P4HA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)5.61399489
2protein retention in ER lumen (GO:0006621)5.39516204
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.38315699
4regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.48449666
5cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.45248229
6chondrocyte development (GO:0002063)4.43818694
7protein heterotrimerization (GO:0070208)4.42315651
8acrosome reaction (GO:0007340)4.35033153
9chondrocyte proliferation (GO:0035988)4.21124572
10limb bud formation (GO:0060174)4.12117033
11bone trabecula formation (GO:0060346)4.09882259
12COPI coating of Golgi vesicle (GO:0048205)4.01985538
13Golgi transport vesicle coating (GO:0048200)4.01985538
14retina vasculature morphogenesis in camera-type eye (GO:0061299)3.99089303
15* peptidyl-proline hydroxylation (GO:0019511)3.96003374
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.84684467
17sequestering of extracellular ligand from receptor (GO:0035581)3.67107146
18fusion of sperm to egg plasma membrane (GO:0007342)3.64616234
19collagen catabolic process (GO:0030574)3.60980220
20collagen metabolic process (GO:0032963)3.60798237
21COPII vesicle coating (GO:0048208)3.59293575
22cartilage condensation (GO:0001502)3.52635882
23cell aggregation (GO:0098743)3.52635882
24skin morphogenesis (GO:0043589)3.41620523
25response to pheromone (GO:0019236)3.40591716
26endodermal cell differentiation (GO:0035987)3.39505211
27multicellular organismal macromolecule metabolic process (GO:0044259)3.38640171
28basement membrane organization (GO:0071711)3.36865080
29negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.30818579
30multicellular organismal catabolic process (GO:0044243)3.30604346
31mesenchymal cell differentiation involved in renal system development (GO:2001012)3.29457686
32mesenchymal cell differentiation involved in kidney development (GO:0072161)3.29457686
33type B pancreatic cell proliferation (GO:0044342)3.25982806
34regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.25636280
35short-term memory (GO:0007614)3.23862824
36sperm motility (GO:0030317)3.22431875
37extracellular matrix disassembly (GO:0022617)3.21311196
38* protein hydroxylation (GO:0018126)3.19726746
39multicellular organismal metabolic process (GO:0044236)3.18618432
40mesenchymal-epithelial cell signaling (GO:0060638)3.18506618
41regulation of cardioblast differentiation (GO:0051890)3.17955489
42extracellular regulation of signal transduction (GO:1900115)3.15324457
43extracellular negative regulation of signal transduction (GO:1900116)3.15324457
44positive regulation of protein kinase C signaling (GO:0090037)3.12066295
45cell migration involved in heart development (GO:0060973)3.11116855
46neural crest cell development (GO:0014032)3.08856232
47actin filament depolymerization (GO:0030042)3.08002474
48plasma membrane fusion (GO:0045026)3.05628371
49substrate-dependent cell migration (GO:0006929)3.04401444
50glomerular visceral epithelial cell development (GO:0072015)3.03616805
51sperm capacitation (GO:0048240)3.00979953
52wound healing, spreading of epidermal cells (GO:0035313)3.00948737
53endothelial cell morphogenesis (GO:0001886)2.98092493
54tooth mineralization (GO:0034505)2.96317186
55negative regulation of striated muscle cell apoptotic process (GO:0010664)2.96001891
56positive regulation of cartilage development (GO:0061036)2.93655590
57glomerular basement membrane development (GO:0032836)2.93586105
58cartilage morphogenesis (GO:0060536)2.92933283
59extracellular matrix organization (GO:0030198)2.90075971
60extracellular structure organization (GO:0043062)2.88796090
61polarized epithelial cell differentiation (GO:0030859)2.88235215
62keratan sulfate catabolic process (GO:0042340)2.86590883
63extracellular fibril organization (GO:0043206)2.85885275
64regulation of plasminogen activation (GO:0010755)2.84565151
65glomerular epithelial cell development (GO:0072310)2.83273027
66negative regulation of stem cell proliferation (GO:2000647)2.83221159
67atrioventricular valve morphogenesis (GO:0003181)2.79375430
68lateral sprouting from an epithelium (GO:0060601)2.78799427
69branching involved in salivary gland morphogenesis (GO:0060445)2.78467773
70lung vasculature development (GO:0060426)2.77980729
71extracellular matrix assembly (GO:0085029)2.77854629
72peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.77819683
73kidney mesenchyme development (GO:0072074)2.76500117
74endothelial cell chemotaxis (GO:0035767)2.76158929
75hemidesmosome assembly (GO:0031581)2.76082803
76endochondral ossification (GO:0001958)2.75709473
77replacement ossification (GO:0036075)2.75709473
78cell-substrate junction assembly (GO:0007044)2.75653072
79fibril organization (GO:0097435)2.75207724
80negative regulation of chondrocyte differentiation (GO:0032331)2.75159961
81regulation of metalloenzyme activity (GO:0048552)2.73367554
82endocardial cushion development (GO:0003197)2.73048132
83mesenchymal cell proliferation (GO:0010463)2.71264231
84coenzyme catabolic process (GO:0009109)2.71049219
85regulation of extracellular matrix disassembly (GO:0010715)2.70650908
86dermatan sulfate biosynthetic process (GO:0030208)2.69364871
87cellular response to vitamin (GO:0071295)2.69252119
88cartilage development (GO:0051216)2.69015018
89cell adhesion mediated by integrin (GO:0033627)2.67923334
90apoptotic cell clearance (GO:0043277)2.67502642
91sympathetic nervous system development (GO:0048485)2.66343665
92cell migration involved in sprouting angiogenesis (GO:0002042)2.65390303
93hyaluronan catabolic process (GO:0030214)2.64587156
94mesodermal cell differentiation (GO:0048333)2.63585877
95positive regulation of osteoblast proliferation (GO:0033690)2.63359549
96sexual reproduction (GO:0019953)2.62441775
97cochlea morphogenesis (GO:0090103)2.60998860
98regulation of apoptotic process involved in morphogenesis (GO:1902337)2.60415204
99cellular response to vitamin D (GO:0071305)2.59391515
100membrane protein ectodomain proteolysis (GO:0006509)2.58905018
101binding of sperm to zona pellucida (GO:0007339)2.58764126
102smooth muscle tissue development (GO:0048745)2.57059354
103regulation of transforming growth factor beta2 production (GO:0032909)2.56695321
104establishment of tissue polarity (GO:0007164)2.56470101
105establishment of planar polarity (GO:0001736)2.56470101
106chromosome condensation (GO:0030261)2.55483878
107substrate adhesion-dependent cell spreading (GO:0034446)2.55355207
108cardiac epithelial to mesenchymal transition (GO:0060317)2.54866149
109negative regulation of cartilage development (GO:0061037)2.53740537
110embryonic skeletal joint morphogenesis (GO:0060272)2.53291177
111regulation of type B pancreatic cell apoptotic process (GO:2000674)2.52107959
112plasma membrane repair (GO:0001778)2.52027802
113regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.51441136
114UDP-N-acetylglucosamine metabolic process (GO:0006047)2.48579493
115wound healing, spreading of cells (GO:0044319)2.47456539
116regulation of cartilage development (GO:0061035)2.46446646
117metanephric mesenchyme development (GO:0072075)2.45526564
118vesicle coating (GO:0006901)2.45215219
119lung-associated mesenchyme development (GO:0060484)2.45158608
120L-serine transport (GO:0015825)2.45048245
121positive regulation of blood vessel endothelial cell migration (GO:0043536)2.44245079
122establishment of apical/basal cell polarity (GO:0035089)2.44162000
123positive regulation of chondrocyte differentiation (GO:0032332)2.44097550
124notochord development (GO:0030903)2.43415119
125response to BMP (GO:0071772)2.43244159
126cellular response to BMP stimulus (GO:0071773)2.43244159
127regulation of chondrocyte differentiation (GO:0032330)2.43242961
128mesenchymal cell development (GO:0014031)2.41228575
129response to redox state (GO:0051775)2.41051603
130embryonic cranial skeleton morphogenesis (GO:0048701)2.40851499
131desmosome organization (GO:0002934)2.40789430
132regulation of mesenchymal cell proliferation (GO:0010464)2.40745195
133DNA packaging (GO:0006323)2.40492918
134dermatan sulfate metabolic process (GO:0030205)2.40390057
135negative regulation of axon extension involved in axon guidance (GO:0048843)2.40255475
136negative regulation of embryonic development (GO:0045992)2.40106679
137negative regulation of leukocyte chemotaxis (GO:0002689)2.39814938
138venous blood vessel morphogenesis (GO:0048845)2.39643003
139positive regulation of stem cell differentiation (GO:2000738)2.39167075
140positive regulation of mesenchymal cell proliferation (GO:0002053)2.38099380
141trabecula formation (GO:0060343)2.36822334
142myoblast fusion (GO:0007520)2.36697094
143skeletal system development (GO:0001501)2.36068764
144import into cell (GO:0098657)2.36067750
145regulation of integrin-mediated signaling pathway (GO:2001044)2.34737411
146regulation of heart morphogenesis (GO:2000826)2.33991439
147negative regulation of protein localization to cell surface (GO:2000009)2.33647637
148otic vesicle formation (GO:0030916)2.33566298
149dopaminergic neuron differentiation (GO:0071542)2.33528420
150adhesion of symbiont to host cell (GO:0044650)2.32983296
151virion attachment to host cell (GO:0019062)2.32983296
152face morphogenesis (GO:0060325)2.32399249
153cardiac myofibril assembly (GO:0055003)2.32299832
154positive regulation of extracellular matrix organization (GO:1903055)2.31827465
155axon extension involved in axon guidance (GO:0048846)2.29056660
156neuron projection extension involved in neuron projection guidance (GO:1902284)2.29056660
157regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.28241256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.61145134
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.32675696
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.92070582
4EED_16625203_ChIP-ChIP_MESCs_Mouse2.88557209
5* EZH2_27304074_Chip-Seq_ESCs_Mouse2.60593150
6GBX2_23144817_ChIP-Seq_PC3_Human2.56214535
7BRD4_25478319_ChIP-Seq_HGPS_Human2.53748283
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48825249
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45427385
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45427385
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44242236
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.43852775
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.41282272
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38612795
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36153739
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28581399
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27199964
18* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22981160
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.22071203
20JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.17399836
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.06566079
22JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.97438892
23* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89616458
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.88818069
25AR_21572438_ChIP-Seq_LNCaP_Human1.86654027
26EZH2_22144423_ChIP-Seq_EOC_Human1.84484007
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.84373486
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.84373486
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83201395
30* WT1_19549856_ChIP-ChIP_CCG9911_Human1.80681435
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.80524644
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.80240886
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.79205648
34* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77925735
35CJUN_26792858_Chip-Seq_BT549_Human1.72388964
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70633221
37TP53_22127205_ChIP-Seq_IMR90_Human1.68334915
38TP53_18474530_ChIP-ChIP_U2OS_Human1.68164484
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.67347173
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.66986740
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65729640
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.65571063
43* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63191523
44* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62733712
45TP53_16413492_ChIP-PET_HCT116_Human1.62290836
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.60626939
47P63_26484246_Chip-Seq_KERATINOCYTES_Human1.59658419
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.56360798
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55349425
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49340267
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47353343
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45479127
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.43396905
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43197556
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43197556
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41675431
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41605712
58TP63_23658742_ChIP-Seq_EP156T_Human1.40524467
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.38304911
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35822821
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33580567
62* UBF1/2_26484160_Chip-Seq_HMECs_Human1.32720127
63TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.31721210
64VDR_22108803_ChIP-Seq_LS180_Human1.31159157
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.27925823
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26528020
67TP53_23651856_ChIP-Seq_MEFs_Mouse1.25629316
68* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23825731
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.22964793
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22665797
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16850458
72* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16621768
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16115155
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.15819728
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15757047
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15340365
77* ATF3_27146783_Chip-Seq_COLON_Human1.14965632
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14616814
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13889171
80* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13741793
81CSB_26484114_Chip-Seq_FIBROBLAST_Human1.13699658
82ER_23166858_ChIP-Seq_MCF-7_Human1.12611705
83* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12308200
84* SOX2_20726797_ChIP-Seq_SW620_Human1.12268665
85* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12261426
86SMAD4_21799915_ChIP-Seq_A2780_Human1.11957738
87* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.09934926
88* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09852518
89* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09716688
90DROSHA_22980978_ChIP-Seq_HELA_Human1.08925500
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08648597
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08643634
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.08307372
94P300_19829295_ChIP-Seq_ESCs_Human1.08222700
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08115336
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.07647895
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07190838
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06617769
99MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06082063
100TCF4_18268006_ChIP-ChIP_LS174T_Human1.05033115
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04964851
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04431373
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03859715
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03169835
105AHR_22903824_ChIP-Seq_MCF-7_Human1.02057612
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02035583
107* TBX20_22080862_ChIP-Seq_HEART_Mouse1.01985532
108* TBX20_22328084_ChIP-Seq_HEART_Mouse1.01985532
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.01092798
110* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00747678
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99907204
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.99781516
113ELK3_25401928_ChIP-Seq_HUVEC_Human0.98596574
114TET1_21490601_ChIP-Seq_MESCs_Mouse0.98553585
