P2RY8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.79373532
2negative regulation of cell killing (GO:0031342)6.10703620
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.10703620
4negative thymic T cell selection (GO:0045060)5.71090813
5negative T cell selection (GO:0043383)5.68522138
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.58330955
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.57551259
8regulation of B cell receptor signaling pathway (GO:0050855)5.56824158
9antigen processing and presentation of endogenous antigen (GO:0019883)5.48308016
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.34702981
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.09588340
12regulation of gamma-delta T cell differentiation (GO:0045586)5.04772054
13regulation of gamma-delta T cell activation (GO:0046643)4.98392894
14positive thymic T cell selection (GO:0045059)4.96103780
15positive regulation of B cell differentiation (GO:0045579)4.77669532
16B cell receptor signaling pathway (GO:0050853)4.64247613
17thymic T cell selection (GO:0045061)4.63938591
18positive T cell selection (GO:0043368)4.61409481
19T cell selection (GO:0045058)4.54191996
20leukocyte aggregation (GO:0070486)4.52152865
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.48172516
22regulation of B cell differentiation (GO:0045577)4.46465414
23T cell migration (GO:0072678)4.45289570
24tolerance induction (GO:0002507)4.39766356
25response to interleukin-15 (GO:0070672)4.28856106
26cellular response to interleukin-15 (GO:0071350)4.07384785
27positive regulation of granulocyte differentiation (GO:0030854)4.02496192
28regulation of alpha-beta T cell proliferation (GO:0046640)4.02444347
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.96142435
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.96142435
31modulation by symbiont of host immune response (GO:0052553)3.96142435
32positive regulation by symbiont of host defense response (GO:0052509)3.96142435
33modulation by symbiont of host defense response (GO:0052031)3.96142435
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.96142435
35negative regulation of T cell mediated immunity (GO:0002710)3.92722098
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.86345769
37positive regulation of alpha-beta T cell proliferation (GO:0046641)3.71262648
38response to muramyl dipeptide (GO:0032495)3.69133672
39detection of bacterium (GO:0016045)3.62519453
40immunoglobulin mediated immune response (GO:0016064)3.60920720
41negative regulation of erythrocyte differentiation (GO:0045647)3.60144888
42mucosal-associated lymphoid tissue development (GO:0048537)3.56205682
43Peyers patch development (GO:0048541)3.56205682
44detection of other organism (GO:0098543)3.55836701
45antigen receptor-mediated signaling pathway (GO:0050851)3.54115444
46negative regulation of leukocyte mediated immunity (GO:0002704)3.51923451
47negative regulation of phagocytosis (GO:0050765)3.46822904
48cellular extravasation (GO:0045123)3.40852546
49activated T cell proliferation (GO:0050798)3.36655398
50neutrophil activation involved in immune response (GO:0002283)3.34835112
51B cell homeostasis (GO:0001782)3.30301289
52regulation of interleukin-2 biosynthetic process (GO:0045076)3.29290124
53regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.24310262
54mast cell activation (GO:0045576)3.23769113
55T cell receptor signaling pathway (GO:0050852)3.23016784
56regulation of T cell tolerance induction (GO:0002664)3.22644592
57NIK/NF-kappaB signaling (GO:0038061)3.22285932
58T cell homeostasis (GO:0043029)3.20836316
59regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.19426270
60regulation of natural killer cell mediated immunity (GO:0002715)3.19426270
61macrophage activation involved in immune response (GO:0002281)3.15496088
62regulation of T cell mediated cytotoxicity (GO:0001914)3.14528110
63antigen processing and presentation via MHC class Ib (GO:0002475)3.14412538
64response to peptidoglycan (GO:0032494)3.13127224
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.13037506
66type I interferon signaling pathway (GO:0060337)3.12881616
