P3H1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.85190622
2protein heterotrimerization (GO:0070208)6.03424796
3cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.76278651
4chondrocyte proliferation (GO:0035988)5.12897232
5bone trabecula formation (GO:0060346)5.01707037
6skin morphogenesis (GO:0043589)4.75235522
7endodermal cell differentiation (GO:0035987)4.69319935
8chondrocyte development (GO:0002063)4.54504674
9collagen metabolic process (GO:0032963)4.52017822
10collagen catabolic process (GO:0030574)4.45580916
11peptidyl-proline hydroxylation (GO:0019511)4.32055122
12COPI coating of Golgi vesicle (GO:0048205)4.30302579
13Golgi transport vesicle coating (GO:0048200)4.30302579
14keratan sulfate catabolic process (GO:0042340)4.29244134
15blood vessel maturation (GO:0001955)4.21561174
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.20449239
17multicellular organismal macromolecule metabolic process (GO:0044259)4.20126697
18basement membrane organization (GO:0071711)4.19106107
19multicellular organismal catabolic process (GO:0044243)4.06709492
20protein retention in ER lumen (GO:0006621)4.04771995
21notochord development (GO:0030903)4.00612395
22multicellular organismal metabolic process (GO:0044236)3.95836885
23heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.91634620
24substrate-dependent cell migration (GO:0006929)3.83801136
25extracellular matrix disassembly (GO:0022617)3.82007214
26protein hydroxylation (GO:0018126)3.76293226
27sequestering of extracellular ligand from receptor (GO:0035581)3.75518315
28lymphangiogenesis (GO:0001946)3.69853410
29type B pancreatic cell proliferation (GO:0044342)3.58868585
30cell aggregation (GO:0098743)3.50819423
31cartilage condensation (GO:0001502)3.50819423
32endothelial cell morphogenesis (GO:0001886)3.49615456
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.46830295
34positive regulation of endothelial cell apoptotic process (GO:2000353)3.44619177
35negative regulation of chondrocyte differentiation (GO:0032331)3.43587146
36negative regulation of fatty acid transport (GO:2000192)3.42739714
37positive regulation of osteoblast proliferation (GO:0033690)3.42174705
38negative regulation of axon extension involved in axon guidance (GO:0048843)3.41276397
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.41030025
40embryonic skeletal joint morphogenesis (GO:0060272)3.38258917
41positive regulation of extracellular matrix organization (GO:1903055)3.38069019
42paraxial mesoderm development (GO:0048339)3.36929855
43polarized epithelial cell differentiation (GO:0030859)3.34181954
44negative regulation of cartilage development (GO:0061037)3.33323277
45wound healing, spreading of epidermal cells (GO:0035313)3.29924667
46craniofacial suture morphogenesis (GO:0097094)3.27843537
47tooth mineralization (GO:0034505)3.26862001
48glomerular basement membrane development (GO:0032836)3.25953936
49apoptotic cell clearance (GO:0043277)3.24618480
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.22988753
51outer ear morphogenesis (GO:0042473)3.20693156
52extracellular regulation of signal transduction (GO:1900115)3.18442441
53extracellular negative regulation of signal transduction (GO:1900116)3.18442441
54sprouting angiogenesis (GO:0002040)3.17375735
55neuron projection extension involved in neuron projection guidance (GO:1902284)3.16958899
56axon extension involved in axon guidance (GO:0048846)3.16958899
57positive regulation of epithelial to mesenchymal transition (GO:0010718)3.16787648
58negative regulation of smooth muscle cell migration (GO:0014912)3.13493729
59epithelial cell-cell adhesion (GO:0090136)3.11924423
60COPII vesicle coating (GO:0048208)3.11902006
61cell adhesion mediated by integrin (GO:0033627)3.06218190
62virion attachment to host cell (GO:0019062)3.05573993
63adhesion of symbiont to host cell (GO:0044650)3.05573993
64venous blood vessel morphogenesis (GO:0048845)3.05061903
65adhesion of symbiont to host (GO:0044406)3.04696357
66endocardial cushion development (GO:0003197)3.03644481
67cellular response to vitamin D (GO:0071305)3.00247322
68cochlea morphogenesis (GO:0090103)2.98532053
69regulation of SMAD protein import into nucleus (GO:0060390)2.98430360
70positive regulation of cartilage development (GO:0061036)2.97523166
71positive regulation of blood vessel endothelial cell migration (GO:0043536)2.97091830
72hyaluronan catabolic process (GO:0030214)2.96506054
73negative regulation of axon guidance (GO:1902668)2.95710566
74G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.94952895
75regulation of cartilage development (GO:0061035)2.94872910
76replacement ossification (GO:0036075)2.94454708
77endochondral ossification (GO:0001958)2.94454708
78hippo signaling (GO:0035329)2.94309292
79mesodermal cell differentiation (GO:0048333)2.93767723
80activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.93513907
81dermatan sulfate biosynthetic process (GO:0030208)2.92580638
82endosome to melanosome transport (GO:0035646)2.92534266
83endosome to pigment granule transport (GO:0043485)2.92534266
84extracellular matrix organization (GO:0030198)2.92290314
