P4HA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* collagen fibril organization (GO:0030199)5.34287831
2keratan sulfate catabolic process (GO:0042340)4.69439035
3glycolytic process (GO:0006096)4.59922566
4chondrocyte proliferation (GO:0035988)4.59015706
5COPII vesicle coating (GO:0048208)4.56754133
6endodermal cell differentiation (GO:0035987)4.52363063
7protein heterotrimerization (GO:0070208)4.41817158
8* peptidyl-proline hydroxylation (GO:0019511)3.98361566
9* 4-hydroxyproline metabolic process (GO:0019471)3.92167040
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.86292981
11collagen metabolic process (GO:0032963)3.79175502
12cell adhesion mediated by integrin (GO:0033627)3.76663274
13collagen catabolic process (GO:0030574)3.75251449
14basement membrane organization (GO:0071711)3.70303985
15dermatan sulfate biosynthetic process (GO:0030208)3.57560977
16chondrocyte development (GO:0002063)3.54354238
17glucose 6-phosphate metabolic process (GO:0051156)3.53738570
18multicellular organismal macromolecule metabolic process (GO:0044259)3.48760394
19negative regulation of fatty acid transport (GO:2000192)3.47434002
20craniofacial suture morphogenesis (GO:0097094)3.47177027
21* protein hydroxylation (GO:0018126)3.46189323
22cellular response to vitamin D (GO:0071305)3.45244291
23dermatan sulfate metabolic process (GO:0030205)3.39544398
24positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.39150485
25mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.39150485
26cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.38221413
27wound healing, spreading of epidermal cells (GO:0035313)3.37485837
28multicellular organismal catabolic process (GO:0044243)3.37469779
29vesicle coating (GO:0006901)3.35516024
30apoptotic cell clearance (GO:0043277)3.34499734
31neuron projection extension involved in neuron projection guidance (GO:1902284)3.34142445
32axon extension involved in axon guidance (GO:0048846)3.34142445
33cellular response to vitamin (GO:0071295)3.31433390
34retina vasculature morphogenesis in camera-type eye (GO:0061299)3.29419746
35extracellular matrix disassembly (GO:0022617)3.27850794
36bone trabecula formation (GO:0060346)3.27188149
37G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.27136781
38positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.26749622
39multicellular organismal metabolic process (GO:0044236)3.24926332
40pyruvate metabolic process (GO:0006090)3.24436059
41regulation of transforming growth factor beta2 production (GO:0032909)3.18386733
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16099725
43mesenchymal-epithelial cell signaling (GO:0060638)3.15996774
44positive regulation of endothelial cell apoptotic process (GO:2000353)3.15955725
45sequestering of extracellular ligand from receptor (GO:0035581)3.09508684
46Golgi transport vesicle coating (GO:0048200)3.08248682
47COPI coating of Golgi vesicle (GO:0048205)3.08248682
48cell migration involved in sprouting angiogenesis (GO:0002042)3.06797050
49positive regulation of mitochondrial fission (GO:0090141)3.06747721
50paraxial mesoderm development (GO:0048339)3.05643473
51negative regulation of axon guidance (GO:1902668)3.04366990
52cranial suture morphogenesis (GO:0060363)3.02931556
53skin morphogenesis (GO:0043589)3.01971519
54retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.99838426
55vascular endothelial growth factor signaling pathway (GO:0038084)2.98388297
56regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.95197663
57response to interferon-alpha (GO:0035455)2.95196216
58positive regulation by organism of defense response of other organism involved in symbiotic interact2.94902081
59modulation by symbiont of host immune response (GO:0052553)2.94902081
60positive regulation by symbiont of host defense response (GO:0052509)2.94902081
61modulation by symbiont of host defense response (GO:0052031)2.94902081
62modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.94902081
63modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.94902081
64regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.94025800
65mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.93373945
66substrate-dependent cell migration (GO:0006929)2.92820096
67cholesterol biosynthetic process (GO:0006695)2.91136103
68positive regulation of osteoblast proliferation (GO:0033690)2.90754832
69type B pancreatic cell proliferation (GO:0044342)2.86106121
70protein retention in ER lumen (GO:0006621)2.85653060
71regulation of plasminogen activation (GO:0010755)2.84833368
72negative chemotaxis (GO:0050919)2.83771284
73chondroitin sulfate biosynthetic process (GO:0030206)2.81707803
74neutrophil activation involved in immune response (GO:0002283)2.81123652
75peptidyl-glutamic acid carboxylation (GO:0017187)2.80572313
76protein carboxylation (GO:0018214)2.80572313
77facial nerve structural organization (GO:0021612)2.79065997
78endocardial cushion development (GO:0003197)2.77667656
79substrate adhesion-dependent cell spreading (GO:0034446)2.73971530
80wound healing, spreading of cells (GO:0044319)2.70031802
81lung vasculature development (GO:0060426)2.68030365
82blood vessel maturation (GO:0001955)2.67839292
83ER overload response (GO:0006983)2.67689756
84* extracellular matrix organization (GO:0030198)2.66230077
85nucleotide-sugar biosynthetic process (GO:0009226)2.65099665
86* extracellular structure organization (GO:0043062)2.64972863
87glomerular basement membrane development (GO:0032836)2.64346317
88regulation of axon guidance (GO:1902667)2.64049924
89fibril organization (GO:0097435)2.62880562
90activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.62862107
91membrane budding (GO:0006900)2.62456762
