P2RX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)6.75934665
2positive regulation of gamma-delta T cell activation (GO:0046645)6.50715743
3regulation of B cell receptor signaling pathway (GO:0050855)6.18120970
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.80348337
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.49137262
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.28891703
7negative regulation of cell killing (GO:0031342)5.28891703
8positive regulation of natural killer cell differentiation (GO:0032825)5.17588621
9positive thymic T cell selection (GO:0045059)5.03868856
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.03213899
11positive regulation by organism of defense response of other organism involved in symbiotic interact5.03213899
12modulation by symbiont of host immune response (GO:0052553)5.03213899
13positive regulation by symbiont of host defense response (GO:0052509)5.03213899
14modulation by symbiont of host defense response (GO:0052031)5.03213899
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.03213899
16regulation of activation of Janus kinase activity (GO:0010533)4.94993533
17T-helper 1 type immune response (GO:0042088)4.93879977
18regulation of interferon-beta biosynthetic process (GO:0045357)4.77363248
19regulation of T-helper 1 cell differentiation (GO:0045625)4.74586695
20positive regulation of B cell differentiation (GO:0045579)4.74302437
21positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.68786362
22cellular response to zinc ion (GO:0071294)4.65610630
23B cell proliferation (GO:0042100)4.64341732
24regulation of gamma-delta T cell activation (GO:0046643)4.60975920
25immunoglobulin mediated immune response (GO:0016064)4.58937662
26negative thymic T cell selection (GO:0045060)4.58538244
27regulation of sequestering of triglyceride (GO:0010889)4.56750255
28regulation of B cell differentiation (GO:0045577)4.53746643
29detection of bacterium (GO:0016045)4.50088229
30NIK/NF-kappaB signaling (GO:0038061)4.44663046
31negative T cell selection (GO:0043383)4.37591082
32regulation of gamma-delta T cell differentiation (GO:0045586)4.34663994
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.31643168
34striated muscle atrophy (GO:0014891)4.28947454
35macrophage activation involved in immune response (GO:0002281)4.27306784
36detection of other organism (GO:0098543)4.25095491
37skeletal muscle adaptation (GO:0043501)4.23472171
38thymic T cell selection (GO:0045061)4.19147001
39positive T cell selection (GO:0043368)4.10976898
40tricarboxylic acid cycle (GO:0006099)4.09288064
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.09133615
42regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.07058732
43B cell homeostasis (GO:0001782)4.05683975
44carnitine shuttle (GO:0006853)4.02975146
45plasma membrane repair (GO:0001778)3.97635597
46muscle filament sliding (GO:0030049)3.96482349
47actin-myosin filament sliding (GO:0033275)3.96482349
48T cell selection (GO:0045058)3.96040337
49positive regulation of interleukin-12 production (GO:0032735)3.95095312
50germinal center formation (GO:0002467)3.90676856
51positive regulation of T-helper cell differentiation (GO:0045624)3.89181357
52sarcomere organization (GO:0045214)3.88345060
53T cell migration (GO:0072678)3.82872676
54positive regulation of interferon-alpha production (GO:0032727)3.80243382
55fatty acid transmembrane transport (GO:1902001)3.80142986
56CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.80130982
57B cell mediated immunity (GO:0019724)3.78365985
58defense response to protozoan (GO:0042832)3.78290467
59positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.75522947
60positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.73979621
61leukocyte aggregation (GO:0070486)3.72574303
62interferon-gamma-mediated signaling pathway (GO:0060333)3.70512313
63response to interleukin-15 (GO:0070672)3.69496401
64antigen receptor-mediated signaling pathway (GO:0050851)3.69435039
65muscle atrophy (GO:0014889)3.67349617
66myofibril assembly (GO:0030239)3.65168116
67regulation of antigen processing and presentation (GO:0002577)3.62623677
68regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.62380249
69regulation of skeletal muscle contraction (GO:0014819)3.60908881
70negative regulation of lymphocyte mediated immunity (GO:0002707)3.58542383
71regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.54084363
72regulation of interferon-alpha production (GO:0032647)3.50359639
73regulation of interleukin-12 biosynthetic process (GO:0045075)3.47387374
74positive regulation of alpha-beta T cell proliferation (GO:0046641)3.47325062
75intracellular lipid transport (GO:0032365)3.46953959
76negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.43020766
77regulation of T-helper 2 cell differentiation (GO:0045628)3.42490031
78response to protozoan (GO:0001562)3.41892449
79positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.41866921
80negative regulation of phagocytosis (GO:0050765)3.39716184
81regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.38787562
82cellular response to interleukin-15 (GO:0071350)3.37685959
83positive regulation of monocyte chemotaxis (GO:0090026)3.37245398
84cardiac myofibril assembly (GO:0055003)3.36304543
85regulation of cholesterol storage (GO:0010885)3.36149394
86negative regulation of erythrocyte differentiation (GO:0045647)3.34883062
87negative regulation of T cell mediated immunity (GO:0002710)3.34402815
88response to host immune response (GO:0052572)3.34337930
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.34337930
90antigen processing and presentation via MHC class Ib (GO:0002475)3.33407271
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33195363
92positive regulation of type 2 immune response (GO:0002830)3.32526806
93lymphocyte homeostasis (GO:0002260)3.30015824
94regulation of B cell proliferation (GO:0030888)3.27849064
95growth hormone receptor signaling pathway (GO:0060396)3.26872201
96positive regulation of B cell activation (GO:0050871)3.26780813
97positive regulation of lipid storage (GO:0010884)3.25590141
98regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.25316888
99positive regulation of B cell proliferation (GO:0030890)3.25258133
100neutrophil activation involved in immune response (GO:0002283)3.24496061
101regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24038845
102positive regulation of Rap GTPase activity (GO:0032854)3.23612363
103regulation of memory T cell differentiation (GO:0043380)3.22890827
104T cell costimulation (GO:0031295)3.21657855
105negative regulation of leukocyte mediated immunity (GO:0002704)3.21657434
106sarcoplasmic reticulum calcium ion transport (GO:0070296)3.21091984
107regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.20498922
108regulation of acyl-CoA biosynthetic process (GO:0050812)3.19461183
109positive regulation of granulocyte differentiation (GO:0030854)3.17561990
110respiratory burst (GO:0045730)3.17185507
111lymphocyte costimulation (GO:0031294)3.16876644
112response to host (GO:0075136)3.16199137
113response to host defenses (GO:0052200)3.16199137
114response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.16199137
115regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.15458793
116actin-mediated cell contraction (GO:0070252)3.14727163
117myeloid dendritic cell differentiation (GO:0043011)3.14427582
118positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.12203547
119production of molecular mediator involved in inflammatory response (GO:0002532)3.11572383
120mucosal-associated lymphoid tissue development (GO:0048537)3.11154450
121Peyers patch development (GO:0048541)3.11154450
122carnitine transmembrane transport (GO:1902603)3.09984709
123detection of external biotic stimulus (GO:0098581)3.09017220
124regulation of T-helper cell differentiation (GO:0045622)3.08413798
125cellular response to virus (GO:0098586)3.07744402
126negative regulation of lipid storage (GO:0010888)3.07460868
127negative regulation of potassium ion transmembrane transport (GO:1901380)3.07195333
128T cell homeostasis (GO:0043029)3.06009946
129positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.05492535
130regulation of interleukin-12 production (GO:0032655)3.03629354
131regulation of relaxation of muscle (GO:1901077)3.02930216
132myeloid cell activation involved in immune response (GO:0002275)3.02380090
133positive regulation of antigen processing and presentation (GO:0002579)3.01892491
134regulation of interleukin-2 biosynthetic process (GO:0045076)3.01328520
135regulation of coenzyme metabolic process (GO:0051196)2.99738915
136regulation of cofactor metabolic process (GO:0051193)2.99738915
137negative regulation of interleukin-17 production (GO:0032700)2.98840380
138regulation of type I interferon-mediated signaling pathway (GO:0060338)2.98202793
139negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.97929172
140response to muramyl dipeptide (GO:0032495)2.96882535
141immune response-activating cell surface receptor signaling pathway (GO:0002429)2.96126420
142regulation of alpha-beta T cell proliferation (GO:0046640)2.94039691
143mononuclear cell proliferation (GO:0032943)2.91349071
144negative regulation of B cell proliferation (GO:0030889)2.91232050
145carnitine transport (GO:0015879)2.90833349
146amino-acid betaine transport (GO:0015838)2.90833349
147lymphocyte proliferation (GO:0046651)2.89806841
148regulation of T-helper 1 type immune response (GO:0002825)2.89767347
149regulation of fatty acid oxidation (GO:0046320)2.89740698
150regulation of B cell activation (GO:0050864)2.89689817
151regulation of natural killer cell differentiation (GO:0032823)2.89590712
152type I interferon signaling pathway (GO:0060337)2.89434168
153cellular response to type I interferon (GO:0071357)2.89434168
154leukocyte homeostasis (GO:0001776)2.88374173
155creatine metabolic process (GO:0006600)2.87639666
156lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87353334
157cellular response to interferon-alpha (GO:0035457)2.86963779
158negative regulation of cytosolic calcium ion concentration (GO:0051481)2.86938077
159NADH metabolic process (GO:0006734)2.86849109
160tricarboxylic acid metabolic process (GO:0072350)2.86151849
161response to type I interferon (GO:0034340)2.85839375
162regulation of interferon-gamma biosynthetic process (GO:0045072)2.85792085
163positive regulation of interleukin-2 production (GO:0032743)2.85763400
164regulation of immunoglobulin secretion (GO:0051023)2.84834803
165valine metabolic process (GO:0006573)2.82688964
166positive regulation of T-helper 1 type immune response (GO:0002827)2.81864169
167cellular response to growth hormone stimulus (GO:0071378)2.81202797
168positive regulation of natural killer cell activation (GO:0032816)2.80319608
169fatty acid beta-oxidation (GO:0006635)2.78296817
170negative regulation of viral genome replication (GO:0045071)2.77769812
171positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.77731058
172cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77640994
173neutrophil activation (GO:0042119)2.76832984
1742-oxoglutarate metabolic process (GO:0006103)2.76752646
175regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.76602234
176antigen processing and presentation of endogenous antigen (GO:0019883)2.74522438
177granulocyte activation (GO:0036230)2.71184293
178regulation of lipid storage (GO:0010883)2.68151672
179monocyte chemotaxis (GO:0002548)2.67941559
180muscle adaptation (GO:0043500)2.67448737
181positive regulation of interleukin-17 production (GO:0032740)2.66488278
182cellular response to interferon-beta (GO:0035458)2.65677650
183response to peptidoglycan (GO:0032494)2.61964146
184negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.60672226
185skeletal muscle contraction (GO:0003009)2.59151566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.59874294
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.58129332
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.54702267
4MYC_22102868_ChIP-Seq_BL_Human4.82848117
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.25351144
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.60263899
