P2RY6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)8.06033884
2modulation by symbiont of host defense response (GO:0052031)8.06033884
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:008.06033884
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:08.06033884
5positive regulation by organism of defense response of other organism involved in symbiotic interact8.06033884
6modulation by symbiont of host immune response (GO:0052553)8.06033884
7regulation of interferon-beta biosynthetic process (GO:0045357)6.70630268
8microglial cell activation (GO:0001774)6.47130070
9macrophage activation involved in immune response (GO:0002281)6.12516685
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.33008043
11response to host immune response (GO:0052572)5.14897851
12response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.14897851
13positive regulation of interferon-alpha production (GO:0032727)5.14659190
14positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.11862773
15neutrophil activation involved in immune response (GO:0002283)5.08191665
16negative regulation of interleukin-12 production (GO:0032695)5.05482287
17immunoglobulin mediated immune response (GO:0016064)4.90209151
18regulation of interferon-alpha production (GO:0032647)4.89123405
19response to host (GO:0075136)4.74937606
20response to host defenses (GO:0052200)4.74937606
21response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.74937606
22response to peptidoglycan (GO:0032494)4.72982597
23macrophage activation (GO:0042116)4.70709692
24regulation of vitamin D biosynthetic process (GO:0060556)4.48594697
25regulation of cytokine secretion involved in immune response (GO:0002739)4.31608564
26regulation of B cell receptor signaling pathway (GO:0050855)4.30540393
27positive regulation of antigen processing and presentation (GO:0002579)4.11317642
28pinocytosis (GO:0006907)4.10944283
29myeloid cell activation involved in immune response (GO:0002275)4.09494854
30respiratory burst (GO:0045730)4.06355152
31regulation of mononuclear cell migration (GO:0071675)3.93642262
32oligosaccharide catabolic process (GO:0009313)3.93598547
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.75590921
34NIK/NF-kappaB signaling (GO:0038061)3.74553282
35regulation of podosome assembly (GO:0071801)3.71162566
36amino sugar catabolic process (GO:0046348)3.69573502
37I-kappaB phosphorylation (GO:0007252)3.65491413
38positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.64666183
39regulation of interleukin-8 biosynthetic process (GO:0045414)3.64405004
40negative regulation of granulocyte differentiation (GO:0030853)3.64053067
41positive regulation of interferon-beta production (GO:0032728)3.61097290
42monocyte chemotaxis (GO:0002548)3.59867133
43positive regulation of mast cell activation (GO:0033005)3.56964709
44regulation of vitamin metabolic process (GO:0030656)3.54777935
45regulation of chemokine biosynthetic process (GO:0045073)3.52404118
46cellular extravasation (GO:0045123)3.51030709
47eosinophil chemotaxis (GO:0048245)3.50808325
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.49535621
49response to protozoan (GO:0001562)3.49447733
50lipopolysaccharide-mediated signaling pathway (GO:0031663)3.46942886
51regulation of antigen processing and presentation (GO:0002577)3.45948468
52negative regulation of cytokine production involved in immune response (GO:0002719)3.45317426
53ceramide catabolic process (GO:0046514)3.44698842
54granulocyte activation (GO:0036230)3.44611914
55negative regulation of myeloid cell apoptotic process (GO:0033033)3.44328218
56regulation of mast cell degranulation (GO:0043304)3.44066963
57neutrophil activation (GO:0042119)3.41857645
58positive regulation of heat generation (GO:0031652)3.41782129
59type I interferon signaling pathway (GO:0060337)3.40378643
60cellular response to type I interferon (GO:0071357)3.40378643
61membrane lipid catabolic process (GO:0046466)3.39643301
62B cell mediated immunity (GO:0019724)3.39063622
63branching involved in labyrinthine layer morphogenesis (GO:0060670)3.38907242
64response to type I interferon (GO:0034340)3.37019659
65negative regulation of nitric oxide biosynthetic process (GO:0045019)3.35812980
66positive regulation of cellular amide metabolic process (GO:0034250)3.34856777
67production of molecular mediator involved in inflammatory response (GO:0002532)3.33879600
68positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.30561462
69regulation of mast cell activation involved in immune response (GO:0033006)3.29817146
70hyaluronan catabolic process (GO:0030214)3.29143270
71interferon-gamma secretion (GO:0072643)3.28060350
72N-acetylneuraminate metabolic process (GO:0006054)3.27887751
73regulation of macrophage chemotaxis (GO:0010758)3.27385443
74regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24775287
75positive regulation of monocyte chemotaxis (GO:0090026)3.24278128
76positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.23468555
77regulation of mast cell activation (GO:0033003)3.22597093
78positive regulation of leukocyte degranulation (GO:0043302)3.22011212
79positive regulation of mast cell activation involved in immune response (GO:0033008)3.21963291
80positive regulation of mast cell degranulation (GO:0043306)3.21963291
81sphingolipid catabolic process (GO:0030149)3.21170883
82response to thyroid hormone (GO:0097066)3.20407164
83virion attachment to host cell (GO:0019062)3.20236977
84adhesion of symbiont to host cell (GO:0044650)3.20236977
85regulation of T-helper 1 cell differentiation (GO:0045625)3.18471785
86myeloid dendritic cell activation (GO:0001773)3.16029053
87regulation of fever generation (GO:0031620)3.15826801
88positive regulation of type 2 immune response (GO:0002830)3.15645438
89regulation of leukocyte degranulation (GO:0043300)3.15108811
90myeloid leukocyte activation (GO:0002274)3.14891202
91negative regulation of mast cell activation (GO:0033004)3.13733334
92defense response to protozoan (GO:0042832)3.12421192
93lymphocyte chemotaxis (GO:0048247)3.11646513
94glycosphingolipid catabolic process (GO:0046479)3.08922239
95regulation of chronic inflammatory response (GO:0002676)3.08327392
96eosinophil migration (GO:0072677)3.08249644
97response to muramyl dipeptide (GO:0032495)3.05772493
98cellular response to lipopolysaccharide (GO:0071222)3.05570346
99negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.02279879
100regulation of membrane protein ectodomain proteolysis (GO:0051043)3.00277429
101positive regulation of macrophage cytokine production (GO:0060907)2.97366750
102germinal center formation (GO:0002467)2.97317177
103positive regulation of chemokine biosynthetic process (GO:0045080)2.95956386
104cellular response to interferon-gamma (GO:0071346)2.95926322
105cellular response to molecule of bacterial origin (GO:0071219)2.95594168
106detection of molecule of bacterial origin (GO:0032490)2.95512689
107phagocytosis, engulfment (GO:0006911)2.93695628
108regulation of cholesterol storage (GO:0010885)2.93654112
109negative regulation of interleukin-17 production (GO:0032700)2.93574724
110positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.93525721
111negative regulation of interleukin-6 production (GO:0032715)2.91351134
112positive regulation of B cell differentiation (GO:0045579)2.89251854
113interferon-gamma-mediated signaling pathway (GO:0060333)2.88608533
114regulation of interferon-gamma biosynthetic process (GO:0045072)2.87156788
115response to interferon-gamma (GO:0034341)2.86891404
116regulation of monocyte chemotaxis (GO:0090025)2.86571778
117positive regulation of toll-like receptor signaling pathway (GO:0034123)2.85911136
118regulation of myeloid leukocyte mediated immunity (GO:0002886)2.85426398
119regulation of inflammatory response to antigenic stimulus (GO:0002861)2.84671018
120amyloid precursor protein catabolic process (GO:0042987)2.83735365
121positive regulation of chemokine production (GO:0032722)2.81797748
122adhesion of symbiont to host (GO:0044406)2.81414939
123negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.80548981
124regulation of immunoglobulin secretion (GO:0051023)2.79651470
125negative regulation of production of molecular mediator of immune response (GO:0002701)2.77781709
126positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.75226614
127positive regulation of gamma-delta T cell activation (GO:0046645)2.74951358
128glycolipid catabolic process (GO:0019377)2.74798473
129mast cell activation (GO:0045576)2.74776301
130regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.74402675
131sphingosine metabolic process (GO:0006670)2.72774724
132cellular response to thyroid hormone stimulus (GO:0097067)2.72642484
133barbed-end actin filament capping (GO:0051016)2.71518525
134decidualization (GO:0046697)2.71327810
135regulation of T-helper 2 cell differentiation (GO:0045628)2.71145168
136positive regulation of interleukin-6 production (GO:0032755)2.70152767
137regulation of interferon-beta production (GO:0032648)2.69735247
138regulation of interleukin-12 production (GO:0032655)2.69472074
139adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.69103298
140phagosome maturation (GO:0090382)2.68702639
141positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.68314931
142myeloid dendritic cell differentiation (GO:0043011)2.68290477
143regulation of macrophage cytokine production (GO:0010935)2.68055758
144positive regulation of chemokine secretion (GO:0090197)2.66393739
145apoptotic cell clearance (GO:0043277)2.66299456
146neutrophil chemotaxis (GO:0030593)2.64916470
147hydrogen peroxide biosynthetic process (GO:0050665)2.63860422
148keratan sulfate catabolic process (GO:0042340)2.63102693
149positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.61354565
150positive regulation of tumor necrosis factor production (GO:0032760)2.61168698
