P3H3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bone trabecula formation (GO:0060346)6.95850804
2daunorubicin metabolic process (GO:0044597)5.98541178
3polyketide metabolic process (GO:0030638)5.98541178
4doxorubicin metabolic process (GO:0044598)5.98541178
5protein heterotrimerization (GO:0070208)5.62609327
6collagen fibril organization (GO:0030199)5.29399369
7notochord development (GO:0030903)4.71438210
8protein retention in ER lumen (GO:0006621)4.70740181
9skin morphogenesis (GO:0043589)4.68982751
10keratan sulfate catabolic process (GO:0042340)4.65686624
11chondrocyte proliferation (GO:0035988)4.50699833
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.44987838
13regulation of nuclear cell cycle DNA replication (GO:0033262)4.38365745
14extracellular fibril organization (GO:0043206)4.20020586
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.17890284
16basement membrane organization (GO:0071711)4.10520664
17cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.07242946
18sequestering of extracellular ligand from receptor (GO:0035581)3.99875683
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.75604385
20paraxial mesoderm development (GO:0048339)3.73199628
21regulation of response to osmotic stress (GO:0047484)3.70531507
22regulation of mammary gland epithelial cell proliferation (GO:0033599)3.69454740
23fibril organization (GO:0097435)3.59275563
24Golgi transport vesicle coating (GO:0048200)3.58626133
25COPI coating of Golgi vesicle (GO:0048205)3.58626133
26negative regulation of epidermis development (GO:0045683)3.55695661
27negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.54475898
28aminoglycoside antibiotic metabolic process (GO:0030647)3.52148380
29cell adhesion mediated by integrin (GO:0033627)3.52146393
30regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.50445915
31collagen metabolic process (GO:0032963)3.47241266
32collagen catabolic process (GO:0030574)3.46913583
33outer ear morphogenesis (GO:0042473)3.46697747
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.46338035
35cell proliferation involved in metanephros development (GO:0072203)3.45872676
36metanephric mesenchyme development (GO:0072075)3.44815156
37dermatan sulfate biosynthetic process (GO:0030208)3.40106689
38adhesion of symbiont to host cell (GO:0044650)3.39491043
39virion attachment to host cell (GO:0019062)3.39491043
40negative regulation of chondrocyte differentiation (GO:0032331)3.36687991
41middle ear morphogenesis (GO:0042474)3.36615002
42cochlea morphogenesis (GO:0090103)3.33609619
43endothelial cell morphogenesis (GO:0001886)3.33144634
44negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.32066037
45negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.29812006
46type B pancreatic cell proliferation (GO:0044342)3.29615366
47kidney mesenchyme development (GO:0072074)3.28294073
48cellular response to vitamin (GO:0071295)3.28176730
49heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.28068851
50mesenchymal-epithelial cell signaling (GO:0060638)3.25976709
51cell migration involved in heart development (GO:0060973)3.23368906
52vascular endothelial growth factor signaling pathway (GO:0038084)3.23206960
53positive regulation of blood vessel endothelial cell migration (GO:0043536)3.23101561
54peptidyl-proline hydroxylation (GO:0019511)3.22664375
55tooth mineralization (GO:0034505)3.21698667
56maintenance of protein location in nucleus (GO:0051457)3.21078312
57multicellular organismal macromolecule metabolic process (GO:0044259)3.20565704
58dermatan sulfate metabolic process (GO:0030205)3.15561881
59regulation of apoptotic process involved in morphogenesis (GO:1902337)3.14795833
60positive regulation of smoothened signaling pathway (GO:0045880)3.14692204
61extracellular matrix assembly (GO:0085029)3.14122720
62regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.10973386
63multicellular organismal catabolic process (GO:0044243)3.10323234
64negative regulation of telomerase activity (GO:0051974)3.09410226
65positive regulation of DNA-dependent DNA replication (GO:2000105)3.09242917
66regulation of G0 to G1 transition (GO:0070316)3.08075484
67endodermal cell differentiation (GO:0035987)3.07192956
68substrate-dependent cell migration (GO:0006929)3.07183762
69adhesion of symbiont to host (GO:0044406)3.06557841
70cell migration involved in sprouting angiogenesis (GO:0002042)3.05783274
71chondrocyte development (GO:0002063)3.04443120
72regulation of telomere maintenance via telomerase (GO:0032210)3.03746694
73neuron projection extension involved in neuron projection guidance (GO:1902284)3.00412741
74axon extension involved in axon guidance (GO:0048846)3.00412741
75cell-substrate junction assembly (GO:0007044)2.97232561
76protein localization to kinetochore (GO:0034501)2.96196062
77multicellular organismal metabolic process (GO:0044236)2.96000484
78embryonic skeletal joint morphogenesis (GO:0060272)2.95009824
79smooth muscle tissue development (GO:0048745)2.93338592
80adherens junction assembly (GO:0034333)2.93335022
81histone H4-K5 acetylation (GO:0043981)2.93003187
82histone H4-K8 acetylation (GO:0043982)2.93003187
83establishment of apical/basal cell polarity (GO:0035089)2.92396989
84histone H4-K12 acetylation (GO:0043983)2.90781034
85negative regulation of cell cycle G2/M phase transition (GO:1902750)2.89928818
86Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.89776165
87cell proliferation involved in kidney development (GO:0072111)2.89049122
88protein hydroxylation (GO:0018126)2.88980497
89embryonic skeletal system morphogenesis (GO:0048704)2.88469778
90negative regulation of embryonic development (GO:0045992)2.87612889
91cellular response to vitamin D (GO:0071305)2.87476903
92muscle organ morphogenesis (GO:0048644)2.86154780
93extracellular regulation of signal transduction (GO:1900115)2.85458762
94extracellular negative regulation of signal transduction (GO:1900116)2.85458762
95extracellular matrix organization (GO:0030198)2.83953424
96extracellular structure organization (GO:0043062)2.83013636
97endocardial cushion development (GO:0003197)2.82521780
98primitive streak formation (GO:0090009)2.81909642
99rRNA modification (GO:0000154)2.81754531
100negative regulation of axon extension involved in axon guidance (GO:0048843)2.80232329
101DNA damage response, detection of DNA damage (GO:0042769)2.79378361
102rRNA methylation (GO:0031167)2.79103565
103somite rostral/caudal axis specification (GO:0032525)2.78090506
104negative regulation of cartilage development (GO:0061037)2.77559740
105heparan sulfate proteoglycan metabolic process (GO:0030201)2.77089510
106regulation of establishment of planar polarity (GO:0090175)2.75693526
107cartilage condensation (GO:0001502)2.75296494
108cell aggregation (GO:0098743)2.75296494
109focal adhesion assembly (GO:0048041)2.74709578
110cell-substrate adherens junction assembly (GO:0007045)2.74709578
111convergent extension (GO:0060026)2.74687280
112apoptotic cell clearance (GO:0043277)2.72929031
113vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.72409794
114embryonic cranial skeleton morphogenesis (GO:0048701)2.71531032
115extracellular matrix disassembly (GO:0022617)2.71379388
116regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.70200282
117craniofacial suture morphogenesis (GO:0097094)2.70188470
118substrate adhesion-dependent cell spreading (GO:0034446)2.69186289
119regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.68709515
120axon extension (GO:0048675)2.68656399
121non-canonical Wnt signaling pathway (GO:0035567)2.68579141
122regulation of non-canonical Wnt signaling pathway (GO:2000050)2.68278790
123trabecula formation (GO:0060343)2.64371963
124negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.63660868
125negative regulation of smooth muscle cell migration (GO:0014912)2.63262796
126positive regulation of osteoblast proliferation (GO:0033690)2.62325715
127branching involved in mammary gland duct morphogenesis (GO:0060444)2.62151875
128lymphangiogenesis (GO:0001946)2.60995308
129negative regulation of telomere maintenance (GO:0032205)2.60777756
130regulation of plasminogen activation (GO:0010755)2.60504359
131omega-hydroxylase P450 pathway (GO:0097267)2.60462389
132positive regulation of cartilage development (GO:0061036)2.57033896
133dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.56870084
134venous blood vessel morphogenesis (GO:0048845)2.56532925
135barbed-end actin filament capping (GO:0051016)2.55599786
136rRNA transcription (GO:0009303)2.54807414
137establishment of monopolar cell polarity (GO:0061162)2.54346428
138establishment or maintenance of monopolar cell polarity (GO:0061339)2.54346428
139DNA replication checkpoint (GO:0000076)2.53640493
140mesenchymal cell proliferation (GO:0010463)2.53297977
141regulation of extracellular matrix disassembly (GO:0010715)2.52932188
142retina vasculature morphogenesis in camera-type eye (GO:0061299)2.52656479
143glomerular basement membrane development (GO:0032836)2.52496197
144wound healing, spreading of epidermal cells (GO:0035313)2.51831976
145regulation of cartilage development (GO:0061035)2.51483382
146regulation of axon extension involved in axon guidance (GO:0048841)2.51454070
147muscle cell migration (GO:0014812)2.50471280
148regulation of chondrocyte differentiation (GO:0032330)2.50346611
149wound healing, spreading of cells (GO:0044319)2.49440105
150positive regulation of axon extension (GO:0045773)2.49121103
151negative regulation of smoothened signaling pathway (GO:0045879)2.48543332
152G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.48525299
153skeletal system morphogenesis (GO:0048705)2.48277748
154blood vessel maturation (GO:0001955)2.48212284
155regulation of cardiac muscle cell apoptotic process (GO:0010665)2.47449839
156lung-associated mesenchyme development (GO:0060484)2.46688218
157protein maturation by protein folding (GO:0022417)2.46637119
158lateral sprouting from an epithelium (GO:0060601)2.45790918
159lens fiber cell development (GO:0070307)2.44484250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.05071226
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.05071226
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.05071226
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.92998036
5TP63_19390658_ChIP-ChIP_HaCaT_Human4.14916940
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.97060789
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.40591457
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.79398814
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57264333
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.45773474
11E2F7_22180533_ChIP-Seq_HELA_Human2.44384663
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.38892069