85extracellular matrix assembly (GO:0085029)2.91636075
86regulation of plasminogen activation (GO:0010755)2.91578515
87extracellular structure organization (GO:0043062)2.91426354
88cellular response to vitamin (GO:0071295)2.89327974
894-hydroxyproline metabolic process (GO:0019471)2.89117873
90extracellular fibril organization (GO:0043206)2.87377400
91mesenchymal-epithelial cell signaling (GO:0060638)2.85363953
92endothelial cell proliferation (GO:0001935)2.85189537
93positive regulation of nuclease activity (GO:0032075)2.83912588
94UV protection (GO:0009650)2.79569858
95positive regulation of SMAD protein import into nucleus (GO:0060391)2.78997106
96UDP-N-acetylglucosamine metabolic process (GO:0006047)2.77841113
97cell migration involved in heart development (GO:0060973)2.77137894
98heparan sulfate proteoglycan metabolic process (GO:0030201)2.77050869
99pericardium development (GO:0060039)2.75853188
100cranial suture morphogenesis (GO:0060363)2.75327177
101smooth muscle tissue development (GO:0048745)2.75053972
102regulation of chondrocyte differentiation (GO:0032330)2.74670777
103fibril organization (GO:0097435)2.73770339
104Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.73124499
105negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.72385078
106establishment of apical/basal cell polarity (GO:0035089)2.71493231
107regulation of gastrulation (GO:0010470)2.70643698
108facial nerve structural organization (GO:0021612)2.69299756
109regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.69012328
110metanephric mesenchyme development (GO:0072075)2.68564593
111protein carboxylation (GO:0018214)2.68486522
112peptidyl-glutamic acid carboxylation (GO:0017187)2.68486522
113negative chemotaxis (GO:0050919)2.67858365
114hemidesmosome assembly (GO:0031581)2.67540191
115wound healing, spreading of cells (GO:0044319)2.66538187
116cell migration involved in sprouting angiogenesis (GO:0002042)2.66075445
117dermatan sulfate metabolic process (GO:0030205)2.65806474
118negative regulation of fibrinolysis (GO:0051918)2.65218127
119proteoglycan biosynthetic process (GO:0030166)2.64494971
120substrate adhesion-dependent cell spreading (GO:0034446)2.64476942
121regulation of axon extension involved in axon guidance (GO:0048841)2.63660113
122vascular endothelial growth factor signaling pathway (GO:0038084)2.60636100
123chondroitin sulfate biosynthetic process (GO:0030206)2.60514145
124positive regulation of axon extension (GO:0045773)2.60422294
125blood vessel endothelial cell migration (GO:0043534)2.59843731
126positive regulation of chondrocyte differentiation (GO:0032332)2.58464374
127osteoblast differentiation (GO:0001649)2.58246508
128kidney mesenchyme development (GO:0072074)2.57828785
129cartilage development (GO:0051216)2.57608631
130retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57412163
131regulation of nuclease activity (GO:0032069)2.54189982
132regulation of hippo signaling (GO:0035330)2.53670542
133endoplasmic reticulum unfolded protein response (GO:0030968)2.53511837
134regulation of tight junction assembly (GO:2000810)2.52933697
135middle ear morphogenesis (GO:0042474)2.51732570
136regulation of extracellular matrix disassembly (GO:0010715)2.51545232
137anatomical structure regression (GO:0060033)2.51290739
138trabecula formation (GO:0060343)2.48932671
139positive regulation of stem cell differentiation (GO:2000738)2.48424837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.65968677
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.57264844
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.04938068
4CLOCK_20551151_ChIP-Seq_293T_Human3.13578210
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.80419996
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.79270234
7RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.77116039
8E2F7_22180533_ChIP-Seq_HELA_Human2.73156627
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64021036
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.59495512
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.49628486
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.46604812
13JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.41122079
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35179592
15TP53_16413492_ChIP-PET_HCT116_Human2.23453240
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.16356266
17JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.12205161
18ZNF274_21170338_ChIP-Seq_K562_Hela2.11792516
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.11281427
20GATA2_21666600_ChIP-Seq_HMVEC_Human2.07705691
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.04096454
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.99808576
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.97913010
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.92862898
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88720068
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86863482
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.83644316
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.81847300
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79625010