92positive regulation of blood vessel endothelial cell migration (GO:0043536)2.59977253
93embryonic foregut morphogenesis (GO:0048617)2.59506796
94UDP-N-acetylglucosamine metabolic process (GO:0006047)2.59175695
95endothelial cell morphogenesis (GO:0001886)2.58508893
96sterol biosynthetic process (GO:0016126)2.57980132
97negative regulation of chondrocyte differentiation (GO:0032331)2.56862268
98positive regulation of nuclease activity (GO:0032075)2.54591987
99negative regulation of axon extension involved in axon guidance (GO:0048843)2.53211688
100plasma lipoprotein particle assembly (GO:0034377)2.52989156
101endothelial cell proliferation (GO:0001935)2.52414179
102phagocytosis, recognition (GO:0006910)2.52111490
103mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.51334678
104negative regulation of fibrinolysis (GO:0051918)2.49463144
105very-low-density lipoprotein particle assembly (GO:0034379)2.48426564
106positive regulation of macrophage differentiation (GO:0045651)2.48253600
107positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.48025492
108cellular response to interferon-alpha (GO:0035457)2.47799997
109ER-nucleus signaling pathway (GO:0006984)2.47684148
110mesenchymal cell proliferation (GO:0010463)2.45580534
111endoplasmic reticulum unfolded protein response (GO:0030968)2.45503300
112protein N-linked glycosylation via asparagine (GO:0018279)2.45498664
113polarized epithelial cell differentiation (GO:0030859)2.44261844
114cellular copper ion homeostasis (GO:0006878)2.43340588
115peptidyl-asparagine modification (GO:0018196)2.42340353
116regulation of chemokine-mediated signaling pathway (GO:0070099)2.41315992
117establishment of tissue polarity (GO:0007164)2.40592342
118establishment of planar polarity (GO:0001736)2.40592342
119branching involved in salivary gland morphogenesis (GO:0060445)2.39929909
120muscle cell cellular homeostasis (GO:0046716)2.39274540
121negative regulation of fatty acid biosynthetic process (GO:0045717)2.39236949
122response to follicle-stimulating hormone (GO:0032354)2.37314942
123positive regulation of p38MAPK cascade (GO:1900745)2.36200690
124cellular response to unfolded protein (GO:0034620)2.35255670
125glycoprotein catabolic process (GO:0006516)2.35069263
126protein localization to cell surface (GO:0034394)2.35057116
127negative regulation of biomineral tissue development (GO:0070168)2.34987911
128regulation of chondrocyte differentiation (GO:0032330)2.34883345
129mRNA transcription (GO:0009299)2.34844039
130regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.34417256
131hyaluronan catabolic process (GO:0030214)2.34361821
132mRNA transcription from RNA polymerase II promoter (GO:0042789)2.34243876
133cochlea morphogenesis (GO:0090103)2.34152065
134regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.34067552
135regulation of cardioblast differentiation (GO:0051890)2.33996097
136negative regulation of cartilage development (GO:0061037)2.32064911
137protein N-linked glycosylation (GO:0006487)2.32042756
138negative regulation of smooth muscle cell migration (GO:0014912)2.31856117
139ER to Golgi vesicle-mediated transport (GO:0006888)2.31663725
140regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.30811585
141regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.30460279
142negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.30118568
143anterior/posterior axis specification (GO:0009948)2.29647544
144positive regulation of natural killer cell differentiation (GO:0032825)2.29353871
145negative regulation of leukocyte chemotaxis (GO:0002689)2.29232719
146face morphogenesis (GO:0060325)2.27726355
147phagocytosis, engulfment (GO:0006911)2.27265258
148keratan sulfate metabolic process (GO:0042339)2.27071283
149positive regulation of chemokine secretion (GO:0090197)2.25489515
150regulation of necroptotic process (GO:0060544)2.24878048
151regulation of SMAD protein import into nucleus (GO:0060390)2.24241860
152response to vitamin D (GO:0033280)2.24079731
153regulation of integrin-mediated signaling pathway (GO:2001044)2.23618881
154pinocytosis (GO:0006907)2.23576912
155positive regulation of metanephros development (GO:0072216)2.23417355
156regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.22718812
157pattern specification involved in kidney development (GO:0061004)2.22032886
158response to peptidoglycan (GO:0032494)2.20621083
159positive regulation of cartilage development (GO:0061036)2.20555832
160extracellular fibril organization (GO:0043206)2.20414929
161muscle cell migration (GO:0014812)2.20264906
162response to fluid shear stress (GO:0034405)2.19787123
163regulation of monocyte chemotaxis (GO:0090025)2.17299154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.63739890
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.73869163
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.20586896
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.99602493
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.77706381
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60454583
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.39466607
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.20443060
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.83506381
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.79338078
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.64072568
12RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.63979677
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.62658312
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.59291668
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.57074902
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.49456717
17PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.44902872
18* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.40959095
19CLOCK_20551151_ChIP-Seq_293T_Human2.36992694
20CJUN_26792858_Chip-Seq_BT549_Human2.29790268
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.28738787
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19354789
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17590221
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.16514461
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13014854
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.10067427
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.08329934
28* SALL4_18804426_ChIP-ChIP_XEN_Mouse2.07683220
29BRD4_25478319_ChIP-Seq_HGPS_Human2.05810410
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01132458
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.00348137
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94915275
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93477018
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92558643
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92558643
36* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87938557
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86961835
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85301150
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83043745
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.80700382
41* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.78882846
42* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.78882846
43* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76871987
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76832739
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.72378542
46UBF1/2_26484160_Chip-Seq_HMECs_Human1.71497575
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69923443
48TAF15_26573619_Chip-Seq_HEK293_Human1.67696909
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66350453
50* AR_21909140_ChIP-Seq_LNCAP_Human1.63667561
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.62945099
52* ELK3_25401928_ChIP-Seq_HUVEC_Human1.62541887
53ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.61549348
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61125165
55NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.61034354
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.56264659
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.54093280
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51555354
59SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.51477786
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50295633
61* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50164350
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.49360481
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47978853
64SOX2_20726797_ChIP-Seq_SW620_Human1.47196425
65TP53_18474530_ChIP-ChIP_U2OS_Human1.47054320
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45886307
67TFEB_21752829_ChIP-Seq_HELA_Human1.45626415
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45232786
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42794117
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41089711
71GATA1_22025678_ChIP-Seq_K562_Human1.40936007
72ZNF263_19887448_ChIP-Seq_K562_Human1.40428463
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38923686
74* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35819398
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.34796960
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33107929
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32975221
78TP53_16413492_ChIP-PET_HCT116_Human1.32385810
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32280248
80JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31047295
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29621038
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29000854
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28568469
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.27988853
85* SOX17_20123909_ChIP-Seq_XEN_Mouse1.27544492
86* PU_27001747_Chip-Seq_BMDM_Mouse1.26360609
87VDR_24763502_ChIP-Seq_THP-1_Human1.23625287
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23405138
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22799875
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.22325598
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21956438
92TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21807137
93EOMES_21245162_ChIP-Seq_HESCs_Human1.21641976
94* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.21587655
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21393906
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21380885
97SPI1_23547873_ChIP-Seq_NB4_Human1.20776534
98EWS_26573619_Chip-Seq_HEK293_Human1.19816416
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19123013
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18335389
101FUS_26573619_Chip-Seq_HEK293_Human1.17325215
102* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17133292
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16212728
104P300_19829295_ChIP-Seq_ESCs_Human1.15141992
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14267201
106VDR_24787735_ChIP-Seq_THP-1_Human1.12067537
107MYB_26560356_Chip-Seq_TH2_Human1.12038929
108* GBX2_23144817_ChIP-Seq_PC3_Human1.11880460
109SPI1_23127762_ChIP-Seq_K562_Human1.11629091
110* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10780139
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10478015
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09648294
113IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06283046
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05537070
