ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	5.58172976
2	negative regulation of thymocyte apoptotic process (GO:0070244)	5.47206617
3	protein neddylation (GO:0045116)	4.96491055
4	thrombin receptor signaling pathway (GO:0070493)	4.92643682
5	grooming behavior (GO:0007625)	4.90167775
6	regulation of female receptivity (GO:0045924)	4.48270439
7	fusion of sperm to egg plasma membrane (GO:0007342)	4.29889165
8	purine nucleotide salvage (GO:0032261)	4.24832847
9	purinergic nucleotide receptor signaling pathway (GO:0035590)	4.24144015
10	sleep (GO:0030431)	4.23905158
11	aggressive behavior (GO:0002118)	4.23563365
12	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.20526173
13	regulation of penile erection (GO:0060405)	4.18576628
14	GMP metabolic process (GO:0046037)	4.09860426
15	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.88113757
16	regulation of sensory perception (GO:0051931)	3.82729538
17	regulation of sensory perception of pain (GO:0051930)	3.82729538
18	negative regulation of heart rate (GO:0010459)	3.77519097
19	female mating behavior (GO:0060180)	3.67198710
20	plasma membrane fusion (GO:0045026)	3.63617951
21	positive regulation of glycolytic process (GO:0045821)	3.60304842
22	relaxation of smooth muscle (GO:0044557)	3.45954656
23	regulation of macrophage derived foam cell differentiation (GO:0010743)	3.44504321
24	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	3.43080666
25	negative regulation of calcium ion transmembrane transport (GO:1903170)	3.43080666
26	purine-containing compound salvage (GO:0043101)	3.41848684
27	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.39315113
28	response to gravity (GO:0009629)	3.37891745
29	maternal behavior (GO:0042711)	3.37011443
30	regulation of cilium movement (GO:0003352)	3.33438347
31	negative regulation of T cell apoptotic process (GO:0070233)	3.26707266
32	purinergic receptor signaling pathway (GO:0035587)	3.26076179
33	parental behavior (GO:0060746)	3.24283898
34	regulation of integrin-mediated signaling pathway (GO:2001044)	3.22362136
35	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.21516766
36	hyperosmotic salinity response (GO:0042538)	3.21344838
37	lipoxygenase pathway (GO:0019372)	3.20090447
38	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.17600819
39	L-phenylalanine catabolic process (GO:0006559)	3.17600819
40	regulation of skeletal muscle contraction (GO:0014819)	3.15574613
41	regulation of catecholamine metabolic process (GO:0042069)	3.14560682
42	regulation of dopamine metabolic process (GO:0042053)	3.14560682
43	single strand break repair (GO:0000012)	3.09541909
44	regulation of platelet aggregation (GO:0090330)	3.07203695
45	regulation of platelet activation (GO:0010543)	3.05577371
46	adenosine metabolic process (GO:0046085)	3.04611886
47	regulation of thymocyte apoptotic process (GO:0070243)	3.01848684
48	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.97184878
49	blood coagulation, intrinsic pathway (GO:0007597)	2.92446638
50	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.90786674
51	branched-chain amino acid catabolic process (GO:0009083)	2.89924825
52	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.89561773
53	mitochondrial calcium ion homeostasis (GO:0051560)	2.86853008
54	L-phenylalanine metabolic process (GO:0006558)	2.86459075
55	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.86459075
56	dopamine transport (GO:0015872)	2.85555888
57	regulation of megakaryocyte differentiation (GO:0045652)	2.79577374
58	negative regulation of response to food (GO:0032096)	2.79297458
59	negative regulation of appetite (GO:0032099)	2.79297458
60	cardiolipin metabolic process (GO:0032048)	2.78610838
61	regulation of norepinephrine secretion (GO:0014061)	2.77866631
62	polyamine biosynthetic process (GO:0006596)	2.76744292