30SA1_22415368_ChIP-Seq_MEFs_Mouse1.76676774
31BRD4_25478319_ChIP-Seq_HGPS_Human1.74681320
32AR_21909140_ChIP-Seq_LNCAP_Human1.72976529
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.72971133
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72589319
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71479938
36TP53_18474530_ChIP-ChIP_U2OS_Human1.70319444
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.68726117
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.68347410
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.68347410
40ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.67799416
41ATF3_27146783_Chip-Seq_COLON_Human1.67080924
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65122452
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62246597
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59592765
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57893366
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57118099
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55794723
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.54231571
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53809532
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53362452
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53263902
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51786898
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51555679
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51408711
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50382914
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49555785
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49555785
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49555785
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.48932524
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.47793411
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47703078
62ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.46091048
63TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45194371
64NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.43720780
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43265896
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39822106
67TP53_22127205_ChIP-Seq_IMR90_Human1.39447414
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38194277
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38017068
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36722112
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35233594
72MYC_22102868_ChIP-Seq_BL_Human1.35136651
73CJUN_26792858_Chip-Seq_BT549_Human1.34892703
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33222208
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.32978994
76UBF1/2_26484160_Chip-Seq_HMECs_Human1.32740205
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32638596
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32352693
79RACK7_27058665_Chip-Seq_MCF-7_Human1.29927734
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28599975
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.27102349
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25590093
83PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.24330086
84LXR_22292898_ChIP-Seq_THP-1_Human1.23012459
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22753553
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22716754
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22700650
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22265774
89MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22162684
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20998286
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20227825
92SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19556798
93EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19466910
94PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19409180
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17601526
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17393614
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17393614
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15129601
99ELK1_22589737_ChIP-Seq_MCF10A_Human1.14724862
100RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14700640
101EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14700640
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13881598
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13468494
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13392021
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13154699
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10624608
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.10060964
108MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09907964
109SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.09448633
110SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09054023
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08833950
112XRN2_22483619_ChIP-Seq_HELA_Human1.06420172
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04959966
114NFI_21473784_ChIP-Seq_ESCs_Mouse1.04613607