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.28762874
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.27861150
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.27738059
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.15349609
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08483246
18LXR_22292898_ChIP-Seq_THP-1_Human2.05277380
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.01229625
20CLOCK_20551151_ChIP-Seq_293T_Human2.00602128
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97863313
22TP53_20018659_ChIP-ChIP_R1E_Mouse1.95540896
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.92467138
24TCF3_18692474_ChIP-Seq_MEFs_Mouse1.91991537
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.91652139
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89308324
27NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.89117911
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.88610174
29UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.87850442
30P300_27058665_Chip-Seq_ZR-75-30cells_Human1.79727004
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.76899412
32KDM2B_26808549_Chip-Seq_K562_Human1.75599332
33TCF3_18692474_ChIP-Seq_MESCs_Mouse1.72099037
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66985414
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66448910
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.61805712
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.61365966
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59779648
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59779648
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59683196
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59189032
42RACK7_27058665_Chip-Seq_MCF-7_Human1.57318013
43SMC3_22415368_ChIP-Seq_MEFs_Mouse1.56437018
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55015649
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53962244
46NANOG_16153702_ChIP-ChIP_HESCs_Human1.52984865
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52503252
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49627196
49TP53_22127205_ChIP-Seq_IMR90_Human1.46339268
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45445408
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45170179
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44424669
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43802837
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42593200
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.39642437
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38506849
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.38189101
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38177395
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37772269
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36425575
61TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.36129171
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35912535
63NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.33843627
64BRD4_25478319_ChIP-Seq_HGPS_Human1.33801281
65NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.33322400
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32686216
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32208309
68TET1_21490601_ChIP-Seq_MESCs_Mouse1.32017450
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.31915290
70CJUN_26792858_Chip-Seq_BT549_Human1.31188476
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29745094
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28645037
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.28518132
74OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28261685
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.27941711
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27621051
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26836595
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26066590
79CTCF_27219007_Chip-Seq_Bcells_Human1.24785072
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24683387
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23909995
82ZNF263_19887448_ChIP-Seq_K562_Human1.23893291
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.21713410
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20938173
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20385889
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.19997226
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.18295820
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17789968
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17509185
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17452309
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16512012
92POU5F1_16518401_ChIP-PET_MESCs_Mouse1.15587493
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15045085
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14823310
95ATF3_27146783_Chip-Seq_COLON_Human1.14044318
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14015780
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13806565
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13335243
99SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13197321
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.13011056
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12889619