67cellular response to type I interferon (GO:0071357)3.12881616
68response to type I interferon (GO:0034340)3.12282905
69regulation of granulocyte differentiation (GO:0030852)3.11377452
70lymphocyte homeostasis (GO:0002260)3.10774783
71positive regulation of interleukin-2 production (GO:0032743)3.05413001
72regulation of tolerance induction (GO:0002643)3.03238934
73negative regulation of innate immune response (GO:0045824)3.02861742
74T cell costimulation (GO:0031295)3.00542474
75myeloid cell activation involved in immune response (GO:0002275)3.00089933
76B cell mediated immunity (GO:0019724)3.00016800
77natural killer cell differentiation (GO:0001779)2.99918945
78interferon-gamma production (GO:0032609)2.99104767
79regulation of alpha-beta T cell activation (GO:0046634)2.97336780
80negative regulation of interleukin-12 production (GO:0032695)2.96649101
81positive regulation of T cell mediated cytotoxicity (GO:0001916)2.96364623
82lymphocyte costimulation (GO:0031294)2.96190151
83positive regulation of isotype switching (GO:0045830)2.95987405
84germinal center formation (GO:0002467)2.94772394
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93497119
86regulation of regulatory T cell differentiation (GO:0045589)2.91898936
87respiratory burst (GO:0045730)2.91006380
88defense response to protozoan (GO:0042832)2.90346269
89positive regulation of B cell activation (GO:0050871)2.88509050
90regulation of isotype switching to IgG isotypes (GO:0048302)2.88193398
91neutrophil activation (GO:0042119)2.87270114
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.85602274
93interferon-gamma-mediated signaling pathway (GO:0060333)2.84711399
94leukocyte degranulation (GO:0043299)2.84414922
95leukocyte homeostasis (GO:0001776)2.82183511
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82028747
97mast cell degranulation (GO:0043303)2.81825700
98mast cell activation involved in immune response (GO:0002279)2.81825700
99positive regulation of alpha-beta T cell activation (GO:0046635)2.79634072
100response to protozoan (GO:0001562)2.79506884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.72968174
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.98953221
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.45799520
4MYC_22102868_ChIP-Seq_BL_Human3.67417668
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.48423249
6RUNX_20019798_ChIP-Seq_JUKART_Human3.39848656
7VDR_21846776_ChIP-Seq_THP-1_Human3.19546770
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.19255871
9MYB_26560356_Chip-Seq_TH2_Human3.15698817
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.11187213
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.00088827
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93385826
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92919475
14MAF_26560356_Chip-Seq_TH1_Human2.82940776
15MYB_26560356_Chip-Seq_TH1_Human2.67655753
16UTX_26944678_Chip-Seq_JUKART_Human2.67197207
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66941695
18SCL_19346495_ChIP-Seq_HPC-7_Human2.66730408
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.66306647
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.64143331
21VDR_24763502_ChIP-Seq_THP-1_Human2.59727953
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.57787448
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.51840495
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50138256
25SPI1_23547873_ChIP-Seq_NB4_Human2.48841168
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.44364116
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41516344
28IRF8_27001747_Chip-Seq_BMDM_Mouse2.29606627
29MAF_26560356_Chip-Seq_TH2_Human2.26476522
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23579231
31MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17822403
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.12952609
33* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12831208
34GATA3_27048872_Chip-Seq_THYMUS_Human2.09864716
35TCF7_22412390_ChIP-Seq_EML_Mouse2.05211557
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97778920
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97335025