63	regulation of uterine smooth muscle contraction (GO:0070472)	2.76195377
64	branched-chain amino acid metabolic process (GO:0009081)	2.72758954
65	mitochondrial calcium ion transport (GO:0006851)	2.72663189
66	positive regulation of macrophage differentiation (GO:0045651)	2.71716344
67	regulation of lipoprotein metabolic process (GO:0050746)	2.71470768
68	positive regulation of endothelial cell differentiation (GO:0045603)	2.71331390
69	platelet dense granule organization (GO:0060155)	2.71009753
70	regulation of relaxation of muscle (GO:1901077)	2.70636985
71	negative regulation of cation channel activity (GO:2001258)	2.70014689
72	ether lipid metabolic process (GO:0046485)	2.69275737
73	regulation of cholesterol efflux (GO:0010874)	2.67071434
74	microtubule depolymerization (GO:0007019)	2.66949577
75	DNA deamination (GO:0045006)	2.61890064
76	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.61528427
77	negative regulation of membrane potential (GO:0045837)	2.61514812
78	regulation of Golgi to plasma membrane protein transport (GO:0042996)	2.61358201
79	positive regulation of granulocyte differentiation (GO:0030854)	2.60450447
80	negative regulation of platelet activation (GO:0010544)	2.59371782
81	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.59171028
82	negative regulation of T-helper cell differentiation (GO:0045623)	2.59171028
83	cellular ketone body metabolic process (GO:0046950)	2.58410311
84	monoamine transport (GO:0015844)	2.55678851
85	neutrophil activation involved in immune response (GO:0002283)	2.55456614
86	sulfation (GO:0051923)	2.53254284
87	high-density lipoprotein particle remodeling (GO:0034375)	2.52869403
88	regulation of memory T cell differentiation (GO:0043380)	2.52475171
89	glucosamine-containing compound catabolic process (GO:1901072)	2.52402651
90	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.52102185
91	male meiosis (GO:0007140)	2.50435115
92	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.50424439
93	deoxyribose phosphate biosynthetic process (GO:0046385)	2.50424439
94	cell wall macromolecule metabolic process (GO:0044036)	2.49474541
95	termination of G-protein coupled receptor signaling pathway (GO:0038032)	2.49095506
96	activated T cell proliferation (GO:0050798)	2.48816236
97	multicellular organism reproduction (GO:0032504)	2.48801312
98	neuronal action potential propagation (GO:0019227)	2.48087792
99	behavioral response to nicotine (GO:0035095)	2.47288386
100	low-density lipoprotein particle remodeling (GO:0034374)	2.46810771

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.67459134
2	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.87325413
3	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	3.85473898
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.98582384
5	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.71864371
6	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.25198548
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.20440294
8	GATA1_22025678_ChIP-Seq_K562_Human	2.11947572
9	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	2.10256251
10	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.05573313
11	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.95748408
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95671700
13	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.95670017
14	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.93156213
15	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.82019974
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.79235196
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.76979320
18	HTT_18923047_ChIP-ChIP_STHdh_Human	1.74399270
19	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.73893794
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.68855393
21	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.66255550
