P2RY12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)9.50846211
2macrophage activation involved in immune response (GO:0002281)8.29530328
3positive regulation of chemokine secretion (GO:0090197)7.54526381
4chondroitin sulfate catabolic process (GO:0030207)7.06832469
5oligosaccharide catabolic process (GO:0009313)6.82361055
6glycosphingolipid catabolic process (GO:0046479)6.71213946
7phosphatidylglycerol biosynthetic process (GO:0006655)6.16241969
8macrophage activation (GO:0042116)6.10889120
9* G-protein coupled purinergic receptor signaling pathway (GO:0035588)6.06178962
10neutrophil activation involved in immune response (GO:0002283)6.04414413
11glycolipid catabolic process (GO:0019377)6.03822215
12thrombin receptor signaling pathway (GO:0070493)5.83750469
13regulation of chemokine secretion (GO:0090196)5.70444861
14negative regulation of multicellular organism growth (GO:0040015)5.65781272
15ceramide catabolic process (GO:0046514)5.56669714
16macrophage chemotaxis (GO:0048246)5.38398636
17* purinergic nucleotide receptor signaling pathway (GO:0035590)5.38351351
18keratan sulfate catabolic process (GO:0042340)5.30940596
19phenylpropanoid metabolic process (GO:0009698)5.22978883
20protein neddylation (GO:0045116)5.19321644
21negative regulation of granulocyte differentiation (GO:0030853)5.11276208
22regulation of platelet activation (GO:0010543)5.10420635
23positive regulation of myeloid leukocyte mediated immunity (GO:0002888)5.04832667
24positive regulation of mast cell activation (GO:0033005)4.99920805
25regulation of B cell receptor signaling pathway (GO:0050855)4.99609774
26regulation of interferon-beta biosynthetic process (GO:0045357)4.98855866
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.95207319
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.94205794
29adaptation of signaling pathway (GO:0023058)4.80946046
30negative regulation of systemic arterial blood pressure (GO:0003085)4.72012977
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.64037610
32positive regulation by organism of defense response of other organism involved in symbiotic interact4.64037610
33modulation by symbiont of host immune response (GO:0052553)4.64037610
34positive regulation by symbiont of host defense response (GO:0052509)4.64037610
35modulation by symbiont of host defense response (GO:0052031)4.64037610
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.64037610
37hyaluronan catabolic process (GO:0030214)4.49517879
38mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.43730755
39regulation of hypersensitivity (GO:0002883)4.39071054
40cyclooxygenase pathway (GO:0019371)4.37110777
41negative regulation of smooth muscle contraction (GO:0045986)4.28879247
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.28203510
43* purinergic receptor signaling pathway (GO:0035587)4.26428859
44blood coagulation, intrinsic pathway (GO:0007597)4.24754484
45negative regulation of platelet activation (GO:0010544)4.22263629
46leukocyte migration involved in inflammatory response (GO:0002523)4.18387779
47myeloid cell activation involved in immune response (GO:0002275)4.06018701
48lytic vacuole organization (GO:0080171)4.05812420
49lysosome organization (GO:0007040)4.05812420
50ruffle organization (GO:0031529)4.05640472
51Rac protein signal transduction (GO:0016601)4.02920203
52negative regulation of homotypic cell-cell adhesion (GO:0034111)4.02737888
53negative regulation of cAMP-mediated signaling (GO:0043951)3.99922608
54regulation of myeloid leukocyte mediated immunity (GO:0002886)3.85002731
55ganglioside metabolic process (GO:0001573)3.83584307
56positive regulation of mast cell degranulation (GO:0043306)3.77773304
57positive regulation of mast cell activation involved in immune response (GO:0033008)3.77773304
58neutrophil activation (GO:0042119)3.76346340
59angiogenesis involved in wound healing (GO:0060055)3.72264109
60glial cell migration (GO:0008347)3.71539059
61positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.71326436
62tolerance induction (GO:0002507)3.64098867
63positive regulation of endothelial cell differentiation (GO:0045603)3.59058693
64regulation of integrin-mediated signaling pathway (GO:2001044)3.56350823
65regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.55758654
66response to host (GO:0075136)3.55559195
67response to host defenses (GO:0052200)3.55559195
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.55559195
69negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.54199962
70negative regulation of T-helper cell differentiation (GO:0045623)3.54199962
71sodium-independent organic anion transport (GO:0043252)3.53994129
72low-density lipoprotein particle remodeling (GO:0034374)3.53563343
73negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.51860449
74* platelet aggregation (GO:0070527)3.49024939
75megakaryocyte development (GO:0035855)3.48890908
76regulation of macrophage chemotaxis (GO:0010758)3.45765145
77regulation of lipoprotein metabolic process (GO:0050746)3.45152952
78negative regulation of thymocyte apoptotic process (GO:0070244)3.45054569
79oligosaccharide metabolic process (GO:0009311)3.44574636
80outer ear morphogenesis (GO:0042473)3.41763941
81lipoxygenase pathway (GO:0019372)3.41332534
82granulocyte activation (GO:0036230)3.35439821
83positive regulation of B cell differentiation (GO:0045579)3.34850593
84positive regulation of cellular amide metabolic process (GO:0034250)3.33777335
85regulation of MHC class II biosynthetic process (GO:0045346)3.33521392
86nucleoside diphosphate catabolic process (GO:0009134)3.33339583
87regulation of interferon-alpha production (GO:0032647)3.31875465
88adrenergic receptor signaling pathway (GO:0071875)3.31609919
89negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.31171243
90positive regulation of interferon-alpha production (GO:0032727)3.31168563
91positive regulation of macrophage differentiation (GO:0045651)3.30321586