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04631861
116* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03602215
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03298014
118NFI_21473784_ChIP-Seq_ESCs_Mouse1.03153073
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02801055
120* ELK1_19687146_ChIP-ChIP_HELA_Human1.02118004
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.01001599
122* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00737111
123PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00148960
124* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00023535
125CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00009856
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00004350
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98543504
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98445967
129SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96928698
130P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94907831
131SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93549646
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92813057
133ATF3_27146783_Chip-Seq_COLON_Human0.92770974
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92241618
135RUNX_20019798_ChIP-Seq_JUKART_Human0.92186369
136FLI1_27457419_Chip-Seq_LIVER_Mouse0.92074249
137ISL1_27105846_Chip-Seq_CPCs_Mouse0.91784863
138* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90880225
139TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89757962
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.89250159
141* MAF_26560356_Chip-Seq_TH1_Human0.89244945
142FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88812934
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88685270
144* TP53_23651856_ChIP-Seq_MEFs_Mouse0.88353984
145NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88308296
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88302011
147FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87621163
148TP53_22127205_ChIP-Seq_IMR90_Human0.86348819
149SMAD4_21799915_ChIP-Seq_A2780_Human0.86139266
150NANOG_21062744_ChIP-ChIP_HESCs_Human0.86090340
151VDR_21846776_ChIP-Seq_THP-1_Human0.85970847
152PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85759292
153GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85695932
154STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85695020
155* TBX20_22328084_ChIP-Seq_HEART_Mouse0.85028498
156* TBX20_22080862_ChIP-Seq_HEART_Mouse0.85028498
157TP53_20018659_ChIP-ChIP_R1E_Mouse0.84789301
158EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84597622
159SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84411517
160RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83092209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.26331496
2MP0005503_abnormal_tendon_morphology4.35078766
3MP0005275_abnormal_skin_tensile3.84582735
4MP0003279_aneurysm3.18326227
5MP0001958_emphysema2.91962255
6MP0005623_abnormal_meninges_morphology2.86438450
7* MP0004272_abnormal_basement_membrane2.86119235
8MP0009384_cardiac_valve_regurgitation2.83343300
9MP0003122_maternal_imprinting2.63866808
10MP0003705_abnormal_hypodermis_morpholog2.42718042
11MP0006054_spinal_hemorrhage2.40915925
12MP0005257_abnormal_intraocular_pressure2.23827538
13MP0003566_abnormal_cell_adhesion2.12123174
14MP0002933_joint_inflammation2.09707621
15MP0003950_abnormal_plasma_membrane2.05315454
16MP0005508_abnormal_skeleton_morphology1.97852445
17MP0005058_abnormal_lysosome_morphology1.80632297
18MP0001542_abnormal_bone_strength1.80290539
19MP0003091_abnormal_cell_migration1.74230786
20MP0001533_abnormal_skeleton_physiology1.67975821
21MP0005390_skeleton_phenotype1.67382180
22MP0005023_abnormal_wound_healing1.63479721
23MP0002877_abnormal_melanocyte_morpholog1.56291343
24MP0000762_abnormal_tongue_morphology1.56117470
25MP0002896_abnormal_bone_mineralization1.55955967
26MP0009250_abnormal_appendicular_skeleto1.52610592
27MP0002998_abnormal_bone_remodeling1.52557011
28MP0002938_white_spotting1.49457129
29MP0003890_abnormal_embryonic-extraembry1.49271404
30MP0003221_abnormal_cardiomyocyte_apopto1.45269897
31MP0002233_abnormal_nose_morphology1.43011792
32MP0000767_abnormal_smooth_muscle1.39304896
33MP0010368_abnormal_lymphatic_system1.37413973
34MP0002295_abnormal_pulmonary_circulatio1.35477432
35MP0005171_absent_coat_pigmentation1.34692011
36MP0004134_abnormal_chest_morphology1.33221397
37MP0002282_abnormal_trachea_morphology1.32225558
38MP0000372_irregular_coat_pigmentation1.31514218
39MP0002060_abnormal_skin_morphology1.31462911
40MP0002115_abnormal_skeleton_extremities1.31168053
41MP0000163_abnormal_cartilage_morphology1.29623691
42MP0008007_abnormal_cellular_replicative1.28902215
43MP0001299_abnormal_eye_distance/1.26126512
44MP0010352_gastrointestinal_tract_polyps1.25482556
45MP0002113_abnormal_skeleton_development1.24806405
46MP0000733_abnormal_muscle_development1.22221708
47MP0003436_decreased_susceptibility_to1.19843022
48MP0002697_abnormal_eye_size1.18033047
49MP0009780_abnormal_chondrocyte_physiolo1.17703737
50MP0003385_abnormal_body_wall1.16978387
51MP0003300_gastrointestinal_ulcer1.13424920
52MP0003795_abnormal_bone_structure1.13347917
53MP0001286_abnormal_eye_development1.12599596
54MP0002108_abnormal_muscle_morphology1.12016767
55MP0003724_increased_susceptibility_to1.10598336
56MP0001915_intracranial_hemorrhage1.09929904
57MP0003303_peritoneal_inflammation1.09567148
58MP0002092_abnormal_eye_morphology1.08273294
59MP0000343_altered_response_to1.07871806
60MP0009697_abnormal_copulation1.06395340
61MP0000428_abnormal_craniofacial_morphol1.04915251
62MP0005164_abnormal_response_to1.04890698
63MP0003448_altered_tumor_morphology1.03359332