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.66150670
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62267249
24	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.61048496
25	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.56429083
26	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.56429083
27	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.56001927
28	AR_20517297_ChIP-Seq_VCAP_Human	1.55743041
29	STAT1_20625510_ChIP-Seq_HELA_Human	1.51367745
30	SOX2_19829295_ChIP-Seq_ESCs_Human	1.50810520
31	NANOG_19829295_ChIP-Seq_ESCs_Human	1.50810520
32	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.48547894
33	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.44960082
34	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.39552277
35	EWS_26573619_Chip-Seq_HEK293_Human	1.38594128
36	ZNF274_21170338_ChIP-Seq_K562_Hela	1.34223734
37	FUS_26573619_Chip-Seq_HEK293_Human	1.29805189
38	GATA3_26560356_Chip-Seq_TH2_Human	1.28815591
39	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.27392690
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.26969899
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.26242514
42	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.25514104
43	MYC_19829295_ChIP-Seq_ESCs_Human	1.25393382
44	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.24070433
45	RBPJ_21746931_ChIP-Seq_IB4_Human	1.22607040
46	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.21112162
47	SCL_19346495_ChIP-Seq_HPC-7_Human	1.21072578
48	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.19923721
49	AR_25329375_ChIP-Seq_VCAP_Human	1.19443063
50	VDR_22108803_ChIP-Seq_LS180_Human	1.19320655
51	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.19076485
52	CDX2_22108803_ChIP-Seq_LS180_Human	1.18461645
53	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.16501461
54	PHF8_20622853_ChIP-Seq_HELA_Human	1.15202403
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15066341
56	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14718112
57	GATA1_19941826_ChIP-Seq_K562_Human	1.14349789
58	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.13193299
59	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.13187503
60	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.12381443
61	EZH2_22144423_ChIP-Seq_EOC_Human	1.11306020
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.10378078
63	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.09739503
64	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09426420
65	GATA2_19941826_ChIP-Seq_K562_Human	1.09298755
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09277717
67	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.09136714
68	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.08945953
69	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08753619
70	STAT1_17558387_ChIP-Seq_HELA_Human	1.08289898
71	ZNF263_19887448_ChIP-Seq_K562_Human	1.07868363
72	BCL6_27268052_Chip-Seq_Bcells_Human	1.07694671
73	MYB_26560356_Chip-Seq_TH2_Human	1.06823956
74	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.05681660
75	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.05206710
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04607292
77	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.03751179
78	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.03643522
79	P300_19829295_ChIP-Seq_ESCs_Human	1.02965724
80	ERG_20517297_ChIP-Seq_VCAP_Human	1.02677804
81	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02584907
82	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01310859
83	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.00034047
84	CBP_20019798_ChIP-Seq_JUKART_Human	0.99631294
85	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.99631294
86	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.99324916