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.93814818
39SPI1_23127762_ChIP-Seq_K562_Human1.91954888
40CIITA_25753668_ChIP-Seq_RAJI_Human1.88629303
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85564762
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85508479
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83414612
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76611481
45KDM2B_26808549_Chip-Seq_DND41_Human1.75737299
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70387454
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68586669
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67975810
49GATA3_26560356_Chip-Seq_TH2_Human1.52098039
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51221274
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51118648
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50786095
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49669005
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49482321
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45893939
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42026852
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40301918
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.39284491
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37276515
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.27237957
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.24473279
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23041090
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21796167
64VDR_24787735_ChIP-Seq_THP-1_Human1.21701550
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21674227
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19066496
67PU_27001747_Chip-Seq_BMDM_Mouse1.18147375
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17424484
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.16680359
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12950786
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12941709
72BCL6_27268052_Chip-Seq_Bcells_Human1.11470259
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10913021
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07358618
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.06637756
76LXR_22292898_ChIP-Seq_THP-1_Human1.05706028
77GATA1_19941826_ChIP-Seq_K562_Human1.05061206
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04893445
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03039896
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02407243
81RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01203663
82BCOR_27268052_Chip-Seq_Bcells_Human1.01149527
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00950922
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99215720
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98868248
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94535654
87GATA1_22025678_ChIP-Seq_K562_Human0.94437381
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94227761
89NCOR1_26117541_ChIP-Seq_K562_Human0.93212691
90* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93201017
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93195924
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88129667
93FOXP3_21729870_ChIP-Seq_TREG_Human0.86139871
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85574874
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85121962
96P300_27268052_Chip-Seq_Bcells_Human0.82642124
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81801839
98VDR_23849224_ChIP-Seq_CD4+_Human0.79983682
99SMAD_19615063_ChIP-ChIP_OVARY_Human0.78714569
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76916310

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.23505997
2MP0001835_abnormal_antigen_presentation3.97332927
3MP0005671_abnormal_response_to3.82701827
4MP0003436_decreased_susceptibility_to3.78418494
5MP0001800_abnormal_humoral_immune3.49118689
6MP0000685_abnormal_immune_system3.33228094
7MP0005000_abnormal_immune_tolerance3.19346368
8MP0003724_increased_susceptibility_to3.01330819
9MP0005387_immune_system_phenotype2.98366256
