P3H2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)9.46025457
2glomerulus development (GO:0032835)5.89788455
3keratan sulfate catabolic process (GO:0042340)5.83643721
4chondrocyte development (GO:0002063)5.44537391
5cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.34025921
6endodermal cell differentiation (GO:0035987)4.90595149
7regulation of transforming growth factor beta2 production (GO:0032909)4.64452410
8mesodermal cell differentiation (GO:0048333)4.55635633
9cell aggregation (GO:0098743)4.51713271
10cartilage condensation (GO:0001502)4.51713271
11regulation of cardioblast differentiation (GO:0051890)4.36308652
12sequestering of extracellular ligand from receptor (GO:0035581)4.35663060
13anterior/posterior axis specification, embryo (GO:0008595)4.28240736
14collagen fibril organization (GO:0030199)4.19169250
15negative regulation of activin receptor signaling pathway (GO:0032926)4.06622428
16notochord development (GO:0030903)4.03539390
17cell-substrate junction assembly (GO:0007044)4.01756135
18embryonic foregut morphogenesis (GO:0048617)3.95799512
19negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.94223277
20polarized epithelial cell differentiation (GO:0030859)3.92311157
21cell migration involved in gastrulation (GO:0042074)3.88404388
22regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.81075102
23epithelial cell differentiation involved in kidney development (GO:0035850)3.77156768
24excretion (GO:0007588)3.76963714
25regulation of extracellular matrix disassembly (GO:0010715)3.76826372
26establishment of apical/basal cell polarity (GO:0035089)3.73589674
27positive regulation of protein kinase C signaling (GO:0090037)3.59053368
28negative regulation of keratinocyte proliferation (GO:0010839)3.58702307
29surfactant homeostasis (GO:0043129)3.58450468
30planar cell polarity pathway involved in neural tube closure (GO:0090179)3.54170318
31G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.53743364
32endothelial cell morphogenesis (GO:0001886)3.50293682
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.49162122
34negative regulation of chondrocyte differentiation (GO:0032331)3.48972273
35bundle of His cell to Purkinje myocyte communication (GO:0086069)3.46871914
36regulation of mesoderm development (GO:2000380)3.46687170
37skin morphogenesis (GO:0043589)3.46115097
38dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.45349450
39epithelial cell-cell adhesion (GO:0090136)3.42218224
40positive regulation of p38MAPK cascade (GO:1900745)3.42198004
41renal filtration (GO:0097205)3.40624283
42regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.38849848
43vitamin D metabolic process (GO:0042359)3.35687916
44positive regulation of osteoblast proliferation (GO:0033690)3.35064641
45negative regulation of homotypic cell-cell adhesion (GO:0034111)3.34695823
46embryonic skeletal joint morphogenesis (GO:0060272)3.34601489
47pericardium development (GO:0060039)3.34550431
48regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.31929478
49growth hormone receptor signaling pathway (GO:0060396)3.27459845
50collagen catabolic process (GO:0030574)3.26939505
51regulation of cell proliferation involved in kidney development (GO:1901722)3.26587191
52cartilage development (GO:0051216)3.26525450
53gap junction assembly (GO:0016264)3.25361919
54regulation of apoptotic process involved in morphogenesis (GO:1902337)3.24762308
55negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.24117376
56endochondral ossification (GO:0001958)3.22998031
57replacement ossification (GO:0036075)3.22998031
58multicellular organismal catabolic process (GO:0044243)3.22176839
59aminoglycoside antibiotic metabolic process (GO:0030647)3.21481996
60negative regulation of axon extension involved in axon guidance (GO:0048843)3.21474874
61substrate-dependent cell migration (GO:0006929)3.20477260
62lateral sprouting from an epithelium (GO:0060601)3.19457678
63proteoglycan metabolic process (GO:0006029)3.16838174
64establishment or maintenance of monopolar cell polarity (GO:0061339)3.15779007
65establishment of monopolar cell polarity (GO:0061162)3.15779007
66heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.13067627
67regulation of glucocorticoid metabolic process (GO:0031943)3.12830753
68limb bud formation (GO:0060174)3.12479879
69renal absorption (GO:0070293)3.11743590
70chondrocyte differentiation (GO:0002062)3.11685333
71multicellular organismal macromolecule metabolic process (GO:0044259)3.11404709
72collagen metabolic process (GO:0032963)3.11387930
73COPI coating of Golgi vesicle (GO:0048205)3.08425806
74Golgi transport vesicle coating (GO:0048200)3.08425806
75basement membrane organization (GO:0071711)3.06959610
76paraxial mesoderm development (GO:0048339)3.03973640
77regulation of hippo signaling (GO:0035330)3.03904046
78endocardial cushion development (GO:0003197)3.02397053
79glucose 6-phosphate metabolic process (GO:0051156)3.01862850
80embryonic viscerocranium morphogenesis (GO:0048703)3.00417779
81hypotonic response (GO:0006971)2.99536908
82positive regulation of astrocyte differentiation (GO:0048711)2.99177621
83negative regulation of cell fate specification (GO:0009996)2.98498938
84multicellular organismal metabolic process (GO:0044236)2.95886500
85cell proliferation involved in kidney development (GO:0072111)2.94438890
86ventricular cardiac muscle cell development (GO:0055015)2.92990988
87positive regulation of cartilage development (GO:0061036)2.92286097
88glomerular filtration (GO:0003094)2.92242214
89hemidesmosome assembly (GO:0031581)2.92149572
90midgut development (GO:0007494)2.92057801
91response to BMP (GO:0071772)2.91330305
92cellular response to BMP stimulus (GO:0071773)2.91330305
93Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.90845224
94chemical homeostasis within a tissue (GO:0048875)2.90819023
95lung morphogenesis (GO:0060425)2.90748697
96negative regulation of axon guidance (GO:1902668)2.90109462