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04517457
116TP53_23651856_ChIP-Seq_MEFs_Mouse1.04491454
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03646715
118MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03296441
119E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02305761
120ISL1_27105846_Chip-Seq_CPCs_Mouse1.01718803
121ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01525603
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01349306
123TET1_21490601_ChIP-Seq_MESCs_Mouse1.00662866
124TBX20_22328084_ChIP-Seq_HEART_Mouse0.99462684
125TBX20_22080862_ChIP-Seq_HEART_Mouse0.99462684
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.99112936
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98487042
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98386958
129TFEB_21752829_ChIP-Seq_HELA_Human0.98098220
130FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97903059
131KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97157625
132TP63_19390658_ChIP-ChIP_HaCaT_Human0.96773636
133KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95729764
134SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95137649
135CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94701439
136SOX11_22085726_ChIP-Seq_ESNs_Mouse0.91046661
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90900610
138TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90872884
139GBX2_23144817_ChIP-Seq_PC3_Human0.90239064
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87399089
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83893732
142TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82763949
143TBX3_20139965_ChIP-Seq_MESCs_Mouse0.81153663
144P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80571588
145CSB_26484114_Chip-Seq_FIBROBLAST_Human0.79785158
146RARA_24833708_ChIP-Seq_LIVER_Mouse0.79040585
147PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.78477011
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.73389090
149OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.71528769
150SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.71130364
151GATA4_21415370_ChIP-Seq_HL-1_Mouse0.70428721
152PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69616875
153MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.69483457
154EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.68843222
155MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.68798734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.78433799
2MP0005503_abnormal_tendon_morphology4.95080215
3MP0005275_abnormal_skin_tensile4.03996739
4MP0003705_abnormal_hypodermis_morpholog3.89121308
5MP0003279_aneurysm3.18765940
6MP0004272_abnormal_basement_membrane3.07977165
7MP0003283_abnormal_digestive_organ2.61216445
8MP0009384_cardiac_valve_regurgitation2.27320099
9MP0006054_spinal_hemorrhage2.26251890
10MP0005508_abnormal_skeleton_morphology2.22649955
11MP0005623_abnormal_meninges_morphology2.20907731
12MP0001958_emphysema2.17885536
13MP0004134_abnormal_chest_morphology2.11929921
14MP0010030_abnormal_orbit_morphology2.08263688
15MP0002282_abnormal_trachea_morphology2.02674067
16MP0003566_abnormal_cell_adhesion2.01539392
17MP0003950_abnormal_plasma_membrane1.98339782
18MP0009250_abnormal_appendicular_skeleto1.95607579
19MP0005257_abnormal_intraocular_pressure1.92242558
20MP0002896_abnormal_bone_mineralization1.86429403
21MP0005023_abnormal_wound_healing1.78880863
22MP0002933_joint_inflammation1.75557082
23MP0000163_abnormal_cartilage_morphology1.74594705
24MP0001542_abnormal_bone_strength1.70272800
25MP0010352_gastrointestinal_tract_polyps1.68959832
26MP0009053_abnormal_anal_canal1.67062536
27MP0002108_abnormal_muscle_morphology1.62911434
28MP0005171_absent_coat_pigmentation1.59012921
29MP0003385_abnormal_body_wall1.57601230
30MP0002115_abnormal_skeleton_extremities1.56749090
31MP0002060_abnormal_skin_morphology1.49228143
32MP0002932_abnormal_joint_morphology1.40059621
33MP0003942_abnormal_urinary_system1.39740527
34MP0002113_abnormal_skeleton_development1.37765388
35MP0001243_abnormal_dermal_layer1.34716214
36MP0000733_abnormal_muscle_development1.33322707
37MP0004858_abnormal_nervous_system1.33141417
38MP0005390_skeleton_phenotype1.33140363
39MP0003091_abnormal_cell_migration1.33101807
40MP0003123_paternal_imprinting1.29421467
41MP0001879_abnormal_lymphatic_vessel1.27416055
42MP0000428_abnormal_craniofacial_morphol1.26687721
43MP0005595_abnormal_vascular_smooth1.25466238
44MP0002295_abnormal_pulmonary_circulatio1.24427254
45MP0010368_abnormal_lymphatic_system1.22928125
46MP0001299_abnormal_eye_distance/1.21550483
47MP0000049_abnormal_middle_ear1.20281399
48MP0005076_abnormal_cell_differentiation1.16950019
49MP0002089_abnormal_postnatal_growth/wei1.16487260
50MP0004197_abnormal_fetal_growth/weight/1.14250609
51MP0000534_abnormal_ureter_morphology1.13254986
52MP0000751_myopathy1.13203978
53MP0000767_abnormal_smooth_muscle1.12876816
54MP0003755_abnormal_palate_morphology1.12516664
55MP0002938_white_spotting1.12179820
56MP0002109_abnormal_limb_morphology1.11567518
57MP0002249_abnormal_larynx_morphology1.11170528