151antigen processing and presentation of endogenous antigen (GO:0019883)2.59875884
152* G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.59401867
153dendritic cell differentiation (GO:0097028)2.59237078
154lymphocyte mediated immunity (GO:0002449)2.58060941
155positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.57877073
156T-helper 1 type immune response (GO:0042088)2.57789696
157neutrophil migration (GO:1990266)2.57169118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.80786144
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.78423012
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.72902653
4IRF8_27001747_Chip-Seq_BMDM_Mouse5.02882845
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.71863422
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.93648865
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.71502378
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20982605
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.99262047
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.98400927
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.82509378
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68076164
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60097179
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55633960
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.49114469
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46341446
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45192250
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37684656
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.31694067
20* SPI1_23127762_ChIP-Seq_K562_Human2.21972517
21* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14573416
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.10717245
23* SPI1_23547873_ChIP-Seq_NB4_Human2.07597590
24* ESR2_21235772_ChIP-Seq_MCF-7_Human1.98940662
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91560704
26VDR_24763502_ChIP-Seq_THP-1_Human1.90715272
27GATA1_22025678_ChIP-Seq_K562_Human1.89344413
28VDR_24787735_ChIP-Seq_THP-1_Human1.87989987
29SCL_19346495_ChIP-Seq_HPC-7_Human1.84764470
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83213530
31PU_27001747_Chip-Seq_BMDM_Mouse1.82994220
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82488287
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78162785
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.76797208
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74593730
36RUNX_20019798_ChIP-Seq_JUKART_Human1.70763288
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69912052
38CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69297885
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59285668
40NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.53390144
41VDR_21846776_ChIP-Seq_THP-1_Human1.52518270
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50379372
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.49294382
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45848931
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43037359
46MAF_26560356_Chip-Seq_TH1_Human1.42250138
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39391972
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38366458
49ZNF263_19887448_ChIP-Seq_K562_Human1.38183717
50MYB_26560356_Chip-Seq_TH2_Human1.37795566
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36865582
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35356698
53CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33664027
54CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30843055
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30006858
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28393124
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28330083
58STAT1_20625510_ChIP-Seq_HELA_Human1.27656263
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27316567
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25582697
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22027650
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21589808
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21514249
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19767280
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.17010790
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16770245
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15509140
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15366750
69RACK7_27058665_Chip-Seq_MCF-7_Human1.13716426
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12443043
71* TCF7_22412390_ChIP-Seq_EML_Mouse1.11314599
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11284436
73BCOR_27268052_Chip-Seq_Bcells_Human1.11183415
74BCL6_27268052_Chip-Seq_Bcells_Human1.09772334
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.09319101
76MYB_26560356_Chip-Seq_TH1_Human1.09002335