7VDR_21846776_ChIP-Seq_THP-1_Human3.34681644
8E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.07787316
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.86424070
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.72781028
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67569528
12MYB_26560356_Chip-Seq_TH2_Human2.64530296
13CIITA_25753668_ChIP-Seq_RAJI_Human2.62796822
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.54468328
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51725094
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.43904404
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.43573260
18UTX_26944678_Chip-Seq_JUKART_Human2.43547901
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43114688
20MYB_26560356_Chip-Seq_TH1_Human2.35260428
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28561616
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23629391
23* SPI1_23547873_ChIP-Seq_NB4_Human2.23424359
24MAF_26560356_Chip-Seq_TH2_Human2.17547380
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.16989482
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11420197
27TCF7_22412390_ChIP-Seq_EML_Mouse2.08180410
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03267394
29TRIM28_21343339_ChIP-Seq_HEK293_Human2.00926705
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99637349
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98908068
32TBX20_22080862_ChIP-Seq_HEART_Mouse1.96221272
33TBX20_22328084_ChIP-Seq_HEART_Mouse1.96221272
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95504679
35ZNF263_19887448_ChIP-Seq_K562_Human1.94807465
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94437738
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.93827261
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92127878
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91860577
40SCL_19346495_ChIP-Seq_HPC-7_Human1.80110493
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79697188
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77981957
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.76274153
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72636155
45* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70798554
46CLOCK_20551151_ChIP-Seq_293T_Human1.67976024
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66461203
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61534940
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60808725
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60310068
51GATA3_27048872_Chip-Seq_THYMUS_Human1.57175246
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55993841
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55447117
54* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54314280
55LXR_22292898_ChIP-Seq_THP-1_Human1.53075477
56VDR_24787735_ChIP-Seq_THP-1_Human1.52054396
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49137385
58PU.1_20513432_ChIP-Seq_Bcells_Mouse1.46580957
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44525392
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41360911
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39281306
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37904145
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36533500
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36413394
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35505009
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34034924
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32346134
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31664724
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29902484
70E2F7_22180533_ChIP-Seq_HELA_Human1.27785240
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27563996
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24996423
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24047952
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.23981996
75CJUN_26792858_Chip-Seq_BT549_Human1.23608927
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22795899
77EGR1_19032775_ChIP-ChIP_M12_Human1.21946847
78BCOR_27268052_Chip-Seq_Bcells_Human1.21530863
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21525992
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21500457
81BCL6_27268052_Chip-Seq_Bcells_Human1.21440298
82SPI1_23127762_ChIP-Seq_K562_Human1.21191065
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19529407
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.18819811
85RUNX_20019798_ChIP-Seq_JUKART_Human1.17900945
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16104353
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15952454
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.14726010
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.13644859
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13158464
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12208419
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.11919817
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11589403
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10854731
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10854731
96MAF_26560356_Chip-Seq_TH1_Human1.07261917
97NCOR1_26117541_ChIP-Seq_K562_Human1.07136424
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07039237
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06644953
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02233484
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02098723
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.01519456
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00991592
104ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99800466
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99709537
106P68_20966046_ChIP-Seq_HELA_Human0.99673439
107BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99088591
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97696640
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97437992
110CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96967574
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96489080
112ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96369210
113RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96302439
114SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95201150
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94564110
116* NOTCH1_21737748_ChIP-Seq_TLL_Human0.93424602
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93064549
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.93018629
119P300_27268052_Chip-Seq_Bcells_Human0.92594041
120PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92392717
121SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91920069
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91920069
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90918818
124KDM2B_26808549_Chip-Seq_DND41_Human0.90076752
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89338925
126SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88277919
127HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88247716
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87864938
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.87862032
130CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86918400
131LXR_22158963_ChIP-Seq_LIVER_Mouse0.85343520
132SPI1_20517297_ChIP-Seq_HL60_Human0.85134143
133* PU_27001747_Chip-Seq_BMDM_Mouse0.83538590
134CTCF_21964334_Chip-Seq_Bcells_Human0.83527080
135CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83443915
136ETS1_21867929_ChIP-Seq_TH2_Mouse0.83367476
137CTCF_26484167_Chip-Seq_Bcells_Mouse0.83169376
138KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82957344
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82875688
140GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82848348
141CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82787632
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82634344
143FOXP3_21729870_ChIP-Seq_TREG_Human0.82517055
144KDM2B_26808549_Chip-Seq_K562_Human0.81942552
145GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81400062
146RXR_22158963_ChIP-Seq_LIVER_Mouse0.80298688
147EGR1_19374776_ChIP-ChIP_THP-1_Human0.78193463
148RACK7_27058665_Chip-Seq_MCF-7_Human0.77948086
149CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76978425
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74795142
151P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74709231
152SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.74691098
153VDR_24763502_ChIP-Seq_THP-1_Human0.74648154
154MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.73257085
155GATA3_26560356_Chip-Seq_TH2_Human0.73096126
156* SOX2_20726797_ChIP-Seq_SW620_Human0.72391012
157CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72284759
158TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71494920
159GATA2_19941826_ChIP-Seq_K562_Human0.71258399
160GATA1_19941827_ChIP-Seq_MEL_Mouse0.70299379
161* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.69993851
162PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69549701

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.27205958
2MP0003763_abnormal_thymus_physiology3.79835348
3MP0002837_dystrophic_cardiac_calcinosis3.79419647
4MP0004084_abnormal_cardiac_muscle3.23525153
5MP0004510_myositis3.11277971
6MP0000751_myopathy3.06489278
7MP0001835_abnormal_antigen_presentation2.87110534
8MP0000749_muscle_degeneration2.78868639
9MP0004036_abnormal_muscle_relaxation2.78224754
10MP0002398_abnormal_bone_marrow2.72702728
11MP0002148_abnormal_hypersensitivity_rea2.72560116
12MP0004130_abnormal_muscle_cell2.63728881
13MP0004215_abnormal_myocardial_fiber2.49322451
14MP0000716_abnormal_immune_system2.41629541
15MP0002396_abnormal_hematopoietic_system2.40608348
16MP0005330_cardiomyopathy2.38615405
17MP0009785_altered_susceptibility_to2.35916823
18MP0008775_abnormal_heart_ventricle2.32985049
19MP0000689_abnormal_spleen_morphology2.32953045
20MP0000685_abnormal_immune_system2.32340668
21MP0004087_abnormal_muscle_fiber2.31066091
22MP0005670_abnormal_white_adipose2.16802085
23MP0009333_abnormal_splenocyte_physiolog2.13844066
24MP0001873_stomach_inflammation2.06428506
25MP0002722_abnormal_immune_system2.06417764
26MP0003436_decreased_susceptibility_to2.01553074
27MP0002429_abnormal_blood_cell1.99436381
28MP0004782_abnormal_surfactant_physiolog1.99401807
29MP0002332_abnormal_exercise_endurance1.98185798
30MP0001348_abnormal_lacrimal_gland1.96173102
31MP0000703_abnormal_thymus_morphology1.95968631
32MP0005623_abnormal_meninges_morphology1.92713515
33MP0005666_abnormal_adipose_tissue1.91643796
34MP0002106_abnormal_muscle_physiology1.89288043
35MP0001346_abnormal_lacrimal_gland1.88796538
36MP0010155_abnormal_intestine_physiology1.86310914
37MP0003183_abnormal_peptide_metabolism1.85730423
38MP0002972_abnormal_cardiac_muscle1.85560063
39MP0005451_abnormal_body_composition1.85519311
40MP0005385_cardiovascular_system_phenoty1.81808986
41MP0001544_abnormal_cardiovascular_syste1.81808986
42MP0005620_abnormal_muscle_contractility1.76311484
43MP0000750_abnormal_muscle_regeneration1.73494308
44MP0003300_gastrointestinal_ulcer1.71369971
45MP0001853_heart_inflammation1.69704448
46MP0010630_abnormal_cardiac_muscle1.67507481
47MP0003828_pulmonary_edema1.66231456
48MP0005387_immune_system_phenotype1.65766077
49MP0001790_abnormal_immune_system1.65766077
50MP0005464_abnormal_platelet_physiology1.57610418
51MP0002971_abnormal_brown_adipose1.57029003
52MP0000759_abnormal_skeletal_muscle1.56939969
53MP0005000_abnormal_immune_tolerance1.56758751
54MP0003705_abnormal_hypodermis_morpholog1.56234755
55MP0002269_muscular_atrophy1.54978374
56MP0003566_abnormal_cell_adhesion1.53015046
57MP0000343_altered_response_to1.52811606
58MP0004185_abnormal_adipocyte_glucose1.50096030
59MP0006138_congestive_heart_failure1.49772990
60MP0004233_abnormal_muscle_weight1.49371436
61MP0002006_tumorigenesis1.47727105
62MP0004947_skin_inflammation1.47307889
63MP0005025_abnormal_response_to1.45437482
64MP0005369_muscle_phenotype1.42343108
65MP0002419_abnormal_innate_immunity1.38471513
66MP0008260_abnormal_autophagy1.36818537
67MP0004808_abnormal_hematopoietic_stem1.34907935
