P2RX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)4.39499692
2modulation by symbiont of host defense response (GO:0052031)4.39499692
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.39499692
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.39499692
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.39499692
6modulation by symbiont of host immune response (GO:0052553)4.39499692
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.35817475
8neutrophil activation involved in immune response (GO:0002283)4.25916979
9negative regulation of interleukin-12 production (GO:0032695)4.08817026
10kynurenine metabolic process (GO:0070189)3.75753869
11positive regulation of antigen processing and presentation (GO:0002579)3.75518153
12response to peptidoglycan (GO:0032494)3.70651942
13regulation of dendritic cell antigen processing and presentation (GO:0002604)3.67182284
14regulation of interferon-beta biosynthetic process (GO:0045357)3.66712477
15positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.54557865
16respiratory burst (GO:0045730)3.50808035
17regulation of antigen processing and presentation (GO:0002577)3.48471326
18positive regulation of interferon-alpha production (GO:0032727)3.46486770
19positive regulation of defense response to virus by host (GO:0002230)3.44708450
20positive regulation of cellular amide metabolic process (GO:0034250)3.41202390
21macrophage activation involved in immune response (GO:0002281)3.38422898
22positive regulation of heat generation (GO:0031652)3.38356688
23regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.30941507
24positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.30631932
25regulation of vitamin D biosynthetic process (GO:0060556)3.30081355
26regulation of chronic inflammatory response (GO:0002676)3.29639039
27regulation of T-helper 1 cell differentiation (GO:0045625)3.29315140
28regulation of interferon-alpha production (GO:0032647)3.26364202
29regulation of cytokine secretion involved in immune response (GO:0002739)3.26256366
30regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.22275985
31cellular biogenic amine catabolic process (GO:0042402)3.19664826
32amine catabolic process (GO:0009310)3.19664826
33microglial cell activation (GO:0001774)3.19222127
34detection of molecule of bacterial origin (GO:0032490)3.16784104
35indolalkylamine metabolic process (GO:0006586)3.15950323
36negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.15615201
37superoxide anion generation (GO:0042554)3.10269479
38hydrogen peroxide biosynthetic process (GO:0050665)3.06056144
39positive regulation of NF-kappaB import into nucleus (GO:0042346)3.02484196
40interferon-gamma-mediated signaling pathway (GO:0060333)2.99417213
41amyloid precursor protein catabolic process (GO:0042987)2.99315911
42neutrophil activation (GO:0042119)2.99017843
43oligosaccharide catabolic process (GO:0009313)2.98844422
44production of molecular mediator involved in inflammatory response (GO:0002532)2.95479333
45granulocyte activation (GO:0036230)2.95150354
46positive regulation of chemokine biosynthetic process (GO:0045080)2.93125080
47immunoglobulin mediated immune response (GO:0016064)2.92203617
48eosinophil chemotaxis (GO:0048245)2.92050811
49macrophage activation (GO:0042116)2.91755332
50regulation of inflammatory response to antigenic stimulus (GO:0002861)2.91717765
51response to protozoan (GO:0001562)2.89905916
52negative regulation of interleukin-1 beta production (GO:0032691)2.88891752
53response to host immune response (GO:0052572)2.87515290
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.87515290
55positive regulation of monocyte chemotaxis (GO:0090026)2.86189153
56regulation of mononuclear cell migration (GO:0071675)2.85415079
57cellular response to exogenous dsRNA (GO:0071360)2.84863178
58regulation of interleukin-12 production (GO:0032655)2.83020012
59positive regulation of gamma-delta T cell activation (GO:0046645)2.82996038
60defense response to protozoan (GO:0042832)2.81003533
61negative regulation of nitric oxide biosynthetic process (GO:0045019)2.80553855
62regulation of fever generation (GO:0031620)2.78237763
63regulation of heat generation (GO:0031650)2.78178480
64reactive oxygen species biosynthetic process (GO:1903409)2.76286521
65regulation of vitamin metabolic process (GO:0030656)2.75300065
66complement activation, alternative pathway (GO:0006957)2.74048113
67cellular response to type I interferon (GO:0071357)2.73724767
68type I interferon signaling pathway (GO:0060337)2.73724767
69pinocytosis (GO:0006907)2.73287521
70T-helper 1 type immune response (GO:0042088)2.73036057
71myeloid cell activation involved in immune response (GO:0002275)2.72906234
72monocyte chemotaxis (GO:0002548)2.72229342
73regulation of chemokine biosynthetic process (GO:0045073)2.71848406
74response to type I interferon (GO:0034340)2.71422913
75response to muramyl dipeptide (GO:0032495)2.70519641
76negative regulation of cytokine production involved in immune response (GO:0002719)2.67868442
77positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.67435273
78positive regulation of T-helper 1 type immune response (GO:0002827)2.66711750
79DNA deamination (GO:0045006)2.65819001