58MP0003115_abnormal_respiratory_system1.10880741
59MP0004084_abnormal_cardiac_muscle1.10474587
60MP0002111_abnormal_tail_morphology1.10288855
61MP0005197_abnormal_uvea_morphology1.09885779
62MP0005058_abnormal_lysosome_morphology1.09021725
63MP0009840_abnormal_foam_cell1.08068084
64MP0003941_abnormal_skin_development1.07156499
65MP0002877_abnormal_melanocyte_morpholog1.05034346
66MP0000762_abnormal_tongue_morphology1.04994483
67MP0002116_abnormal_craniofacial_bone1.04321478
68MP0003935_abnormal_craniofacial_develop1.03680095
69MP0000432_abnormal_head_morphology1.02884597
70MP0003122_maternal_imprinting1.02615632
71MP0002233_abnormal_nose_morphology1.02014107
72MP0003937_abnormal_limbs/digits/tail_de1.00923375
73MP0000750_abnormal_muscle_regeneration0.98516328
74MP0001915_intracranial_hemorrhage0.97989112
75MP0000537_abnormal_urethra_morphology0.97861518
76MP0001661_extended_life_span0.96979878
77MP0000013_abnormal_adipose_tissue0.95495918
78MP0003795_abnormal_bone_structure0.93160125
79MP0000538_abnormal_urinary_bladder0.88564638
80MP0010386_abnormal_urinary_bladder0.86934287
81MP0002653_abnormal_ependyma_morphology0.85078362
82MP0002114_abnormal_axial_skeleton0.82966094
83MP0002998_abnormal_bone_remodeling0.81889764
84MP0003119_abnormal_digestive_system0.81816604
85MP0002128_abnormal_blood_circulation0.81747050
86MP0004185_abnormal_adipocyte_glucose0.81725969
87MP0005360_urolithiasis0.81588453
88MP0001533_abnormal_skeleton_physiology0.79880436
89MP0002697_abnormal_eye_size0.78595977
90MP0004233_abnormal_muscle_weight0.76491133
91MP0001614_abnormal_blood_vessel0.76260986
92MP0001849_ear_inflammation0.75866110
93MP0002084_abnormal_developmental_patter0.73964038
94MP0000003_abnormal_adipose_tissue0.73106897
95MP0000462_abnormal_digestive_system0.72877499
96MP0002925_abnormal_cardiovascular_devel0.72169347
97MP0008007_abnormal_cellular_replicative0.71280955
98MP0002254_reproductive_system_inflammat0.70935688
99MP0003567_abnormal_fetal_cardiomyocyte0.70923188
100MP0009780_abnormal_chondrocyte_physiolo0.70673336
101MP0003806_abnormal_nucleotide_metabolis0.70505875
102MP0001175_abnormal_lung_morphology0.70255455
103MP0004087_abnormal_muscle_fiber0.70013874
104MP0002085_abnormal_embryonic_tissue0.69558433
105MP0002168_other_aberrant_phenotype0.69087940
106MP0002088_abnormal_embryonic_growth/wei0.67311901
107MP0002086_abnormal_extraembryonic_tissu0.67062886
108MP0003984_embryonic_growth_retardation0.66631597
109MP0006138_congestive_heart_failure0.66397773
110MP0005220_abnormal_exocrine_pancreas0.65805942
111MP0005367_renal/urinary_system_phenotyp0.64888178
112MP0000516_abnormal_urinary_system0.64888178
113MP0001270_distended_abdomen0.64815609
114MP0000759_abnormal_skeletal_muscle0.63863374
115MP0005193_abnormal_anterior_eye0.63285587
116MP0001672_abnormal_embryogenesis/_devel0.62895548
117MP0003172_abnormal_lysosome_physiology0.60133156
118MP0004133_heterotaxia0.59012078
119MP0005164_abnormal_response_to0.54808708
120MP0001348_abnormal_lacrimal_gland0.54547930
121MP0002092_abnormal_eye_morphology0.52528199
122MP0002160_abnormal_reproductive_system0.50042048
123MP0002135_abnormal_kidney_morphology0.47200325
124MP0002177_abnormal_outer_ear0.45820198
125MP0002102_abnormal_ear_morphology0.44120744
126MP0008775_abnormal_heart_ventricle0.44104826

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.50659918
2Premature rupture of membranes (HP:0001788)6.57927697
3Neonatal short-limb short stature (HP:0008921)4.41453930
4Epiphyseal dysplasia (HP:0002656)4.34115455
5Ankle contracture (HP:0006466)3.99343961
6Cervical subluxation (HP:0003308)3.82228925
7Hypoplastic ischia (HP:0003175)3.78856069
8Vascular tortuosity (HP:0004948)3.73474898
9Aortic dissection (HP:0002647)3.71516787
10Soft skin (HP:0000977)3.71321361
11Shallow orbits (HP:0000586)3.69859074
12Peritonitis (HP:0002586)3.67467974
13Biconcave vertebral bodies (HP:0004586)3.52073894
14Irregular epiphyses (HP:0010582)3.51384248
15Abnormality of dentin (HP:0010299)3.50422548
16Genu recurvatum (HP:0002816)3.45469647
17Cupped ribs (HP:0000887)3.43818680
18Vitreoretinal degeneration (HP:0000655)3.39189087
19Atrophic scars (HP:0001075)3.37465539
20Arterial tortuosity (HP:0005116)3.33427488
21Abnormality of the ischium (HP:0003174)3.29357352
22Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.24675656
23Metaphyseal cupping (HP:0003021)3.23538827
24Cerebral aneurysm (HP:0004944)3.21335353
25Bladder diverticulum (HP:0000015)3.20695886
26Osteoarthritis (HP:0002758)3.18418791
27Blue sclerae (HP:0000592)3.15822743
28Wormian bones (HP:0002645)3.08696945
29Mild short stature (HP:0003502)3.06971961
30Spondylolisthesis (HP:0003302)2.98820283
31Vertebral compression fractures (HP:0002953)2.97942050
32Coxa vara (HP:0002812)2.93374787
33Mitral valve prolapse (HP:0001634)2.92855382
34Small epiphyses (HP:0010585)2.89369915
35Abnormality of the acetabulum (HP:0003170)2.86890533
36Type 1 muscle fiber predominance (HP:0003803)2.84328251
37Broad metatarsal (HP:0001783)2.84043237
38Dilatation of the ascending aorta (HP:0005111)2.80415611
39Platyspondyly (HP:0000926)2.79751020
40Breech presentation (HP:0001623)2.76891010
