P2RY10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. There is a pseudogene for this gene nearby on chromosome X. Multiple alternatively spliced transcripts have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.46472205
2negative T cell selection (GO:0043383)6.43003366
3negative thymic T cell selection (GO:0045060)6.24298328
4positive regulation of gamma-delta T cell activation (GO:0046645)6.22953218
5positive thymic T cell selection (GO:0045059)6.21349650
6interferon-gamma production (GO:0032609)6.05247426
7thymic T cell selection (GO:0045061)5.71193491
8positive T cell selection (GO:0043368)5.69263433
9regulation of gamma-delta T cell differentiation (GO:0045586)5.68949000
10antigen processing and presentation of endogenous antigen (GO:0019883)5.47414650
11T cell selection (GO:0045058)5.46346550
12negative regulation of cell killing (GO:0031342)5.35182894
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.35182894
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.24883166
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.24883166
16regulation of gamma-delta T cell activation (GO:0046643)5.23962411
17tolerance induction (GO:0002507)5.22997423
18response to interleukin-15 (GO:0070672)5.12992498
19cellular response to interleukin-15 (GO:0071350)5.11115445
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.98279707
21NIK/NF-kappaB signaling (GO:0038061)4.86121686
22regulation of interleukin-12 biosynthetic process (GO:0045075)4.71381643
23regulation of B cell receptor signaling pathway (GO:0050855)4.62431078
24T cell receptor signaling pathway (GO:0050852)4.49586960
25T cell costimulation (GO:0031295)4.39201024
26regulation of T cell tolerance induction (GO:0002664)4.38323733
27regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.36899492
28regulation of T cell receptor signaling pathway (GO:0050856)4.36393845
29lymphocyte costimulation (GO:0031294)4.35763341
30antigen receptor-mediated signaling pathway (GO:0050851)4.21172274
31positive regulation of interleukin-2 production (GO:0032743)4.19182746
32T cell migration (GO:0072678)4.15253228
33regulation of isotype switching to IgG isotypes (GO:0048302)4.08338306
34regulation of regulatory T cell differentiation (GO:0045589)4.03494572
35B cell receptor signaling pathway (GO:0050853)4.03198444
36regulation of alpha-beta T cell proliferation (GO:0046640)3.97082605
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.95018812
38positive regulation by organism of defense response of other organism involved in symbiotic interact3.95018812
39modulation by symbiont of host immune response (GO:0052553)3.95018812
40positive regulation by symbiont of host defense response (GO:0052509)3.95018812
41modulation by symbiont of host defense response (GO:0052031)3.95018812
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.95018812
43cellular response to type I interferon (GO:0071357)3.91474810
44type I interferon signaling pathway (GO:0060337)3.91474810
45CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.88136027
46T-helper cell differentiation (GO:0042093)3.88136027
47response to type I interferon (GO:0034340)3.87757017
48CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.77635313
49immunoglobulin mediated immune response (GO:0016064)3.72844227
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.68676545
51regulation of interferon-beta biosynthetic process (GO:0045357)3.67213583
52B cell homeostasis (GO:0001782)3.65202680
53positive regulation of isotype switching (GO:0045830)3.62450828
54regulation of B cell differentiation (GO:0045577)3.62424481
55leukocyte aggregation (GO:0070486)3.60286478
56mature B cell differentiation (GO:0002335)3.60268025
57negative regulation of lymphocyte mediated immunity (GO:0002707)3.57327962
58positive regulation of alpha-beta T cell proliferation (GO:0046641)3.55367340
59regulation of interleukin-2 biosynthetic process (GO:0045076)3.54665307
60alpha-beta T cell activation (GO:0046631)3.53019782
61T cell differentiation involved in immune response (GO:0002292)3.47735129
62alpha-beta T cell differentiation involved in immune response (GO:0002293)3.47735129
63alpha-beta T cell activation involved in immune response (GO:0002287)3.47735129
64alpha-beta T cell differentiation (GO:0046632)3.47235687
65detection of bacterium (GO:0016045)3.43535323
66regulation of chronic inflammatory response (GO:0002676)3.43056811
67antigen processing and presentation via MHC class Ib (GO:0002475)3.42609845
