P3H4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This nucleolar protein was first characterized because it was an autoantigen in cases on interstitial cystitis. The protein, with a predicted molecular weight of 50 kDa, appears to be localized in the particulate compartment of the interphase nucleolus, with a distribution distinct from that of nucleolar protein B23. During mitosis it is associated with chromosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)5.37894956
2axon ensheathment in central nervous system (GO:0032291)5.10206499
3central nervous system myelination (GO:0022010)5.10206499
4bone trabecula formation (GO:0060346)4.91817414
5chondrocyte proliferation (GO:0035988)4.89709849
6protein heterotrimerization (GO:0070208)4.74425661
7skin morphogenesis (GO:0043589)4.23473455
8cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.07728048
9peptidyl-proline hydroxylation (GO:0019511)3.86471961
10adhesion of symbiont to host cell (GO:0044650)3.67879533
11virion attachment to host cell (GO:0019062)3.67879533
12sequestering of extracellular ligand from receptor (GO:0035581)3.67110919
13endocardial cushion development (GO:0003197)3.59921234
14collagen metabolic process (GO:0032963)3.55110176
15axon ensheathment (GO:0008366)3.54638304
16ensheathment of neurons (GO:0007272)3.54638304
17endodermal cell differentiation (GO:0035987)3.53979965
18collagen catabolic process (GO:0030574)3.51539802
19myelination (GO:0042552)3.50514916
20chondrocyte development (GO:0002063)3.50113234
21craniofacial suture morphogenesis (GO:0097094)3.37146305
22polarized epithelial cell differentiation (GO:0030859)3.30457072
23multicellular organismal macromolecule metabolic process (GO:0044259)3.29256049
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.27071008
25outer ear morphogenesis (GO:0042473)3.26657857
26multicellular organismal catabolic process (GO:0044243)3.26615346
27protein retention in ER lumen (GO:0006621)3.26453178
28behavioral response to nicotine (GO:0035095)3.24503202
29myelin maintenance (GO:0043217)3.24385955
30water-soluble vitamin biosynthetic process (GO:0042364)3.22558913
31somite development (GO:0061053)3.16178887
32extracellular matrix assembly (GO:0085029)3.15134308
33multicellular organismal metabolic process (GO:0044236)3.12667329
34cellular response to vitamin D (GO:0071305)3.12418278
35endothelial cell morphogenesis (GO:0001886)3.11429413
36middle ear morphogenesis (GO:0042474)3.11016265
37extracellular matrix disassembly (GO:0022617)3.10452707
38retina vasculature morphogenesis in camera-type eye (GO:0061299)3.08977436
39regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.01615833
40dermatan sulfate biosynthetic process (GO:0030208)3.01286342
41cranial suture morphogenesis (GO:0060363)3.00202031
42planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99138484
43cellular response to vitamin (GO:0071295)2.99090376
44regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.98636017
45wound healing, spreading of cells (GO:0044319)2.96752669
46negative regulation of axon guidance (GO:1902668)2.95178427
47protein hydroxylation (GO:0018126)2.93686795
48extracellular fibril organization (GO:0043206)2.93045381
49mesenchymal-epithelial cell signaling (GO:0060638)2.93021278
50adhesion of symbiont to host (GO:0044406)2.91660556
51negative regulation of axon extension involved in axon guidance (GO:0048843)2.90749776
52basement membrane organization (GO:0071711)2.89238931
53fatty acid elongation (GO:0030497)2.89044642
54kidney mesenchyme development (GO:0072074)2.88950897
55negative regulation of catenin import into nucleus (GO:0035414)2.87942861
56glomerular basement membrane development (GO:0032836)2.87579209
57peripheral nervous system axon ensheathment (GO:0032292)2.85977886
58myelination in peripheral nervous system (GO:0022011)2.85977886
59metanephric mesenchyme development (GO:0072075)2.85866808
60regulation of mitochondrial translation (GO:0070129)2.84935980
61limb bud formation (GO:0060174)2.84931334
62atrioventricular valve morphogenesis (GO:0003181)2.84849793
63wound healing, spreading of epidermal cells (GO:0035313)2.83153933
64Golgi transport vesicle coating (GO:0048200)2.81229568
65COPI coating of Golgi vesicle (GO:0048205)2.81229568
66extracellular matrix organization (GO:0030198)2.80294915
67extracellular structure organization (GO:0043062)2.79001854
68embryonic cranial skeleton morphogenesis (GO:0048701)2.78155791
69astrocyte development (GO:0014002)2.76706373
70negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.75352793
71negative regulation of chondrocyte differentiation (GO:0032331)2.73469591
72hemidesmosome assembly (GO:0031581)2.72958595
73mesenchymal cell proliferation (GO:0010463)2.72851320
74pattern specification involved in kidney development (GO:0061004)2.70126724
75epithelial cell-cell adhesion (GO:0090136)2.69178204
76dermatan sulfate metabolic process (GO:0030205)2.68546516
77negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.67785825
78cell adhesion mediated by integrin (GO:0033627)2.66556218
79regulation of establishment of planar polarity (GO:0090175)2.65747436
80positive regulation of osteoblast proliferation (GO:0033690)2.65450453
81convergent extension (GO:0060026)2.64641080
82Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.64549413
83short-term memory (GO:0007614)2.62336886
84apical protein localization (GO:0045176)2.61895864
85G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.61696569
86branching involved in salivary gland morphogenesis (GO:0060445)2.61345112
87trabecula formation (GO:0060343)2.60348207
88regulation of cardioblast differentiation (GO:0051890)2.58779897
89regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.58032510
90mesenchyme development (GO:0060485)2.57688138
91protein localization to cell surface (GO:0034394)2.57123882
92protein targeting to plasma membrane (GO:0072661)2.56838467
93negative regulation of embryonic development (GO:0045992)2.56490456
94cochlea morphogenesis (GO:0090103)2.56049472
95glomerular filtration (GO:0003094)2.55047095
96positive regulation of cartilage development (GO:0061036)2.54891334
97renal system development (GO:0072001)2.54527555
98establishment of planar polarity (GO:0001736)2.54500488
99establishment of tissue polarity (GO:0007164)2.54500488
100regulation of axon guidance (GO:1902667)2.54461708
101lateral sprouting from an epithelium (GO:0060601)2.54424430
102axon extension involved in axon guidance (GO:0048846)2.52904882
103neuron projection extension involved in neuron projection guidance (GO:1902284)2.52904882
104endochondral ossification (GO:0001958)2.52174095
105replacement ossification (GO:0036075)2.52174095
106positive regulation of endothelial cell apoptotic process (GO:2000353)2.52094004
107plasma membrane repair (GO:0001778)2.51649433
108non-canonical Wnt signaling pathway (GO:0035567)2.49611743
109extracellular regulation of signal transduction (GO:1900115)2.48574020
110extracellular negative regulation of signal transduction (GO:1900116)2.48574020
111negative regulation of cartilage development (GO:0061037)2.47632611
112mannosylation (GO:0097502)2.47461024
113cell migration involved in heart development (GO:0060973)2.47415637
114protein complex biogenesis (GO:0070271)2.47363822
115regulation of hippo signaling (GO:0035330)2.46692194
116organ induction (GO:0001759)2.46524617
117regulation of axon extension involved in axon guidance (GO:0048841)2.46375621
118embryonic skeletal joint morphogenesis (GO:0060272)2.45548126
119nephron tubule morphogenesis (GO:0072078)2.44711228
120nephron epithelium morphogenesis (GO:0072088)2.44711228
121head development (GO:0060322)2.43737336
122lung vasculature development (GO:0060426)2.41896849
123lung-associated mesenchyme development (GO:0060484)2.38915900
124regulation of organ formation (GO:0003156)2.38123472
125mitochondrial respiratory chain complex assembly (GO:0033108)2.36774261
126L-serine metabolic process (GO:0006563)2.34583164
127cornea development in camera-type eye (GO:0061303)2.32105590
128regulation of non-canonical Wnt signaling pathway (GO:2000050)2.26075532
129pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.24268932
130establishment of apical/basal cell polarity (GO:0035089)2.23833151
131nonmotile primary cilium assembly (GO:0035058)2.23425145
132response to pheromone (GO:0019236)2.23176163
133retinal ganglion cell axon guidance (GO:0031290)2.22411832
134mitochondrial respiratory chain complex I assembly (GO:0032981)2.20395380
135NADH dehydrogenase complex assembly (GO:0010257)2.20395380
136mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.20395380
137pseudouridine synthesis (GO:0001522)2.19790992
138tooth mineralization (GO:0034505)2.18435180
139cell proliferation involved in metanephros development (GO:0072203)2.17699608
140negative chemotaxis (GO:0050919)2.16096295
141cell proliferation involved in kidney development (GO:0072111)2.15711089
142establishment or maintenance of monopolar cell polarity (GO:0061339)2.15240776
143establishment of monopolar cell polarity (GO:0061162)2.15240776
144establishment of protein localization to mitochondrial membrane (GO:0090151)2.13512884
145regulation of chondrocyte differentiation (GO:0032330)2.13307717
146type B pancreatic cell proliferation (GO:0044342)2.11185083
147mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.11036294
148ubiquinone biosynthetic process (GO:0006744)2.10453484
149ubiquinone metabolic process (GO:0006743)2.08297399
150cell proliferation in forebrain (GO:0021846)2.07626835
151preassembly of GPI anchor in ER membrane (GO:0016254)2.05754797
152cell-cell signaling involved in cell fate commitment (GO:0045168)2.05063746
153left/right pattern formation (GO:0060972)2.04815965
154regulation of cartilage development (GO:0061035)2.02541776
155embryonic digit morphogenesis (GO:0042733)2.02430932
156spinal cord development (GO:0021510)2.01643064
157peptidyl-histidine modification (GO:0018202)2.01193514
158regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.00525233
159maturation of 5.8S rRNA (GO:0000460)2.00377635
160regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)1.99910105
161skeletal muscle organ development (GO:0060538)1.99702834
162hindlimb morphogenesis (GO:0035137)1.98989710
163intraciliary transport (GO:0042073)1.98636610
164protein-cofactor linkage (GO:0018065)1.98536480
1654-hydroxyproline metabolic process (GO:0019471)1.96658842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.74521464
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.15054567
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.56532986
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.54490140
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.77589103
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49291830
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.48302909
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.40436926
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38326513
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.31182375
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30256925
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.29930724
13RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.26223691
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19838135
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.19772527
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.14695834
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11188030
