970123
77intestinal absorption (GO:0050892)3.53944949
78B cell mediated immunity (GO:0019724)3.53743898
79leukocyte aggregation (GO:0070486)3.47126129
80protein maturation by protein folding (GO:0022417)3.46156484
81leukocyte degranulation (GO:0043299)3.44085519
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.43104098
83response to host immune response (GO:0052572)3.43104098
84cysteine metabolic process (GO:0006534)3.42993884
85macrophage activation involved in immune response (GO:0002281)3.40645722
86defense response to protozoan (GO:0042832)3.39986703
87regulation of platelet aggregation (GO:0090330)3.35512070
88negative regulation of erythrocyte differentiation (GO:0045647)3.34509550
89positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.31841025
90negative regulation of interleukin-12 production (GO:0032695)3.30489800
91GDP-mannose metabolic process (GO:0019673)3.30477551
92ribosomal small subunit biogenesis (GO:0042274)3.29644144
93regulation of gamma-delta T cell differentiation (GO:0045586)3.26344349
94detection of external biotic stimulus (GO:0098581)3.25902536
95response to protozoan (GO:0001562)3.25902210
96negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.25444070
97positive regulation of nuclease activity (GO:0032075)3.23967802
98activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.23058300
99positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.22882226
100regulation of regulated secretory pathway (GO:1903305)3.22799706
101viral life cycle (GO:0019058)3.22473113
102nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21093316
103translational initiation (GO:0006413)3.18336469
104DNA deamination (GO:0045006)3.16809608
105hypotonic response (GO:0006971)3.14523807
106leukotriene metabolic process (GO:0006691)3.14036976
107response to interferon-beta (GO:0035456)3.13953432
108negative regulation of phagocytosis (GO:0050765)3.13534990
109toxin transport (GO:1901998)3.13006840
110negative regulation of lymphocyte mediated immunity (GO:0002707)3.12539286
111serine family amino acid biosynthetic process (GO:0009070)3.12392631
112cellular protein complex disassembly (GO:0043624)3.10942589
113pentose-phosphate shunt (GO:0006098)3.10664623
114macrophage activation (GO:0042116)3.10624777
115Arp2/3 complex-mediated actin nucleation (GO:0034314)3.10574321
116regulation of erythrocyte differentiation (GO:0045646)3.10225870
117respiratory burst (GO:0045730)3.08358675
118response to host (GO:0075136)3.08090163
119response to host defenses (GO:0052200)3.08090163
120response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.08090163
121germinal center formation (GO:0002467)3.08059707
122positive regulation of gamma-delta T cell activation (GO:0046645)3.07785996
123ceramide catabolic process (GO:0046514)3.06891401
124formation of translation preinitiation complex (GO:0001731)3.05166520
125negative regulation of digestive system process (GO:0060457)3.04541468
126protein targeting to membrane (GO:0006612)3.02189804
127endoplasmic reticulum unfolded protein response (GO:0030968)3.01616653
128regulation of nuclease activity (GO:0032069)2.93775139
129negative regulation of leukocyte mediated immunity (GO:0002704)2.93214689
130detection of biotic stimulus (GO:0009595)2.93160093
131regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92563725
132response to endoplasmic reticulum stress (GO:0034976)2.89383074
133cellular response to unfolded protein (GO:0034620)2.88883787
134negative regulation of T-helper cell differentiation (GO:0045623)2.88399630
135negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.88399630
136regulation of MHC class II biosynthetic process (GO:0045346)2.88265196
137regulation of antigen processing and presentation (GO:0002577)2.87855672
138L-serine metabolic process (GO:0006563)2.85328081
139mature B cell differentiation involved in immune response (GO:0002313)2.85268521
140regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.84961121
141regulation of granulocyte differentiation (GO:0030852)2.84420023
142regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84004076
143myeloid leukocyte mediated immunity (GO:0002444)2.83927754
144negative regulation of T cell mediated immunity (GO:0002710)2.83763210
145positive regulation of leukocyte degranulation (GO:0043302)2.82995134
146positive regulation of antigen processing and presentation (GO:0002579)2.82010765
147positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81861339
148positive thymic T cell selection (GO:0045059)2.81096961
149mast cell activation (GO:0045576)2.80305387
150regulation of heat generation (GO:0031650)2.80049768
151cellular response to topologically incorrect protein (GO:0035967)2.78843857
152antigen processing and presentation of endogenous antigen (GO:0019883)2.78799351
153regulation of B cell apoptotic process (GO:0002902)2.77753337
154protein complex disassembly (GO:0043241)2.77424266
155regulation of interferon-beta biosynthetic process (GO:0045357)2.76944211
156deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76772585
157positive regulation of regulated secretory pathway (GO:1903307)2.76376652