97bone trabecula formation (GO:0060346)2.89011527
98chondrocyte proliferation (GO:0035988)2.88978383
99positive regulation of male gonad development (GO:2000020)2.86307993
100retina vasculature morphogenesis in camera-type eye (GO:0061299)2.85123780
101establishment of planar polarity (GO:0001736)2.84190021
102establishment of tissue polarity (GO:0007164)2.84190021
103cellular response to growth hormone stimulus (GO:0071378)2.82456800
104wound healing, spreading of epidermal cells (GO:0035313)2.82234792
105regulation of axon extension involved in axon guidance (GO:0048841)2.81762386
106regulation of transforming growth factor beta1 production (GO:0032908)2.81614605
107cellular response to vitamin D (GO:0071305)2.81139349
108regulation of establishment of planar polarity (GO:0090175)2.80060587
109regulation of integrin-mediated signaling pathway (GO:2001044)2.78966830
110desmosome organization (GO:0002934)2.78649406
111primitive streak formation (GO:0090009)2.77983445
112cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.77771710
113lung vasculature development (GO:0060426)2.77295050
114hippo signaling (GO:0035329)2.76904403
115protein heterotrimerization (GO:0070208)2.76160776
116regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.75753851
117regulation of alkaline phosphatase activity (GO:0010692)2.74880779
118positive regulation of chondrocyte differentiation (GO:0032332)2.74186062
119metanephric epithelium development (GO:0072207)2.71952425
120regulation of glomerulus development (GO:0090192)2.71408363
121negative regulation of hormone biosynthetic process (GO:0032353)2.68561260
122adherens junction assembly (GO:0034333)2.68421954
123sphingomyelin metabolic process (GO:0006684)2.67463182
124response to vitamin D (GO:0033280)2.66875255
125extracellular matrix assembly (GO:0085029)2.65990772
126cell adhesion mediated by integrin (GO:0033627)2.65979792
127renal system development (GO:0072001)2.65213638
128anterior/posterior axis specification (GO:0009948)2.64877522
129non-canonical Wnt signaling pathway (GO:0035567)2.64605587
130lymph vessel development (GO:0001945)2.64008600
131negative regulation of platelet activation (GO:0010544)2.63183066
132mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.62139293
133regulation of hair follicle development (GO:0051797)2.61770792
134cellular response to vitamin (GO:0071295)2.60987756
135cell-substrate adherens junction assembly (GO:0007045)2.60172990
136focal adhesion assembly (GO:0048041)2.60172990
137skeletal system development (GO:0001501)2.60050005
138regulation of male gonad development (GO:2000018)2.60024231
139neuron projection extension involved in neuron projection guidance (GO:1902284)2.59807617
140axon extension involved in axon guidance (GO:0048846)2.59807617
141positive regulation of cardiac muscle cell proliferation (GO:0060045)2.58730206
142extracellular matrix disassembly (GO:0022617)2.57541770
143peptidyl-proline hydroxylation (GO:0019511)2.56664363
144regulation of activin receptor signaling pathway (GO:0032925)2.56642542
145organic cation transport (GO:0015695)2.56184252
146regulation of axon guidance (GO:1902667)2.55193495
147positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.54512634
148positive regulation of extracellular matrix organization (GO:1903055)2.54487949
149activation of Rac GTPase activity (GO:0032863)2.53857371
150cGMP-mediated signaling (GO:0019934)2.52881651
151mesonephric tubule development (GO:0072164)2.52330383
152iron ion import (GO:0097286)2.52307700
153maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.52238640
154neural crest cell development (GO:0014032)2.52045969
155drug transmembrane transport (GO:0006855)2.51336989
156protein retention in ER lumen (GO:0006621)2.51232957
157lymphangiogenesis (GO:0001946)2.50624326
158extracellular matrix organization (GO:0030198)2.49761063
159chondroitin sulfate biosynthetic process (GO:0030206)2.49597285
160regulation of mesenchymal cell apoptotic process (GO:2001053)2.49495350
161mesonephric epithelium development (GO:0072163)2.49333084
162extracellular structure organization (GO:0043062)2.48556101
163mesenchyme morphogenesis (GO:0072132)2.48275774
164cell migration involved in sprouting angiogenesis (GO:0002042)2.45250604
165response to magnesium ion (GO:0032026)2.45187014
166ureteric bud development (GO:0001657)2.44532097
167heart valve morphogenesis (GO:0003179)2.43650151
168branching involved in salivary gland morphogenesis (GO:0060445)2.42504245
169response to mercury ion (GO:0046689)2.42063849
170negative regulation of bone resorption (GO:0045779)2.40997146
171SMAD protein signal transduction (GO:0060395)2.40964294
172atrioventricular valve morphogenesis (GO:0003181)2.40456523
173substrate adhesion-dependent cell spreading (GO:0034446)2.40397699
174glomerular visceral epithelial cell development (GO:0072015)11.1480420
175glomerular epithelial cell development (GO:0072310)10.2544958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.61179918
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.54379625
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.64554457
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.59805497
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.08137333
6WT1_19549856_ChIP-ChIP_CCG9911_Human3.04888317
7GATA1_22025678_ChIP-Seq_K562_Human2.81820183
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75190446
9AR_21909140_ChIP-Seq_LNCAP_Human2.60155820
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.47970848
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31512451
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.26686059
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.17018962
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.03791072
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.03315379
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00334695
17EP300_21415370_ChIP-Seq_HL-1_Mouse1.96737096
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96682093