87	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.98746928
88	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.98510121
89	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.97919189
90	CEBPB_22108803_ChIP-Seq_LS180_Human	0.96951817
91	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.96582652
92	NFYB_21822215_ChIP-Seq_K562_Human	0.95978205
93	GATA3_26560356_Chip-Seq_TH1_Human	0.95807723
94	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.94508413
95	STAT3_23295773_ChIP-Seq_U87_Human	0.94471304
96	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.93380204
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93355000
98	SMRT_27268052_Chip-Seq_Bcells_Human	0.92657642
99	VDR_23849224_ChIP-Seq_CD4+_Human	0.91857294
100	RNF2_27304074_Chip-Seq_NSC_Mouse	0.90728560

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005464_abnormal_platelet_physiology	4.77772903
2	MP0005646_abnormal_pituitary_gland	3.65630943
3	MP0003724_increased_susceptibility_to	2.99093178
4	MP0003806_abnormal_nucleotide_metabolis	2.67619621
5	MP0008004_abnormal_stomach_pH	2.61205847
6	MP0003646_muscle_fatigue	2.59208100
7	MP0005084_abnormal_gallbladder_morpholo	2.53591018
8	MP0006036_abnormal_mitochondrial_physio	2.46589580
9	MP0009697_abnormal_copulation	2.36530574
10	MP0005410_abnormal_fertilization	2.34983319
11	MP0008877_abnormal_DNA_methylation	2.22269149
12	MP0008872_abnormal_physiological_respon	2.20151076
13	MP0000372_irregular_coat_pigmentation	2.16461525
14	MP0000230_abnormal_systemic_arterial	2.12982752
15	MP0000465_gastrointestinal_hemorrhage	2.11559913
16	MP0002132_abnormal_respiratory_system	2.04774441
17	MP0001661_extended_life_span	2.03194839
18	MP0005083_abnormal_biliary_tract	2.02573958
19	MP0004084_abnormal_cardiac_muscle	1.87322058
20	MP0004036_abnormal_muscle_relaxation	1.85992339
21	MP0003186_abnormal_redox_activity	1.83750537
22	MP0006276_abnormal_autonomic_nervous	1.83326726
23	MP0010386_abnormal_urinary_bladder	1.73747209
24	MP0003787_abnormal_imprinting	1.73119805
25	MP0004215_abnormal_myocardial_fiber	1.71108540
26	MP0002102_abnormal_ear_morphology	1.63829310
27	MP0002736_abnormal_nociception_after	1.63104042
28	MP0004145_abnormal_muscle_electrophysio	1.52852023
29	MP0003195_calcinosis	1.51452335
30	MP0002876_abnormal_thyroid_physiology	1.48708466
31	MP0000343_altered_response_to	1.48358358
32	MP0008775_abnormal_heart_ventricle	1.47876846
33	MP0002148_abnormal_hypersensitivity_rea	1.47687305
34	MP0003879_abnormal_hair_cell	1.46257820
35	MP0009764_decreased_sensitivity_to	1.42562450
36	MP0002837_dystrophic_cardiac_calcinosis	1.41288564
37	MP0001764_abnormal_homeostasis	1.36550750
38	MP0003718_maternal_effect	1.36532610
39	MP0003252_abnormal_bile_duct	1.34563253
40	MP0002733_abnormal_thermal_nociception	1.30146362
41	MP0004147_increased_porphyrin_level	1.29622088
42	MP0006035_abnormal_mitochondrial_morpho	1.25018111
43	MP0001968_abnormal_touch/_nociception	1.22806534
44	MP0003828_pulmonary_edema	1.22430101
45	MP0003638_abnormal_response/metabolism_	1.20643828
46	MP0005535_abnormal_body_temperature	1.20609373
47	MP0001501_abnormal_sleep_pattern	1.16853562
48	MP0003136_yellow_coat_color	1.16689611
49	MP0004134_abnormal_chest_morphology	1.16664944
50	MP0005332_abnormal_amino_acid	1.16560242
51	MP0003866_abnormal_defecation	1.15880891
52	MP0001756_abnormal_urination	1.13311290
53	MP0010329_abnormal_lipoprotein_level	1.11793048
54	MP0001440_abnormal_grooming_behavior	1.09960713
55	MP0001970_abnormal_pain_threshold	1.09010895
56	MP0001542_abnormal_bone_strength	1.07974165
57	MP0004130_abnormal_muscle_cell	1.07785567
58	MP0005385_cardiovascular_system_phenoty	1.06640733
59	MP0001544_abnormal_cardiovascular_syste	1.06640733
60	MP0002234_abnormal_pharynx_morphology	1.06166889
61	MP0000749_muscle_degeneration	1.06121034