80antigen processing and presentation of endogenous antigen (GO:0019883)2.65671519
81positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.65430585
82positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.65401846
83glycosphingolipid catabolic process (GO:0046479)2.64049848
84negative regulation of interleukin-1 production (GO:0032692)2.62607224
85detection of other organism (GO:0098543)2.61442641
86positive regulation of mast cell activation (GO:0033005)2.61410309
87eosinophil migration (GO:0072677)2.60490286
88positive regulation of interleukin-12 production (GO:0032735)2.60284365
89lipopolysaccharide-mediated signaling pathway (GO:0031663)2.59356826
90B cell mediated immunity (GO:0019724)2.59186625
91regulation of hypersensitivity (GO:0002883)2.58428116
92regulation of mast cell degranulation (GO:0043304)2.58120671
93germinal center formation (GO:0002467)2.57686679
94peptidyl-glutamic acid carboxylation (GO:0017187)2.57464710
95protein carboxylation (GO:0018214)2.57464710
96detection of external biotic stimulus (GO:0098581)2.56370002
97negative regulation of lipid storage (GO:0010888)2.55413407
98positive regulation of natural killer cell activation (GO:0032816)2.54164453
99regulation of defense response to virus by host (GO:0050691)2.54044562
100regulation of mast cell activation (GO:0033003)2.54019354
101regulation of interleukin-8 biosynthetic process (GO:0045414)2.53855374
102positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.52944492
103positive regulation of toll-like receptor signaling pathway (GO:0034123)2.52879644
104positive regulation of T cell migration (GO:2000406)2.52634756
105interferon-gamma secretion (GO:0072643)2.52530718
106regulation of T-helper 1 type immune response (GO:0002825)2.52365158
107positive regulation of T-helper cell differentiation (GO:0045624)2.52344514
108tryptophan metabolic process (GO:0006568)2.52107034
109NIK/NF-kappaB signaling (GO:0038061)2.51315669
110phospholipid efflux (GO:0033700)2.50900112
111positive regulation of interleukin-17 production (GO:0032740)2.50685631
112positive regulation of interferon-beta production (GO:0032728)2.50488886
113negative regulation of mast cell activation (GO:0033004)2.50359181
114triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.49743826
115positive regulation of type 2 immune response (GO:0002830)2.49439761
116positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48737028
117regulation of interleukin-1 beta secretion (GO:0050706)2.48143484
118cellular response to thyroid hormone stimulus (GO:0097067)2.47817454
119regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.47640391
120cellular response to ethanol (GO:0071361)2.47288666
121response to interferon-gamma (GO:0034341)2.45755840
122glycolipid catabolic process (GO:0019377)2.45624733
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.45476403
124L-phenylalanine catabolic process (GO:0006559)2.45476403
125regulation of activation of Janus kinase activity (GO:0010533)2.45185272
126regulation of gamma-delta T cell activation (GO:0046643)2.45041227
127intracellular pH reduction (GO:0051452)2.43609129
128cellular response to interferon-gamma (GO:0071346)2.43535179
129positive regulation of lymphocyte migration (GO:2000403)2.43416852
130aromatic amino acid family catabolic process (GO:0009074)2.43287970
131positive regulation of mast cell activation involved in immune response (GO:0033008)2.43035297
132positive regulation of mast cell degranulation (GO:0043306)2.43035297
133platelet dense granule organization (GO:0060155)2.42111490
134response to interferon-beta (GO:0035456)2.42048488
135response to host (GO:0075136)2.41825196
136response to host defenses (GO:0052200)2.41825196
137response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.41825196
138regulation of cholesterol esterification (GO:0010872)2.41481679
139positive regulation of B cell differentiation (GO:0045579)2.41403577
140amyloid precursor protein metabolic process (GO:0042982)2.41027826
141indole-containing compound catabolic process (GO:0042436)2.39598526
142indolalkylamine catabolic process (GO:0046218)2.39598526
143tryptophan catabolic process (GO:0006569)2.39598526
144regulation of mast cell activation involved in immune response (GO:0033006)2.38719319
145response to thyroid hormone (GO:0097066)2.37640498
146regulation of T cell migration (GO:2000404)2.37383674
147positive regulation of coagulation (GO:0050820)2.36832584
148cholesterol efflux (GO:0033344)2.36268622
149plasma lipoprotein particle clearance (GO:0034381)2.34896991
150detection of biotic stimulus (GO:0009595)2.34782982
151positive regulation of natural killer cell differentiation (GO:0032825)2.34613821
152antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.33094265
153antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.33094265
154regulation of B cell receptor signaling pathway (GO:0050855)2.32381689
155positive regulation of interleukin-1 beta secretion (GO:0050718)2.31621060
156NAD biosynthetic process (GO:0009435)2.31430860
157response to interferon-alpha (GO:0035455)2.31286195
158myeloid leukocyte activation (GO:0002274)2.30718107
159ceramide catabolic process (GO:0046514)2.30058953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.48837993