19TCF3_18692474_ChIP-Seq_MEFs_Mouse1.92043542
20CDX2_20551321_ChIP-Seq_CACO-2_Human1.91651762
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.90469855
22CJUN_26792858_Chip-Seq_BT549_Human1.89007924
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85079157
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84664435
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.83760730
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80705893
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77630941
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.76588905
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71656200
30EOMES_21245162_ChIP-Seq_HESCs_Human1.69892809
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.65764632
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.65764632
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.65764632
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63395896
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62393353
36CLOCK_20551151_ChIP-Seq_293T_Human1.61738597
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57141280
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56293110
39VDR_24787735_ChIP-Seq_THP-1_Human1.55894694
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.55525357
41UBF1/2_26484160_Chip-Seq_HMECs_Human1.53670567
42SOX2_20726797_ChIP-Seq_SW620_Human1.53258213
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50791896
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50251891
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49959069
46EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.49568718
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48590583
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47547819
49SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46089791
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45124481
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45124481
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43482928
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43304798
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41649750
55AR_21572438_ChIP-Seq_LNCaP_Human1.39532742
56TP53_18474530_ChIP-ChIP_U2OS_Human1.37746549
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37241356
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36337842
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.35527958
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34891289
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34615270
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.34566056
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.34149470
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33239345
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.32696780
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.32047758
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32043769
68E2F7_22180533_ChIP-Seq_HELA_Human1.32035117
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30017115
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29797676
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.27614028
72TBX20_22080862_ChIP-Seq_HEART_Mouse1.27614028
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27347609
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.27215081
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.26974193
76MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.25669900
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24900769
78TCF3_18692474_ChIP-Seq_MESCs_Mouse1.24511624
79ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23471126
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22212515
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.22141034
82RXR_22108803_ChIP-Seq_LS180_Human1.22085819
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.21546816
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21024406
85SMAD3_21741376_ChIP-Seq_HESCs_Human1.20778193
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20516013
87GBX2_23144817_ChIP-Seq_PC3_Human1.20501701
88JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19427354
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19138451
90FOXM1_23109430_ChIP-Seq_U2OS_Human1.17466310
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16134804
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15536770
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14622058
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11874064
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11502752
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10127954
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09438058
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09438058
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09327723
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09327723
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08671425
102AHR_22903824_ChIP-Seq_MCF-7_Human1.04228914
103ISL1_27105846_Chip-Seq_CPCs_Mouse1.03991721
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.03723981
105TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03646553
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03430075
107TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01923610
108ZNF263_19887448_ChIP-Seq_K562_Human1.01636894
109TP53_20018659_ChIP-ChIP_R1E_Mouse1.01455957
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01343507
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.00563708
112RNF2_27304074_Chip-Seq_ESCs_Mouse1.00426729
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99960853
114NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98958253
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98922809
116NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98499237
117TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96999621
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96374211
