P4HA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.03791535
2sequestering of extracellular ligand from receptor (GO:0035581)6.01748451
3bone trabecula formation (GO:0060346)5.71305218
4chondrocyte proliferation (GO:0035988)5.67083712
5chondrocyte development (GO:0002063)5.22821434
6regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.16575167
7metanephric mesenchyme development (GO:0072075)4.66601342
8neuron projection extension involved in neuron projection guidance (GO:1902284)4.59522927
9axon extension involved in axon guidance (GO:0048846)4.59522927
10extracellular regulation of signal transduction (GO:1900115)4.51230576
11extracellular negative regulation of signal transduction (GO:1900116)4.51230576
12planar cell polarity pathway involved in neural tube closure (GO:0090179)4.45819478
13protein heterotrimerization (GO:0070208)4.39531381
14response to pheromone (GO:0019236)4.38546593
15mesenchymal-epithelial cell signaling (GO:0060638)4.32640268
16regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.25432240
17kidney mesenchyme development (GO:0072074)4.22901931
18dermatan sulfate biosynthetic process (GO:0030208)4.15710788
19blood vessel maturation (GO:0001955)4.08725083
20cell adhesion mediated by integrin (GO:0033627)4.07615210
21regulation of non-canonical Wnt signaling pathway (GO:2000050)4.07133670
22craniofacial suture morphogenesis (GO:0097094)4.04519191
23regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.01978734
24dermatan sulfate metabolic process (GO:0030205)4.01880711
25cellular response to vitamin D (GO:0071305)3.91488574
26lymphangiogenesis (GO:0001946)3.90969401
27cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.85653306
28negative regulation of embryonic development (GO:0045992)3.79030591
29type B pancreatic cell proliferation (GO:0044342)3.76068850
30negative regulation of chondrocyte differentiation (GO:0032331)3.69891739
31glomerular filtration (GO:0003094)3.68886739
32convergent extension (GO:0060026)3.67461467
33endodermal cell differentiation (GO:0035987)3.66613224
34cellular response to vitamin (GO:0071295)3.61136584
35positive regulation of osteoblast proliferation (GO:0033690)3.60336090
36glomerular visceral epithelial cell development (GO:0072015)3.52076884
37pericardium development (GO:0060039)3.51833701
38negative regulation of fatty acid transport (GO:2000192)3.50807941
39G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.50035565
40lateral sprouting from an epithelium (GO:0060601)3.49619180
41protein localization to cell surface (GO:0034394)3.47440901
42cell proliferation involved in metanephros development (GO:0072203)3.45699923
43extracellular fibril organization (GO:0043206)3.39673842
44collagen metabolic process (GO:0032963)3.38862365
45collagen catabolic process (GO:0030574)3.37692561
46mesenchyme morphogenesis (GO:0072132)3.33975880
47Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.30699527
48virion attachment to host cell (GO:0019062)3.27161291
49adhesion of symbiont to host cell (GO:0044650)3.27161291
50embryonic cranial skeleton morphogenesis (GO:0048701)3.26448871
51middle ear morphogenesis (GO:0042474)3.26251747
52negative regulation of stem cell proliferation (GO:2000647)3.26090327
53regulation of establishment of planar polarity (GO:0090175)3.23295119
54outer ear morphogenesis (GO:0042473)3.22983775
55negative chemotaxis (GO:0050919)3.22865621
56regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.21437974
57cranial suture morphogenesis (GO:0060363)3.20022680
58epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.19233650
59cochlea morphogenesis (GO:0090103)3.17368403
60UDP-N-acetylglucosamine metabolic process (GO:0006047)3.16893086
61renal filtration (GO:0097205)3.16515243
62branching involved in salivary gland morphogenesis (GO:0060445)3.13766172
63ganglion development (GO:0061548)3.13747560
64multicellular organismal macromolecule metabolic process (GO:0044259)3.12444852
65negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.11644871
66skin morphogenesis (GO:0043589)3.09397826
67wound healing, spreading of epidermal cells (GO:0035313)3.09265716
68extracellular matrix assembly (GO:0085029)3.08527690
69wound healing, spreading of cells (GO:0044319)3.07015472
70positive regulation of smoothened signaling pathway (GO:0045880)3.05054207
71negative regulation of cartilage development (GO:0061037)3.04215654
72embryonic skeletal joint morphogenesis (GO:0060272)3.01519350
73chondroitin sulfate biosynthetic process (GO:0030206)3.01297425
74multicellular organismal catabolic process (GO:0044243)3.01216892
75regulation of integrin-mediated signaling pathway (GO:2001044)3.01216449
76glomerular basement membrane development (GO:0032836)2.99363472
77cardiac epithelial to mesenchymal transition (GO:0060317)2.97299492
78detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.95647573
79cartilage morphogenesis (GO:0060536)2.94237988
80epithelial to mesenchymal transition (GO:0001837)2.92985161
81camera-type eye morphogenesis (GO:0048593)2.92251679
82positive regulation of mesenchymal cell proliferation (GO:0002053)2.92094989
83glomerular epithelial cell development (GO:0072310)2.91875838
84daunorubicin metabolic process (GO:0044597)2.91793632
85polyketide metabolic process (GO:0030638)2.91793632