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.17929988
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.02872160
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.68830653
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.57770136
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.41845644
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.33272507
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.27389597
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.10323120
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.94293052
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.85388182
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78490608
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.52990808
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.43803209
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37863568
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36898185
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36459710
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.35491934
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.21550627
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.97544942
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88223519
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86588323
23GATA1_22025678_ChIP-Seq_K562_Human1.84254094
24* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81185390
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80763337
26ZNF274_21170338_ChIP-Seq_K562_Hela1.80258453
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78801689
28* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77166558
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75307876
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74379779
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69447412
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.65145254
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62497491
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52498617
35SCL_19346495_ChIP-Seq_HPC-7_Human1.51080305
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50729820
37VDR_24787735_ChIP-Seq_THP-1_Human1.50656696
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45499500
39SPI1_23547873_ChIP-Seq_NB4_Human1.43407684
40CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43242787
41PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42624330
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40672428
43STAT1_20625510_ChIP-Seq_HELA_Human1.38623642
44RUNX_20019798_ChIP-Seq_JUKART_Human1.37863478
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37792927
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37497484
47PU_27001747_Chip-Seq_BMDM_Mouse1.37231613
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.37018127
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34951924
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.32827248
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31682241
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27818922
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26286187
54GATA3_27048872_Chip-Seq_THYMUS_Human1.25821316
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25400935
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25350481
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22433446
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20143934
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18464222
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18464222
61SOX2_20726797_ChIP-Seq_SW620_Human1.17085668
62* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16232798
63VDR_22108803_ChIP-Seq_LS180_Human1.15347863
64* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14120160
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.13658988
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11427005
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09135381
68* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08398681
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08235455
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07456432
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06269493
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06183905
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05672866
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02405704
75ER_23166858_ChIP-Seq_MCF-7_Human1.01835829
76* RUNX1_22412390_ChIP-Seq_EML_Mouse1.01403957
77SPI1_23127762_ChIP-Seq_K562_Human1.00088122
78SMRT_27268052_Chip-Seq_Bcells_Human0.98841538
79BCL6_27268052_Chip-Seq_Bcells_Human0.97369017
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96962226
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96438420
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96085791
83EGR1_19032775_ChIP-ChIP_M12_Human0.96076287
84TAF2_19829295_ChIP-Seq_ESCs_Human0.95615457
85* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95096608
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94811097
87AR_20517297_ChIP-Seq_VCAP_Human0.93216273
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92748012
89GATA3_26560356_Chip-Seq_TH2_Human0.91970426