68MP0003724_increased_susceptibility_to1.33319242
69MP0003137_abnormal_impulse_conducting1.32298651
70MP0002090_abnormal_vision1.31258117
71MP0003866_abnormal_defecation1.31008552
72MP0004381_abnormal_hair_follicle1.30736326
73MP0003191_abnormal_cellular_cholesterol1.29943662
74MP0008438_abnormal_cutaneous_collagen1.29713442
75MP0004145_abnormal_muscle_electrophysio1.29610707
76MP0002009_preneoplasia1.28611993
77MP0008057_abnormal_DNA_replication1.26383621
78MP0005671_abnormal_response_to1.26261029
79MP0005535_abnormal_body_temperature1.26251180
80MP0000465_gastrointestinal_hemorrhage1.25274951
81MP0003303_peritoneal_inflammation1.23704610
82MP0000747_muscle_weakness1.22674249
83MP0003448_altered_tumor_morphology1.22541468
84MP0003221_abnormal_cardiomyocyte_apopto1.20919715
85MP0006082_CNS_inflammation1.20312647
86MP0004484_altered_response_of1.20041366
87MP0000490_abnormal_crypts_of1.18549762
88MP0002138_abnormal_hepatobiliary_system1.18120819
89MP0000733_abnormal_muscle_development1.17808476
90MP0005375_adipose_tissue_phenotype1.16849602
91MP0006036_abnormal_mitochondrial_physio1.14442879
92MP0002452_abnormal_antigen_presenting1.13664422
93MP0009840_abnormal_foam_cell1.13541264
94MP0009764_decreased_sensitivity_to1.10274808
95MP0002723_abnormal_immune_serum1.08800186
96MP0002019_abnormal_tumor_incidence1.05911168
97MP0005075_abnormal_melanosome_morpholog1.05149706
98MP0003172_abnormal_lysosome_physiology1.04884492
99MP0005310_abnormal_salivary_gland1.03886974
100MP0002132_abnormal_respiratory_system1.03625361
101MP0003091_abnormal_cell_migration1.01123916
102MP0001800_abnormal_humoral_immune0.95887616
103MP0009115_abnormal_fat_cell0.95409816
104MP0005058_abnormal_lysosome_morphology0.95331471
105MP0005167_abnormal_blood-brain_barrier0.92502994
106MP0001986_abnormal_taste_sensitivity0.91689267
107MP0003950_abnormal_plasma_membrane0.91507711
108MP0001533_abnormal_skeleton_physiology0.91494181
109MP0001819_abnormal_immune_cell0.87374116
110MP0002933_joint_inflammation0.86638976
111MP0009278_abnormal_bone_marrow0.85516103
112MP0003077_abnormal_cell_cycle0.84966882
113MP0002166_altered_tumor_susceptibility0.84084440
114MP0005248_abnormal_Harderian_gland0.82338606
115MP0008469_abnormal_protein_level0.82293486
116MP0002420_abnormal_adaptive_immunity0.80024604
117MP0002254_reproductive_system_inflammat0.79980846
118MP0005397_hematopoietic_system_phenotyp0.79872425
119MP0001545_abnormal_hematopoietic_system0.79872425
120MP0000015_abnormal_ear_pigmentation0.79365937
121MP0001879_abnormal_lymphatic_vessel0.79360261
122MP0010094_abnormal_chromosome_stability0.78016571
123MP0001663_abnormal_digestive_system0.77819544
124MP0005166_decreased_susceptibility_to0.77499999
125MP0003186_abnormal_redox_activity0.75930111
126MP0002163_abnormal_gland_morphology0.74300291
127MP0002405_respiratory_system_inflammati0.73472441
128MP0002998_abnormal_bone_remodeling0.73151185
129MP0001845_abnormal_inflammatory_respons0.72751279
130MP0005334_abnormal_fat_pad0.72374698
131MP0006035_abnormal_mitochondrial_morpho0.71365684
132MP0002928_abnormal_bile_duct0.71250008
133MP0000313_abnormal_cell_death0.70404153
134MP0001851_eye_inflammation0.69050803
135MP0003045_fibrosis0.67986867
136MP0009763_increased_sensitivity_to0.67339401
137MP0002877_abnormal_melanocyte_morpholog0.66060072
138MP0005319_abnormal_enzyme/_coenzyme0.63507232
139MP0003111_abnormal_nucleus_morphology0.63063578
140MP0005584_abnormal_enzyme/coenzyme_acti0.62784999
141MP0008874_decreased_physiological_sensi0.62020176
142MP0002295_abnormal_pulmonary_circulatio0.61533970
143MP0000858_altered_metastatic_potential0.61397339
144MP0002693_abnormal_pancreas_physiology0.61231032
145MP0005645_abnormal_hypothalamus_physiol0.59387380
146MP0000249_abnormal_blood_vessel0.58139658
147MP0000350_abnormal_cell_proliferation0.56357029
148MP0005621_abnormal_cell_physiology0.54375342
149MP0002136_abnormal_kidney_physiology0.51828434
150MP0008961_abnormal_basal_metabolism0.51406511
151MP0000609_abnormal_liver_physiology0.46564874
152MP0003656_abnormal_erythrocyte_physiolo0.46387999
153MP0003693_abnormal_embryo_hatching0.45061136
154MP0002083_premature_death0.44519961
155MP0005076_abnormal_cell_differentiation0.41522599
156MP0004883_abnormal_blood_vessel0.40625164

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)7.46959205
2Gastrointestinal stroma tumor (HP:0100723)6.67435369
3Meningitis (HP:0001287)5.39551146
4Cellulitis (HP:0100658)5.30085254
5Exercise-induced myalgia (HP:0003738)5.23691397
6Panhypogammaglobulinemia (HP:0003139)4.97667475
7Recurrent bronchitis (HP:0002837)4.97314046
8Muscle fiber splitting (HP:0003555)4.87549032
9Sudden death (HP:0001699)4.73615538
10Lymphopenia (HP:0001888)4.69151579
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.61418644
12Exercise-induced muscle cramps (HP:0003710)4.61310029
13Myoglobinuria (HP:0002913)4.60087916
14Recurrent viral infections (HP:0004429)4.58488289
15Recurrent sinusitis (HP:0011108)4.48905329
16Hyporeflexia of lower limbs (HP:0002600)4.44250702
17Abnormality of cells of the lymphoid lineage (HP:0012140)4.35317810
18Colitis (HP:0002583)4.30625105
19Recurrent fungal infections (HP:0002841)4.29103913
20Calf muscle hypertrophy (HP:0008981)4.22900521
21Verrucae (HP:0200043)4.15874394
22Papilloma (HP:0012740)4.15874394
23Recurrent cutaneous fungal infections (HP:0011370)4.05027607
24Chronic mucocutaneous candidiasis (HP:0002728)4.05027607
25Gastrointestinal inflammation (HP:0004386)3.96414747
26Difficulty running (HP:0009046)3.94408452
27Inflammation of the large intestine (HP:0002037)3.94050869
28Muscle hypertrophy of the lower extremities (HP:0008968)3.93396649
29Increased connective tissue (HP:0009025)3.88854700
30Osteomyelitis (HP:0002754)3.84612763
31Muscle fiber inclusion bodies (HP:0100299)3.79307297
32Emphysema (HP:0002097)3.76519846
33IgM deficiency (HP:0002850)3.75871722
34Abnormality of the calf musculature (HP:0001430)3.72857669
35Ventricular tachycardia (HP:0004756)3.68894358
36Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.65164197
37Rhabdomyolysis (HP:0003201)3.60482268
38Encephalitis (HP:0002383)3.55056961