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11787457
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11561289
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11507342
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.11461714
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.11249920
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10779268
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10544291
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08760074
110SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08310581
111TP53_23651856_ChIP-Seq_MEFs_Mouse1.07344579
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.06812996
113EZH2_27294783_Chip-Seq_ESCs_Mouse1.05960111
114ELK3_25401928_ChIP-Seq_HUVEC_Human1.05575693
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05184670
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04258044
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03550327
118SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03404016
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.03166511
120SA1_22415368_ChIP-Seq_MEFs_Mouse1.02417260
121SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01982792
122NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01419424
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01318948
124DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00506455
125SOX2_16153702_ChIP-ChIP_HESCs_Human1.00484187
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99784662
127MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99511180
128KDM2B_26808549_Chip-Seq_DND41_Human0.99227337
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99093463
130SA1_27219007_Chip-Seq_ERYTHROID_Human0.98979977
131PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.97639388
132BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97606502
133SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97202605
134ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96798524
135CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96684360
136CDX2_20551321_ChIP-Seq_CACO-2_Human0.96350518
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95909240
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94657432
139ESR1_21235772_ChIP-Seq_MCF-7_Human0.94116699
140SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92763575
141FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92237908
142NANOG_16518401_ChIP-PET_MESCs_Mouse0.91477336
143FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90906949
144E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89164705
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88662578
146DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88370354
147RING1B_27294783_Chip-Seq_ESCs_Mouse0.86602517
148SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86285712
149SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85545256
150TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85525620
151NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84013290
152TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83219784
153KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.81897742
154POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81681749
155NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81225606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.99420751
2MP0005503_abnormal_tendon_morphology5.20081258
3MP0005275_abnormal_skin_tensile3.86229288
4MP0005257_abnormal_intraocular_pressure3.40025171
5MP0010030_abnormal_orbit_morphology3.02315149
6MP0003279_aneurysm2.91776892
7MP0003705_abnormal_hypodermis_morpholog2.63018258
8MP0005508_abnormal_skeleton_morphology2.56771248
9MP0003122_maternal_imprinting2.52588078
10MP0006292_abnormal_olfactory_placode2.33656288
11MP0009250_abnormal_appendicular_skeleto2.23722597
12MP0001958_emphysema2.20627319
13MP0004272_abnormal_basement_membrane2.17508252
14MP0000049_abnormal_middle_ear2.14987289
15MP0005623_abnormal_meninges_morphology2.03772485
16MP0000013_abnormal_adipose_tissue1.92190706
17MP0002932_abnormal_joint_morphology1.91097961
18MP0009780_abnormal_chondrocyte_physiolo1.85177256
19MP0003385_abnormal_body_wall1.83229606
20MP0002108_abnormal_muscle_morphology1.80180777
21MP0002249_abnormal_larynx_morphology1.70090323
22MP0000751_myopathy1.64981696
23MP0000762_abnormal_tongue_morphology1.64554625
24MP0003755_abnormal_palate_morphology1.63546222
25MP0003121_genomic_imprinting1.62240341
26MP0000678_abnormal_parathyroid_gland1.61588242
27MP0000428_abnormal_craniofacial_morphol1.60508561
28MP0002233_abnormal_nose_morphology1.55475031
29MP0003123_paternal_imprinting1.53912918
30MP0000163_abnormal_cartilage_morphology1.52317482
31MP0003283_abnormal_digestive_organ1.52162227
32MP0005394_taste/olfaction_phenotype1.48919449
33MP0005499_abnormal_olfactory_system1.48919449
34MP0003941_abnormal_skin_development1.48782173
35MP0004858_abnormal_nervous_system1.48360265
36MP0003942_abnormal_urinary_system1.47701432
37MP0004134_abnormal_chest_morphology1.43334277
38MP0000534_abnormal_ureter_morphology1.39996944
39MP0006054_spinal_hemorrhage1.39827782
40MP0002116_abnormal_craniofacial_bone1.36769325
41MP0003937_abnormal_limbs/digits/tail_de1.36655064
42MP0002114_abnormal_axial_skeleton1.34229530
43MP0003935_abnormal_craniofacial_develop1.33474567
44MP0000003_abnormal_adipose_tissue1.32430692
45MP0009384_cardiac_valve_regurgitation1.31468211
46MP0000432_abnormal_head_morphology1.29608613
47MP0001542_abnormal_bone_strength1.29537799
48MP0002109_abnormal_limb_morphology1.25102611
49MP0005390_skeleton_phenotype1.24516166
50MP0002282_abnormal_trachea_morphology1.23964081
51MP0005171_absent_coat_pigmentation1.23848824
52MP0003938_abnormal_ear_development1.21608098
53MP0002060_abnormal_skin_morphology1.20668317
54MP0002938_white_spotting1.19157030
55MP0002115_abnormal_skeleton_extremities1.17466389
56MP0002295_abnormal_pulmonary_circulatio1.16413524
57MP0003011_delayed_dark_adaptation1.16145815
58MP0003950_abnormal_plasma_membrane1.13270403
59MP0010368_abnormal_lymphatic_system1.12856389
60MP0002877_abnormal_melanocyte_morpholog1.09803293
61MP0000767_abnormal_smooth_muscle1.09390403
62MP0002113_abnormal_skeleton_development1.09044077
63MP0005595_abnormal_vascular_smooth1.08314505
64MP0001270_distended_abdomen1.08187715
65MP0005023_abnormal_wound_healing1.07532982
66MP0001243_abnormal_dermal_layer1.06239249
67MP0005367_renal/urinary_system_phenotyp1.06041575
68MP0000516_abnormal_urinary_system1.06041575
69MP0001879_abnormal_lymphatic_vessel1.05822119
70MP0001293_anophthalmia1.05148540
71MP0003566_abnormal_cell_adhesion1.02876320
72MP0000566_synostosis0.98966063
73MP0009053_abnormal_anal_canal0.98745446
74MP0000733_abnormal_muscle_development0.97461057
75MP0002896_abnormal_bone_mineralization0.95935518
76MP0002111_abnormal_tail_morphology0.94301769
77MP0008789_abnormal_olfactory_epithelium0.94149307
78MP0010352_gastrointestinal_tract_polyps0.94008456
79MP0005248_abnormal_Harderian_gland0.91985585
80MP0005197_abnormal_uvea_morphology0.88732715
81MP0000537_abnormal_urethra_morphology0.88424916
82MP0001915_intracranial_hemorrhage0.87999466
83MP0003890_abnormal_embryonic-extraembry0.86043259
84MP0002697_abnormal_eye_size0.85722218
85MP0003115_abnormal_respiratory_system0.85549935
86MP0002092_abnormal_eye_morphology0.84973740
87MP0004859_abnormal_synaptic_plasticity0.84365307
88MP0003315_abnormal_perineum_morphology0.83281395
89MP0000759_abnormal_skeletal_muscle0.82891972
90MP0001849_ear_inflammation0.81687807
91MP0005075_abnormal_melanosome_morpholog0.81679302
92MP0000462_abnormal_digestive_system0.81374327
93MP0008007_abnormal_cellular_replicative0.81192401
94MP0003119_abnormal_digestive_system0.79180648
95MP0002089_abnormal_postnatal_growth/wei0.77189108
96MP0002177_abnormal_outer_ear0.77008428
97MP0002128_abnormal_blood_circulation0.76095421
98MP0001348_abnormal_lacrimal_gland0.75139570
99MP0002925_abnormal_cardiovascular_devel0.74589125
100MP0001175_abnormal_lung_morphology0.74539279
101MP0000750_abnormal_muscle_regeneration0.73976571
102MP0004264_abnormal_extraembryonic_tissu0.73326471
103MP0003091_abnormal_cell_migration0.73164882
104MP0002085_abnormal_embryonic_tissue0.72938679
105MP0002933_joint_inflammation0.72383983
106MP0002127_abnormal_cardiovascular_syste0.70227451
107MP0005380_embryogenesis_phenotype0.68268906
108MP0001672_abnormal_embryogenesis/_devel0.68268906
109MP0000749_muscle_degeneration0.68211061
110MP0002254_reproductive_system_inflammat0.67128727
111MP0004233_abnormal_muscle_weight0.66233755
112MP0001614_abnormal_blood_vessel0.66050390
113MP0004197_abnormal_fetal_growth/weight/0.65944189
114MP0010386_abnormal_urinary_bladder0.65737929
115MP0005193_abnormal_anterior_eye0.65726551
116MP0001286_abnormal_eye_development0.65452089
117MP0005058_abnormal_lysosome_morphology0.65123363
118MP0001299_abnormal_eye_distance/0.64996108
119MP0005369_muscle_phenotype0.64428427
120MP0004133_heterotaxia0.64310195
121MP0000538_abnormal_urinary_bladder0.58981457
122MP0005409_darkened_coat_color0.58493440
123MP0002084_abnormal_developmental_patter0.50347568
124MP0009840_abnormal_foam_cell0.49732023
125MP0004087_abnormal_muscle_fiber0.49005132

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.70460745
2Premature rupture of membranes (HP:0001788)5.89456914
3Neonatal short-limb short stature (HP:0008921)3.98643425
4Vascular tortuosity (HP:0004948)3.90077754
5Ankle contracture (HP:0006466)3.77363006
6Abnormality of dentin (HP:0010299)3.74695958
7Soft skin (HP:0000977)3.58454194
8Arterial tortuosity (HP:0005116)3.54149199
9Broad metatarsal (HP:0001783)3.47857063
10Shallow orbits (HP:0000586)3.43475341
11Bladder diverticulum (HP:0000015)3.42866196
12Peritonitis (HP:0002586)3.34762260
13Mesomelia (HP:0003027)3.29317172
14Aortic dissection (HP:0002647)3.28250426
15Atrophic scars (HP:0001075)3.25555325
16Bilateral microphthalmos (HP:0007633)3.22447094
17Follicular hyperkeratosis (HP:0007502)3.06714652
18Hepatoblastoma (HP:0002884)2.99307388
19Cervical subluxation (HP:0003308)2.84055099
20Biconcave vertebral bodies (HP:0004586)2.79440143
21Genu recurvatum (HP:0002816)2.78259881
22Hypoventilation (HP:0002791)2.73773050
23Fragile skin (HP:0001030)2.64192257
24Increased connective tissue (HP:0009025)2.57753243
25Vertebral compression fractures (HP:0002953)2.55891518
26Blue sclerae (HP:0000592)2.55085600
27Mildly elevated creatine phosphokinase (HP:0008180)2.54719579
28Mild short stature (HP:0003502)2.54538295
29Renal duplication (HP:0000075)2.53245186
30Wormian bones (HP:0002645)2.52625155
31Elbow flexion contracture (HP:0002987)2.52553372
32Breech presentation (HP:0001623)2.50556039
33Type 1 muscle fiber predominance (HP:0003803)2.48972547
34Abnormality of the phalanges of the hallux (HP:0010057)2.44276051