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08915316
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07823598
79RXR_22158963_ChIP-Seq_LIVER_Mouse1.07220781
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06400612
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05724798
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05179895
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05152795
84GATA3_26560356_Chip-Seq_TH2_Human1.04533463
85GATA1_19941826_ChIP-Seq_K562_Human1.03893567
86PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03778834
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00898424
88UTX_26944678_Chip-Seq_JUKART_Human1.00156929
89GATA3_27048872_Chip-Seq_THYMUS_Human1.00010802
90GATA2_19941826_ChIP-Seq_K562_Human0.99968807
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98851312
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.98779800
93GATA1_19941827_ChIP-Seq_MEL_Mouse0.98243026
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92774099
95RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91440865
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91202538
97ELF5_23300383_ChIP-Seq_T47D_Human0.89694545
98CTCF_26484167_Chip-Seq_Bcells_Mouse0.88044185
99EGR1_19032775_ChIP-ChIP_M12_Human0.88020415
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87834247
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87512547
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87159067
103SOX2_20726797_ChIP-Seq_SW620_Human0.86364159
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86144197
105KDM2B_26808549_Chip-Seq_DND41_Human0.85782475
106LXR_22158963_ChIP-Seq_LIVER_Mouse0.85372771
107* LXR_22292898_ChIP-Seq_THP-1_Human0.84990123
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84582993
109MAF_26560356_Chip-Seq_TH2_Human0.83256253
110* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82481138
111SPI1_20517297_ChIP-Seq_HL60_Human0.82238935
112TFEB_21752829_ChIP-Seq_HELA_Human0.82083316
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78655766
114IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78563702
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76469336
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76013238
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75610119
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.74515162
119CJUN_26792858_Chip-Seq_BT549_Human0.74453710
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74182442
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74182442
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74172988
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.74143305
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.73973293
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72776861
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72682463
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72233193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.33832373
2MP0001835_abnormal_antigen_presentation4.31495028
3MP0006082_CNS_inflammation3.66835201
4MP0003436_decreased_susceptibility_to3.62696954
5MP0003303_peritoneal_inflammation3.41819134
6MP0003172_abnormal_lysosome_physiology3.34741442
7MP0002419_abnormal_innate_immunity3.11346704
8MP0002148_abnormal_hypersensitivity_rea3.07469014
9MP0003191_abnormal_cellular_cholesterol2.99549551
10MP0009840_abnormal_foam_cell2.88518910
11MP0003806_abnormal_nucleotide_metabolis2.87784481
12MP0005000_abnormal_immune_tolerance2.77976381
13MP0002139_abnormal_hepatobiliary_system2.53445817
14MP0009785_altered_susceptibility_to2.50150874
15MP0003690_abnormal_glial_cell2.39670738
16MP0005671_abnormal_response_to2.38436753
17MP0004510_myositis2.36369270
18MP0005025_abnormal_response_to2.36053776
19MP0002452_abnormal_antigen_presenting2.35106112
20MP0001790_abnormal_immune_system2.33939447
21MP0005387_immune_system_phenotype2.33939447
22MP0005464_abnormal_platelet_physiology2.30445604
23MP0001533_abnormal_skeleton_physiology2.21227444
24MP0003300_gastrointestinal_ulcer2.15889143
25MP0001800_abnormal_humoral_immune2.12079720
26MP0002723_abnormal_immune_serum2.11284521
27MP0002254_reproductive_system_inflammat2.08252084
28MP0005451_abnormal_body_composition2.06260677
29MP0003724_increased_susceptibility_to2.01114921
30MP0000343_altered_response_to1.97097524
31MP0000604_amyloidosis1.93896005
32MP0003075_altered_response_to1.93406424
33MP0001819_abnormal_immune_cell1.86569622
34MP0000685_abnormal_immune_system1.86560507
35MP0002420_abnormal_adaptive_immunity1.84236236
36MP0006054_spinal_hemorrhage1.83657949
37MP0003183_abnormal_peptide_metabolism1.83311343
38MP0002405_respiratory_system_inflammati1.79294384
39MP0005310_abnormal_salivary_gland1.79143589
40MP0001845_abnormal_inflammatory_respons1.69110837
41MP0005257_abnormal_intraocular_pressure1.64069107
42MP0008469_abnormal_protein_level1.58319595
43MP0008004_abnormal_stomach_pH1.55681516
44MP0002998_abnormal_bone_remodeling1.54303697
45MP0003453_abnormal_keratinocyte_physiol1.53216458
46MP0001853_heart_inflammation1.48593058
47MP0003828_pulmonary_edema1.43093052
48MP0005166_decreased_susceptibility_to1.42950864
49MP0004947_skin_inflammation1.40699286
50MP0009333_abnormal_splenocyte_physiolog1.39100071
51MP0003448_altered_tumor_morphology1.38705076
52MP0009764_decreased_sensitivity_to1.35998283
53MP0009278_abnormal_bone_marrow1.32940469
54MP0010155_abnormal_intestine_physiology1.31557635
55MP0001851_eye_inflammation1.29426502
56MP0005167_abnormal_blood-brain_barrier1.27713740
57MP0008438_abnormal_cutaneous_collagen1.26740547
58MP0000716_abnormal_immune_system1.26261789
59MP0010307_abnormal_tumor_latency1.23831887
60MP0002138_abnormal_hepatobiliary_system1.21426348
61MP0000465_gastrointestinal_hemorrhage1.17387690
62MP0003566_abnormal_cell_adhesion1.15660429
63MP0000689_abnormal_spleen_morphology1.15376544
64MP0000569_abnormal_digit_pigmentation1.11875714
65MP0002277_abnormal_respiratory_mucosa1.09129262
66MP0005390_skeleton_phenotype1.08060265
67MP0002398_abnormal_bone_marrow1.06296833
68MP0004883_abnormal_blood_vessel1.02095608
69MP0000858_altered_metastatic_potential1.01296899
70MP0002933_joint_inflammation1.01166107
71MP0002429_abnormal_blood_cell1.00919491
72MP0005164_abnormal_response_to0.98179678
73MP0002166_altered_tumor_susceptibility0.97844148
74MP0002090_abnormal_vision0.97541434
75MP0002332_abnormal_exercise_endurance0.96665654
76MP0003186_abnormal_redox_activity0.94851054
77MP0002722_abnormal_immune_system0.93998604
78MP0000249_abnormal_blood_vessel0.91925369
79MP0008260_abnormal_autophagy0.89807603
80MP0005365_abnormal_bile_salt0.89427741
81MP0003795_abnormal_bone_structure0.86011753
82MP0001545_abnormal_hematopoietic_system0.84236263
83MP0005397_hematopoietic_system_phenotyp0.84236263
84MP0005076_abnormal_cell_differentiation0.83910561
85MP0003045_fibrosis0.83181575
86MP0003279_aneurysm0.82967184
87MP0009763_increased_sensitivity_to0.81515768
88MP0004782_abnormal_surfactant_physiolog0.79032413
89MP0002006_tumorigenesis0.78968179
90MP0005647_abnormal_sex_gland0.77871514
91MP0005319_abnormal_enzyme/_coenzyme0.76283877
92MP0000767_abnormal_smooth_muscle0.74593970
93MP0001663_abnormal_digestive_system0.74046465
94MP0004233_abnormal_muscle_weight0.73390329
95MP0003195_calcinosis0.72496858
96MP0000920_abnormal_myelination0.72054298
97MP0005584_abnormal_enzyme/coenzyme_acti0.71795550
98MP0000609_abnormal_liver_physiology0.71222230
99MP0001542_abnormal_bone_strength0.70791919
100MP0002136_abnormal_kidney_physiology0.70564147
101MP0008874_decreased_physiological_sensi0.70266778
102MP0002837_dystrophic_cardiac_calcinosis0.68692897
103MP0001915_intracranial_hemorrhage0.68615102
104MP0009765_abnormal_xenobiotic_induced0.68384253
105MP0000015_abnormal_ear_pigmentation0.68309624
106MP0004019_abnormal_vitamin_homeostasis0.67251597
107MP0005174_abnormal_tail_pigmentation0.67186667
108MP0010386_abnormal_urinary_bladder0.66466907
109MP0005197_abnormal_uvea_morphology0.66130782
110MP0003656_abnormal_erythrocyte_physiolo0.66094163
111MP0005165_increased_susceptibility_to0.64851643
112MP0001764_abnormal_homeostasis0.64195645
113MP0003634_abnormal_glial_cell0.63620256
114MP0005670_abnormal_white_adipose0.63277114
115MP0002693_abnormal_pancreas_physiology0.61950416
116MP0003705_abnormal_hypodermis_morpholog0.61449842
117MP0001873_stomach_inflammation0.61109911
118MP0008875_abnormal_xenobiotic_pharmacok0.59274436
119MP0000371_diluted_coat_color0.58358310
120MP0009643_abnormal_urine_homeostasis0.58216159
121MP0000490_abnormal_crypts_of0.58053582
122MP0005023_abnormal_wound_healing0.57558675
123MP0002135_abnormal_kidney_morphology0.56815109
124MP0002295_abnormal_pulmonary_circulatio0.55649146
125MP0008873_increased_physiological_sensi0.55617892
126MP0004264_abnormal_extraembryonic_tissu0.55321994
127MP0003879_abnormal_hair_cell0.54504492

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.92693920
2Increased cerebral lipofuscin (HP:0011813)6.62109973
3Recurrent abscess formation (HP:0002722)6.52346396
4Glomerulonephritis (HP:0000099)6.11662038
5Increased neuronal autofluorescent lipopigment (HP:0002074)6.01035258
6Vacuolated lymphocytes (HP:0001922)5.90931434
7Recurrent bacterial skin infections (HP:0005406)5.86543207
8Dysostosis multiplex (HP:0000943)5.48619834
9Abnormality of liposaccharide metabolism (HP:0010968)5.45229219
10Abnormality of glycosphingolipid metabolism (HP:0004343)5.45229219
11Abnormality of glycolipid metabolism (HP:0010969)5.45229219
12Eczematoid dermatitis (HP:0000976)5.17558345
13Recurrent gram-negative bacterial infections (HP:0005420)4.47437849
14Complement deficiency (HP:0004431)4.46128012
15Mucopolysacchariduria (HP:0008155)4.26885963
16Urinary glycosaminoglycan excretion (HP:0003541)4.26885963
17Axonal loss (HP:0003447)4.19713424
18Abnormality of complement system (HP:0005339)4.19400570