10MP0001790_abnormal_immune_system2.98366256
11MP0002420_abnormal_adaptive_immunity2.84246895
12MP0002723_abnormal_immune_serum2.83896414
13MP0001819_abnormal_immune_cell2.79474595
14MP0002452_abnormal_antigen_presenting2.76173572
15MP0003303_peritoneal_inflammation2.71009701
16MP0005025_abnormal_response_to2.68587454
17MP0002419_abnormal_innate_immunity2.58191595
18MP0002398_abnormal_bone_marrow2.57416725
19MP0002396_abnormal_hematopoietic_system2.47964327
20MP0009333_abnormal_splenocyte_physiolog2.40277785
21MP0000716_abnormal_immune_system2.33760445
22MP0009785_altered_susceptibility_to2.31368525
23MP0003300_gastrointestinal_ulcer2.29121933
24MP0002405_respiratory_system_inflammati2.24884199
25MP0000703_abnormal_thymus_morphology2.24800478
26MP0001873_stomach_inflammation2.21599041
27MP0000689_abnormal_spleen_morphology2.17205394
28MP0006082_CNS_inflammation2.14413340
29MP0002722_abnormal_immune_system2.11646546
30MP0002148_abnormal_hypersensitivity_rea2.10012913
31MP0000465_gastrointestinal_hemorrhage2.05912567
32MP0005464_abnormal_platelet_physiology2.04350239
33MP0010155_abnormal_intestine_physiology1.94797262
34MP0002166_altered_tumor_susceptibility1.90449252
35MP0002429_abnormal_blood_cell1.89447691
36MP0003866_abnormal_defecation1.82076771
37MP0004947_skin_inflammation1.80404833
38MP0009278_abnormal_bone_marrow1.77843398
39MP0001845_abnormal_inflammatory_respons1.70842216
40MP0002009_preneoplasia1.70485411
41MP0001533_abnormal_skeleton_physiology1.58452374
42MP0004381_abnormal_hair_follicle1.53876320
43MP0005310_abnormal_salivary_gland1.46751801
44MP0001851_eye_inflammation1.46678921
45MP0005075_abnormal_melanosome_morpholog1.45133719
46MP0003172_abnormal_lysosome_physiology1.44370241
47MP0008469_abnormal_protein_level1.29020167
48MP0005397_hematopoietic_system_phenotyp1.25584024
49MP0001545_abnormal_hematopoietic_system1.25584024
50MP0002006_tumorigenesis1.22830895
51MP0002132_abnormal_respiratory_system1.22696736
52MP0004808_abnormal_hematopoietic_stem1.20959500
53MP0002933_joint_inflammation1.19841157
54MP0001853_heart_inflammation1.19733601
55MP0000858_altered_metastatic_potential1.16051382
56MP0002138_abnormal_hepatobiliary_system1.14625544
57MP0008260_abnormal_autophagy1.09417471
58MP0000490_abnormal_crypts_of1.00418080
59MP0003191_abnormal_cellular_cholesterol0.99729645
60MP0001986_abnormal_taste_sensitivity0.98773381
61MP0002019_abnormal_tumor_incidence0.98552683
62MP0003828_pulmonary_edema0.98479670
63MP0008057_abnormal_DNA_replication0.94655626
64MP0005451_abnormal_body_composition0.94588671
65MP0009764_decreased_sensitivity_to0.93490374
66MP0002998_abnormal_bone_remodeling0.91617784
67MP0003183_abnormal_peptide_metabolism0.86116246
68MP0001663_abnormal_digestive_system0.85996297
69MP0009763_increased_sensitivity_to0.77516034
70MP0000015_abnormal_ear_pigmentation0.76509666
71MP0004883_abnormal_blood_vessel0.75264487
72MP0004130_abnormal_muscle_cell0.75197655
73MP0002277_abnormal_respiratory_mucosa0.74709812
74MP0001348_abnormal_lacrimal_gland0.70634434
75MP0008961_abnormal_basal_metabolism0.67036923
76MP0003656_abnormal_erythrocyte_physiolo0.65367363
77MP0005058_abnormal_lysosome_morphology0.64576319
78MP0004510_myositis0.63808939
79MP0005166_decreased_susceptibility_to0.61772530
80MP0009765_abnormal_xenobiotic_induced0.61500962
81MP0002693_abnormal_pancreas_physiology0.60745108
82MP0003448_altered_tumor_morphology0.58574695
83MP0000249_abnormal_blood_vessel0.57804931
84MP0005390_skeleton_phenotype0.55278782
85MP0009115_abnormal_fat_cell0.53159619
86MP0003795_abnormal_bone_structure0.49802935
87MP0000604_amyloidosis0.49590996
88MP0003690_abnormal_glial_cell0.49120433
89MP0003075_altered_response_to0.47588917
90MP0003045_fibrosis0.47459786
91MP0000609_abnormal_liver_physiology0.47241551
92MP0005164_abnormal_response_to0.46877145
93MP0008874_decreased_physiological_sensi0.45970885
94MP0002163_abnormal_gland_morphology0.43826945
95MP0003786_premature_aging0.43430403
96MP0005381_digestive/alimentary_phenotyp0.42873214
97MP0000313_abnormal_cell_death0.42074205
98MP0008873_increased_physiological_sensi0.41373649