41Follicular hyperkeratosis (HP:0007502)2.73287877
42Flat acetabular roof (HP:0003180)2.72920238
43Aortic aneurysm (HP:0004942)2.72513457
44Delayed epiphyseal ossification (HP:0002663)2.69456914
45Mesomelia (HP:0003027)2.69203485
46Fragile skin (HP:0001030)2.69058026
47Abnormal tarsal ossification (HP:0008369)2.61635286
48Spinal rigidity (HP:0003306)2.59291477
49Flat capital femoral epiphysis (HP:0003370)2.58867154
50Keratoconus (HP:0000563)2.56684729
51Increased corneal curvature (HP:0100692)2.56684729
52Abnormal delivery (HP:0001787)2.55807064
53Aortic regurgitation (HP:0001659)2.53909749
54Ulnar bowing (HP:0003031)2.47493278
55Premature skin wrinkling (HP:0100678)2.44395932
56Ectopia lentis (HP:0001083)2.42298443
57Disproportionate tall stature (HP:0001519)2.37731872
58Beaking of vertebral bodies (HP:0004568)2.35403058
59Inguinal hernia (HP:0000023)2.35367579
60Hip contracture (HP:0003273)2.33202829
61Wide anterior fontanel (HP:0000260)2.32348679
62Bell-shaped thorax (HP:0001591)2.30850102
63Broad long bones (HP:0005622)2.30635406
64Genu varum (HP:0002970)2.27615219
65Hypoventilation (HP:0002791)2.27158173
66Exostoses (HP:0100777)2.27103183
67Increased connective tissue (HP:0009025)2.26865224
68Flat cornea (HP:0007720)2.25392815
69Abnormal vertebral ossification (HP:0100569)2.25248085
70Aortic valve stenosis (HP:0001650)2.25247050
71Hyperextensible skin (HP:0000974)2.23576840
72Thoracolumbar scoliosis (HP:0002944)2.22381991
73Abnormal foot bone ossification (HP:0010675)2.21872732
74Renal duplication (HP:0000075)2.20127136
75Mitral regurgitation (HP:0001653)2.19496582
76Joint laxity (HP:0001388)2.12209537
77Elbow flexion contracture (HP:0002987)2.11326515
78Spinal cord compression (HP:0002176)2.09499509
79Radial bowing (HP:0002986)2.09325747
80Abnormality of the calcaneus (HP:0008364)2.08911583
81Bowel diverticulosis (HP:0005222)2.08554498
82Short nail (HP:0001799)2.08472265
83Limited hip movement (HP:0008800)2.07930216
84Flattened epiphyses (HP:0003071)2.07897739
85Slender build (HP:0001533)2.07362470
86Abnormality of carpal bone ossification (HP:0006257)2.07074603
87Wrist flexion contracture (HP:0001239)2.06370584
88Abnormal ossification of hand bones (HP:0005921)2.05535724
89Tibial bowing (HP:0002982)2.05457451
90Thin ribs (HP:0000883)2.04809247
91Mildly elevated creatine phosphokinase (HP:0008180)2.03120190
92Protruding ear (HP:0000411)2.02858276
93Mitral stenosis (HP:0001718)2.02010041
94Decreased skull ossification (HP:0004331)2.01496614
95Vertebral clefting (HP:0008428)1.98785381
96Broad phalanx (HP:0006009)1.97987215
97Infantile muscular hypotonia (HP:0008947)1.96582228
98Long toe (HP:0010511)1.96516841
99Limited elbow extension (HP:0001377)1.95584050
100Abnormality of the proximal phalanges of the hand (HP:0009834)1.95492150
101Knee flexion contracture (HP:0006380)1.95313808
102Lumbar hyperlordosis (HP:0002938)1.95142531
103Redundant skin (HP:0001582)1.95093022
104Rhizomelia (HP:0008905)1.94936421
105Distal upper limb amyotrophy (HP:0007149)1.94514769
106Upper limb amyotrophy (HP:0009129)1.94514769
107Deviation of the hallux (HP:0010051)1.94226896
108Hand muscle atrophy (HP:0009130)1.93222394
109Coronal craniosynostosis (HP:0004440)1.92498980
110Aneurysm (HP:0002617)1.92212585
111Overgrowth (HP:0001548)1.92001063
112Nonimmune hydrops fetalis (HP:0001790)1.91029106
113Joint stiffness (HP:0001387)1.90912200
114Hallux valgus (HP:0001822)1.90739995
115Natal tooth (HP:0000695)1.88960374
116Camptodactyly of toe (HP:0001836)1.88705669
117Abnormality of skull ossification (HP:0002703)1.88514189
118Broad thumb (HP:0011304)1.88409058
119Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.87536932
120Abnormality of femoral epiphyses (HP:0006499)1.87536932
121Ovoid vertebral bodies (HP:0003300)1.87010764
122Broad ribs (HP:0000885)1.84808243
123Delayed closure of the anterior fontanelle (HP:0001476)1.84341072
124Bowed forearm bones (HP:0003956)1.83888826
125Bowing of the arm (HP:0006488)1.83888826
126Morphological abnormality of the middle ear (HP:0008609)1.83286587
127Slender long bone (HP:0003100)1.80787052
128Venous insufficiency (HP:0005293)1.80567961
129Renovascular hypertension (HP:0100817)1.79646954
130Arachnodactyly (HP:0001166)1.77805908
131Round ear (HP:0100830)1.76038092
132Delayed cranial suture closure (HP:0000270)1.75228326
133Entropion (HP:0000621)1.73116224
134Anterior segment dysgenesis (HP:0007700)1.72049059
135Mesangial abnormality (HP:0001966)1.71751076
136Osteopenia (HP:0000938)1.71704767
137Abnormality of the anterior chamber (HP:0000593)1.71415025
138Thin skin (HP:0000963)1.70917924
139Generalized amyotrophy (HP:0003700)1.70132971
140Flared iliac wings (HP:0002869)1.66998390

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.50573166
2TRIB34.45282335
3PKN23.33239881
4LATS12.89239676
5TIE12.88054012
6TTN2.79608814
7LATS22.78803722
8ERN12.77438696
9PDGFRA2.71164415
10NTRK12.54185572
11SIK12.48159147
12FRK2.38350208
13WNK41.98365967
14STK38L1.95699463
15ADRBK21.81609751
16EPHB21.74012004
17MAP2K31.72816677
18MAP3K31.72643756
19PAK21.72466037
20PAK41.71346848
21KIT1.68966461
22RIPK11.65233848