62	MP0005000_abnormal_immune_tolerance	1.01224802
63	MP0005647_abnormal_sex_gland	0.97902320
64	MP0001765_abnormal_ion_homeostasis	0.97483750
65	MP0010155_abnormal_intestine_physiology	0.95419873
66	MP0001879_abnormal_lymphatic_vessel	0.95317518
67	MP0001663_abnormal_digestive_system	0.94354791
68	MP0005620_abnormal_muscle_contractility	0.94111787
69	MP0001905_abnormal_dopamine_level	0.94107717
70	MP0002735_abnormal_chemical_nociception	0.91625680
71	MP0002928_abnormal_bile_duct	0.90828262
72	MP0010368_abnormal_lymphatic_system	0.90602621
73	MP0003880_abnormal_central_pattern	0.89600762
74	MP0005551_abnormal_eye_electrophysiolog	0.89571885
75	MP0002272_abnormal_nervous_system	0.88589102
76	MP0009765_abnormal_xenobiotic_induced	0.88477748
77	MP0009046_muscle_twitch	0.86866552
78	MP0005670_abnormal_white_adipose	0.86822797
79	MP0002118_abnormal_lipid_homeostasis	0.85125603
80	MP0004142_abnormal_muscle_tone	0.85119017
81	MP0001664_abnormal_digestion	0.84267768
82	MP0003075_altered_response_to	0.82885957
83	MP0005165_increased_susceptibility_to	0.80777499
84	MP0009643_abnormal_urine_homeostasis	0.80706662
85	MP0005645_abnormal_hypothalamus_physiol	0.80456729
86	MP0003436_decreased_susceptibility_to	0.78714156
87	MP0008875_abnormal_xenobiotic_pharmacok	0.75196683
88	MP0002106_abnormal_muscle_physiology	0.74240628
89	MP0005448_abnormal_energy_balance	0.73825466
90	MP0002972_abnormal_cardiac_muscle	0.73603213
91	MP0003698_abnormal_male_reproductive	0.73517677
92	MP0004233_abnormal_muscle_weight	0.71462550
93	MP0004947_skin_inflammation	0.71267704
94	MP0003656_abnormal_erythrocyte_physiolo	0.69453868
95	MP0005319_abnormal_enzyme/_coenzyme	0.69332737
96	MP0005369_muscle_phenotype	0.68426176
97	MP0009642_abnormal_blood_homeostasis	0.68391138
98	MP0005266_abnormal_metabolism	0.67586333
99	MP0001502_abnormal_circadian_rhythm	0.66984439
100	MP0000013_abnormal_adipose_tissue	0.66310152

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged bleeding time (HP:0003010)	5.64720104
2	Petechiae (HP:0000967)	5.25312153
3	Menorrhagia (HP:0000132)	4.85864657
4	Increased mean platelet volume (HP:0011877)	4.80179972
5	Abnormal platelet volume (HP:0011876)	4.47295922
6	Dyschromatopsia (HP:0007641)	4.39786010
7	Nemaline bodies (HP:0003798)	4.00321031
8	Decreased central vision (HP:0007663)	3.93615675
9	Hyperlipoproteinemia (HP:0010980)	3.76245377
10	Purpura (HP:0000979)	3.67822500
11	Muscle fiber inclusion bodies (HP:0100299)	3.60323699
12	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.53951607
13	Acute necrotizing encephalopathy (HP:0006965)	3.49293495
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.37176501
15	Epistaxis (HP:0000421)	3.32488163
16	Muscle fiber splitting (HP:0003555)	3.10891961
17	Acute encephalopathy (HP:0006846)	3.08413295
18	Progressive macrocephaly (HP:0004481)	3.02613100
19	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.91006931
20	Mitochondrial inheritance (HP:0001427)	2.88454199
21	Muscle hypertrophy of the lower extremities (HP:0008968)	2.85814604
22	Calf muscle hypertrophy (HP:0008981)	2.82267047
23	Testicular atrophy (HP:0000029)	2.73530044
24	Hepatic necrosis (HP:0002605)	2.65954369
25	Hypothermia (HP:0002045)	2.64375376
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.64041035
27	Abnormal pupillary function (HP:0007686)	2.63391164
28	Myoglobinuria (HP:0002913)	2.59973127
29	Stomatitis (HP:0010280)	2.56882555
30	Facial diplegia (HP:0001349)	2.54247549
31	Hyperglycinuria (HP:0003108)	2.51196560
32	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.48239843
33	Abnormal protein N-linked glycosylation (HP:0012347)	2.48239843
34	Abnormal protein glycosylation (HP:0012346)	2.48239843
35	Abnormal glycosylation (HP:0012345)	2.48239843
36	Central scotoma (HP:0000603)	2.43684482
37	Cerebral edema (HP:0002181)	2.41833937