119TCF4_22108803_ChIP-Seq_LS180_Human0.96295674
120JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95542716
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94270441
122BRD4_25478319_ChIP-Seq_HGPS_Human0.94015199
123TP63_23658742_ChIP-Seq_EP156T_Human0.93813571
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93737345
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93627998
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93560734
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.93414488
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93221695
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92560199
130POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92086765
131TP53_22127205_ChIP-Seq_IMR90_Human0.91684929
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91401475
133SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91048238
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90871112
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90833941
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90325063
137ATF3_27146783_Chip-Seq_COLON_Human0.89747326
138STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89649490
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.87991547
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86449768
141SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86029219
142TP53_16413492_ChIP-PET_HCT116_Human0.85980819
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82981922
144SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82347673
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82034936
146TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81759187
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79840972
148RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78971555
149TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78245718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane3.89251349
2MP0005503_abnormal_tendon_morphology3.68620472
3MP0002933_joint_inflammation3.13258134
4MP0002282_abnormal_trachea_morphology2.91069371
5MP0004084_abnormal_cardiac_muscle2.84483406
6MP0000579_abnormal_nail_morphology2.81691341
7MP0003705_abnormal_hypodermis_morpholog2.74900496
8MP0003941_abnormal_skin_development2.70800179
9MP0009250_abnormal_appendicular_skeleto2.63598407
10MP0000163_abnormal_cartilage_morphology2.59897674
11MP0003890_abnormal_embryonic-extraembry2.56178978
12MP0005058_abnormal_lysosome_morphology2.45236567
13MP0003950_abnormal_plasma_membrane2.35200247
14MP0009384_cardiac_valve_regurgitation2.33202651
15MP0002115_abnormal_skeleton_extremities2.30039507
16MP0004134_abnormal_chest_morphology2.29036126
17MP0000762_abnormal_tongue_morphology2.27697077
18MP0006054_spinal_hemorrhage2.27370612
19MP0002896_abnormal_bone_mineralization2.20391509
20MP0003566_abnormal_cell_adhesion2.11083474
21MP0009053_abnormal_anal_canal2.02502459
22MP0002136_abnormal_kidney_physiology1.96520340
23MP0010368_abnormal_lymphatic_system1.95510512
24MP0005623_abnormal_meninges_morphology1.94750033
25MP0002113_abnormal_skeleton_development1.89729330
26MP0002254_reproductive_system_inflammat1.86381580
27MP0003646_muscle_fatigue1.83525877
28MP0004043_abnormal_pH_regulation1.82554606
29MP0004036_abnormal_muscle_relaxation1.80282310
30MP0009643_abnormal_urine_homeostasis1.77044561
31MP0002060_abnormal_skin_morphology1.76016618
32MP0001756_abnormal_urination1.73618053
33MP0005508_abnormal_skeleton_morphology1.72150164
34MP0003279_aneurysm1.72016099
35MP0003119_abnormal_digestive_system1.70655707
36MP0001270_distended_abdomen1.67342964
37MP0001299_abnormal_eye_distance/1.67121851
38MP0002109_abnormal_limb_morphology1.66488909
39MP0003195_calcinosis1.65688838
40MP0003942_abnormal_urinary_system1.65202359
41MP0000462_abnormal_digestive_system1.64318605
42MP0005257_abnormal_intraocular_pressure1.63624322
43MP0005451_abnormal_body_composition1.63199340
44MP0000749_muscle_degeneration1.61436590
45MP0004019_abnormal_vitamin_homeostasis1.61222125
46MP0000230_abnormal_systemic_arterial1.59191460
47MP0003283_abnormal_digestive_organ1.58663692
48MP0000534_abnormal_ureter_morphology1.54784506
49MP0000751_myopathy1.53119275
50MP0004484_altered_response_of1.52184351
51MP0005332_abnormal_amino_acid1.51650405
52MP0001879_abnormal_lymphatic_vessel1.50293328
53MP0003795_abnormal_bone_structure1.50161124
54MP0005390_skeleton_phenotype1.47155607
55MP0005197_abnormal_uvea_morphology1.44374590
56MP0001849_ear_inflammation1.41163959
57MP0002998_abnormal_bone_remodeling1.40237372
58MP0010352_gastrointestinal_tract_polyps1.39015998
59MP0000383_abnormal_hair_follicle1.36030870
60MP0001533_abnormal_skeleton_physiology1.35954998
61MP0000049_abnormal_middle_ear1.35088255
62MP0004133_heterotaxia1.34089683
63MP0008775_abnormal_heart_ventricle1.33083924
64MP0001958_emphysema1.31791493
65MP0002089_abnormal_postnatal_growth/wei1.31677414
66MP0002234_abnormal_pharynx_morphology1.30678623
67MP0002249_abnormal_larynx_morphology1.30341917
68MP0005670_abnormal_white_adipose1.30033475
69MP0009780_abnormal_chondrocyte_physiolo1.29198736
70MP0001765_abnormal_ion_homeostasis1.28185712
71MP0002972_abnormal_cardiac_muscle1.27774896
72MP0010030_abnormal_orbit_morphology1.24122565
73MP0002135_abnormal_kidney_morphology1.23539973
74MP0002116_abnormal_craniofacial_bone1.22785698
75MP0008438_abnormal_cutaneous_collagen1.22649720
76MP0000566_synostosis1.20977211
77MP0000538_abnormal_urinary_bladder1.20972801
78MP0002084_abnormal_developmental_patter1.20533310
79MP0000467_abnormal_esophagus_morphology1.18758939
80MP0002138_abnormal_hepatobiliary_system1.17308535
81MP0005275_abnormal_skin_tensile1.15860985
82MP0000013_abnormal_adipose_tissue1.14652893
83MP0008932_abnormal_embryonic_tissue1.14587510
84MP0002108_abnormal_muscle_morphology1.13694146
85MP0004233_abnormal_muscle_weight1.12968166
86MP0000432_abnormal_head_morphology1.11466597
87MP0000678_abnormal_parathyroid_gland1.11316173
88MP0003122_maternal_imprinting1.09829151