64MP0010030_abnormal_orbit_morphology1.02233640
65MP0005197_abnormal_uvea_morphology1.01891906
66MP0005076_abnormal_cell_differentiation1.01486735
67MP0002419_abnormal_innate_immunity1.00358090
68MP0003935_abnormal_craniofacial_develop0.99829742
69MP0003828_pulmonary_edema0.99497173
70MP0010307_abnormal_tumor_latency0.98580100
71MP0003136_yellow_coat_color0.96202832
72MP0005408_hypopigmentation0.96115250
73MP0003045_fibrosis0.95206785
74MP0004808_abnormal_hematopoietic_stem0.94966361
75MP0000858_altered_metastatic_potential0.94544959
76MP0000751_myopathy0.93865184
77MP0001835_abnormal_antigen_presentation0.92807748
78MP0004858_abnormal_nervous_system0.92299446
79MP0005187_abnormal_penis_morphology0.91464240
80MP0003115_abnormal_respiratory_system0.90762885
81MP0003567_abnormal_fetal_cardiomyocyte0.90182396
82MP0003941_abnormal_skin_development0.89849825
83MP0001243_abnormal_dermal_layer0.89025355
84MP0001293_anophthalmia0.88552754
85MP0000534_abnormal_ureter_morphology0.87921599
86MP0003942_abnormal_urinary_system0.87478964
87MP0005248_abnormal_Harderian_gland0.86911941
88MP0002148_abnormal_hypersensitivity_rea0.85947510
89MP0002109_abnormal_limb_morphology0.85674751
90MP0000685_abnormal_immune_system0.84864941
91MP0004084_abnormal_cardiac_muscle0.84687004
92MP0002084_abnormal_developmental_patter0.83197346
93MP0002089_abnormal_postnatal_growth/wei0.82826143
94MP0000639_abnormal_adrenal_gland0.82213141
95MP0001175_abnormal_lung_morphology0.81713194
96MP0000749_muscle_degeneration0.81674368
97MP0003172_abnormal_lysosome_physiology0.81388685
98MP0002177_abnormal_outer_ear0.80709502
99MP0003315_abnormal_perineum_morphology0.79403771
100MP0009785_altered_susceptibility_to0.78260022
101MP0003283_abnormal_digestive_organ0.76904429
102MP0002925_abnormal_cardiovascular_devel0.76888218
103MP0002111_abnormal_tail_morphology0.76736674
104* MP0001614_abnormal_blood_vessel0.76692372
105MP0000747_muscle_weakness0.76186790
106MP0000049_abnormal_middle_ear0.75465468
107MP0000003_abnormal_adipose_tissue0.75371308
108MP0005595_abnormal_vascular_smooth0.74949871
109MP0008932_abnormal_embryonic_tissue0.74256700
110MP0005193_abnormal_anterior_eye0.73723875
111MP0002269_muscular_atrophy0.73233609
112MP0002139_abnormal_hepatobiliary_system0.72727894
113MP0000013_abnormal_adipose_tissue0.72585274
114MP0002168_other_aberrant_phenotype0.72481029
115MP0000750_abnormal_muscle_regeneration0.72302095
116MP0003121_genomic_imprinting0.71638674
117MP0002116_abnormal_craniofacial_bone0.71338819
118MP0002396_abnormal_hematopoietic_system0.70742227
119MP0004233_abnormal_muscle_weight0.69550679
120MP0002128_abnormal_blood_circulation0.69398536
121MP0000778_abnormal_nervous_system0.68544076
122* MP0003984_embryonic_growth_retardation0.67543922
123MP0005000_abnormal_immune_tolerance0.67495501
124MP0003755_abnormal_palate_morphology0.67188128
125MP0000647_abnormal_sebaceous_gland0.66673315
126MP0009333_abnormal_splenocyte_physiolog0.66655924
127MP0000432_abnormal_head_morphology0.66629596
128MP0002090_abnormal_vision0.66621810
129MP0008004_abnormal_stomach_pH0.66059859
130MP0005391_vision/eye_phenotype0.65903020
131MP0001177_atelectasis0.65097254
132MP0002932_abnormal_joint_morphology0.64644663
133MP0001879_abnormal_lymphatic_vessel0.64607357
134MP0002133_abnormal_respiratory_system0.64540749
135MP0005388_respiratory_system_phenotype0.64540749
136* MP0002088_abnormal_embryonic_growth/wei0.64342095
137MP0004264_abnormal_extraembryonic_tissu0.64052949
138MP0000465_gastrointestinal_hemorrhage0.64013522
139MP0009278_abnormal_bone_marrow0.63898019
140MP0003937_abnormal_limbs/digits/tail_de0.63842544
141MP0000490_abnormal_crypts_of0.63813977
142MP0006082_CNS_inflammation0.63585147
143MP0002114_abnormal_axial_skeleton0.63462662
144MP0005330_cardiomyopathy0.62567883
145* MP0001672_abnormal_embryogenesis/_devel0.61622779
146* MP0005380_embryogenesis_phenotype0.61622779

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.07193186
2Protrusio acetabuli (HP:0003179)6.61068792
3Cervical subluxation (HP:0003308)4.91594834
4Ankle contracture (HP:0006466)4.51518151
5Abnormal gallbladder physiology (HP:0012438)4.25883514
6Cholecystitis (HP:0001082)4.25883514
7Aortic dissection (HP:0002647)4.18310588
8Soft skin (HP:0000977)3.93161989
9Exercise-induced muscle cramps (HP:0003710)3.81366849
10Shallow orbits (HP:0000586)3.65785043
11Neonatal short-limb short stature (HP:0008921)3.64005236
12Abnormality of dentin (HP:0010299)3.62700469
13Cerebral aneurysm (HP:0004944)3.61442188
14Epiphyseal dysplasia (HP:0002656)3.60177130
15Dilatation of the ascending aorta (HP:0005111)3.50804457
16Peritonitis (HP:0002586)3.47569315
17Abnormality of glycolysis (HP:0004366)3.42254310
18Vertebral compression fractures (HP:0002953)3.41097275
19Atrophic scars (HP:0001075)3.33524548
20Wormian bones (HP:0002645)3.26443157
21Bladder diverticulum (HP:0000015)3.14016016
22Aortic aneurysm (HP:0004942)3.11924108
23Cupped ribs (HP:0000887)3.05430282
24Mitral valve prolapse (HP:0001634)2.95407528
25Increased serum pyruvate (HP:0003542)2.93634142
26Blue sclerae (HP:0000592)2.87446796
27Biconcave vertebral bodies (HP:0004586)2.86127365
28Follicular hyperkeratosis (HP:0007502)2.79709791
29Genu recurvatum (HP:0002816)2.77983171
30Radial bowing (HP:0002986)2.76125151
31Beaking of vertebral bodies (HP:0004568)2.69364577
32Fragile skin (HP:0001030)2.64993372
33Knee flexion contracture (HP:0006380)2.60786990
34Abnormality of the acetabulum (HP:0003170)2.60786495
35Broad metatarsal (HP:0001783)2.59769837
36Hypoplastic ischia (HP:0003175)2.59397888
37Elbow flexion contracture (HP:0002987)2.57015116
38Type 1 muscle fiber predominance (HP:0003803)2.55904418
39Platyspondyly (HP:0000926)2.55367864