99MP0002083_premature_death0.39795446
100MP0005334_abnormal_fat_pad0.39626319

Predicted human phenotypes

RankGene SetZ-score
1Abnormal delayed hypersensitivity skin test (HP:0002963)5.35800023
2Eczematoid dermatitis (HP:0000976)5.18730274
3Agammaglobulinemia (HP:0004432)4.79090420
4Elevated erythrocyte sedimentation rate (HP:0003565)4.71291694
5Stomatitis (HP:0010280)4.65491135
6Abnormality of T cell number (HP:0011839)4.59092534
7Panhypogammaglobulinemia (HP:0003139)4.56295824
8Recurrent bacterial skin infections (HP:0005406)4.52607718
9Recurrent abscess formation (HP:0002722)4.52092573
10Recurrent fungal infections (HP:0002841)4.48399250
11Meningitis (HP:0001287)4.48256808
12T lymphocytopenia (HP:0005403)4.35981486
13Myositis (HP:0100614)4.29151590
14Autoimmune hemolytic anemia (HP:0001890)4.19362244
15Abnormality of T cells (HP:0002843)4.10778180
16Recurrent viral infections (HP:0004429)4.03800592
17Chronic mucocutaneous candidiasis (HP:0002728)4.01651398
18Recurrent cutaneous fungal infections (HP:0011370)4.01651398
19Mediastinal lymphadenopathy (HP:0100721)3.88684324
20Increased IgM level (HP:0003496)3.84752872
21Granulocytopenia (HP:0001913)3.83312932
22Vasculitis (HP:0002633)3.82818409
23Abnormality of macrophages (HP:0004311)3.74404283
24Abnormality of T cell physiology (HP:0011840)3.72913272
25Encephalitis (HP:0002383)3.70050294
26Increased IgE level (HP:0003212)3.62926636
27Severe combined immunodeficiency (HP:0004430)3.58956445
28Autoimmune thrombocytopenia (HP:0001973)3.57828398
29Cellulitis (HP:0100658)3.55541361
30Recurrent skin infections (HP:0001581)3.51801032
31Pustule (HP:0200039)3.50500203
32Chronic obstructive pulmonary disease (HP:0006510)3.50433479
33Obstructive lung disease (HP:0006536)3.50433479
34Abnormality of cells of the lymphoid lineage (HP:0012140)3.48275202
35IgM deficiency (HP:0002850)3.45500441
36Lymphopenia (HP:0001888)3.45298525
37Orchitis (HP:0100796)3.42372134
38Optic neuritis (HP:0100653)3.42254959
39Retrobulbar optic neuritis (HP:0100654)3.42254959
40Eosinophilia (HP:0001880)3.40759689
41Inflammation of the large intestine (HP:0002037)3.34161749
42Gastrointestinal inflammation (HP:0004386)3.34021895
43IgG deficiency (HP:0004315)3.30922076
44Verrucae (HP:0200043)3.30637644
45Papilloma (HP:0012740)3.30637644
46Spontaneous hematomas (HP:0007420)3.26832867
47Gastrointestinal infarctions (HP:0005244)3.26720931
48Leukocytosis (HP:0001974)3.25615034
49Colitis (HP:0002583)3.20769084
50Gastrointestinal stroma tumor (HP:0100723)3.19798376
51Abnormality of B cell number (HP:0010975)3.19534156
52Recurrent bronchitis (HP:0002837)3.15546054
53Abnormality of eosinophils (HP:0001879)3.15469690
54Prolonged bleeding time (HP:0003010)3.10920949
55B lymphocytopenia (HP:0010976)3.06719515
56Recurrent gram-negative bacterial infections (HP:0005420)3.06153726
57Urticaria (HP:0001025)2.96730119
58Hypochromic anemia (HP:0001931)2.96199441
59Combined immunodeficiency (HP:0005387)2.95030217
60Chest pain (HP:0100749)2.93791493
61Pulmonary infiltrates (HP:0002113)2.80231363
62Hypergammaglobulinemia (HP:0010702)2.74554561
63Epistaxis (HP:0000421)2.67362077
64Osteomyelitis (HP:0002754)2.65450868
65Abnormality of the fingertips (HP:0001211)2.64525099
66Recurrent sinusitis (HP:0011108)2.62253396
67Sepsis (HP:0100806)2.60571237
68Keratoconjunctivitis sicca (HP:0001097)2.58552711
69Keratoconjunctivitis (HP:0001096)2.55624228
70Papilledema (HP:0001085)2.47607628
71Chronic diarrhea (HP:0002028)2.46745825
72Hemoptysis (HP:0002105)2.46027710
73Abnormality of the prostate (HP:0008775)2.39131580
74Gingivitis (HP:0000230)2.38418910
75Lymphoma (HP:0002665)2.38203561
76Chronic otitis media (HP:0000389)2.32930976
77Viral hepatitis (HP:0006562)2.30087133
78Petechiae (HP:0000967)2.22211358
79Skin rash (HP:0000988)2.21899379
80Gingival bleeding (HP:0000225)2.20853144
81Pulmonary embolism (HP:0002204)2.20690614
82Arterial thrombosis (HP:0004420)2.19109485
83Slow saccadic eye movements (HP:0000514)2.14785513
84Fatigue (HP:0012378)2.13269056
85IgA deficiency (HP:0002720)2.11477436
86Skin ulcer (HP:0200042)2.11360949
87Hypoplasia of the thymus (HP:0000778)2.11246881