39IgA deficiency (HP:0002720)3.52502466
40Atrial fibrillation (HP:0005110)3.50406344
41Increased IgM level (HP:0003496)3.47286005
42Type 1 muscle fiber predominance (HP:0003803)3.46285637
43Lipoatrophy (HP:0100578)3.40649489
44Recurrent pneumonia (HP:0006532)3.39867601
45EMG: myopathic abnormalities (HP:0003458)3.38558452
46Recurrent skin infections (HP:0001581)3.35356613
47Obstructive lung disease (HP:0006536)3.34612698
48Chronic obstructive pulmonary disease (HP:0006510)3.34612698
49Restrictive lung disease (HP:0002091)3.29683381
50Primary atrial arrhythmia (HP:0001692)3.21883389
51Subaortic stenosis (HP:0001682)3.21629538
52Abnormality of the left ventricular outflow tract (HP:0011103)3.21629538
53Recurrent lower respiratory tract infections (HP:0002783)3.21498304
54Increased IgE level (HP:0003212)3.21019125
55IgG deficiency (HP:0004315)3.20965743
56Abnormality of T cell physiology (HP:0011840)3.20074355
57Abnormality of T cells (HP:0002843)3.16017993
58Nemaline bodies (HP:0003798)3.09994948
59Sepsis (HP:0100806)3.09347668
60Abnormality of fatty-acid metabolism (HP:0004359)3.03086634
61Supraventricular tachycardia (HP:0004755)3.00816131
62Supraventricular arrhythmia (HP:0005115)2.97461634
63Viral hepatitis (HP:0006562)2.95638719
64Lymphoma (HP:0002665)2.95240799
65Eczematoid dermatitis (HP:0000976)2.92351688
66Abnormality of B cell number (HP:0010975)2.90408783
67Right ventricular cardiomyopathy (HP:0011663)2.90118060
68B lymphocytopenia (HP:0010976)2.86543438
69Asymmetric septal hypertrophy (HP:0001670)2.83557608
70Difficulty climbing stairs (HP:0003551)2.80874001
71Muscle stiffness (HP:0003552)2.79895831
72Urticaria (HP:0001025)2.79865581
73T lymphocytopenia (HP:0005403)2.79404950
74Palpitations (HP:0001962)2.78011707
75Chronic diarrhea (HP:0002028)2.76038620
76Facial diplegia (HP:0001349)2.75551508
77Dilated cardiomyopathy (HP:0001644)2.71506268
78Bronchitis (HP:0012387)2.71251384
79Recurrent otitis media (HP:0000403)2.66399044
80Abnormality of T cell number (HP:0011839)2.66236381
81Autoimmune thrombocytopenia (HP:0001973)2.65410546
82Skin rash (HP:0000988)2.63361606
83Chest pain (HP:0100749)2.62718190
84Hydroxyprolinuria (HP:0003080)2.61884321
85Abnormality of proline metabolism (HP:0010907)2.61884321
86Prolonged QT interval (HP:0001657)2.61209768
87Increased muscle lipid content (HP:0009058)2.59479991
88Frequent falls (HP:0002359)2.58244596
89Recurrent abscess formation (HP:0002722)2.54779748
90Hypoplasia of the thymus (HP:0000778)2.54584701
91Tetraparesis (HP:0002273)2.54519885
92Granulocytopenia (HP:0001913)2.54031698
93Spontaneous hematomas (HP:0007420)2.53573022
94Bundle branch block (HP:0011710)2.53450539
95Stomatitis (HP:0010280)2.53135886
96Pulmonary infiltrates (HP:0002113)2.52577097
97Prolonged bleeding time (HP:0003010)2.52393878
98Congenital stationary night blindness (HP:0007642)2.52145141
99Pustule (HP:0200039)2.51916558
100Chronic otitis media (HP:0000389)2.49282388
101Hypoglycemic coma (HP:0001325)2.43518714
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40934992
103Basal ganglia calcification (HP:0002135)2.40476201
104Axonal loss (HP:0003447)2.37586880
105Abnormality of skeletal muscle fiber size (HP:0012084)2.34850859
106Central scotoma (HP:0000603)2.34702901
107Increased variability in muscle fiber diameter (HP:0003557)2.34222834
108Skin ulcer (HP:0200042)2.34017695
109Distal lower limb muscle weakness (HP:0009053)2.33634684
110Syncope (HP:0001279)2.33553164
111Retrobulbar optic neuritis (HP:0100654)2.33202913
112Optic neuritis (HP:0100653)2.33202913
113Leukopenia (HP:0001882)2.32853769
114Chronic sinusitis (HP:0011109)2.31624698
115Orchitis (HP:0100796)2.31621698
116Generalized aminoaciduria (HP:0002909)2.31433162
117Malignant hyperthermia (HP:0002047)2.29810787
118Myotonia (HP:0002486)2.29798391
119Gastrointestinal infarctions (HP:0005244)2.29344706
120Ventricular arrhythmia (HP:0004308)2.28696036
121Generalized muscle weakness (HP:0003324)2.28620704
122Basal cell carcinoma (HP:0002671)2.27969683
123Recurrent bacterial skin infections (HP:0005406)2.27901653
124Distal arthrogryposis (HP:0005684)2.25571337
125Neck muscle weakness (HP:0000467)2.25484387
126Cerebral hemorrhage (HP:0001342)2.24009659
127Dicarboxylic aciduria (HP:0003215)2.23889756
128Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23889756
129Vasculitis (HP:0002633)2.22647265
130Abnormality of the prostate (HP:0008775)2.22248965
131Distal lower limb amyotrophy (HP:0008944)2.21660387
132Neoplasm of head and neck (HP:0012288)2.20469259
133Esophageal neoplasm (HP:0100751)2.20469259
134Recurrent gram-negative bacterial infections (HP:0005420)2.14519010
135Ketoacidosis (HP:0001993)2.13980021
136Heart block (HP:0012722)2.13969227
137Tinnitus (HP:0000360)2.13809228
138Autoimmune hemolytic anemia (HP:0001890)2.13049065
139Abnormality of macrophages (HP:0004311)2.12738869
140Hyperglycinuria (HP:0003108)2.09954079
141Hepatic necrosis (HP:0002605)2.09913068
142Mediastinal lymphadenopathy (HP:0100721)2.09611393
143Gowers sign (HP:0003391)2.09412395
144Abnormal atrioventricular conduction (HP:0005150)2.08152550
145Severe combined immunodeficiency (HP:0004430)2.08047912
146Keratoconjunctivitis sicca (HP:0001097)2.07854165
147Hypochromic anemia (HP:0001931)2.05867600
148Hypergammaglobulinemia (HP:0010702)2.05689191
149Porencephaly (HP:0002132)2.05233273
150Atrioventricular block (HP:0001678)2.04601848
151Epistaxis (HP:0000421)2.02815095
152Hemoptysis (HP:0002105)2.01923507
153Hepatitis (HP:0012115)1.97672374
154Areflexia of lower limbs (HP:0002522)1.97154113
155Keratoconjunctivitis (HP:0001096)1.96490414
156Abnormality of the pleura (HP:0002103)1.95508442
157Aplasia/Hypoplasia of the thymus (HP:0010515)1.95327198
158Abnormality of the fingertips (HP:0001211)1.94642085
159Elevated erythrocyte sedimentation rate (HP:0003565)1.94293378
160Eosinophilia (HP:0001880)1.94171424
161Arthralgia (HP:0002829)1.92855373
162Fatigue (HP:0012378)1.91998357
163Neutropenia (HP:0001875)1.91187758
164Hypertensive crisis (HP:0100735)1.90790289
165Gingivitis (HP:0000230)1.90055038