89MP0001661_extended_life_span1.09568733
90MP0002295_abnormal_pulmonary_circulatio1.08260572
91MP0005394_taste/olfaction_phenotype1.07521137
92MP0005499_abnormal_olfactory_system1.07521137
93MP0001915_intracranial_hemorrhage1.07308374
94MP0004510_myositis1.06019279
95MP0004858_abnormal_nervous_system1.05475978
96MP0002877_abnormal_melanocyte_morpholog1.04824550
97MP0003937_abnormal_limbs/digits/tail_de1.03653945
98MP0005023_abnormal_wound_healing1.01574105
99MP0003828_pulmonary_edema1.00701498
100MP0010234_abnormal_vibrissa_follicle1.00261046
101MP0003385_abnormal_body_wall0.99378070
102MP0000516_abnormal_urinary_system0.97292853
103MP0005367_renal/urinary_system_phenotyp0.97292853
104MP0006138_congestive_heart_failure0.96587915
105MP0001542_abnormal_bone_strength0.95375125
106MP0003755_abnormal_palate_morphology0.94830449
107MP0002085_abnormal_embryonic_tissue0.94397731
108MP0000343_altered_response_to0.94386994
109MP0005380_embryogenesis_phenotype0.94008914
110MP0001672_abnormal_embryogenesis/_devel0.94008914
111MP0001286_abnormal_eye_development0.93374632
112MP0000767_abnormal_smooth_muscle0.93030591
113MP0002177_abnormal_outer_ear0.92872488
114MP0002098_abnormal_vibrissa_morphology0.92796691
115MP0005193_abnormal_anterior_eye0.90246998
116MP0003091_abnormal_cell_migration0.90235214
117MP0003315_abnormal_perineum_morphology0.89886466
118MP0002925_abnormal_cardiovascular_devel0.89415553
119MP0000537_abnormal_urethra_morphology0.89338170
120MP0005620_abnormal_muscle_contractility0.89061155
121MP0010678_abnormal_skin_adnexa0.89042578
122MP0008961_abnormal_basal_metabolism0.86797248
123MP0005165_increased_susceptibility_to0.86457669
124MP0001216_abnormal_epidermal_layer0.86308247
125MP0002697_abnormal_eye_size0.85090891
126MP0002233_abnormal_nose_morphology0.85037041
127MP0002796_impaired_skin_barrier0.84902369
128MP0003984_embryonic_growth_retardation0.84632921
129MP0000733_abnormal_muscle_development0.84053351
130MP0001348_abnormal_lacrimal_gland0.83418975
131MP0004957_abnormal_blastocyst_morpholog0.83214566
132MP0002932_abnormal_joint_morphology0.83199862
133MP0000647_abnormal_sebaceous_gland0.81908495
134MP0002088_abnormal_embryonic_growth/wei0.81338953
135MP0002086_abnormal_extraembryonic_tissu0.80914422
136MP0010771_integument_phenotype0.80585513
137MP0008004_abnormal_stomach_pH0.80538976
138MP0008789_abnormal_olfactory_epithelium0.80039824
139MP0001346_abnormal_lacrimal_gland0.79933924
140MP0001614_abnormal_blood_vessel0.79762059
141MP0003935_abnormal_craniofacial_develop0.79548298
142MP0002163_abnormal_gland_morphology0.79308624
143MP0002111_abnormal_tail_morphology0.79272531
144MP0001784_abnormal_fluid_regulation0.78999403
145MP0004782_abnormal_surfactant_physiolog0.78178487
146MP0001243_abnormal_dermal_layer0.77985228
147MP0003453_abnormal_keratinocyte_physiol0.77232895
148MP0005377_hearing/vestibular/ear_phenot0.76033392
149MP0003878_abnormal_ear_physiology0.76033392
150MP0000627_abnormal_mammary_gland0.75863118
151MP0005501_abnormal_skin_physiology0.75833177
152MP0003936_abnormal_reproductive_system0.74360068
153MP0005330_cardiomyopathy0.74143342
154MP0000428_abnormal_craniofacial_morphol0.72133457
155MP0005076_abnormal_cell_differentiation0.71813697

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)7.47207603
2Premature rupture of membranes (HP:0001788)6.73992826
3Irregular epiphyses (HP:0010582)6.12506264
4Abnormal tarsal ossification (HP:0008369)5.96087734
5Delayed epiphyseal ossification (HP:0002663)5.90954401
6Atrophic scars (HP:0001075)5.69647525
7Vitreoretinal degeneration (HP:0000655)5.60040408
8Metaphyseal cupping (HP:0003021)5.24224048
9Small epiphyses (HP:0010585)4.94592083
10Metaphyseal dysplasia (HP:0100255)4.75506086
11Hypoplastic ischia (HP:0003175)4.68696414
12Abnormal foot bone ossification (HP:0010675)4.39720923
13Cupped ribs (HP:0000887)4.38464372
14Flat capital femoral epiphysis (HP:0003370)4.34099150
15Abnormality of the ischium (HP:0003174)4.14664687
16Flat acetabular roof (HP:0003180)4.09850922
17Protrusio acetabuli (HP:0003179)3.96645579
18Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.95107547
19Aortic dissection (HP:0002647)3.91309607
20Genu varum (HP:0002970)3.89568748
21Abnormality of the fetal cardiovascular system (HP:0010948)3.85369943
22Abnormal umbilical cord blood vessels (HP:0011403)3.85369943
23Single umbilical artery (HP:0001195)3.85369943
24Fragile skin (HP:0001030)3.78735681
25Neonatal short-limb short stature (HP:0008921)3.66000524
26Mesangial abnormality (HP:0001966)3.52266140
27Arterial tortuosity (HP:0005116)3.48080879
28Abnormality of carpal bone ossification (HP:0006257)3.47136207
29Fragile nails (HP:0001808)3.46787639
30Soft skin (HP:0000977)3.45912395
31Focal segmental glomerulosclerosis (HP:0000097)3.42349491
32Metaphyseal irregularity (HP:0003025)3.40019306
33Onycholysis (HP:0001806)3.32398204
34Vascular tortuosity (HP:0004948)3.31677111
35Abnormality of femoral epiphyses (HP:0006499)3.22347129
36Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.22347129
37Milia (HP:0001056)3.22165810
38Hip contracture (HP:0003273)3.21147743
39Flattened epiphyses (HP:0003071)3.20522212
40Increased circulating renin level (HP:0000848)3.20241102
41Limited hip movement (HP:0008800)3.19399747
42Mild short stature (HP:0003502)3.12354299
43Short femoral neck (HP:0100864)3.09749976
44Ovoid vertebral bodies (HP:0003300)3.09678863
45Metabolic alkalosis (HP:0200114)3.07211842
46Hypokalemic alkalosis (HP:0001949)3.05507931
47Abnormality of the umbilical cord (HP:0010881)3.04492735
48Abnormality of the vertebral endplates (HP:0005106)3.02273560
49Abnormality of the epiphysis of the femoral head (HP:0010574)2.95346723
50Osteoarthritis (HP:0002758)2.94442640
51Abnormality of dentin (HP:0010299)2.91125949
52Enlarged epiphyses (HP:0010580)2.87535057
53Irregular vertebral endplates (HP:0003301)2.85565113
54Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.84777139
55Cervical subluxation (HP:0003308)2.82948355