35Bowel diverticulosis (HP:0005222)2.42797384
36Wide anterior fontanel (HP:0000260)2.42670235
37Disproportionate tall stature (HP:0001519)2.42580198
38Dilatation of the ascending aorta (HP:0005111)2.40712163
39Coronal craniosynostosis (HP:0004440)2.37274509
40Aortic regurgitation (HP:0001659)2.35716588
41Mitral valve prolapse (HP:0001634)2.34387714
42Spinal rigidity (HP:0003306)2.33744569
43Wrist flexion contracture (HP:0001239)2.32884367
44Overgrowth (HP:0001548)2.32528614
45Aortic aneurysm (HP:0004942)2.31425368
46Cerebral aneurysm (HP:0004944)2.28819600
47Spondylolisthesis (HP:0003302)2.28655063
48Nonimmune hydrops fetalis (HP:0001790)2.25872587
49Premature skin wrinkling (HP:0100678)2.24791876
50Upper limb amyotrophy (HP:0009129)2.23734796
51Distal upper limb amyotrophy (HP:0007149)2.23734796
52Turricephaly (HP:0000262)2.23308052
53Hyperacusis (HP:0010780)2.20583654
54Osteoarthritis (HP:0002758)2.20518540
55Broad long bones (HP:0005622)2.19458285
56Slender build (HP:0001533)2.17461657
57Ectopia lentis (HP:0001083)2.16130870
58Fused cervical vertebrae (HP:0002949)2.12796381
59Abnormality of the acetabulum (HP:0003170)2.12300060
60Abnormal delivery (HP:0001787)2.11903831
61Short 4th metacarpal (HP:0010044)2.11529281
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.11529281
63Bowing of the arm (HP:0006488)2.11460197
64Bowed forearm bones (HP:0003956)2.11460197
65Long toe (HP:0010511)2.10755730
66Embryonal renal neoplasm (HP:0011794)2.09454244
67Rib fusion (HP:0000902)2.08724512
68Nephroblastoma (Wilms tumor) (HP:0002667)2.08410014
69Short nail (HP:0001799)2.07636208
70Aneurysm (HP:0002617)2.04940369
71Joint stiffness (HP:0001387)2.04325505
72Hyperextensible skin (HP:0000974)2.04275607
73Dislocated radial head (HP:0003083)2.03422489
74Increased variability in muscle fiber diameter (HP:0003557)2.02807966
75Inguinal hernia (HP:0000023)2.01982192
76Short 5th finger (HP:0009237)2.01527865
77Abnormality of the pubic bones (HP:0003172)2.00884690
78Abnormality of the distal phalanx of the thumb (HP:0009617)2.00668925
79Joint laxity (HP:0001388)2.00420269
80Deviation of the hallux (HP:0010051)1.99793956
81Congenital glaucoma (HP:0001087)1.98876935
82Partial duplication of the phalanx of hand (HP:0009999)1.98396577
83Hypoplasia of the fovea (HP:0007750)1.98012293
84Aplasia/Hypoplasia of the fovea (HP:0008060)1.98012293
85Round ear (HP:0100830)1.97637932
86Achilles tendon contracture (HP:0001771)1.97289145
87Short middle phalanx of the 5th finger (HP:0004220)1.95592418
88Trismus (HP:0000211)1.95464176
89Aortic valve stenosis (HP:0001650)1.93389858
90Abnormality of the radial head (HP:0003995)1.92475343
91Hand muscle atrophy (HP:0009130)1.91306697
92Hip contracture (HP:0003273)1.90327824
93Infantile muscular hypotonia (HP:0008947)1.89924146
94Spinal cord compression (HP:0002176)1.89199795
95Hallux valgus (HP:0001822)1.88846277
96Ulnar bowing (HP:0003031)1.88519718
97Morphological abnormality of the middle ear (HP:0008609)1.88467899
98Radial bowing (HP:0002986)1.88172710
99Broad phalanx (HP:0006009)1.87920179
100Mitral regurgitation (HP:0001653)1.86658258
101Bell-shaped thorax (HP:0001591)1.86539271
102Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.84946535
103Mitral stenosis (HP:0001718)1.84732162
104Hypoplastic ischia (HP:0003175)1.81826806
105Broad toe (HP:0001837)1.81538066
106Flat capital femoral epiphysis (HP:0003370)1.80587574
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79675834
108Abnormality of skeletal muscle fiber size (HP:0012084)1.79065714
109Absent frontal sinuses (HP:0002688)1.78647725
110Selective tooth agenesis (HP:0001592)1.78614573
111Decreased skull ossification (HP:0004331)1.75599784
112Generalized amyotrophy (HP:0003700)1.75050993
113Abnormality of the 4th metacarpal (HP:0010012)1.74785706
114Coxa vara (HP:0002812)1.74674205
115Venous insufficiency (HP:0005293)1.74568039
116Bifid tongue (HP:0010297)1.73280358
117Arachnodactyly (HP:0001166)1.73254913
118Slender long bone (HP:0003100)1.73096789
119Stridor (HP:0010307)1.72761672
120Abnormality of the Achilles tendon (HP:0005109)1.72615627
121Broad thumb (HP:0011304)1.72614139
122Limb-girdle muscle weakness (HP:0003325)1.72170372
123Natal tooth (HP:0000695)1.71684518
124Protruding ear (HP:0000411)1.70901142
125Narrow nasal bridge (HP:0000446)1.69849908
126Broad finger (HP:0001500)1.69469714
127Delayed cranial suture closure (HP:0000270)1.69443495
128Venous abnormality (HP:0002624)1.69247603
129Flat cornea (HP:0007720)1.69165054
130Spinal cord lesions (HP:0100561)1.68773151
131Syringomyelia (HP:0003396)1.68773151
132Broad phalanges of the hand (HP:0009768)1.67193754
133Shawl scrotum (HP:0000049)1.66986539
134Camptodactyly of toe (HP:0001836)1.66810362
135Limited hip movement (HP:0008800)1.66535789
136Synostosis of carpal bones (HP:0005048)1.66223744
137Osteolytic defects of the hand bones (HP:0009699)1.65354129
138Osteolytic defects of the phalanges of the hand (HP:0009771)1.65354129
139Buphthalmos (HP:0000557)1.64702041
140Insomnia (HP:0100785)1.64611110
141Abnormality of the humeroradial joint (HP:0100744)1.64144567
142Thin ribs (HP:0000883)1.64140070
143Pulmonary artery stenosis (HP:0004415)1.64075207
144Platyspondyly (HP:0000926)1.63464241
145Congenital hip dislocation (HP:0001374)1.62896407
146Osteopenia (HP:0000938)1.62686861