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.05569029
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05401746
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04951148
21CLOCK_20551151_ChIP-Seq_293T_Human2.02065556
22ZNF274_21170338_ChIP-Seq_K562_Hela2.01340637
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97207488
24CJUN_26792858_Chip-Seq_BT549_Human1.95747877
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93767070
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93531326
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93531326
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.91172969
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.87398224
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82986925
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.82407850
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.81385018
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.80527763
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80399203
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.75127607
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.75127607
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71165175
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.69044089
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66748993
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.66446776
41CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.62735551
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.60954606
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60537015
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59546582
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59148726
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56112998
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55183239
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51628721
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50193501
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50047337
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.48933980
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.47908644
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.44044851
54MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.43949271
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43025462
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42869500
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42148049
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41993677
59XRN2_22483619_ChIP-Seq_HELA_Human1.39147382
60EZH2_22144423_ChIP-Seq_EOC_Human1.38722874
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36860357
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36700313
63SOX2_20726797_ChIP-Seq_SW620_Human1.36674655
64MYC_18940864_ChIP-ChIP_HL60_Human1.34800152
65SMC1_22415368_ChIP-Seq_MEFs_Mouse1.34661488
66BRD4_25478319_ChIP-Seq_HGPS_Human1.33157771
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.33040758
68TP53_18474530_ChIP-ChIP_U2OS_Human1.32232465
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31926669
70GABP_19822575_ChIP-Seq_HepG2_Human1.31533664
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31406771
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.29122481
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28981554
74TP53_23651856_ChIP-Seq_MEFs_Mouse1.25994220
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25171587
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23223749
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22999499
78P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22862943
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22118594
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22118594
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22118594
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.21628924
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20210874
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18991732
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18959942
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18889313
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18743140
88TP53_22127205_ChIP-Seq_IMR90_Human1.18518290
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18179421
90UBF1/2_26484160_Chip-Seq_HMECs_Human1.17216252
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16223886
92MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16018132
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15224469
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14666978
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14666978
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14544541
97ISL1_27105846_Chip-Seq_CPCs_Mouse1.14272382
98SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14269506
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12851311
100FOXO3_23340844_ChIP-Seq_DLD1_Human1.11955196
101FOXP1_21924763_ChIP-Seq_HESCs_Human1.11303561
102CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11192614
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11178701
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10610327
105EOMES_21245162_ChIP-Seq_HESCs_Human1.09237671
106EST1_17652178_ChIP-ChIP_JURKAT_Human1.08613801
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08515558
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08019052
109RNF2_27304074_Chip-Seq_NSC_Mouse1.07675872
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07322056
111TBX20_22328084_ChIP-Seq_HEART_Mouse1.06831468
112TBX20_22080862_ChIP-Seq_HEART_Mouse1.06831468
113IRF1_19129219_ChIP-ChIP_H3396_Human1.06638708
114ERG_21242973_ChIP-ChIP_JURKAT_Human1.06454550
115ELK3_25401928_ChIP-Seq_HUVEC_Human1.06263445
116RING1B_27294783_Chip-Seq_NPCs_Mouse1.06077708
117PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05996651
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04961131
119E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04947956
120TP63_19390658_ChIP-ChIP_HaCaT_Human1.04923414
121TTF2_22483619_ChIP-Seq_HELA_Human1.04870216
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04583864
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03120373
124SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01843518
125SA1_22415368_ChIP-Seq_MEFs_Mouse1.01748040
126SOX2_16153702_ChIP-ChIP_HESCs_Human1.01158166
127AR_21572438_ChIP-Seq_LNCaP_Human0.99780488
128GBX2_23144817_ChIP-Seq_PC3_Human0.99743078
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.98954046
130ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98946561
131ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98892617
132RACK7_27058665_Chip-Seq_MCF-7_Human0.98081416
133CTCF_27219007_Chip-Seq_Bcells_Human0.96422972
134RING1B_27294783_Chip-Seq_ESCs_Mouse0.95831856
135SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95692697
136TET1_21451524_ChIP-Seq_MESCs_Mouse0.94743812
137EWS_26573619_Chip-Seq_HEK293_Human0.93812219
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91424001
139EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91230590
140TP53_16413492_ChIP-PET_HCT116_Human0.91176801
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90246185
142NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89577064
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89031170
144ZNF263_19887448_ChIP-Seq_K562_Human0.88225237
145KLF5_25053715_ChIP-Seq_YYC3_Human0.87896590
146NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87808309
147ATF3_27146783_Chip-Seq_COLON_Human0.87765549
148DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86516204
149SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86376408
150CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85808848
151MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85380237
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.85008324
153MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84668682
154POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84536856
155NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83107322
156CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.81980166
157MYC_19030024_ChIP-ChIP_MESCs_Mouse0.81289062
158EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81063963
159CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79070759
160TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78973236
161SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.78266852
162SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78093073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.68091062
2MP0005503_abnormal_tendon_morphology4.51513654
3MP0005275_abnormal_skin_tensile4.04511351
4MP0005623_abnormal_meninges_morphology3.15815234
5MP0004272_abnormal_basement_membrane2.94805607
6MP0003279_aneurysm2.91822159
7MP0009384_cardiac_valve_regurgitation2.81885108
8MP0010030_abnormal_orbit_morphology2.71977234
9MP0003705_abnormal_hypodermis_morpholog2.51667690
10MP0001958_emphysema2.39422463
11MP0009250_abnormal_appendicular_skeleto2.29125197
12MP0005508_abnormal_skeleton_morphology2.26365698
13MP0006292_abnormal_olfactory_placode2.08155511
14MP0001299_abnormal_eye_distance/2.06684299
15MP0003283_abnormal_digestive_organ1.94314703
16MP0003385_abnormal_body_wall1.85829740
17MP0004133_heterotaxia1.83979995
18MP0003136_yellow_coat_color1.83230386
19MP0005257_abnormal_intraocular_pressure1.81263056
20MP0004134_abnormal_chest_morphology1.75505441
21MP0001542_abnormal_bone_strength1.71658289
22MP0006054_spinal_hemorrhage1.68261740
23MP0002295_abnormal_pulmonary_circulatio1.66958949
24MP0002108_abnormal_muscle_morphology1.65645288
25MP0002060_abnormal_skin_morphology1.65409776
26MP0002896_abnormal_bone_mineralization1.64653496
27MP0000013_abnormal_adipose_tissue1.64017289
28MP0000762_abnormal_tongue_morphology1.63367579
29MP0002653_abnormal_ependyma_morphology1.63018658
30MP0003950_abnormal_plasma_membrane1.62169573
31MP0000049_abnormal_middle_ear1.58674208
32MP0000163_abnormal_cartilage_morphology1.48434011
33MP0003942_abnormal_urinary_system1.47584333
34MP0000537_abnormal_urethra_morphology1.45125368
35MP0004858_abnormal_nervous_system1.44787003
36MP0000428_abnormal_craniofacial_morphol1.44453331
37MP0002282_abnormal_trachea_morphology1.42869610
38MP0003937_abnormal_limbs/digits/tail_de1.42393308
39MP0003566_abnormal_cell_adhesion1.40533100
40MP0003755_abnormal_palate_morphology1.38766979
41MP0000462_abnormal_digestive_system1.35715135
42MP0003941_abnormal_skin_development1.32044171
43MP0000751_myopathy1.31687423
44MP0000733_abnormal_muscle_development1.31345767
45MP0002877_abnormal_melanocyte_morpholog1.30684680
46MP0000538_abnormal_urinary_bladder1.29052622
47MP0008789_abnormal_olfactory_epithelium1.27891692
48MP0000534_abnormal_ureter_morphology1.27687122
49MP0003091_abnormal_cell_migration1.27319483
50MP0002249_abnormal_larynx_morphology1.26285012
51MP0001293_anophthalmia1.26252059
52MP0000003_abnormal_adipose_tissue1.24380651
53MP0002932_abnormal_joint_morphology1.24263520
54MP0000566_synostosis1.24057373
55MP0002115_abnormal_skeleton_extremities1.23991347
56MP0002160_abnormal_reproductive_system1.23902924
57MP0000920_abnormal_myelination1.23697049
58MP0002933_joint_inflammation1.23645770
59MP0001243_abnormal_dermal_layer1.22054966
60MP0001348_abnormal_lacrimal_gland1.20251437
61MP0005023_abnormal_wound_healing1.18069220
62MP0000749_muscle_degeneration1.13046761
63MP0000467_abnormal_esophagus_morphology1.11814263
64MP0002102_abnormal_ear_morphology1.10576964
65MP0005187_abnormal_penis_morphology1.09480688