158one-carbon compound transport (GO:0019755)2.75818543
159maintenance of protein localization in organelle (GO:0072595)2.74821846
160regulation of gamma-delta T cell activation (GO:0046643)2.74006333
161positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.73718895
162negative thymic T cell selection (GO:0045060)2.72700372
163protein N-linked glycosylation via asparagine (GO:0018279)2.72234499
164negative regulation of epidermal cell differentiation (GO:0045605)2.72067575
165regulation of platelet activation (GO:0010543)2.71948032
166glutamine metabolic process (GO:0006541)2.69428764
167ER-nucleus signaling pathway (GO:0006984)2.68984614
168Peyers patch development (GO:0048541)2.68551853
169mucosal-associated lymphoid tissue development (GO:0048537)2.68551853
170peptidyl-asparagine modification (GO:0018196)2.68430754
171negative regulation of interleukin-6 production (GO:0032715)2.68387109
172pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.67890903
173NADPH regeneration (GO:0006740)2.67699929
174fucose catabolic process (GO:0019317)2.67533314
175L-fucose metabolic process (GO:0042354)2.67533314
176L-fucose catabolic process (GO:0042355)2.67533314
177cellular modified amino acid catabolic process (GO:0042219)2.67170102
178proline metabolic process (GO:0006560)2.66912270
179peptide catabolic process (GO:0043171)2.65883915
180G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.64715885
181endosome to melanosome transport (GO:0035646)2.63622243
182endosome to pigment granule transport (GO:0043485)2.63622243
183hexose catabolic process (GO:0019320)2.62876026
184creatine metabolic process (GO:0006600)2.60722986
185platelet aggregation (GO:0070527)2.59056725
186retinoic acid receptor signaling pathway (GO:0048384)2.58922805
187translation (GO:0006412)2.57011086
188exocrine pancreas development (GO:0031017)11.6519693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.79575335
2SCL_19346495_ChIP-Seq_HPC-7_Human3.57047529
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.47435251
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15217266
5* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.89664040
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78475391
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.58723027
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.51105997
9MYC_22102868_ChIP-Seq_BL_Human2.51101137
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44855186
11* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.42839049
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.37850439
13GATA1_22025678_ChIP-Seq_K562_Human2.25269563
14* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.15106359
15SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.14766610
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14244798
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12764853
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11012145
19GATA1_19941826_ChIP-Seq_K562_Human2.09471090
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08333987
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01130839
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97779272
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96901237
24VDR_21846776_ChIP-Seq_THP-1_Human1.96848968
25GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.96028483
26ERG_20887958_ChIP-Seq_HPC-7_Mouse1.95527186
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95358749
28SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.89185682
29* SPI1_23547873_ChIP-Seq_NB4_Human1.85790745
30* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.83987475
31* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.81808184
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81234970
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80693403
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.77540418
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73802665
36* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.73575667
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.72249475
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71506117
39* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69499332
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67484991
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65538221
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63195967
43MYB_26560356_Chip-Seq_TH2_Human1.63157414
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60229717
45GATA3_27048872_Chip-Seq_THYMUS_Human1.59923168
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59351080
47* RUNX1_22412390_ChIP-Seq_EML_Mouse1.55240791
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54339190
49VDR_24787735_ChIP-Seq_THP-1_Human1.52576203
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51770223
51GATA2_19941826_ChIP-Seq_K562_Human1.49444101
52* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49186887
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.47040026
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.46435741
55VDR_24763502_ChIP-Seq_THP-1_Human1.45537062
