ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.60079511
2	DNA deamination (GO:0045006)	4.75515803
3	L-fucose catabolic process (GO:0042355)	4.13895041
4	fucose catabolic process (GO:0019317)	4.13895041
5	L-fucose metabolic process (GO:0042354)	4.13895041
6	respiratory chain complex IV assembly (GO:0008535)	4.10940594
7	water-soluble vitamin biosynthetic process (GO:0042364)	4.09104979
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.94158508
9	NADH dehydrogenase complex assembly (GO:0010257)	3.94158508
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.94158508
11	protein complex biogenesis (GO:0070271)	3.92362335
12	mitochondrial respiratory chain complex assembly (GO:0033108)	3.71378650
13	negative regulation of telomere maintenance (GO:0032205)	3.68299647
14	cytochrome complex assembly (GO:0017004)	3.65582799
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.49142027
16	detection of light stimulus involved in visual perception (GO:0050908)	3.49142027
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.43578028
18	platelet dense granule organization (GO:0060155)	3.42508147
19	response to pheromone (GO:0019236)	3.41201801
20	preassembly of GPI anchor in ER membrane (GO:0016254)	3.39440790
21	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.36193800
22	cellular ketone body metabolic process (GO:0046950)	3.12434134
23	indolalkylamine metabolic process (GO:0006586)	3.07906073
24	protein-cofactor linkage (GO:0018065)	3.06455947
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.06076103
26	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.02246370
27	mannosylation (GO:0097502)	2.99405181
28	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97578107
29	tryptophan catabolic process (GO:0006569)	2.97344573
30	indole-containing compound catabolic process (GO:0042436)	2.97344573
31	indolalkylamine catabolic process (GO:0046218)	2.97344573
32	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.96226118
33	piRNA metabolic process (GO:0034587)	2.95304348
34	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.94022707
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.93346568
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.93346568
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.91773313
38	ATP synthesis coupled proton transport (GO:0015986)	2.91773313
39	recombinational repair (GO:0000725)	2.91427526
40	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.91054244
41	reciprocal meiotic recombination (GO:0007131)	2.89688732
42	reciprocal DNA recombination (GO:0035825)	2.89688732
43	kynurenine metabolic process (GO:0070189)	2.88789222
44	double-strand break repair via homologous recombination (GO:0000724)	2.88506157
45	rRNA modification (GO:0000154)	2.88315760
46	epithelial cilium movement (GO:0003351)	2.86927918
47	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.85529834
48	termination of RNA polymerase III transcription (GO:0006386)	2.85529834
49	peptidyl-histidine modification (GO:0018202)	2.84572986
50	cellular response to ATP (GO:0071318)	2.83271902
51	ketone body metabolic process (GO:1902224)	2.83108405
52	synaptic transmission, cholinergic (GO:0007271)	2.81957880
53	replication fork processing (GO:0031297)	2.81340190
54	pseudouridine synthesis (GO:0001522)	2.80626911
55	axoneme assembly (GO:0035082)	2.76161691
56	rRNA catabolic process (GO:0016075)	2.74039349
57	tRNA processing (GO:0008033)	2.73879651
58	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.73363307
59	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.72425644
60	centriole replication (GO:0007099)	2.68748119
61	positive regulation of prostaglandin secretion (GO:0032308)	2.68710675
62	rRNA methylation (GO:0031167)	2.68058161
63	cornea development in camera-type eye (GO:0061303)	2.64070356
64	DNA double-strand break processing (GO:0000729)	2.63308850
65	base-excision repair, AP site formation (GO:0006285)	2.62587113
66	chaperone-mediated protein transport (GO:0072321)	2.61370855
67	GPI anchor metabolic process (GO:0006505)	2.60787946
68	retinal cone cell development (GO:0046549)	2.60418645
69	tryptophan metabolic process (GO:0006568)	2.59555112
70	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.58364052
71	isotype switching (GO:0045190)	2.58364052
72	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.58364052
73	regulation of action potential (GO:0098900)	2.58294218
74	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.58277210
75	regulation of mitotic spindle checkpoint (GO:1903504)	2.58277210
76	S-adenosylmethionine metabolic process (GO:0046500)	2.57313607
77	nonmotile primary cilium assembly (GO:0035058)	2.57100163
78	negative regulation of mast cell activation (GO:0033004)	2.55968434
79	mitotic cell cycle arrest (GO:0071850)	2.55462005
80	ubiquinone biosynthetic process (GO:0006744)	2.54765549
81	cilium morphogenesis (GO:0060271)	2.53217841
82	electron transport chain (GO:0022900)	2.52593866
83	sulfation (GO:0051923)	2.52214539
84	meiotic chromosome segregation (GO:0045132)	2.51627912
85	protein K11-linked deubiquitination (GO:0035871)	2.51361959
86	tRNA modification (GO:0006400)	2.51209611
87	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.50152886
88	protein polyglutamylation (GO:0018095)	2.49441902
89	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.49250371
90	multicellular organism reproduction (GO:0032504)	2.48867580
91	kidney morphogenesis (GO:0060993)	2.47766255
92	photoreceptor cell development (GO:0042461)	2.46948060
93	regulation of glucokinase activity (GO:0033131)	2.45115075
94	regulation of hexokinase activity (GO:1903299)	2.45115075
95	regulation of telomere maintenance (GO:0032204)	2.44565720
96	respiratory electron transport chain (GO:0022904)	2.44294471
97	positive regulation of fatty acid transport (GO:2000193)	2.43154767
98	DNA demethylation (GO:0080111)	2.43013568
99	regulation of cilium movement (GO:0003352)	2.42504367
100	regulation of mesoderm development (GO:2000380)	2.42085350

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.12428604
2	VDR_22108803_ChIP-Seq_LS180_Human	3.21000634
3	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.88495971
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.76794670
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.61005251
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.55767790
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.51315616
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.43798113
9	EWS_26573619_Chip-Seq_HEK293_Human	2.36642577
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.34102027
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.30179392
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.29205213
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.23065073
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.19966289
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.17335191
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.10842990
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.10769552
18	FUS_26573619_Chip-Seq_HEK293_Human	2.09911260
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.01754837
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.96499809
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.93662053
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.93234543
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88969168
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.83117073
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.82963556
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.82680320
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81749866
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.81190758
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.80573333
30	P300_19829295_ChIP-Seq_ESCs_Human	1.79056772
31	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.70779044
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.69719725
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69483626
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68192415
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.65291796
36	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.63000530
37	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.58377465
38	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.46343803
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.44903740
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.42779202
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.40305550
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39394313
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39394313
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39330291
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37407085
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37407085
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.34177471
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34177471
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29937229
50	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29929914
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26707436
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25114404
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.24899335
54	AR_20517297_ChIP-Seq_VCAP_Human	1.24224266
55	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23304108
56	NCOR_22424771_ChIP-Seq_293T_Human	1.22315601
57	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.21849043
58	HOXB7_26014856_ChIP-Seq_BT474_Human	1.20754321
59	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.19372844
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18904318
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17599031
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17599031
63	STAT3_23295773_ChIP-Seq_U87_Human	1.17507194
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17021435
65	AR_25329375_ChIP-Seq_VCAP_Human	1.14393233
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13566959
67	TCF4_23295773_ChIP-Seq_U87_Human	1.13547180
68	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.12159338
69	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12053283
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10931536
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.09668653
72	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.09397597
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08359401
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07147137
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05337193
76	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05173493
77	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05053482
78	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.04635889
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03490728
80	ERA_21632823_ChIP-Seq_H3396_Human	1.03245833
81	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02730197
82	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02526580
83	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01756831
84	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.01384254
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99684394
86	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.99630500
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.99537842
88	GATA3_26560356_Chip-Seq_TH2_Human	0.99256925
89	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99156670
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98613703
91	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.98322575
92	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98304873
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97793650
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96388111
95	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.96133338
96	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.95375916
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.94895916
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93681312
99	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93464038
100	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.93096012

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.80020817
2	MP0000569_abnormal_digit_pigmentation	2.74666329
3	MP0001986_abnormal_taste_sensitivity	2.67947118
4	MP0003195_calcinosis	2.67873454
5	MP0002102_abnormal_ear_morphology	2.60260222
6	MP0005174_abnormal_tail_pigmentation	2.39369115
7	MP0005551_abnormal_eye_electrophysiolog	2.36788424
8	MP0001968_abnormal_touch/_nociception	2.35329757
9	MP0006292_abnormal_olfactory_placode	2.25950084
10	MP0002638_abnormal_pupillary_reflex	2.19258067
11	MP0002837_dystrophic_cardiac_calcinosis	2.14047306
12	MP0008058_abnormal_DNA_repair	1.98561655
13	MP0008872_abnormal_physiological_respon	1.98051530
14	MP0004142_abnormal_muscle_tone	1.97623372
15	MP0005084_abnormal_gallbladder_morpholo	1.97610719
16	MP0006072_abnormal_retinal_apoptosis	1.95579854
17	MP0002736_abnormal_nociception_after	1.94527942
18	MP0008875_abnormal_xenobiotic_pharmacok	1.87549194
19	MP0004043_abnormal_pH_regulation	1.83020286
20	MP0003646_muscle_fatigue	1.82573738
21	MP0002876_abnormal_thyroid_physiology	1.81281248
22	MP0003136_yellow_coat_color	1.77863402
23	MP0005253_abnormal_eye_physiology	1.77732018
24	MP0003787_abnormal_imprinting	1.75353439
25	MP0004885_abnormal_endolymph	1.68214912
26	MP0009046_muscle_twitch	1.67950030
27	MP0002938_white_spotting	1.58274833
28	MP0009745_abnormal_behavioral_response	1.57132352
29	MP0005646_abnormal_pituitary_gland	1.54611890
30	MP0000372_irregular_coat_pigmentation	1.53074228
31	MP0003011_delayed_dark_adaptation	1.52936467
32	MP0001529_abnormal_vocalization	1.47413312
33	MP0000427_abnormal_hair_cycle	1.45492967
34	MP0004147_increased_porphyrin_level	1.44357324
35	MP0003718_maternal_effect	1.39538127
36	MP0002272_abnormal_nervous_system	1.35951254
37	MP0005423_abnormal_somatic_nervous	1.32364292
38	MP0005075_abnormal_melanosome_morpholog	1.30348512
39	MP0004133_heterotaxia	1.30185626
40	MP0002735_abnormal_chemical_nociception	1.30097624
41	MP0006276_abnormal_autonomic_nervous	1.29534994
42	MP0000631_abnormal_neuroendocrine_gland	1.28615863
43	MP0002277_abnormal_respiratory_mucosa	1.28373650
44	MP0002928_abnormal_bile_duct	1.28345143
45	MP0002653_abnormal_ependyma_morphology	1.26144361
46	MP0001485_abnormal_pinna_reflex	1.24513434
47	MP0002095_abnormal_skin_pigmentation	1.23683576
48	MP0005645_abnormal_hypothalamus_physiol	1.21064399
49	MP0005389_reproductive_system_phenotype	1.20949990
50	MP0001501_abnormal_sleep_pattern	1.18966988
51	MP0004742_abnormal_vestibular_system	1.16603534
52	MP0000015_abnormal_ear_pigmentation	1.15681748
53	MP0001486_abnormal_startle_reflex	1.14952721
54	MP0001919_abnormal_reproductive_system	1.14585740
55	MP0001905_abnormal_dopamine_level	1.13529352
56	MP0003880_abnormal_central_pattern	1.08770355
57	MP0002138_abnormal_hepatobiliary_system	1.08556409
58	MP0008961_abnormal_basal_metabolism	1.07350422
59	MP0001188_hyperpigmentation	1.06618347
60	MP0006036_abnormal_mitochondrial_physio	1.06173998
61	MP0008995_early_reproductive_senescence	1.05279274
62	MP0001984_abnormal_olfaction	1.03733207
63	MP0005083_abnormal_biliary_tract	1.03486601
64	MP0003786_premature_aging	1.02859464
65	MP0001502_abnormal_circadian_rhythm	1.02562662
66	MP0002160_abnormal_reproductive_system	1.02519465
67	MP0002572_abnormal_emotion/affect_behav	0.98717309
68	MP0005410_abnormal_fertilization	0.98119991
69	MP0010386_abnormal_urinary_bladder	0.98040297
70	MP0002064_seizures	0.96187776
71	MP0001970_abnormal_pain_threshold	0.94789500
72	MP0010094_abnormal_chromosome_stability	0.93188206
73	MP0001324_abnormal_eye_pigmentation	0.92035760
74	MP0003806_abnormal_nucleotide_metabolis	0.91890081
75	MP0002163_abnormal_gland_morphology	0.90836962
76	MP0002067_abnormal_sensory_capabilities	0.90112251
77	MP0002557_abnormal_social/conspecific_i	0.90081395
78	MP0005195_abnormal_posterior_eye	0.88840031
79	MP0005386_behavior/neurological_phenoty	0.88187960
80	MP0004924_abnormal_behavior	0.88187960
81	MP0002234_abnormal_pharynx_morphology	0.87964284
82	MP0004145_abnormal_muscle_electrophysio	0.87761525
83	MP0005671_abnormal_response_to	0.86842255
84	MP0005171_absent_coat_pigmentation	0.86303914
85	MP0005377_hearing/vestibular/ear_phenot	0.85086210
86	MP0003878_abnormal_ear_physiology	0.85086210
87	MP0005332_abnormal_amino_acid	0.84992480
88	MP0006035_abnormal_mitochondrial_morpho	0.84183916
89	MP0001929_abnormal_gametogenesis	0.83455816
90	MP0002210_abnormal_sex_determination	0.83031143
91	MP0004215_abnormal_myocardial_fiber	0.82622332
92	MP0003252_abnormal_bile_duct	0.81312872
93	MP0001764_abnormal_homeostasis	0.80789745
94	MP0000538_abnormal_urinary_bladder	0.80734342
95	MP0003698_abnormal_male_reproductive	0.79059482
96	MP0002693_abnormal_pancreas_physiology	0.76444526
97	MP0001293_anophthalmia	0.76272433
98	MP0002751_abnormal_autonomic_nervous	0.75834851
99	MP0008789_abnormal_olfactory_epithelium	0.75744079
100	MP0002254_reproductive_system_inflammat	0.75411616

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.11899538
2	Congenital stationary night blindness (HP:0007642)	3.95559308
3	Molar tooth sign on MRI (HP:0002419)	3.92954933
4	Abnormality of midbrain morphology (HP:0002418)	3.92954933
5	Pancreatic fibrosis (HP:0100732)	3.68015658
6	True hermaphroditism (HP:0010459)	3.41354844
7	Nephronophthisis (HP:0000090)	3.31057069
8	Attenuation of retinal blood vessels (HP:0007843)	3.18199017
9	Abnormality of the renal cortex (HP:0011035)	2.93616693
10	Abnormality of the renal medulla (HP:0100957)	2.91626612
11	Mitochondrial inheritance (HP:0001427)	2.90890423
12	Acute necrotizing encephalopathy (HP:0006965)	2.87500995
13	Increased CSF lactate (HP:0002490)	2.79411666
14	Medial flaring of the eyebrow (HP:0010747)	2.77171068
15	Abnormality of alanine metabolism (HP:0010916)	2.74144090
16	Hyperalaninemia (HP:0003348)	2.74144090
17	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.74144090
18	Methylmalonic acidemia (HP:0002912)	2.70772583
19	Pendular nystagmus (HP:0012043)	2.63242628
20	Lipid accumulation in hepatocytes (HP:0006561)	2.58762477
21	Chronic hepatic failure (HP:0100626)	2.57266641
22	Hepatocellular necrosis (HP:0001404)	2.54058611
23	Acute encephalopathy (HP:0006846)	2.53834525
24	Methylmalonic aciduria (HP:0012120)	2.51981110
25	Progressive macrocephaly (HP:0004481)	2.50214923
26	Increased hepatocellular lipid droplets (HP:0006565)	2.48541824
27	Abnormal mitochondria in muscle tissue (HP:0008316)	2.48228280
28	Abnormal drinking behavior (HP:0030082)	2.45250118
29	Polydipsia (HP:0001959)	2.45250118
30	Abolished electroretinogram (ERG) (HP:0000550)	2.44132861
31	Type II lissencephaly (HP:0007260)	2.39685321
32	Hypoplasia of the pons (HP:0012110)	2.36920242
33	Hepatic necrosis (HP:0002605)	2.36741917
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.35441371
35	Abnormality of the pons (HP:0007361)	2.35177564
36	3-Methylglutaconic aciduria (HP:0003535)	2.35152845
37	Tubular atrophy (HP:0000092)	2.32480928
38	Cystic liver disease (HP:0006706)	2.30850805
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.30671903
40	Congenital, generalized hypertrichosis (HP:0004540)	2.27607289
41	Hyperventilation (HP:0002883)	2.24764685
42	Decreased central vision (HP:0007663)	2.18678156
43	Optic disc pallor (HP:0000543)	2.18555905
44	Renal cortical cysts (HP:0000803)	2.18470288
45	Bony spicule pigmentary retinopathy (HP:0007737)	2.17079322
46	Sclerocornea (HP:0000647)	2.16880833
47	Inability to walk (HP:0002540)	2.14645304
48	Rib fusion (HP:0000902)	2.12961355
49	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.09093008
50	Polyuria (HP:0000103)	2.08535506
51	Progressive inability to walk (HP:0002505)	2.08171361
52	Abnormal number of erythroid precursors (HP:0012131)	2.07026863
53	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.06411299
54	Gait imbalance (HP:0002141)	2.04652846
55	Stomach cancer (HP:0012126)	2.04151036
56	Increased serum lactate (HP:0002151)	2.03967759
57	Absent thumb (HP:0009777)	2.01509061
58	Bile duct proliferation (HP:0001408)	2.00681314
59	Abnormal biliary tract physiology (HP:0012439)	2.00681314
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.00580566
61	Patellar aplasia (HP:0006443)	1.99734709
62	Anencephaly (HP:0002323)	1.99369108
63	Hypothermia (HP:0002045)	1.98812073
64	Large for gestational age (HP:0001520)	1.98518297
65	Congenital primary aphakia (HP:0007707)	1.98475453
66	Renal Fanconi syndrome (HP:0001994)	1.98245233
67	Congenital hepatic fibrosis (HP:0002612)	1.97687354
68	Aplasia/Hypoplasia of the patella (HP:0006498)	1.96215425
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92593543
70	Chorioretinal atrophy (HP:0000533)	1.90433046
71	Gaze-evoked nystagmus (HP:0000640)	1.90384883
72	Type 2 muscle fiber atrophy (HP:0003554)	1.90120632
73	Progressive microcephaly (HP:0000253)	1.89090986
74	Abnormality of the ileum (HP:0001549)	1.88798851
75	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.87631592
76	Meckel diverticulum (HP:0002245)	1.87296600
77	Nephrogenic diabetes insipidus (HP:0009806)	1.87274587
78	Furrowed tongue (HP:0000221)	1.86581787
79	Type I transferrin isoform profile (HP:0003642)	1.85836822
80	Absent/shortened dynein arms (HP:0200106)	1.85033430
81	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.85033430
82	Broad-based gait (HP:0002136)	1.81467617
83	Lissencephaly (HP:0001339)	1.80399276
84	Small hand (HP:0200055)	1.79896505
85	Abnormal protein glycosylation (HP:0012346)	1.79587220
86	Abnormal glycosylation (HP:0012345)	1.79587220
87	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.79587220
88	Abnormal protein N-linked glycosylation (HP:0012347)	1.79587220
89	Lactic acidosis (HP:0003128)	1.78652567
90	Decreased circulating renin level (HP:0003351)	1.77620832
91	Male pseudohermaphroditism (HP:0000037)	1.77113239
92	Ketosis (HP:0001946)	1.76244107
93	Cerebellar dysplasia (HP:0007033)	1.75076536
94	Cerebral edema (HP:0002181)	1.74884523
95	Severe muscular hypotonia (HP:0006829)	1.72968653
96	IgG deficiency (HP:0004315)	1.72234765
97	Exertional dyspnea (HP:0002875)	1.72012394
98	Postaxial foot polydactyly (HP:0001830)	1.71565753
99	Clubbing of toes (HP:0100760)	1.70696684
100	Abnormality of vitamin B metabolism (HP:0004340)	1.70379046

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.83816338
2	BMPR1B	3.24766562
3	TLK1	3.23445083
4	ADRBK2	3.12819138
5	ZAK	3.02802180
6	MAP4K2	2.65667823
7	NUAK1	2.63365750
8	TAOK3	2.51933920
9	ACVR1B	2.47838356
10	GRK1	2.44818037
11	WNK4	2.43546833
12	WNK3	2.35544559
13	TXK	1.99397698
14	BCKDK	1.69593009
15	INSRR	1.69102263
16	OXSR1	1.62120446
17	TRIM28	1.59172106
18	VRK2	1.56740309
19	MAPK13	1.53756652
20	PINK1	1.52775280
21	MKNK2	1.46952181
22	VRK1	1.39956719
23	MAP3K4	1.35232812
24	STK39	1.27209297
25	MAPK15	1.26580486
26	CAMKK2	1.24741572
27	DYRK2	1.19885720
28	CASK	1.15890652
29	DAPK2	1.15576293
30	ADRBK1	1.14812234
31	MST4	1.14293899
32	STK16	1.13427210
33	MUSK	0.99997113
34	BRSK2	0.98747988
35	TNIK	0.94501836
36	IKBKB	0.92587295
37	PAK3	0.91821371
38	TGFBR1	0.89538906
39	CSNK1G1	0.89429448
40	PHKG2	0.87958318
41	PHKG1	0.87958318
42	PLK4	0.86252700
43	TAF1	0.85396977
44	CSNK1G2	0.82469379
45	NEK2	0.82320778
46	CSNK1G3	0.78661237
47	MAP2K7	0.78056671
48	PRKCG	0.74914867
49	PDK2	0.74856247
50	MKNK1	0.74701295
51	PLK3	0.74437108
52	BUB1	0.73699308
53	PRKCE	0.73206971
54	KIT	0.69959232
55	CSNK1A1L	0.69635135
56	MAP2K6	0.68310764
57	CCNB1	0.67804102
58	TIE1	0.65708332
59	TEC	0.64978578
60	PLK2	0.64179203
61	PNCK	0.63591135
62	CHUK	0.61230681
63	MARK1	0.58540247
64	CDC7	0.57039004
65	TSSK6	0.57019935
66	SYK	0.55619357
67	PRKCI	0.55308629
68	ERBB3	0.55016771
69	RPS6KA5	0.54750684
70	SRPK1	0.53827849
71	NME1	0.52823736
72	MAPKAPK3	0.52382025
73	ATR	0.51231182
74	IKBKE	0.51220343
75	PRKCQ	0.49986585
76	CHEK2	0.49567165
77	GRK6	0.49506016
78	NLK	0.47955410
79	PTK2B	0.47656330
80	OBSCN	0.47613415
81	WEE1	0.46943050
82	GRK7	0.45972351
83	PIK3CA	0.45414200
84	MAPKAPK5	0.44848259
85	DYRK3	0.43241330
86	GRK5	0.42926016
87	PLK1	0.42673597
88	STK11	0.42632478
89	EIF2AK3	0.41562283
90	ITK	0.40890074
91	PRKACA	0.40615452
92	NTRK3	0.40204957
93	CAMK1	0.39311836
94	PKN1	0.38531195
95	CSNK1D	0.37917546
96	CSNK1A1	0.37145213
97	TNK2	0.36244796
98	CAMK1D	0.35442519
99	FLT3	0.34583656
100	BCR	0.33363560

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.00921960
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.63007515
3	Homologous recombination_Homo sapiens_hsa03440	2.56664259
4	RNA polymerase_Homo sapiens_hsa03020	2.51379036
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.43751997
6	Phototransduction_Homo sapiens_hsa04744	2.40872450
7	Parkinsons disease_Homo sapiens_hsa05012	2.39637970
8	Protein export_Homo sapiens_hsa03060	2.16973964
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.11671765
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.09850123
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.09133069
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.03811237
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.95685306
14	Basal transcription factors_Homo sapiens_hsa03022	1.93821725
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.92675973
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.87393828
17	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.85238596
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.81896439
19	Proteasome_Homo sapiens_hsa03050	1.78879404
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.68367095
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.66187097
22	Butanoate metabolism_Homo sapiens_hsa00650	1.64101333
23	Huntingtons disease_Homo sapiens_hsa05016	1.61632250
24	RNA degradation_Homo sapiens_hsa03018	1.58893056
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.57841405
26	One carbon pool by folate_Homo sapiens_hsa00670	1.57612377
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56117656
28	Nicotine addiction_Homo sapiens_hsa05033	1.53959659
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.53054671
30	Ribosome_Homo sapiens_hsa03010	1.45114311
31	Alzheimers disease_Homo sapiens_hsa05010	1.41941747
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.38228641
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38103117
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.29527326
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.29207808
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26971282
37	Caffeine metabolism_Homo sapiens_hsa00232	1.26267508
38	Primary immunodeficiency_Homo sapiens_hsa05340	1.24841929
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.21733987
40	Propanoate metabolism_Homo sapiens_hsa00640	1.20445728
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.19620979
42	Asthma_Homo sapiens_hsa05310	1.11696073
43	Regulation of autophagy_Homo sapiens_hsa04140	1.11442961
44	Taste transduction_Homo sapiens_hsa04742	1.10021193
45	Non-homologous end-joining_Homo sapiens_hsa03450	1.09035615
46	Sulfur relay system_Homo sapiens_hsa04122	1.02010795
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.99461348
48	Peroxisome_Homo sapiens_hsa04146	0.99355532
49	Purine metabolism_Homo sapiens_hsa00230	0.95799873
50	Morphine addiction_Homo sapiens_hsa05032	0.94886903
51	Olfactory transduction_Homo sapiens_hsa04740	0.94238940
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.94144793
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91508338
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88302291
55	Type I diabetes mellitus_Homo sapiens_hsa04940	0.85980249
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82711985
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79392860
58	Mismatch repair_Homo sapiens_hsa03430	0.79231456
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78709998
60	Graft-versus-host disease_Homo sapiens_hsa05332	0.78096622
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76984603
62	Base excision repair_Homo sapiens_hsa03410	0.74818271
63	Allograft rejection_Homo sapiens_hsa05330	0.73835603
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72925264
65	Retinol metabolism_Homo sapiens_hsa00830	0.71960732
66	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.69262331
67	Metabolic pathways_Homo sapiens_hsa01100	0.67036068
68	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66558085
69	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.65560762
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.64195066
71	Serotonergic synapse_Homo sapiens_hsa04726	0.63486764
72	RNA transport_Homo sapiens_hsa03013	0.61414907
73	GABAergic synapse_Homo sapiens_hsa04727	0.57727406
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.57603357
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57513155
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57223984
77	Circadian rhythm_Homo sapiens_hsa04710	0.55700674
78	ABC transporters_Homo sapiens_hsa02010	0.55634905
79	Insulin secretion_Homo sapiens_hsa04911	0.54895212
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54629317
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53683896
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52464551
83	Sulfur metabolism_Homo sapiens_hsa00920	0.51875123
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51820686
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49560261
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.48626820
87	Circadian entrainment_Homo sapiens_hsa04713	0.48199045
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47287434
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.46712535
90	Glutamatergic synapse_Homo sapiens_hsa04724	0.45928737
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.43864614
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43312801
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42639058
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.41682693
95	Mineral absorption_Homo sapiens_hsa04978	0.41576377
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40118124
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39000979
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38367512
99	DNA replication_Homo sapiens_hsa03030	0.34088522
100	Spliceosome_Homo sapiens_hsa03040	0.31820319

P2RX5-TAX1BP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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