40Vascular tortuosity (HP:0004948)2.55234274
41Osteoarthritis (HP:0002758)2.52723744
42Coronal craniosynostosis (HP:0004440)2.52563895
43Spinal rigidity (HP:0003306)2.49076376
44Pterygium (HP:0001059)2.46261718
45Coxa vara (HP:0002812)2.44567444
46Wide anterior fontanel (HP:0000260)2.41742215
47Nuclear cataract (HP:0100018)2.41416013
48Joint laxity (HP:0001388)2.39833858
49Spondylolisthesis (HP:0003302)2.35355237
50Small epiphyses (HP:0010585)2.33559774
51Short nail (HP:0001799)2.31464279
52Abnormality of the ischium (HP:0003174)2.30661503
53Osteolytic defects of the hand bones (HP:0009699)2.24156451
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.24156451
55Ulnar bowing (HP:0003031)2.24057559
56Joint stiffness (HP:0001387)2.22711257
57Arterial tortuosity (HP:0005116)2.22560106
58Spinal cord compression (HP:0002176)2.21866889
59Femoral bowing (HP:0002980)2.20885312
60Mesomelia (HP:0003027)2.13078141
61Broad ribs (HP:0000885)2.12471442
62Mitral stenosis (HP:0001718)2.10960074
63Renal duplication (HP:0000075)2.10925968
64Inguinal hernia (HP:0000023)2.10735176
65Bell-shaped thorax (HP:0001591)2.09780452
66Mild short stature (HP:0003502)2.09543617
67Hypoplasia of the odontoid process (HP:0003311)2.09323510
68Abnormal delivery (HP:0001787)2.08978265
69Wrist flexion contracture (HP:0001239)2.08252072
70Rhizomelia (HP:0008905)2.08172037
71Bowed forearm bones (HP:0003956)2.07624661
72Bowing of the arm (HP:0006488)2.07624661
73Deep venous thrombosis (HP:0002625)2.06470366
74Ovoid vertebral bodies (HP:0003300)2.06462702
75Broad palm (HP:0001169)2.05469757
76Abnormality of the odontoid process (HP:0003310)2.03256047
77Irregular epiphyses (HP:0010582)2.00794249
78Mildly elevated creatine phosphokinase (HP:0008180)1.99808350
79Abnormality of the common coagulation pathway (HP:0010990)1.99291184
80Hyperextensible skin (HP:0000974)1.99095172
81Ankyloglossia (HP:0010296)1.97779184
82Persistence of primary teeth (HP:0006335)1.97020280
83Thin ribs (HP:0000883)1.95740235
84Abnormality of the peritoneum (HP:0002585)1.94871008
85Metaphyseal cupping (HP:0003021)1.94524805
86Myoglobinuria (HP:0002913)1.93512428
87Exostoses (HP:0100777)1.92665263
88Mitral regurgitation (HP:0001653)1.91713438
89Spinal cord lesions (HP:0100561)1.91090700
90Syringomyelia (HP:0003396)1.91090700
91Slender build (HP:0001533)1.90437479
92Bifid tongue (HP:0010297)1.90001362
93Broad face (HP:0000283)1.89229745
94Flat acetabular roof (HP:0003180)1.88910589
95Morphological abnormality of the middle ear (HP:0008609)1.88424744
96Absent frontal sinuses (HP:0002688)1.87104537
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86969983
98Ectopia lentis (HP:0001083)1.86386629
99Breech presentation (HP:0001623)1.86368263
100Hip contracture (HP:0003273)1.85166950
101Abnormal vertebral ossification (HP:0100569)1.84984139
102Ulnar deviation of the wrist (HP:0003049)1.83167781
103Camptodactyly of toe (HP:0001836)1.80925220
104Broad long bones (HP:0005622)1.80672112
105Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.80362119
106Bowel diverticulosis (HP:0005222)1.80165466
107Decreased skull ossification (HP:0004331)1.79397187
108Increased connective tissue (HP:0009025)1.79320039
109Hypoplasia of the iris (HP:0007676)1.78433397
110Protruding ear (HP:0000411)1.77001693
111Vertebral arch anomaly (HP:0008438)1.74940719
112Abnormality of skull ossification (HP:0002703)1.74664966
113Vitreoretinal degeneration (HP:0000655)1.74496980
114Delayed gross motor development (HP:0002194)1.74403518
115Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74133298
116Vertebral hypoplasia (HP:0008417)1.74133298
117Aneurysm (HP:0002617)1.73513230
118Pulmonic stenosis (HP:0001642)1.72147965
119Tibial bowing (HP:0002982)1.72029748
120Craniofacial hyperostosis (HP:0004493)1.71883509
121Pectus carinatum (HP:0000768)1.71165765
122Flared iliac wings (HP:0002869)1.70844793
123Thoracolumbar scoliosis (HP:0002944)1.69734501
124Deviation of the hallux (HP:0010051)1.69703252
125Hypoalphalipoproteinemia (HP:0003233)1.69563180
126Osteopenia (HP:0000938)1.69027039
127Abnormality of carpal bone ossification (HP:0006257)1.69017037
128Abnormal ossification of hand bones (HP:0005921)1.68624814
129Abnormality of the calcaneus (HP:0008364)1.68289721
130Rhabdomyolysis (HP:0003201)1.68174475
131Limited hip movement (HP:0008800)1.68071355
132Abnormal hand bone ossification (HP:0010660)1.67367210
133Reticulocytosis (HP:0001923)1.66843518
134Cortical dysplasia (HP:0002539)1.66840230
135Aortic regurgitation (HP:0001659)1.66048490
136Papillary thyroid carcinoma (HP:0002895)1.65284087
137Abnormality of oral frenula (HP:0000190)1.63134842
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61690079
139Limb-girdle muscle weakness (HP:0003325)1.61116757
140Tetraparesis (HP:0002273)1.60607034
141Abnormality of the intrinsic pathway (HP:0010989)1.59550241
142Hammertoe (HP:0001765)1.58800681
143Zonular cataract (HP:0010920)1.58800680
144Intrahepatic cholestasis (HP:0001406)1.58202145
145Microglossia (HP:0000171)1.57477025
146Short humerus (HP:0005792)1.57159280
147Deformed tarsal bones (HP:0008119)1.56989733
148Hydroxyprolinuria (HP:0003080)1.55387887
149Abnormality of proline metabolism (HP:0010907)1.55387887
150Increased corneal curvature (HP:0100692)1.54670947
151Keratoconus (HP:0000563)1.54670947
152Myelomeningocele (HP:0002475)1.54642776
153Disproportionate tall stature (HP:0001519)1.53379568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.29800170
2FLT34.02354571
3PKN23.73105108
4TRIB33.71070458
5BCR3.23480244
6TNIK3.08467994
7TTN2.82448318
8NEK12.69026639
9EIF2AK32.50063490
10PDGFRA2.49573467
11NME22.47967048
12NLK2.35766519
13RPS6KA42.35368308
14PIM22.26389849
15KIT2.23948532
16TGFBR22.03057382
17RIPK11.89881382