23MAP3K101.58081483
24PTK21.51483510
25FLT31.50250891
26ADRBK11.49242898
27EIF2AK11.47861408
28PIM21.45462936
29PTK61.41102883
30CDK81.36213534
31EPHA21.35681426
32MET1.35155900
33STK31.33782135
34TGFBR11.29495494
35STK381.26769188
36MTOR1.26131124
37AKT31.25845712
38RPS6KA41.25659357
39BMX1.25423497
40LRRK21.24088422
41EEF2K1.23158611
42PRKD31.18574721
43CDK121.15947059
44IRAK31.15321404
45FGFR11.14445337
46MAP4K21.10053671
47NME21.09988764
48EPHA31.04564187
49TESK11.04042015
50BMPR1B1.03462658
51TGFBR21.02658252
52RPS6KA21.01492028
53PASK1.00938849
54FER0.98933831
55PAK30.96877246
56ILK0.96335771
57CDK70.92193802
58BCKDK0.90558130
59TLK10.87127138
60PRKG20.85499259
61MAP3K60.84735523
62GRK10.83896403
63WEE10.83338295
64NEK10.83175494
65MAPK110.82337865
66TRPM70.81875809
67ERBB40.81065034
68RPS6KB20.79908599
69SCYL20.79348926
70CLK10.77708764
71MOS0.77090812
72WNK10.76062558
73INSRR0.75069601
74ROCK10.73289603
75CDK60.73080758
76PAK60.71675667
77MAP3K80.71354938
78PNCK0.69796519
79ICK0.68663891
80LIMK10.67402278
81KDR0.65550193
82DMPK0.65239699
83DYRK1B0.64163339
84PDGFRB0.63903925
85JAK30.63882882
86NEK90.63864721
87MAP3K70.62929622
88RPS6KA60.60843465
89PIK3CG0.60637450
90TESK20.60322945
91FGFR40.57448434
92PTK2B0.55868704
93CHEK20.55254573
94MAP3K110.54273577
95NEK20.53594147
96PAK10.53419401
97CDK40.52064592
98ABL20.50421077
99STK240.49508644
100MAPK70.49082834
101BUB10.48599066
102MAPKAPK30.48229520
103PRKD20.48109993
104GSK3A0.47655187
105STK100.47512302
106CAMK1D0.46927417
107DAPK30.45809062
108PLK20.44849825
109MAP2K10.44227788
110BRSK20.43232351
111AURKB0.41884793
112TAOK20.41608951
113MYLK0.40707794
114RPS6KL10.40179530
115RPS6KC10.40179530
116RET0.39243271
117PRKCE0.38300607
118TAOK10.37748788
119ZAK0.37693076
120EIF2AK20.37668715
121EPHB10.37463985
122MELK0.37228004
123CDC42BPA0.36946911
124LMTK20.36940594
125SRC0.36679083
126TTK0.36622707
127MKNK10.36066106
128MAPK10.36064789
129INSR0.35894115
130NUAK10.35842197
131CDC70.35076363
132PLK10.34430749
133MAPKAPK50.33416452
134CAMK1G0.32767833
135PRKD10.32025698
136ROCK20.31503602
137PLK30.31329313
138TYRO30.30760660
139PIK3CA0.30680628
140PRKCI0.28549779
141MAPK150.27847579

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.83750145
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.43464150
3Protein digestion and absorption_Homo sapiens_hsa049743.21028559
4Focal adhesion_Homo sapiens_hsa045102.82173265
5Other glycan degradation_Homo sapiens_hsa005112.48134195
6One carbon pool by folate_Homo sapiens_hsa006702.28299835
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.20174042
8Bladder cancer_Homo sapiens_hsa052192.07607883
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.06702151
10Basal cell carcinoma_Homo sapiens_hsa052171.94384903
11Proteoglycans in cancer_Homo sapiens_hsa052051.91288864
12Small cell lung cancer_Homo sapiens_hsa052221.87362906
13TGF-beta signaling pathway_Homo sapiens_hsa043501.86842259
14Hippo signaling pathway_Homo sapiens_hsa043901.77203999
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66548110
16Adherens junction_Homo sapiens_hsa045201.63407055
17Amoebiasis_Homo sapiens_hsa051461.63304237
18PI3K-Akt signaling pathway_Homo sapiens_hsa041511.62813796
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61621215
20Hedgehog signaling pathway_Homo sapiens_hsa043401.56150241
21p53 signaling pathway_Homo sapiens_hsa041151.49986337
22MicroRNAs in cancer_Homo sapiens_hsa052061.47483157
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46735262
24Selenocompound metabolism_Homo sapiens_hsa004501.44036090
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42301767
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41603103
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.40271098
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39906264
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38774049
30Lysosome_Homo sapiens_hsa041421.34783299
31Lysine degradation_Homo sapiens_hsa003101.32673509
32N-Glycan biosynthesis_Homo sapiens_hsa005101.30708135
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29574752
34Dilated cardiomyopathy_Homo sapiens_hsa054141.25419257
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25413997
36Malaria_Homo sapiens_hsa051441.23667210
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21286225
38RNA transport_Homo sapiens_hsa030131.18488831
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17780800
40Chronic myeloid leukemia_Homo sapiens_hsa052201.17264741
41Sulfur metabolism_Homo sapiens_hsa009201.10763365
42Cell cycle_Homo sapiens_hsa041101.10120974
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.05191005
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04638262
45Biosynthesis of amino acids_Homo sapiens_hsa012301.03103998
46Complement and coagulation cascades_Homo sapiens_hsa046100.98950310
47Folate biosynthesis_Homo sapiens_hsa007900.97963616
48Sulfur relay system_Homo sapiens_hsa041220.94605441
49Galactose metabolism_Homo sapiens_hsa000520.93816004
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93502183
51HTLV-I infection_Homo sapiens_hsa051660.85726706