88Aplasia/Hypoplasia of the thymus (HP:0010515)2.10064943
89Basal cell carcinoma (HP:0002671)2.08596609
90Abnormality of the pleura (HP:0002103)2.08452993
91Thrombocytosis (HP:0001894)2.07381641
92Joint swelling (HP:0001386)2.06198134
93Restrictive lung disease (HP:0002091)2.06074035
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04261667
95Episodic fever (HP:0001954)2.04202744
96Recurrent lower respiratory tract infections (HP:0002783)1.96024036
97Acute hepatic failure (HP:0006554)1.95229236
98Recurrent pneumonia (HP:0006532)1.94001742
99Neutropenia (HP:0001875)1.90952230
100Anorexia (HP:0002039)1.87975647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.16403382
2RIPK43.76436404
3PRPF4B3.23037731
4TXK2.55924619
5FES2.55218167
6TYK22.42224020
7GRK62.38002420
8BTK2.28699431
9ERN12.26058744
10TAOK32.23052316
11BLK2.15701555
12SYK2.13890564
13MAP3K142.13318207
14ITK2.04156462
15ZAP702.03212384
16KIT1.96544535
17IRAK41.95877530
18MAP2K31.89756304
19MAP3K131.85962181
20IKBKE1.79771390
21TNK21.77333779
22JAK31.75706343
23MAP3K101.75351140
24CSK1.73521547
25PASK1.62670492
26CSF1R1.60914979
27LCK1.58097844
28JAK11.54145805
29HCK1.53871673
30TEC1.52636013
31SIK21.46514833
32SIK31.44186024
33MARK31.43058396
34TBK11.42961015
35LYN1.41841789
36STK101.38957213
37CDK121.32483664
38IKBKB1.27962622
39TESK21.20087179
40TLK11.09220069
41MAPK121.08305919
42CDK41.07675413
43PRKCQ1.04809955
44CAMKK11.03604244
45SMG11.00746107
46PIM10.99949634
47BMPR20.98590421
48JAK20.97313065
49CAMKK20.94918360
50MAP3K110.94368397
51CDK190.94247761
52HIPK20.82804382
53MAPK70.80912245
54PDK10.80379805
55MAPK110.79466102
56NLK0.79017814
57FGR0.78301097
58TRIB30.75526195
59KDR0.71174038
60FGFR40.71153964
61FGFR30.70909451
62MAP2K20.69558844
63MAP3K10.68397026
64MARK20.66975191
65MAP3K70.66655466
66EPHB10.64089705
67LRRK20.63548010
68PIK3CG0.63376742
69CDK60.61631174
70TAOK10.53451398
71MATK0.52463135
72FYN0.52054724
73RET0.51579578
74MAP3K30.50838977
75PRKD20.50399104
76CDC42BPA0.49755067
77PIK3CA0.46457799
78TAOK20.45765244
79BRD40.44610365
80IRAK10.44240523
81MAP3K60.42782913
82YES10.41457951
83RPS6KC10.39059465
84RPS6KL10.39059465
85EEF2K0.36625966
86SIK10.36268159
87PRKCH0.36107272
88MELK0.35744333
89MAPK40.35468596
90PDPK10.34423262
91STK110.34323666
92RPS6KA60.33219964
93MAP2K60.31410644
94IRAK20.29925421
95SCYL20.29674596
96MAPK30.28609943
97MAPKAPK20.27817985
98MAP3K50.27671470
99CHUK0.26988467
100ABL10.24457386

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.23180560
2Allograft rejection_Homo sapiens_hsa053303.31854357
3Graft-versus-host disease_Homo sapiens_hsa053323.25729164
4Autoimmune thyroid disease_Homo sapiens_hsa053203.13686412
5B cell receptor signaling pathway_Homo sapiens_hsa046622.83573048
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.60236713
7Leishmaniasis_Homo sapiens_hsa051402.50687296
8T cell receptor signaling pathway_Homo sapiens_hsa046602.49092870
9Type I diabetes mellitus_Homo sapiens_hsa049402.44022024
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.43853028
11Osteoclast differentiation_Homo sapiens_hsa043802.35259743
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26144575
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.13069745
14Measles_Homo sapiens_hsa051622.08616504
15Antigen processing and presentation_Homo sapiens_hsa046122.07989783
16Asthma_Homo sapiens_hsa053102.03228741
17Hematopoietic cell lineage_Homo sapiens_hsa046401.94664890
18Acute myeloid leukemia_Homo sapiens_hsa052211.93315463
19Viral myocarditis_Homo sapiens_hsa054161.86126646
20Staphylococcus aureus infection_Homo sapiens_hsa051501.83871557
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76952891
22Herpes simplex infection_Homo sapiens_hsa051681.74709651
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66004976
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.65073969
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62952951
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57597115
27Influenza A_Homo sapiens_hsa051641.52817221
28Tuberculosis_Homo sapiens_hsa051521.50429198
29Toxoplasmosis_Homo sapiens_hsa051451.46709177