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91877698
91VDR_24763502_ChIP-Seq_THP-1_Human0.91765753
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91696382
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90931897
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89220415
95MYB_26560356_Chip-Seq_TH2_Human0.89188480
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.88225224
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87369795
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.87369795
99GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86245196
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86194450
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85939793
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85675318
103IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85420734
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85406293
105RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84949115
106BCOR_27268052_Chip-Seq_Bcells_Human0.83998739
107P300_27268052_Chip-Seq_Bcells_Human0.83506329
108NANOG_19829295_ChIP-Seq_ESCs_Human0.83125732
109SOX2_19829295_ChIP-Seq_ESCs_Human0.83125732
110GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.82828039
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82553177
112MYC_19829295_ChIP-Seq_ESCs_Human0.82521595
113NFE2_27457419_Chip-Seq_LIVER_Mouse0.82345677
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.82343126
115BCAT_22108803_ChIP-Seq_LS180_Human0.81899039
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81339823
117* GATA4_25053715_ChIP-Seq_YYC3_Human0.80579778
118RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79944025
119P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79815692
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.79433694
121MYB_26560356_Chip-Seq_TH1_Human0.78573241
122TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78048433
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77995397
124ERA_21632823_ChIP-Seq_H3396_Human0.77994167
125OCT4_20526341_ChIP-Seq_ESCs_Human0.77944481
126FLI1_27457419_Chip-Seq_LIVER_Mouse0.77940786
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77879800
128GATA1_19941826_ChIP-Seq_K562_Human0.77627111
129TP63_17297297_ChIP-ChIP_HaCaT_Human0.77518592
130PU1_27457419_Chip-Seq_LIVER_Mouse0.77258590
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.76923223
132CJUN_26792858_Chip-Seq_BT549_Human0.76415665
133SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75116751
134* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75021271
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.74492384
136PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73792659
137RUNX1_27457419_Chip-Seq_LIVER_Mouse0.73441473
138TRIM28_21343339_ChIP-Seq_HEK293_Human0.72954183
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.70144066
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.69950810
141HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69870405
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.69391932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.69671422
2MP0005058_abnormal_lysosome_morphology3.19479463
3MP0003436_decreased_susceptibility_to2.75161055
4MP0006082_CNS_inflammation2.73309927
5MP0002148_abnormal_hypersensitivity_rea2.72336179
6MP0009840_abnormal_foam_cell2.71035971
7MP0003724_increased_susceptibility_to2.67650617
8* MP0002419_abnormal_innate_immunity2.65495207
9MP0009785_altered_susceptibility_to2.63914637
10MP0003191_abnormal_cellular_cholesterol2.49905080
11MP0002139_abnormal_hepatobiliary_system2.39634711
12MP0002254_reproductive_system_inflammat2.39100890
13MP0005000_abnormal_immune_tolerance2.38947590
14MP0001790_abnormal_immune_system2.38782603
15MP0005387_immune_system_phenotype2.38782603
16MP0005025_abnormal_response_to2.37152095
17MP0000685_abnormal_immune_system2.19736295
18MP0005671_abnormal_response_to2.05078381
19MP0005360_urolithiasis2.04990122
20MP0005365_abnormal_bile_salt2.01680742
21MP0003195_calcinosis2.00275784
22* MP0002452_abnormal_antigen_presenting1.94570039
23MP0005464_abnormal_platelet_physiology1.91213704
24MP0009764_decreased_sensitivity_to1.90650368
25MP0002138_abnormal_hepatobiliary_system1.89496805
26MP0001800_abnormal_humoral_immune1.88536822
27MP0003806_abnormal_nucleotide_metabolis1.88169713
28MP0002723_abnormal_immune_serum1.85710589
29MP0003172_abnormal_lysosome_physiology1.85607319
30MP0005085_abnormal_gallbladder_physiolo1.81970857
31MP0003690_abnormal_glial_cell1.74057805
32MP0008469_abnormal_protein_level1.73595669
33MP0008875_abnormal_xenobiotic_pharmacok1.70592816
34MP0001533_abnormal_skeleton_physiology1.69443760
35MP0002277_abnormal_respiratory_mucosa1.62193942
36MP0001845_abnormal_inflammatory_respons1.58347504
37MP0005310_abnormal_salivary_gland1.58259333
38* MP0001819_abnormal_immune_cell1.54769405
39MP0005083_abnormal_biliary_tract1.53875223
40* MP0002420_abnormal_adaptive_immunity1.53456416
41MP0002405_respiratory_system_inflammati1.49233697
42MP0004782_abnormal_surfactant_physiolog1.43956674
43MP0004510_myositis1.42939107
44MP0010329_abnormal_lipoprotein_level1.40612044
45MP0010155_abnormal_intestine_physiology1.40045002
46MP0003303_peritoneal_inflammation1.38815958