86doxorubicin metabolic process (GO:0044598)2.91793632
87piRNA metabolic process (GO:0034587)2.91719701
88multicellular organismal metabolic process (GO:0044236)2.91091383
89keratan sulfate catabolic process (GO:0042340)2.90677840
90cell proliferation involved in kidney development (GO:0072111)2.90620524
91regulation of mesenchymal cell proliferation (GO:0010464)2.90171471
92tooth mineralization (GO:0034505)2.89513463
93cell migration involved in heart development (GO:0060973)2.89159198
94melanin biosynthetic process (GO:0042438)2.89104682
95activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.88619801
96positive regulation of epithelial to mesenchymal transition (GO:0010718)2.87592547
97neural crest cell development (GO:0014032)2.87471491
98notochord development (GO:0030903)2.85784601
99artery development (GO:0060840)2.85220546
100negative regulation of catenin import into nucleus (GO:0035414)2.84891383
101fibril organization (GO:0097435)2.84053247
102retina vasculature morphogenesis in camera-type eye (GO:0061299)2.83602583
103extracellular matrix disassembly (GO:0022617)2.81805805
104cartilage development (GO:0051216)2.81443749
105negative regulation of keratinocyte proliferation (GO:0010839)2.81396323
106cell migration involved in sprouting angiogenesis (GO:0002042)2.81144657
107paraxial mesoderm development (GO:0048339)2.80347888
108establishment of tissue polarity (GO:0007164)2.80179449
109establishment of planar polarity (GO:0001736)2.80179449
110chondroitin sulfate catabolic process (GO:0030207)2.80171402
111negative regulation of axon extension involved in axon guidance (GO:0048843)2.79555803
112positive regulation of cartilage development (GO:0061036)2.79251228
113mesenchymal cell development (GO:0014031)2.78918631
114positive regulation of endothelial cell apoptotic process (GO:2000353)2.77578024
115vascular endothelial growth factor signaling pathway (GO:0038084)2.77436053
116face morphogenesis (GO:0060325)2.77321567
117regulation of cartilage development (GO:0061035)2.77183029
118negative regulation of axon guidance (GO:1902668)2.77129457
119smooth muscle tissue development (GO:0048745)2.76339332
120embryonic forelimb morphogenesis (GO:0035115)2.75213599
121regulation of chondrocyte differentiation (GO:0032330)2.74267265
122negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.73155390
123decidualization (GO:0046697)2.72990985
124substrate-dependent cell migration (GO:0006929)2.72210282
125mesenchyme development (GO:0060485)2.71536748
126substrate adhesion-dependent cell spreading (GO:0034446)2.71091222
127non-canonical Wnt signaling pathway (GO:0035567)2.70566197
128hippo signaling (GO:0035329)2.70299972
129negative regulation of BMP signaling pathway (GO:0030514)2.68829461
130lung vasculature development (GO:0060426)2.68606291
131extracellular matrix organization (GO:0030198)2.66495184
132adhesion of symbiont to host (GO:0044406)2.65492563
133extracellular structure organization (GO:0043062)2.65262250
134embryonic skeletal system development (GO:0048706)2.64825355
135mesenchymal cell proliferation (GO:0010463)2.63578417
136secondary metabolite biosynthetic process (GO:0044550)2.63349095
137platelet-derived growth factor receptor signaling pathway (GO:0048008)2.63218914
138regulation of type B pancreatic cell apoptotic process (GO:2000674)2.58489859
139platelet dense granule organization (GO:0060155)2.55839324
140positive regulation of receptor internalization (GO:0002092)2.53948220
141* peptidyl-proline hydroxylation (GO:0019511)2.53840741
142inner ear receptor stereocilium organization (GO:0060122)2.52273681
143keratan sulfate metabolic process (GO:0042339)2.49653125
144regulation of hippo signaling (GO:0035330)2.49456980
145limb bud formation (GO:0060174)2.48933083
146endothelial cell proliferation (GO:0001935)2.46658969
147cellular response to amino acid stimulus (GO:0071230)2.44806246
148response to redox state (GO:0051775)2.42557769
149detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42543621
150positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.42505354
151melanin metabolic process (GO:0006582)2.38020194
152heparin metabolic process (GO:0030202)2.36852531
153heparin biosynthetic process (GO:0030210)2.36852531
154regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.35005784
155response to gravity (GO:0009629)2.34382003

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.33473387
2EZH2_22144423_ChIP-Seq_EOC_Human3.13319415
3EED_16625203_ChIP-ChIP_MESCs_Mouse3.08822389
4GBX2_23144817_ChIP-Seq_PC3_Human2.88010829
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.87511393
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.73015320
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.68772489
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.59532806
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58432951
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56149173
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52892300
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52892300
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47596248
14PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.45020263
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44895971