56Bladder diverticulum (HP:0000015)2.81143684
57Abnormal hand bone ossification (HP:0010660)2.80159459
58Protuberant abdomen (HP:0001538)2.80039634
59Glomerulosclerosis (HP:0000096)2.79510666
60Hypomagnesemia (HP:0002917)2.77369838
61Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.77189732
62Absent epiphyses (HP:0010577)2.77189732
63Arthropathy (HP:0003040)2.75140949
64Abnormal vertebral ossification (HP:0100569)2.74770787
65Polyuria (HP:0000103)2.68437730
66Pterygium (HP:0001059)2.68103848
67Abnormality of the femoral head (HP:0003368)2.67597342
68Abnormal ossification of hand bones (HP:0005921)2.65873544
69Ankle contracture (HP:0006466)2.63399378
70Selective tooth agenesis (HP:0001592)2.61240938
71Ulnar bowing (HP:0003031)2.59206856
72Follicular hyperkeratosis (HP:0007502)2.58237618
73Platyspondyly (HP:0000926)2.57122762
74Natal tooth (HP:0000695)2.56614109
75Beaking of vertebral bodies (HP:0004568)2.54097779
76Waddling gait (HP:0002515)2.53952556
77Barrel-shaped chest (HP:0001552)2.53822077
78Abnormality of magnesium homeostasis (HP:0004921)2.53292121
79Abnormal albumin level (HP:0012116)2.51785466
80Hypoalbuminemia (HP:0003073)2.51785466
81Blue sclerae (HP:0000592)2.50447831
82Coxa vara (HP:0002812)2.50061990
83Glomerulonephritis (HP:0000099)2.49392264
84Hyperactive renin-angiotensin system (HP:0000841)2.48346345
85Right ventricular cardiomyopathy (HP:0011663)2.44685051
86Abnormal urine output (HP:0012590)2.43583912
87Exostoses (HP:0100777)2.42784462
88Shallow orbits (HP:0000586)2.40049593
89Abnormal drinking behavior (HP:0030082)2.39500153
90Polydipsia (HP:0001959)2.39500153
91Limited elbow extension (HP:0001377)2.38743510
92Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.38041026
93Tubular atrophy (HP:0000092)2.36780583
94Abnormality of chloride homeostasis (HP:0011422)2.34004204
95Wormian bones (HP:0002645)2.32886748
96Abnormality of renal excretion (HP:0011036)2.32677073
97Abnormality of incisor morphology (HP:0011063)2.32138925
98Hydroxyprolinuria (HP:0003080)2.30289950
99Abnormality of proline metabolism (HP:0010907)2.30289950
100Ankyloglossia (HP:0010296)2.29568550
101Short humerus (HP:0005792)2.28946821
102Hypoplasia of the odontoid process (HP:0003311)2.27878518
103Spinal rigidity (HP:0003306)2.27394380
104Abnormality of the pubic bones (HP:0003172)2.25365391
105Mesomelia (HP:0003027)2.24959198
106Abnormality of the phalanges of the 2nd finger (HP:0009541)2.23300353
107Hydroureter (HP:0000072)2.22834316
108Abnormalities of placenta or umbilical cord (HP:0001194)2.21393663
109Aplasia/hypoplasia of the femur (HP:0005613)2.20081263
110Stillbirth (HP:0003826)2.18906606
111Persistence of primary teeth (HP:0006335)2.18539519
112Plantar hyperkeratosis (HP:0007556)2.17272909
113Hypercalciuria (HP:0002150)2.16832600
114Tetany (HP:0001281)2.16727303
115Flared metaphyses (HP:0003015)2.16707958
116Lumbar hyperlordosis (HP:0002938)2.16678463
117Abnormality of oral frenula (HP:0000190)2.15954031
118Carpal bone hypoplasia (HP:0001498)2.11582072
119Short nail (HP:0001799)2.10824573
120Aplasia/hypoplasia of the humerus (HP:0006507)2.10517798
121Disproportionate short-trunk short stature (HP:0003521)2.10484757
122Mitral valve prolapse (HP:0001634)2.10374193
123Abnormality of the distal phalanges of the toes (HP:0010182)2.09201730
124Joint stiffness (HP:0001387)2.08929513
125Elbow flexion contracture (HP:0002987)2.06533446
126Nephritis (HP:0000123)2.06379385
127Spinal cord compression (HP:0002176)2.04425695
128Genu recurvatum (HP:0002816)2.04147099
129Popliteal pterygium (HP:0009756)2.03286513
130Abnormality of the proximal phalanges of the hand (HP:0009834)2.03102034
131Short hallux (HP:0010109)2.03026553
132Severe short stature (HP:0003510)2.00731196
133Knee flexion contracture (HP:0006380)1.97785527
134Short middle phalanx of finger (HP:0005819)1.96638655
135Aplasia of the musculature (HP:0100854)1.93676109
136Abnormal delivery (HP:0001787)1.93057635
137Myelomeningocele (HP:0002475)1.92445387
138Lymphangioma (HP:0100764)1.91793312
139Patent foramen ovale (HP:0001655)1.90373451
140Abnormality of the odontoid process (HP:0003310)1.89982154
141Abnormal pancreas size (HP:0012094)1.89101961
142Abnormality of renin-angiotensin system (HP:0000847)1.88947185
143Aortic aneurysm (HP:0004942)1.88795477
144Preaxial foot polydactyly (HP:0001841)1.88538870
145Ectopia lentis (HP:0001083)1.87804186
146Osteolytic defects of the hand bones (HP:0009699)1.86854563
147Osteolytic defects of the phalanges of the hand (HP:0009771)1.86854563
148Abnormality of the 2nd finger (HP:0004100)1.83043555
149Thick nail (HP:0001805)1.82810827
150Aplasia/Hypoplasia of the hallux (HP:0008362)1.82209185
151Nail dystrophy (HP:0008404)1.81074950
152Delayed gross motor development (HP:0002194)1.80533165
153Vertebral clefting (HP:0008428)1.80356195
154Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.80044902
155Thin ribs (HP:0000883)1.79075105
156Long palpebral fissure (HP:0000637)1.78425206
157Abnormality of the middle phalanges of the toes (HP:0010183)1.77595971
158Hyperextensible skin (HP:0000974)1.77381824
159Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.77312415
160Coronal craniosynostosis (HP:0004440)1.76005421
161Bowel diverticulosis (HP:0005222)1.74870141
162Dilatation of the ascending aorta (HP:0005111)1.74213645
163Broad metatarsal (HP:0001783)1.73741937
164Back pain (HP:0003418)1.72895580
165Bifid tongue (HP:0010297)1.71618263
166Anal stenosis (HP:0002025)1.71405885
167Deviation of the thumb (HP:0009603)1.70397652
168Peritonitis (HP:0002586)1.69387115
169Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.68797643
170Absent toe (HP:0010760)1.68378571
171Joint laxity (HP:0001388)1.67860636
172Fused cervical vertebrae (HP:0002949)1.67816614
173Short middle phalanx of the 5th finger (HP:0004220)1.67612257
174Abnormality of nail color (HP:0100643)1.66995843
175Advanced eruption of teeth (HP:0006288)1.65266653
176Wide anterior fontanel (HP:0000260)1.64778257