147Broad ribs (HP:0000885)1.61954886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.47456006
2DDR25.07517097
3ERN13.89361762
4GRK53.38278401
5LATS23.11967809
6TGFBR23.08260198
7LATS12.51697640
8PDGFRA2.40934377
9ZAK2.33456081
10GRK12.26552524
11TTK2.23437619
12ADRBK22.08957800
13PAK42.02361519
14MAPK71.95560550
15LIMK11.95408660
16EEF2K1.90350375
17ICK1.78736284
18IRAK31.76812482
19SMG11.74063293
20EPHA31.73838124
21CSF1R1.70690397
22FLT31.69716200
23MOS1.64354858
24STK38L1.60033091
25AKT31.58980367
26WNK11.58672454
27TESK11.51069184
28TTN1.48322268
29EPHB21.45932182
30PRKD31.44502665
31CDK71.36849587
32FGFR41.35126722
33MKNK11.33576788
34MATK1.26411019
35PAK61.26059310
36TYRO31.23562824
37GRK61.20985794
38ADRBK11.20863818
39GRK71.20000106
40CAMK41.18801418
41RPS6KA21.16819087
42DAPK31.11122596
43NEK21.10973659
44MKNK21.08713194
45MAP3K101.07221449
46LMTK21.06807336
47CHEK21.06330669
48EPHA21.05554989
49SRPK11.04755072
50NEK91.02758370
51EIF2AK21.02044942
52CDK81.01944078
53ERBB30.99793746
54PRKG20.99470595
55BMX0.98335031
56PLK10.96797785
57NTRK10.95736162
58TAOK20.95499286
59PAK20.93128412
60SIK10.92112050
61PRPF4B0.90184962
62PTK20.89482752
63CDC42BPA0.87453280
64MARK20.86198963
65ARAF0.86183198
66MAP3K60.83840017
67FGFR20.82924713
68ERBB40.81214398
69ABL20.81206488
70PRKCI0.80545831
71PINK10.80170422
72ILK0.80061457
73TRPM70.78804190
74TRIB30.77511553
75BUB10.76113337
76PTK2B0.74076021
77RIPK10.73954681
78PLK40.71162522
79PLK20.70939949
80PRKD20.67845911
81MARK10.67443362
82BRAF0.66174964
83WNK40.65623028
84CDK11A0.64794458
85MTOR0.62319028
86MAP2K30.61980802
87CDK150.60764025
88STK30.59612466
89RPS6KC10.59242118
90RPS6KL10.59242118
91MYLK0.58655265
92STK380.58274885
93PIM20.58079680
94AKT20.57780176
95FGFR30.57382030
96PTK60.56934141
97MAPKAPK30.55481078
98PIK3CG0.55015269
99PAK10.54893279
100CDK180.52483570
101HIPK20.51503351
102CHEK10.49561098
103ROCK10.49558373
104CDK140.49505338
105MAP3K90.49231659
106ALK0.47919904
107CAMK1G0.47226787
108MAP3K80.46826097
109PLK30.46645177
110FGFR10.44361171
111EPHB10.44254304
112STK100.44229220
113TIE10.43553948
114DYRK1B0.43478147
115CAMK2G0.42904731
116MAP3K30.42199956
117DMPK0.41873957
118RPS6KA60.39870918
119FER0.39303216
120TGFBR10.39077581
121KDR0.39020013
122GSK3A0.38811990
123PDGFRB0.38046192
124PKN20.37505990
125NTRK30.37297439
126PIK3CA0.37039613
127CLK10.36394680
128NME10.36387850
129EPHA40.36333092
130MELK0.35431248
131ERBB20.35384892
132ATR0.34709592
133PDPK10.34477314
134CAMK2D0.34417551
135BRSK10.34286360
136MET0.33031926
137PAK30.32716483
138AURKA0.32605036
139KSR20.32419690
140INSR0.30940168
141IKBKB0.29830340
142NUAK10.29797032
143NEK60.29736045
144IGF1R0.27881750
145MAPK10.27798095
146CDK20.26650089
147BRSK20.26401522
148IRAK10.25882985
149RPS6KB20.24403136
150CHUK0.24118093
151AURKB0.23267703
152ROCK20.23258218
153MAP3K70.23072887

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.24289291
2ECM-receptor interaction_Homo sapiens_hsa045123.24148790
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.48254875
4Protein digestion and absorption_Homo sapiens_hsa049742.39298246
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27334162
6Basal cell carcinoma_Homo sapiens_hsa052172.09822190
7Focal adhesion_Homo sapiens_hsa045101.93584138
8Hedgehog signaling pathway_Homo sapiens_hsa043401.88244467
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.70401692
10Dilated cardiomyopathy_Homo sapiens_hsa054141.51745990
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51078186
12Arachidonic acid metabolism_Homo sapiens_hsa005901.50634890
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50325333
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46170715
15TGF-beta signaling pathway_Homo sapiens_hsa043501.45509074
16Hippo signaling pathway_Homo sapiens_hsa043901.45283462
17Galactose metabolism_Homo sapiens_hsa000521.44655104
18Proteoglycans in cancer_Homo sapiens_hsa052051.44133575
19Cell cycle_Homo sapiens_hsa041101.38233225
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.38213011
21Fructose and mannose metabolism_Homo sapiens_hsa000511.34865220
22MicroRNAs in cancer_Homo sapiens_hsa052061.34592581
23Fanconi anemia pathway_Homo sapiens_hsa034601.33876641
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.32920952
25p53 signaling pathway_Homo sapiens_hsa041151.32279129
26N-Glycan biosynthesis_Homo sapiens_hsa005101.25593158
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25534521
28Malaria_Homo sapiens_hsa051441.24826614
29Ribosome_Homo sapiens_hsa030101.24245582
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21866465
31Wnt signaling pathway_Homo sapiens_hsa043101.19144233
32Bladder cancer_Homo sapiens_hsa052191.18065147
33DNA replication_Homo sapiens_hsa030301.16828272
34Pathways in cancer_Homo sapiens_hsa052001.15031834
35Melanoma_Homo sapiens_hsa052181.14309888
36Vitamin B6 metabolism_Homo sapiens_hsa007501.13769740
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12582773
38RNA polymerase_Homo sapiens_hsa030201.12355002
39Sulfur relay system_Homo sapiens_hsa041221.11258411
40Adherens junction_Homo sapiens_hsa045201.10481930
41RNA transport_Homo sapiens_hsa030131.09776456
42Spliceosome_Homo sapiens_hsa030401.09698804
43Vibrio cholerae infection_Homo sapiens_hsa051101.08705766
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.04423476
45Prion diseases_Homo sapiens_hsa050201.04109069
46Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03408446
47Ovarian steroidogenesis_Homo sapiens_hsa049131.03162083
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03036063
49RNA degradation_Homo sapiens_hsa030180.99120428
50Small cell lung cancer_Homo sapiens_hsa052220.96086712
51Lysine degradation_Homo sapiens_hsa003100.93363193
52Rap1 signaling pathway_Homo sapiens_hsa040150.91007731
53Base excision repair_Homo sapiens_hsa034100.90696170
54HTLV-I infection_Homo sapiens_hsa051660.90407876
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89676678
56Amoebiasis_Homo sapiens_hsa051460.89011378
57Homologous recombination_Homo sapiens_hsa034400.88110572
58Notch signaling pathway_Homo sapiens_hsa043300.85535664
59Pentose phosphate pathway_Homo sapiens_hsa000300.84676704
60Melanogenesis_Homo sapiens_hsa049160.82881006
61Thyroid hormone synthesis_Homo sapiens_hsa049180.82783674
62mTOR signaling pathway_Homo sapiens_hsa041500.82775621
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81192828
64mRNA surveillance pathway_Homo sapiens_hsa030150.81182539
65Thyroid cancer_Homo sapiens_hsa052160.80112893
66Biosynthesis of amino acids_Homo sapiens_hsa012300.80082911
67Other glycan degradation_Homo sapiens_hsa005110.79763462
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78869092
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77914730
70Axon guidance_Homo sapiens_hsa043600.77383695
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.77275609
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73042325
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72780188
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.69714616
75Chronic myeloid leukemia_Homo sapiens_hsa052200.68690901
76Basal transcription factors_Homo sapiens_hsa030220.68321222
77Prostate cancer_Homo sapiens_hsa052150.67854802
78Cocaine addiction_Homo sapiens_hsa050300.66749097
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66624431
80Ras signaling pathway_Homo sapiens_hsa040140.66510244
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.64710452
82Estrogen signaling pathway_Homo sapiens_hsa049150.62578066
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.62322287
84Pyrimidine metabolism_Homo sapiens_hsa002400.61843589
85Insulin secretion_Homo sapiens_hsa049110.59550600
86Nucleotide excision repair_Homo sapiens_hsa034200.59367627
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58328424
88Sphingolipid metabolism_Homo sapiens_hsa006000.58316750
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57572656
90AMPK signaling pathway_Homo sapiens_hsa041520.56650450
91VEGF signaling pathway_Homo sapiens_hsa043700.55919935
92Mismatch repair_Homo sapiens_hsa034300.55131297
93Colorectal cancer_Homo sapiens_hsa052100.54994030
94Glioma_Homo sapiens_hsa052140.54600824
95Non-small cell lung cancer_Homo sapiens_hsa052230.52735325
96Lysosome_Homo sapiens_hsa041420.51986145
97Acute myeloid leukemia_Homo sapiens_hsa052210.51844640
98Platelet activation_Homo sapiens_hsa046110.51656728
99Purine metabolism_Homo sapiens_hsa002300.51461863
100Glucagon signaling pathway_Homo sapiens_hsa049220.51421265
101GnRH signaling pathway_Homo sapiens_hsa049120.50760410
102Pancreatic cancer_Homo sapiens_hsa052120.50294413
103One carbon pool by folate_Homo sapiens_hsa006700.49468338
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48936760
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47686599
106HIF-1 signaling pathway_Homo sapiens_hsa040660.47649803
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47523241
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47063858
109Choline metabolism in cancer_Homo sapiens_hsa052310.47038648
110ErbB signaling pathway_Homo sapiens_hsa040120.47003875
111Taste transduction_Homo sapiens_hsa047420.46882632
112Apoptosis_Homo sapiens_hsa042100.46843859
113MAPK signaling pathway_Homo sapiens_hsa040100.46231224
114Tight junction_Homo sapiens_hsa045300.45393254
115Long-term depression_Homo sapiens_hsa047300.44845419
116Calcium signaling pathway_Homo sapiens_hsa040200.44566529
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.43787605
118Endocytosis_Homo sapiens_hsa041440.43300190
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43266128
120Insulin signaling pathway_Homo sapiens_hsa049100.41951996
121Serotonergic synapse_Homo sapiens_hsa047260.41731225
122Gap junction_Homo sapiens_hsa045400.41553518
123Shigellosis_Homo sapiens_hsa051310.40677805
124Endometrial cancer_Homo sapiens_hsa052130.40359234
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40162957
126cAMP signaling pathway_Homo sapiens_hsa040240.40078231
127Glutamatergic synapse_Homo sapiens_hsa047240.38894947
128Arginine and proline metabolism_Homo sapiens_hsa003300.38504714
129Oxytocin signaling pathway_Homo sapiens_hsa049210.38188834
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37108680
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36987284
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.36662190
133Herpes simplex infection_Homo sapiens_hsa051680.36560361
134Renal cell carcinoma_Homo sapiens_hsa052110.34613536
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33601134
136Cholinergic synapse_Homo sapiens_hsa047250.32230448
137Complement and coagulation cascades_Homo sapiens_hsa046100.31602491

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