66MP0002233_abnormal_nose_morphology1.09116322
67MP0002116_abnormal_craniofacial_bone1.08805238
68MP0009053_abnormal_anal_canal1.08730155
69MP0006072_abnormal_retinal_apoptosis1.07444487
70MP0002837_dystrophic_cardiac_calcinosis1.06914749
71MP0000778_abnormal_nervous_system1.06874407
72MP0001346_abnormal_lacrimal_gland1.05321379
73MP0001286_abnormal_eye_development1.04914803
74MP0002736_abnormal_nociception_after1.04534545
75MP0001529_abnormal_vocalization1.03997225
76MP0009379_abnormal_foot_pigmentation1.03467877
77MP0003122_maternal_imprinting1.03330163
78MP0000750_abnormal_muscle_regeneration1.01366094
79MP0005390_skeleton_phenotype1.00115845
80MP0002113_abnormal_skeleton_development0.98498620
81MP0000631_abnormal_neuroendocrine_gland0.97470584
82MP0009780_abnormal_chondrocyte_physiolo0.97458403
83MP0002177_abnormal_outer_ear0.96695117
84MP0000579_abnormal_nail_morphology0.96283320
85MP0002109_abnormal_limb_morphology0.96163233
86MP0000432_abnormal_head_morphology0.95400903
87MP0002111_abnormal_tail_morphology0.94008341
88MP0005171_absent_coat_pigmentation0.93951965
89MP0002092_abnormal_eye_morphology0.93408439
90MP0000747_muscle_weakness0.91949982
91MP0003935_abnormal_craniofacial_develop0.91908304
92MP0003115_abnormal_respiratory_system0.91837293
93MP0008775_abnormal_heart_ventricle0.91599856
94MP0000026_abnormal_inner_ear0.90391392
95MP0003119_abnormal_digestive_system0.89316293
96MP0005197_abnormal_uvea_morphology0.88095361
97MP0003878_abnormal_ear_physiology0.87399790
98MP0005377_hearing/vestibular/ear_phenot0.87399790
99MP0002184_abnormal_innervation0.86758401
100MP0002234_abnormal_pharynx_morphology0.86478858
101MP0000767_abnormal_smooth_muscle0.86152452
102MP0006276_abnormal_autonomic_nervous0.86000349
103MP0008932_abnormal_embryonic_tissue0.85432905
104MP0005389_reproductive_system_phenotype0.84689056
105MP0002114_abnormal_axial_skeleton0.84417926
106MP0001340_abnormal_eyelid_morphology0.84178080
107MP0000759_abnormal_skeletal_muscle0.84106246
108MP0004185_abnormal_adipocyte_glucose0.83900844
109MP0004084_abnormal_cardiac_muscle0.82767627
110MP0001968_abnormal_touch/_nociception0.79614984
111MP0005499_abnormal_olfactory_system0.79265694
112MP0005394_taste/olfaction_phenotype0.79265694
113MP0002751_abnormal_autonomic_nervous0.78499348
114MP0003861_abnormal_nervous_system0.78153788
115MP0005391_vision/eye_phenotype0.77551850
116MP0001849_ear_inflammation0.77379588
117MP0010386_abnormal_urinary_bladder0.76471101
118MP0003121_genomic_imprinting0.75923646
119MP0005195_abnormal_posterior_eye0.75517470
120MP0000383_abnormal_hair_follicle0.75062635
121MP0000647_abnormal_sebaceous_gland0.74193863
122MP0010368_abnormal_lymphatic_system0.73784105
123MP0005551_abnormal_eye_electrophysiolog0.73351950
124MP0004233_abnormal_muscle_weight0.73338746
125MP0002938_white_spotting0.73187348
126MP0005369_muscle_phenotype0.72740410
127MP0002697_abnormal_eye_size0.72052736
128MP0008875_abnormal_xenobiotic_pharmacok0.71942383
129MP0004087_abnormal_muscle_fiber0.71746405
130MP0002638_abnormal_pupillary_reflex0.71041395
131MP0001270_distended_abdomen0.70668247
132MP0003634_abnormal_glial_cell0.70612351
133MP0002168_other_aberrant_phenotype0.69836789
134MP0000516_abnormal_urinary_system0.69617773
135MP0005367_renal/urinary_system_phenotyp0.69617773
136MP0005375_adipose_tissue_phenotype0.67679707
137MP0005330_cardiomyopathy0.67305099
138MP0003795_abnormal_bone_structure0.67149254
139MP0006138_congestive_heart_failure0.66794610
140MP0000678_abnormal_parathyroid_gland0.65876372
141MP0005595_abnormal_vascular_smooth0.65626381
142MP0010771_integument_phenotype0.65193384
143MP0010678_abnormal_skin_adnexa0.65160155

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.73212964
2Protrusio acetabuli (HP:0003179)6.93205434
3Abnormality of dentin (HP:0010299)4.34142972
4Shallow orbits (HP:0000586)4.24340540
5Atrophic scars (HP:0001075)4.05062126
6Soft skin (HP:0000977)4.03012821
7Neonatal short-limb short stature (HP:0008921)3.62427127
8Aortic dissection (HP:0002647)3.60114400
9Broad metatarsal (HP:0001783)3.52148874
10Ankle contracture (HP:0006466)3.47464848
11Wormian bones (HP:0002645)3.47143310
12Peritonitis (HP:0002586)3.45956833
13Bladder diverticulum (HP:0000015)3.44399317
14Fragile skin (HP:0001030)3.40409481
15Spinal rigidity (HP:0003306)3.09258155
16Infantile muscular hypotonia (HP:0008947)2.99500597
17Cervical subluxation (HP:0003308)2.93919329
18Vertebral compression fractures (HP:0002953)2.90018603
19Blue sclerae (HP:0000592)2.89728822
20Keratoconus (HP:0000563)2.86280895
21Increased corneal curvature (HP:0100692)2.86280895
22Coronal craniosynostosis (HP:0004440)2.83470047
23Follicular hyperkeratosis (HP:0007502)2.81262330
24Cerebral aneurysm (HP:0004944)2.80976598
25Type 1 muscle fiber predominance (HP:0003803)2.80242424
26Biconcave vertebral bodies (HP:0004586)2.72114106
27Aortic aneurysm (HP:0004942)2.58814077
28Dilatation of the ascending aorta (HP:0005111)2.58459498
29Bell-shaped thorax (HP:0001591)2.58403739
30Type II lissencephaly (HP:0007260)2.55072404
31Genu recurvatum (HP:0002816)2.49493941
32Hyperextensible skin (HP:0000974)2.48633808
33Aplasia involving bones of the extremities (HP:0009825)2.48382331
34Aplasia involving bones of the upper limbs (HP:0009823)2.48382331
35Aplasia of the phalanges of the hand (HP:0009802)2.48382331
36Abnormality of midbrain morphology (HP:0002418)2.44135898
37Molar tooth sign on MRI (HP:0002419)2.44135898
38Buphthalmos (HP:0000557)2.43528581
39Pterygium (HP:0001059)2.41575166
40Muscle fiber splitting (HP:0003555)2.39834768
41Congenital stationary night blindness (HP:0007642)2.39461963
42Overgrowth (HP:0001548)2.38153508
43Epiphyseal dysplasia (HP:0002656)2.35318686
44Concave nail (HP:0001598)2.33696226