38	Renal Fanconi syndrome (HP:0001994)	2.39501714
39	Rimmed vacuoles (HP:0003805)	2.36716367
40	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.35339331
41	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.35339331
42	Hepatocellular necrosis (HP:0001404)	2.30174589
43	Increased intramyocellular lipid droplets (HP:0012240)	2.27581620
44	Increased CSF lactate (HP:0002490)	2.26335658
45	Ketoacidosis (HP:0001993)	2.26193673
46	Gingival bleeding (HP:0000225)	2.25648020
47	Abnormal rod and cone electroretinograms (HP:0008323)	2.24550800
48	Abnormal ciliary motility (HP:0012262)	2.22588194
49	Abnormality of macular pigmentation (HP:0008002)	2.16499690
50	Abnormality of the costochondral junction (HP:0000919)	2.15875204
51	Paralysis (HP:0003470)	2.14969200
52	Tongue fasciculations (HP:0001308)	2.13556942
53	Generalized aminoaciduria (HP:0002909)	2.13350373
54	Abnormal platelet function (HP:0011869)	2.12242954
55	Impaired platelet aggregation (HP:0003540)	2.12242954
56	Attenuation of retinal blood vessels (HP:0007843)	2.10402818
57	Abnormal auditory evoked potentials (HP:0006958)	2.08527111
58	Metaphyseal dysplasia (HP:0100255)	2.04843264
59	Weak cry (HP:0001612)	2.02040868
60	Shoulder girdle muscle weakness (HP:0003547)	2.01419325
61	Intellectual disability, profound (HP:0002187)	2.01320929
62	Ulnar deviation of the wrist (HP:0003049)	2.00840953
63	Increased muscle lipid content (HP:0009058)	2.00258018
64	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.98542959
65	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.98542959
66	Anhidrosis (HP:0000970)	1.98304794
67	Abnormal respiratory epithelium morphology (HP:0012253)	1.97447641
68	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97447641
69	Pancreatic cysts (HP:0001737)	1.97256602
70	Distal lower limb amyotrophy (HP:0008944)	1.95674114
71	Type 2 muscle fiber atrophy (HP:0003554)	1.95114059
72	Alveolar cell carcinoma (HP:0006519)	1.93970277
73	Ketosis (HP:0001946)	1.93858649
74	Tinnitus (HP:0000360)	1.92982289
75	Reduced antithrombin III activity (HP:0001976)	1.91440565
76	Abnormality of glycine metabolism (HP:0010895)	1.89271134
77	Abnormality of serine family amino acid metabolism (HP:0010894)	1.89271134
78	Difficulty climbing stairs (HP:0003551)	1.89072476
79	Type I transferrin isoform profile (HP:0003642)	1.88827709
80	Rhabdomyolysis (HP:0003201)	1.88289059
81	Keratoconus (HP:0000563)	1.87861662
82	Increased corneal curvature (HP:0100692)	1.87861662
83	Glucose intolerance (HP:0000833)	1.87822765
84	Insulin-resistant diabetes mellitus (HP:0000831)	1.87419167
85	Polydipsia (HP:0001959)	1.86346055
86	Abnormal drinking behavior (HP:0030082)	1.86346055
87	Areflexia of lower limbs (HP:0002522)	1.86264718
88	Exercise-induced myalgia (HP:0003738)	1.86131053
89	Scotoma (HP:0000575)	1.82866426
90	Optic disc pallor (HP:0000543)	1.81705074
91	Lethargy (HP:0001254)	1.81650732
92	Pelvic girdle muscle weakness (HP:0003749)	1.81615573
93	Respiratory failure (HP:0002878)	1.81316064
94	Abnormality of the corticospinal tract (HP:0002492)	1.80727897
95	Distal arthrogryposis (HP:0005684)	1.80420975
96	Muscle fibrillation (HP:0010546)	1.77032364
97	Exertional dyspnea (HP:0002875)	1.76579320
98	Mitral stenosis (HP:0001718)	1.76163466
99	Lactic acidosis (HP:0003128)	1.75344986
100	Abnormality of the renal cortex (HP:0011035)	1.74941062

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.00848318
2	MAP3K14	3.17736946
3	TLK1	2.86265094
4	MAP4K2	2.81140711
5	MAPKAPK3	2.41828652
6	MAP3K13	2.25365609
7	BCKDK	2.15508927
8	EIF2AK3	2.12978615
9	TBK1	2.10223348
10	MYLK	2.04847312
11	IKBKB	2.02247941
12	IRAK1	1.97013560
13	SCYL2	1.96354129
14	OBSCN	1.92407466
15	STK16	1.87761096
16	PIK3CG	1.83398893
17	MAP2K7	1.80553264
18	IRAK2	1.79585025
19	IKBKE	1.77997042
20	BMPR2	1.67767843
21	FRK	1.63588351
22	TEC	1.60862726
23	DAPK2	1.60626954