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97312915
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96817926
117FOXA2_19822575_ChIP-Seq_HepG2_Human0.96337327
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96222013
119TAF15_26573619_Chip-Seq_HEK293_Human0.96194077
120TP63_22573176_ChIP-Seq_HFKS_Human0.95726365
121PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95445434
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.95300859
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94522598
124POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94406566
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94001634
126ZNF274_21170338_ChIP-Seq_K562_Hela0.93674211
127RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93474387
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93358372
129KLF5_25053715_ChIP-Seq_YYC3_Human0.93286670
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91688354
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91484295
132POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91440582
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.91104482
134RNF2_27304074_Chip-Seq_NSC_Mouse0.91003233
135* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90277018
136SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89862972
137WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89503989
138SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87452056
139KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87449823
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87000461
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86787390
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85925179
143RUNX2_22187159_ChIP-Seq_PCA_Human0.85237549
144FUS_26573619_Chip-Seq_HEK293_Human0.84936170
145SA1_22415368_ChIP-Seq_MEFs_Mouse0.84834654
146LXR_22292898_ChIP-Seq_THP-1_Human0.84813613
147KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84517887
148SMC1_22415368_ChIP-Seq_MEFs_Mouse0.84424889
149RXR_22158963_ChIP-Seq_LIVER_Mouse0.84284640
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84259062
151CLOCK_20551151_ChIP-Seq_293T_Human0.83862736
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83324112
153SMAD4_21741376_ChIP-Seq_HESCs_Human0.82191088
154GATA4_25053715_ChIP-Seq_YYC3_Human0.80000658
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.79686175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.33542998
2MP0005503_abnormal_tendon_morphology4.63415714
3MP0005275_abnormal_skin_tensile4.00484902
4MP0004272_abnormal_basement_membrane3.47233600
5MP0009384_cardiac_valve_regurgitation3.28611329
6MP0003279_aneurysm3.06669932
7MP0005623_abnormal_meninges_morphology3.03185339
8MP0005410_abnormal_fertilization2.70227981
9MP0001958_emphysema2.58540194
10MP0009250_abnormal_appendicular_skeleto2.41622438
11MP0004134_abnormal_chest_morphology2.22343899
12MP0010368_abnormal_lymphatic_system2.21985608
13MP0000751_myopathy2.07114387
14MP0003705_abnormal_hypodermis_morpholog2.00629632
15MP0005508_abnormal_skeleton_morphology1.98395186
16MP0000762_abnormal_tongue_morphology1.80561740
17MP0004084_abnormal_cardiac_muscle1.79432342
18MP0001348_abnormal_lacrimal_gland1.75184026
19MP0002837_dystrophic_cardiac_calcinosis1.73278893
20MP0002108_abnormal_muscle_morphology1.72824085
21MP0003646_muscle_fatigue1.69096501
22MP0003385_abnormal_body_wall1.68790579
23MP0001542_abnormal_bone_strength1.67594359
24MP0002282_abnormal_trachea_morphology1.66554955
25MP0000163_abnormal_cartilage_morphology1.65605438
26MP0002295_abnormal_pulmonary_circulatio1.65216888
27MP0002896_abnormal_bone_mineralization1.62849029
28MP0005257_abnormal_intraocular_pressure1.57283522
29MP0000049_abnormal_middle_ear1.56043639
30MP0002933_joint_inflammation1.53511452
31MP0003941_abnormal_skin_development1.52784807
32MP0001299_abnormal_eye_distance/1.50829240
33MP0009053_abnormal_anal_canal1.48163656
34MP0000566_synostosis1.45238986
35MP0003937_abnormal_limbs/digits/tail_de1.43121527
36MP0002102_abnormal_ear_morphology1.41587562
37MP0002060_abnormal_skin_morphology1.39975728
38MP0002249_abnormal_larynx_morphology1.39033008
39MP0003755_abnormal_palate_morphology1.37722841
40MP0010030_abnormal_orbit_morphology1.33734263
41MP0002115_abnormal_skeleton_extremities1.33212290
42MP0003950_abnormal_plasma_membrane1.31755555
43MP0003122_maternal_imprinting1.31619660
44MP0006138_congestive_heart_failure1.29034639
45MP0003942_abnormal_urinary_system1.27333513
46MP0008775_abnormal_heart_ventricle1.26000896
47MP0005171_absent_coat_pigmentation1.24419912
48MP0000013_abnormal_adipose_tissue1.24023802
49MP0003566_abnormal_cell_adhesion1.23244852
50MP0005360_urolithiasis1.17906424
51MP0000534_abnormal_ureter_morphology1.15943267
52MP0004484_altered_response_of1.15118062
53MP0001879_abnormal_lymphatic_vessel1.13934171
54MP0000678_abnormal_parathyroid_gland1.11955740
55MP0004858_abnormal_nervous_system1.10391638
56MP0004036_abnormal_muscle_relaxation1.09219230
57MP0002113_abnormal_skeleton_development1.09114136
58MP0002116_abnormal_craniofacial_bone1.07939941
59MP0003283_abnormal_digestive_organ1.07130742
60MP0000462_abnormal_digestive_system1.06459324
61MP0005595_abnormal_vascular_smooth1.06381715
62MP0004233_abnormal_muscle_weight1.05834553
63MP0000749_muscle_degeneration1.05512809
64MP0003091_abnormal_cell_migration1.04338662
65MP0002109_abnormal_limb_morphology1.04113247
66MP0005390_skeleton_phenotype1.03770645
67MP0000750_abnormal_muscle_regeneration1.02308511
68MP0009780_abnormal_chondrocyte_physiolo1.01659080
69MP0006054_spinal_hemorrhage1.00652664
70MP0009840_abnormal_foam_cell1.00649091
71MP0002233_abnormal_nose_morphology0.99940494
72MP0000432_abnormal_head_morphology0.98947659
73MP0005620_abnormal_muscle_contractility0.95194585
74MP0000759_abnormal_skeletal_muscle0.94873009
75MP0005369_muscle_phenotype0.92932944
76MP0003045_fibrosis0.92428687
77MP0000767_abnormal_smooth_muscle0.90685840
78MP0003935_abnormal_craniofacial_develop0.90216447
79MP0000428_abnormal_craniofacial_morphol0.88799044
80MP0002972_abnormal_cardiac_muscle0.88332115
81MP0010386_abnormal_urinary_bladder0.87500686
82MP0004145_abnormal_muscle_electrophysio0.87457082
83MP0001188_hyperpigmentation0.86539401
84MP0002932_abnormal_joint_morphology0.85366286
85MP0002234_abnormal_pharynx_morphology0.84974424
86MP0008004_abnormal_stomach_pH0.84781642
87MP0001849_ear_inflammation0.84037356
88MP0000538_abnormal_urinary_bladder0.83039146
89MP0005164_abnormal_response_to0.82303083
90MP0000467_abnormal_esophagus_morphology0.80275842
91MP0004215_abnormal_myocardial_fiber0.80163951
92MP0005023_abnormal_wound_healing0.79240800
93MP0005408_hypopigmentation0.78473432
94MP0010352_gastrointestinal_tract_polyps0.76478677
95MP0002254_reproductive_system_inflammat0.74340394
96MP0005670_abnormal_white_adipose0.73336092
97MP0002111_abnormal_tail_morphology0.72587814
98MP0000733_abnormal_muscle_development0.72323252
99MP0000003_abnormal_adipose_tissue0.72151069
100MP0002114_abnormal_axial_skeleton0.71943766
101MP0002106_abnormal_muscle_physiology0.70920000
102MP0002168_other_aberrant_phenotype0.69714452
103MP0000537_abnormal_urethra_morphology0.69614567
104MP0001614_abnormal_blood_vessel0.69111827
105MP0002269_muscular_atrophy0.68837571
106MP0002877_abnormal_melanocyte_morpholog0.68359429
107MP0002998_abnormal_bone_remodeling0.68128170
108MP0005330_cardiomyopathy0.67883518
109MP0004085_abnormal_heartbeat0.67526946
110MP0001270_distended_abdomen0.66970304
111MP0001243_abnormal_dermal_layer0.66402723
112MP0006072_abnormal_retinal_apoptosis0.65804996
113MP0004087_abnormal_muscle_fiber0.65699474
114MP0005165_increased_susceptibility_to0.65481438
115MP0005197_abnormal_uvea_morphology0.65476210
116MP0000383_abnormal_hair_follicle0.65286223
117MP0003878_abnormal_ear_physiology0.64086091
118MP0005377_hearing/vestibular/ear_phenot0.64086091
119MP0003137_abnormal_impulse_conducting0.63969924
120MP0003115_abnormal_respiratory_system0.63919687
121MP0002751_abnormal_autonomic_nervous0.63442116
122MP0010771_integument_phenotype0.63109931
123MP0005395_other_phenotype0.62753038
124MP0003191_abnormal_cellular_cholesterol0.61772344
125MP0004510_myositis0.61280110
126MP0003011_delayed_dark_adaptation0.58580041
127MP0000681_abnormal_thyroid_gland0.57685797
128MP0002128_abnormal_blood_circulation0.57120965
129MP0000747_muscle_weakness0.52825829
130MP0001915_intracranial_hemorrhage0.52008200
131MP0002177_abnormal_outer_ear0.50244481
132MP0005193_abnormal_anterior_eye0.49965501
133MP0001175_abnormal_lung_morphology0.49066929

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.60419222
2Protrusio acetabuli (HP:0003179)5.39114355
3Epiphyseal dysplasia (HP:0002656)4.58941737
4Neonatal short-limb short stature (HP:0008921)4.15136908
5Hypoplastic ischia (HP:0003175)4.02643085
6Atrophic scars (HP:0001075)3.75036824
7Abnormality of dentin (HP:0010299)3.74480289
8Abnormality of the ischium (HP:0003174)3.58941579
9Small epiphyses (HP:0010585)3.55293226
10Soft skin (HP:0000977)3.42061770
11Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.36644422
12Cupped ribs (HP:0000887)3.35226078
13Irregular epiphyses (HP:0010582)3.26764060
14Aortic dissection (HP:0002647)3.21702652
15Shallow orbits (HP:0000586)3.07116463
16Wormian bones (HP:0002645)3.05666506
17Osteoarthritis (HP:0002758)3.00725431
18Cervical subluxation (HP:0003308)2.97314504
19Popliteal pterygium (HP:0009756)2.96772126
20Follicular hyperkeratosis (HP:0007502)2.92512073
21Type 1 muscle fiber predominance (HP:0003803)2.88777492
22Spondylolisthesis (HP:0003302)2.87231201
23Fragile skin (HP:0001030)2.83722151
24Vitreoretinal degeneration (HP:0000655)2.83080076
25Mitral stenosis (HP:0001718)2.80798235
26Limited hip movement (HP:0008800)2.75355934
27Spinal cord compression (HP:0002176)2.73985083
28Mild short stature (HP:0003502)2.73783130
29Ankle contracture (HP:0006466)2.73247380
30Spinal rigidity (HP:0003306)2.72108723
31Bladder diverticulum (HP:0000015)2.68653531
32Cardiovascular calcification (HP:0011915)2.66736630
33Coxa vara (HP:0002812)2.64573324
34Bell-shaped thorax (HP:0001591)2.64086026
35Delayed epiphyseal ossification (HP:0002663)2.64022935
36Genu varum (HP:0002970)2.62879599
37Broad metatarsal (HP:0001783)2.62571395
38Hip contracture (HP:0003273)2.50730605
39Flat capital femoral epiphysis (HP:0003370)2.50566180
40Short nail (HP:0001799)2.49955591
41Metaphyseal cupping (HP:0003021)2.49242791
42Dilatation of the ascending aorta (HP:0005111)2.49120437
43Abnormal tarsal ossification (HP:0008369)2.46396928
44Femoral bowing (HP:0002980)2.45444527
45Platyspondyly (HP:0000926)2.43447873
46Abnormal vertebral ossification (HP:0100569)2.43071476
47Genu recurvatum (HP:0002816)2.42432843
48Peritonitis (HP:0002586)2.41369987
49Cerebral aneurysm (HP:0004944)2.41338014
50Blue sclerae (HP:0000592)2.40790101
51Muscle fiber splitting (HP:0003555)2.40001447
52Metaphyseal dysplasia (HP:0100255)2.39823197
53Natal tooth (HP:0000695)2.38513020
54Vascular tortuosity (HP:0004948)2.33015586
55Flat acetabular roof (HP:0003180)2.32169157
56Aplasia involving bones of the upper limbs (HP:0009823)2.30536577
57Aplasia of the phalanges of the hand (HP:0009802)2.30536577
58Aplasia involving bones of the extremities (HP:0009825)2.30536577
59Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.28683025
60Abnormality of femoral epiphyses (HP:0006499)2.28683025
61Upper limb amyotrophy (HP:0009129)2.28480532
62Distal upper limb amyotrophy (HP:0007149)2.28480532
63Bowel diverticulosis (HP:0005222)2.28253955
64Aortic aneurysm (HP:0004942)2.27262709
65Hand muscle atrophy (HP:0009130)2.24012666
66Broad ribs (HP:0000885)2.23499852
67Mitral valve prolapse (HP:0001634)2.22380386
68Ectopia lentis (HP:0001083)2.21840314
69Abnormality of the vertebral endplates (HP:0005106)2.20644240
70Aortic regurgitation (HP:0001659)2.19843066
71Morphological abnormality of the middle ear (HP:0008609)2.19425872
72Abnormality of carpal bone ossification (HP:0006257)2.17702481
73Vertebral compression fractures (HP:0002953)2.15814641
74Osteolytic defects of the hand bones (HP:0009699)2.15502573
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.15502573
76Elbow flexion contracture (HP:0002987)2.14971201
77Upper limb muscle weakness (HP:0003484)2.14456663
78Tibial bowing (HP:0002982)2.13187253
79Arterial tortuosity (HP:0005116)2.11609850
80Ulnar bowing (HP:0003031)2.11319932
81Abnormality of the phalanges of the 2nd finger (HP:0009541)2.10064617
82Mesomelia (HP:0003027)2.09133309
83Round ear (HP:0100830)2.08483477
84Abnormality of the epiphysis of the femoral head (HP:0010574)2.05888757
85Abnormality of the acetabulum (HP:0003170)2.05575329
86Wrist flexion contracture (HP:0001239)2.05128645
87Asymmetric septal hypertrophy (HP:0001670)2.04671420
88Right ventricular cardiomyopathy (HP:0011663)2.04284109
89Limited elbow extension (HP:0001377)2.03605957
90Hyperextensible skin (HP:0000974)2.03117787
91Mixed hearing impairment (HP:0000410)2.02148622
92Increased connective tissue (HP:0009025)2.02087180
93Ovoid vertebral bodies (HP:0003300)2.00991178
94Increased corneal curvature (HP:0100692)1.99950239
95Keratoconus (HP:0000563)1.99950239
96Hypoventilation (HP:0002791)1.99652363
97Abnormality of the neuromuscular junction (HP:0003398)1.99410327
98Fatigable weakness (HP:0003473)1.99410327
99Infantile muscular hypotonia (HP:0008947)1.99337679
100Aneurysm (HP:0002617)1.98633896
101Delayed gross motor development (HP:0002194)1.98242113
102Hypoplasia of the iris (HP:0007676)1.98148785
103Wide anterior fontanel (HP:0000260)1.98111604
104Abnormality of the middle phalanges of the toes (HP:0010183)1.97731640
105Mildly elevated creatine phosphokinase (HP:0008180)1.97455574
106Thin ribs (HP:0000883)1.97300428
107Distal lower limb muscle weakness (HP:0009053)1.95706850
108Overgrowth (HP:0001548)1.95610141
109Flattened epiphyses (HP:0003071)1.94113896
110Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93913165
111Absent epiphyses (HP:0010577)1.93913165
112Knee flexion contracture (HP:0006380)1.93065971
113Joint laxity (HP:0001388)1.92506418
114Beaking of vertebral bodies (HP:0004568)1.91896121
115Abnormal delivery (HP:0001787)1.91846289
116Abnormality of the 2nd finger (HP:0004100)1.91384791
117Biconcave vertebral bodies (HP:0004586)1.90056536
118Abnormality of the pubic bones (HP:0003172)1.89240618
119Pterygium (HP:0001059)1.88664504
120Slender build (HP:0001533)1.87858827
121Bradycardia (HP:0001662)1.87219577
122Abnormality of the femoral head (HP:0003368)1.86776201
123Abnormal foot bone ossification (HP:0010675)1.86383937
124Joint stiffness (HP:0001387)1.86334862
125Increased variability in muscle fiber diameter (HP:0003557)1.86243607
126Inguinal hernia (HP:0000023)1.86173662
127Short femoral neck (HP:0100864)1.85782310
128Severe visual impairment (HP:0001141)1.85142568
129Abnormal hand bone ossification (HP:0010660)1.85043867
130Vascular calcification (HP:0004934)1.84426716
131Irregular vertebral endplates (HP:0003301)1.83412215
132Unilateral renal agenesis (HP:0000122)1.83141120
133Generalized amyotrophy (HP:0003700)1.81385099
134Abnormality of the anterior chamber (HP:0000593)1.78505338
135Aplasia of the musculature (HP:0100854)1.77782818
136Aortic valve stenosis (HP:0001650)1.76509614
137Congenital glaucoma (HP:0001087)1.75773868
138Abnormality of placental membranes (HP:0011409)1.73887154
139Amniotic constriction ring (HP:0009775)1.73887154
140Mitral regurgitation (HP:0001653)1.73842947
141Protruding ear (HP:0000411)1.72156452
142Breech presentation (HP:0001623)1.71831696
143Venous insufficiency (HP:0005293)1.69564767
144Nonimmune hydrops fetalis (HP:0001790)1.68607102
145Hypoalphalipoproteinemia (HP:0003233)1.66845223
146Thin bony cortex (HP:0002753)1.64650867
147Absent frontal sinuses (HP:0002688)1.63105094
148Recurrent corneal erosions (HP:0000495)1.62863180
149Thin skin (HP:0000963)1.60657152
150Venous abnormality (HP:0002624)1.60631590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.32322749
2TESK14.13888619
3LATS22.69557715
4TTN2.65933151
5STK38L2.63549015
6EPHB22.47452662
7STK382.43184900
8CASK2.34539733
9LATS12.29135266
10FER2.25749634
11BLK2.23256822
12PDGFRA2.21454433
13EPHA22.18369090
14MET2.17344022
15EPHA32.10269329
16STK392.05307874
17PAK31.93583175
18PTK21.91284479
19LMTK21.89854024
20NME11.83493424
21PAK41.79829280
22INSRR1.71093510
23PIK3CA1.68393692
24TGFBR21.64764413
25NTRK11.62157234
26ROCK11.51068735
27MAP3K31.46513499
28DMPK1.41169401
29PLK21.39910762
30NEK91.38790710
31MYLK1.38166317
32SIK11.37914754
33TRPM71.36316618
34ROCK21.35926595
35WNK41.35029974
36RIPK11.31302963
37MAP3K121.30904592
38EPHB11.27267202
39PAK21.22903296
40PKN11.21105246
41OBSCN1.19351563
42ERN11.18822009
43PDGFRB1.16395423
44PRKD31.13711690
45PRKCE1.11557240
46PIM21.09841077
47STK241.09491966
48LIMK11.06557983
49PTK2B1.05379864
50PIK3CG1.04212228
51PNCK1.00180826
52FGFR10.99668204
53STK30.98722622
54NEK60.98575498
55CAMK2D0.98026666
56ICK0.97600143
57CDC42BPA0.97004032
58IRAK30.95140756
59NUAK10.94929116
60PHKG20.94710369
61PHKG10.94710369
62FRK0.93441992
63MAPKAPK30.93055461
64CAMK1G0.91267321
65PLK40.90860221
66PAK60.89696684
67ABL20.87344443
68MAP2K10.86163164
69OXSR10.85868060
70BCR0.85562416
71FGR0.84747186
72MAP4K20.81790548
73TRIB30.79556457
74PBK0.78985488
75MOS0.78931690
76CAMK2A0.78911780
77MAPKAPK50.78895150
78MAP3K20.78488031
79MAP3K90.77065101
80PRKD10.76186152
81MUSK0.73791457
82WNK10.73229555
83PDK20.72115845
84FGFR20.69703128
85MKNK20.67703399
86BMPR1B0.66208666
87CAMK1D0.63603006
88ADRBK10.62718965
89EIF2AK20.62082772
90FGFR40.62070771
91CDK80.61033626
92BMX0.60182450
93INSR0.60091175
94CAMK2B0.59762613
95PDPK10.59280397
96MAP3K130.58786610
97GRK10.58715184
98RPS6KA20.58489746
99PKN20.54605833
100ARAF0.54318507
101MST1R0.52931928
102NTRK30.52283900
103MKNK10.52083316
104MELK0.49117169
105CDK70.48060982
106ERBB40.47658398
107CAMK10.47011307
108TGFBR10.45520756
109TIE10.45297961
110ILK0.45053712
111PRKG10.43771684
112CDK120.43497457
113EPHA40.42620610
114RET0.42153235
115PRKAA20.41992661
116GRK70.41882168
117DYRK20.41500146
118DAPK30.41307579
119AKT30.40576320
120MAPK120.40123178
121FLT30.39568217
122MAPK110.39332154
123PRKACA0.38958723
124PRKD20.37233939
125EIF2AK10.36761073
126DYRK1A0.35562925
127CAMK2G0.35213557
128MTOR0.33808369
129SRC0.33451974
130PRKG20.33213707
131IGF1R0.30837693
132NEK20.30803095
133GSK3A0.30721760
134KSR20.29026314
135PAK10.28428218
136MAP3K80.28233586
137NEK10.25246446
138MAPKAPK20.24595310
139MAPK150.22147289

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.81628492
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.80934911
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.78898265
4Protein digestion and absorption_Homo sapiens_hsa049742.71656780
5Dilated cardiomyopathy_Homo sapiens_hsa054142.68046150
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.66513944
7Focal adhesion_Homo sapiens_hsa045102.59662427
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.54254049
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09847075
10N-Glycan biosynthesis_Homo sapiens_hsa005101.84109054
11Cardiac muscle contraction_Homo sapiens_hsa042601.70880410
12Sphingolipid metabolism_Homo sapiens_hsa006001.66861466
13PI3K-Akt signaling pathway_Homo sapiens_hsa041511.66629600
14Axon guidance_Homo sapiens_hsa043601.60985418
15Amoebiasis_Homo sapiens_hsa051461.60587391
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59879562
17Hedgehog signaling pathway_Homo sapiens_hsa043401.58578638
18Complement and coagulation cascades_Homo sapiens_hsa046101.56085357
19Melanoma_Homo sapiens_hsa052181.49271378
20Malaria_Homo sapiens_hsa051441.48673159
21Galactose metabolism_Homo sapiens_hsa000521.47051022
22Basal cell carcinoma_Homo sapiens_hsa052171.43947753
23Hippo signaling pathway_Homo sapiens_hsa043901.42794353
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38204139
25Vibrio cholerae infection_Homo sapiens_hsa051101.36854628
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36079166
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35950108
28Nicotine addiction_Homo sapiens_hsa050331.35726885
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32795242
30TGF-beta signaling pathway_Homo sapiens_hsa043501.32527676
31Proteoglycans in cancer_Homo sapiens_hsa052051.28937114
32Sulfur metabolism_Homo sapiens_hsa009201.26846928
33Oxidative phosphorylation_Homo sapiens_hsa001901.24787107
34Adherens junction_Homo sapiens_hsa045201.15433473
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.15289434
36Fructose and mannose metabolism_Homo sapiens_hsa000511.15225619
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14753006
38Ovarian steroidogenesis_Homo sapiens_hsa049131.12785471
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12569056
40Serotonergic synapse_Homo sapiens_hsa047261.09056287
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08287449
42Tight junction_Homo sapiens_hsa045301.06165940
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06160370
44Arachidonic acid metabolism_Homo sapiens_hsa005901.06077570
45Small cell lung cancer_Homo sapiens_hsa052221.04262412
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03941240
47Phagosome_Homo sapiens_hsa041451.02036770
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01731476
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01182659
50Renal cell carcinoma_Homo sapiens_hsa052110.99981792
51Glutathione metabolism_Homo sapiens_hsa004800.98046420
52Wnt signaling pathway_Homo sapiens_hsa043100.97680614
53Rap1 signaling pathway_Homo sapiens_hsa040150.97280469
54Taste transduction_Homo sapiens_hsa047420.96440505
55Bladder cancer_Homo sapiens_hsa052190.96299424
56Steroid biosynthesis_Homo sapiens_hsa001000.94972434
57Renin-angiotensin system_Homo sapiens_hsa046140.94801905
58Selenocompound metabolism_Homo sapiens_hsa004500.94642869