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44538412
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43078067
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29451454
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28032778
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27326373
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.21460417
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.15850993
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14368930
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.06973698
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.04983010
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.01416941
27TP53_18474530_ChIP-ChIP_U2OS_Human2.00670974
28ZNF274_21170338_ChIP-Seq_K562_Hela1.99696014
29JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99014182
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.98657291
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89726238
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85699059
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.85421203
34* CJUN_26792858_Chip-Seq_BT549_Human1.83670954
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78581889
36TP53_20018659_ChIP-ChIP_R1E_Mouse1.76068134
37AR_21572438_ChIP-Seq_LNCaP_Human1.73249954
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.72265100
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.71422358
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70871380
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70552701
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66996647
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.66140140
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64646553
45JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64368910
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51635967
47P300_19829295_ChIP-Seq_ESCs_Human1.50999735
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.50051221
49AHR_22903824_ChIP-Seq_MCF-7_Human1.49562008
50* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48600119
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.47767439
52* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46569301
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44126413
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44126413
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44058024
56TP53_16413492_ChIP-PET_HCT116_Human1.42903617
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.42357667
58SMAD4_21799915_ChIP-Seq_A2780_Human1.41646704
59VDR_22108803_ChIP-Seq_LS180_Human1.39281299
60BRD4_25478319_ChIP-Seq_HGPS_Human1.39210654
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39125495
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38990439
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38790370
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37297328
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.35171732
66STAT3_23295773_ChIP-Seq_U87_Human1.34614943
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34097822
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32708383
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29963460
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26533445
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26158280
72RXR_22108803_ChIP-Seq_LS180_Human1.25229816
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.24696890
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24628336
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23544706
76EWS_26573619_Chip-Seq_HEK293_Human1.22429821
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21569790
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.21414210
79TP63_23658742_ChIP-Seq_EP156T_Human1.21184986
80RNF2_27304074_Chip-Seq_NSC_Mouse1.21142043
81FUS_26573619_Chip-Seq_HEK293_Human1.19828466
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.19717398
83ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19409081
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19283425
85* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18990479
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.17938124
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17860351
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.17830569
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.17674151
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17423362
91DROSHA_22980978_ChIP-Seq_HELA_Human1.16583535
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14707140
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.14218487
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.12774373
95POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12501368
96JUN_21703547_ChIP-Seq_K562_Human1.12082045
97BCAT_22108803_ChIP-Seq_LS180_Human1.11412622
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10389849
99TP53_22127205_ChIP-Seq_IMR90_Human1.09233141
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08822853
101AR_25329375_ChIP-Seq_VCAP_Human1.08326448
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07552281
103KDM2B_26808549_Chip-Seq_REH_Human1.07471416
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07317789
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06903266