19Disinhibition (HP:0000734)4.11211256
20Abnormality of macrophages (HP:0004311)4.05289333
21Abnormality of mucopolysaccharide metabolism (HP:0011020)4.03708320
22Abnormality of polysaccharide metabolism (HP:0011012)4.03708320
23Abnormality of glycosaminoglycan metabolism (HP:0004371)4.03708320
24Nuclear cataract (HP:0100018)3.55499268
25Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.53992182
26Nephritis (HP:0000123)3.46324298
27Agnosia (HP:0010524)3.44058663
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.37268622
29Recurrent skin infections (HP:0001581)3.24399551
30Gingivitis (HP:0000230)3.20911181
31Increased serum ferritin (HP:0003281)3.10757799
32Myositis (HP:0100614)3.06676374
33Mediastinal lymphadenopathy (HP:0100721)3.01961937
34Thick nail (HP:0001805)2.96160179
35Loss of speech (HP:0002371)2.92138649
36Elevated erythrocyte sedimentation rate (HP:0003565)2.90873664
37Hematochezia (HP:0002573)2.84966306
38Obstructive lung disease (HP:0006536)2.84239895
39Chronic obstructive pulmonary disease (HP:0006510)2.84239895
40Orchitis (HP:0100796)2.83256884
41Upper motor neuron abnormality (HP:0002127)2.78593790
42Prostate neoplasm (HP:0100787)2.76655666
43Myocardial infarction (HP:0001658)2.71354619
44Hepatosplenomegaly (HP:0001433)2.69583828
45Basal ganglia calcification (HP:0002135)2.67995161
46Autoimmune thrombocytopenia (HP:0001973)2.67856936
47Pustule (HP:0200039)2.63300043
48Pathologic fracture (HP:0002756)2.62506882
49Retinal atrophy (HP:0001105)2.61692194
50J-shaped sella turcica (HP:0002680)2.59801078
51Metaphyseal irregularity (HP:0003025)2.55510105
52Prolonged neonatal jaundice (HP:0006579)2.51854028
53Periodontitis (HP:0000704)2.50351910
54Abnormality of iron homeostasis (HP:0011031)2.46069355
55Progressive visual loss (HP:0000529)2.45737945
56Purpura (HP:0000979)2.45122661
57Asymmetric septal hypertrophy (HP:0001670)2.44919347
58Stomatitis (HP:0010280)2.43874450
59Recurrent fungal infections (HP:0002841)2.40357447
60Malnutrition (HP:0004395)2.38282837
61Mutism (HP:0002300)2.36951820
62Spontaneous hematomas (HP:0007420)2.36516094
63Abnormality of the vasculature of the conjunctiva (HP:0008054)2.36054053
64Osteolytic defects of the phalanges of the hand (HP:0009771)2.31568768
65Osteolytic defects of the hand bones (HP:0009699)2.31568768
66Apathy (HP:0000741)2.29563014
67Progressive neurologic deterioration (HP:0002344)2.28087727
68Cellulitis (HP:0100658)2.27493880
69Diminished motivation (HP:0000745)2.25166987
70Peripheral demyelination (HP:0011096)2.24177305
71Dementia (HP:0000726)2.23063189
72Polyneuropathy (HP:0001271)2.22103211
73Retrobulbar optic neuritis (HP:0100654)2.21068468
74Optic neuritis (HP:0100653)2.21068468
75Personality changes (HP:0000751)2.20197083
76Neuronal loss in central nervous system (HP:0002529)2.20086455
77Interstitial pulmonary disease (HP:0006530)2.19271990
78Thoracic kyphosis (HP:0002942)2.18092015
79Petechiae (HP:0000967)2.17273694
80Bone pain (HP:0002653)2.13827374
81Cardiomegaly (HP:0001640)2.13746039
82Recurrent viral infections (HP:0004429)2.12156948
83Conjunctival telangiectasia (HP:0000524)2.11534518
84Abnormality of the lumbar spine (HP:0100712)2.10859330
85Abnormality of transition element cation homeostasis (HP:0011030)2.10567064
86Colitis (HP:0002583)2.10264155
87Cerebral inclusion bodies (HP:0100314)2.10131448
88Urticaria (HP:0001025)2.09198562
89Arterial tortuosity (HP:0005116)2.08985904
90Vasculitis (HP:0002633)2.08638437
91Osteomyelitis (HP:0002754)2.06412401
92Nausea (HP:0002018)2.04633320
93Neurofibrillary tangles (HP:0002185)2.03692020
94Hemoptysis (HP:0002105)2.03051384
95Inappropriate behavior (HP:0000719)2.02530377
96Urethral obstruction (HP:0000796)2.02443562
97Pulmonary infiltrates (HP:0002113)2.02385511
98Abnormal platelet function (HP:0011869)2.01453969
99Impaired platelet aggregation (HP:0003540)2.01453969
100Cerebral aneurysm (HP:0004944)1.99698324
101Recurrent pneumonia (HP:0006532)1.90137487
102Increased CSF protein (HP:0002922)1.89698871
103Spondylolisthesis (HP:0003302)1.85318499
104Increased IgM level (HP:0003496)1.84207927
105Inflammation of the large intestine (HP:0002037)1.83202833
106Memory impairment (HP:0002354)1.82941719
107Vascular tortuosity (HP:0004948)1.81911342
108Amyloidosis (HP:0011034)1.81522307
109Abnormality of the basal ganglia (HP:0002134)1.80563665
110Joint hemorrhage (HP:0005261)1.80142790
111Abnormality of the periventricular white matter (HP:0002518)1.80046341
112Abnormality of lateral ventricle (HP:0030047)1.79442155
113Vertebral compression fractures (HP:0002953)1.79380574
114Global brain atrophy (HP:0002283)1.79380264
115Deformed sella turcica (HP:0002681)1.78268396
116Multiple enchondromatosis (HP:0005701)1.77858654
117Keratoconjunctivitis sicca (HP:0001097)1.75277704
118Leukocytosis (HP:0001974)1.73947952
119Mucosal telangiectasiae (HP:0100579)1.73383510
120Arterial thrombosis (HP:0004420)1.71536152
121Gastrointestinal inflammation (HP:0004386)1.69325150
122Thin bony cortex (HP:0002753)1.65875062
123Supranuclear gaze palsy (HP:0000605)1.65392076
124Keratoconjunctivitis (HP:0001096)1.61303326
125Flat occiput (HP:0005469)1.59507867
126Esophageal varix (HP:0002040)1.57231089
127Bone cyst (HP:0012062)1.56447013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.49959184
2BLK4.05556294
3ERN13.59891604
4TYK23.12984448
5RIPK43.03325874
6IRAK42.95057018
7TBK12.85671433
8GRK72.73571113
9IRAK32.72892486
10DDR22.71727811
11MAP3K142.64034411
12KIT2.57212103
13MAP4K12.39779503
14CSF1R2.27159040
15NEK92.22159302
16TAOK22.11907188
17TAOK32.00228607
18JAK11.87894353
19ACVR1B1.87179849
20ZAP701.85339824
21IKBKB1.79528381
22IKBKE1.71260497
23TESK11.69859650
24TXK1.62340746
25TESK21.59310875
26HCK1.59065068
27STK101.58000525
28CSK1.52913402
29SIK31.52434444
30TAOK11.50496667
31EPHB11.47264371
32CAMK1D1.46979056
33JAK21.34707405
34LYN1.34327514
35FES1.30150810
36SYK1.29490637
37BTK1.29351898
38CDC42BPA1.19746576
39MAP2K31.16901017
40MAP2K61.13014939
41CAMKK21.11639478
42MATK1.10867562
43MAPK151.09405606
44PIM21.06697629
45MOS1.05255274
46PAK41.05211167
47JAK31.04703749
48FGR1.04372685
49LCK1.03545043
50CHUK1.02183264
51ITK1.01547755
52MAP3K30.97638942
53MAPKAPK30.95334894
54TRIB30.94403666
55PBK0.93271800
56CAMK1G0.92936702
57SCYL20.91921495
58BMPR20.89678204
59CLK10.83856903
60TEC0.83205995
61MAP3K120.82987031
62CDK60.80980947
63EPHA20.80499146
64PTK60.78747769
65PDK20.78054397
66CAMKK10.77176838
67EGFR0.76424247
68TTN0.75179466
69TGFBR10.71501603
70PRKCD0.71481851
71LATS20.71111443
72MST40.70420519
73LIMK10.70050253
74RPS6KA40.66085759
75YES10.65640726
76PRPF4B0.61896579
77BMX0.61528963
78MAP3K110.59654453
79RIPK10.58104738
80SIK10.57698153
81MAP2K20.56637560
82MST1R0.56632122
83ABL20.56629698
84ABL10.54497291
85NME20.54107884
86BCKDK0.53779149
87PKN20.53397244
88SGK30.53248811
89ADRBK20.52359337
90MAPKAPK20.51538359
91FGFR30.51430280
92MAPK70.50953352
93PIM10.50043901
94ICK0.49912452
95MARK30.49480105
96MAP3K20.48031068
97PIK3CG0.47352283
98FGFR40.45870709
99IGF1R0.45731887
100HIPK20.43888559
101EIF2AK20.43283206
102IRAK20.43269450
103MAP3K130.42781282
104MAP3K10.41940263
105TRPM70.41779646
106PDK10.40920715
107IRAK10.39609877
108FYN0.39602741
109PDGFRB0.39205587
110GSK3A0.38740074
111ARAF0.38282383
112TYRO30.38240617
113MAPK120.36633777
114PDPK10.35185668
115MAP3K50.34631713
116RPS6KA20.34598719
117DMPK0.34349442
118DAPK20.33765597
119TLK10.33673050
120INSRR0.32866110
121DYRK1B0.31984054
122RPS6KA60.31875750
123PRKG20.31193480
124DAPK30.31168771
125OXSR10.31083942
126EPHB20.30500480
127PKN10.30236492
128SIK20.29802881
129EPHA30.29416962
130DAPK10.29390062
131PRKCH0.28516799
132CAMK2G0.28193759
133RPS6KB20.27075213
134GRK50.26491998
135INSR0.26284307
136SRC0.26049238
137RPS6KC10.25117461
138RPS6KL10.25117461
139TNK20.24668258

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.61192919
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.02057202
3Lysosome_Homo sapiens_hsa041423.76269097
4Other glycan degradation_Homo sapiens_hsa005113.45641032
5Leishmaniasis_Homo sapiens_hsa051403.04748429
6Osteoclast differentiation_Homo sapiens_hsa043802.68447143
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.55230088
8Pertussis_Homo sapiens_hsa051332.40114348
9Tuberculosis_Homo sapiens_hsa051522.21210840
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.09440892
11Legionellosis_Homo sapiens_hsa051341.98613514
12Phagosome_Homo sapiens_hsa041451.94696317
13Malaria_Homo sapiens_hsa051441.86506573
14B cell receptor signaling pathway_Homo sapiens_hsa046621.79472803
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.78894552
16Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.74480298
17Rheumatoid arthritis_Homo sapiens_hsa053231.73347395
18Antigen processing and presentation_Homo sapiens_hsa046121.73024452
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70245089
20Toxoplasmosis_Homo sapiens_hsa051451.56563262
21Complement and coagulation cascades_Homo sapiens_hsa046101.50586256
22Salmonella infection_Homo sapiens_hsa051321.49423799
23Measles_Homo sapiens_hsa051621.48978815
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48804794
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45086736
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39647189
27Prion diseases_Homo sapiens_hsa050201.37184271
28Influenza A_Homo sapiens_hsa051641.34681824
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25522506
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25074326
31Apoptosis_Homo sapiens_hsa042101.19616497
32Chemokine signaling pathway_Homo sapiens_hsa040621.17856903
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.13046710
34Asthma_Homo sapiens_hsa053101.11597012
35TNF signaling pathway_Homo sapiens_hsa046681.10680204
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09490419
37Graft-versus-host disease_Homo sapiens_hsa053321.07799672
38Shigellosis_Homo sapiens_hsa051311.06771314
39Hematopoietic cell lineage_Homo sapiens_hsa046401.04784442
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99129749
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95766188
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94815882
43Allograft rejection_Homo sapiens_hsa053300.93533198
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.92768578
45Hepatitis B_Homo sapiens_hsa051610.89957125
46Amoebiasis_Homo sapiens_hsa051460.89722993
47Sulfur metabolism_Homo sapiens_hsa009200.89652882
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89269007
49Chronic myeloid leukemia_Homo sapiens_hsa052200.86726754
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85422323
51African trypanosomiasis_Homo sapiens_hsa051430.84635941
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84528107
53Galactose metabolism_Homo sapiens_hsa000520.84457776
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.84396198
55Pancreatic cancer_Homo sapiens_hsa052120.83933970
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83905012
57Herpes simplex infection_Homo sapiens_hsa051680.83239142
58Bladder cancer_Homo sapiens_hsa052190.81343056
59Platelet activation_Homo sapiens_hsa046110.76695717
60Viral myocarditis_Homo sapiens_hsa054160.76574244
61Endocytosis_Homo sapiens_hsa041440.76419971
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74862704
63Sphingolipid metabolism_Homo sapiens_hsa006000.74553110
64Hepatitis C_Homo sapiens_hsa051600.74149783
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72798222
66Collecting duct acid secretion_Homo sapiens_hsa049660.63923807
67Renin-angiotensin system_Homo sapiens_hsa046140.63055111
68Type II diabetes mellitus_Homo sapiens_hsa049300.62333669
69Caffeine metabolism_Homo sapiens_hsa002320.59570771
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59113493
71Glutathione metabolism_Homo sapiens_hsa004800.58282390
72Proteasome_Homo sapiens_hsa030500.57562572
73Mineral absorption_Homo sapiens_hsa049780.57092366
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.56091402
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55694022
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54374636
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.54054076
78Type I diabetes mellitus_Homo sapiens_hsa049400.53703089
79Tryptophan metabolism_Homo sapiens_hsa003800.53497396
80Acute myeloid leukemia_Homo sapiens_hsa052210.51994594
81T cell receptor signaling pathway_Homo sapiens_hsa046600.51919972
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47760834
83Ether lipid metabolism_Homo sapiens_hsa005650.47134203
84Prolactin signaling pathway_Homo sapiens_hsa049170.45165753
85Notch signaling pathway_Homo sapiens_hsa043300.43778291
86Fructose and mannose metabolism_Homo sapiens_hsa000510.43047044
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40568818
88Vibrio cholerae infection_Homo sapiens_hsa051100.39174225
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38475619
90VEGF signaling pathway_Homo sapiens_hsa043700.36003821
91Renal cell carcinoma_Homo sapiens_hsa052110.35454302
92Synaptic vesicle cycle_Homo sapiens_hsa047210.34767352
93ABC transporters_Homo sapiens_hsa020100.33874596
94Insulin resistance_Homo sapiens_hsa049310.33617947
95HIF-1 signaling pathway_Homo sapiens_hsa040660.33190350
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31801235
97Proteoglycans in cancer_Homo sapiens_hsa052050.31007388
98PPAR signaling pathway_Homo sapiens_hsa033200.29609498
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28599654
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28244256
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.27745939
102Autoimmune thyroid disease_Homo sapiens_hsa053200.26585269
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.25762923
104Arachidonic acid metabolism_Homo sapiens_hsa005900.24286732
105Systemic lupus erythematosus_Homo sapiens_hsa053220.23522837
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23388642
107Adherens junction_Homo sapiens_hsa045200.23026307
108Primary immunodeficiency_Homo sapiens_hsa053400.22769380
109HTLV-I infection_Homo sapiens_hsa051660.22059546
110Viral carcinogenesis_Homo sapiens_hsa052030.21426744
111Focal adhesion_Homo sapiens_hsa045100.20353818
112Starch and sucrose metabolism_Homo sapiens_hsa005000.19548807
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18411298
114Non-small cell lung cancer_Homo sapiens_hsa052230.17579859
115Epstein-Barr virus infection_Homo sapiens_hsa051690.17485362
116Pentose phosphate pathway_Homo sapiens_hsa000300.17332327
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.17258931
118Folate biosynthesis_Homo sapiens_hsa007900.16097873
119Oxidative phosphorylation_Homo sapiens_hsa001900.12930922
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0027823

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