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44542360
57TCF7_22412390_ChIP-Seq_EML_Mouse1.43688801
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42947156
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42203221
60* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.41368649
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40507076
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39174587
63KDM2B_26808549_Chip-Seq_DND41_Human1.37265529
64CIITA_25753668_ChIP-Seq_RAJI_Human1.37215180
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35569395
66* UTX_26944678_Chip-Seq_JUKART_Human1.34816863
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34654093
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33625013
69MAF_26560356_Chip-Seq_TH1_Human1.33193654
70* NCOR1_26117541_ChIP-Seq_K562_Human1.32265171
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31990704
72* BCL6_27268052_Chip-Seq_Bcells_Human1.30883895
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.28517154
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.28312972
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.28182450
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28047091
77MYB_26560356_Chip-Seq_TH1_Human1.27261008
78* GATA1_19941827_ChIP-Seq_MEL_Mouse1.26767173
79GATA3_26560356_Chip-Seq_TH2_Human1.26337163
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26043725
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24603912
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24590405
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.23864739
84JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19378742
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19050808
86RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18466400
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18275919
88RUNX_20019798_ChIP-Seq_JUKART_Human1.18094543
89XRN2_22483619_ChIP-Seq_HELA_Human1.17956107
90FOXP3_21729870_ChIP-Seq_TREG_Human1.17673006
91* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.16900349
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16500208
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15950601
94SPI1_20517297_ChIP-Seq_HL60_Human1.15427046
95GABP_17652178_ChIP-ChIP_JURKAT_Human1.14945795
96* BCOR_27268052_Chip-Seq_Bcells_Human1.14035749
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13866242
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12781745
99EST1_17652178_ChIP-ChIP_JURKAT_Human1.12284248
100IRF8_27001747_Chip-Seq_BMDM_Mouse1.12205960
101LXR_22292898_ChIP-Seq_THP-1_Human1.12187178
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11966211
103E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11887691
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11800241
105GABP_19822575_ChIP-Seq_HepG2_Human1.11572720
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11263019
107PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10811854
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10095386
109PU_27001747_Chip-Seq_BMDM_Mouse1.09894565
110* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08829368
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08764166
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08642746
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08161917
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07928969
115VDR_23849224_ChIP-Seq_CD4+_Human1.06893971
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05167857
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04035892
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03456828
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02196044
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01918547
121CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00319445
122SRF_21415370_ChIP-Seq_HL-1_Mouse0.99479395
123PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99408602
124* P300_27268052_Chip-Seq_Bcells_Human0.98538661
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98418870
126PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98045506
127CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97997529
128MAF_26560356_Chip-Seq_TH2_Human0.97719356
129* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.97686760
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96554136
131DCP1A_22483619_ChIP-Seq_HELA_Human0.96341707
132CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95683506
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95370912
134KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93489846
135FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92952375
136SPI1_23127762_ChIP-Seq_K562_Human0.92767640
137KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92264418
138GATA4_25053715_ChIP-Seq_YYC3_Human0.91368444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract6.29797915
2MP0001666_abnormal_nutrient_absorption5.98091324
3MP0005220_abnormal_exocrine_pancreas4.88739133
4MP0005365_abnormal_bile_salt4.12258428
5MP0003868_abnormal_feces_composition3.14474752
6MP0010386_abnormal_urinary_bladder3.07499262