47MP0000604_amyloidosis1.34776030
48MP0008438_abnormal_cutaneous_collagen1.33630620
49MP0002998_abnormal_bone_remodeling1.33127060
50MP0005451_abnormal_body_composition1.33040964
51MP0003186_abnormal_redox_activity1.32733670
52MP0004019_abnormal_vitamin_homeostasis1.32140465
53MP0004381_abnormal_hair_follicle1.28443896
54MP0009278_abnormal_bone_marrow1.27383450
55MP0001501_abnormal_sleep_pattern1.26340431
56MP0000343_altered_response_to1.24664803
57MP0003646_muscle_fatigue1.23805565
58MP0003252_abnormal_bile_duct1.21275918
59MP0001853_heart_inflammation1.20785532
60MP0004947_skin_inflammation1.19455825
61MP0000465_gastrointestinal_hemorrhage1.16964143
62MP0009763_increased_sensitivity_to1.15092504
63MP0001545_abnormal_hematopoietic_system1.13214294
64MP0005397_hematopoietic_system_phenotyp1.13214294
65MP0002166_altered_tumor_susceptibility1.12067791
66MP0003075_altered_response_to1.11955292
67MP0005174_abnormal_tail_pigmentation1.09284178
68MP0002837_dystrophic_cardiac_calcinosis1.08661000
69MP0006054_spinal_hemorrhage1.08626231
70MP0002132_abnormal_respiratory_system1.07807320
71MP0000609_abnormal_liver_physiology1.07362953
72MP0005332_abnormal_amino_acid1.07210170
73* MP0009643_abnormal_urine_homeostasis1.06234695
74MP0010386_abnormal_urinary_bladder1.05951486
75MP0000716_abnormal_immune_system1.05393759
76MP0008260_abnormal_autophagy1.04924436
77MP0001666_abnormal_nutrient_absorption1.04646893
78MP0002933_joint_inflammation1.04166209
79MP0001663_abnormal_digestive_system1.03298677
80MP0003300_gastrointestinal_ulcer1.02756886
81MP0003448_altered_tumor_morphology1.00401161
82MP0005164_abnormal_response_to0.99493282
83MP0009333_abnormal_splenocyte_physiolog0.96997968
84MP0004043_abnormal_pH_regulation0.96778349
85MP0002118_abnormal_lipid_homeostasis0.96234514
86MP0000858_altered_metastatic_potential0.95035044
87MP0005166_decreased_susceptibility_to0.93753852
88MP0002693_abnormal_pancreas_physiology0.93449713
89MP0002006_tumorigenesis0.92897479
90MP0000569_abnormal_digit_pigmentation0.92675183
91MP0003183_abnormal_peptide_metabolism0.92574008
92MP0001873_stomach_inflammation0.92496847
93MP0002332_abnormal_exercise_endurance0.92153415
94MP0002136_abnormal_kidney_physiology0.91013049
95MP0000920_abnormal_myelination0.89853581
96MP0005257_abnormal_intraocular_pressure0.87790419
97MP0001764_abnormal_homeostasis0.86927448
98MP0000689_abnormal_spleen_morphology0.86303424
99MP0005408_hypopigmentation0.85429827
100MP0002876_abnormal_thyroid_physiology0.85351481
101MP0008004_abnormal_stomach_pH0.84992005
102MP0005390_skeleton_phenotype0.84861300
103MP0001958_emphysema0.84307556
104MP0005319_abnormal_enzyme/_coenzyme0.84303319
105MP0000015_abnormal_ear_pigmentation0.83794789
106MP0003866_abnormal_defecation0.82756903
107MP0005584_abnormal_enzyme/coenzyme_acti0.82328064
108MP0001851_eye_inflammation0.79178315
109MP0002429_abnormal_blood_cell0.78907459
110MP0005167_abnormal_blood-brain_barrier0.77442358
111MP0000371_diluted_coat_color0.77372851
112MP0002295_abnormal_pulmonary_circulatio0.77033779
113MP0003656_abnormal_erythrocyte_physiolo0.76969617
114MP0003763_abnormal_thymus_physiology0.75902239
115MP0000372_irregular_coat_pigmentation0.75646045
116MP0002398_abnormal_bone_marrow0.74764955
117MP0002722_abnormal_immune_system0.72926369
118MP0005535_abnormal_body_temperature0.69355716
119MP0005410_abnormal_fertilization0.68726324
120MP0005647_abnormal_sex_gland0.68218667
121MP0009765_abnormal_xenobiotic_induced0.68201593
122MP0005084_abnormal_gallbladder_morpholo0.66981216
123MP0005379_endocrine/exocrine_gland_phen0.66692740
124MP0004147_increased_porphyrin_level0.66435430
125MP0001919_abnormal_reproductive_system0.66148913

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)5.60479954
2Systemic lupus erythematosus (HP:0002725)5.49766309
3Recurrent abscess formation (HP:0002722)5.32246398
4Recurrent bacterial skin infections (HP:0005406)4.99408203
5Eczematoid dermatitis (HP:0000976)4.89353516
6Recurrent gram-negative bacterial infections (HP:0005420)4.70938995
7Glomerulonephritis (HP:0000099)4.37555320
8Abnormality of macrophages (HP:0004311)4.32704516
9Complement deficiency (HP:0004431)3.95947316
10Increased cerebral lipofuscin (HP:0011813)3.72070160
11Joint hemorrhage (HP:0005261)3.69570775
12Increased neuronal autofluorescent lipopigment (HP:0002074)3.57594896
13Dysostosis multiplex (HP:0000943)3.45863053
14Abnormality of complement system (HP:0005339)3.44805629
15Recurrent skin infections (HP:0001581)3.43615868
16Axonal loss (HP:0003447)3.24712959
17Abnormality of glycolipid metabolism (HP:0010969)3.23776221
18Abnormality of liposaccharide metabolism (HP:0010968)3.23776221
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.23776221
20Gingivitis (HP:0000230)3.15477976
21Myocardial infarction (HP:0001658)3.07834494
22Prolonged partial thromboplastin time (HP:0003645)2.99325836
23Spontaneous hematomas (HP:0007420)2.97582006
24Elevated erythrocyte sedimentation rate (HP:0003565)2.87659783
25Nephritis (HP:0000123)2.83023374
26Mucopolysacchariduria (HP:0008155)2.81480187
27Urinary glycosaminoglycan excretion (HP:0003541)2.81480187
28Thick nail (HP:0001805)2.80990675
29Abnormality of polysaccharide metabolism (HP:0011012)2.79669239