166Lower limb amyotrophy (HP:0007210)1.89462220
167Leukocytosis (HP:0001974)1.88868563
168Myopathic facies (HP:0002058)1.88678869
169Papilledema (HP:0001085)1.87607746
170Pheochromocytoma (HP:0002666)1.86986380
171Abnormality of the peritoneum (HP:0002585)1.84916372
172Albinism (HP:0001022)1.83764850
173Scapular winging (HP:0003691)1.83635969
174Increased intramyocellular lipid droplets (HP:0012240)1.82214650
175Arterial thrombosis (HP:0004420)1.81966355
176Proximal tubulopathy (HP:0000114)1.80904964
177Myositis (HP:0100614)1.79241743
178Abnormality of small intestinal villus morphology (HP:0011472)1.79144799
179Villous atrophy (HP:0011473)1.79144799
180Ventricular fibrillation (HP:0001663)1.79069826
181Muscular dystrophy (HP:0003560)1.78417030
182Hyperalaninemia (HP:0003348)1.76379352
183Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76379352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.51014339
2TTN4.00296481
3PRPF4B3.65235407
4OBSCN3.12335248
5MAP3K102.75645298
6TBK12.68404510
7TRIB32.50122087
8PIM22.38170393
9TYK22.37042572
10JAK32.36600753
11BCKDK2.36085146
12BTK2.27900579
13PHKG12.25016614
14PHKG22.25016614
15MAP3K132.13239809
16SMG12.10049274
17IKBKB2.09428273
18PDK32.04723152
19PDK42.04723152
20SIK21.84656099
21RIPK41.82702008
22JAK11.79215108
23TNK21.77648136
24EPHB11.77403382
25SIK31.68344399
26FES1.65738580
27DMPK1.63388571
28EPHA31.62949472
29ARAF1.60708599
30BMX1.58901074
31LMTK21.55726562
32LYN1.54113014
33GRK61.48855689
34CSF1R1.48847330
35PDK21.46335108
36CHUK1.42751918
37NEK91.37224615
38PKN21.34311420
39IKBKE1.33848849
40RIPK11.31736583
41ITK1.23909815
42MAP3K51.21022522
43MAP3K71.13886251
44CDK41.13730915
45BMPR21.09705238
46STK101.08539711
47TEC1.08363329
48IRAK41.08362527
49LCK1.07908983
50IRAK31.07619389
51STK241.05392570
52SIK11.04332116
53TXK1.04141235
54TAOK11.03656133
55PINK11.02235039
56MYLK0.98170647
57MAP3K110.95189686
58CDC42BPA0.93309892
59BLK0.92790250
60PIK3CA0.92479412
61PBK0.91106323
62CAMK1D0.88733856
63ABL20.85778486
64MARK20.85582264
65KIT0.85560398
66JAK20.85391413
67FGFR40.84142314
68EEF2K0.83772100
69NEK10.83003649
70TRPM70.82067322
71PDK10.80069739
72PKN10.77840286
73MAP3K80.77659203
74MARK30.76859345
75MAP2K30.76728349
76RAF10.74335216
77PRKAA20.73517987
78TAOK20.73213674
79TESK20.71641994
80PRKAA10.70380223
81PTK2B0.69646231
82MOS0.69414568
83DAPK30.68419001
84STK40.67691186
85MAPK120.66039945
86PIM10.65582219
87EIF2AK20.64725984
88PASK0.64570432
89NME20.64149712
90ZAK0.63212390
91FGR0.63120569
92PIK3CG0.62793963
93LRRK20.62497109
94PAK30.62234450
95SYK0.61495832
96PRKD20.60415509
97MUSK0.60164047
98FGFR30.59982807
99WNK10.58553124
100CSK0.57505591
101PRKD10.57268893
102KSR20.56727829
103STK38L0.56315270
104MAP4K10.55996741
105ICK0.55889000
106TIE10.54808158
107HIPK20.54286855
108ROCK10.53889508
109MAPK70.53659935
110FLT30.53518162
111HCK0.52387065
112MAP3K90.52358029
113RPS6KA10.51163085
114FYN0.50892306
115IRAK20.50546770
116PTK60.50527583
117PDPK10.50354227
118CDK190.48456724
119GRK70.48276233
120TGFBR20.47482278
121IRAK10.47192192
122ILK0.46036682
123ERBB30.45951281
124PDGFRA0.44089127
125INSRR0.43728451
126WNK40.43551728
127ERN10.42882153
128TESK10.42783382
129ZAP700.42479203
130PRKACG0.41177932
131MAPK40.39499643
132MAP3K30.39389566
133BRD40.39047112
134MELK0.38457037
135MAPK110.37532099
136BCR0.37443442
137MAP3K10.37216051
138TAOK30.37170427
139PRKCD0.37026315
140PRKCH0.36302872
141CAMKK10.35931537
142PRKCE0.35663795
143PRKCQ0.35517174
144TLK10.33861717
145RET0.33824082
146ALK0.33239805
147MAPKAPK20.33123984
148CDK120.32525311
149MAP2K20.32220653
150KDR0.32007446
151YES10.29267325
152STK110.28543376
153MATK0.27827305
154NLK0.26838831
155CDK90.25484662
156MAPK30.23492415

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.41982802
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.82034173
3Allograft rejection_Homo sapiens_hsa053303.35593897
4Graft-versus-host disease_Homo sapiens_hsa053323.19035086
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.98697006
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.56733584
7Antigen processing and presentation_Homo sapiens_hsa046122.41594786
8Propanoate metabolism_Homo sapiens_hsa006402.37041203
9Viral myocarditis_Homo sapiens_hsa054162.29037680
10Type I diabetes mellitus_Homo sapiens_hsa049402.17929397
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12287859
12Leishmaniasis_Homo sapiens_hsa051402.06067906
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.04986719
14Fatty acid degradation_Homo sapiens_hsa000712.02467407
15Hematopoietic cell lineage_Homo sapiens_hsa046401.97715363
16Cardiac muscle contraction_Homo sapiens_hsa042601.94243596
17Dilated cardiomyopathy_Homo sapiens_hsa054141.94241958
18Autoimmune thyroid disease_Homo sapiens_hsa053201.81250046
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.76082622
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75834558
21T cell receptor signaling pathway_Homo sapiens_hsa046601.72207510
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69523236
23Fatty acid metabolism_Homo sapiens_hsa012121.59050721
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.57267309
25Measles_Homo sapiens_hsa051621.56423313
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.54931622
27Carbon metabolism_Homo sapiens_hsa012001.52230384
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50724012
29Rheumatoid arthritis_Homo sapiens_hsa053231.49478979
30Systemic lupus erythematosus_Homo sapiens_hsa053221.48974564
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48831078
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46269870
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45203701
34Legionellosis_Homo sapiens_hsa051341.42524858
35Epstein-Barr virus infection_Homo sapiens_hsa051691.36996870
36Toxoplasmosis_Homo sapiens_hsa051451.35450255
37Osteoclast differentiation_Homo sapiens_hsa043801.32316165
38PPAR signaling pathway_Homo sapiens_hsa033201.29753407
39TNF signaling pathway_Homo sapiens_hsa046681.29385380
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29302867
41Influenza A_Homo sapiens_hsa051641.28107379