52Axon guidance_Homo sapiens_hsa043600.84438125
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84038852
54DNA replication_Homo sapiens_hsa030300.83343487
55Arginine and proline metabolism_Homo sapiens_hsa003300.81638899
56Pathways in cancer_Homo sapiens_hsa052000.81296341
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80586147
58Nucleotide excision repair_Homo sapiens_hsa034200.78851913
59Prostate cancer_Homo sapiens_hsa052150.78476050
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78199250
61Melanoma_Homo sapiens_hsa052180.75987818
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74846679
63Wnt signaling pathway_Homo sapiens_hsa043100.74128794
64Thyroid cancer_Homo sapiens_hsa052160.73059277
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72147474
66Viral carcinogenesis_Homo sapiens_hsa052030.71620625
67Carbon metabolism_Homo sapiens_hsa012000.70567096
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70449257
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69678186
70Starch and sucrose metabolism_Homo sapiens_hsa005000.69433930
71Notch signaling pathway_Homo sapiens_hsa043300.66499315
72Tight junction_Homo sapiens_hsa045300.66230677
73Steroid biosynthesis_Homo sapiens_hsa001000.65443896
74Shigellosis_Homo sapiens_hsa051310.65154219
75Viral myocarditis_Homo sapiens_hsa054160.64322312
76Sphingolipid metabolism_Homo sapiens_hsa006000.63357807
77Protein export_Homo sapiens_hsa030600.61206713
78HIF-1 signaling pathway_Homo sapiens_hsa040660.60478492
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59544540
80Insulin resistance_Homo sapiens_hsa049310.58633841
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58128646
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55649276
83Base excision repair_Homo sapiens_hsa034100.55493397
84mTOR signaling pathway_Homo sapiens_hsa041500.54409589
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54272124
86ABC transporters_Homo sapiens_hsa020100.53406673
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.53175381
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52770588
89Pancreatic cancer_Homo sapiens_hsa052120.52351649
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.51125719
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50880880
92Ribosome_Homo sapiens_hsa030100.50860191
93RNA polymerase_Homo sapiens_hsa030200.50471277
94AMPK signaling pathway_Homo sapiens_hsa041520.47965735
95Thyroid hormone synthesis_Homo sapiens_hsa049180.47688038
96Mismatch repair_Homo sapiens_hsa034300.47570408
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.47141368
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47139345
99TNF signaling pathway_Homo sapiens_hsa046680.47138501
100Spliceosome_Homo sapiens_hsa030400.46796497
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46262676
102Fatty acid degradation_Homo sapiens_hsa000710.45623177
103Pyrimidine metabolism_Homo sapiens_hsa002400.45535590
104Renin-angiotensin system_Homo sapiens_hsa046140.44940378
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.43496934
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.43110975
107Tryptophan metabolism_Homo sapiens_hsa003800.42949422
108Nitrogen metabolism_Homo sapiens_hsa009100.42618024
109Platelet activation_Homo sapiens_hsa046110.41509676
110Rap1 signaling pathway_Homo sapiens_hsa040150.40669648
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40640097
112Prion diseases_Homo sapiens_hsa050200.40618734
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.40315250
114Ras signaling pathway_Homo sapiens_hsa040140.40224178
115Colorectal cancer_Homo sapiens_hsa052100.40085923
116Apoptosis_Homo sapiens_hsa042100.39903544
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39842876
118Toxoplasmosis_Homo sapiens_hsa051450.39694782
119Fatty acid metabolism_Homo sapiens_hsa012120.39098080
120Fanconi anemia pathway_Homo sapiens_hsa034600.38943572
121Vibrio cholerae infection_Homo sapiens_hsa051100.38792358
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38699487
123PPAR signaling pathway_Homo sapiens_hsa033200.37577385
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.36885505
125Pentose phosphate pathway_Homo sapiens_hsa000300.36562569
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.35647226
127Melanogenesis_Homo sapiens_hsa049160.34372122
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.34345308
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34300844
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34291713
131Glutathione metabolism_Homo sapiens_hsa004800.33981469
132Glycerolipid metabolism_Homo sapiens_hsa005610.30520963
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26642768
134Ether lipid metabolism_Homo sapiens_hsa005650.24005951
135MAPK signaling pathway_Homo sapiens_hsa040100.23852800
136Butanoate metabolism_Homo sapiens_hsa006500.21695589
137Metabolic pathways_Homo sapiens_hsa011000.18905251
138Basal transcription factors_Homo sapiens_hsa030220.16551703
139Phototransduction_Homo sapiens_hsa047440.14981010
140Homologous recombination_Homo sapiens_hsa034400.14723917

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