30Abnormality of glycosaminoglycan metabolism (HP:0004371)2.79669239
31Abnormality of mucopolysaccharide metabolism (HP:0011020)2.79669239
32Myositis (HP:0100614)2.79234853
33Disinhibition (HP:0000734)2.77826424
34Gingival bleeding (HP:0000225)2.77442715
35Chronic obstructive pulmonary disease (HP:0006510)2.75350471
36Obstructive lung disease (HP:0006536)2.75350471
37Pustule (HP:0200039)2.73414349
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.73135026
39Recurrent fungal infections (HP:0002841)2.67438118
40Orchitis (HP:0100796)2.67390155
41Mediastinal lymphadenopathy (HP:0100721)2.64460062
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.62772817
43Petechiae (HP:0000967)2.62530727
44Xanthomatosis (HP:0000991)2.59580561
45Amyloidosis (HP:0011034)2.53560731
46Hepatosplenomegaly (HP:0001433)2.52589459
47Autoimmune hemolytic anemia (HP:0001890)2.51679449
48Retrobulbar optic neuritis (HP:0100654)2.51369003
49Optic neuritis (HP:0100653)2.51369003
50Loss of speech (HP:0002371)2.46923212
51Abnormality of T cell number (HP:0011839)2.46737404
52Hemoptysis (HP:0002105)2.44011993
53Purpura (HP:0000979)2.42872703
54Increased IgM level (HP:0003496)2.41935705
55Interstitial pulmonary disease (HP:0006530)2.41709577
56Mutism (HP:0002300)2.41547349
57Keratoconjunctivitis (HP:0001096)2.40427402
58Autoimmune thrombocytopenia (HP:0001973)2.40052228
59Periodontitis (HP:0000704)2.39351597
60Vasculitis (HP:0002633)2.37029385
61Intrahepatic cholestasis (HP:0001406)2.36808543
62Urticaria (HP:0001025)2.36299797
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.35881124
64Recurrent cutaneous fungal infections (HP:0011370)2.33986135
65Chronic mucocutaneous candidiasis (HP:0002728)2.33986135
66Keratoconjunctivitis sicca (HP:0001097)2.32844562
67Abnormality of the common coagulation pathway (HP:0010990)2.30851904
68Prolonged neonatal jaundice (HP:0006579)2.29441253
69Abolished electroretinogram (ERG) (HP:0000550)2.24141158
70Conjugated hyperbilirubinemia (HP:0002908)2.22298307
71Abnormality of B cell number (HP:0010975)2.21618459
72Increased serum ferritin (HP:0003281)2.21462933
73Recurrent pneumonia (HP:0006532)2.20527431
74Albinism (HP:0001022)2.18678289
75Mesangial abnormality (HP:0001966)2.18627308
76Pulmonary infiltrates (HP:0002113)2.17617344
77Epistaxis (HP:0000421)2.16569341
78Prostate neoplasm (HP:0100787)2.14826949
79Abnormality of transition element cation homeostasis (HP:0011030)2.14711313
80Hyperlipoproteinemia (HP:0010980)2.14527087
81Pathologic fracture (HP:0002756)2.13906099
82Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13671142
83Osteomyelitis (HP:0002754)2.13440481
84Menorrhagia (HP:0000132)2.13225362
85Stomach cancer (HP:0012126)2.12976689
86Prolonged bleeding time (HP:0003010)2.12198432
87Bone pain (HP:0002653)2.11425037
88T lymphocytopenia (HP:0005403)2.11127191
89Stomatitis (HP:0010280)2.08828245
90Congenital sensorineural hearing impairment (HP:0008527)2.07259106
91Abnormality of iron homeostasis (HP:0011031)2.06852572
92Polyneuropathy (HP:0001271)2.05027988
93Vascular calcification (HP:0004934)2.04511607
94Recurrent viral infections (HP:0004429)2.04405929
95Encephalitis (HP:0002383)2.02997333
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.01803718
97Congenital stationary night blindness (HP:0007642)2.01529402
98Abnormality of glutamine family amino acid metabolism (HP:0010902)2.01202973
99Pancreatic cysts (HP:0001737)1.99202078
100Abnormality of monocarboxylic acid metabolism (HP:0010996)1.98755121
101Hypercholesterolemia (HP:0003124)1.98343973
102Leukocytosis (HP:0001974)1.97828512
103Meningitis (HP:0001287)1.97062211
104Hematochezia (HP:0002573)1.96535414
105Fat malabsorption (HP:0002630)1.95938521
106Decreased circulating renin level (HP:0003351)1.94540081
107Abnormality of the vasculature of the conjunctiva (HP:0008054)1.94398235
108Basal ganglia calcification (HP:0002135)1.93285092
109Gangrene (HP:0100758)1.92563473
110Peripheral demyelination (HP:0011096)1.91725685
111Esophageal varix (HP:0002040)1.91054267
112Abnormality of the intrinsic pathway (HP:0010989)1.91050496
113Hydroxyprolinuria (HP:0003080)1.90695986
114Abnormality of proline metabolism (HP:0010907)1.90695986
115Deep venous thrombosis (HP:0002625)1.87905124
116Steatorrhea (HP:0002570)1.87615181
117Attenuation of retinal blood vessels (HP:0007843)1.86943631
118Progressive neurologic deterioration (HP:0002344)1.85615238
119Abnormality of the prostate (HP:0008775)1.85418202
120Abnormality of pyrimidine metabolism (HP:0004353)1.83785885
121Chronic diarrhea (HP:0002028)1.83208784
122Hypokinesia (HP:0002375)1.83086253
123Anorexia (HP:0002039)1.82516168
124Abnormality of the pleura (HP:0002103)1.82232091
125Abnormality of T cells (HP:0002843)1.81805246
126Metaphyseal irregularity (HP:0003025)1.80418744
127Inflammation of the large intestine (HP:0002037)1.80072381
128Retinal atrophy (HP:0001105)1.79985352
129IgG deficiency (HP:0004315)1.79599828
130Recurrent lower respiratory tract infections (HP:0002783)1.78748394
131Cardiovascular calcification (HP:0011915)1.78187900
132Parakeratosis (HP:0001036)1.78002983
133J-shaped sella turcica (HP:0002680)1.76645835
134Tetraparesis (HP:0002273)1.76607252