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06692306
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06645896
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06645896
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.06441813
110* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06422269
111IGF1R_20145208_ChIP-Seq_DFB_Human1.06002231
112TCF4_23295773_ChIP-Seq_U87_Human1.05574430
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04963839
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04500305
115CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04464101
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04239517
117SALL1_21062744_ChIP-ChIP_HESCs_Human1.03986792
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01380000
119SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00896458
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00089359
121CBP_20019798_ChIP-Seq_JUKART_Human1.00089359
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99955266
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99845326
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99632297
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99550736
126RUNX2_22187159_ChIP-Seq_PCA_Human0.99470357
127PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.98836970
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98408716
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.97920512
130YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97859633
131TCF4_18268006_ChIP-ChIP_LS174T_Human0.97057460
132HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96204482
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.95200115
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95021080
135* AR_19668381_ChIP-Seq_PC3_Human0.94766598
136LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94284674
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93989984
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93809289
139ER_23166858_ChIP-Seq_MCF-7_Human0.92338610
140SA1_22415368_ChIP-Seq_MEFs_Mouse0.92272090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.38322248
2MP0005503_abnormal_tendon_morphology5.84116464
3MP0005275_abnormal_skin_tensile3.98819626
4MP0003279_aneurysm3.49650684
5MP0003950_abnormal_plasma_membrane3.06324810
6MP0009250_abnormal_appendicular_skeleto2.91243791
7MP0005257_abnormal_intraocular_pressure2.75561366
8MP0003385_abnormal_body_wall2.64575665
9MP0010030_abnormal_orbit_morphology2.60065068
10MP0003122_maternal_imprinting2.53567396
11MP0005508_abnormal_skeleton_morphology2.50077355
12MP0009384_cardiac_valve_regurgitation2.42177717
13MP0001958_emphysema2.20646592
14MP0000566_synostosis2.19512041
15MP0004134_abnormal_chest_morphology2.17380933
16MP0000049_abnormal_middle_ear2.05492894
17MP0005171_absent_coat_pigmentation2.01937865
18MP0003942_abnormal_urinary_system1.89446041
19MP0004272_abnormal_basement_membrane1.89328589
20MP0005623_abnormal_meninges_morphology1.87656997
21MP0002282_abnormal_trachea_morphology1.84648930
22MP0003705_abnormal_hypodermis_morpholog1.83636804
23MP0001299_abnormal_eye_distance/1.82613537
24MP0003941_abnormal_skin_development1.82595856
25MP0003755_abnormal_palate_morphology1.81976833
26MP0009053_abnormal_anal_canal1.81905578
27MP0000372_irregular_coat_pigmentation1.80543174
28MP0005408_hypopigmentation1.80466840
29MP0002249_abnormal_larynx_morphology1.79980820
30MP0002932_abnormal_joint_morphology1.67499992
31MP0000163_abnormal_cartilage_morphology1.66333626
32MP0002108_abnormal_muscle_morphology1.65104978
33MP0002938_white_spotting1.63750490
34MP0010386_abnormal_urinary_bladder1.61718020
35MP0002233_abnormal_nose_morphology1.57502002
36MP0000534_abnormal_ureter_morphology1.54671075
37MP0002115_abnormal_skeleton_extremities1.53065065
38MP0003937_abnormal_limbs/digits/tail_de1.52728569
39MP0000762_abnormal_tongue_morphology1.52018504
40MP0002116_abnormal_craniofacial_bone1.49760933
41MP0002295_abnormal_pulmonary_circulatio1.47835688
42MP0001542_abnormal_bone_strength1.47757862
43MP0006072_abnormal_retinal_apoptosis1.45665375
44MP0006054_spinal_hemorrhage1.45347610
45MP0000428_abnormal_craniofacial_morphol1.44768234
46MP0002109_abnormal_limb_morphology1.42529159
47MP0002896_abnormal_bone_mineralization1.42516150
48MP0001348_abnormal_lacrimal_gland1.41929428
49MP0002113_abnormal_skeleton_development1.41126590
50MP0003283_abnormal_digestive_organ1.37499962
51MP0003566_abnormal_cell_adhesion1.36459817
52MP0003935_abnormal_craniofacial_develop1.30834043
53MP0005390_skeleton_phenotype1.30293971
54MP0000432_abnormal_head_morphology1.26272612
55MP0003878_abnormal_ear_physiology1.26090610
56MP0005377_hearing/vestibular/ear_phenot1.26090610
57MP0002060_abnormal_skin_morphology1.22617427
58MP0003195_calcinosis1.18630771
59MP0003121_genomic_imprinting1.17097994
60MP0002933_joint_inflammation1.14308464
61MP0001346_abnormal_lacrimal_gland1.13920893
62MP0008004_abnormal_stomach_pH1.13660057
63MP0001270_distended_abdomen1.12289992
64MP0003091_abnormal_cell_migration1.11187931
65MP0002177_abnormal_outer_ear1.10742797
66MP0000767_abnormal_smooth_muscle1.05505102
67MP0004133_heterotaxia1.04974542
68MP0000733_abnormal_muscle_development1.04018959
69MP0003938_abnormal_ear_development1.03587353
70MP0003115_abnormal_respiratory_system1.01494226