45Vascular tortuosity (HP:0004948)2.33214793
46Hypoplastic ischia (HP:0003175)2.29923463
47Coxa vara (HP:0002812)2.29823171
48Elbow flexion contracture (HP:0002987)2.29585180
49Scapular winging (HP:0003691)2.29184577
50Osteoarthritis (HP:0002758)2.28284653
51Wide anterior fontanel (HP:0000260)2.27026101
52Increased variability in muscle fiber diameter (HP:0003557)2.26848699
53Abnormal delivery (HP:0001787)2.25467417
54True hermaphroditism (HP:0010459)2.23295096
55Fibular hypoplasia (HP:0003038)2.21917112
56Pancreatic fibrosis (HP:0100732)2.20437631
57Ulnar bowing (HP:0003031)2.20151829
58Mildly elevated creatine phosphokinase (HP:0008180)2.17519657
59Femoral bowing (HP:0002980)2.17205702
60Congenital glaucoma (HP:0001087)2.16920772
61Bilateral microphthalmos (HP:0007633)2.16057632
62Increased connective tissue (HP:0009025)2.15807115
63Rib fusion (HP:0000902)2.15243006
64Pancreatic cysts (HP:0001737)2.12838934
65Abnormality of the acetabulum (HP:0003170)2.12539885
66Short nail (HP:0001799)2.11453247
67Stridor (HP:0010307)2.11298912
68Cerebellar dysplasia (HP:0007033)2.10849632
69Mitral valve prolapse (HP:0001634)2.10268974
70Aplasia/Hypoplasia of the fibula (HP:0006492)2.08877173
71Abnormality of the 2nd finger (HP:0004100)2.08736891
72Round ear (HP:0100830)2.07803320
73Bowel diverticulosis (HP:0005222)2.05637599
74Abnormality of the phalanges of the 2nd finger (HP:0009541)2.03265766
75Wrist flexion contracture (HP:0001239)2.03038895
76Abnormality of the ischium (HP:0003174)2.02244060
77Sclerocornea (HP:0000647)2.02178437
78Anophthalmia (HP:0000528)2.00669746
79Mild short stature (HP:0003502)1.99967943
80Platyspondyly (HP:0000926)1.99854099
81Mitral regurgitation (HP:0001653)1.99456561
82Short tibia (HP:0005736)1.97770644
83Occipital encephalocele (HP:0002085)1.97070595
84Aplasia/Hypoplasia of the patella (HP:0006498)1.97069727
85Cystic liver disease (HP:0006706)1.96951364
86Abnormal vertebral ossification (HP:0100569)1.96035391
87Abnormality of the proximal phalanges of the hand (HP:0009834)1.95756953
88Deviation of the hallux (HP:0010051)1.94192119
89Abnormality of the middle phalanges of the toes (HP:0010183)1.92815546
90Tibial bowing (HP:0002982)1.92771214
91Aplasia/Hypoplasia of the tibia (HP:0005772)1.92751048
92Renal duplication (HP:0000075)1.92636959
93Short hallux (HP:0010109)1.92615606
94Cupped ribs (HP:0000887)1.91401145
95Nephronophthisis (HP:0000090)1.91350236
96Patellar aplasia (HP:0006443)1.90211717
97Hallux valgus (HP:0001822)1.88082681
98Bowed forearm bones (HP:0003956)1.88080881
99Bowing of the arm (HP:0006488)1.88080881
100Abnormal number of incisors (HP:0011064)1.87278307
101Abnormality of the umbilical cord (HP:0010881)1.85814463
102Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85439184
103Thin ribs (HP:0000883)1.85244392
104Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83893641
105Arterial tortuosity (HP:0005116)1.83272666
106Abnormality of skeletal muscle fiber size (HP:0012084)1.82750655
107Premature skin wrinkling (HP:0100678)1.82328694
108Joint laxity (HP:0001388)1.81908646
109Broad ribs (HP:0000885)1.81686553
110Turricephaly (HP:0000262)1.81654612
111Breech presentation (HP:0001623)1.81078595
112Bronchomalacia (HP:0002780)1.79969110
113Tubular atrophy (HP:0000092)1.78948933
114Medial flaring of the eyebrow (HP:0010747)1.77495819
115Degeneration of the lateral corticospinal tracts (HP:0002314)1.76425389
116Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76425389
117Abnormality of the calcaneus (HP:0008364)1.75706106
118Broad long bones (HP:0005622)1.75048084
119Thin bony cortex (HP:0002753)1.73994563
120Morphological abnormality of the middle ear (HP:0008609)1.73903136
121Absent epiphyses (HP:0010577)1.73597581
122Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73597581
123Delayed cranial suture closure (HP:0000270)1.73519127
124Abnormality of the diencephalon (HP:0010662)1.73387909
125Knee flexion contracture (HP:0006380)1.72688460
126Aplasia/Hypoplasia of the hallux (HP:0008362)1.72145700
127Synostosis involving the elbow (HP:0003938)1.71108253
128Humeroradial synostosis (HP:0003041)1.71108253
129Hip contracture (HP:0003273)1.71076254
130Redundant skin (HP:0001582)1.70956290
131Fused cervical vertebrae (HP:0002949)1.70824685
132Fibular aplasia (HP:0002990)1.70668945
133Slender build (HP:0001533)1.67973942
134Distal upper limb amyotrophy (HP:0007149)1.67922858
135Upper limb amyotrophy (HP:0009129)1.67922858
136Spinal cord compression (HP:0002176)1.67841369
137Abnormal number of erythroid precursors (HP:0012131)1.67490479
138Hypoplasia of the iris (HP:0007676)1.67458492
139Severe muscular hypotonia (HP:0006829)1.65016309
140Short 4th metacarpal (HP:0010044)1.64678013
141Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64678013
142Hypoplasia of the ulna (HP:0003022)1.63167185
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.62569441
144Abnormality of the 4th metacarpal (HP:0010012)1.60589981
145Anterior segment dysgenesis (HP:0007700)1.60196479
146Delayed gross motor development (HP:0002194)1.59153650
147Bifid tongue (HP:0010297)1.58547878
148Retinal dysplasia (HP:0007973)1.57882442
149Aplasia/Hypoplasia of the ulna (HP:0006495)1.57272417
150Radial bowing (HP:0002986)1.57190533
151Slender long bone (HP:0003100)1.56494203
152Mesangial abnormality (HP:0001966)1.56167785
153Flat cornea (HP:0007720)1.51921444
154Hypoplastic pelvis (HP:0008839)1.51612803
155Mesomelia (HP:0003027)1.49900774
156Testicular atrophy (HP:0000029)1.49605394
157Median cleft lip (HP:0000161)1.47728841
158Postaxial hand polydactyly (HP:0001162)1.46398226
159Patent foramen ovale (HP:0001655)1.45500819
160Abnormality of cells of the erythroid lineage (HP:0012130)1.44432478
161Congenital primary aphakia (HP:0007707)1.43940279
162Postaxial foot polydactyly (HP:0001830)1.43747346
163Joint stiffness (HP:0001387)1.43620444
164Abnormality of the anterior chamber (HP:0000593)1.43561776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.64947366
2STK393.43379477
3TTN2.77680132
4TRIB32.76829318
5LIMK12.74715048
6MET2.56473590
7EPHB22.49509303
8PDGFRA2.29184688
9WNK42.28413256
10LATS22.20283422
11PAK32.14935519
12ZAK2.01656937
13EPHB11.99629968
14FLT31.93503009
15PAK21.84845496
16BMPR1B1.84085297
17LATS11.82383724
18GRK11.80171355
19BCR1.75280792
20FGFR21.74968898
21ADRBK21.74922344
22FER1.73004840
23FRK1.72557136
24WNK11.63128405
25OXSR11.61977142
26MAPKAPK31.61889247
27NTRK11.61576168
28TRPM71.58668508
29TESK11.58566221
30VRK21.56568942
31ROCK21.55104492
32PINK11.54849347
33TIE11.52581298
34EPHA31.49350453
35ILK1.49069239
36CASK1.46921722
37PTK21.45249517
38PKN21.42407861
39PBK1.38082987
40CDK81.38018435
41NUAK11.35972186
42TESK21.34388344
43PNCK1.24802381
44PKN11.22094909
45UHMK11.20014514
46ERN11.18812623
47PIM21.18428642
48PIK3CA1.14022078
49MUSK1.13501317
50DMPK1.13163897
51BMX1.12497526
52MAPKAPK51.11622807
53LRRK21.11055062
54PRKD11.10820010
55PRKD31.10607043
56ROCK11.10394061
57STK161.09633326
58NEK21.09592291
59MOS1.09220188
60PAK61.06404885
61CSNK1A1L1.02685788
62TGFBR11.01128707
63FGFR10.99904918
64MAP4K20.98690768
65CAMK2D0.97801889
66DAPK30.97645043
67WNK30.96054408
68TLK10.95696395
69NME20.95675852
70PTK2B0.94665929
71ICK0.94563176
72MAP3K30.89393613
73EPHA20.89235422
74MST1R0.88652936
75CDK140.88577041
76MYLK0.88514134
77INSRR0.88505772
78PIK3CG0.88384129
79CDC42BPA0.87844332
80CHEK20.87449133
81MAPK150.87402356
82PTK60.85918803
83SIK10.85444513
84PDGFRB0.85263374
85WEE10.83765176
86BRSK10.83474983
87NEK60.82968124
88PAK10.82864274
89RPS6KA20.77979185
90AURKA0.77978544
91PAK40.76969108
92PLK30.76727441
93PRKD20.76686662
94PLK20.76516685
95CDK190.75815806
96CSNK1G30.74661079
97PRKCG0.73536938
98PLK10.71323793
99MTOR0.70881459
100CAMK2B0.69911400
101ABL20.69065239
102AURKB0.68120942
103ARAF0.67489687
104PRKCI0.66922263
105CDK150.65612167
106VRK10.65532701
107MAP2K20.63730323
108LMTK20.62949352
109NME10.62678153
110KDR0.62608438
111ERBB40.61359082
112DYRK1B0.61349834
113ATR0.60961560
114PRKCE0.60431764
115CDK11A0.59482989
116CSNK1G10.58925427
117CDK180.58446595
118CDK70.57703224
119STK40.57063104
120BUB10.56998065
121NTRK20.56332197
122CAMK2G0.56059009
123MARK20.55648701
124DYRK20.55226564
125RPS6KA40.54083098
126STK30.53663903
127RPS6KA60.52700985
128MAP2K70.51566840
129INSR0.51150953
130EPHA40.50939451
131MAP2K10.50538786
132RPS6KA50.49060356
133PRKCH0.48224416
134BRSK20.47811328
135PASK0.46759230
136MARK10.45982535
137NEK10.45902706
138CSNK1G20.45828762
139STK38L0.45367812
140CSNK1A10.44885911
141TYRO30.44001943
142PHKG20.43193513
143PHKG10.43193513
144PRKAA10.43106103
145MAP3K20.42304976
146RET0.40028722
147ADRBK10.38953567
148BCKDK0.37145580
149CLK10.36920883
150OBSCN0.36769007
151CAMK2A0.35046571
152BRAF0.34706727
153PRKG20.32561982
154FGR0.32368433

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.07947453
2Protein export_Homo sapiens_hsa030603.25540581
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.04512157
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.98153357
5Sulfur relay system_Homo sapiens_hsa041222.88149619
6Protein digestion and absorption_Homo sapiens_hsa049742.63988639
7Focal adhesion_Homo sapiens_hsa045102.53791024
8Hedgehog signaling pathway_Homo sapiens_hsa043402.22910684
9Basal cell carcinoma_Homo sapiens_hsa052172.16766435
10Steroid biosynthesis_Homo sapiens_hsa001002.14396855
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.07135397
12Hippo signaling pathway_Homo sapiens_hsa043902.06125120
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.05762472
14Fatty acid elongation_Homo sapiens_hsa000622.02772704
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.99645803
16Dilated cardiomyopathy_Homo sapiens_hsa054141.95890925
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.94045251
18Proteoglycans in cancer_Homo sapiens_hsa052051.87846303
19Axon guidance_Homo sapiens_hsa043601.84193997
20Tight junction_Homo sapiens_hsa045301.83946929
21Bladder cancer_Homo sapiens_hsa052191.81906660
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.77300212
23TGF-beta signaling pathway_Homo sapiens_hsa043501.70040642
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68052982
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57214320
26Selenocompound metabolism_Homo sapiens_hsa004501.54957774
27Amoebiasis_Homo sapiens_hsa051461.52521276
28PI3K-Akt signaling pathway_Homo sapiens_hsa041511.51711829
29RNA polymerase_Homo sapiens_hsa030201.50753712
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50213210
31Sulfur metabolism_Homo sapiens_hsa009201.50190125
32Sphingolipid metabolism_Homo sapiens_hsa006001.47575057
33Vibrio cholerae infection_Homo sapiens_hsa051101.46808137
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39337169
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37890711
36Homologous recombination_Homo sapiens_hsa034401.35247746
37One carbon pool by folate_Homo sapiens_hsa006701.33660847
38Fanconi anemia pathway_Homo sapiens_hsa034601.33404074
39Wnt signaling pathway_Homo sapiens_hsa043101.33048315
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28720506
41Renal cell carcinoma_Homo sapiens_hsa052111.21746156
42Nitrogen metabolism_Homo sapiens_hsa009101.21267909
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20416372
44Malaria_Homo sapiens_hsa051441.19477391
45Nucleotide excision repair_Homo sapiens_hsa034201.18660797
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.18132518
47Pyrimidine metabolism_Homo sapiens_hsa002401.17183903
48Adherens junction_Homo sapiens_hsa045201.15232773