18TRIM281.87861240
19CAMKK21.87260192
20TRPM71.81862056
21ERBB41.69194224
22PBK1.68788286
23ERN11.63991301
24EPHA31.57685236
25STK38L1.57300670
26WEE11.54132704
27BCKDK1.52757849
28MOS1.48345086
29EIF2AK11.46758674
30AKT31.46524600
31NEK91.46411394
32MET1.45637261
33TBK11.40653049
34JAK31.40607362
35CSF1R1.34120156
36LRRK21.32537653
37BRD41.29702414
38MAP3K41.29242622
39FER1.27781861
40PAK41.25828778
41ARAF1.25429436
42PAK21.22874035
43IKBKB1.22237815
44ERBB31.21390162
45KSR11.21241334
46MAP3K31.19119785
47BMX1.12972198
48SRPK11.12955710
49PNCK1.09259751
50IRAK41.09038504
51JAK11.08618501
52NEK21.05515019
53MYLK1.04979352
54STK31.02309598
55TEC1.01110756
56ROCK21.00994436
57TGFBR11.00877286
58PDGFRB1.00177205
59FGFR40.98232386
60EIF2AK20.98043031
61WNK40.96123176
62SCYL20.95566980
63PRKG20.94820109
64ZAP700.94571592
65STK100.94026085
66MAP3K140.93685717
67ICK0.91973265
68PTK60.88912696
69EPHA20.87247659
70TYK20.86611190
71MKNK20.85822570
72LIMK10.83997778
73KSR20.83034650
74MKNK10.80565250
75ILK0.79744524
76FGFR10.79434724
77MAP3K60.77886057
78MAP2K70.77726094
79SIK10.77232290
80PTK20.76594092
81MAP3K90.75444612
82PLK30.74802959
83MUSK0.72959581
84EEF2K0.72890252
85MAP2K30.72261036
86BMPR1B0.72038844
87EPHB20.70834859
88PLK20.70762315
89YES10.68976748
90ZAK0.68859634
91LATS10.65769953
92MST40.65743765
93CSNK1A1L0.65743521
94RAF10.65403866
95STK240.64792455
96PDK20.63738144
97DYRK30.63232779
98CASK0.60671996
99HCK0.60570246
100CDK80.60161055
101ROCK10.59794533
102PRKCE0.59106967
103MAP3K80.58398830
104MAP3K120.58246155
105FES0.55329117
106IRAK30.55108072
107MAP4K20.54744478
108LATS20.54698899
109INSR0.54216435
110MST1R0.54002477
111WNK10.53375806
112PLK40.53325439
113ABL10.53250961
114CHUK0.53030970
115CDK180.51349236
116PIK3CG0.51288010
117SIK30.50464334
118BRSK20.49970671
119PINK10.49481118
120DAPK30.48787715
121TTK0.48690839
122MAP3K20.48629205
123PRKD20.47975714
124PIM10.47570687
125CAMKK10.47244155
126STK390.46747855
127IKBKE0.46591253
128LCK0.46512744
129RET0.46377339
130CSNK1G20.45026353
131IGF1R0.43769786
132ABL20.43356426
133NTRK10.42310733
134CDK150.42062720
135EPHB10.41989003
136PAK60.41058065
137OBSCN0.40831313
138CDK140.39629600
139LYN0.39346219
140CSNK1G10.38613725
141CDK11A0.38519952
142DYRK1B0.37861875
143NUAK10.37067490
144EPHA40.36600108
145FGFR30.36307963
146BTK0.35478279
147MARK10.35061064
148CDK90.35016550
149MAP3K50.34490960
150CSK0.34233197
151IRAK10.34093771
152CSNK1G30.33806216
153DMPK0.32908386
154CDK60.32234102
155RPS6KC10.30548969
156RPS6KL10.30548969
157MAPKAPK20.30344970
158RPS6KA60.28906788
159MAP3K130.28631753
160PIK3CA0.27859779
161PAK30.26339350

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.41170497
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.10163201
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.87816924
4Steroid biosynthesis_Homo sapiens_hsa001002.86408680
5Fructose and mannose metabolism_Homo sapiens_hsa000512.54453394
6Biosynthesis of amino acids_Homo sapiens_hsa012302.35737477
7Malaria_Homo sapiens_hsa051442.31554809
8Focal adhesion_Homo sapiens_hsa045102.23255242
9Other glycan degradation_Homo sapiens_hsa005112.06119419
10Carbon metabolism_Homo sapiens_hsa012001.94725867
11Small cell lung cancer_Homo sapiens_hsa052221.90094335
12Propanoate metabolism_Homo sapiens_hsa006401.88656373
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.84388262
14Complement and coagulation cascades_Homo sapiens_hsa046101.83943662
15Amoebiasis_Homo sapiens_hsa051461.80126074
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76813112
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.67447381
18Leishmaniasis_Homo sapiens_hsa051401.66633509
19Lysosome_Homo sapiens_hsa041421.59557228
20N-Glycan biosynthesis_Homo sapiens_hsa005101.54995758
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.54776499
22Pentose phosphate pathway_Homo sapiens_hsa000301.53467798
23Toxoplasmosis_Homo sapiens_hsa051451.53106871
24Protein digestion and absorption_Homo sapiens_hsa049741.52104507
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49571939
26Proteoglycans in cancer_Homo sapiens_hsa052051.44961260
27Hedgehog signaling pathway_Homo sapiens_hsa043401.36591663
28Phagosome_Homo sapiens_hsa041451.36492112
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36200111
30TNF signaling pathway_Homo sapiens_hsa046681.34902226
31Legionellosis_Homo sapiens_hsa051341.33886102
32PI3K-Akt signaling pathway_Homo sapiens_hsa041511.32984392
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32663946
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32391054
35Osteoclast differentiation_Homo sapiens_hsa043801.29119963
36Shigellosis_Homo sapiens_hsa051311.26168238
37p53 signaling pathway_Homo sapiens_hsa041151.23655431
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23393809
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22138331
40Protein export_Homo sapiens_hsa030601.21645707
41Chronic myeloid leukemia_Homo sapiens_hsa052201.21077855
42Measles_Homo sapiens_hsa051621.19854033
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.19275483
44Adherens junction_Homo sapiens_hsa045201.19186824
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17122325
46Antigen processing and presentation_Homo sapiens_hsa046121.15072881
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14571458
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14034883
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.12559005
50Bladder cancer_Homo sapiens_hsa052191.11647369
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09666638
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08824628
53HIF-1 signaling pathway_Homo sapiens_hsa040661.08293352
54Apoptosis_Homo sapiens_hsa042101.07695512