68regulation of T cell mediated cytotoxicity (GO:0001914)3.39529162
69myeloid dendritic cell activation (GO:0001773)3.37670293
70B cell mediated immunity (GO:0019724)3.36500802
71positive regulation of B cell differentiation (GO:0045579)3.36321949
72detection of other organism (GO:0098543)3.34630147
73negative regulation of T cell mediated immunity (GO:0002710)3.33878028
74JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.32524633
75activated T cell proliferation (GO:0050798)3.31851994
76response to muramyl dipeptide (GO:0032495)3.31739962
77myeloid dendritic cell differentiation (GO:0043011)3.31607439
78positive regulation of T cell mediated cytotoxicity (GO:0001916)3.30837070
79regulation of hypersensitivity (GO:0002883)3.30346554
80regulation of tolerance induction (GO:0002643)3.26853053
81negative regulation of B cell proliferation (GO:0030889)3.26803824
82regulation of interleukin-2 production (GO:0032663)3.26539572
83regulation of isotype switching (GO:0045191)3.26301497
84positive regulation of granulocyte differentiation (GO:0030854)3.25174396
85positive regulation of interferon-alpha production (GO:0032727)3.24541627
86natural killer cell activation (GO:0030101)3.23401181
87regulation of B cell proliferation (GO:0030888)3.19718412
88mast cell activation (GO:0045576)3.19485676
89immune response-activating cell surface receptor signaling pathway (GO:0002429)3.17930976
90B cell proliferation (GO:0042100)3.17576812
91positive regulation of DNA recombination (GO:0045911)3.17230919
92positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.16893889
93regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.16688915
94regulation of natural killer cell mediated immunity (GO:0002715)3.16688915
95regulation of memory T cell differentiation (GO:0043380)3.16475427
96positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.15968597
97negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.13408794
98positive regulation of cell killing (GO:0031343)3.12926106
99lymphocyte homeostasis (GO:0002260)3.12479563
100negative regulation of leukocyte mediated immunity (GO:0002704)3.11145570
101lymphocyte migration (GO:0072676)3.09423791
102defense response to protozoan (GO:0042832)3.08406298
103regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.08106930
104positive regulation of immunoglobulin mediated immune response (GO:0002891)3.08095140
105positive regulation of B cell mediated immunity (GO:0002714)3.08095140
106regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07987662
107T cell differentiation (GO:0030217)3.07707386
108regulation of cell killing (GO:0031341)3.07338186
109regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.07235748
110regulation of interferon-alpha production (GO:0032647)3.04782669
111positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.02825377
112positive regulation of natural killer cell mediated immunity (GO:0002717)3.02825377
113CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.01498669
114positive regulation of T cell differentiation (GO:0045582)3.00435049
115positive regulation of tolerance induction (GO:0002645)3.00048398
116cellular defense response (GO:0006968)2.99587846
117negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.99037843
118macrophage activation involved in immune response (GO:0002281)2.98839461
119negative regulation of interleukin-12 production (GO:0032695)2.98440952
120positive regulation of interleukin-4 production (GO:0032753)2.98109555
121positive regulation of humoral immune response (GO:0002922)2.97038818
122positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.96602744
123interferon-gamma-mediated signaling pathway (GO:0060333)2.96474887
124T cell homeostasis (GO:0043029)2.96076620
125T cell activation involved in immune response (GO:0002286)2.96046233
126positive regulation of immunoglobulin production (GO:0002639)2.95870816
127regulation of alpha-beta T cell activation (GO:0046634)2.95548769
128regulation of response to interferon-gamma (GO:0060330)2.94720407
129positive regulation of B cell proliferation (GO:0030890)2.94284856
130positive regulation of T cell cytokine production (GO:0002726)2.94236810
131regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94172046
132regulation of B cell activation (GO:0050864)2.92878114
133regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.92645018
134positive regulation of T cell activation (GO:0050870)2.91853727
135hepatocyte apoptotic process (GO:0097284)2.91722852
136regulation of immunoglobulin mediated immune response (GO:0002889)2.90865574
137regulation of leukocyte mediated cytotoxicity (GO:0001910)2.90393517
138regulation of B cell mediated immunity (GO:0002712)2.90296604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.54215310
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.30870514
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.91594343
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.10161440
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.99229408
6* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.65192268
7MYC_22102868_ChIP-Seq_BL_Human3.61534284
8RUNX_20019798_ChIP-Seq_JUKART_Human3.53785467
9MYB_26560356_Chip-Seq_TH2_Human3.36235870
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.33512658
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.25081647
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.21465340
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.11943277
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.99251813
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92693628
16* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.89465517
17MAF_26560356_Chip-Seq_TH1_Human2.85692859
18MYB_26560356_Chip-Seq_TH1_Human2.71199976
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.66890998
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53431464
21UTX_26944678_Chip-Seq_JUKART_Human2.37062551
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32058784
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.27340986
24TCF7_22412390_ChIP-Seq_EML_Mouse2.25294585
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.25058873
26VDR_21846776_ChIP-Seq_THP-1_Human2.20061567
27SCL_19346495_ChIP-Seq_HPC-7_Human2.15007151
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13681079
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13582086
30GATA3_27048872_Chip-Seq_THYMUS_Human2.09251627
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.05719801
32E2F7_22180533_ChIP-Seq_HELA_Human2.01586450
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00742485
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00138299
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.94481113
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.82018623
37SPI1_23547873_ChIP-Seq_NB4_Human1.81539974
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77135478
39MAF_26560356_Chip-Seq_TH2_Human1.77042805
40VDR_24763502_ChIP-Seq_THP-1_Human1.75805090
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69145157
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.68910546
43KDM2B_26808549_Chip-Seq_DND41_Human1.68469858
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65221257
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56220229
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50702966
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50476381
48PU_27001747_Chip-Seq_BMDM_Mouse1.49206115
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47699024
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42644396
51GATA3_26560356_Chip-Seq_TH2_Human1.33381188
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29742833
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25918367
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24211279
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24140798
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22472325
57SPI1_23127762_ChIP-Seq_K562_Human1.22465931
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15248893
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12819892
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.08982797
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08420720
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05758028
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.05132476
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05002481
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04868190
66FOXP3_21729870_ChIP-Seq_TREG_Human1.00741367
67GATA1_22025678_ChIP-Seq_K562_Human1.00283127
68VDR_24787735_ChIP-Seq_THP-1_Human0.99438218
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98276788
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98261448
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98073096
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97596372
73PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95663122
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94174927
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93466684
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93010905
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.90684754
78* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89824893
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88479833
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87593042
81GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85810434
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85680835
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85379041
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.85212414
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84484142
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82646652
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82629250
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81970483
89NCOR1_26117541_ChIP-Seq_K562_Human0.81916230
90ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81221909
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78983272
92SMRT_27268052_Chip-Seq_Bcells_Human0.78835165
93CIITA_25753668_ChIP-Seq_RAJI_Human0.78444968
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77996593
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76445701
96GATA2_19941826_ChIP-Seq_K562_Human0.76403369
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75653563
98GATA1_19941826_ChIP-Seq_K562_Human0.72961080
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72864416
100TP63_17297297_ChIP-ChIP_HaCaT_Human0.72256997
101SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.71670871
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70075716
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69866144
104GATA3_26560356_Chip-Seq_TH1_Human0.68145219
105RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68077236
106CLOCK_20551151_ChIP-Seq_293T_Human0.67938869
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67845115
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67665211
109FOXM1_23109430_ChIP-Seq_U2OS_Human0.67291473
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67123399
111BCL6_27268052_Chip-Seq_Bcells_Human0.66607236
112* VDR_23849224_ChIP-Seq_CD4+_Human0.64521601
113ETS1_22383799_ChIP-Seq_G1ME_Mouse0.63956523
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.63239316
115TFEB_21752829_ChIP-Seq_HELA_Human0.63012190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.28776673
2MP0003763_abnormal_thymus_physiology4.21459054
3MP0005671_abnormal_response_to4.08621267
4MP0000685_abnormal_immune_system3.88995544
5MP0005387_immune_system_phenotype3.62704484
6MP0001790_abnormal_immune_system3.62704484
7MP0001800_abnormal_humoral_immune3.51372648
8MP0005000_abnormal_immune_tolerance3.13242000
9MP0002723_abnormal_immune_serum2.87540000
10MP0002166_altered_tumor_susceptibility2.83941623
11MP0003303_peritoneal_inflammation2.83371151
12MP0002452_abnormal_antigen_presenting2.82836090
13MP0001873_stomach_inflammation2.74086725
14MP0002420_abnormal_adaptive_immunity2.73700690
15MP0001819_abnormal_immune_cell2.72223909
16MP0003300_gastrointestinal_ulcer2.64818738
17MP0002398_abnormal_bone_marrow2.60808973
18MP0009785_altered_susceptibility_to2.57842552
19MP0002148_abnormal_hypersensitivity_rea2.46981257
20MP0002006_tumorigenesis2.45809734
21MP0005025_abnormal_response_to2.40790141
22MP0004510_myositis2.40665241
23MP0000716_abnormal_immune_system2.35882429
24MP0002405_respiratory_system_inflammati2.31631158
25MP0003436_decreased_susceptibility_to2.30927710
26MP0004947_skin_inflammation2.28241065
27MP0001853_heart_inflammation2.23723970
28MP0000703_abnormal_thymus_morphology2.20836021
29MP0002009_preneoplasia2.10799170
30MP0002722_abnormal_immune_system2.08772823
31MP0010155_abnormal_intestine_physiology2.07345173
32MP0000689_abnormal_spleen_morphology2.03997610
33MP0009333_abnormal_splenocyte_physiolog2.02209271
34MP0002138_abnormal_hepatobiliary_system1.96203570
35MP0005310_abnormal_salivary_gland1.94526162
36MP0002419_abnormal_innate_immunity1.93879143
37MP0002429_abnormal_blood_cell1.85881644
38MP0006082_CNS_inflammation1.85528504
39MP0003866_abnormal_defecation1.82916559
40MP0001845_abnormal_inflammatory_respons1.74471290
41MP0003724_increased_susceptibility_to1.73789221
42MP0002933_joint_inflammation1.65858343
43MP0001348_abnormal_lacrimal_gland1.61485965
44MP0005464_abnormal_platelet_physiology1.51432050
45MP0002163_abnormal_gland_morphology1.45375301
46MP0002396_abnormal_hematopoietic_system1.42272569
47MP0004808_abnormal_hematopoietic_stem1.31943185
48MP0000465_gastrointestinal_hemorrhage1.28002807
49MP0003448_altered_tumor_morphology1.27253028
50MP0008057_abnormal_DNA_replication1.25256991
51MP0004381_abnormal_hair_follicle1.24212641
52MP0000858_altered_metastatic_potential1.22677654
53MP0001851_eye_inflammation1.19031505
54MP0000490_abnormal_crypts_of1.14867936
55MP0002877_abnormal_melanocyte_morpholog1.10476881
56MP0005451_abnormal_body_composition1.09487176
57MP0001545_abnormal_hematopoietic_system1.06338445
58MP0005397_hematopoietic_system_phenotyp1.06338445
59MP0008469_abnormal_protein_level1.04317441
60MP0010352_gastrointestinal_tract_polyps1.03195792
61MP0001533_abnormal_skeleton_physiology1.00388781
62MP0005076_abnormal_cell_differentiation0.94945424
63MP0002998_abnormal_bone_remodeling0.94592417
64MP0008260_abnormal_autophagy0.91491077
65MP0002019_abnormal_tumor_incidence0.88661124
66MP0005645_abnormal_hypothalamus_physiol0.87817866
67MP0002277_abnormal_respiratory_mucosa0.87793283
68MP0003091_abnormal_cell_migration0.87643165
69MP0005075_abnormal_melanosome_morpholog0.83619187
70MP0008961_abnormal_basal_metabolism0.80186518
71MP0002132_abnormal_respiratory_system0.79168780
72MP0003787_abnormal_imprinting0.78300653
73MP0003453_abnormal_keratinocyte_physiol0.78065774
74MP0009278_abnormal_bone_marrow0.77464515
75MP0000249_abnormal_blood_vessel0.75505707
76MP0002254_reproductive_system_inflammat0.74884238
77MP0009764_decreased_sensitivity_to0.73261530
78MP0001881_abnormal_mammary_gland0.73056324
79MP0003172_abnormal_lysosome_physiology0.70343001
80MP0002136_abnormal_kidney_physiology0.66910640
81MP0005174_abnormal_tail_pigmentation0.65970709
82MP0000015_abnormal_ear_pigmentation0.65704091
83MP0001663_abnormal_digestive_system0.65146073
84MP0003828_pulmonary_edema0.64394752
85MP0001216_abnormal_epidermal_layer0.63858631
86MP0009763_increased_sensitivity_to0.61657667
87MP0001243_abnormal_dermal_layer0.60472786
88MP0000609_abnormal_liver_physiology0.59083831
89MP0002693_abnormal_pancreas_physiology0.58532968
90MP0000367_abnormal_coat/_hair0.57858006
91MP0002928_abnormal_bile_duct0.57819913
92MP0005379_endocrine/exocrine_gland_phen0.56031462
93MP0008007_abnormal_cellular_replicative0.54932523
94MP0003795_abnormal_bone_structure0.54226134
95MP0003252_abnormal_bile_duct0.53824954
96MP0004883_abnormal_blood_vessel0.52793863
97MP0000627_abnormal_mammary_gland0.51886947
98MP0005023_abnormal_wound_healing0.51854523
99MP0008874_decreased_physiological_sensi0.51683486
100MP0003656_abnormal_erythrocyte_physiolo0.49377267
101MP0001919_abnormal_reproductive_system0.47887839
102MP0001191_abnormal_skin_condition0.47725752
103MP0000477_abnormal_intestine_morphology0.47080574
104MP0003045_fibrosis0.46452926
105MP0000569_abnormal_digit_pigmentation0.46369153
106MP0003191_abnormal_cellular_cholesterol0.46205936
107MP0003075_altered_response_to0.44731423
108MP0008873_increased_physiological_sensi0.43728840
109MP0009765_abnormal_xenobiotic_induced0.43099979
110MP0000343_altered_response_to0.43063966
111MP0009115_abnormal_fat_cell0.41827483
112MP0005390_skeleton_phenotype0.41728281
113MP0005621_abnormal_cell_physiology0.41569890
114MP0003221_abnormal_cardiomyocyte_apopto0.41376715
115MP0000313_abnormal_cell_death0.41203232
116MP0005166_decreased_susceptibility_to0.41043700
117MP0000371_diluted_coat_color0.40223197
118MP0003183_abnormal_peptide_metabolism0.39777526

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)6.20075822
2Optic neuritis (HP:0100653)6.20075822
3Myositis (HP:0100614)5.75022952
4Orchitis (HP:0100796)5.45707296
5Abnormality of T cell number (HP:0011839)5.33847930
6Stomatitis (HP:0010280)5.18764513
7T lymphocytopenia (HP:0005403)5.15243166
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.79374471
9Recurrent viral infections (HP:0004429)4.72421550
10Panhypogammaglobulinemia (HP:0003139)4.55204938
11Autoimmune hemolytic anemia (HP:0001890)4.43673463
12Pulmonary infiltrates (HP:0002113)4.38958148
13Elevated erythrocyte sedimentation rate (HP:0003565)4.35215452
14Keratoconjunctivitis sicca (HP:0001097)4.29192402
15IgM deficiency (HP:0002850)4.28955415
16Recurrent fungal infections (HP:0002841)4.25962942
17Vasculitis (HP:0002633)4.25574385
18Recurrent bronchitis (HP:0002837)4.24028270
19Abnormality of T cells (HP:0002843)4.20740455
20Agammaglobulinemia (HP:0004432)4.11631940
21Meningitis (HP:0001287)4.01168806
22Keratoconjunctivitis (HP:0001096)3.89900351
23Arterial thrombosis (HP:0004420)3.86113632
24Severe combined immunodeficiency (HP:0004430)3.75253757
25Abnormality of B cell number (HP:0010975)3.74648366
26B lymphocytopenia (HP:0010976)3.74648366
27Encephalitis (HP:0002383)3.70605360
28IgG deficiency (HP:0004315)3.60559594
29Eczematoid dermatitis (HP:0000976)3.60104095
30Thyroiditis (HP:0100646)3.59188855
31Recurrent cutaneous fungal infections (HP:0011370)3.49590092
32Chronic mucocutaneous candidiasis (HP:0002728)3.49590092
33Hemoptysis (HP:0002105)3.46311662
34Chronic otitis media (HP:0000389)3.43668844
35Combined immunodeficiency (HP:0005387)3.42451179
36Gastrointestinal infarctions (HP:0005244)3.38393558
37Inflammation of the large intestine (HP:0002037)3.35493833
38Abnormality of T cell physiology (HP:0011840)3.34361098
39Abnormality of macrophages (HP:0004311)3.33988719
40Mediastinal lymphadenopathy (HP:0100721)3.33748518
41Colitis (HP:0002583)3.33107613
42Eosinophilia (HP:0001880)3.30944864
43Gastrointestinal stroma tumor (HP:0100723)3.28585074
44Abnormality of eosinophils (HP:0001879)3.25840448
45Abnormality of cells of the lymphoid lineage (HP:0012140)3.22972515
46Lymphopenia (HP:0001888)3.20451339
47Nasal polyposis (HP:0100582)3.18026359
48Gastrointestinal inflammation (HP:0004386)3.17279061
49Increased density of long bones (HP:0006392)2.96574786
50Abnormality of the fingertips (HP:0001211)2.95527387
51Gangrene (HP:0100758)2.95378272
52Pulmonary embolism (HP:0002204)2.94598355
53Autoimmune thrombocytopenia (HP:0001973)2.91980480
54Leukocytosis (HP:0001974)2.85722331
55Abnormality of the prostate (HP:0008775)2.85063771
56Recurrent abscess formation (HP:0002722)2.85032881
57IgA deficiency (HP:0002720)2.84723197
58Urticaria (HP:0001025)2.84395146
59Increased IgM level (HP:0003496)2.82480083
60Recurrent bacterial skin infections (HP:0005406)2.79748624
61Granulocytopenia (HP:0001913)2.79697201
62Recurrent sinusitis (HP:0011108)2.78389451
63Chest pain (HP:0100749)2.78253242
64Chronic obstructive pulmonary disease (HP:0006510)2.77673758
65Obstructive lung disease (HP:0006536)2.77673758
66Increased IgE level (HP:0003212)2.72890004
67Verrucae (HP:0200043)2.72054288
68Papilloma (HP:0012740)2.72054288
69Persistence of primary teeth (HP:0006335)2.65361128
70Recurrent skin infections (HP:0001581)2.63958422
71Abnormality of the nasal mucosa (HP:0000433)2.63001306
72Thrombocytosis (HP:0001894)2.62377817
73Joint swelling (HP:0001386)2.61353714
74Recurrent gram-negative bacterial infections (HP:0005420)2.57199457
75Prolonged bleeding time (HP:0003010)2.55615446
76Cellulitis (HP:0100658)2.55293282
77Sepsis (HP:0100806)2.49110338
78Chronic diarrhea (HP:0002028)2.48418864
79Basal cell carcinoma (HP:0002671)2.45043512
80Emphysema (HP:0002097)2.40098997
81Skin rash (HP:0000988)2.39775814
82Lymphoma (HP:0002665)2.39097913
83Recurrent pneumonia (HP:0006532)2.38062429
84Spontaneous hematomas (HP:0007420)2.36687528
85Viral hepatitis (HP:0006562)2.36034208
86Pustule (HP:0200039)2.34004293
87Anorexia (HP:0002039)2.30525450
88Bronchitis (HP:0012387)2.29752608
89Fatigue (HP:0012378)2.29328655
90Glomerulopathy (HP:0100820)2.28076551
91Recurrent lower respiratory tract infections (HP:0002783)2.26471715
92Acute hepatic failure (HP:0006554)2.24675214
93Hypergammaglobulinemia (HP:0010702)2.24210426
94Arthralgia (HP:0002829)2.15875773
95Chronic sinusitis (HP:0011109)2.15401812
96Abnormality of the pleura (HP:0002103)2.14276199
97Petechiae (HP:0000967)2.13994592
98Thrombophlebitis (HP:0004418)2.13851101
99Amaurosis fugax (HP:0100576)2.12247248
100Osteomyelitis (HP:0002754)2.11897435
101Gingivitis (HP:0000230)2.10278064
102Restrictive lung disease (HP:0002091)2.09913886
103Keratitis (HP:0000491)2.09185486
104Polyneuropathy (HP:0001271)2.06120287
105Premature loss of primary teeth (HP:0006323)2.05732636
106Gingival bleeding (HP:0000225)2.05614269
107Recurrent otitis media (HP:0000403)2.05205195
108Abnormality of the pericardium (HP:0001697)2.04804930
109Papilledema (HP:0001085)2.03652268
110Interstitial pulmonary disease (HP:0006530)2.03562866
111Skin ulcer (HP:0200042)2.02783300
112Hypoplasia of the thymus (HP:0000778)1.99804745
113Muscle fiber atrophy (HP:0100295)1.93820500
114Ureteral stenosis (HP:0000071)1.90876454
115Periodontitis (HP:0000704)1.87386240
116Epistaxis (HP:0000421)1.84446949
117Hypochromic anemia (HP:0001931)1.83676615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.03424234
2MAP4K15.24296979
3MAP3K143.50933892
4PRPF4B2.89233984
5JAK32.71747727
6ITK2.70073611
7GRK62.61278131
8TYK22.46970211
9JAK12.37269609
10TBK12.22808497
11IKBKE2.18964281
12IKBKB2.17448446
13TAOK32.13698983
14STK102.10201820
15ZAP702.09466466
16IRAK31.98442850
17MAP3K131.90908838
18MST41.89656778
19TEC1.87802031
20FGFR41.83424385
21BTK1.81668613
22SYK1.78253330
23PASK1.76659372
24CHUK1.68346862
25TESK21.63448419
26EEF2K1.59513649
27FGFR31.58041663
28LCK1.51273416
29MAP3K101.49841298
30PIM11.49388668
31BRD41.49261592
32HCK1.45134209
33NLK1.33382255
34LRRK21.31506225
35CSK1.31390816
36KIT1.29622778
37RIPK41.25302526
38BLK1.24381380
39IRAK41.24365634
40EPHB11.17792384
41CSF1R1.13819160
42EPHA31.11101592
43JAK21.05489655
44PRKCQ1.02470524
45CAMKK11.00936495
46SMG10.98653589
47CAMKK20.97697651
48STK240.96198291
49SIK20.94640786
50CDK40.94465601
51TSSK60.89711161
52CDK120.85981243
53SIK30.83815922
54RPS6KA40.81723597
55LYN0.81602247
56MARK30.78220457
57CDK60.74209198
58CLK10.74021516
59MAP2K30.73732845
60FGR0.71956498
61FES0.71450743
62CDK90.71148761
63TGFBR20.68359364
64TNK20.67150752
65MAP3K70.66756311
66HIPK20.66648620
67MAP3K110.64447869
68VRK10.62869984
69MAPK120.62339945
70DYRK1B0.60603224
71NEK90.58004370
72MAP3K10.57122445
73PRKCH0.56124716
74CDK190.53667054
75PDK10.53567717
76PIK3CG0.53010611
77TLK10.52817057
78MELK0.48003149
79PDGFRB0.47809548
80EIF2AK30.47191487
81STK40.46445991
82RIPK10.45790708
83ALK0.45631482
84YES10.45156754
85IRAK20.42869878
86TAOK20.42745492
87RPS6KA50.42684218
88MAPKAPK20.42545571
89MAP3K50.41374004
90TRPM70.41019356
91PTK60.39647810
92TRIB30.39292905
93IRAK10.38936782
94ABL10.37076550
95MAPK70.36574118
96MAP3K80.35604437
97FYN0.35429274
98KDR0.35233917
99FLT30.34445160
100INSR0.33183124
101PIM20.30702650
102BMPR20.29899084
103SGK30.29890252
104RPS6KB10.29430454
105GSK3A0.29265488
106TYRO30.29182060
107KSR20.29134305
108NUAK10.28982589
109RPS6KA10.28453725
110MAP2K20.28115071
111IGF1R0.28065189
112DYRK30.26531428
113MAPK40.25247495
114MAPK30.24534626
115PDPK10.24481000
116RPS6KB20.24088645
117PRKCD0.23848727
118MAP2K60.23816154
119MATK0.23792856
120DMPK0.22477669
121MAPK110.22290941
122TAOK10.22192736
123MAP3K30.21423878
124ERN10.20857925
125MARK20.19741091
126PKN20.19674758
127STK110.18637525
128CDC42BPA0.18404193
129RAF10.18017281

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.84273102
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.32213779
3T cell receptor signaling pathway_Homo sapiens_hsa046603.28617019
4Allograft rejection_Homo sapiens_hsa053303.25970209
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.22879778
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.98955059
7Graft-versus-host disease_Homo sapiens_hsa053322.86946641
8Autoimmune thyroid disease_Homo sapiens_hsa053202.68707395
9Measles_Homo sapiens_hsa051622.66015265
10B cell receptor signaling pathway_Homo sapiens_hsa046622.56786781
11Antigen processing and presentation_Homo sapiens_hsa046122.45651382
12Osteoclast differentiation_Homo sapiens_hsa043802.42902878
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.36713644
14Leishmaniasis_Homo sapiens_hsa051402.28731640
15Hematopoietic cell lineage_Homo sapiens_hsa046402.16450887
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.85430895
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69347473
18Toxoplasmosis_Homo sapiens_hsa051451.68366110
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63523156
20Asthma_Homo sapiens_hsa053101.57414985
21TNF signaling pathway_Homo sapiens_hsa046681.55851285
22Chemokine signaling pathway_Homo sapiens_hsa040621.52636608
23Herpes simplex infection_Homo sapiens_hsa051681.51636089
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38957146
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.38904353
26Influenza A_Homo sapiens_hsa051641.38076174
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32741958
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30443020
29Apoptosis_Homo sapiens_hsa042101.28634251
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27328380
31Hepatitis B_Homo sapiens_hsa051611.27220817
32Acute myeloid leukemia_Homo sapiens_hsa052211.26290333
33Viral myocarditis_Homo sapiens_hsa054161.24037630
34Type I diabetes mellitus_Homo sapiens_hsa049401.23795290
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23429155
36Systemic lupus erythematosus_Homo sapiens_hsa053221.22200369
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.16486765
38Epstein-Barr virus infection_Homo sapiens_hsa051691.08861402
39HTLV-I infection_Homo sapiens_hsa051661.06598002
40Shigellosis_Homo sapiens_hsa051311.05753870
41Chronic myeloid leukemia_Homo sapiens_hsa052201.05719752
42Legionellosis_Homo sapiens_hsa051341.01652550
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00529887
44Tuberculosis_Homo sapiens_hsa051520.99575126
45Prolactin signaling pathway_Homo sapiens_hsa049170.97332598
46Malaria_Homo sapiens_hsa051440.93377481
47Pancreatic cancer_Homo sapiens_hsa052120.91349185
48Non-small cell lung cancer_Homo sapiens_hsa052230.90590982
49Platelet activation_Homo sapiens_hsa046110.90398442
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90051959
51Hepatitis C_Homo sapiens_hsa051600.84649318
52Viral carcinogenesis_Homo sapiens_hsa052030.81007349
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79734982
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.78272585
55Small cell lung cancer_Homo sapiens_hsa052220.77920232
56African trypanosomiasis_Homo sapiens_hsa051430.77232192
57Pertussis_Homo sapiens_hsa051330.74711133
58Colorectal cancer_Homo sapiens_hsa052100.67655542
59FoxO signaling pathway_Homo sapiens_hsa040680.67453653
60MAPK signaling pathway_Homo sapiens_hsa040100.64781638
61Rheumatoid arthritis_Homo sapiens_hsa053230.64074860
62Staphylococcus aureus infection_Homo sapiens_hsa051500.61566980
63Salmonella infection_Homo sapiens_hsa051320.61529479
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60570584
65VEGF signaling pathway_Homo sapiens_hsa043700.57299553
66Phagosome_Homo sapiens_hsa041450.55147187
67Non-homologous end-joining_Homo sapiens_hsa034500.52866359
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52589940
69p53 signaling pathway_Homo sapiens_hsa041150.52520076
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.52263130
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48467687
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47705337
73MicroRNAs in cancer_Homo sapiens_hsa052060.43959499
74Circadian rhythm_Homo sapiens_hsa047100.43895863
75Prostate cancer_Homo sapiens_hsa052150.43415584
76Insulin resistance_Homo sapiens_hsa049310.42469831
77Endocytosis_Homo sapiens_hsa041440.41627070
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37097898
79Ribosome_Homo sapiens_hsa030100.37084870
80Renal cell carcinoma_Homo sapiens_hsa052110.36388265
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34035502
82Inositol phosphate metabolism_Homo sapiens_hsa005620.32714863
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31953881
84Notch signaling pathway_Homo sapiens_hsa043300.31752039
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31036341
86Pathways in cancer_Homo sapiens_hsa052000.31003273
87HIF-1 signaling pathway_Homo sapiens_hsa040660.29994577
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27805031
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.27570905
90Alcoholism_Homo sapiens_hsa050340.27398777
91Choline metabolism in cancer_Homo sapiens_hsa052310.26314518
92Endometrial cancer_Homo sapiens_hsa052130.25846136
93mTOR signaling pathway_Homo sapiens_hsa041500.25739693
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25609427
95Dorso-ventral axis formation_Homo sapiens_hsa043200.25497283
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24213435
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24179431
98Spliceosome_Homo sapiens_hsa030400.23870838
99Proteoglycans in cancer_Homo sapiens_hsa052050.23397515
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23024848
101ErbB signaling pathway_Homo sapiens_hsa040120.22751440
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20868061
103RNA degradation_Homo sapiens_hsa030180.20461570
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20404754
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18830248
106Type II diabetes mellitus_Homo sapiens_hsa049300.16949180
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16014652
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.15977763
109Adherens junction_Homo sapiens_hsa045200.15453674
110GnRH signaling pathway_Homo sapiens_hsa049120.14670539
111Amoebiasis_Homo sapiens_hsa051460.13861277
112Long-term potentiation_Homo sapiens_hsa047200.11725770
113Glioma_Homo sapiens_hsa052140.11260632
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09232637
115Ras signaling pathway_Homo sapiens_hsa040140.08749240
116Regulation of autophagy_Homo sapiens_hsa041400.07815784
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.07172959
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05330810

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