7MP0005084_abnormal_gallbladder_morpholo3.05342170
8MP0006054_spinal_hemorrhage2.83645272
9MP0001664_abnormal_digestion2.83567845
10MP0004147_increased_porphyrin_level2.80865904
11MP0002396_abnormal_hematopoietic_system2.49824110
12MP0004808_abnormal_hematopoietic_stem2.22467371
13MP0003172_abnormal_lysosome_physiology2.19206200
14MP0005367_renal/urinary_system_phenotyp2.11191724
15MP0000516_abnormal_urinary_system2.11191724
16MP0000490_abnormal_crypts_of2.08119934
17MP0002132_abnormal_respiratory_system1.98664465
18MP0001873_stomach_inflammation1.94950007
19MP0005464_abnormal_platelet_physiology1.92238077
20MP0000465_gastrointestinal_hemorrhage1.90863958
21MP0005085_abnormal_gallbladder_physiolo1.86894848
22MP0003300_gastrointestinal_ulcer1.76620713
23MP0003959_abnormal_lean_body1.76582987
24MP0006082_CNS_inflammation1.64966562
25MP0003638_abnormal_response/metabolism_1.63237069
26MP0009278_abnormal_bone_marrow1.62833496
27MP0003828_pulmonary_edema1.61635300
28MP0002693_abnormal_pancreas_physiology1.57955198
29MP0003763_abnormal_thymus_physiology1.56369455
30MP0010155_abnormal_intestine_physiology1.56124255
31MP0003436_decreased_susceptibility_to1.50372772
32MP0004947_skin_inflammation1.50085532
33MP0008004_abnormal_stomach_pH1.49059917
34MP0009764_decreased_sensitivity_to1.48214348
35MP0005397_hematopoietic_system_phenotyp1.45681992
36MP0001545_abnormal_hematopoietic_system1.45681992
37MP0000685_abnormal_immune_system1.45260666
38MP0004264_abnormal_extraembryonic_tissu1.42357065
39MP0001851_eye_inflammation1.35890654
40MP0003806_abnormal_nucleotide_metabolis1.31452531
41MP0001663_abnormal_digestive_system1.30137206
42MP0001845_abnormal_inflammatory_respons1.28995776
43MP0008260_abnormal_autophagy1.28294112
44MP0001756_abnormal_urination1.28092658
45MP0009333_abnormal_splenocyte_physiolog1.25876621
46MP0009785_altered_susceptibility_to1.25783138
47MP0003183_abnormal_peptide_metabolism1.23996924
48MP0002166_altered_tumor_susceptibility1.20969003
49MP0003075_altered_response_to1.20121882
50MP0003303_peritoneal_inflammation1.18962810
51MP0005451_abnormal_body_composition1.17402978
52MP0002398_abnormal_bone_marrow1.16625354
53MP0005671_abnormal_response_to1.15453695
54MP0003866_abnormal_defecation1.15387807
55MP0001835_abnormal_antigen_presentation1.15156043
56MP0005025_abnormal_response_to1.14311548
57MP0000689_abnormal_spleen_morphology1.12914575
58MP0003656_abnormal_erythrocyte_physiolo1.10732390
59MP0002420_abnormal_adaptive_immunity1.08347698
60MP0005381_digestive/alimentary_phenotyp1.08151118
61MP0002419_abnormal_innate_immunity1.06575983
62MP0001944_abnormal_pancreas_morphology1.04392877
63MP0001819_abnormal_immune_cell1.02688081
64MP0001764_abnormal_homeostasis1.02422537
65MP0009643_abnormal_urine_homeostasis1.02026110
66MP0005174_abnormal_tail_pigmentation1.01583508
67MP0002722_abnormal_immune_system1.01552218
68MP0005165_increased_susceptibility_to1.00501369
69MP0001800_abnormal_humoral_immune0.98841306
70MP0002405_respiratory_system_inflammati0.98000705
71MP0002998_abnormal_bone_remodeling0.97804709
72MP0000470_abnormal_stomach_morphology0.94435523
73MP0008469_abnormal_protein_level0.94405332
74MP0002723_abnormal_immune_serum0.94175790
75MP0003705_abnormal_hypodermis_morpholog0.93403401
76MP0002452_abnormal_antigen_presenting0.92949411
77MP0005448_abnormal_energy_balance0.92286579
78MP0002429_abnormal_blood_cell0.90843891
79MP0003191_abnormal_cellular_cholesterol0.89541636
80MP0000716_abnormal_immune_system0.88587480
81MP0001986_abnormal_taste_sensitivity0.87805133
82MP0000015_abnormal_ear_pigmentation0.87243019
83MP0009765_abnormal_xenobiotic_induced0.86977996
84MP0002095_abnormal_skin_pigmentation0.86169582
85MP0005058_abnormal_lysosome_morphology0.85374774
86MP0008438_abnormal_cutaneous_collagen0.84718774
87MP0010352_gastrointestinal_tract_polyps0.84514345
88MP0005000_abnormal_immune_tolerance0.83131601
89MP0005166_decreased_susceptibility_to0.83029654
90MP0002019_abnormal_tumor_incidence0.82446909
91MP0002148_abnormal_hypersensitivity_rea0.82223138
92MP0000703_abnormal_thymus_morphology0.82126574
93MP0004883_abnormal_blood_vessel0.81999956
94MP0003186_abnormal_redox_activity0.81681918
95MP0003943_abnormal_hepatobiliary_system0.81677583
96MP0005332_abnormal_amino_acid0.81534618
97MP0002118_abnormal_lipid_homeostasis0.80032123
98MP0005390_skeleton_phenotype0.79658031
99MP0005310_abnormal_salivary_gland0.79497564
100MP0000249_abnormal_blood_vessel0.78029419
101MP0003693_abnormal_embryo_hatching0.77586911
102MP0004510_myositis0.77134756
103MP0000598_abnormal_liver_morphology0.76683098
104MP0000858_altered_metastatic_potential0.75748588
105MP0005164_abnormal_response_to0.75511148
106MP0000343_altered_response_to0.73965294
107MP0005075_abnormal_melanosome_morpholog0.73374203
108MP0000534_abnormal_ureter_morphology0.72473137
109MP0005319_abnormal_enzyme/_coenzyme0.71620347
110MP0006036_abnormal_mitochondrial_physio0.71287890
111MP0002009_preneoplasia0.70547493
112MP0000750_abnormal_muscle_regeneration0.70078206
113MP0001533_abnormal_skeleton_physiology0.69044426
114MP0003279_aneurysm0.68811687