49Base excision repair_Homo sapiens_hsa034101.14099865
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12829965
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12273409
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11934560
53Melanogenesis_Homo sapiens_hsa049161.11758749
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11294032
55Ether lipid metabolism_Homo sapiens_hsa005651.09804905
56Melanoma_Homo sapiens_hsa052181.09410436
57MicroRNAs in cancer_Homo sapiens_hsa052061.07352473
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05648533
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01370678
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01276066
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98752899
62Oxidative phosphorylation_Homo sapiens_hsa001900.97319461
63Small cell lung cancer_Homo sapiens_hsa052220.96543333
64Cardiac muscle contraction_Homo sapiens_hsa042600.95352769
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.92749592
66Arginine and proline metabolism_Homo sapiens_hsa003300.92160680
67Ovarian steroidogenesis_Homo sapiens_hsa049130.91091592
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90383445
69Basal transcription factors_Homo sapiens_hsa030220.89920825
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88940838
71Prostate cancer_Homo sapiens_hsa052150.87807067
72Pathways in cancer_Homo sapiens_hsa052000.84753692
73Gap junction_Homo sapiens_hsa045400.83855715
74Proteasome_Homo sapiens_hsa030500.83735612
75Phototransduction_Homo sapiens_hsa047440.83384028
76Parkinsons disease_Homo sapiens_hsa050120.82408730
77Vitamin B6 metabolism_Homo sapiens_hsa007500.82308678
78Biosynthesis of amino acids_Homo sapiens_hsa012300.80453939
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79186029
80Alzheimers disease_Homo sapiens_hsa050100.78998698
81Cocaine addiction_Homo sapiens_hsa050300.78978611
82Metabolic pathways_Homo sapiens_hsa011000.78603071
83Endocytosis_Homo sapiens_hsa041440.77360983
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.77126587
85Lysosome_Homo sapiens_hsa041420.77078632
86Purine metabolism_Homo sapiens_hsa002300.76592420
87Arachidonic acid metabolism_Homo sapiens_hsa005900.76425881
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76413955
89Ribosome_Homo sapiens_hsa030100.75969763
90Ras signaling pathway_Homo sapiens_hsa040140.75537253
91Rap1 signaling pathway_Homo sapiens_hsa040150.75113519
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74548841
93DNA replication_Homo sapiens_hsa030300.73396637
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73196217
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72253855
96N-Glycan biosynthesis_Homo sapiens_hsa005100.69428990
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.67730353
98Peroxisome_Homo sapiens_hsa041460.67410138
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.67246059
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65273100
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65214328
102Phagosome_Homo sapiens_hsa041450.63006388
103RNA degradation_Homo sapiens_hsa030180.62820355
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62288277
105Mismatch repair_Homo sapiens_hsa034300.61811129
106Butanoate metabolism_Homo sapiens_hsa006500.59976537
107Pancreatic secretion_Homo sapiens_hsa049720.58380630
108Lysine degradation_Homo sapiens_hsa003100.57449930
109Fat digestion and absorption_Homo sapiens_hsa049750.57266737
110Propanoate metabolism_Homo sapiens_hsa006400.55934758
111RNA transport_Homo sapiens_hsa030130.55880610
112Galactose metabolism_Homo sapiens_hsa000520.55346897
113Linoleic acid metabolism_Homo sapiens_hsa005910.55217686
114Folate biosynthesis_Homo sapiens_hsa007900.53793036
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53594918
116Long-term depression_Homo sapiens_hsa047300.53526556
117Glutathione metabolism_Homo sapiens_hsa004800.52629154
118ErbB signaling pathway_Homo sapiens_hsa040120.52262016
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.51752848
120Fatty acid metabolism_Homo sapiens_hsa012120.51391983
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.50690910
122Pyruvate metabolism_Homo sapiens_hsa006200.50670765
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49865410
124Glioma_Homo sapiens_hsa052140.49632584
125Thyroid hormone synthesis_Homo sapiens_hsa049180.47940223
126Estrogen signaling pathway_Homo sapiens_hsa049150.46744754
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46066174
128Tryptophan metabolism_Homo sapiens_hsa003800.45523413
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45372001
130Notch signaling pathway_Homo sapiens_hsa043300.45315143
131p53 signaling pathway_Homo sapiens_hsa041150.44854127
132Chronic myeloid leukemia_Homo sapiens_hsa052200.44842309
133Serotonergic synapse_Homo sapiens_hsa047260.43099052
134Huntingtons disease_Homo sapiens_hsa050160.43094424
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42929598
136Vitamin digestion and absorption_Homo sapiens_hsa049770.42366160
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40266819
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36192997
139Shigellosis_Homo sapiens_hsa051310.35692119
140Other glycan degradation_Homo sapiens_hsa005110.35554953
141GnRH signaling pathway_Homo sapiens_hsa049120.35393669
142Platelet activation_Homo sapiens_hsa046110.32958419
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31981863
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30642805
145HTLV-I infection_Homo sapiens_hsa051660.29039706
146Viral myocarditis_Homo sapiens_hsa054160.28980264
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27417274
148Insulin secretion_Homo sapiens_hsa049110.27292437

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