42Pertussis_Homo sapiens_hsa051331.28008283
43Malaria_Homo sapiens_hsa051441.25689094
44Tuberculosis_Homo sapiens_hsa051521.22350050
45Non-small cell lung cancer_Homo sapiens_hsa052231.17762957
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16992648
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11200542
48HTLV-I infection_Homo sapiens_hsa051661.10678158
49Viral carcinogenesis_Homo sapiens_hsa052031.07123810
50Fatty acid biosynthesis_Homo sapiens_hsa000611.02370711
51Insulin resistance_Homo sapiens_hsa049311.01194654
52Salmonella infection_Homo sapiens_hsa051321.00745695
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.99308163
54African trypanosomiasis_Homo sapiens_hsa051430.96664845
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91272577
56Oxidative phosphorylation_Homo sapiens_hsa001900.91020545
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90213399
58Parkinsons disease_Homo sapiens_hsa050120.90069699
59Amoebiasis_Homo sapiens_hsa051460.88673721
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88336560
61Apoptosis_Homo sapiens_hsa042100.86573586
62HIF-1 signaling pathway_Homo sapiens_hsa040660.82647080
63Chemokine signaling pathway_Homo sapiens_hsa040620.81831891
64Herpes simplex infection_Homo sapiens_hsa051680.80703627
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79096553
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78546774
67Pancreatic cancer_Homo sapiens_hsa052120.77306568
68Pyruvate metabolism_Homo sapiens_hsa006200.76605998
69Alzheimers disease_Homo sapiens_hsa050100.72862362
70Shigellosis_Homo sapiens_hsa051310.71994266
71Acute myeloid leukemia_Homo sapiens_hsa052210.70486414
72Type II diabetes mellitus_Homo sapiens_hsa049300.69610108
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67710759
74Platelet activation_Homo sapiens_hsa046110.66377579
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.64909591
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63905395
77Insulin signaling pathway_Homo sapiens_hsa049100.63800342
78Asthma_Homo sapiens_hsa053100.63393170
79Prion diseases_Homo sapiens_hsa050200.59990764
80Phagosome_Homo sapiens_hsa041450.58171690
81Other glycan degradation_Homo sapiens_hsa005110.57726040
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.57250703
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56578396
84AMPK signaling pathway_Homo sapiens_hsa041520.56413006
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55234814
86Colorectal cancer_Homo sapiens_hsa052100.54897315
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53753101
88B cell receptor signaling pathway_Homo sapiens_hsa046620.53230269
89Staphylococcus aureus infection_Homo sapiens_hsa051500.52340641
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51683741
91Prolactin signaling pathway_Homo sapiens_hsa049170.49954890
92Renal cell carcinoma_Homo sapiens_hsa052110.48903479
93Tryptophan metabolism_Homo sapiens_hsa003800.47351387
94Base excision repair_Homo sapiens_hsa034100.47126094
95Focal adhesion_Homo sapiens_hsa045100.46860179
96Alcoholism_Homo sapiens_hsa050340.46732208
97Fructose and mannose metabolism_Homo sapiens_hsa000510.46623527
98DNA replication_Homo sapiens_hsa030300.46490476
99Starch and sucrose metabolism_Homo sapiens_hsa005000.45407878
100Hepatitis C_Homo sapiens_hsa051600.45343701
101Chronic myeloid leukemia_Homo sapiens_hsa052200.43893396
102Lysosome_Homo sapiens_hsa041420.43595772
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43455585
104Endometrial cancer_Homo sapiens_hsa052130.43293628
105GnRH signaling pathway_Homo sapiens_hsa049120.42371594
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42117905
107Inositol phosphate metabolism_Homo sapiens_hsa005620.40565295
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.40001983
109Notch signaling pathway_Homo sapiens_hsa043300.39951018
110Hepatitis B_Homo sapiens_hsa051610.39058547
111Proteoglycans in cancer_Homo sapiens_hsa052050.39047258
112MAPK signaling pathway_Homo sapiens_hsa040100.38507114
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.38070617
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38063989
115FoxO signaling pathway_Homo sapiens_hsa040680.38059459
116Choline metabolism in cancer_Homo sapiens_hsa052310.37501554
117mTOR signaling pathway_Homo sapiens_hsa041500.35313703
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34351243
119beta-Alanine metabolism_Homo sapiens_hsa004100.34173570
120Oxytocin signaling pathway_Homo sapiens_hsa049210.33992881
121Biosynthesis of amino acids_Homo sapiens_hsa012300.33901662
122Galactose metabolism_Homo sapiens_hsa000520.33797290
123VEGF signaling pathway_Homo sapiens_hsa043700.33202634
124Peroxisome_Homo sapiens_hsa041460.32986912
125Prostate cancer_Homo sapiens_hsa052150.32344020
126Phenylalanine metabolism_Homo sapiens_hsa003600.31296864
127ECM-receptor interaction_Homo sapiens_hsa045120.30696896
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30111969
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.29737751
130Small cell lung cancer_Homo sapiens_hsa052220.29628693
131Endocytosis_Homo sapiens_hsa041440.28543645
132Glioma_Homo sapiens_hsa052140.27896823
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27857331
134Butanoate metabolism_Homo sapiens_hsa006500.27543611
135Adherens junction_Homo sapiens_hsa045200.27407258
136Huntingtons disease_Homo sapiens_hsa050160.27102448
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26667054
138Pentose phosphate pathway_Homo sapiens_hsa000300.26221873
139Non-homologous end-joining_Homo sapiens_hsa034500.26173200
140ErbB signaling pathway_Homo sapiens_hsa040120.25709030
141Long-term potentiation_Homo sapiens_hsa047200.24369697
142Spliceosome_Homo sapiens_hsa030400.23852482
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.18275228
144Thyroid cancer_Homo sapiens_hsa052160.18052878
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17085294
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16172981
147mRNA surveillance pathway_Homo sapiens_hsa030150.13027796

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