24	EIF2AK2	1.59394460
25	BMX	1.57368868
26	GRK5	1.54347206
27	EIF2AK1	1.49884291
28	PTK2B	1.48315491
29	PHKG2	1.43509788
30	PHKG1	1.43509788
31	ZAK	1.41950915
32	MST4	1.38884155
33	FLT3	1.33864673
34	MAP3K12	1.30455155
35	CAMKK2	1.20709218
36	MAP3K6	1.19145977
37	STK39	1.15096099
38	ADRBK1	1.06945221
39	ADRBK2	1.06844851
40	PIK3CA	1.02933348
41	TNK2	0.99737139
42	PINK1	0.98010729
43	MAP3K7	0.97393746
44	PLK2	0.95880947
45	BTK	0.94851726
46	RIPK4	0.91056754
47	ITK	0.90768939
48	ZAP70	0.89966415
49	DAPK3	0.88899555
50	NUAK1	0.87587980
51	MAP2K1	0.86254219
52	ILK	0.83201926
53	LMTK2	0.81727988
54	VRK2	0.79242414
55	IRAK4	0.77622044
56	SYK	0.76017744
57	ABL2	0.75740971
58	MAP2K2	0.74940146
59	CSNK1G2	0.74069300
60	CHUK	0.71257789
61	NTRK3	0.70982799
62	BRSK2	0.70787423
63	OXSR1	0.69441961
64	MAPK13	0.67795319
65	CSF1R	0.64826433
66	TIE1	0.63325876
67	TXK	0.61986482
68	VRK1	0.61376033
69	WNK4	0.60028313
70	TAF1	0.59697111
71	MAP3K5	0.59554082
72	PLK3	0.57341899
73	MAP3K2	0.57317721
74	RPS6KA5	0.56943065
75	EPHB2	0.56294365
76	DAPK1	0.55421166
77	FES	0.55175078
78	CDK19	0.54630389
79	CSNK1G3	0.54343641
80	KDR	0.53838295
81	PAK3	0.53678523
82	GRK1	0.53473775
83	NEK1	0.52362370
84	TNIK	0.49405670
85	TRPM7	0.48757298
86	BMPR1B	0.47792384
87	RET	0.46680910
88	PRKCQ	0.45689671
89	EPHA4	0.45550465
90	CAMK1	0.43425897
91	GRK6	0.43137823
92	NME1	0.42250727
93	MAP3K4	0.41218663
94	EPHA3	0.40903553
95	PBK	0.40716563
96	MUSK	0.40404081
97	ABL1	0.38526564
98	MINK1	0.37869238
99	CSNK1G1	0.37671249
100	FER	0.37523410

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur metabolism_Homo sapiens_hsa00920	3.12274832
2	Phototransduction_Homo sapiens_hsa04744	3.02992387
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.94654714
4	Collecting duct acid secretion_Homo sapiens_hsa04966	2.91109738
5	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.81473052
6	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.65006649
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.62278364
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.28074472
9	Platelet activation_Homo sapiens_hsa04611	2.25232045
10	Protein export_Homo sapiens_hsa03060	2.19512462
11	Parkinsons disease_Homo sapiens_hsa05012	2.16025262
12	Proteasome_Homo sapiens_hsa03050	1.96878827
13	Butanoate metabolism_Homo sapiens_hsa00650	1.96586163
14	Regulation of autophagy_Homo sapiens_hsa04140	1.90299725
15	Fatty acid elongation_Homo sapiens_hsa00062	1.87862140
16	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.78579940
17	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.61192820
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.59364305
19	Peroxisome_Homo sapiens_hsa04146	1.53612683
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.52208345
21	Olfactory transduction_Homo sapiens_hsa04740	1.48261073
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.44256075
23	Propanoate metabolism_Homo sapiens_hsa00640	1.39300402
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.39021267
25	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.37823479
26	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.37233620
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.35692889
28	Alzheimers disease_Homo sapiens_hsa05010	1.32660089
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.32422643
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.32212246
31	Serotonergic synapse_Homo sapiens_hsa04726	1.31916959
32	Allograft rejection_Homo sapiens_hsa05330	1.30827097
33	One carbon pool by folate_Homo sapiens_hsa00670	1.29494236
34	Shigellosis_Homo sapiens_hsa05131	1.29105119
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.22873648
36	Purine metabolism_Homo sapiens_hsa00230	1.21953788
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.21476911
38	Type I diabetes mellitus_Homo sapiens_hsa04940	1.17572254