115MP0002006_tumorigenesis0.68645657
116MP0002135_abnormal_kidney_morphology0.68593227
117MP0005535_abnormal_body_temperature0.68403119
118MP0008874_decreased_physiological_sensi0.64173961
119MP0008961_abnormal_basal_metabolism0.64077049
120MP0009763_increased_sensitivity_to0.64019145
121MP0001853_heart_inflammation0.63992494
122MP0002089_abnormal_postnatal_growth/wei0.62414189
123MP0001790_abnormal_immune_system0.61854940
124MP0005387_immune_system_phenotype0.61854940
125MP0002277_abnormal_respiratory_mucosa0.61782489
126MP0000477_abnormal_intestine_morphology0.61494235
127MP0003795_abnormal_bone_structure0.61367880
128MP0005167_abnormal_blood-brain_barrier0.59647710
129MP0002138_abnormal_hepatobiliary_system0.58008251
130MP0003724_increased_susceptibility_to0.57901454
131MP0009642_abnormal_blood_homeostasis0.55383651
132MP0004381_abnormal_hair_follicle0.53529755
133MP0003448_altered_tumor_morphology0.52630120
134MP0008873_increased_physiological_sensi0.50763926
135MP0000681_abnormal_thyroid_gland0.50732546
136MP0005410_abnormal_fertilization0.48863179

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)7.50458796
2Aortic aneurysm (HP:0004942)6.49208252
3Facial diplegia (HP:0001349)4.79324059
4Aortic dissection (HP:0002647)4.77604073
5Increased density of long bones (HP:0006392)4.73855591
6Stomatitis (HP:0010280)4.66847454
7Thrombocytosis (HP:0001894)4.45073981
8Steatorrhea (HP:0002570)4.39814115
9Obstructive lung disease (HP:0006536)4.36906358
10Chronic obstructive pulmonary disease (HP:0006510)4.36906358
11Short chin (HP:0000331)4.29172467
12Abnormality of macrophages (HP:0004311)4.26688114
13Recurrent fungal infections (HP:0002841)3.99839907
14Panhypogammaglobulinemia (HP:0003139)3.89648465
15Hypoproteinemia (HP:0003075)3.84064975
16Meningitis (HP:0001287)3.69803071
17Petechiae (HP:0000967)3.64991487
18Encephalitis (HP:0002383)3.54822893
19Recurrent cutaneous fungal infections (HP:0011370)3.52908362
20Chronic mucocutaneous candidiasis (HP:0002728)3.52908362
21Fatigue (HP:0012378)3.47816101
22Orchitis (HP:0100796)3.44317155
23Recurrent skin infections (HP:0001581)3.37352648
24Abnormality of subcutaneous fat tissue (HP:0001001)3.37054561
25Mediastinal lymphadenopathy (HP:0100721)3.34027587
26Joint stiffness (HP:0001387)3.25477687
27Recurrent gram-negative bacterial infections (HP:0005420)3.22276882
28Agammaglobulinemia (HP:0004432)3.22204854
29Fat malabsorption (HP:0002630)3.20238897
30Aortic regurgitation (HP:0001659)3.17703130
31Abnormality of cells of the erythroid lineage (HP:0012130)3.16149837
32Optic neuritis (HP:0100653)3.14613570
33Retrobulbar optic neuritis (HP:0100654)3.14613570
34Increased IgE level (HP:0003212)3.13516156
35Granulocytopenia (HP:0001913)3.09643147
36Cellulitis (HP:0100658)3.07569912
37IgM deficiency (HP:0002850)3.07333078
38Decreased subcutaneous fat (HP:0001002)3.02569448
39Gastrointestinal dysmotility (HP:0002579)2.95872188
40Hypoplasia of the pons (HP:0012110)2.95634741
41Episodic fever (HP:0001954)2.95154873
42Hepatosplenomegaly (HP:0001433)2.94192704
43Abnormal number of erythroid precursors (HP:0012131)2.93841041
44Urticaria (HP:0001025)2.92266113
45Vasculitis (HP:0002633)2.89194287
46Aplastic anemia (HP:0001915)2.88765039
47Leukocytosis (HP:0001974)2.88073475
48Vacuolated lymphocytes (HP:0001922)2.85151409
49Reduced antithrombin III activity (HP:0001976)2.81571620
50Abnormality of iron homeostasis (HP:0011031)2.80995019
51Increased serum ferritin (HP:0003281)2.79122090
52Abnormal foot bone ossification (HP:0010675)2.76346919
53Long foot (HP:0001833)2.75406426
54Abnormality of the prostate (HP:0008775)2.72861656
55Epistaxis (HP:0000421)2.68297429
56Prolonged bleeding time (HP:0003010)2.67117755
57Abnormality of the pons (HP:0007361)2.66941971
58Bicuspid aortic valve (HP:0001647)2.62719330
59Abnormal platelet volume (HP:0011876)2.62321287
60Abnormal protein glycosylation (HP:0012346)2.58690593
61Abnormal glycosylation (HP:0012345)2.58690593
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58690593
63Abnormal protein N-linked glycosylation (HP:0012347)2.58690593
64Pancreatitis (HP:0001733)2.58688611
65Autoimmune hemolytic anemia (HP:0001890)2.58449875
66Abnormality of the intrinsic pathway (HP:0010989)2.57319415
67Abnormal platelet function (HP:0011869)2.56372506
68Impaired platelet aggregation (HP:0003540)2.56372506
69Colitis (HP:0002583)2.52625126
70Hypochromic microcytic anemia (HP:0004840)2.51917412
71Ankle contracture (HP:0006466)2.51026979
72Gastrointestinal infarctions (HP:0005244)2.50969342
73Increased IgM level (HP:0003496)2.50680165
74Abnormality of the calcaneus (HP:0008364)2.48927999
75Abnormality of T cells (HP:0002843)2.45784808
76Abnormality of transition element cation homeostasis (HP:0011030)2.45386128
77Type I diabetes mellitus (HP:0100651)2.44973691
78Increased cerebral lipofuscin (HP:0011813)2.44395545
79Autoimmune thrombocytopenia (HP:0001973)2.44008543
80Acute lymphatic leukemia (HP:0006721)2.42483253
81Increased mean platelet volume (HP:0011877)2.41922081
82Gingivitis (HP:0000230)2.40938034
83Myositis (HP:0100614)2.38177822
84Increased neuronal autofluorescent lipopigment (HP:0002074)2.38090513