55Pyruvate metabolism_Homo sapiens_hsa006201.07670578
56Leukocyte transendothelial migration_Homo sapiens_hsa046701.06935754
57MicroRNAs in cancer_Homo sapiens_hsa052061.06331731
58TGF-beta signaling pathway_Homo sapiens_hsa043501.06245476
59Starch and sucrose metabolism_Homo sapiens_hsa005001.05274576
60Rheumatoid arthritis_Homo sapiens_hsa053231.04903650
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04790677
62Dilated cardiomyopathy_Homo sapiens_hsa054141.04672248
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04241705
64Thyroid cancer_Homo sapiens_hsa052161.04067536
65Hepatitis B_Homo sapiens_hsa051611.03997320
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03487005
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03073057
68Pertussis_Homo sapiens_hsa051331.02222295
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99126344
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98902690
71Prostate cancer_Homo sapiens_hsa052150.98497913
72Tuberculosis_Homo sapiens_hsa051520.97541315
73Salmonella infection_Homo sapiens_hsa051320.96720414
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.93914392
75Platelet activation_Homo sapiens_hsa046110.92062026
76Axon guidance_Homo sapiens_hsa043600.91235124
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90218102
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89774613
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89152975
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88913129
81Pancreatic cancer_Homo sapiens_hsa052120.87533057
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86510214
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85909378
84Nitrogen metabolism_Homo sapiens_hsa009100.85779236
85Circadian rhythm_Homo sapiens_hsa047100.85493974
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.85290216
87HTLV-I infection_Homo sapiens_hsa051660.85044752
88Pathways in cancer_Homo sapiens_hsa052000.84558005
89Melanoma_Homo sapiens_hsa052180.84298908
90Fatty acid elongation_Homo sapiens_hsa000620.83000162
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81476281
92Hematopoietic cell lineage_Homo sapiens_hsa046400.81212982
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80070667
94Viral myocarditis_Homo sapiens_hsa054160.79996779
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79262700
96Viral carcinogenesis_Homo sapiens_hsa052030.78576934
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.77161595
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74666781
99Herpes simplex infection_Homo sapiens_hsa051680.74638534
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74381627
101Acute myeloid leukemia_Homo sapiens_hsa052210.73628118
102Hippo signaling pathway_Homo sapiens_hsa043900.73270935
103Sphingolipid metabolism_Homo sapiens_hsa006000.71703231
104Influenza A_Homo sapiens_hsa051640.71614025
105Wnt signaling pathway_Homo sapiens_hsa043100.71438174
106Glutathione metabolism_Homo sapiens_hsa004800.70461818
107Galactose metabolism_Homo sapiens_hsa000520.70350377
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70037393
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69288295
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69103509
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68840072
112Fatty acid metabolism_Homo sapiens_hsa012120.67552331
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67350885
114Thyroid hormone synthesis_Homo sapiens_hsa049180.67064074
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66779702
116Colorectal cancer_Homo sapiens_hsa052100.63330158
117Renin-angiotensin system_Homo sapiens_hsa046140.61981240
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.61046911
119Lysine degradation_Homo sapiens_hsa003100.60411944
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60034614
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59007092
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57825801
123B cell receptor signaling pathway_Homo sapiens_hsa046620.57029047
124Vibrio cholerae infection_Homo sapiens_hsa051100.56993320
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56778793
126Rap1 signaling pathway_Homo sapiens_hsa040150.55368245
127Melanogenesis_Homo sapiens_hsa049160.54332381
128One carbon pool by folate_Homo sapiens_hsa006700.53825071
129Renal cell carcinoma_Homo sapiens_hsa052110.53014728
130Tight junction_Homo sapiens_hsa045300.52178642
131Glioma_Homo sapiens_hsa052140.51895326
132Allograft rejection_Homo sapiens_hsa053300.51463130
133Chemokine signaling pathway_Homo sapiens_hsa040620.50780162
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48726156
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47900172
136Basal cell carcinoma_Homo sapiens_hsa052170.47798969
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47631211
138* Arginine and proline metabolism_Homo sapiens_hsa003300.46832363
139Prion diseases_Homo sapiens_hsa050200.45804510
140Graft-versus-host disease_Homo sapiens_hsa053320.44307331
141Peroxisome_Homo sapiens_hsa041460.42768405
142Sulfur metabolism_Homo sapiens_hsa009200.41913562
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41685005
144Cell cycle_Homo sapiens_hsa041100.41475602
145Asthma_Homo sapiens_hsa053100.40074001
146Glucagon signaling pathway_Homo sapiens_hsa049220.37423674
147RNA degradation_Homo sapiens_hsa030180.34376960
148Arginine biosynthesis_Homo sapiens_hsa002200.32972248
149PPAR signaling pathway_Homo sapiens_hsa033200.32598731
150Fatty acid degradation_Homo sapiens_hsa000710.30044201
151AMPK signaling pathway_Homo sapiens_hsa041520.29306159
152Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26891875

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