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.39760801
31Non-small cell lung cancer_Homo sapiens_hsa052231.36054546
32Hepatitis B_Homo sapiens_hsa051611.34393465
33Chemokine signaling pathway_Homo sapiens_hsa040621.25814223
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23906641
35TNF signaling pathway_Homo sapiens_hsa046681.23300085
36Malaria_Homo sapiens_hsa051441.18546122
37Epstein-Barr virus infection_Homo sapiens_hsa051691.10587735
38Other glycan degradation_Homo sapiens_hsa005111.09754033
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08358306
40Apoptosis_Homo sapiens_hsa042101.04082026
41Platelet activation_Homo sapiens_hsa046111.04067989
42African trypanosomiasis_Homo sapiens_hsa051431.03681611
43Chronic myeloid leukemia_Homo sapiens_hsa052201.02631162
44Pancreatic cancer_Homo sapiens_hsa052121.00361696
45Rheumatoid arthritis_Homo sapiens_hsa053230.95151824
46HTLV-I infection_Homo sapiens_hsa051660.90545325
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.88917588
48Hepatitis C_Homo sapiens_hsa051600.88355415
49Viral carcinogenesis_Homo sapiens_hsa052030.87379297
50Legionellosis_Homo sapiens_hsa051340.86235972
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81089847
52Shigellosis_Homo sapiens_hsa051310.80860205
53VEGF signaling pathway_Homo sapiens_hsa043700.79491855
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78990493
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.78971850
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78135260
57Colorectal cancer_Homo sapiens_hsa052100.72588407
58Prolactin signaling pathway_Homo sapiens_hsa049170.72015132
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68227175
60FoxO signaling pathway_Homo sapiens_hsa040680.66746708
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63040574
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61382695
63mTOR signaling pathway_Homo sapiens_hsa041500.60731005
64Renal cell carcinoma_Homo sapiens_hsa052110.60127298
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56928934
66Pertussis_Homo sapiens_hsa051330.56385498
67Phagosome_Homo sapiens_hsa041450.56225703
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.56219087
69Systemic lupus erythematosus_Homo sapiens_hsa053220.55640037
70Inositol phosphate metabolism_Homo sapiens_hsa005620.53996446
71Endometrial cancer_Homo sapiens_hsa052130.51894429
72Choline metabolism in cancer_Homo sapiens_hsa052310.50678419
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50433449
74MAPK signaling pathway_Homo sapiens_hsa040100.50355825
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49472571
76Prostate cancer_Homo sapiens_hsa052150.43705373
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.43509523
78Insulin resistance_Homo sapiens_hsa049310.39202217
79Salmonella infection_Homo sapiens_hsa051320.38436613
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.37825663
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37529024
82Endocytosis_Homo sapiens_hsa041440.37309874
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32844174
84Notch signaling pathway_Homo sapiens_hsa043300.32739762
85Dorso-ventral axis formation_Homo sapiens_hsa043200.31733792
86HIF-1 signaling pathway_Homo sapiens_hsa040660.31249127
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28629366
88ErbB signaling pathway_Homo sapiens_hsa040120.28107683
89Type II diabetes mellitus_Homo sapiens_hsa049300.28050794
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.26745935
91Small cell lung cancer_Homo sapiens_hsa052220.25220092
92Regulation of autophagy_Homo sapiens_hsa041400.24797429
93Glioma_Homo sapiens_hsa052140.24259791
94GnRH signaling pathway_Homo sapiens_hsa049120.24036596
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21926436
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20234380
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20035896
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17984165
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17814767
100Ras signaling pathway_Homo sapiens_hsa040140.17166204

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