P2RX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)7.97979663
2positive regulation of potassium ion transmembrane transporter activity (GO:1901018)7.60268015
3regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)7.60257925
4neurofilament cytoskeleton organization (GO:0060052)7.24482128
5bundle of His cell to Purkinje myocyte communication (GO:0086069)6.59759134
6detection of temperature stimulus (GO:0016048)6.50240603
7pyrimidine nucleobase catabolic process (GO:0006208)6.45160038
8behavioral response to nicotine (GO:0035095)6.30026655
9detection of temperature stimulus involved in sensory perception of pain (GO:0050965)6.17900480
10detection of temperature stimulus involved in sensory perception (GO:0050961)6.17900480
11* neuronal action potential (GO:0019228)6.07132768
12membrane depolarization during action potential (GO:0086010)5.65905284
13negative regulation of complement activation (GO:0045916)5.50049348
14positive regulation of potassium ion transmembrane transport (GO:1901381)5.46805196
15adenosine metabolic process (GO:0046085)5.19243159
16nucleobase catabolic process (GO:0046113)5.18840172
17enteric nervous system development (GO:0048484)5.16977375
18negative regulation of dendrite development (GO:2000171)5.08549449
19regulation of cell maturation (GO:1903429)5.01848937
20peripheral nervous system neuron development (GO:0048935)4.94224719
21acrosome reaction (GO:0007340)4.90583285
22cellular response to ATP (GO:0071318)4.87817204
23response to pheromone (GO:0019236)4.84555686
24positive regulation of muscle hypertrophy (GO:0014742)4.76082391
25positive regulation of cardiac muscle hypertrophy (GO:0010613)4.76082391
26negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.72710689
27proline transport (GO:0015824)4.69317943
28* response to pain (GO:0048265)4.67215209
29negative regulation of protein activation cascade (GO:2000258)4.60385128
30negative regulation of microtubule polymerization (GO:0031115)4.48068867
31cell migration in hindbrain (GO:0021535)4.46305692
32positive regulation of synaptic transmission, GABAergic (GO:0032230)4.46249251
33regulation of platelet aggregation (GO:0090330)4.43983999
34sperm motility (GO:0030317)4.36389887
35axon cargo transport (GO:0008088)4.31339336
36cell communication involved in cardiac conduction (GO:0086065)4.30689890
37negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.17626884
38positive regulation of potassium ion transport (GO:0043268)3.98891548
39* behavioral response to pain (GO:0048266)3.96926440
40regulation of cilium movement (GO:0003352)3.96082157
41presynaptic membrane organization (GO:0097090)3.93672887
42alanine transport (GO:0032328)3.92899073
43response to water (GO:0009415)3.90645167
44regulation of glucocorticoid metabolic process (GO:0031943)3.88587935
45regulation of potassium ion transmembrane transporter activity (GO:1901016)3.88581419
46negative regulation of homotypic cell-cell adhesion (GO:0034111)3.86495533
47negative regulation of humoral immune response (GO:0002921)3.78272455
48negative regulation of cell size (GO:0045792)3.75443071
49synaptic transmission, cholinergic (GO:0007271)3.74280425
50establishment of mitochondrion localization (GO:0051654)3.73143627
51nonmotile primary cilium assembly (GO:0035058)3.71874479
52calcium ion-dependent exocytosis (GO:0017156)3.66839264
53positive regulation of cell size (GO:0045793)3.66644440
54postsynaptic membrane organization (GO:0001941)3.56694289
55detection of mechanical stimulus involved in sensory perception (GO:0050974)3.56147097
56auditory behavior (GO:0031223)3.55800348
57axonal fasciculation (GO:0007413)3.54108403
58regulation of potassium ion transmembrane transport (GO:1901379)3.51035791
59behavioral response to ethanol (GO:0048149)3.49836934
60L-serine transport (GO:0015825)3.49691903
61membrane repolarization (GO:0086009)3.48112529
62epithelial cilium movement (GO:0003351)3.46890735
63regulation of translational termination (GO:0006449)3.42987109
64negative regulation of cytosolic calcium ion concentration (GO:0051481)3.41221315
65cellular ketone body metabolic process (GO:0046950)3.38863615
66regulation of amyloid precursor protein catabolic process (GO:1902991)3.38680668
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37839529
68sodium ion transmembrane transport (GO:0035725)3.37707264
69negative regulation of calcium ion transport into cytosol (GO:0010523)3.37482296
70cellular response to prostaglandin stimulus (GO:0071379)3.35978234
71negative regulation of sodium ion transport (GO:0010766)3.34612117
72presynaptic membrane assembly (GO:0097105)3.32800764
73synaptic vesicle maturation (GO:0016188)3.31763244
74establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.31175145
75mitochondrion transport along microtubule (GO:0047497)3.31175145
76protein polyglutamylation (GO:0018095)3.30540458
77organelle transport along microtubule (GO:0072384)3.30256076
78neuron cell-cell adhesion (GO:0007158)3.30187883
79potassium ion export (GO:0071435)3.29461567
80vesicle transport along microtubule (GO:0047496)3.28776493
81regulation of microtubule-based movement (GO:0060632)3.27234280
82retinal ganglion cell axon guidance (GO:0031290)3.25479096
83positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25329920
84* neuromuscular synaptic transmission (GO:0007274)3.24923629
85membrane budding (GO:0006900)3.24836057
86positive regulation of amino acid transport (GO:0051957)3.24128972
87spermatid development (GO:0007286)3.23937115
88protein localization to synapse (GO:0035418)3.22868553
89regulation of synaptic vesicle exocytosis (GO:2000300)3.22698703
90regulation of glucocorticoid secretion (GO:2000849)3.22052250
91positive regulation of growth hormone secretion (GO:0060124)3.22040197
92regulation of NFAT protein import into nucleus (GO:0051532)3.21655119
93single strand break repair (GO:0000012)3.20035527
94glutamate secretion (GO:0014047)3.19929817
95spinal cord motor neuron differentiation (GO:0021522)3.19047615
96positive regulation of hair cycle (GO:0042635)3.17378755
97positive regulation of hair follicle development (GO:0051798)3.17378755
98intermediate filament-based process (GO:0045103)3.17251623
99substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.16754388
100substrate-independent telencephalic tangential migration (GO:0021826)3.16754388
101plasma membrane repair (GO:0001778)3.16666824
102intermediate filament cytoskeleton organization (GO:0045104)3.16383862
103cell differentiation in spinal cord (GO:0021515)3.16026691
104regulation of hair follicle development (GO:0051797)3.15612421
105regulation of synapse structural plasticity (GO:0051823)3.15336929
106* action potential (GO:0001508)3.13272000
107phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.12821883
108regulation of homotypic cell-cell adhesion (GO:0034110)3.12589611
109regulation of action potential (GO:0098900)3.11646674
110regulation of sensory perception of pain (GO:0051930)3.09271461
111regulation of sensory perception (GO:0051931)3.09271461
112transmission of nerve impulse (GO:0019226)3.08687531
113axonemal dynein complex assembly (GO:0070286)3.07974971
114serine transport (GO:0032329)3.05875792
115sodium ion export (GO:0071436)3.04787877
116regulation of collateral sprouting (GO:0048670)3.03497794
117regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02190724
118G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01564395
119innervation (GO:0060384)3.01050938
120cornea development in camera-type eye (GO:0061303)3.00541633
121ketone body metabolic process (GO:1902224)2.99171144
122synapse assembly (GO:0007416)2.99026903
123activation of protein kinase A activity (GO:0034199)2.98258902
124positive regulation of glomerulus development (GO:0090193)2.96548640
125negative regulation of protein polymerization (GO:0032272)2.96301787
126cellular potassium ion homeostasis (GO:0030007)2.96120099
127positive regulation of steroid hormone secretion (GO:2000833)2.95956347
128negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95705464
129positive regulation of mitochondrial fission (GO:0090141)2.95462852
130chemosensory behavior (GO:0007635)2.95180539
131regulation of membrane depolarization (GO:0003254)2.95093115
132central nervous system projection neuron axonogenesis (GO:0021952)2.93367575
133neuronal action potential propagation (GO:0019227)2.92640709
134positive regulation of action potential (GO:0045760)2.92541422
135actin filament capping (GO:0051693)2.92211238
136neuron recognition (GO:0008038)2.91281985
137neuronal ion channel clustering (GO:0045161)2.90324860
138* response to ATP (GO:0033198)2.90085798
139antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.89543480
140intermediate filament organization (GO:0045109)2.88004801
141mechanosensory behavior (GO:0007638)2.87568677
142C4-dicarboxylate transport (GO:0015740)2.85966782
143cilium movement (GO:0003341)2.85131216
144regulation of sodium ion transmembrane transporter activity (GO:2000649)2.84512373
145hindbrain development (GO:0030902)2.84042775
146antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.83395225
147antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)2.83395225
148microtubule depolymerization (GO:0007019)2.78190775
149multicellular organism reproduction (GO:0032504)2.77109667
150calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.76093378
151spermatid nucleus differentiation (GO:0007289)2.75457944
152forebrain neuron differentiation (GO:0021879)2.75081902
153spinal cord association neuron differentiation (GO:0021527)2.70887015
154cilium organization (GO:0044782)2.68729569
155cilium assembly (GO:0042384)2.68504355
156somite development (GO:0061053)2.67323950
157glutamate receptor signaling pathway (GO:0007215)2.65547128
158tachykinin receptor signaling pathway (GO:0007217)2.65421134
159ionotropic glutamate receptor signaling pathway (GO:0035235)2.64896987
160limb bud formation (GO:0060174)2.63142694
161dendritic spine morphogenesis (GO:0060997)2.61167111
162microtubule severing (GO:0051013)2.61024256
163cilium or flagellum-dependent cell motility (GO:0001539)2.58520056
164detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56842658
165positive regulation of gastrulation (GO:2000543)2.53698077
166fusion of sperm to egg plasma membrane (GO:0007342)2.50928965
167kidney morphogenesis (GO:0060993)2.50285563
168detection of light stimulus involved in visual perception (GO:0050908)2.48045013
169detection of light stimulus involved in sensory perception (GO:0050962)2.48045013
170central nervous system neuron axonogenesis (GO:0021955)2.48018447
171regulation of growth hormone secretion (GO:0060123)2.46230818
172neural tube formation (GO:0001841)2.43521723
173sperm-egg recognition (GO:0035036)2.43047620
174response to auditory stimulus (GO:0010996)2.42841735
175gamma-aminobutyric acid transport (GO:0015812)2.42618233
176spinal cord development (GO:0021510)2.41977829
177vocalization behavior (GO:0071625)2.41797718
178adult walking behavior (GO:0007628)2.41775265
179establishment of protein localization to Golgi (GO:0072600)2.40357232
180positive regulation of oligodendrocyte differentiation (GO:0048714)2.39961767
181neuron fate determination (GO:0048664)2.39549088
182somite rostral/caudal axis specification (GO:0032525)2.38901841
183sequestering of actin monomers (GO:0042989)2.38807238
184cranial nerve development (GO:0021545)2.38273327
185positive regulation of synapse assembly (GO:0051965)2.38069294
186regulation of timing of cell differentiation (GO:0048505)2.37883183
187startle response (GO:0001964)2.37595701
188L-fucose metabolic process (GO:0042354)2.37449334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.39753508
2ZNF263_19887448_ChIP-Seq_K562_Human3.36145980
3ESR2_21235772_ChIP-Seq_MCF-7_Human2.75135535
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.65699459
5IGF1R_20145208_ChIP-Seq_DFB_Human2.61253745
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.47231993
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44389729
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39631062
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.33789233
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27266379
11REST_21632747_ChIP-Seq_MESCs_Mouse2.25706671
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20437046
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.17110851
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15502305
15VDR_22108803_ChIP-Seq_LS180_Human2.14032811
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13609839
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10850589
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03372517
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03372517
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03202617
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02447166
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00653589
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99005734
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.98807744
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.91987673
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88056683
27* CTCF_27219007_Chip-Seq_Bcells_Human1.85984843
28RNF2_27304074_Chip-Seq_NSC_Mouse1.84712914
29FUS_26573619_Chip-Seq_HEK293_Human1.84476889
30P300_19829295_ChIP-Seq_ESCs_Human1.82719175
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81818869
32NR3C1_23031785_ChIP-Seq_PC12_Mouse1.81175759
33ZNF274_21170338_ChIP-Seq_K562_Hela1.78143137
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76612116
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76456649
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.76456649
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75214075
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73887919
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73044865
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72755262
41EGR1_19032775_ChIP-ChIP_M12_Human1.72067509
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.70313072
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70210708
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67590896
45KDM2B_26808549_Chip-Seq_K562_Human1.64336320
46TAF15_26573619_Chip-Seq_HEK293_Human1.63401094
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58547828
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.54287817
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53286871
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.50143068
51SMAD4_21799915_ChIP-Seq_A2780_Human1.49683853
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47779892
53AHR_22903824_ChIP-Seq_MCF-7_Human1.46938222
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.46025022
55TET1_21490601_ChIP-Seq_MESCs_Mouse1.45764425
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.45450839
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45387391
58EWS_26573619_Chip-Seq_HEK293_Human1.45256326
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43713409
60CBP_20019798_ChIP-Seq_JUKART_Human1.43713409
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43357904
62ER_23166858_ChIP-Seq_MCF-7_Human1.41729573
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41712821
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.38833525
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36680235
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35808965
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35426559
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34241083
69IRF1_19129219_ChIP-ChIP_H3396_Human1.31188920
70AR_25329375_ChIP-Seq_VCAP_Human1.31084168
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30778499
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30211481
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28537986
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26204620
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.25870736
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25611156
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25419647
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24684069
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24519686
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.24071169
81GBX2_23144817_ChIP-Seq_PC3_Human1.22377079
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21492758
83AR_21572438_ChIP-Seq_LNCaP_Human1.21036658
84SMAD3_21741376_ChIP-Seq_ESCs_Human1.20241465
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19695765
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18428616
87DROSHA_22980978_ChIP-Seq_HELA_Human1.17964603
88STAT3_23295773_ChIP-Seq_U87_Human1.17638902
89RARB_27405468_Chip-Seq_BRAIN_Mouse1.17542614
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.17361051
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16750347
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16401228
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15981606
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15883888
95EZH2_27304074_Chip-Seq_ESCs_Mouse1.15817748
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15367534
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13901842
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13705176
99TP53_22573176_ChIP-Seq_HFKS_Human1.13613586
100RUNX2_22187159_ChIP-Seq_PCA_Human1.13469453
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12531932
102TCF4_23295773_ChIP-Seq_U87_Human1.12389267
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12174374
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11476981
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10879698
106KDM2B_26808549_Chip-Seq_REH_Human1.10305537
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09895740
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09866715
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09479885
110KLF4_19829295_ChIP-Seq_ESCs_Human1.07848646
111BCAT_22108803_ChIP-Seq_LS180_Human1.06007730
112P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05465273
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05017967
114RING1B_27294783_Chip-Seq_ESCs_Mouse1.04864326
115TP63_19390658_ChIP-ChIP_HaCaT_Human1.03997846
116* LXR_22292898_ChIP-Seq_THP-1_Human1.03537845
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02949171
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02187586
119NANOG_19829295_ChIP-Seq_ESCs_Human1.01842113
120SOX2_19829295_ChIP-Seq_ESCs_Human1.01842113
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01002888
122ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00722014
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00608999
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.00472330
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00248197
126RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00229361
127ESR1_21235772_ChIP-Seq_MCF-7_Human1.00105320
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99868171
129NANOG_18555785_Chip-Seq_ESCs_Mouse0.99212213
130ERA_21632823_ChIP-Seq_H3396_Human0.98841291
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.98308076
132* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96833684
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95648494
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95065771
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94523270
136GATA3_21878914_ChIP-Seq_MCF-7_Human0.93836583
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93587487
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.93426185
139SOX2_21211035_ChIP-Seq_LN229_Human0.93419963
140JUN_21703547_ChIP-Seq_K562_Human0.93241464
141FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93070766
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92925172
143KDM2B_26808549_Chip-Seq_DND41_Human0.92773952
144FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92564090
145GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90857665
146EP300_21415370_ChIP-Seq_HL-1_Mouse0.89194660
147GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88728774
148CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87806003
149AR_19668381_ChIP-Seq_PC3_Human0.87805941
150SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87732954
151SPI1_23127762_ChIP-Seq_K562_Human0.87254316
152ELK3_25401928_ChIP-Seq_HUVEC_Human0.86895553
153JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.86800918
154YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83937615
155ELF1_20517297_ChIP-Seq_JURKAT_Human0.83367854
156YY1_22570637_ChIP-Seq_MALME-3M_Human0.83360830
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.83347722
158FOXH1_21741376_ChIP-Seq_ESCs_Human0.83116048
159GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82485513
160ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82244382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after8.19275250
2* MP0001968_abnormal_touch/_nociception7.47386774
3* MP0002735_abnormal_chemical_nociception7.26345022
4MP0001986_abnormal_taste_sensitivity6.20848795
5MP0004858_abnormal_nervous_system5.60460825
6* MP0002733_abnormal_thermal_nociception4.37184075
7MP0002734_abnormal_mechanical_nocicepti4.25985326
8MP0004270_analgesia3.70736907
9MP0006276_abnormal_autonomic_nervous3.55210245
10MP0002822_catalepsy3.43936279
11* MP0001970_abnormal_pain_threshold3.39795436
12MP0001529_abnormal_vocalization2.73188306
13MP0002163_abnormal_gland_morphology2.42834037
14MP0002751_abnormal_autonomic_nervous2.26016221
15MP0001188_hyperpigmentation2.24433132
16MP0005645_abnormal_hypothalamus_physiol2.21502955
17MP0003787_abnormal_imprinting2.17887002
18MP0008789_abnormal_olfactory_epithelium2.08703088
19MP0005394_taste/olfaction_phenotype2.01820182
20MP0005499_abnormal_olfactory_system2.01820182
21MP0002102_abnormal_ear_morphology2.00442749
22MP0008877_abnormal_DNA_methylation1.97221434
23MP0003329_amyloid_beta_deposits1.94219703
24MP0003656_abnormal_erythrocyte_physiolo1.88214813
25MP0002653_abnormal_ependyma_morphology1.83753169
26MP0002638_abnormal_pupillary_reflex1.80433343
27MP0002938_white_spotting1.74123028
28MP0006292_abnormal_olfactory_placode1.73897865
29MP0002184_abnormal_innervation1.73569010
30* MP0002272_abnormal_nervous_system1.71045452
31MP0004859_abnormal_synaptic_plasticity1.69511181
32MP0003136_yellow_coat_color1.66959585
33* MP0002067_abnormal_sensory_capabilities1.64380361
34MP0003011_delayed_dark_adaptation1.64159592
35MP0004885_abnormal_endolymph1.59161212
36MP0001486_abnormal_startle_reflex1.58879825
37MP0003122_maternal_imprinting1.57456449
38MP0005551_abnormal_eye_electrophysiolog1.54525408
39MP0004133_heterotaxia1.50573153
40MP0004811_abnormal_neuron_physiology1.50165379
41MP0004742_abnormal_vestibular_system1.45991855
42MP0005253_abnormal_eye_physiology1.45818906
43MP0002234_abnormal_pharynx_morphology1.40422165
44MP0008260_abnormal_autophagy1.38785013
45MP0003121_genomic_imprinting1.37983236
46MP0001905_abnormal_dopamine_level1.36262557
47MP0005379_endocrine/exocrine_gland_phen1.35928249
48MP0001348_abnormal_lacrimal_gland1.35881209
49MP0001485_abnormal_pinna_reflex1.32809659
50MP0005083_abnormal_biliary_tract1.32773693
51MP0001270_distended_abdomen1.31783866
52MP0000566_synostosis1.31775564
53MP0000631_abnormal_neuroendocrine_gland1.31025348
54MP0006072_abnormal_retinal_apoptosis1.29662437
55MP0003635_abnormal_synaptic_transmissio1.26841029
56MP0000955_abnormal_spinal_cord1.22721555
57MP0005084_abnormal_gallbladder_morpholo1.22281487
58MP0002928_abnormal_bile_duct1.21629052
59MP0000604_amyloidosis1.19184256
60MP0000427_abnormal_hair_cycle1.16186246
61MP0003119_abnormal_digestive_system1.15220762
62MP0003878_abnormal_ear_physiology1.12910699
63MP0005377_hearing/vestibular/ear_phenot1.12910699
64MP0005187_abnormal_penis_morphology1.10108827
65MP0005423_abnormal_somatic_nervous1.08826086
66MP0010386_abnormal_urinary_bladder1.08273272
67MP0000026_abnormal_inner_ear1.06805302
68MP0002876_abnormal_thyroid_physiology1.04706278
69MP0005410_abnormal_fertilization1.03939342
70MP0001929_abnormal_gametogenesis1.01819605
71MP0005195_abnormal_posterior_eye1.00640198
72MP0000049_abnormal_middle_ear0.97616354
73* MP0010771_integument_phenotype0.94926220
74MP0009046_muscle_twitch0.93436942
75MP0003137_abnormal_impulse_conducting0.91807515
76MP0002233_abnormal_nose_morphology0.89590925
77MP0000538_abnormal_urinary_bladder0.88686333
78MP0005171_absent_coat_pigmentation0.88456271
79MP0005391_vision/eye_phenotype0.86048865
80MP0002152_abnormal_brain_morphology0.85753249
81MP0000747_muscle_weakness0.85406528
82MP0002882_abnormal_neuron_morphology0.84798911
83MP0003938_abnormal_ear_development0.84230014
84MP0003880_abnormal_central_pattern0.84124741
85MP0003183_abnormal_peptide_metabolism0.83060602
86MP0003195_calcinosis0.82948777
87MP0005646_abnormal_pituitary_gland0.82915799
88MP0003861_abnormal_nervous_system0.82437204
89MP0000534_abnormal_ureter_morphology0.81325565
90MP0002063_abnormal_learning/memory/cond0.81128693
91MP0003172_abnormal_lysosome_physiology0.80628161
92MP0002064_seizures0.80441694
93MP0003890_abnormal_embryonic-extraembry0.79440793
94MP0001299_abnormal_eye_distance/0.79214759
95MP0009745_abnormal_behavioral_response0.79109701
96MP0001501_abnormal_sleep_pattern0.78526471
97MP0002210_abnormal_sex_determination0.77937241
98MP0005174_abnormal_tail_pigmentation0.77765320
99MP0003283_abnormal_digestive_organ0.77623884
100MP0001502_abnormal_circadian_rhythm0.75578509
101MP0000372_irregular_coat_pigmentation0.74436454
102MP0000749_muscle_degeneration0.72928376
103MP0002909_abnormal_adrenal_gland0.69762931
104MP0002837_dystrophic_cardiac_calcinosis0.69560333
105MP0002572_abnormal_emotion/affect_behav0.69491970
106MP0003634_abnormal_glial_cell0.68504340
107MP0003045_fibrosis0.68065740
108MP0008874_decreased_physiological_sensi0.67864203
109MP0000778_abnormal_nervous_system0.67787773
110MP0008872_abnormal_physiological_respon0.67634514
111MP0001440_abnormal_grooming_behavior0.66378614
112MP0000751_myopathy0.66364891
113MP0001984_abnormal_olfaction0.62813714
114MP0002229_neurodegeneration0.61913445
115MP0008961_abnormal_basal_metabolism0.61286934
116MP0003633_abnormal_nervous_system0.61252133
117MP0010234_abnormal_vibrissa_follicle0.60281981
118MP0003868_abnormal_feces_composition0.60220198
119MP0009840_abnormal_foam_cell0.60191147
120MP0002269_muscular_atrophy0.58942957
121MP0000569_abnormal_digit_pigmentation0.56339419
122MP0002066_abnormal_motor_capabilities/c0.56313847
123MP0004924_abnormal_behavior0.55544297
124MP0005386_behavior/neurological_phenoty0.55544297
125MP0004130_abnormal_muscle_cell0.51953950
126MP0003631_nervous_system_phenotype0.51487123
127MP0003300_gastrointestinal_ulcer0.50105824
128MP0000579_abnormal_nail_morphology0.49905032
129MP0008775_abnormal_heart_ventricle0.49836101
130MP0001727_abnormal_embryo_implantation0.49722324
131MP0002752_abnormal_somatic_nervous0.49311984
132MP0000920_abnormal_myelination0.45854277
133MP0003806_abnormal_nucleotide_metabolis0.44808039
134MP0001756_abnormal_urination0.43440496
135MP0005165_increased_susceptibility_to0.43234792
136MP0004484_altered_response_of0.42411463
137MP0004036_abnormal_muscle_relaxation0.40856009
138MP0008569_lethality_at_weaning0.35947940
139MP0005623_abnormal_meninges_morphology0.35796487
140MP0003879_abnormal_hair_cell0.34960732
141MP0010352_gastrointestinal_tract_polyps0.33997220
142MP0004145_abnormal_muscle_electrophysio0.33712829
143MP0003632_abnormal_nervous_system0.33503230
144MP0004142_abnormal_muscle_tone0.33332475
145MP0002557_abnormal_social/conspecific_i0.33258509
146MP0001664_abnormal_digestion0.32468549
147MP0002972_abnormal_cardiac_muscle0.30169389
148MP0002160_abnormal_reproductive_system0.29993293
149MP0004233_abnormal_muscle_weight0.28999826
150MP0000639_abnormal_adrenal_gland0.28937975
151MP0000759_abnormal_skeletal_muscle0.28173816
152MP0005464_abnormal_platelet_physiology0.27903126
153MP0005647_abnormal_sex_gland0.27325757
154MP0004883_abnormal_blood_vessel0.26585784
155MP0000681_abnormal_thyroid_gland0.26052000
156MP0003698_abnormal_male_reproductive0.25917306

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)8.51738574
2Termporal pattern (HP:0011008)6.01935370
3Insidious onset (HP:0003587)6.01935370
4Dysautonomia (HP:0002459)5.81228365
5Abnormality of pain sensation (HP:0010832)5.44442189
6Impaired pain sensation (HP:0007328)5.44442189
7Pheochromocytoma (HP:0002666)5.39516462
8Segmental peripheral demyelination/remyelination (HP:0003481)5.27856107
9Neuroendocrine neoplasm (HP:0100634)4.90184988
10Action tremor (HP:0002345)4.68743591
11Hammertoe (HP:0001765)4.44890085
12Myokymia (HP:0002411)4.32544125
13Foot dorsiflexor weakness (HP:0009027)4.01353758
14Steppage gait (HP:0003376)3.98180329
15Ankle clonus (HP:0011448)3.87480147
16Hyporeflexia of lower limbs (HP:0002600)3.86693414
17Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.86640417
18Hypercortisolism (HP:0001578)3.72639337
19Distal arthrogryposis (HP:0005684)3.69824198
20Nephronophthisis (HP:0000090)3.68296886
21Pancreatic cysts (HP:0001737)3.59442535
22Abnormality of the foot musculature (HP:0001436)3.57593866
23Distal sensory impairment (HP:0002936)3.55277674
24Onion bulb formation (HP:0003383)3.51960138
25Bony spicule pigmentary retinopathy (HP:0007737)3.50315078
26Thoracolumbar scoliosis (HP:0002944)3.50241280
27Failure to thrive in infancy (HP:0001531)3.50012206
28Supranuclear gaze palsy (HP:0000605)3.49662573
29Limb dystonia (HP:0002451)3.43616512
30Molar tooth sign on MRI (HP:0002419)3.40288698
31Abnormality of midbrain morphology (HP:0002418)3.40288698
32Pancreatic fibrosis (HP:0100732)3.27382306
33Abnormal autonomic nervous system physiology (HP:0012332)3.23079330
34Urinary urgency (HP:0000012)3.22651608
35Abnormality of the corticospinal tract (HP:0002492)3.19657306
36Decreased motor nerve conduction velocity (HP:0003431)3.17983078
37Abnormality of the renal medulla (HP:0100957)3.16836336
38Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.14359440
39Facial shape deformation (HP:0011334)3.14342983
40Potter facies (HP:0002009)3.14342983
41Hypoplasia of the brainstem (HP:0002365)3.10384197
42Aplasia/Hypoplasia of the brainstem (HP:0007362)3.10384197
43Hyperventilation (HP:0002883)3.10169014
44True hermaphroditism (HP:0010459)3.08415477
45Attenuation of retinal blood vessels (HP:0007843)3.07485753
46Neoplasm of the peripheral nervous system (HP:0100007)3.06806395
47Thyroid carcinoma (HP:0002890)2.96301530
48Areflexia of lower limbs (HP:0002522)2.94962072
49Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.93318001
50Hypoventilation (HP:0002791)2.90311982
51Abnormality of the vocal cords (HP:0008777)2.90033962
52Medial flaring of the eyebrow (HP:0010747)2.90007986
53Chronic hepatic failure (HP:0100626)2.84722975
54Focal seizures (HP:0007359)2.84212655
55Optic nerve hypoplasia (HP:0000609)2.83561354
56Overlapping toe (HP:0001845)2.83271797
57Pendular nystagmus (HP:0012043)2.82091307
58Submucous cleft hard palate (HP:0000176)2.79395234
59Impaired proprioception (HP:0010831)2.78488823
60Gait imbalance (HP:0002141)2.72310569
61Lissencephaly (HP:0001339)2.71998797
62Congenital stationary night blindness (HP:0007642)2.71920141
63Hand muscle atrophy (HP:0009130)2.71458181
64Spastic gait (HP:0002064)2.68424118
65Myotonia (HP:0002486)2.67594650
66Abnormal respiratory epithelium morphology (HP:0012253)2.65134837
67Abnormal respiratory motile cilium morphology (HP:0005938)2.65134837
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.63766067
69Cerebral hemorrhage (HP:0001342)2.60815110
70Abnormality of the lower motor neuron (HP:0002366)2.58977321