85Hemoptysis (HP:0002105)2.37076996
86Broad face (HP:0000283)2.36833875
87Hypergammaglobulinemia (HP:0010702)2.36505507
88Keratoconjunctivitis sicca (HP:0001097)2.33499328
89Pulmonary infiltrates (HP:0002113)2.32476543
90Type I transferrin isoform profile (HP:0003642)2.31327434
91Reticulocytopenia (HP:0001896)2.29640905
92Centrally nucleated skeletal muscle fibers (HP:0003687)2.28109025
93Premature skin wrinkling (HP:0100678)2.26527873
94Aneurysm (HP:0002617)2.25864187
95Elevated erythrocyte sedimentation rate (HP:0003565)2.25461116
96Osteolytic defects of the phalanges of the hand (HP:0009771)2.24330812
97Osteolytic defects of the hand bones (HP:0009699)2.24330812
98Bruising susceptibility (HP:0000978)2.23853575
99Recurrent abscess formation (HP:0002722)2.22940246
100Recurrent bacterial skin infections (HP:0005406)2.21550119
101Selective tooth agenesis (HP:0001592)2.21011548
102Pulmonary embolism (HP:0002204)2.20751768
103Exocrine pancreatic insufficiency (HP:0001738)2.20745069
104Hypochromic anemia (HP:0001931)2.20629593
105Osteomyelitis (HP:0002754)2.19939259
106Amaurosis fugax (HP:0100576)2.19756754
107Viral hepatitis (HP:0006562)2.19601664
108Eosinophilia (HP:0001880)2.19474228
109Pustule (HP:0200039)2.19029310
110Amyloidosis (HP:0011034)2.16967091
111Menorrhagia (HP:0000132)2.15828422
112Nonimmune hydrops fetalis (HP:0001790)2.15685232
113Vertigo (HP:0002321)2.15063921
114Keratoconjunctivitis (HP:0001096)2.12821226
115Neoplasm of the heart (HP:0100544)2.12279009
116Skin rash (HP:0000988)2.11347796
117Hypertensive crisis (HP:0100735)2.10763218
118Purpura (HP:0000979)2.09049431
119Thoracic kyphosis (HP:0002942)2.08698836
120Spontaneous hematomas (HP:0007420)2.08644227
121Cerebral aneurysm (HP:0004944)2.05250729
122Recurrent viral infections (HP:0004429)2.04920779
123Microcytic anemia (HP:0001935)2.04199167
124Abnormality of T cell physiology (HP:0011840)2.04017189
125Arterial thrombosis (HP:0004420)2.03507003
126Sepsis (HP:0100806)2.01862269
127Abnormality of the heme biosynthetic pathway (HP:0010472)2.01777382
128Malnutrition (HP:0004395)2.01644328
129Poikiloderma (HP:0001029)2.01012117
130Polycythemia (HP:0001901)2.00785210
131Thrombophlebitis (HP:0004418)2.00417651
132Congenital hip dislocation (HP:0001374)2.00189208
133Gastrointestinal inflammation (HP:0004386)1.99977016
134Skin ulcer (HP:0200042)1.97041176
135Beaking of vertebral bodies (HP:0004568)1.96900379
136Acute hepatic failure (HP:0006554)1.95787107
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94930491
138Spastic diplegia (HP:0001264)1.94560987
139Calcaneovalgus deformity (HP:0001848)1.90207813
140Abnormality of the thoracic spine (HP:0100711)1.89040335
141Maternal diabetes (HP:0009800)1.86495648
142Gangrene (HP:0100758)1.85374836
143Abnormality of T cell number (HP:0011839)1.84664458
144Abnormal delayed hypersensitivity skin test (HP:0002963)1.83603005
145Chest pain (HP:0100749)1.83400098
146Progressive muscle weakness (HP:0003323)1.83188818
147Chronic otitis media (HP:0000389)1.83090154
148Abnormality of the nasal mucosa (HP:0000433)1.82262274
149Inflammation of the large intestine (HP:0002037)1.81572659
150Anorexia (HP:0002039)1.81405493
151Gingival bleeding (HP:0000225)1.81320984
152Deformed tarsal bones (HP:0008119)1.80347296
153Polygenic inheritance (HP:0010982)1.80341817
154Microretrognathia (HP:0000308)1.79940091
155Short 4th metacarpal (HP:0010044)1.79167029
156Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79167029
157T lymphocytopenia (HP:0005403)1.79075162
158Dysostosis multiplex (HP:0000943)1.78597003
159Abnormality of the pleura (HP:0002103)1.78191843
160Abnormality of B cell number (HP:0010975)1.78032493
161B lymphocytopenia (HP:0010976)1.78032493
162Biconcave vertebral bodies (HP:0004586)1.76246082
163Interstitial pulmonary disease (HP:0006530)1.74589471
164Eczematoid dermatitis (HP:0000976)1.73704116
165Periodontitis (HP:0000704)1.73046665
166Abnormality of the lumbar spine (HP:0100712)1.71634314
167Coxa valga (HP:0002673)1.71634242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK5.80494900
2BCKDK5.26342701
3RIPK44.83161588
4ERN14.23274073
5TTN3.52090837
6PKN23.26749631
7EEF2K2.65112251
8KIT2.56819898
9PIK3CG2.55157923
10PAK22.46732232
11TNK22.39229150
12TRIB32.27072798
13ZAP702.10793263
14EIF2AK32.04000308
15PRPF4B2.03550993
16MAP4K11.88739459
17NME21.86997490
18RPS6KB21.86145698
19MAP2K21.81559282
20MAPKAPK31.80215880
21TGFBR11.76852573
22TIE11.75910378
23TGFBR21.71328861
24TESK21.62650152
25BTK1.62529489
26FLT31.61531652
27MAP3K111.59712334
28CSK1.55847864
29SCYL21.55668722
30TAOK31.46783846
31MAP2K31.45301513
32BMPR21.42841947
33ITK1.42746873
34IKBKB1.40312369
35MAP3K141.40239097
36MATK1.37514083
37LRRK21.20191968
38TEC1.18610207
39CAMKK21.13171480
40MAP3K11.08626372
41TBK11.07397367
42FGR1.06761044
43JAK31.04775967
44DMPK1.04610228
45MAP3K31.03319269
46TAOK21.03297600
47TAOK10.99394885
48ILK0.96864224
49STK160.96843938
50IRAK10.93002359
51IRAK30.92692091
52BMX0.92196307
53PTK60.91766409
54MAP4K20.90767377
55MARK30.90317963
56RAF10.87439282
57MAP2K60.86523712
58KDR0.86029222