92regulation of mast cell activation (GO:0033003)3.30193678
93platelet formation (GO:0030220)3.28216681
94regulation of integrin activation (GO:0033623)3.25588556
95monocyte differentiation (GO:0030224)3.23493448
96negative regulation of muscle contraction (GO:0045932)3.23047892
97negative regulation of heart rate (GO:0010459)3.22910926
98positive regulation of B cell mediated immunity (GO:0002714)3.21871980
99positive regulation of immunoglobulin mediated immune response (GO:0002891)3.21871980
100* adenosine receptor signaling pathway (GO:0001973)3.21239039
101platelet degranulation (GO:0002576)3.21205549
102positive regulation of microtubule polymerization (GO:0031116)3.18354882
103positive regulation of receptor recycling (GO:0001921)3.17227334
104response to laminar fluid shear stress (GO:0034616)3.11985877
105phagocytosis, engulfment (GO:0006911)3.11008134
106histamine secretion (GO:0001821)3.10291210
107I-kappaB phosphorylation (GO:0007252)3.08234070
108negative regulation of tissue remodeling (GO:0034104)3.08228045
109sphingolipid catabolic process (GO:0030149)3.08048710
110* platelet activation (GO:0030168)3.07399919
111negative regulation of heart contraction (GO:0045822)3.07209637
112regulation of T cell tolerance induction (GO:0002664)3.06491940
113negative regulation of interleukin-6 production (GO:0032715)3.05848527
114negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.03609515
115regulation of mast cell degranulation (GO:0043304)3.03104724
116positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.01026224
117negative regulation of interleukin-17 production (GO:0032700)3.00255544
118positive regulation of antigen processing and presentation (GO:0002579)2.98524346
119membrane invagination (GO:0010324)2.98093981
120phagocytosis, recognition (GO:0006910)2.97505616
121regulation of homotypic cell-cell adhesion (GO:0034110)2.95412439
122positive regulation of smooth muscle cell migration (GO:0014911)2.94174830
123negative regulation of protein localization to cell surface (GO:2000009)2.94082837
124cellular response to fluid shear stress (GO:0071498)2.93760966
125regulation of mast cell activation involved in immune response (GO:0033006)2.93682429
126negative regulation of B cell proliferation (GO:0030889)2.93625198
127regulation of monocyte chemotaxis (GO:0090025)2.92883263
128regulation of chemokine-mediated signaling pathway (GO:0070099)2.92404112
129myeloid leukocyte activation (GO:0002274)2.91292377
130regulation of Golgi to plasma membrane protein transport (GO:0042996)2.89698187
131positive regulation of systemic arterial blood pressure (GO:0003084)2.88873320
132regulation of macrophage derived foam cell differentiation (GO:0010743)2.86663017
133negative regulation of smooth muscle cell migration (GO:0014912)2.86522509
134regulation of T-helper 1 cell differentiation (GO:0045625)2.86131769
135response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85504820
136response to host immune response (GO:0052572)2.85504820
137positive regulation of hemostasis (GO:1900048)2.80265776
138positive regulation of blood coagulation (GO:0030194)2.80265776
139regulation of female receptivity (GO:0045924)2.79399357
140positive regulation of muscle hypertrophy (GO:0014742)2.78743046
141positive regulation of cardiac muscle hypertrophy (GO:0010613)2.78743046
142activated T cell proliferation (GO:0050798)2.78471830
143mannose metabolic process (GO:0006013)2.78408141
144negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78153857
145negative regulation of translation, ncRNA-mediated (GO:0040033)2.78153857
146regulation of translation, ncRNA-mediated (GO:0045974)2.78153857
147long-chain fatty acid biosynthetic process (GO:0042759)2.77945096
148regulation of alkaline phosphatase activity (GO:0010692)2.77372025
149positive regulation of Rho protein signal transduction (GO:0035025)2.76928587
150response to muramyl dipeptide (GO:0032495)2.76869962
151pathway-restricted SMAD protein phosphorylation (GO:0060389)2.76801691
152negative regulation of skeletal muscle tissue development (GO:0048642)2.75771025
153leukocyte degranulation (GO:0043299)2.75568695
154regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.75390404
155negative regulation of response to food (GO:0032096)2.75208508
156negative regulation of appetite (GO:0032099)2.75208508
157reverse cholesterol transport (GO:0043691)2.74642338
158membrane lipid catabolic process (GO:0046466)2.73374020
159regulation of T-helper 2 cell differentiation (GO:0045628)2.72815146
160regulation of platelet aggregation (GO:0090330)2.71271127
161cellular response to ethanol (GO:0071361)2.70065652
162activation of protein kinase A activity (GO:0034199)2.69900390
163actin filament polymerization (GO:0030041)2.69557234
164negative regulation of neural precursor cell proliferation (GO:2000178)2.69456422
165positive regulation of toll-like receptor signaling pathway (GO:0034123)2.69048366
166multicellular organismal reproductive behavior (GO:0033057)2.68578899
167regulation of B cell differentiation (GO:0045577)2.68365766
168oogenesis (GO:0048477)2.68075089
169regulation of inositol phosphate biosynthetic process (GO:0010919)2.67348925
170negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66687471
171positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66190159
172termination of G-protein coupled receptor signaling pathway (GO:0038032)2.65589559
173polyamine biosynthetic process (GO:0006596)2.65268800
174cell-cell junction maintenance (GO:0045217)2.65173514
175positive regulation of cAMP-mediated signaling (GO:0043950)2.64822251
176regulation of leukocyte degranulation (GO:0043300)2.64746545
177negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.63972090
178prostaglandin metabolic process (GO:0006693)2.63738024
179prostanoid metabolic process (GO:0006692)2.63738024
180negative regulation of bone resorption (GO:0045779)2.62909170
181response to cholesterol (GO:0070723)2.62283591
182phagocytosis (GO:0006909)2.62181464
183termination of signal transduction (GO:0023021)2.61558834
184positive regulation of Rap GTPase activity (GO:0032854)2.61141838
185high-density lipoprotein particle remodeling (GO:0034375)2.61060281
186microglial cell activation (GO:0001774)11.9778127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.13745722
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.78395939
3IRF8_27001747_Chip-Seq_BMDM_Mouse4.00946313
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.77164323
5SCL_19346495_ChIP-Seq_HPC-7_Human3.25092805
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.14659283
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.11401146
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.05134550
9GATA1_22025678_ChIP-Seq_K562_Human3.03517288
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.88439702
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.71437763
12EZH2_22144423_ChIP-Seq_EOC_Human2.71179844
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65638504
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41509411
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.19953060
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.17728231
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16911822
18RUNX_20019798_ChIP-Seq_JUKART_Human2.14645839
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09436043
20SPI1_23127762_ChIP-Seq_K562_Human2.06766836
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00507356
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.98799997
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89175486
24GBX2_23144817_ChIP-Seq_PC3_Human1.85819712
25VDR_24787735_ChIP-Seq_THP-1_Human1.73030594
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.72380572
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66361515
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62924933
29VDR_24763502_ChIP-Seq_THP-1_Human1.59383947
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56754241
31GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.53347517
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.48542819
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47067261
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46596202
35GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46442999
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45494570
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.44890803
38* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42393576
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41620412
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.39553299
41EGR1_19032775_ChIP-ChIP_M12_Human1.38236607
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34051540
43GATA1_19941827_ChIP-Seq_MEL86_Mouse1.33750709
44HTT_18923047_ChIP-ChIP_STHdh_Human1.30338087
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28662691
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28281010
47TCF7_22412390_ChIP-Seq_EML_Mouse1.26976783
48DROSHA_22980978_ChIP-Seq_HELA_Human1.24592744
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.24495323
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23633385
51GATA2_19941826_ChIP-Seq_K562_Human1.22633180
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.22619083
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22592170
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18830696
55* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18586665
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18490695
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18346101
58SPI1_23547873_ChIP-Seq_NB4_Human1.18114296
59TAF15_26573619_Chip-Seq_HEK293_Human1.17954085
60KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.17630803
61* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17440327
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16177844
63GATA1_19941826_ChIP-Seq_K562_Human1.15901631
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14587497
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13998982
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13958717
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13958717
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12351991
69SMRT_27268052_Chip-Seq_Bcells_Human1.12351878
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11832594
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11212040
72PU_27001747_Chip-Seq_BMDM_Mouse1.11054358
73CLOCK_20551151_ChIP-Seq_293T_Human1.10405963
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09472564
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09472564
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09472564
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06685088
78LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02936591
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01620389
80SALL4_22934838_ChIP-ChIP_CD34+_Human1.00495178
81TCF4_22108803_ChIP-Seq_LS180_Human0.98611500
82KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98349570
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97591953
84GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97187591
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95948632
86* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95373984
87* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95273770
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93891470
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93562900
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91851236
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91659352
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.91333770
93MAF_26560356_Chip-Seq_TH1_Human0.90325071
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90103208
95GF1_26923725_Chip-Seq_HPCs_Mouse0.89927876
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89683558
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89571726
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89571726
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.88871392
100LXR_22158963_ChIP-Seq_LIVER_Mouse0.88844066
101SMAD4_21799915_ChIP-Seq_A2780_Human0.88695164
102SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88423616
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88186829
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.87308905
105OCT1_27270436_Chip-Seq_PROSTATE_Human0.86986790
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.86929468
107CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86176491
108BCAT_22108803_ChIP-Seq_LS180_Human0.85343983
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84961648
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84195836
111* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83748120
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83701181
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83525221
114SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.82625691
115MYB_26560356_Chip-Seq_TH2_Human0.82428060
116* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82051920
117SPI1_20517297_ChIP-Seq_HL60_Human0.81915956
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.81700832
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80475987
120GATA3_26560356_Chip-Seq_TH2_Human0.79951057
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79804222
122WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79523100
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.79062986
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78800634
125CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77587768
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77054213
127AR_25329375_ChIP-Seq_VCAP_Human0.76874149
128ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76621438
129ESR1_21235772_ChIP-Seq_MCF-7_Human0.76418223
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76398511
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76338009
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.76070284
133GATA3_27048872_Chip-Seq_THYMUS_Human0.75956095
134LXR_22292898_ChIP-Seq_THP-1_Human0.75744357
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75671001
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75005856
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.74575699
138* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.74425356
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73508710
140PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.72836384
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.71818511
142TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.71045301
143SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.70688863
144KDM2B_26808549_Chip-Seq_DND41_Human0.70099546
145AHR_22903824_ChIP-Seq_MCF-7_Human0.69986626
146MYB_26560356_Chip-Seq_TH1_Human0.69947997
147* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.69775414
148UTX_26944678_Chip-Seq_JUKART_Human0.69680833
149FOXO3_23340844_ChIP-Seq_DLD1_Human0.68760308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol6.95002429
2MP0006082_CNS_inflammation6.53687585
3MP0005058_abnormal_lysosome_morphology5.11289023
4MP0003690_abnormal_glial_cell4.90693286
5MP0003172_abnormal_lysosome_physiology3.81644056
6MP0001835_abnormal_antigen_presentation3.31384295
7MP0004883_abnormal_blood_vessel3.21704593
8MP0005671_abnormal_response_to3.19232111
9MP0003075_altered_response_to2.84183036
10MP0003303_peritoneal_inflammation2.74758067
11MP0003252_abnormal_bile_duct2.63377135
12* MP0005464_abnormal_platelet_physiology2.37562381
13MP0009384_cardiac_valve_regurgitation2.36641398
14MP0008004_abnormal_stomach_pH2.25347881
15MP0003045_fibrosis2.15347863
16MP0005085_abnormal_gallbladder_physiolo2.14830966
17MP0002419_abnormal_innate_immunity1.98838026
18MP0001545_abnormal_hematopoietic_system1.96340801
19MP0005397_hematopoietic_system_phenotyp1.96340801
20MP0004145_abnormal_muscle_electrophysio1.93343971
21MP0002148_abnormal_hypersensitivity_rea1.89719892
22MP0004130_abnormal_muscle_cell1.83868284
23MP0005166_decreased_susceptibility_to1.83550030
24MP0005164_abnormal_response_to1.72079846
25MP0009840_abnormal_foam_cell1.70800863
26MP0001851_eye_inflammation1.70382379
27MP0009278_abnormal_bone_marrow1.69752039
28MP0009333_abnormal_splenocyte_physiolog1.68763790
29MP0002452_abnormal_antigen_presenting1.64792822
30MP0003879_abnormal_hair_cell1.63212043
31MP0000685_abnormal_immune_system1.58640616
32MP0005387_immune_system_phenotype1.54493781
33MP0001790_abnormal_immune_system1.54493781
34MP0005000_abnormal_immune_tolerance1.50946323
35MP0003566_abnormal_cell_adhesion1.50033634
36MP0000920_abnormal_myelination1.49253443
37MP0004036_abnormal_muscle_relaxation1.47729467
38MP0001915_intracranial_hemorrhage1.46823512
39MP0008007_abnormal_cellular_replicative1.45647491
40MP0005670_abnormal_white_adipose1.43498069
41MP0002723_abnormal_immune_serum1.40174967
42MP0002090_abnormal_vision1.36712143
43MP0003638_abnormal_response/metabolism_1.35011901
44MP0000249_abnormal_blood_vessel1.34016404
45MP0005646_abnormal_pituitary_gland1.33527942
46MP0003724_increased_susceptibility_to1.30778791
47MP0004947_skin_inflammation1.30552920
48MP0003436_decreased_susceptibility_to1.28818210
49MP0009763_increased_sensitivity_to1.27616322
50MP0001819_abnormal_immune_cell1.27480153
51MP0010155_abnormal_intestine_physiology1.27130416
52MP0005083_abnormal_biliary_tract1.25470221
53MP0001968_abnormal_touch/_nociception1.25007309
54MP0001800_abnormal_humoral_immune1.24626070
55MP0002420_abnormal_adaptive_immunity1.23795727
56MP0005167_abnormal_blood-brain_barrier1.23490457
57MP0003300_gastrointestinal_ulcer1.21908256
58MP0001533_abnormal_skeleton_physiology1.21393948
59MP0008775_abnormal_heart_ventricle1.20878843
60MP0004084_abnormal_cardiac_muscle1.20539354
61MP0002254_reproductive_system_inflammat1.20288659
62MP0009785_altered_susceptibility_to1.18251829
63MP0002733_abnormal_thermal_nociception1.15032574
64MP0008874_decreased_physiological_sensi1.14423019
65MP0008469_abnormal_protein_level1.12054641
66MP0001663_abnormal_digestive_system1.11813867
67MP0003866_abnormal_defecation1.10650248
68MP0000343_altered_response_to1.10438496
69MP0005165_increased_susceptibility_to1.10234361
70MP0004484_altered_response_of1.08917782
71MP0003195_calcinosis1.08571806
72MP0009764_decreased_sensitivity_to1.08379106
73MP0001986_abnormal_taste_sensitivity1.06146502
74MP0010329_abnormal_lipoprotein_level1.05959254
75MP0003183_abnormal_peptide_metabolism1.05169564
76MP0009053_abnormal_anal_canal1.02691166
77MP0001970_abnormal_pain_threshold1.02508777
78MP0005171_absent_coat_pigmentation1.01703936
79MP0003634_abnormal_glial_cell1.01451239
80MP0002998_abnormal_bone_remodeling1.00995921
81MP0002928_abnormal_bile_duct1.00110569
82MP0004270_analgesia0.99425430
83MP0000767_abnormal_smooth_muscle0.99124500
84MP0006138_congestive_heart_failure0.99020083
85MP0005025_abnormal_response_to0.98155048
86MP0000858_altered_metastatic_potential0.97898475
87MP0004185_abnormal_adipocyte_glucose0.95153368
88MP0001879_abnormal_lymphatic_vessel0.93634917
89MP0003279_aneurysm0.90851658
90MP0003828_pulmonary_edema0.90280098
91MP0003329_amyloid_beta_deposits0.89691630
92MP0003633_abnormal_nervous_system0.89484097
93MP0008873_increased_physiological_sensi0.88061271
94MP0001845_abnormal_inflammatory_respons0.87505048
95MP0000716_abnormal_immune_system0.84559728
96MP0002736_abnormal_nociception_after0.83196947
97MP0006276_abnormal_autonomic_nervous0.81892203
98MP0005023_abnormal_wound_healing0.80787606
99MP0001765_abnormal_ion_homeostasis0.80153985
100MP0005410_abnormal_fertilization0.77603425
101MP0005535_abnormal_body_temperature0.77402860
102MP0000689_abnormal_spleen_morphology0.77290056
103MP0003091_abnormal_cell_migration0.76453237
104MP0001661_extended_life_span0.76354506
105MP0001873_stomach_inflammation0.76283640
106MP0000465_gastrointestinal_hemorrhage0.75480204
107MP0004510_myositis0.74472361
108MP0000015_abnormal_ear_pigmentation0.73850874
109MP0005197_abnormal_uvea_morphology0.73218074
110MP0005595_abnormal_vascular_smooth0.71709842
111MP0002971_abnormal_brown_adipose0.71084331
112MP0002735_abnormal_chemical_nociception0.70221089
113MP0001764_abnormal_homeostasis0.68925206
114MP0005310_abnormal_salivary_gland0.68013716
115MP0005647_abnormal_sex_gland0.67786782
116* MP0009642_abnormal_blood_homeostasis0.66174863
117MP0005381_digestive/alimentary_phenotyp0.65643974
118MP0005174_abnormal_tail_pigmentation0.65384331
119MP0005376_homeostasis/metabolism_phenot0.65236958
120MP0002933_joint_inflammation0.64913785
121MP0003136_yellow_coat_color0.64692193
122MP0004859_abnormal_synaptic_plasticity0.64274568
123MP0002429_abnormal_blood_cell0.64150864
124MP0003795_abnormal_bone_structure0.63755273
125MP0002064_seizures0.62292917
126MP0002722_abnormal_immune_system0.61853332
127MP0000609_abnormal_liver_physiology0.61283582
128MP0005666_abnormal_adipose_tissue0.61146521
129MP0002405_respiratory_system_inflammati0.60073076
130MP0002398_abnormal_bone_marrow0.59031821
131MP0003656_abnormal_erythrocyte_physiolo0.57397386
132MP0001849_ear_inflammation0.57275995
133MP0002396_abnormal_hematopoietic_system0.55757231
134MP0002229_neurodegeneration0.55031654
135MP0005409_darkened_coat_color0.52926937
136MP0000230_abnormal_systemic_arterial0.52728204
137MP0001542_abnormal_bone_strength0.49169903
138MP0008872_abnormal_physiological_respon0.48476945
139MP0003943_abnormal_hepatobiliary_system0.48414694
140MP0002557_abnormal_social/conspecific_i0.48082793
141MP0003631_nervous_system_phenotype0.48054040
142MP0010368_abnormal_lymphatic_system0.46933504
143MP0003453_abnormal_keratinocyte_physiol0.45898939
144MP0005334_abnormal_fat_pad0.45587738

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.00391147
2Menorrhagia (HP:0000132)8.94801374
3Abnormal platelet volume (HP:0011876)8.57228290
4Petechiae (HP:0000967)8.47057618
5Purpura (HP:0000979)8.25817921
6Abnormality of glycolipid metabolism (HP:0010969)7.89735345
7Abnormality of liposaccharide metabolism (HP:0010968)7.89735345
8Abnormality of glycosphingolipid metabolism (HP:0004343)7.89735345
9Systemic lupus erythematosus (HP:0002725)7.71566766
10Glomerulonephritis (HP:0000099)7.20878090
11* Epistaxis (HP:0000421)6.53899577
12Gingival bleeding (HP:0000225)6.49637073
13Arterial tortuosity (HP:0005116)5.92174135
14Complement deficiency (HP:0004431)5.89803842
15Urethral obstruction (HP:0000796)5.46417572
16Spontaneous hematomas (HP:0007420)5.22859748
17Vascular tortuosity (HP:0004948)5.20488551
18Dysostosis multiplex (HP:0000943)5.11968539
19Hyperlipoproteinemia (HP:0010980)5.08282534
20J-shaped sella turcica (HP:0002680)4.39986232
21Orthostatic hypotension (HP:0001278)4.31000497
22Abnormality of complement system (HP:0005339)4.18878081
23Progressive neurologic deterioration (HP:0002344)4.17961554
24Chronic diarrhea (HP:0002028)3.96166101
25Mutism (HP:0002300)3.92323886
26Cerebral aneurysm (HP:0004944)3.91755611
27Spondylolisthesis (HP:0003302)3.90954481
28Aortic aneurysm (HP:0004942)3.88106385
29Retinal atrophy (HP:0001105)3.83357512
30Hepatosplenomegaly (HP:0001433)3.72203988
31Intestinal atresia (HP:0011100)3.66420240
32Split foot (HP:0001839)3.64730707
33Broad face (HP:0000283)3.64431439
34* Impaired platelet aggregation (HP:0003540)3.58911166
35* Abnormal platelet function (HP:0011869)3.58911166
36Nephritis (HP:0000123)3.58505433
37Recurrent bacterial skin infections (HP:0005406)3.55075895
38Poikilocytosis (HP:0004447)3.54892082
39Conjunctival telangiectasia (HP:0000524)3.53648141
40Urinary glycosaminoglycan excretion (HP:0003541)3.45179039
41Mucopolysacchariduria (HP:0008155)3.45179039
42Acanthocytosis (HP:0001927)3.41193350
43Dyschromatopsia (HP:0007641)3.36489063
44Partial duplication of thumb phalanx (HP:0009944)3.36205575
45Obstructive sleep apnea (HP:0002870)3.30908571
46Axonal loss (HP:0003447)3.25389265
47Hematochezia (HP:0002573)3.24177881
48Abnormality of mucopolysaccharide metabolism (HP:0011020)3.22310979
49Abnormality of polysaccharide metabolism (HP:0011012)3.22310979
50Abnormality of glycosaminoglycan metabolism (HP:0004371)3.22310979
51Recurrent abscess formation (HP:0002722)3.21870008
52Striae distensae (HP:0001065)3.20093143
53Abnormality of the vasculature of the conjunctiva (HP:0008054)3.19771424
54Rectovaginal fistula (HP:0000143)3.12372235
55Rectal fistula (HP:0100590)3.12372235
56Vacuolated lymphocytes (HP:0001922)3.07427801
57Increased cerebral lipofuscin (HP:0011813)3.04961219
58Upper motor neuron abnormality (HP:0002127)3.04498649
59Aortic dissection (HP:0002647)3.04051359
60Abnormality of the common coagulation pathway (HP:0010990)3.02367372
61Intestinal fistula (HP:0100819)2.99498891
62Increased neuronal autofluorescent lipopigment (HP:0002074)2.99022047
63Eczematoid dermatitis (HP:0000976)2.98768444
64Cervical subluxation (HP:0003308)2.98199881
65* Bruising susceptibility (HP:0000978)2.97087162
66Partial duplication of the phalanx of hand (HP:0009999)2.92846387
67Disproportionate tall stature (HP:0001519)2.81774859
68Lower limb asymmetry (HP:0100559)2.78082638
69Colitis (HP:0002583)2.77152854
70Abnormality of macrophages (HP:0004311)2.76683435
71Amyloidosis (HP:0011034)2.74390778
72Vaginal fistula (HP:0004320)2.72687682
73Flared iliac wings (HP:0002869)2.72495680
74Xanthomatosis (HP:0000991)2.68230890
75Deformed sella turcica (HP:0002681)2.66990306
76Disinhibition (HP:0000734)2.66633057
77Abnormal pupillary function (HP:0007686)2.52269450
78Agnosia (HP:0010524)2.49583288
79Paralysis (HP:0003470)2.47970252
80Increased density of long bones (HP:0006392)2.42617499
81Abnormal auditory evoked potentials (HP:0006958)2.42369658
82Cardiomegaly (HP:0001640)2.42175364
83Basal ganglia calcification (HP:0002135)2.35073750
84Abnormality of lateral ventricle (HP:0030047)2.33856676
85Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.33263138
86Arnold-Chiari malformation (HP:0002308)2.32841146
87Diplopia (HP:0000651)2.32411491
88Abnormality of binocular vision (HP:0011514)2.32411491
89Cerebral palsy (HP:0100021)2.30676010
90Stomatitis (HP:0010280)2.30271229
91Encephalitis (HP:0002383)2.28342143
92Mitral stenosis (HP:0001718)2.26413725
93Abnormality of the heme biosynthetic pathway (HP:0010472)2.26062142
94Arterial thrombosis (HP:0004420)2.19619044
95Abnormality of iron homeostasis (HP:0011031)2.19572240
96Abnormality of the sella turcica (HP:0002679)2.18723193
97Decreased central vision (HP:0007663)2.17231585
98Neuronal loss in central nervous system (HP:0002529)2.15653218
99Camptodactyly of toe (HP:0001836)2.12681160
100Inflammation of the large intestine (HP:0002037)2.09586207
101Joint swelling (HP:0001386)2.07916914
102Vertigo (HP:0002321)2.06255233
103Panhypogammaglobulinemia (HP:0003139)2.03004134
104Recurrent cutaneous fungal infections (HP:0011370)2.02933334
105Chronic mucocutaneous candidiasis (HP:0002728)2.02933334
106Thoracic kyphosis (HP:0002942)2.02785619
107Ventricular fibrillation (HP:0001663)2.02701958
108Aortic regurgitation (HP:0001659)2.02639077
109Joint hemorrhage (HP:0005261)1.99171213
110Tinnitus (HP:0000360)1.98930668
111Myocardial infarction (HP:0001658)1.94939636
112Erectile abnormalities (HP:0100639)1.94364493
113Chronic obstructive pulmonary disease (HP:0006510)1.93888919
114Obstructive lung disease (HP:0006536)1.93888919
115Spontaneous abortion (HP:0005268)1.93478210
116Recurrent skin infections (HP:0001581)1.93405545
117Upper limb muscle weakness (HP:0003484)1.92584910
118Thick nail (HP:0001805)1.92554012
119Urinary incontinence (HP:0000020)1.91949374
120Joint stiffness (HP:0001387)1.90233033
121Pathologic fracture (HP:0002756)1.89523880
122Hypoplasia of the odontoid process (HP:0003311)1.88823642
123Mitral valve prolapse (HP:0001634)1.87802931
124Abnormal autonomic nervous system physiology (HP:0012332)1.87697657
125Gastrointestinal inflammation (HP:0004386)1.86460566
126Abnormality of transition element cation homeostasis (HP:0011030)1.85876569
127Recurrent fungal infections (HP:0002841)1.85455174
128Myositis (HP:0100614)1.84186519
129Facial diplegia (HP:0001349)1.77531733
130Papillary thyroid carcinoma (HP:0002895)1.77412967
131Back pain (HP:0003418)1.75921738
132Chest pain (HP:0100749)1.75565186
133Episodic fever (HP:0001954)1.75302735
134Gastrointestinal atresia (HP:0002589)1.74850199
135Bladder carcinoma (HP:0002862)1.74137845
136Bladder neoplasm (HP:0009725)1.74137845
137Recurrent gram-negative bacterial infections (HP:0005420)1.72589573
138Prolonged bleeding time (HP:0003010)1.72479282
139Polygenic inheritance (HP:0010982)1.70655908
140Abnormality of the prostate (HP:0008775)1.68977990
141Polyphagia (HP:0002591)1.68464366
142Transitional cell carcinoma of the bladder (HP:0006740)1.67779748
143Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.67728487
144Anal stenosis (HP:0002025)1.67321718
145Orchitis (HP:0100796)1.66762044
146Macroglossia (HP:0000158)1.66511796
147Elevated erythrocyte sedimentation rate (HP:0003565)1.66258436
148Thickened calvaria (HP:0002684)1.64437519
149Increased IgM level (HP:0003496)1.63780880
150Postural instability (HP:0002172)1.63206692
151Osteolytic defects of the phalanges of the hand (HP:0009771)1.62152203
152Osteolytic defects of the hand bones (HP:0009699)1.62152203
153Hemiplegia (HP:0002301)1.62013685
154Inappropriate behavior (HP:0000719)1.61313962
155Nausea (HP:0002018)1.60598666
156Biconcave vertebral bodies (HP:0004586)1.60437629
157Meningitis (HP:0001287)1.60380483
158Abnormality of the odontoid process (HP:0003310)1.60070180
159Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.60061847
160Osteomyelitis (HP:0002754)1.59473352
161Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.58550070
162Leiomyosarcoma (HP:0100243)1.57602732
163Uterine leiomyosarcoma (HP:0002891)1.57602732
164Increased serum ferritin (HP:0003281)1.55769735
165Mediastinal lymphadenopathy (HP:0100721)1.55411680
166Leukocytosis (HP:0001974)1.55215622
167Centrally nucleated skeletal muscle fibers (HP:0003687)1.55057974
168Dementia (HP:0000726)1.53733913
169Peripheral demyelination (HP:0011096)1.53518331
170Periauricular skin pits (HP:0100277)1.52446018
171Preauricular pit (HP:0004467)1.52446018
172Male infertility (HP:0003251)1.51374511
173Arthralgia (HP:0002829)1.51282982
174Febrile seizures (HP:0002373)1.50259819
175Pulmonary embolism (HP:0002204)1.49974199
176Agammaglobulinemia (HP:0004432)1.49215647
177Distal lower limb amyotrophy (HP:0008944)1.47288821
178Thrombocytosis (HP:0001894)1.47231835
179Memory impairment (HP:0002354)1.45974265
180Mucosal telangiectasiae (HP:0100579)1.45653233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR28.65616699
2PDK25.53015904
3GRK75.16026791
4BMX3.62715900
5MST43.30488147
6MAPK152.99740497
7TEC2.95334269
8NEK92.88462733
9BTK2.83197037
10CSF1R2.75766610
11MOS2.48488842
12MYLK2.29350487
13MAPK72.27191861
14TAOK32.19552112
15STK102.17567875
16TYK22.07882005
17GRK52.06527311
18ARAF2.04825221
19CDK81.95651349
20MAPK121.90130133
21TNK21.88852733
22PTK2B1.88435078
23FGR1.83397694
24NEK61.78307552
25MATK1.75005025
26EIF2AK11.74077698
27ERN11.72928076
28RIPK41.62623187
29TSSK61.50728442
30TXK1.40350241
31JAK11.31909894
32PKN21.31355972
33CLK11.30020716
34PDK11.25529075
35MAP3K91.20504916
36JAK31.18329965
37STK31.11795422
38KIT1.09321509
39GRK61.06289522
40JAK21.05904775
41ILK1.05768556
42SGK21.03181939
43ZAP701.01836435
44IRAK10.99942430
45RET0.98547507
46PNCK0.97777955
47IKBKB0.95051033
48BLK0.92433758
49TBK10.91879401
50PIM20.91712398
51MAP4K10.89784960
52EIF2AK20.88989011
53PLK20.86832147
54IRAK40.85820159
55PAK40.84449428
56MAP2K10.83443417
57CAMKK10.83237509
58MAP3K60.82610473
59EPHA30.82267921
60PDGFRB0.81174664
61PAK10.78797301
62ERBB20.78695808
63MAP3K50.74118449
64LYN0.73641331
65CAMK1D0.73112334
66CSK0.70902008
67PDPK10.70248039
68CDK30.69824732
69NTRK30.67006282
70STK240.64731145
71RPS6KA20.64019789
72YES10.63596875
73PRKACG0.63230685
74PAK20.62525636
75MAPKAPK50.62062179
76HCK0.61452849
77MAPKAPK30.60332483
78CDK90.59072285
79DAPK20.59061962
80NTRK20.58208463
81MAPKAPK20.57825213
82IGF1R0.56196287
83ADRBK20.55970176
84BMPR20.54869034
85IRAK20.53802011
86MELK0.53566401
87DAPK30.50507447
88RPS6KL10.50239243
89RPS6KC10.50239243
90CAMK40.49674193
91MAP2K30.49580608
92ACVR1B0.49493756
93TNIK0.48999484
94FGFR40.48600343
95SGK4940.48126368
96SGK2230.48126368
97LCK0.47091647
98CAMK10.46527554
99EEF2K0.45980034
100RPS6KA60.45866643
101PIK3CG0.45578866
102FES0.43436642
103FER0.42975334
104FLT30.42624238
105MINK10.42467548
106IKBKE0.42040455
107ROCK10.41914857
108MARK30.40349591
109PRKAA20.40085667
110SYK0.38816623
111RAF10.38812588
112FGFR30.37613808
113CAMK2G0.37376899
114CAMK1G0.37243029
115PAK30.37035161
116STK40.36748648
117ROCK20.36595315
118CDK60.36453124
119MAP3K70.36426244
120EPHB20.35589961
121ITK0.34840677
122MARK20.34469672
123MAPK130.34420241
124CDC42BPA0.33270660
125RPS6KA40.32723957
126PRKCD0.32570176
127LMTK20.31593937
128PRKG10.31442011
129MAP3K10.30999004
130SIK20.30710666
131KSR20.30537904
132CAMKK20.30400588
133MAP3K140.29556504
134PKN10.29169398
135TRIB30.27689676
136EGFR0.27480716
137SGK30.26881972
138MAPK40.25899227
139INSR0.24991205
140PTK60.23834723
141MAP2K20.23495257
142VRK10.23420201
143EPHB10.22533167
144GSK3A0.20739689
145TGFBR10.17928080
146MAP2K40.17785171
147INSRR0.16015457
148ADRBK10.15774552
149PDGFRA0.14910877
150HIPK20.14279967
151PRKD10.14247266
152FYN0.12607132
153MAP2K60.12285656

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005315.41392201
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.98612716
3Other glycan degradation_Homo sapiens_hsa005114.89635087
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.76531893
5Staphylococcus aureus infection_Homo sapiens_hsa051504.48486543
6Lysosome_Homo sapiens_hsa041422.91730301
7Ether lipid metabolism_Homo sapiens_hsa005652.34081270
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.21668741
9Osteoclast differentiation_Homo sapiens_hsa043802.04198039
10Prion diseases_Homo sapiens_hsa050201.87300927
11Leishmaniasis_Homo sapiens_hsa051401.81894692
12SNARE interactions in vesicular transport_Homo sapiens_hsa041301.78337064
13B cell receptor signaling pathway_Homo sapiens_hsa046621.76207682
14Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.74223148
15Systemic lupus erythematosus_Homo sapiens_hsa053221.55751405
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.46420989
17Serotonergic synapse_Homo sapiens_hsa047261.45557533
18Pertussis_Homo sapiens_hsa051331.45288170
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41894399
20ECM-receptor interaction_Homo sapiens_hsa045121.32995659
21Circadian entrainment_Homo sapiens_hsa047131.30133052
22Pancreatic secretion_Homo sapiens_hsa049721.27079604
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26494027
24Antigen processing and presentation_Homo sapiens_hsa046121.25965364
25Pancreatic cancer_Homo sapiens_hsa052121.21907608
26Toxoplasmosis_Homo sapiens_hsa051451.19957485
27Nitrogen metabolism_Homo sapiens_hsa009101.16996323
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14825246
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14178237
30Complement and coagulation cascades_Homo sapiens_hsa046101.14067096
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12405229
32Morphine addiction_Homo sapiens_hsa050321.12084121
33Gastric acid secretion_Homo sapiens_hsa049711.11535759
34Chronic myeloid leukemia_Homo sapiens_hsa052201.11510657
35Renin secretion_Homo sapiens_hsa049241.11033010
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06184929
37Chemokine signaling pathway_Homo sapiens_hsa040621.02647392
38Tuberculosis_Homo sapiens_hsa051521.01828501
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00912665
40NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99080598
41Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97826776
42Cholinergic synapse_Homo sapiens_hsa047250.95899683
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93207937
44Alcoholism_Homo sapiens_hsa050340.93108235
45* Platelet activation_Homo sapiens_hsa046110.92181524
46Collecting duct acid secretion_Homo sapiens_hsa049660.90982151
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.88081711
48Long-term potentiation_Homo sapiens_hsa047200.87049485
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86502167
50Salmonella infection_Homo sapiens_hsa051320.84985724
51GABAergic synapse_Homo sapiens_hsa047270.84535862
52Legionellosis_Homo sapiens_hsa051340.83422081
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83270878
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82847465
55Glycerolipid metabolism_Homo sapiens_hsa005610.82331008
56Arachidonic acid metabolism_Homo sapiens_hsa005900.77269343
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76809914
58Salivary secretion_Homo sapiens_hsa049700.76080539
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73973384
60Hematopoietic cell lineage_Homo sapiens_hsa046400.67175025
61Colorectal cancer_Homo sapiens_hsa052100.66902282
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66285971
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66020042
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65889700
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65231105
66Graft-versus-host disease_Homo sapiens_hsa053320.64478507
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64419823
68Primary immunodeficiency_Homo sapiens_hsa053400.63349518
69MAPK signaling pathway_Homo sapiens_hsa040100.62743595
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62145005
71Estrogen signaling pathway_Homo sapiens_hsa049150.62096319
72Focal adhesion_Homo sapiens_hsa045100.60078281
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.59948275
74Asthma_Homo sapiens_hsa053100.59014187
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.58648812
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58283969
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.57413946
78Olfactory transduction_Homo sapiens_hsa047400.56948468
79VEGF signaling pathway_Homo sapiens_hsa043700.55885440
80Apoptosis_Homo sapiens_hsa042100.55754478
81GnRH signaling pathway_Homo sapiens_hsa049120.55418990
82Endocytosis_Homo sapiens_hsa041440.55117441
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54786219
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53535231
85Allograft rejection_Homo sapiens_hsa053300.53357193
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.53133003
87Renal cell carcinoma_Homo sapiens_hsa052110.52839969
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52450932
89Influenza A_Homo sapiens_hsa051640.51404223
90Endometrial cancer_Homo sapiens_hsa052130.51113589
91Hepatitis B_Homo sapiens_hsa051610.49190260
92Amoebiasis_Homo sapiens_hsa051460.49063476
93Autoimmune thyroid disease_Homo sapiens_hsa053200.48533874
94PPAR signaling pathway_Homo sapiens_hsa033200.48372070
95TNF signaling pathway_Homo sapiens_hsa046680.47630336
96cAMP signaling pathway_Homo sapiens_hsa040240.47213204
97T cell receptor signaling pathway_Homo sapiens_hsa046600.46996258
98Dorso-ventral axis formation_Homo sapiens_hsa043200.46622252
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.46360881
100Linoleic acid metabolism_Homo sapiens_hsa005910.45522223
101ABC transporters_Homo sapiens_hsa020100.45025668
102Viral carcinogenesis_Homo sapiens_hsa052030.44332219
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44178163
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.43252775
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42989263
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.42717150
107Non-small cell lung cancer_Homo sapiens_hsa052230.41998499
108African trypanosomiasis_Homo sapiens_hsa051430.39842077
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39817281
110Phagosome_Homo sapiens_hsa041450.38961196
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38910905
112Oxytocin signaling pathway_Homo sapiens_hsa049210.38411649
113Rheumatoid arthritis_Homo sapiens_hsa053230.38041479
114Measles_Homo sapiens_hsa051620.36235464
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35906009
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35539481
117FoxO signaling pathway_Homo sapiens_hsa040680.35072674
118Chemical carcinogenesis_Homo sapiens_hsa052040.33502227
119N-Glycan biosynthesis_Homo sapiens_hsa005100.32160633
120Adherens junction_Homo sapiens_hsa045200.32144279
121Cocaine addiction_Homo sapiens_hsa050300.31762342
122Gap junction_Homo sapiens_hsa045400.30541166
123Glioma_Homo sapiens_hsa052140.28242263
124Choline metabolism in cancer_Homo sapiens_hsa052310.27313567
125Acute myeloid leukemia_Homo sapiens_hsa052210.27229032
126Long-term depression_Homo sapiens_hsa047300.27016725
127Rap1 signaling pathway_Homo sapiens_hsa040150.26988680
128Ras signaling pathway_Homo sapiens_hsa040140.26485174
129Malaria_Homo sapiens_hsa051440.25024863
130Calcium signaling pathway_Homo sapiens_hsa040200.24656901
131Glutamatergic synapse_Homo sapiens_hsa047240.24565811
132Notch signaling pathway_Homo sapiens_hsa043300.22824980
133ErbB signaling pathway_Homo sapiens_hsa040120.22821916
134Shigellosis_Homo sapiens_hsa051310.21828796
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21628279
136Inositol phosphate metabolism_Homo sapiens_hsa005620.20910635
137Starch and sucrose metabolism_Homo sapiens_hsa005000.20494345

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