71Chin dimple (HP:0010751)2.58388859
72Absent/shortened dynein arms (HP:0200106)2.57458746
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.57458746
74Pachygyria (HP:0001302)2.56477222
75Abnormal rod and cone electroretinograms (HP:0008323)2.56317239
76Autoamputation (HP:0001218)2.53843912
77Bowel diverticulosis (HP:0005222)2.50455677
78Abnormality of the renal cortex (HP:0011035)2.49155248
79Urinary bladder sphincter dysfunction (HP:0002839)2.46308291
80Congenital primary aphakia (HP:0007707)2.45867225
81Distal lower limb muscle weakness (HP:0009053)2.44499695
82Atonic seizures (HP:0010819)2.42386959
83Congenital sensorineural hearing impairment (HP:0008527)2.40601655
84Abolished electroretinogram (ERG) (HP:0000550)2.39526691
85Focal motor seizures (HP:0011153)2.38718996
86Polyphagia (HP:0002591)2.34976976
87Insomnia (HP:0100785)2.34649807
88Adducted thumb (HP:0001181)2.33424362
89Upper limb muscle weakness (HP:0003484)2.31599482
90Abnormality of the parathyroid morphology (HP:0011766)2.31208354
91Sclerocornea (HP:0000647)2.30967290
92Lower limb muscle weakness (HP:0007340)2.29832677
93Increased CSF protein (HP:0002922)2.28827516
94Intestinal atresia (HP:0011100)2.26255095
95Clonus (HP:0002169)2.25880788
96Upper limb amyotrophy (HP:0009129)2.25778443
97Distal upper limb amyotrophy (HP:0007149)2.25778443
98Type II lissencephaly (HP:0007260)2.25526218
99Abnormality of calcium-phosphate metabolism (HP:0100530)2.24765004
100Hypothermia (HP:0002045)2.24355045
101Genital tract atresia (HP:0001827)2.22369035
102Optic disc pallor (HP:0000543)2.22328451
103Nephrogenic diabetes insipidus (HP:0009806)2.21973874
104Anencephaly (HP:0002323)2.20934834
105Chorioretinal atrophy (HP:0000533)2.20832604
106Vaginal atresia (HP:0000148)2.20583824
107Progressive cerebellar ataxia (HP:0002073)2.19999512
108Decreased central vision (HP:0007663)2.17469463
109Paraplegia (HP:0010550)2.16096379
110Postural tremor (HP:0002174)2.15994319
111Amblyopia (HP:0000646)2.14645357
112Mask-like facies (HP:0000298)2.14348705
113Abnormal ciliary motility (HP:0012262)2.14044733
114Acute necrotizing encephalopathy (HP:0006965)2.14017214
115Anosmia (HP:0000458)2.13232275
116Cystic liver disease (HP:0006706)2.12770575
117Bradycardia (HP:0001662)2.12671681
118Broad-based gait (HP:0002136)2.12272639
119Tubular atrophy (HP:0000092)2.10714513
120Spastic paraplegia (HP:0001258)2.09587817
121Aqueductal stenosis (HP:0002410)2.09328076
122Drooling (HP:0002307)2.08956988
123Papilledema (HP:0001085)2.07307158
124Increased corneal curvature (HP:0100692)2.06305635
125Keratoconus (HP:0000563)2.06305635
126Peripheral demyelination (HP:0011096)2.06128030
127Vertebral arch anomaly (HP:0008438)2.05498110
128Abnormal respiratory motile cilium physiology (HP:0012261)2.03420995
129Ventricular fibrillation (HP:0001663)2.03227156
130Rib fusion (HP:0000902)2.03149369
131Pes cavus (HP:0001761)2.03037050
132Septo-optic dysplasia (HP:0100842)2.02600810
133Truncal ataxia (HP:0002078)2.01901627
134Agitation (HP:0000713)1.99342145
135Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98954807
136Abnormality of the musculature of the hand (HP:0001421)1.98269113
137Arthropathy (HP:0003040)1.98080968
138EMG: neuropathic changes (HP:0003445)1.96635721
139Abnormality of the aortic arch (HP:0012303)1.95539684
140Oligodactyly (hands) (HP:0001180)1.94779643
141Absent phalangeal crease (HP:0006109)1.94756469
142Inability to walk (HP:0002540)1.93825870
143Neonatal onset (HP:0003623)1.93737376
144Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92010112
145Peripheral hypomyelination (HP:0007182)1.91769980
146Poor coordination (HP:0002370)1.91580068
147Polydipsia (HP:0001959)1.90985102
148Abnormal drinking behavior (HP:0030082)1.90985102
149Anterior segment dysgenesis (HP:0007700)1.90715744
150Hyperparathyroidism (HP:0000843)1.90640672
151Abnormality of the labia minora (HP:0012880)1.88769865
152Severe visual impairment (HP:0001141)1.87834557
153Rapidly progressive (HP:0003678)1.87432301
154Growth hormone deficiency (HP:0000824)1.86970466
155Abnormality of magnesium homeostasis (HP:0004921)1.86534147
156Bile duct proliferation (HP:0001408)1.86433607
157Abnormal biliary tract physiology (HP:0012439)1.86433607
158Hypercalcemia (HP:0003072)1.86347481
159Optic nerve coloboma (HP:0000588)1.86029032
160Postaxial foot polydactyly (HP:0001830)1.85906025
161Excessive salivation (HP:0003781)1.83891524
162Acute encephalopathy (HP:0006846)1.83476635
163Tubulointerstitial nephritis (HP:0001970)1.83453876
164Concave nail (HP:0001598)1.82439245
165Abnormality of macular pigmentation (HP:0008002)1.82007969
166Hyperglycinemia (HP:0002154)1.81919471
167Congenital hepatic fibrosis (HP:0002612)1.81509090
168Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81068824
169Abnormality of alanine metabolism (HP:0010916)1.81068824
170Hyperalaninemia (HP:0003348)1.81068824
171Renal dysplasia (HP:0000110)1.80537113
172Decreased muscle mass (HP:0003199)1.80150311
173Specific learning disability (HP:0001328)1.80086490
174Type 2 muscle fiber atrophy (HP:0003554)1.79071005
175Postaxial hand polydactyly (HP:0001162)1.78169812
176Down-sloping shoulders (HP:0200021)1.77880887
177Patellar aplasia (HP:0006443)1.77571497
178Renal cortical cysts (HP:0000803)1.76281285
179Morphological abnormality of the pyramidal tract (HP:0002062)1.76005583
180Cerebellar dysplasia (HP:0007033)1.75824169
181Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.75093717
182Hypomagnesemia (HP:0002917)1.73963255
183Retinal dysplasia (HP:0007973)1.73630888
184Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72955643
185Torticollis (HP:0000473)1.72380953
186Abnormal mitochondria in muscle tissue (HP:0008316)1.72379093
187Progressive macrocephaly (HP:0004481)1.72318612
188Anophthalmia (HP:0000528)1.72254467
189Neoplasm of the thyroid gland (HP:0100031)1.69404136
190Knee flexion contracture (HP:0006380)1.69232457
191Hyperacusis (HP:0010780)1.69007333
192Febrile seizures (HP:0002373)1.67691063
193Cortical dysplasia (HP:0002539)1.67092391

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.32592773
2NTRK14.07537195
3MAP3K93.77216239
4RIPK43.66167092
5KSR23.48054639
6MAP4K23.33114207
7LMTK23.23900525
8NTRK33.12540252
9PNCK3.10544369
10MAPKAPK32.89894645
11MINK12.87368993
12LIMK12.86833184
13RET2.80233436