71MP0004233_abnormal_muscle_weight1.00758611
72MP0000015_abnormal_ear_pigmentation0.99484334
73MP0002114_abnormal_axial_skeleton0.97403566
74MP0005367_renal/urinary_system_phenotyp0.96417143
75MP0000516_abnormal_urinary_system0.96417143
76MP0004858_abnormal_nervous_system0.96312749
77MP0002111_abnormal_tail_morphology0.94620461
78MP0005023_abnormal_wound_healing0.90350898
79MP0005248_abnormal_Harderian_gland0.89670173
80MP0003136_yellow_coat_color0.89144077
81MP0005253_abnormal_eye_physiology0.88846790
82MP0000678_abnormal_parathyroid_gland0.88056294
83MP0002168_other_aberrant_phenotype0.86948601
84MP0009780_abnormal_chondrocyte_physiolo0.86825525
85MP0002998_abnormal_bone_remodeling0.86528287
86MP0005595_abnormal_vascular_smooth0.84943784
87MP0000613_abnormal_salivary_gland0.83614938
88MP0000371_diluted_coat_color0.83033384
89MP0001293_anophthalmia0.82234237
90MP0005164_abnormal_response_to0.80603501
91MP0001243_abnormal_dermal_layer0.79297392
92MP0001177_atelectasis0.78768039
93MP0002139_abnormal_hepatobiliary_system0.78348576
94MP0003795_abnormal_bone_structure0.77141760
95MP0006292_abnormal_olfactory_placode0.76356426
96MP0002089_abnormal_postnatal_growth/wei0.76323366
97MP0000003_abnormal_adipose_tissue0.76315178
98MP0002254_reproductive_system_inflammat0.73670458
99MP0000462_abnormal_digestive_system0.73374788
100MP0008775_abnormal_heart_ventricle0.72986079
101MP0010368_abnormal_lymphatic_system0.72300564
102MP0000026_abnormal_inner_ear0.72188134
103MP0002128_abnormal_blood_circulation0.71756972
104MP0005165_increased_susceptibility_to0.71532980
105MP0005167_abnormal_blood-brain_barrier0.70476027
106MP0001340_abnormal_eyelid_morphology0.69673335
107MP0000569_abnormal_digit_pigmentation0.69457285
108MP0001879_abnormal_lymphatic_vessel0.68250726
109MP0002876_abnormal_thyroid_physiology0.68095089
110MP0002697_abnormal_eye_size0.67751286
111MP0005193_abnormal_anterior_eye0.67407725
112MP0000778_abnormal_nervous_system0.66616921
113MP0000681_abnormal_thyroid_gland0.66601566
114MP0002736_abnormal_nociception_after0.66059115
115MP0001614_abnormal_blood_vessel0.65930445
116MP0002102_abnormal_ear_morphology0.65472622
117MP0009697_abnormal_copulation0.65360036
118MP0000013_abnormal_adipose_tissue0.65329386
119MP0001175_abnormal_lung_morphology0.63837211
120MP0001286_abnormal_eye_development0.63782276
121MP0005197_abnormal_uvea_morphology0.63449750
122MP0002160_abnormal_reproductive_system0.63016186
123MP0001324_abnormal_eye_pigmentation0.62824979
124MP0000427_abnormal_hair_cycle0.61246617
125MP0002163_abnormal_gland_morphology0.60738599
126MP0005076_abnormal_cell_differentiation0.60116273
127MP0006276_abnormal_autonomic_nervous0.59681372
128MP0000749_muscle_degeneration0.59648469
129MP0000343_altered_response_to0.59363701
130MP0005395_other_phenotype0.58763072
131MP0000538_abnormal_urinary_bladder0.58431919
132MP0002877_abnormal_melanocyte_morpholog0.58092400
133MP0003646_muscle_fatigue0.58076385
134MP0010771_integument_phenotype0.54761838
135MP0005391_vision/eye_phenotype0.53726888
136MP0005551_abnormal_eye_electrophysiolog0.52465941

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.12387580
2Premature rupture of membranes (HP:0001788)6.85365436
3Absent frontal sinuses (HP:0002688)4.81288932
4Neonatal short-limb short stature (HP:0008921)4.59611312
5Shallow orbits (HP:0000586)4.23414474
6Aortic dissection (HP:0002647)4.22903550
7Abnormality of dentin (HP:0010299)4.20433190
8Soft skin (HP:0000977)3.88652867
9Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.69613240
10Follicular hyperkeratosis (HP:0007502)3.67221854
11Atrophic scars (HP:0001075)3.63585186
12Peritonitis (HP:0002586)3.57530160
13Biconcave vertebral bodies (HP:0004586)3.44886221
14Genu recurvatum (HP:0002816)3.43214455
15Morphological abnormality of the middle ear (HP:0008609)3.34845612
16Broad metatarsal (HP:0001783)3.34123434
17Keratoconus (HP:0000563)3.25704206
18Increased corneal curvature (HP:0100692)3.25704206
19Metaphyseal dysplasia (HP:0100255)3.25698274
20Bladder diverticulum (HP:0000015)3.21511825
21Mesomelia (HP:0003027)3.17924871
22Cervical subluxation (HP:0003308)3.16024432
23Vertebral compression fractures (HP:0002953)3.15540603
24Fragile skin (HP:0001030)3.06782513
25Aortic aneurysm (HP:0004942)3.04798341
26Abnormality of the frontal sinuses (HP:0002687)3.03427873
27Blue sclerae (HP:0000592)2.98548452
28Dilatation of the ascending aorta (HP:0005111)2.91588749
29Wormian bones (HP:0002645)2.88694236
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.87722913
31Osteolytic defects of the hand bones (HP:0009699)2.87722913
32Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.84318573
33Delayed closure of the anterior fontanelle (HP:0001476)2.83646835
34Ankle contracture (HP:0006466)2.81629298
35Mild short stature (HP:0003502)2.74980733
36Wide anterior fontanel (HP:0000260)2.72138566
37Bell-shaped thorax (HP:0001591)2.63997318
38Epiphyseal dysplasia (HP:0002656)2.62311833
39Microglossia (HP:0000171)2.60538532
40Vascular tortuosity (HP:0004948)2.57882281
41Persistence of primary teeth (HP:0006335)2.53271889
42Nonimmune hydrops fetalis (HP:0001790)2.43086359
43Mitral valve prolapse (HP:0001634)2.43038262
44Broad long bones (HP:0005622)2.42670008
45Coronal craniosynostosis (HP:0004440)2.42042489
46Ulnar bowing (HP:0003031)2.41872037
47Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.40593977
48Ectopia lentis (HP:0001083)2.39750773
49Breech presentation (HP:0001623)2.38450269
50Hypoplastic ischia (HP:0003175)2.37138935
51Spinal rigidity (HP:0003306)2.35360155
52Osteoarthritis (HP:0002758)2.33961697
53Radial bowing (HP:0002986)2.32899821
54Infantile muscular hypotonia (HP:0008947)2.31897540
55Fibular hypoplasia (HP:0003038)2.30202890
56Type II lissencephaly (HP:0007260)2.28458166
57Abnormal delivery (HP:0001787)2.26475973
58Vitreoretinal degeneration (HP:0000655)2.25950055
59Hyperextensible skin (HP:0000974)2.24946539
60Irregular vertebral endplates (HP:0003301)2.24852531
61Overgrowth (HP:0001548)2.22291190
62Wrist flexion contracture (HP:0001239)2.22028680
63Short 4th metacarpal (HP:0010044)2.21819179
64Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21819179
65Bowel diverticulosis (HP:0005222)2.19272055
66Type 1 muscle fiber predominance (HP:0003803)2.19073682
67Cerebral aneurysm (HP:0004944)2.18003830
68Decreased skull ossification (HP:0004331)2.17538551
69Abnormality of the acetabulum (HP:0003170)2.15739957
70Delayed cranial suture closure (HP:0000270)2.15549240
71Joint laxity (HP:0001388)2.13774594
72Arterial tortuosity (HP:0005116)2.12763070
73Limited hip movement (HP:0008800)2.10947032
74Narrow nasal bridge (HP:0000446)2.09640174
75Tibial bowing (HP:0002982)2.06677923
76Delayed gross motor development (HP:0002194)2.05171444
77Syringomyelia (HP:0003396)2.04755711
78Spinal cord lesions (HP:0100561)2.04755711
79Mitral stenosis (HP:0001718)2.03344001
80Abnormality of the ischium (HP:0003174)2.02432292
81Short middle phalanx of the 5th finger (HP:0004220)2.01493023
82Broad phalanx (HP:0006009)2.00202963
83Flat capital femoral epiphysis (HP:0003370)1.99985437
84Asymmetry of the thorax (HP:0001555)1.95412066
85Tracheomalacia (HP:0002779)1.93125778
86Disproportionate short-trunk short stature (HP:0003521)1.93048221
87Aplasia/Hypoplasia of the fibula (HP:0006492)1.92945548
88Broad ribs (HP:0000885)1.90878647
89Deviation of the hallux (HP:0010051)1.90687828
90Elbow flexion contracture (HP:0002987)1.90232325
91Abnormality of skull ossification (HP:0002703)1.89279808
92Spondylolisthesis (HP:0003302)1.88943542
93Tubular atrophy (HP:0000092)1.88607883
94Mitral regurgitation (HP:0001653)1.84197035
95Bowing of the arm (HP:0006488)1.82841850
96Bowed forearm bones (HP:0003956)1.82841850
97Choroideremia (HP:0001139)1.82533088
98Abnormality of incisor morphology (HP:0011063)1.81396646
99Cutaneous finger syndactyly (HP:0010554)1.80746553
100Platyspondyly (HP:0000926)1.80260840
101Hip contracture (HP:0003273)1.79632717
102Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.79541141
103Abnormality of femoral epiphyses (HP:0006499)1.79541141
104Small epiphyses (HP:0010585)1.78133711
105Slender build (HP:0001533)1.78089473
106Cupped ribs (HP:0000887)1.78074494
107Hallux valgus (HP:0001822)1.77683527
108Anterior segment dysgenesis (HP:0007700)1.76660344
109Arthropathy (HP:0003040)1.76071786
110Subacute progressive viral hepatitis (HP:0006572)1.75391914
111Coxa vara (HP:0002812)1.75359136
112Cardiovascular calcification (HP:0011915)1.75217906
113Redundant skin (HP:0001582)1.74384118
114Venous insufficiency (HP:0005293)1.74246048
115Camptodactyly of toe (HP:0001836)1.74080085
116Broad finger (HP:0001500)1.73900728
117Ovoid vertebral bodies (HP:0003300)1.73290887
118Abnormality of the vertebral endplates (HP:0005106)1.73192174
119Protruding ear (HP:0000411)1.72780629
120Retinal detachment (HP:0000541)1.71933156
121Limited elbow extension (HP:0001377)1.71446198
122Molar tooth sign on MRI (HP:0002419)1.70892043
123Abnormality of midbrain morphology (HP:0002418)1.70892043
124Abnormality of the parietal bone (HP:0002696)1.70147967
125Broad thumb (HP:0011304)1.69311210
126Spinal cord compression (HP:0002176)1.69001697
127Broad phalanges of the hand (HP:0009768)1.68935602
128Aortic regurgitation (HP:0001659)1.68930031
129Alopecia of scalp (HP:0002293)1.68490579
130Abnormality of proline metabolism (HP:0010907)1.68121156
131Hydroxyprolinuria (HP:0003080)1.68121156
132Midline defect of the nose (HP:0004122)1.67886413
133Dislocated radial head (HP:0003083)1.67657043
134Abnormality of the pubic bones (HP:0003172)1.67218834
135Femoral bowing (HP:0002980)1.67163210
136Tarsal synostosis (HP:0008368)1.66013809
137Increased number of teeth (HP:0011069)1.65642373
138Aortic valve stenosis (HP:0001650)1.65412794
139Irregular epiphyses (HP:0010582)1.65278648
140Synostosis of carpal bones (HP:0005048)1.64898739
141Inguinal hernia (HP:0000023)1.64689511
142Hepatoblastoma (HP:0002884)1.63796190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.44737121
2LATS13.96867916
3LATS23.87655005
4TIE13.59096132
5EPHB23.41001775
6CASK3.38422823
7SIK33.37041539
8STK38L3.31612186
9SIK13.25461367
10INSRR3.17009401
11EPHA32.67698624
12ADRBK22.53473246
13PDGFRA2.13031505
14ERBB32.11569214
15MAP3K122.11133452
16CDK82.08328727
17STK31.99264053
18ACVR1B1.96716667
19WNK41.92548374
20PLK21.85160784
21MET1.78358609
22PAK31.73309954
23FER1.62556058
24ZAK1.53582914
25PAK21.52284684
26GRK11.48101219
27TRPM71.45373125
28MAP4K21.44413945
29STK241.41466476
30NEK91.38986743
31MAPK131.37381843