177Bowing of the arm (HP:0006488)1.63627147
178Bowed forearm bones (HP:0003956)1.63627147
179Abnormality of the acetabulum (HP:0003170)1.61266544
180Aplasia/Hypoplasia of the scapulae (HP:0006713)1.60985636
181Hypoplastic scapulae (HP:0000882)1.60985636
182Breech presentation (HP:0001623)1.60443506
183Vertebral compression fractures (HP:0002953)1.60366195
184Renal duplication (HP:0000075)1.58357119
185Long toe (HP:0010511)1.57537220
186Deviation of the hallux (HP:0010051)1.57472087
187Neonatal death (HP:0003811)1.57382916
188Rhizomelia (HP:0008905)1.57029113
189Trismus (HP:0000211)1.56074285
190Arachnodactyly (HP:0001166)1.55264338
191Hallux valgus (HP:0001822)1.55063120
192Hypoplasia of dental enamel (HP:0006297)1.54257899
193Pulmonic stenosis (HP:0001642)1.53983704

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.61533921
2STK38L4.38600497
3TGFBR24.38500094
4OXSR14.01604843
5WNK33.54375060
6ERBB43.31810141
7STK393.09758821
8STK242.89161450
9EPHB22.84750538
10OBSCN2.80157377
11MAP3K32.73344025
12MET2.64888133
13ARAF2.45623171
14DDR22.43980034
15PDGFRA2.43811220
16PBK2.35066382
17LATS22.33432655
18FLT32.28936659
19TTN2.04047836
20LATS12.02179690
21NME11.94520657
22NEK11.81920413
23MYLK1.76862194
24MAP3K91.76067325
25BMPR1B1.70073249
26SIK31.65274689
27MAP3K121.59824832
28TIE11.57612435
29PTK2B1.51995805
30LIMK11.45679168
31MELK1.41983426
32FER1.36973194
33BMX1.36788755
34ROCK21.36440051
35PAK41.33155237
36RIPK11.31759841
37PNCK1.28597188
38EPHB11.26754424
39CSF1R1.26560504
40STK31.23798878
41TRPM71.22887143
42PIK3CA1.22596124
43TTK1.19911431
44PRKG21.18257210
45MST41.17533718
46ROCK11.14826669
47MAP3K81.14341655
48GRK71.14099197
49WEE11.12971723
50TRIM281.12725687
51TGFBR11.11640760
52ERBB31.11275775
53TESK11.10514561
54ZAK1.08568454
55PDK21.08094727
56NUAK11.06772168
57SIK11.03665335
58EPHA30.99626825
59MAP3K130.99514052
60PTK20.98914762
61WNK10.96328813
62BRAF0.96016716
63STK100.94672361
64NTRK10.94038564
65ILK0.90830770
66MST1R0.90047372
67BUB10.89420550
68PIM20.89023681
69PKN20.88980511
70MAPK150.84709973
71NEK60.83736757
72BCR0.82374941
73MAP3K140.81356296
74PLK40.80310684
75DAPK30.77640241
76LMTK20.76994506
77INSRR0.75934492
78GSK3A0.75793356
79MAP3K100.69934222
80CDK80.69442636
81NEK20.69437913
82EIF2AK20.69000947
83TSSK60.68758335
84PLK30.67700466
85PAK20.65977552
86DMPK0.64099982
87IGF1R0.63969578
88BRSK20.63298479
89SGK4940.63200701
90SGK2230.63200701
91MAPK120.62735098
92MAP2K30.61924849
93LRRK20.61224994
94STK380.61094303
95SGK20.55457365
96AKT30.53431993
97NEK90.52934857
98CHUK0.52413176
99MTOR0.50421818
100PAK10.50223922
101MAPK70.50181450
102MAPKAPK30.49770831
103PLK20.48940940
104MAP3K20.48315301
105MOS0.47911501
106JAK10.46721611
107PDGFRB0.45332269
108AURKB0.44581160
109TNIK0.44433555
110TYK20.44374946
111CDC42BPA0.44026773
112RPS6KA20.43968162
113FGFR30.42781823
114EGFR0.42667349
115EPHA20.42518745
116SMG10.41824902
117CLK10.41183856
118INSR0.40810740
119PLK10.40118680
120RAF10.38986530
121CDK90.38925952
122GRK10.38871585
123KSR20.36711378
124CDK70.35998040
125AKT20.35187102
126PRKD20.34388292
127MKNK10.33735715
128SGK30.31823214
129FGFR40.30455469
130KDR0.29405432
131RET0.29070366
132TBK10.28243578
133EIF2AK30.28197791
134FGFR10.27934557
135SGK10.27338733
136PTK60.27082677
137PRKCE0.26257742
138SRC0.23532382
139PRKCD0.22064048
140PRKAA20.21413961
141FGR0.21054019
142IKBKB0.20900760
143MAPKAPK20.20237650
144DYRK1A0.19736102
145MAPK30.18511247
146CAMK1D0.18424160
147PAK30.18222739
148KSR10.16421382
149ERBB20.16051612
150ADRBK10.15292221
151PIK3CG0.15030336
152CAMK1G0.14942234
153MAP2K10.14170721
154NLK0.14045284

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.99672844
2ECM-receptor interaction_Homo sapiens_hsa045124.71864890
3Protein digestion and absorption_Homo sapiens_hsa049744.00795544
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.20332198
5Other glycan degradation_Homo sapiens_hsa005112.96589677
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.56896406
7Focal adhesion_Homo sapiens_hsa045102.38323660
8Renin-angiotensin system_Homo sapiens_hsa046142.35424834
9Steroid biosynthesis_Homo sapiens_hsa001002.00466744
10Arachidonic acid metabolism_Homo sapiens_hsa005901.82097978
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.79424785
12Sphingolipid metabolism_Homo sapiens_hsa006001.66149475
13Small cell lung cancer_Homo sapiens_hsa052221.64156413
14Lysosome_Homo sapiens_hsa041421.63975454
15Selenocompound metabolism_Homo sapiens_hsa004501.59228592
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.57312763
17p53 signaling pathway_Homo sapiens_hsa041151.52124086
18Dilated cardiomyopathy_Homo sapiens_hsa054141.48792469
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47917114
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47883162
21Sulfur metabolism_Homo sapiens_hsa009201.41755872
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.40285968
23Lysine degradation_Homo sapiens_hsa003101.39741252
24Adherens junction_Homo sapiens_hsa045201.39213599
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38070130
26Starch and sucrose metabolism_Homo sapiens_hsa005001.37129661
27Proteasome_Homo sapiens_hsa030501.35166389
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34608034
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33690055
30Amoebiasis_Homo sapiens_hsa051461.33442257
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.32648515
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30999967
33Galactose metabolism_Homo sapiens_hsa000521.29025488
34Vitamin digestion and absorption_Homo sapiens_hsa049771.28434821
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27350330
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25782651
37Malaria_Homo sapiens_hsa051441.24999698
38Hippo signaling pathway_Homo sapiens_hsa043901.21976527
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20445745
40Proteoglycans in cancer_Homo sapiens_hsa052051.14915001