14MARK32.58581931
15WNK32.51159471
16MAP3K22.43664398
17LATS22.43453261
18ADRBK22.40344333
19INSRR2.40324743
20CAMKK22.22185398
21MAPK152.17594435
22MATK2.09907608
23PLK42.09543968
24EPHA32.06594275
25PAK61.90906703
26GRK51.89484779
27BMPR1B1.88134649
28NTRK21.70168056
29PRKD31.68321772
30PINK11.62549833
31ARAF1.54477176
32TAF11.52995901
33CAMKK11.48729118
34BCR1.47520115
35RPS6KA21.43905265
36GRK11.39689240
37DAPK21.37214663
38PLK21.35509144
39MAP2K11.33399276
40PDK31.32188854
41PDK41.32188854
42NEK11.32181607
43MAP3K121.32049343
44ZAK1.31693809
45PKN21.26488616
46PHKG11.25542179
47PHKG21.25542179
48FER1.24783106
49EPHB11.23654319
50SCYL21.21979216
51TESK11.20515461
52DYRK31.18334286
53TRIM281.16056789
54CAMK1D1.15967815
55NUAK11.14802003
56CDK141.12128800
57CSNK1G31.10109838
58MAP2K41.04316092
59DYRK1B1.03789829
60VRK11.03370725
61CSNK1G11.02915960
62MAP3K11.02897320
63TRIB31.01342503
64MAPKAPK50.98795704
65PTK20.97614725
66CSNK1A1L0.94884135
67MAP3K40.94661824
68TYRO30.93557092
69CDK50.92295086
70SIK20.91435630
71DDR20.90270912
72FGFR40.88774857
73PRKG20.88096291
74BCKDK0.87291095
75CAMK1G0.85950451
76OXSR10.83371180
77FGFR30.83018110
78TSSK60.82215839
79PDK10.80664841
80MAP2K20.79948291
81RPS6KB20.78027102
82UHMK10.77717196
83SGK2230.77637640
84SGK4940.77637640
85EPHA40.75320384
86MAPK130.73362219
87DYRK20.71386780
88WNK10.69618592
89MARK10.68954551
90EEF2K0.68386562
91TLK10.68032340
92EPHB20.67925115
93DYRK1A0.64810766
94PAK30.63019899
95FRK0.62822471
96TESK20.62807396
97PDPK10.61779364
98PIM20.61504022
99TIE10.59655632
100BLK0.59536234
101VRK20.59391561
102CAMK2A0.58350801
103TNIK0.58295984
104PRKCZ0.57377873
105FLT30.56376434
106LRRK20.56258867
107SRPK10.55838319
108PKN10.55261982
109TGFBR10.52766888
110WNK40.52231842
111CAMK10.50320417
112PRKG10.49773234
113CDK180.48509024
114PTK2B0.48250046
115PRKACA0.48198330
116PRKACB0.47320837
117STK390.47286389
118FGFR20.46844629
119CDK150.46499623
120CSNK1E0.46458844
121PRKCG0.45469244
122BRD40.45398147
123ALK0.44697137
124NME10.44373224
125ERBB30.44130984
126CDK80.43310933
127MAP2K70.41539826
128ACVR1B0.40694858
129PRKCE0.40430208
130MAPK40.40255072
131STK38L0.39796883
132HIPK20.39766234
133ADRBK10.39732529
134ICK0.39480717
135AURKA0.38593676
136YES10.37475923
137ERN10.37003860
138CSNK1A10.36271610
139CDK11A0.36117834
140SRC0.35957550
141ERBB20.35192579
142CSNK1G20.33953661
143SGK20.33869123
144CDC42BPA0.33594345
145STK110.32040536
146WEE10.31313154
147KSR10.31247989
148GRK70.31078892
149MAP3K110.29794245
150SGK30.29515844
151GSK3B0.29437294
152RPS6KA50.29288241
153MKNK10.29278098
154CSNK1D0.29042466
155MUSK0.28617480
156DAPK10.28283857
157RAF10.27922992
158MAPK100.27688743
159SYK0.26215210
160PDGFRA0.26098873
161PDK20.24592423
162PRKCD0.24234875
163RPS6KB10.22454282

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.86775113
2Nicotine addiction_Homo sapiens_hsa050333.39257556
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.23757865
4Synaptic vesicle cycle_Homo sapiens_hsa047213.19898323
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.18233351
6Renin-angiotensin system_Homo sapiens_hsa046143.00740491
7Oxidative phosphorylation_Homo sapiens_hsa001902.98804802
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.68335238
9Parkinsons disease_Homo sapiens_hsa050122.66093408
10Phototransduction_Homo sapiens_hsa047442.47301151
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.32134853
12Butanoate metabolism_Homo sapiens_hsa006502.29851513
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21550407
14Thyroid cancer_Homo sapiens_hsa052162.17824813
15* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11062040
16Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.09851342
17Steroid biosynthesis_Homo sapiens_hsa001002.02583298
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98162057
19Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.91389041
20Linoleic acid metabolism_Homo sapiens_hsa005911.84242587
21Huntingtons disease_Homo sapiens_hsa050161.78259789
22Basal transcription factors_Homo sapiens_hsa030221.76802440
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76579022
24Cocaine addiction_Homo sapiens_hsa050301.74686497
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.74062003
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71230764
27Alzheimers disease_Homo sapiens_hsa050101.69632873
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.66729444
29Insulin secretion_Homo sapiens_hsa049111.62609820
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58987527
31Olfactory transduction_Homo sapiens_hsa047401.53072672
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.50479200
33Dopaminergic synapse_Homo sapiens_hsa047281.50435820
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49794777
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46270732
36Glioma_Homo sapiens_hsa052141.44345324
37VEGF signaling pathway_Homo sapiens_hsa043701.43923564
38Nitrogen metabolism_Homo sapiens_hsa009101.37368424
39Ether lipid metabolism_Homo sapiens_hsa005651.36709878
40Insulin signaling pathway_Homo sapiens_hsa049101.35739242
41RNA polymerase_Homo sapiens_hsa030201.35473315
42Propanoate metabolism_Homo sapiens_hsa006401.35289762
43Dorso-ventral axis formation_Homo sapiens_hsa043201.34439729
44Glycerolipid metabolism_Homo sapiens_hsa005611.33091472
45Protein export_Homo sapiens_hsa030601.32955157
46Long-term potentiation_Homo sapiens_hsa047201.32193089
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.31451646
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28458334
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27576722
50Oocyte meiosis_Homo sapiens_hsa041141.22627269
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19916031
52Cholinergic synapse_Homo sapiens_hsa047251.18570212
53Gap junction_Homo sapiens_hsa045401.16779023
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16317616
55Fatty acid biosynthesis_Homo sapiens_hsa000611.16031895
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14415160
57mTOR signaling pathway_Homo sapiens_hsa041501.12331423
58Type II diabetes mellitus_Homo sapiens_hsa049301.10363895
59Phospholipase D signaling pathway_Homo sapiens_hsa040721.10013867
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08731485
61Caffeine metabolism_Homo sapiens_hsa002321.08305298
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05998532
63Hedgehog signaling pathway_Homo sapiens_hsa043401.04863833
64Cyanoamino acid metabolism_Homo sapiens_hsa004601.04030273
65Peroxisome_Homo sapiens_hsa041461.03892813
66Salivary secretion_Homo sapiens_hsa049701.03741896
67Primary bile acid biosynthesis_Homo sapiens_hsa001201.03534671
68Estrogen signaling pathway_Homo sapiens_hsa049151.02033569
69Salmonella infection_Homo sapiens_hsa051321.00615438
70GnRH signaling pathway_Homo sapiens_hsa049121.00072675
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00052851
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.99382331
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99147894
74Endometrial cancer_Homo sapiens_hsa052130.98561870
75Vibrio cholerae infection_Homo sapiens_hsa051100.97989389
76Ribosome_Homo sapiens_hsa030100.97221683
77ErbB signaling pathway_Homo sapiens_hsa040120.97012367
78Endocytosis_Homo sapiens_hsa041440.96739145
79Tryptophan metabolism_Homo sapiens_hsa003800.96457795
80Selenocompound metabolism_Homo sapiens_hsa004500.95516873
81Phagosome_Homo sapiens_hsa041450.95346419
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94767340
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94270428
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.91601793
85Glutamatergic synapse_Homo sapiens_hsa047240.91152543
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87405192
87Choline metabolism in cancer_Homo sapiens_hsa052310.87090276
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.86910801
89Fanconi anemia pathway_Homo sapiens_hsa034600.86888899
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86420354
91RNA degradation_Homo sapiens_hsa030180.86027882
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85786398
93Circadian entrainment_Homo sapiens_hsa047130.85530150
94Chemical carcinogenesis_Homo sapiens_hsa052040.85074547
95Prolactin signaling pathway_Homo sapiens_hsa049170.83319577
96Basal cell carcinoma_Homo sapiens_hsa052170.83265174
97Collecting duct acid secretion_Homo sapiens_hsa049660.82751759
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80113808
99Regulation of autophagy_Homo sapiens_hsa041400.79016213
100Cardiac muscle contraction_Homo sapiens_hsa042600.77885631
101Bile secretion_Homo sapiens_hsa049760.76877824
102Retinol metabolism_Homo sapiens_hsa008300.76063686
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75865494
104Pyruvate metabolism_Homo sapiens_hsa006200.75299692
105Thyroid hormone synthesis_Homo sapiens_hsa049180.73852057
106Gastric acid secretion_Homo sapiens_hsa049710.73338562
107Long-term depression_Homo sapiens_hsa047300.72432885
108Fat digestion and absorption_Homo sapiens_hsa049750.72074964
109Melanoma_Homo sapiens_hsa052180.70613082
110Pancreatic secretion_Homo sapiens_hsa049720.70496897
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66314599
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64748239
113* Calcium signaling pathway_Homo sapiens_hsa040200.64130484
114Melanogenesis_Homo sapiens_hsa049160.63781426
115* Taste transduction_Homo sapiens_hsa047420.63248870
116Oxytocin signaling pathway_Homo sapiens_hsa049210.62394940
117Serotonergic synapse_Homo sapiens_hsa047260.61840097
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61760217
119Glucagon signaling pathway_Homo sapiens_hsa049220.61588094
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61329597
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61068897
122ABC transporters_Homo sapiens_hsa020100.59764441
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58716533
124Viral myocarditis_Homo sapiens_hsa054160.58497211
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58245900
126Non-small cell lung cancer_Homo sapiens_hsa052230.58197834
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57942873
128Metabolic pathways_Homo sapiens_hsa011000.55416349
129Insulin resistance_Homo sapiens_hsa049310.55007711
130Shigellosis_Homo sapiens_hsa051310.54809309
131Alcoholism_Homo sapiens_hsa050340.54565114
132cAMP signaling pathway_Homo sapiens_hsa040240.54114455
133Hippo signaling pathway_Homo sapiens_hsa043900.53618090
134Rap1 signaling pathway_Homo sapiens_hsa040150.51735675
135Bladder cancer_Homo sapiens_hsa052190.50052147
136Purine metabolism_Homo sapiens_hsa002300.49497505
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49114784
138Axon guidance_Homo sapiens_hsa043600.48585418
139GABAergic synapse_Homo sapiens_hsa047270.48359694
140Mineral absorption_Homo sapiens_hsa049780.46386347
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45576451
142Morphine addiction_Homo sapiens_hsa050320.44884850
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44858017
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44471074
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42151549
146AMPK signaling pathway_Homo sapiens_hsa041520.41930363
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.41744928
148Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39917519
149Amphetamine addiction_Homo sapiens_hsa050310.39639795
150RNA transport_Homo sapiens_hsa030130.39531296
151Fatty acid metabolism_Homo sapiens_hsa012120.39411397
152Amoebiasis_Homo sapiens_hsa051460.39283343
153Ovarian steroidogenesis_Homo sapiens_hsa049130.38766262
154MAPK signaling pathway_Homo sapiens_hsa040100.37517944
155cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36665685
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36637687
157Chronic myeloid leukemia_Homo sapiens_hsa052200.36188395
158Arachidonic acid metabolism_Homo sapiens_hsa005900.36143092
159HIF-1 signaling pathway_Homo sapiens_hsa040660.35462071
160AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35375290
161Protein digestion and absorption_Homo sapiens_hsa049740.34841354
162Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31930079
163Carbon metabolism_Homo sapiens_hsa012000.31577313
164Wnt signaling pathway_Homo sapiens_hsa043100.31168922
165Homologous recombination_Homo sapiens_hsa034400.28346529
166Tyrosine metabolism_Homo sapiens_hsa003500.27238032
167beta-Alanine metabolism_Homo sapiens_hsa004100.26826596
168TGF-beta signaling pathway_Homo sapiens_hsa043500.26332704

Most similar genes based on co-expression Upload to Enrichr

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