59WEE10.85640238
60MAP3K130.83947420
61PIK3CA0.83447702
62MARK20.79511789
63PTK2B0.77941016
64IRAK40.76569845
65ACVR1B0.75522999
66PIM20.75517503
67MAPKAPK50.73557955
68PASK0.73141946
69JAK10.73109315
70PDK10.73094372
71SIK30.73079863
72TYK20.71648009
73IRAK20.69688535
74CLK10.69125016
75PIM10.69031456
76DAPK20.68447759
77MAP3K50.68187558
78SYK0.67767855
79CDK80.67554875
80PRKCQ0.66956136
81MAPK40.66598151
82NUAK10.66525284
83MAPK120.65651344
84CCNB10.62702393
85CDK190.61366719
86PDGFRB0.59279220
87TXK0.58686554
88MAP3K60.58561132
89PDPK10.58212404
90RPS6KA60.58056301
91FES0.57103069
92MAP2K10.57010916
93PRKD20.55815815
94CAMKK10.54856276
95CAMK10.53948647
96PAK40.53315618
97CAMK1D0.53202040
98LYN0.52855031
99RPS6KL10.51046925
100RPS6KC10.51046925
101RET0.50970018
102RPS6KA40.50714739
103DAPK30.49432634
104EPHB10.49087963
105FYN0.47633842
106PAK10.45705952
107NEK90.45031590
108MAP3K80.44941075
109BRSK20.44062431
110PDGFRA0.42660880
111MAPK70.42483199
112DYRK1B0.42059308
113VRK20.41653512
114LCK0.41251800
115CDK40.40747151
116MAPKAPK20.40194663
117GRK60.39761013
118GRK50.39545847
119RPS6KA20.39414846
120VRK10.38995254
121YES10.38083319
122TSSK60.37930005
123PRKCD0.37744915
124CSF1R0.37491958
125TRPM70.37128345
126GRK70.36417933
127STK100.35863436
128MAPK30.34803346
129RIPK10.34208504
130ABL10.33941225
131PRKACB0.33318361
132MAPK110.32770831
133PRKD10.31283288
134ATR0.30644935
135JAK20.30557333
136IKBKE0.29938801
137MAP2K40.29007913
138HIPK20.28438252
139PRKG20.28285641
140CDK60.28149853
141MAP3K70.27232415
142SMG10.26055944
143HCK0.25177778
144BLK0.24326407
145CDC70.23389343
146DAPK10.23296223

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049726.63945745
2Protein digestion and absorption_Homo sapiens_hsa049744.87470626
3Fat digestion and absorption_Homo sapiens_hsa049754.30541550
4Protein export_Homo sapiens_hsa030603.06200859
5Ribosome_Homo sapiens_hsa030102.83320096
6Folate biosynthesis_Homo sapiens_hsa007902.80144247
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.76850164
8Allograft rejection_Homo sapiens_hsa053302.76645956
9Staphylococcus aureus infection_Homo sapiens_hsa051502.68188920
10Graft-versus-host disease_Homo sapiens_hsa053322.58250786
11Autoimmune thyroid disease_Homo sapiens_hsa053202.46273654
12DNA replication_Homo sapiens_hsa030302.35276806
13Glycerolipid metabolism_Homo sapiens_hsa005612.26940349
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.24699323
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.06472905
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.02131935
17Type I diabetes mellitus_Homo sapiens_hsa049402.01673633
18Other glycan degradation_Homo sapiens_hsa005111.99810504
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99434423
20Tuberculosis_Homo sapiens_hsa051521.94106934
21N-Glycan biosynthesis_Homo sapiens_hsa005101.89655542
22Renin-angiotensin system_Homo sapiens_hsa046141.80229902
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71698045
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70640325
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.69952796
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68235574
27Malaria_Homo sapiens_hsa051441.56018602
28Mismatch repair_Homo sapiens_hsa034301.43027598
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41790163
30Viral myocarditis_Homo sapiens_hsa054161.41628236
31Chemokine signaling pathway_Homo sapiens_hsa040621.39228271
32Influenza A_Homo sapiens_hsa051641.28490441
33Propanoate metabolism_Homo sapiens_hsa006401.26703768
34Rheumatoid arthritis_Homo sapiens_hsa053231.24646606
35T cell receptor signaling pathway_Homo sapiens_hsa046601.22539790
36Phagosome_Homo sapiens_hsa041451.13834995
37Legionellosis_Homo sapiens_hsa051341.12496550
38Leishmaniasis_Homo sapiens_hsa051401.10117230
39African trypanosomiasis_Homo sapiens_hsa051431.09057699
40* Platelet activation_Homo sapiens_hsa046111.07638059
41Notch signaling pathway_Homo sapiens_hsa043301.07180903
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04202479
43Base excision repair_Homo sapiens_hsa034101.04191960
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01847209
45One carbon pool by folate_Homo sapiens_hsa006700.94526328
46Arachidonic acid metabolism_Homo sapiens_hsa005900.93238379
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91228437
48Vitamin digestion and absorption_Homo sapiens_hsa049770.90662828
49Biosynthesis of amino acids_Homo sapiens_hsa012300.88979401
50TNF signaling pathway_Homo sapiens_hsa046680.88788984
51Sulfur relay system_Homo sapiens_hsa041220.88504276
52Pyrimidine metabolism_Homo sapiens_hsa002400.82766242
53Regulation of autophagy_Homo sapiens_hsa041400.81284649
54Systemic lupus erythematosus_Homo sapiens_hsa053220.76626781
55Thyroid cancer_Homo sapiens_hsa052160.76610460
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.76358560
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75677387
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.74947694
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74856839
60Salmonella infection_Homo sapiens_hsa051320.73245918
61Hematopoietic cell lineage_Homo sapiens_hsa046400.72414078
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71973281
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71586961
64Toxoplasmosis_Homo sapiens_hsa051450.70701526
65Acute myeloid leukemia_Homo sapiens_hsa052210.70353623
66Hepatitis C_Homo sapiens_hsa051600.70262463
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.69751616
68Pentose phosphate pathway_Homo sapiens_hsa000300.69634478
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68347962
70B cell receptor signaling pathway_Homo sapiens_hsa046620.68299969
71Antigen processing and presentation_Homo sapiens_hsa046120.68096650
72Primary immunodeficiency_Homo sapiens_hsa053400.67205323
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66378141
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65472755
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64240014
76Viral carcinogenesis_Homo sapiens_hsa052030.63486305
77Herpes simplex infection_Homo sapiens_hsa051680.62973526
78Measles_Homo sapiens_hsa051620.61879365
79Selenocompound metabolism_Homo sapiens_hsa004500.61342680
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.59822402
81Endocytosis_Homo sapiens_hsa041440.57104188
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.57068286
83Amoebiasis_Homo sapiens_hsa051460.56856366
84Bladder cancer_Homo sapiens_hsa052190.55736573
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55198431
86Caffeine metabolism_Homo sapiens_hsa002320.54617540
87Small cell lung cancer_Homo sapiens_hsa052220.53330985
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.53148739
89Starch and sucrose metabolism_Homo sapiens_hsa005000.53068338
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52762320
91Pertussis_Homo sapiens_hsa051330.51655501
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.51365763
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50264286
94Hepatitis B_Homo sapiens_hsa051610.49671422
95Shigellosis_Homo sapiens_hsa051310.49300357
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.48988754
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46797455
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.45972148
99Inositol phosphate metabolism_Homo sapiens_hsa005620.45916349
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45151136
101Non-small cell lung cancer_Homo sapiens_hsa052230.44757897
102Apoptosis_Homo sapiens_hsa042100.43377480
103HTLV-I infection_Homo sapiens_hsa051660.43374933
104Glutathione metabolism_Homo sapiens_hsa004800.42197986
105Choline metabolism in cancer_Homo sapiens_hsa052310.42152301
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42142811
107Arginine and proline metabolism_Homo sapiens_hsa003300.41989544
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41565414
109Prolactin signaling pathway_Homo sapiens_hsa049170.41536012
110RNA polymerase_Homo sapiens_hsa030200.41479534
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40950921
112Nucleotide excision repair_Homo sapiens_hsa034200.40321604
113Osteoclast differentiation_Homo sapiens_hsa043800.40046370
114Pancreatic cancer_Homo sapiens_hsa052120.39887486
115Galactose metabolism_Homo sapiens_hsa000520.39671338
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39611121
117beta-Alanine metabolism_Homo sapiens_hsa004100.38408159
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37796926
119Epstein-Barr virus infection_Homo sapiens_hsa051690.37697873
120VEGF signaling pathway_Homo sapiens_hsa043700.37552282
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35390875
122Focal adhesion_Homo sapiens_hsa045100.34641332
123Chronic myeloid leukemia_Homo sapiens_hsa052200.34162083
124Homologous recombination_Homo sapiens_hsa034400.34099000
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.33707910
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33387695
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32806890
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32758683
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32629300
130Linoleic acid metabolism_Homo sapiens_hsa005910.32092977
131Asthma_Homo sapiens_hsa053100.31053303
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.29546239
133Purine metabolism_Homo sapiens_hsa002300.29291756
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.28683951
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.28185975
136Lysosome_Homo sapiens_hsa041420.27955322
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27063168
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26983221
139Spliceosome_Homo sapiens_hsa030400.26820276
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25986560
141Insulin resistance_Homo sapiens_hsa049310.22529956
142MAPK signaling pathway_Homo sapiens_hsa040100.22387589
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21333384
144Olfactory transduction_Homo sapiens_hsa047400.21320868
145Dorso-ventral axis formation_Homo sapiens_hsa043200.20437415
146FoxO signaling pathway_Homo sapiens_hsa040680.19631904
147GnRH signaling pathway_Homo sapiens_hsa049120.19340966

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