32PNCK1.36978412
33TGFBR11.35508687
34NTRK31.35391135
35BMPR1B1.34694054
36MAPKAPK31.33606623
37PIK3CA1.30975489
38PRPF4B1.20974675
39FLT31.19772716
40ROCK11.19021234
41NUAK11.18669552
42EIF2AK21.17898417
43PTK2B1.16545415
44TTN1.16310846
45PIM21.15392094
46MST1R1.12500825
47MAPKAPK51.11130207
48GSK3A1.08947609
49MUSK1.08851692
50FGFR11.07325015
51ABL21.05945940
52PINK11.05941462
53LIMK11.04431873
54DMPK1.04206011
55WNK11.03637709
56PDK21.03420932
57PRKD21.01469607
58TRIB30.98291107
59CDC42BPA0.97713256
60PRKCE0.95704536
61RPS6KA40.95314977
62PTK20.91789755
63KSR10.88230950
64MYLK0.86081559
65SIK20.85511053
66MARK30.81685836
67IRAK30.78889630
68NLK0.78426034
69ROCK20.77593802
70ADRBK10.76145165
71BMX0.73325788
72NTRK10.73185584
73ERN10.72926115
74TAOK20.71482588
75MELK0.70585579
76FRK0.69191025
77NTRK20.68694590
78PAK60.66015600
79PLK30.65471397
80SGK20.64278976
81WEE10.63739147
82CAMKK20.63459599
83PRKD30.62066973
84DAPK20.61065827
85BCR0.61061471
86STK390.60876303
87ERBB20.60609612
88CSNK1G20.58014123
89AKT30.56840475
90INSR0.55864540
91EPHB10.54654813
92BRSK20.54632050
93DYRK20.52848371
94MINK10.52079631
95CSNK1A1L0.51164430
96MKNK20.50664438
97CDK30.50171156
98GRK50.49208172
99PIK3CG0.48753458
100FGFR20.47627071
101MAP2K70.47412703
102CAMK2D0.46941946
103CLK10.46639352
104TNIK0.46592257
105MOS0.46372415
106PAK40.46181067
107MKNK10.45507367
108MST40.45503186
109PRKCH0.45373329
110PRKG20.45110732
111WNK30.44190953
112NEK60.43853536
113TRIM280.43700113
114SRC0.43549660
115LMTK20.43512478
116DAPK30.43250071
117PRKCG0.43240845
118TESK10.43055476
119EPHA40.41224656
120CSNK1G30.41000485
121PBK0.40525077
122PDGFRB0.39755609
123CAMK2G0.39461117
124MARK10.38916765
125ERBB40.38635326
126CHUK0.38195643
127CAMK10.37436268
128ABL10.36660109
129PRKAA20.36417288
130MAP3K20.36160079
131MTOR0.35478455
132CAMK2A0.34738608
133CAMK1D0.34264520
134STK380.34209992
135CAMK1G0.34147480
136TGFBR20.33514124
137PRKG10.33335114
138CAMK40.32750773
139MAP2K10.32236883
140CDK70.31545527
141IGF1R0.30893896
142CSNK1A10.27020458
143BMPR20.26554573
144MAPK10.24312404
145CSNK1G10.24002618
146ILK0.23764457
147SGK30.23637965
148CHEK20.22930278
149AKT10.21798486

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.64009605
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.03669793
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.65538826
4Focal adhesion_Homo sapiens_hsa045102.32047372
5Protein digestion and absorption_Homo sapiens_hsa049742.31719835
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.31601111
7Basal cell carcinoma_Homo sapiens_hsa052172.27869616
8TGF-beta signaling pathway_Homo sapiens_hsa043502.21569122
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.12734372
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07775464
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.05272790
12Hippo signaling pathway_Homo sapiens_hsa043902.04332924
13Hedgehog signaling pathway_Homo sapiens_hsa043401.98269742
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.96682475
15Axon guidance_Homo sapiens_hsa043601.87475570
16Dilated cardiomyopathy_Homo sapiens_hsa054141.87428852
17Melanoma_Homo sapiens_hsa052181.75898984
18Wnt signaling pathway_Homo sapiens_hsa043101.72147944
19Malaria_Homo sapiens_hsa051441.71074768
20Adherens junction_Homo sapiens_hsa045201.69573546
21Proteoglycans in cancer_Homo sapiens_hsa052051.63274673
22Protein export_Homo sapiens_hsa030601.61221444
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.59866553
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.59822194
25PI3K-Akt signaling pathway_Homo sapiens_hsa041511.59041480
26Selenocompound metabolism_Homo sapiens_hsa004501.54685045
27Phototransduction_Homo sapiens_hsa047441.52607346
28MicroRNAs in cancer_Homo sapiens_hsa052061.50185376
29Lysosome_Homo sapiens_hsa041421.42270491
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42252316
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36047096
32Amoebiasis_Homo sapiens_hsa051461.33872951
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31507518
34Nicotine addiction_Homo sapiens_hsa050331.28173421
35Prostate cancer_Homo sapiens_hsa052151.25817887
36Melanogenesis_Homo sapiens_hsa049161.25700084
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.25589391
38Nitrogen metabolism_Homo sapiens_hsa009101.24697590
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20684513
40Bladder cancer_Homo sapiens_hsa052191.20609877
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20330108
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17318507
43p53 signaling pathway_Homo sapiens_hsa041151.13897057
44Rap1 signaling pathway_Homo sapiens_hsa040151.11240858
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09658531
46Regulation of autophagy_Homo sapiens_hsa041401.09528444
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07744772
48Basal transcription factors_Homo sapiens_hsa030221.03029801
49ABC transporters_Homo sapiens_hsa020101.02576820
50Pathways in cancer_Homo sapiens_hsa052001.02558882
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01542020
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99462606
53Glioma_Homo sapiens_hsa052140.99173804
54Ovarian steroidogenesis_Homo sapiens_hsa049130.98704269
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98427585
56Dorso-ventral axis formation_Homo sapiens_hsa043200.94705320
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91433524
58N-Glycan biosynthesis_Homo sapiens_hsa005100.90482283
59Cocaine addiction_Homo sapiens_hsa050300.90182854
60Sulfur metabolism_Homo sapiens_hsa009200.89839675
61Gap junction_Homo sapiens_hsa045400.89515664
62Small cell lung cancer_Homo sapiens_hsa052220.88617555
63Chronic myeloid leukemia_Homo sapiens_hsa052200.88247665
64Ras signaling pathway_Homo sapiens_hsa040140.87075235
65Ether lipid metabolism_Homo sapiens_hsa005650.85678812
66Folate biosynthesis_Homo sapiens_hsa007900.85498923
67Circadian entrainment_Homo sapiens_hsa047130.85317046
68Phagosome_Homo sapiens_hsa041450.83759306
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83119219
70HTLV-I infection_Homo sapiens_hsa051660.82701650
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79638757
72TNF signaling pathway_Homo sapiens_hsa046680.78000144
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.77858717
74Pancreatic cancer_Homo sapiens_hsa052120.76878417
75Complement and coagulation cascades_Homo sapiens_hsa046100.76331146
76Serotonergic synapse_Homo sapiens_hsa047260.76092466
77Colorectal cancer_Homo sapiens_hsa052100.75357639
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75252007
79Linoleic acid metabolism_Homo sapiens_hsa005910.73940871
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72659794
81ErbB signaling pathway_Homo sapiens_hsa040120.71887729
82Long-term depression_Homo sapiens_hsa047300.71833830
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71455300
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70938277
85Calcium signaling pathway_Homo sapiens_hsa040200.70802881
86Endometrial cancer_Homo sapiens_hsa052130.70203882
87Morphine addiction_Homo sapiens_hsa050320.69037001
88Insulin secretion_Homo sapiens_hsa049110.67767787
89Tight junction_Homo sapiens_hsa045300.67619808
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.67388997
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.66286219
92cAMP signaling pathway_Homo sapiens_hsa040240.66188613
93Amphetamine addiction_Homo sapiens_hsa050310.64963526
94Rheumatoid arthritis_Homo sapiens_hsa053230.64862121
95Taste transduction_Homo sapiens_hsa047420.64510187
96Estrogen signaling pathway_Homo sapiens_hsa049150.64461413
97GnRH signaling pathway_Homo sapiens_hsa049120.64005616
98Thyroid hormone synthesis_Homo sapiens_hsa049180.63236537
99Glutamatergic synapse_Homo sapiens_hsa047240.63165209
100Cell cycle_Homo sapiens_hsa041100.62967923
101Glutathione metabolism_Homo sapiens_hsa004800.62375859
102Olfactory transduction_Homo sapiens_hsa047400.62156232
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61440448
104Notch signaling pathway_Homo sapiens_hsa043300.60985853
105Hepatitis B_Homo sapiens_hsa051610.60153049
106MAPK signaling pathway_Homo sapiens_hsa040100.59502826
107Mineral absorption_Homo sapiens_hsa049780.59073700
108Cholinergic synapse_Homo sapiens_hsa047250.58750760
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.57429630
110Oxytocin signaling pathway_Homo sapiens_hsa049210.57269328
111Renin-angiotensin system_Homo sapiens_hsa046140.56490525
112Arachidonic acid metabolism_Homo sapiens_hsa005900.56375085
113Tryptophan metabolism_Homo sapiens_hsa003800.56069569
114Viral myocarditis_Homo sapiens_hsa054160.55826790
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54181353
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54107010
117Homologous recombination_Homo sapiens_hsa034400.52754462
118Renal cell carcinoma_Homo sapiens_hsa052110.52665872
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51575775
120FoxO signaling pathway_Homo sapiens_hsa040680.51534729
121Circadian rhythm_Homo sapiens_hsa047100.50356566
122Retinol metabolism_Homo sapiens_hsa008300.50131168
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50112390
124Pertussis_Homo sapiens_hsa051330.49485870
125Sphingolipid metabolism_Homo sapiens_hsa006000.49074895
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48805912
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48143773
128GABAergic synapse_Homo sapiens_hsa047270.47834094
129Platelet activation_Homo sapiens_hsa046110.47575509
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.46468774
131Dopaminergic synapse_Homo sapiens_hsa047280.46126863
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45938466
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.45593652
134Choline metabolism in cancer_Homo sapiens_hsa052310.44048499
135Fanconi anemia pathway_Homo sapiens_hsa034600.35784702
136Butanoate metabolism_Homo sapiens_hsa006500.33990773
137Sulfur relay system_Homo sapiens_hsa041220.32438357
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.28913357
139Vibrio cholerae infection_Homo sapiens_hsa051100.27321899
140Galactose metabolism_Homo sapiens_hsa000520.25616569
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25310865
142Insulin resistance_Homo sapiens_hsa049310.22220891
143Chemical carcinogenesis_Homo sapiens_hsa052040.21481796
144Collecting duct acid secretion_Homo sapiens_hsa049660.20586414
145African trypanosomiasis_Homo sapiens_hsa051430.19051564

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