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94535103
60Melanogenesis_Homo sapiens_hsa049160.94451645
61Fatty acid biosynthesis_Homo sapiens_hsa000610.93872049
62Ras signaling pathway_Homo sapiens_hsa040140.93335355
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93169121
64Salivary secretion_Homo sapiens_hsa049700.92179100
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91358504
66Oxytocin signaling pathway_Homo sapiens_hsa049210.86773025
67Alzheimers disease_Homo sapiens_hsa050100.86381070
68Rheumatoid arthritis_Homo sapiens_hsa053230.85736630
69Calcium signaling pathway_Homo sapiens_hsa040200.85260110
70Protein export_Homo sapiens_hsa030600.84969764
71Long-term depression_Homo sapiens_hsa047300.84692871
72Vitamin B6 metabolism_Homo sapiens_hsa007500.83708338
73Starch and sucrose metabolism_Homo sapiens_hsa005000.81852282
74Butanoate metabolism_Homo sapiens_hsa006500.81705460
75MicroRNAs in cancer_Homo sapiens_hsa052060.81368207
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80406696
77Gap junction_Homo sapiens_hsa045400.80386412
78Ether lipid metabolism_Homo sapiens_hsa005650.80114378
79Fat digestion and absorption_Homo sapiens_hsa049750.79401975
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79183385
81Pathways in cancer_Homo sapiens_hsa052000.78776436
82Renin secretion_Homo sapiens_hsa049240.76377964
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76243288
84Cocaine addiction_Homo sapiens_hsa050300.76202706
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75213155
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75154531
87Morphine addiction_Homo sapiens_hsa050320.74396573
88Arginine biosynthesis_Homo sapiens_hsa002200.69579761
89GABAergic synapse_Homo sapiens_hsa047270.68535230
90* Arginine and proline metabolism_Homo sapiens_hsa003300.68301089
91Endocytosis_Homo sapiens_hsa041440.68260770
92Circadian entrainment_Homo sapiens_hsa047130.67288175
93HIF-1 signaling pathway_Homo sapiens_hsa040660.65665569
94Fatty acid elongation_Homo sapiens_hsa000620.65283937
95Parkinsons disease_Homo sapiens_hsa050120.65123636
96Phototransduction_Homo sapiens_hsa047440.64998176
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63581781
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.63528696
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.63473195
100p53 signaling pathway_Homo sapiens_hsa041150.61707146
101Prostate cancer_Homo sapiens_hsa052150.61650211
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58616934
103Insulin secretion_Homo sapiens_hsa049110.57953183
104GnRH signaling pathway_Homo sapiens_hsa049120.57872404
105Prion diseases_Homo sapiens_hsa050200.57816746
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57614392
107Biosynthesis of amino acids_Homo sapiens_hsa012300.56950923
108Collecting duct acid secretion_Homo sapiens_hsa049660.56674098
109Mineral absorption_Homo sapiens_hsa049780.56448089
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56320922
111PPAR signaling pathway_Homo sapiens_hsa033200.55589634
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.54945492
113cAMP signaling pathway_Homo sapiens_hsa040240.54748084
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.54071207
115Glutamatergic synapse_Homo sapiens_hsa047240.53868526
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52926545
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52680553
118Thyroid hormone synthesis_Homo sapiens_hsa049180.52482904
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50534477
120MAPK signaling pathway_Homo sapiens_hsa040100.50289637
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50252880
122Cholinergic synapse_Homo sapiens_hsa047250.50123238
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50011470
124Huntingtons disease_Homo sapiens_hsa050160.49849472
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.49697989
126Pentose phosphate pathway_Homo sapiens_hsa000300.48502358
127Lysine degradation_Homo sapiens_hsa003100.48441455
128Chemical carcinogenesis_Homo sapiens_hsa052040.48348858
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48308839
130Linoleic acid metabolism_Homo sapiens_hsa005910.48066091
131Gastric acid secretion_Homo sapiens_hsa049710.47474627
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47422622
133Other glycan degradation_Homo sapiens_hsa005110.45409251
134ErbB signaling pathway_Homo sapiens_hsa040120.44642445
135Estrogen signaling pathway_Homo sapiens_hsa049150.44634032
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43703008
137Retinol metabolism_Homo sapiens_hsa008300.43492218
138Phenylalanine metabolism_Homo sapiens_hsa003600.42947596
139Tyrosine metabolism_Homo sapiens_hsa003500.41759912
140Circadian rhythm_Homo sapiens_hsa047100.41676920
141Lysosome_Homo sapiens_hsa041420.41375298
142Fatty acid degradation_Homo sapiens_hsa000710.40980401
143Pancreatic secretion_Homo sapiens_hsa049720.40681312
144Bile secretion_Homo sapiens_hsa049760.38648419
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.34572817
146Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30802012
147Glucagon signaling pathway_Homo sapiens_hsa049220.30097802
148Carbon metabolism_Homo sapiens_hsa012000.28883013
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26097441
150ABC transporters_Homo sapiens_hsa020100.25362872
151Olfactory transduction_Homo sapiens_hsa047400.24878440

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