135Agitation (HP:0000713)1.76598378
136Eosinophilia (HP:0001880)1.74979044
137Pulmonary embolism (HP:0002204)1.74795639
138Nausea (HP:0002018)1.74217457
139Abnormality of the renal cortex (HP:0011035)1.74200600
140Abnormal drinking behavior (HP:0030082)1.72168314
141Polydipsia (HP:0001959)1.72168314
142Thyroiditis (HP:0100646)1.70126447
143Progressive visual loss (HP:0000529)1.69942525
144Agnosia (HP:0010524)1.69858827
145Abnormality of eosinophils (HP:0001879)1.69581186
146Hyperventilation (HP:0002883)1.68647872
147Inappropriate behavior (HP:0000719)1.68529919
148Malnutrition (HP:0004395)1.67814139
149Cardiomegaly (HP:0001640)1.67370404

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.34994262
2IRAK34.04081206
3MAP3K143.67829633
4ACVR1B3.62502937
5IRAK43.32693835
6TYK22.74617018
7TBK12.53666431
8KIT2.49226362
9TLK12.46230282
10TAOK32.32823286
11IKBKE2.28112367
12RIPK42.19181556
13INSRR2.13113037
14TGFBR22.10484564
15ERN12.08064390
16IKBKB2.03941223
17EPHB11.94327133
18TXK1.87412879
19MAP4K11.76398759
20JAK11.65520920
21CAMKK21.55956109
22MAP2K61.54474650
23JAK31.47981884
24TAOK21.46817274
25EPHA31.45019180
26MAP3K111.44171430
27FGFR41.43400598
28PIK3CG1.42835471
29TEC1.41679470
30ZAP701.38725998
31NEK91.37774488
32IRAK11.37696714
33PBK1.33958856
34GRK71.33611871
35MAP3K131.25600778
36DAPK21.25403966
37BTK1.25041268
38MAPKAPK51.23125640
39NLK1.21771634
40NME21.20227534
41MST41.19328166
42PIM21.18719616
43CSK1.18115647
44MAP4K21.11875461
45MAPKAPK31.10879591
46BMPR21.09668586
47LYN1.06993345
48PINK11.06713847
49CHUK1.04018031
50SYK1.03943454
51ADRBK21.01019770
52DDR21.00042820
53CSF1R0.97170532
54MST1R0.96405016
55HCK0.95405531
56NUAK10.94950589
57IRAK20.93330835
58TRPM70.92240923
59PIK3CA0.92087622
60BCKDK0.90242435
61LCK0.89715658
62TAOK10.88602761
63MAPK150.87942439
64JAK20.84132421
65ZAK0.83890114
66GRK10.83411407
67ABL20.82389525
68CDC42BPA0.81613463
69PKN10.81542079
70MATK0.78790471
71TGFBR10.76548351
72EIF2AK20.75709360
73STK160.75264932
74TIE10.72937179
75MAP3K30.72136814
76YES10.70742037
77MAP2K20.70607307
78GRK60.70486481
79FRK0.67702329
80MAP2K30.67275966
81ITK0.65276742
82ADRBK10.64215864
83OXSR10.62310932
84RPS6KA50.61727257
85PTK60.61303668
86PIM10.60112604
87CLK10.59992847
88KDR0.59606979
89SIK10.54082627
90ABL10.54017321
91MAP3K50.53976019
92FES0.53859772
93WNK30.51665502
94FGR0.50728280
95PRKCD0.50357019
96BMPR1B0.49552990
97PRKCQ0.48390965
98TNK20.47080985
99NEK60.46581387
100MAP3K10.45969599
101FGFR30.44895405
102FLT30.44805361
103MAPKAPK20.44161823
104WNK40.43216453
105PDK20.42931651
106FER0.42558347
107MUSK0.42539409
108CAMK1D0.42021178
109PDK10.40559111
110MYLK0.39592191
111STK390.39384282
112IGF1R0.39379613
113AKT30.39125514
114MAPK130.37902497
115CSNK1G30.37013399
116TESK20.36105235
117MAPK110.35547750
118EGFR0.35412040
119PRKCE0.34628086
120PRKAA20.34037310
121RPS6KA40.32899817
122CSNK1A1L0.31693007
123MAPK40.30720967
124MARK30.30440169
125PTK2B0.29842305
126RPS6KA60.29459831
127CSNK1G20.29445045
128HIPK20.28326222
129TNIK0.27951217
130MAPK70.27772561
131GSK3A0.26206862
132PRKG20.24790164
133STK40.24480979

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.98829127
2Other glycan degradation_Homo sapiens_hsa005112.86758653
3Complement and coagulation cascades_Homo sapiens_hsa046102.55566478
4Lysosome_Homo sapiens_hsa041422.36969819
5Type I diabetes mellitus_Homo sapiens_hsa049402.36631234
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.36301109
7Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97139899
8Histidine metabolism_Homo sapiens_hsa003401.96714407
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.91915245
10Leishmaniasis_Homo sapiens_hsa051401.84559256
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.83087663
12Steroid biosynthesis_Homo sapiens_hsa001001.79601715
13Caffeine metabolism_Homo sapiens_hsa002321.78094482
14Pertussis_Homo sapiens_hsa051331.77475835
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74062216
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70305994
17Malaria_Homo sapiens_hsa051441.62942649
18Rheumatoid arthritis_Homo sapiens_hsa053231.59227820
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56601017
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52334267
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52269112
22Osteoclast differentiation_Homo sapiens_hsa043801.51505963
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51335191
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48549392
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.47831472
26Peroxisome_Homo sapiens_hsa041461.40432945
27Graft-versus-host disease_Homo sapiens_hsa053321.39123540
28Phagosome_Homo sapiens_hsa041451.34963543
29Tryptophan metabolism_Homo sapiens_hsa003801.33366571
30Asthma_Homo sapiens_hsa053101.32906174
31Sphingolipid metabolism_Homo sapiens_hsa006001.31040373
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30893328
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30663102
34ABC transporters_Homo sapiens_hsa020101.29587423
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.26432686
36Tuberculosis_Homo sapiens_hsa051521.26157861
37Chemical carcinogenesis_Homo sapiens_hsa052041.23962265
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20191676
39Measles_Homo sapiens_hsa051621.16654051
40Allograft rejection_Homo sapiens_hsa053301.14976371
41Vitamin digestion and absorption_Homo sapiens_hsa049771.13629053
42Legionellosis_Homo sapiens_hsa051341.12244305
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12096956
44beta-Alanine metabolism_Homo sapiens_hsa004101.10062985
45Retinol metabolism_Homo sapiens_hsa008301.09352908
46Arachidonic acid metabolism_Homo sapiens_hsa005901.08729094
47Hematopoietic cell lineage_Homo sapiens_hsa046401.06933016
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05976452
49Folate biosynthesis_Homo sapiens_hsa007901.04800429
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04472798
51Protein export_Homo sapiens_hsa030601.04341254
52Fatty acid elongation_Homo sapiens_hsa000621.04247208
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02817947
54PPAR signaling pathway_Homo sapiens_hsa033200.97584282
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91979023
56Starch and sucrose metabolism_Homo sapiens_hsa005000.90667065
57Fatty acid degradation_Homo sapiens_hsa000710.90469174
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.89057416
59Nitrogen metabolism_Homo sapiens_hsa009100.86591040
60Phenylalanine metabolism_Homo sapiens_hsa003600.84827178
61Sulfur metabolism_Homo sapiens_hsa009200.84094300
62Primary immunodeficiency_Homo sapiens_hsa053400.81705408
63Influenza A_Homo sapiens_hsa051640.81597607
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.80180946
65Arginine biosynthesis_Homo sapiens_hsa002200.78956704
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78775183
67African trypanosomiasis_Homo sapiens_hsa051430.78207728
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77354290
69Antigen processing and presentation_Homo sapiens_hsa046120.76651460
70Hepatitis C_Homo sapiens_hsa051600.75664750
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74134236
72B cell receptor signaling pathway_Homo sapiens_hsa046620.72656769
73Linoleic acid metabolism_Homo sapiens_hsa005910.72186891
74TNF signaling pathway_Homo sapiens_hsa046680.71970710
75Toxoplasmosis_Homo sapiens_hsa051450.71675323
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.71432836
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71247957
78Ether lipid metabolism_Homo sapiens_hsa005650.71077176
79Autoimmune thyroid disease_Homo sapiens_hsa053200.70274993
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69866047
81Tyrosine metabolism_Homo sapiens_hsa003500.68864918
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68703754
83Apoptosis_Homo sapiens_hsa042100.67275305
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67204992
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67055045
86Arginine and proline metabolism_Homo sapiens_hsa003300.66041219
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65775365
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65524194
89Prion diseases_Homo sapiens_hsa050200.65468002
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65072391
91Phototransduction_Homo sapiens_hsa047440.64895152
92Viral myocarditis_Homo sapiens_hsa054160.64820311
93Renin-angiotensin system_Homo sapiens_hsa046140.64162353
94Mineral absorption_Homo sapiens_hsa049780.61271647
95Glutathione metabolism_Homo sapiens_hsa004800.61249407
96T cell receptor signaling pathway_Homo sapiens_hsa046600.61051518
97Salmonella infection_Homo sapiens_hsa051320.60249341
98Chemokine signaling pathway_Homo sapiens_hsa040620.59186582
99Vitamin B6 metabolism_Homo sapiens_hsa007500.59044456
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53962851
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53569320
102Fat digestion and absorption_Homo sapiens_hsa049750.51761007
103Oxidative phosphorylation_Homo sapiens_hsa001900.51605150
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49323961
105* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48675867
106Collecting duct acid secretion_Homo sapiens_hsa049660.48604882
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47821464
108Herpes simplex infection_Homo sapiens_hsa051680.46679100
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46488955
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45857135
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45855663
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44088583
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.40764408
114Selenocompound metabolism_Homo sapiens_hsa004500.39332758
115Glycerolipid metabolism_Homo sapiens_hsa005610.35257189
116Regulation of autophagy_Homo sapiens_hsa041400.34500736
117Hepatitis B_Homo sapiens_hsa051610.33292870
118Ovarian steroidogenesis_Homo sapiens_hsa049130.30456007
119Type II diabetes mellitus_Homo sapiens_hsa049300.29091238
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29058898
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28221000
122Butanoate metabolism_Homo sapiens_hsa006500.26834799
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26126823
124Dorso-ventral axis formation_Homo sapiens_hsa043200.24716633
125Systemic lupus erythematosus_Homo sapiens_hsa053220.22662556

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