41Thyroid cancer_Homo sapiens_hsa052161.13785797
42Melanoma_Homo sapiens_hsa052181.09053108
43TGF-beta signaling pathway_Homo sapiens_hsa043501.06860333
44Basal cell carcinoma_Homo sapiens_hsa052171.05824570
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04383080
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02896034
47Mineral absorption_Homo sapiens_hsa049781.01844110
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00594796
49Melanogenesis_Homo sapiens_hsa049161.00266321
50Hedgehog signaling pathway_Homo sapiens_hsa043400.97186070
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94595359
52N-Glycan biosynthesis_Homo sapiens_hsa005100.93319843
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89949697
54Axon guidance_Homo sapiens_hsa043600.89782120
55Cell cycle_Homo sapiens_hsa041100.87957002
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87336383
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.87100420
58Pyruvate metabolism_Homo sapiens_hsa006200.86501326
59Biosynthesis of amino acids_Homo sapiens_hsa012300.83196903
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81645069
61Propanoate metabolism_Homo sapiens_hsa006400.81167838
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81004170
63Protein export_Homo sapiens_hsa030600.80459078
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76532987
65Linoleic acid metabolism_Homo sapiens_hsa005910.72755224
66Shigellosis_Homo sapiens_hsa051310.72494338
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70023542
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68540069
69Bladder cancer_Homo sapiens_hsa052190.68114153
70Fructose and mannose metabolism_Homo sapiens_hsa000510.65737257
71Ether lipid metabolism_Homo sapiens_hsa005650.64615313
72One carbon pool by folate_Homo sapiens_hsa006700.64539279
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63729957
74Non-homologous end-joining_Homo sapiens_hsa034500.62315935
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62218323
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61207239
77Fatty acid elongation_Homo sapiens_hsa000620.60693317
78Glutathione metabolism_Homo sapiens_hsa004800.60220749
79Phagosome_Homo sapiens_hsa041450.60160543
80HIF-1 signaling pathway_Homo sapiens_hsa040660.58991942
81Tight junction_Homo sapiens_hsa045300.58912302
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58696883
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58283464
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57799583
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57314677
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56153789
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55475495
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.55237308
89Thyroid hormone synthesis_Homo sapiens_hsa049180.54929271
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54396074
91Pathways in cancer_Homo sapiens_hsa052000.53241151
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52839119
93Renal cell carcinoma_Homo sapiens_hsa052110.48916949
94Mismatch repair_Homo sapiens_hsa034300.48727038
95Butanoate metabolism_Homo sapiens_hsa006500.48448801
96Nucleotide excision repair_Homo sapiens_hsa034200.48448691
97Vibrio cholerae infection_Homo sapiens_hsa051100.48168135
98Chronic myeloid leukemia_Homo sapiens_hsa052200.47608996
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47084551
100Pentose phosphate pathway_Homo sapiens_hsa000300.46952397
101RNA transport_Homo sapiens_hsa030130.46227700
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45580161
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44416563
104Cardiac muscle contraction_Homo sapiens_hsa042600.43243567
105Glioma_Homo sapiens_hsa052140.41439817
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41405710
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41377797
108Prion diseases_Homo sapiens_hsa050200.41345911
109Gap junction_Homo sapiens_hsa045400.41199898
110Ovarian steroidogenesis_Homo sapiens_hsa049130.38988706
111Arginine and proline metabolism_Homo sapiens_hsa003300.37959287
112Collecting duct acid secretion_Homo sapiens_hsa049660.36523249
113Pancreatic cancer_Homo sapiens_hsa052120.35489978
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34551401
115Colorectal cancer_Homo sapiens_hsa052100.34449874
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.34242147
117Peroxisome_Homo sapiens_hsa041460.33679504
118Hematopoietic cell lineage_Homo sapiens_hsa046400.33646061
119Rap1 signaling pathway_Homo sapiens_hsa040150.33250159
120Prostate cancer_Homo sapiens_hsa052150.32022397
121MicroRNAs in cancer_Homo sapiens_hsa052060.31062481
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30374994
123Folate biosynthesis_Homo sapiens_hsa007900.29387037
124Endometrial cancer_Homo sapiens_hsa052130.29211524
125Wnt signaling pathway_Homo sapiens_hsa043100.29167846
126Basal transcription factors_Homo sapiens_hsa030220.27252119
127Tryptophan metabolism_Homo sapiens_hsa003800.26481911
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.26291711
129HTLV-I infection_Homo sapiens_hsa051660.26255943
130ErbB signaling pathway_Homo sapiens_hsa040120.25050154
131Bile secretion_Homo sapiens_hsa049760.24831105
132Notch signaling pathway_Homo sapiens_hsa043300.23474981
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23059483
134Toxoplasmosis_Homo sapiens_hsa051450.22733985
135Vitamin B6 metabolism_Homo sapiens_hsa007500.22371354
136Insulin resistance_Homo sapiens_hsa049310.22308714
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22210156
138Osteoclast differentiation_Homo sapiens_hsa043800.19946464
139Salmonella infection_Homo sapiens_hsa051320.19260971
140Platelet activation_Homo sapiens_hsa046110.19157271
141Staphylococcus aureus infection_Homo sapiens_hsa051500.18141827
142Legionellosis_Homo sapiens_hsa051340.18086731
143Carbon metabolism_Homo sapiens_hsa012000.17094188

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