39	Calcium signaling pathway_Homo sapiens_hsa04020	1.15636339
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.15212621
41	Glycerolipid metabolism_Homo sapiens_hsa00561	1.10659366
42	Asthma_Homo sapiens_hsa05310	1.09423784
43	Graft-versus-host disease_Homo sapiens_hsa05332	1.09135475
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.08298347
45	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.08237357
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06311392
47	Alcoholism_Homo sapiens_hsa05034	1.05446750
48	Arginine and proline metabolism_Homo sapiens_hsa00330	1.02766439
49	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.96370846
50	Huntingtons disease_Homo sapiens_hsa05016	0.95833639
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95602825
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94936944
53	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.94691099
54	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.92761805
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.91197167
56	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.90116837
57	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.89266668
58	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.89090586
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86486267
60	Tyrosine metabolism_Homo sapiens_hsa00350	0.79483006
61	Glutathione metabolism_Homo sapiens_hsa00480	0.78562864
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.78176028
63	Circadian entrainment_Homo sapiens_hsa04713	0.76645096
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75190570
65	Circadian rhythm_Homo sapiens_hsa04710	0.72506087
66	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.71282153
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.71181308
68	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70702828
69	Morphine addiction_Homo sapiens_hsa05032	0.70436287
70	Taste transduction_Homo sapiens_hsa04742	0.65787424
71	Salivary secretion_Homo sapiens_hsa04970	0.65706620
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62175088
73	Pancreatic secretion_Homo sapiens_hsa04972	0.61274271
74	Legionellosis_Homo sapiens_hsa05134	0.59532297
75	Fatty acid degradation_Homo sapiens_hsa00071	0.55605712
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53365341
77	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.50317618
78	Metabolic pathways_Homo sapiens_hsa01100	0.48219680
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45434253
80	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.45117937
81	Insulin secretion_Homo sapiens_hsa04911	0.44617473
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43165325
83	ECM-receptor interaction_Homo sapiens_hsa04512	0.42628496
84	ABC transporters_Homo sapiens_hsa02010	0.42232853
85	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.39000333
86	Renin secretion_Homo sapiens_hsa04924	0.37401712
87	Endocytosis_Homo sapiens_hsa04144	0.37096332
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35038750
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33799097
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.32701688
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.31693971
92	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.28825090
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.28218809
94	Retinol metabolism_Homo sapiens_hsa00830	0.28062529
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.27699320
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.27184463
97	Antigen processing and presentation_Homo sapiens_hsa04612	0.26464801
98	Long-term depression_Homo sapiens_hsa04730	0.25892398
99	Ether lipid metabolism_Homo sapiens_hsa00565	0.25309757
100	Vibrio cholerae infection_Homo sapiens_hsa05110	0.24954339

P2RX6P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »