P2RY4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indole-containing compound catabolic process (GO:0042436)5.87991333
2indolalkylamine catabolic process (GO:0046218)5.87991333
3tryptophan catabolic process (GO:0006569)5.87991333
4aromatic amino acid family catabolic process (GO:0009074)5.57411299
5tryptophan metabolic process (GO:0006568)5.36175172
6L-phenylalanine catabolic process (GO:0006559)5.23931437
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.23931437
8cellular biogenic amine catabolic process (GO:0042402)4.79770504
9amine catabolic process (GO:0009310)4.79770504
10kynurenine metabolic process (GO:0070189)4.79289306
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.64781023
12L-phenylalanine metabolic process (GO:0006558)4.64781023
13NAD biosynthetic process (GO:0009435)4.42408754
14indolalkylamine metabolic process (GO:0006586)4.37888833
15regulation of fibrinolysis (GO:0051917)4.12330663
16phospholipid efflux (GO:0033700)4.11929288
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.09493656
18high-density lipoprotein particle remodeling (GO:0034375)4.05197986
19bile acid biosynthetic process (GO:0006699)4.04543937
20aromatic amino acid family metabolic process (GO:0009072)4.02667807
21blood coagulation, intrinsic pathway (GO:0007597)3.97534060
22urea cycle (GO:0000050)3.92334395
23urea metabolic process (GO:0019627)3.92334395
24regulation of cholesterol esterification (GO:0010872)3.90132281
25tyrosine metabolic process (GO:0006570)3.77525888
26glyoxylate metabolic process (GO:0046487)3.74998223
27nitrogen cycle metabolic process (GO:0071941)3.67911308
28bile acid and bile salt transport (GO:0015721)3.65168301
29bile acid metabolic process (GO:0008206)3.60211337
30low-density lipoprotein particle remodeling (GO:0034374)3.55689822
31imidazole-containing compound metabolic process (GO:0052803)3.54116275
32negative regulation of lipase activity (GO:0060192)3.53974151
33nicotinamide nucleotide biosynthetic process (GO:0019359)3.53758942
34pyridine nucleotide biosynthetic process (GO:0019363)3.53758942
35protein carboxylation (GO:0018214)3.50940003
36peptidyl-glutamic acid carboxylation (GO:0017187)3.50940003
37cellular glucuronidation (GO:0052695)3.48806815
38plasma lipoprotein particle remodeling (GO:0034369)3.44160709
39protein-lipid complex remodeling (GO:0034368)3.44160709
40macromolecular complex remodeling (GO:0034367)3.44160709
41homocysteine metabolic process (GO:0050667)3.43426933
42serine family amino acid catabolic process (GO:0009071)3.41788948
43aldehyde catabolic process (GO:0046185)3.41539716
44triglyceride homeostasis (GO:0070328)3.34415723
45acylglycerol homeostasis (GO:0055090)3.34415723
46regulation of protein activation cascade (GO:2000257)3.34214576
47complement activation, alternative pathway (GO:0006957)3.33243803
48arginine metabolic process (GO:0006525)3.29811650
49amino-acid betaine metabolic process (GO:0006577)3.27637806
50regulation of activation of Janus kinase activity (GO:0010533)3.25729817
51cholesterol efflux (GO:0033344)3.25406121
52reverse cholesterol transport (GO:0043691)3.24857918
53negative regulation of fibrinolysis (GO:0051918)3.23713959
54alpha-amino acid catabolic process (GO:1901606)3.21818326
55uronic acid metabolic process (GO:0006063)3.21210877
56glucuronate metabolic process (GO:0019585)3.21210877
57fibrinolysis (GO:0042730)3.17239814
58coenzyme catabolic process (GO:0009109)3.12391986
59benzene-containing compound metabolic process (GO:0042537)3.08621778
60nucleotide transmembrane transport (GO:1901679)3.07040831
61regulation of complement activation (GO:0030449)2.99418850
62linoleic acid metabolic process (GO:0043651)2.99008773
63regulation of bile acid biosynthetic process (GO:0070857)2.94838630
64indole-containing compound metabolic process (GO:0042430)2.92446865
65very-low-density lipoprotein particle assembly (GO:0034379)2.91276433
66omega-hydroxylase P450 pathway (GO:0097267)2.90995022
67protein activation cascade (GO:0072376)2.87578845
68polyol transport (GO:0015791)2.86549755
69fatty acid elongation (GO:0030497)2.81883746
70regulation of triglyceride catabolic process (GO:0010896)2.78469616
71superoxide anion generation (GO:0042554)2.78263148
72cellular amino acid catabolic process (GO:0009063)2.77486232
73cofactor catabolic process (GO:0051187)2.77468356
74detection of bacterium (GO:0016045)2.74870376
75drug catabolic process (GO:0042737)2.74308554
76positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.71595663
77arginine catabolic process (GO:0006527)2.69966936
78fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.68745201
79androgen biosynthetic process (GO:0006702)2.68692273
80opsonization (GO:0008228)2.68244169
81negative regulation of sterol transport (GO:0032372)2.67623096
82negative regulation of cholesterol transport (GO:0032375)2.67623096
83intestinal cholesterol absorption (GO:0030299)2.67560622
84sulfur amino acid catabolic process (GO:0000098)2.63005929
85pyrimidine nucleobase catabolic process (GO:0006208)2.62731274
86negative regulation of blood coagulation (GO:0030195)2.61505698
87negative regulation of hemostasis (GO:1900047)2.61505698
88positive regulation of cellular amine metabolic process (GO:0033240)2.61146349
89regulation of phospholipase A2 activity (GO:0032429)2.60997101
90pyrimidine nucleoside catabolic process (GO:0046135)2.58036299
91pyridine-containing compound biosynthetic process (GO:0072525)2.56775314
92detection of other organism (GO:0098543)2.56485326
93plasma lipoprotein particle assembly (GO:0034377)2.55522259
94regulation of interleukin-8 secretion (GO:2000482)2.54870030
95cellular ketone body metabolic process (GO:0046950)2.50578407
96plasma lipoprotein particle organization (GO:0071827)2.50523427
97pyrimidine-containing compound transmembrane transport (GO:0072531)2.49165157
98plasma lipoprotein particle clearance (GO:0034381)2.48924720
99adenosine metabolic process (GO:0046085)2.48245829
100organic acid catabolic process (GO:0016054)2.47025351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse4.57081792
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.94495757
3GBX2_23144817_ChIP-Seq_PC3_Human3.17570006
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.84436326
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.66677886
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60919521
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.60223674
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.60132690
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.51005192
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43085175
11SUZ12_27294783_Chip-Seq_NPCs_Mouse2.39483982
12NFE2_27457419_Chip-Seq_LIVER_Mouse2.33358732
13TAF15_26573619_Chip-Seq_HEK293_Human2.32783370
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.30645264
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.29360949
16IRF1_19129219_ChIP-ChIP_H3396_Human2.16408269
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.11452835
18EZH2_22144423_ChIP-Seq_EOC_Human2.10375612
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.07979945
20VDR_22108803_ChIP-Seq_LS180_Human2.06196122
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03752977
22EZH2_27294783_Chip-Seq_NPCs_Mouse2.02417247
23EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.86020842
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.85430238
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81209213
26EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.80775053
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79998386
28P53_22387025_ChIP-Seq_ESCs_Mouse1.73867083
29RUNX1_27457419_Chip-Seq_LIVER_Mouse1.72465214
30NANOG_18555785_Chip-Seq_ESCs_Mouse1.71099348
31SUZ12_18555785_Chip-Seq_ESCs_Mouse1.70800855
32STAT3_18555785_Chip-Seq_ESCs_Mouse1.67821370
33P300_19829295_ChIP-Seq_ESCs_Human1.66731741
34E2F1_18555785_Chip-Seq_ESCs_Mouse1.66606954
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.65663452
36NMYC_18555785_Chip-Seq_ESCs_Mouse1.64529864
37P300_18555785_Chip-Seq_ESCs_Mouse1.64143259
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63362111
39* HTT_18923047_ChIP-ChIP_STHdh_Human1.62658502
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59391951
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54280619
42OCT4_18555785_Chip-Seq_ESCs_Mouse1.53825240
43PU1_27457419_Chip-Seq_LIVER_Mouse1.52152475
44CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.52047084
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50898158
46CMYC_18555785_Chip-Seq_ESCs_Mouse1.50687128
47SMAD1_18555785_Chip-Seq_ESCs_Mouse1.50280991
48ESRRB_18555785_Chip-Seq_ESCs_Mouse1.48963263
49SOX2_18555785_Chip-Seq_ESCs_Mouse1.48610671
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.47986136
51CRX_20693478_ChIP-Seq_RETINA_Mouse1.47824474
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47742853
53KLF4_18555785_Chip-Seq_ESCs_Mouse1.46592094
54ZFX_18555785_Chip-Seq_ESCs_Mouse1.44489101
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.41930351
56OCT4_21477851_ChIP-Seq_ESCs_Mouse1.38751549
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38304979
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.37689985
59CTCF_18555785_Chip-Seq_ESCs_Mouse1.36502531
60SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.32820453
61TAL1_26923725_Chip-Seq_HPCs_Mouse1.32206453
62KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32065613
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28052729
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27994653
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27989485
66IGF1R_20145208_ChIP-Seq_DFB_Human1.24413808
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20125942
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18941982
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.18719839
70* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17185563
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15768716
72TP53_18474530_ChIP-ChIP_U2OS_Human1.13951872
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13776208
74ER_23166858_ChIP-Seq_MCF-7_Human1.13772986
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.13639017
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13219411
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13219212
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13136624
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12915820
80RNF2_27304074_Chip-Seq_NSC_Mouse1.12311664
81SMAD4_21799915_ChIP-Seq_A2780_Human1.11531347
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11467876
83FUS_26573619_Chip-Seq_HEK293_Human1.08706420
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08335646
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07447433
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03766249
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.03123585
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.01912268
89SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01608550
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01540272
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99948334
92KDM2B_26808549_Chip-Seq_REH_Human0.97782665
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97751697
94STAT1_17558387_ChIP-Seq_HELA_Human0.96388702
95BCAT_22108803_ChIP-Seq_LS180_Human0.95457559
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95180907
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95180907
98PHF8_20622853_ChIP-Seq_HELA_Human0.94639462
99JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94544771
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93632416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.25659549
2MP0005360_urolithiasis4.97524442
3MP0005085_abnormal_gallbladder_physiolo4.58896731
4MP0005365_abnormal_bile_salt4.00126535
5MP0008875_abnormal_xenobiotic_pharmacok3.58144731
6MP0004381_abnormal_hair_follicle3.39468048
7MP0000566_synostosis3.23037242
8MP0006292_abnormal_olfactory_placode3.10300850
9MP0003195_calcinosis3.06071516
10MP0005451_abnormal_body_composition2.96736130
11MP0003941_abnormal_skin_development2.89010696
12MP0003252_abnormal_bile_duct2.70203250
13MP0002102_abnormal_ear_morphology2.45977556
14MP0004019_abnormal_vitamin_homeostasis2.30647591
15MP0002138_abnormal_hepatobiliary_system2.19968106
16MP0003136_yellow_coat_color2.16649889
17MP0001188_hyperpigmentation2.15783081
18MP0009697_abnormal_copulation2.08289591
19MP0010329_abnormal_lipoprotein_level1.90788275
20MP0005083_abnormal_biliary_tract1.86117701
21MP0003724_increased_susceptibility_to1.83901428
22MP0009379_abnormal_foot_pigmentation1.79412060
23MP0002876_abnormal_thyroid_physiology1.69094430
24MP0005075_abnormal_melanosome_morpholog1.66205050
25MP0005379_endocrine/exocrine_gland_phen1.61244260
26MP0004782_abnormal_surfactant_physiolog1.57437655
27MP0005332_abnormal_amino_acid1.54561598
28MP0009840_abnormal_foam_cell1.52768022
29MP0003011_delayed_dark_adaptation1.50590884
30MP0009764_decreased_sensitivity_to1.50498430
31MP0001666_abnormal_nutrient_absorption1.48256767
32MP0002132_abnormal_respiratory_system1.47627487
33MP0003806_abnormal_nucleotide_metabolis1.42269405
34MP0001764_abnormal_homeostasis1.35140604
35MP0003868_abnormal_feces_composition1.30984941
36MP0000579_abnormal_nail_morphology1.29213554
37MP0009785_altered_susceptibility_to1.27163563
38MP0005248_abnormal_Harderian_gland1.25096325
39MP0005647_abnormal_sex_gland1.23163933
40MP0003191_abnormal_cellular_cholesterol1.20695540
41MP0005084_abnormal_gallbladder_morpholo1.19971677
42MP0005409_darkened_coat_color1.19827494
43MP0002277_abnormal_respiratory_mucosa1.19485785
44MP0003718_maternal_effect1.14083653
45MP0010386_abnormal_urinary_bladder1.10654989
46MP0001835_abnormal_antigen_presentation1.08572482
47MP0002796_impaired_skin_barrier1.07803182
48MP0002118_abnormal_lipid_homeostasis1.04621371
49MP0005646_abnormal_pituitary_gland1.02249095
50MP0005408_hypopigmentation1.01003777
51MP0000015_abnormal_ear_pigmentation1.00612045
52MP0006276_abnormal_autonomic_nervous0.99558673
53MP0003938_abnormal_ear_development0.95853812
54MP0002163_abnormal_gland_morphology0.94454200
55MP0000613_abnormal_salivary_gland0.94429094
56MP0009765_abnormal_xenobiotic_induced0.91399535
57MP0000647_abnormal_sebaceous_gland0.90609702
58MP0001346_abnormal_lacrimal_gland0.90570471
59MP0002148_abnormal_hypersensitivity_rea0.89983350
60MP0000609_abnormal_liver_physiology0.88968661
61MP0000372_irregular_coat_pigmentation0.87948063
62MP0002638_abnormal_pupillary_reflex0.86918509
63MP0000026_abnormal_inner_ear0.86818843
64MP0003186_abnormal_redox_activity0.86241375
65MP0002098_abnormal_vibrissa_morphology0.85690355
66MP0001986_abnormal_taste_sensitivity0.84228977
67MP0005670_abnormal_white_adipose0.82803929
68MP0004142_abnormal_muscle_tone0.82435015
69MP0005174_abnormal_tail_pigmentation0.80796102
70MP0005171_absent_coat_pigmentation0.79969483
71MP0005645_abnormal_hypothalamus_physiol0.77623596
72MP0005671_abnormal_response_to0.76239108
73MP0005551_abnormal_eye_electrophysiolog0.76024860
74MP0009763_increased_sensitivity_to0.75758281
75MP0001790_abnormal_immune_system0.74871775
76MP0005387_immune_system_phenotype0.74871775
77MP0000427_abnormal_hair_cycle0.73160056
78MP0006082_CNS_inflammation0.72796357
79MP0008469_abnormal_protein_level0.72304015
80MP0002009_preneoplasia0.71528448
81MP0001984_abnormal_olfaction0.71155988
82MP0005025_abnormal_response_to0.70301035
83MP0002249_abnormal_larynx_morphology0.70217545
84MP0002254_reproductive_system_inflammat0.68472030
85MP0001486_abnormal_startle_reflex0.67899885
86MP0002060_abnormal_skin_morphology0.67653923
87MP0000538_abnormal_urinary_bladder0.66369529
88MP0002095_abnormal_skin_pigmentation0.65498659
89MP0001919_abnormal_reproductive_system0.65056925
90MP0005584_abnormal_enzyme/coenzyme_acti0.62091547
91MP0002419_abnormal_innate_immunity0.58339695
92MP0005319_abnormal_enzyme/_coenzyme0.58097526
93MP0004742_abnormal_vestibular_system0.56014574
94MP0005636_abnormal_mineral_homeostasis0.54804798
95MP0002938_white_spotting0.53826257
96MP0001324_abnormal_eye_pigmentation0.51494207
97MP0001853_heart_inflammation0.51211240
98MP0001177_atelectasis0.50507192
99MP0002177_abnormal_outer_ear0.49678858
100MP0003880_abnormal_central_pattern0.49306020

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)5.89812488
2Conjugated hyperbilirubinemia (HP:0002908)5.13975505
3Joint hemorrhage (HP:0005261)4.80308384
4Intrahepatic cholestasis (HP:0001406)4.28976440
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.01280646
6Abnormality of pyrimidine metabolism (HP:0004353)3.75067251
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.70531783
8Abnormality of methionine metabolism (HP:0010901)3.70007338
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.65904155
10Deep venous thrombosis (HP:0002625)3.61102297
11Epidermoid cyst (HP:0200040)3.42208371
12Hypobetalipoproteinemia (HP:0003563)3.35483487
13Abnormality of aspartate family amino acid metabolism (HP:0010899)3.30388949
14Renal cortical cysts (HP:0000803)3.23781355
15Chromsome breakage (HP:0040012)3.21678922
163-Methylglutaconic aciduria (HP:0003535)3.08610100
17Abnormality of the axillary hair (HP:0100134)3.02235345
18Abnormality of secondary sexual hair (HP:0009888)3.02235345
19Hypophosphatemic rickets (HP:0004912)2.92595485
20Xanthomatosis (HP:0000991)2.85076684
21Parakeratosis (HP:0001036)2.80648246
22Hyperglycinemia (HP:0002154)2.76088454
23Fat malabsorption (HP:0002630)2.68869249
24Fair hair (HP:0002286)2.65733997
25Abnormality of sulfur amino acid metabolism (HP:0004339)2.63640834
26Hyperlipoproteinemia (HP:0010980)2.54992849
27Duplicated collecting system (HP:0000081)2.48553792
28Complement deficiency (HP:0004431)2.48195478
29Renal Fanconi syndrome (HP:0001994)2.37041163
30Vascular calcification (HP:0004934)2.31898295
31Hypolipoproteinemia (HP:0010981)2.28730476
32Abnormality of serum amino acid levels (HP:0003112)2.27244632
33Methylmalonic acidemia (HP:0002912)2.26176135
34Abnormality of glutamine family amino acid metabolism (HP:0010902)2.25991765
35Abnormality of the renal collecting system (HP:0004742)2.25548672
36Conical tooth (HP:0000698)2.25063243
37Hypochromic microcytic anemia (HP:0004840)2.23423721
38Abnormality of the common coagulation pathway (HP:0010990)2.22896478
39Reticulocytopenia (HP:0001896)2.22596245
40Enlarged kidneys (HP:0000105)2.18670410
41Hyperglycinuria (HP:0003108)2.16735665
42Chronic hepatic failure (HP:0100626)2.15642027
43Abnormality of serine family amino acid metabolism (HP:0010894)2.14400514
44Abnormality of glycine metabolism (HP:0010895)2.14400514
45Steatorrhea (HP:0002570)2.09036260
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.08999593
47Hyperventilation (HP:0002883)2.08160592
48Recurrent gram-negative bacterial infections (HP:0005420)2.08052197
49Cerebral edema (HP:0002181)2.07578736
50Delayed CNS myelination (HP:0002188)2.06809677
51Menorrhagia (HP:0000132)2.06377325
52Dry hair (HP:0011359)2.03903942
53Abnormal biliary tract physiology (HP:0012439)2.03219168
54Bile duct proliferation (HP:0001408)2.03219168
55Pruritus (HP:0000989)2.03029052
56Hyperammonemia (HP:0001987)2.02275054
57Gingival bleeding (HP:0000225)2.01046371
58Rickets (HP:0002748)2.01027593
59Hyperbilirubinemia (HP:0002904)2.00719132
60Generalized hypopigmentation of hair (HP:0011358)2.00044165
61Decreased central vision (HP:0007663)1.98935717
62Osteomalacia (HP:0002749)1.97868682
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94233095
64Abnormality of the renal cortex (HP:0011035)1.92788205
65Metabolic acidosis (HP:0001942)1.92581927
66Hypercholesterolemia (HP:0003124)1.92414968
67Abnormality of urine glucose concentration (HP:0011016)1.91983403
68Glycosuria (HP:0003076)1.91983403
69Alveolar cell carcinoma (HP:0006519)1.91481341
70Prostate neoplasm (HP:0100787)1.91210686
71Lethargy (HP:0001254)1.91062194
72Renal tubular dysfunction (HP:0000124)1.87851914
73Gangrene (HP:0100758)1.87435847
74Hypoglycemic seizures (HP:0002173)1.87138875
75Hypoglycemic coma (HP:0001325)1.86332190
76Abnormality of homocysteine metabolism (HP:0010919)1.85129807
77Homocystinuria (HP:0002156)1.85129807
78Hypoalphalipoproteinemia (HP:0003233)1.84966559
79Cardiovascular calcification (HP:0011915)1.84623856
80Congenital ichthyosiform erythroderma (HP:0007431)1.83916838
81Symptomatic seizures (HP:0011145)1.82958852
82Microvesicular hepatic steatosis (HP:0001414)1.82020556
83Abnormality of nucleobase metabolism (HP:0010932)1.81759780
84Abnormality of complement system (HP:0005339)1.81387767
85Abnormality of the intrinsic pathway (HP:0010989)1.81375965
86Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81065808
87Dicarboxylic aciduria (HP:0003215)1.81065808
88Abnormality of vitamin metabolism (HP:0100508)1.78394918
89Glomerulonephritis (HP:0000099)1.78217069
90Cerebral palsy (HP:0100021)1.77377891
91Increased hepatocellular lipid droplets (HP:0006565)1.76367352
92Increased IgM level (HP:0003496)1.73651898
93Reduced antithrombin III activity (HP:0001976)1.73326419
94Abnormality of the prostate (HP:0008775)1.72452498
95Ketosis (HP:0001946)1.71279391
96Lipid accumulation in hepatocytes (HP:0006561)1.70079923
97Tubulointerstitial nephritis (HP:0001970)1.69650968
98Septo-optic dysplasia (HP:0100842)1.69521846
99Aplasia of the musculature (HP:0100854)1.69184651
100Abnormality of renal resorption (HP:0011038)1.68202577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.08368795
2CASK3.46769321
3INSRR2.85159460
4ZAK2.79378016
5IRAK32.78769558
6TLK12.70208355
7NUAK12.55929164
8MAP3K142.53356145
9IRAK42.32926270
10TXK2.26648455
11ADRBK21.80323201
12GRK11.77225320
13EIF2AK21.76638979
14AKT31.71035861
15TIE11.70465814
16PRPF4B1.66454344
17BLK1.62597179
18BCKDK1.56573982
19YES11.53920800
20TNIK1.53619866
21GRK71.51036990
22BMPR1B1.49863345
23TAOK31.48508924
24PINK11.39606766
25BMPR21.38351907
26MKNK21.34829355
27IRAK11.32570449
28IRAK21.30633982
29SRPK11.29599909
30MUSK1.23977612
31CDK31.19498190
32VRK11.18928375
33NME21.16612999
34LATS11.10538457
35MAP2K71.06212051
36TNK21.05650503
37PKN11.04399373
38MST1R1.03414638
39ERBB40.98478439
40MAPK150.98433532
41IKBKB0.94910188
42NLK0.94112239
43TEC0.92818643
44FGFR40.89243231
45PBK0.89164412
46IKBKE0.86746802
47EPHB20.80738794
48PIK3CG0.78949555
49CLK10.78897979
50NEK60.78762316
51STK38L0.78035930
52MAPK130.72272951
53SGK20.71841244
54MKNK10.71044087
55DYRK20.70392714
56PLK40.67989109
57PRKCE0.66781092
58TYK20.65520553
59CHUK0.63132636
60CSNK1A1L0.61639001
61CSNK1G10.60545723
62LYN0.60290570
63JAK10.57511817
64EPHA40.54440230
65EPHA30.52656684
66ERBB30.51856690
67MST40.49918445
68TAOK20.49856611
69PRKCQ0.49302404
70PRKG10.46589455
71CAMK2A0.45012983
72RPS6KA50.43249760
73CSNK1G30.42604385
74EIF2AK10.42478233
75MAPK110.42338508
76FRK0.40797962
77ADRBK10.40788303
78DYRK1A0.40429433
79PRKACA0.39930094
80ABL20.39552076
81STK240.36869555
82SYK0.36676411
83PIK3CA0.36479613
84CAMK2G0.36204483
85PRKCG0.35844428
86MAPK40.34752623
87PRKAA20.34092374
88MAPK70.33965603
89MARK10.33863512
90PRKCD0.33499114
91BTK0.33173858
92CSNK1A10.32705660
93SGK4940.32664559
94SGK2230.32664559
95SIK30.32348782
96PRKCA0.31274684
97MAP2K60.31250506
98ABL10.30874198
99CAMK2B0.29715907
100CSNK2A10.29588076

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.68399291
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.68148218
3Complement and coagulation cascades_Homo sapiens_hsa046102.55934178
4Steroid hormone biosynthesis_Homo sapiens_hsa001402.49171294
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.47771543
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.45109757
7Tryptophan metabolism_Homo sapiens_hsa003802.39787150
8Retinol metabolism_Homo sapiens_hsa008302.38344334
9Histidine metabolism_Homo sapiens_hsa003402.35159611
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.19481529
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.16982549
12Peroxisome_Homo sapiens_hsa041462.16933246
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13758296
14Chemical carcinogenesis_Homo sapiens_hsa052042.13044277
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.12016364
16Staphylococcus aureus infection_Homo sapiens_hsa051501.99799405
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.95551656
18Arginine biosynthesis_Homo sapiens_hsa002201.94414721
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.93508891
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.88938017
21Fatty acid elongation_Homo sapiens_hsa000621.87839767
22beta-Alanine metabolism_Homo sapiens_hsa004101.86800423
23ABC transporters_Homo sapiens_hsa020101.76983371
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75823305
25Caffeine metabolism_Homo sapiens_hsa002321.73678662
26Steroid biosynthesis_Homo sapiens_hsa001001.67262751
27Tyrosine metabolism_Homo sapiens_hsa003501.63158300
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59234675
29Fatty acid degradation_Homo sapiens_hsa000711.56203697
30Sulfur metabolism_Homo sapiens_hsa009201.55812856
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.55414310
32Phenylalanine metabolism_Homo sapiens_hsa003601.54825211
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47612746
34Butanoate metabolism_Homo sapiens_hsa006501.43389927
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42927435
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42419330
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39172469
38Vitamin digestion and absorption_Homo sapiens_hsa049771.36777271
39Nitrogen metabolism_Homo sapiens_hsa009101.31426468
40Graft-versus-host disease_Homo sapiens_hsa053321.22533932
41Autoimmune thyroid disease_Homo sapiens_hsa053201.18353213
42PPAR signaling pathway_Homo sapiens_hsa033201.17558236
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16151432
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.13345772
45Linoleic acid metabolism_Homo sapiens_hsa005911.10646310
46Ribosome_Homo sapiens_hsa030101.09966066
47Propanoate metabolism_Homo sapiens_hsa006401.09100454
48Starch and sucrose metabolism_Homo sapiens_hsa005001.07520880
49Selenocompound metabolism_Homo sapiens_hsa004501.04196433
50Arginine and proline metabolism_Homo sapiens_hsa003301.02254586
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00172906
52Arachidonic acid metabolism_Homo sapiens_hsa005900.98350707
53Fanconi anemia pathway_Homo sapiens_hsa034600.97934775
54Allograft rejection_Homo sapiens_hsa053300.94376302
55Fatty acid metabolism_Homo sapiens_hsa012120.90724190
56One carbon pool by folate_Homo sapiens_hsa006700.90405393
57Vitamin B6 metabolism_Homo sapiens_hsa007500.87552800
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.86569330
59* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86497233
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78447276
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75984340
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74756834
63Bile secretion_Homo sapiens_hsa049760.71040892
64Oxidative phosphorylation_Homo sapiens_hsa001900.67318343
65Metabolic pathways_Homo sapiens_hsa011000.66832309
66Folate biosynthesis_Homo sapiens_hsa007900.66273895
67Homologous recombination_Homo sapiens_hsa034400.65854325
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64713271
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63755445
70Fat digestion and absorption_Homo sapiens_hsa049750.62508581
71Protein export_Homo sapiens_hsa030600.62291485
72Phototransduction_Homo sapiens_hsa047440.61865508
73Nicotine addiction_Homo sapiens_hsa050330.61571355
74Primary immunodeficiency_Homo sapiens_hsa053400.59345373
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.53598252
76Pyrimidine metabolism_Homo sapiens_hsa002400.52844230
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.52380722
78Ether lipid metabolism_Homo sapiens_hsa005650.51103407
79Glutathione metabolism_Homo sapiens_hsa004800.49887165
80Asthma_Homo sapiens_hsa053100.46981968
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44400965
82Sphingolipid metabolism_Homo sapiens_hsa006000.39890380
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39486449
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36190231
85Lysine degradation_Homo sapiens_hsa003100.35965641
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35716219
87Non-homologous end-joining_Homo sapiens_hsa034500.35489158
88Regulation of autophagy_Homo sapiens_hsa041400.30991178
89Sulfur relay system_Homo sapiens_hsa041220.30979018
90Hematopoietic cell lineage_Homo sapiens_hsa046400.30810963
91African trypanosomiasis_Homo sapiens_hsa051430.29125162
92Alzheimers disease_Homo sapiens_hsa050100.28923573
93Rheumatoid arthritis_Homo sapiens_hsa053230.27998705
94Systemic lupus erythematosus_Homo sapiens_hsa053220.27422003
95RNA polymerase_Homo sapiens_hsa030200.26338702
96Ovarian steroidogenesis_Homo sapiens_hsa049130.25252486
97* Taste transduction_Homo sapiens_hsa047420.22114498
98Malaria_Homo sapiens_hsa051440.22050147
99Measles_Homo sapiens_hsa051620.20259867
100Purine metabolism_Homo sapiens_hsa002300.20125912

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »