P4HTM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.37159037
2cilium or flagellum-dependent cell motility (GO:0001539)5.76401283
3cilium movement (GO:0003341)5.37249313
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.22660407
5motile cilium assembly (GO:0044458)5.12536103
6synaptic vesicle maturation (GO:0016188)4.94976616
7synaptic vesicle exocytosis (GO:0016079)4.92699742
8neuronal action potential propagation (GO:0019227)4.79658725
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78113252
10neuron cell-cell adhesion (GO:0007158)4.64130312
11glutamate secretion (GO:0014047)4.61461621
12regulation of synaptic vesicle exocytosis (GO:2000300)4.59533374
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.58175130
14vocalization behavior (GO:0071625)4.56925235
15epithelial cilium movement (GO:0003351)4.56313205
16locomotory exploration behavior (GO:0035641)4.56305347
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.49085480
18protein localization to synapse (GO:0035418)4.38928278
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.38527700
20regulation of glutamate receptor signaling pathway (GO:1900449)4.10214115
21regulation of synaptic vesicle transport (GO:1902803)4.08284417
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.92254507
23axoneme assembly (GO:0035082)3.89409169
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.85773691
25left/right pattern formation (GO:0060972)3.85322430
26regulation of neuronal synaptic plasticity (GO:0048168)3.83842658
27exploration behavior (GO:0035640)3.81419379
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80552311
29neurotransmitter secretion (GO:0007269)3.78034939
30synaptic transmission, glutamatergic (GO:0035249)3.72925153
31glutamate receptor signaling pathway (GO:0007215)3.71476131
32neuron-neuron synaptic transmission (GO:0007270)3.69555005
33neuromuscular process controlling posture (GO:0050884)3.69389236
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59364422
35regulation of ARF protein signal transduction (GO:0032012)3.57562595
36cerebellar granule cell differentiation (GO:0021707)3.57180449
37presynaptic membrane assembly (GO:0097105)3.52299132
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51101063
39long-term memory (GO:0007616)3.49140640
40detection of calcium ion (GO:0005513)3.49123722
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.47325554
42transmission of nerve impulse (GO:0019226)3.44760527
43positive regulation of membrane potential (GO:0045838)3.44665750
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42785159
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.38358014
46presynaptic membrane organization (GO:0097090)3.37697338
47neuron recognition (GO:0008038)3.34270209
48long-term synaptic potentiation (GO:0060291)3.34265950
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.33855826
50cellular potassium ion homeostasis (GO:0030007)3.32451219
51neurotransmitter transport (GO:0006836)3.31066676
52regulation of synapse structural plasticity (GO:0051823)3.29428340
53gamma-aminobutyric acid transport (GO:0015812)3.28923249
54neurotransmitter-gated ion channel clustering (GO:0072578)3.25172721
55regulation of neurotransmitter secretion (GO:0046928)3.24988349
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24666509
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24316862
58regulation of postsynaptic membrane potential (GO:0060078)3.20369302
59sodium ion export (GO:0071436)3.18902308
60regulation of synaptic plasticity (GO:0048167)3.17968279
61dendritic spine morphogenesis (GO:0060997)3.15747103
62synaptic vesicle endocytosis (GO:0048488)3.13652274
63layer formation in cerebral cortex (GO:0021819)3.12525359
64postsynaptic membrane organization (GO:0001941)3.11494906
65cerebellar Purkinje cell differentiation (GO:0021702)3.11160864
66regulation of vesicle fusion (GO:0031338)3.10584528
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09753821
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.06668379
69neuronal ion channel clustering (GO:0045161)3.05392624
70negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05363049
71positive regulation of synapse maturation (GO:0090129)3.02764161
72regulation of voltage-gated calcium channel activity (GO:1901385)3.02609719
73regulation of neurotransmitter transport (GO:0051588)3.01788579
74membrane depolarization during action potential (GO:0086010)3.00826633
75response to auditory stimulus (GO:0010996)3.00825790
76adult walking behavior (GO:0007628)2.99576731
77regulation of neurotransmitter levels (GO:0001505)2.97749691
78axon ensheathment in central nervous system (GO:0032291)2.97620798
79central nervous system myelination (GO:0022010)2.97620798
80membrane hyperpolarization (GO:0060081)2.97503103
81axonal fasciculation (GO:0007413)2.96306242
82mating behavior (GO:0007617)2.93147839
83membrane depolarization (GO:0051899)2.92587224
84synaptic transmission (GO:0007268)2.89231311
85dendritic spine organization (GO:0097061)2.88279799
86positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86953740
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84707682
88activation of protein kinase A activity (GO:0034199)2.84371073
89regulation of cilium movement (GO:0003352)2.84341611
90regulation of glutamate secretion (GO:0014048)2.84195835
91microtubule bundle formation (GO:0001578)2.83744503
92positive regulation of neurotransmitter transport (GO:0051590)2.82321683
93behavioral response to cocaine (GO:0048148)2.82189198
94L-amino acid import (GO:0043092)2.81395144
95synapse assembly (GO:0007416)2.79354658
96learning (GO:0007612)2.79275590
97neuronal action potential (GO:0019228)2.79233090
98negative regulation of neurotransmitter transport (GO:0051589)2.78933983
99protein localization to cilium (GO:0061512)2.78690166
100positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.78078239
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77883751
102regulation of synaptic transmission (GO:0050804)2.77879978
103cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77622173
104positive regulation of synaptic transmission (GO:0050806)2.77619355
105neuromuscular process controlling balance (GO:0050885)2.76899715
106peptidyl-tyrosine autophosphorylation (GO:0038083)2.75583063
107proline transport (GO:0015824)2.75269050
108glycine transport (GO:0015816)2.74713188
109auditory behavior (GO:0031223)2.71923318
110regulation of dendritic spine morphogenesis (GO:0061001)2.71839790
111long-chain fatty acid biosynthetic process (GO:0042759)2.71817013
112regulation of synaptic transmission, GABAergic (GO:0032228)2.71770212
113striatum development (GO:0021756)2.70906890
114response to histamine (GO:0034776)2.70259298
115behavioral defense response (GO:0002209)2.69222039
116behavioral fear response (GO:0001662)2.69222039
117potassium ion homeostasis (GO:0055075)2.66312859
118regulation of microtubule-based movement (GO:0060632)2.66218071
119positive regulation of neurotransmitter secretion (GO:0001956)2.61310070
120establishment of mitochondrion localization (GO:0051654)2.58037072
121long term synaptic depression (GO:0060292)2.57656315
122dopamine receptor signaling pathway (GO:0007212)2.56953409
123chemosensory behavior (GO:0007635)2.53449614
124regulation of autophagic vacuole assembly (GO:2000785)2.53161759
125ventricular system development (GO:0021591)2.51532127
126neurotransmitter catabolic process (GO:0042135)2.51453379
127regulation of synapse maturation (GO:0090128)2.51094151
128negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48677032
129regulation of female receptivity (GO:0045924)2.44719759
130adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.42162806
131macroautophagy (GO:0016236)2.36196132
132cell migration in hindbrain (GO:0021535)2.35491107
133signal release (GO:0023061)2.34280060
134lung epithelium development (GO:0060428)2.32308424
135potassium ion import (GO:0010107)2.31997006
136cellular sodium ion homeostasis (GO:0006883)2.26505916
137mitochondrion transport along microtubule (GO:0047497)2.26166399
138establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.26166399
139cell differentiation in hindbrain (GO:0021533)2.24606847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.85297193
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.03778927
3GBX2_23144817_ChIP-Seq_PC3_Human3.73706519
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18921087
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05159678
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97310310
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.71710385
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62854634
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61471614
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61471614
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58062968
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56077735
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53544408
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51230531
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50312365
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.49742466
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.42974261
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36569131
19DROSHA_22980978_ChIP-Seq_HELA_Human2.36429252
20LXR_22292898_ChIP-Seq_THP-1_Human2.34446048
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.34090162
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.31054188
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.27062555
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26433238
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.12062226
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10062147
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01181190
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92882100
29TAF15_26573619_Chip-Seq_HEK293_Human1.90512874
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80764780
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79993337
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.78661272
33* P68_20966046_ChIP-Seq_HELA_Human1.78564145
34* SMC4_20622854_ChIP-Seq_HELA_Human1.77479521
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76632959
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74498407
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74414925
38KDM2B_26808549_Chip-Seq_K562_Human1.74171514
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72402553
40AR_21572438_ChIP-Seq_LNCaP_Human1.69367356
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65745227
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.65283245
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64045319
44SMAD4_21799915_ChIP-Seq_A2780_Human1.60858945
45CREB1_26743006_Chip-Seq_LNCaP_Human1.54103504
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48344913
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47784121
48SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44632363
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44536851
50RACK7_27058665_Chip-Seq_MCF-7_Human1.43909715
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43346341
52VDR_22108803_ChIP-Seq_LS180_Human1.42615132
53P300_19829295_ChIP-Seq_ESCs_Human1.42083710
54* ELF1_20517297_ChIP-Seq_JURKAT_Human1.41106904
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38911631
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37624178
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36406731
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36252516
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35021390
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34773829
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34014776
62ZNF274_21170338_ChIP-Seq_K562_Hela1.32598760
63PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32336720
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.32288318
65* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30985848
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30844043
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.30479084
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29613762
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.29090355
70* BCL6_27268052_Chip-Seq_Bcells_Human1.28547699
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.28027286
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26967320
73KDM2B_26808549_Chip-Seq_DND41_Human1.25698156
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24884014
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.23460701
76* BCOR_27268052_Chip-Seq_Bcells_Human1.23164696
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22578513
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22468380
79TP63_22573176_ChIP-Seq_HFKS_Human1.22043278
80STAT3_23295773_ChIP-Seq_U87_Human1.20369324
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19436070
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.18669470
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.18626967
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18145832
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17737510
86AR_25329375_ChIP-Seq_VCAP_Human1.16665332
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15471912
88* PHF8_20622854_ChIP-Seq_HELA_Human1.14688229
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13156716
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.12941363
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12690636
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12457600
93* OCT4_19829295_ChIP-Seq_ESCs_Human1.10813972
94* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10742147
95* CTCF_20526341_ChIP-Seq_ESCs_Human1.09319159
96TCF4_23295773_ChIP-Seq_U87_Human1.08257550
97RNF2_27304074_Chip-Seq_NSC_Mouse1.08184932
98AR_19668381_ChIP-Seq_PC3_Human1.06139970
99* E2F1_20622854_ChIP-Seq_HELA_Human1.05555247
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04531435
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03921590
102RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03648113
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.02781858
104SA1_27219007_Chip-Seq_Bcells_Human1.02156761
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02143443
106VDR_21846776_ChIP-Seq_THP-1_Human1.02033118
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01728821
108ESR1_21235772_ChIP-Seq_MCF-7_Human1.01168740
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00752762
110RUNX2_22187159_ChIP-Seq_PCA_Human1.00677544
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00516380
112IGF1R_20145208_ChIP-Seq_DFB_Human1.00397762
113* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00295770
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99751830
115ER_23166858_ChIP-Seq_MCF-7_Human0.99562528
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99492644
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98965193
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98869874
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.97434865
120MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97299190
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97258589
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96558575
123AHR_22903824_ChIP-Seq_MCF-7_Human0.95806381
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.95530016
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94734663
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94682981
127RING1B_27294783_Chip-Seq_NPCs_Mouse0.94173781
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.93821268
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93809089
130FUS_26573619_Chip-Seq_HEK293_Human0.93570865
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93547321
132SMAD_19615063_ChIP-ChIP_OVARY_Human0.93414498
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91843867
134TP53_23651856_ChIP-Seq_MEFs_Mouse0.91584182
135KLF4_19829295_ChIP-Seq_ESCs_Human0.89727320
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89246097
137JUN_21703547_ChIP-Seq_K562_Human0.89192510
138FLI1_21867929_ChIP-Seq_CD8_Mouse0.89024453
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.88822593
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88596746
141TRIM28_21343339_ChIP-Seq_HEK293_Human0.88002671
142TP53_20018659_ChIP-ChIP_R1E_Mouse0.87957644
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.87677107
144YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86680436
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86108638
146RARB_24833708_ChIP-Seq_LIVER_Mouse0.86011153
147TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85589953
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84758137
149TET1_21490601_ChIP-Seq_MESCs_Mouse0.83708337
150TCF7_22412390_ChIP-Seq_EML_Mouse0.83670648
151CTCF_27219007_Chip-Seq_Bcells_Human0.83625636
152TP53_22127205_ChIP-Seq_IMR90_Human0.82939795
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82312789
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.82220403
155JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.82165424
156ELK3_25401928_ChIP-Seq_HUVEC_Human0.82057959
157ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81471027
158FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81202714
159KDM2B_26808549_Chip-Seq_REH_Human0.79772202
160OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79613506
161* SMAD4_21741376_ChIP-Seq_HESCs_Human0.79500429
162* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.78911761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.32528742
2MP0003880_abnormal_central_pattern4.81800980
3MP0003635_abnormal_synaptic_transmissio3.74437665
4MP0004270_analgesia3.72066300
5MP0009745_abnormal_behavioral_response3.21777220
6MP0002064_seizures3.10816130
7MP0001968_abnormal_touch/_nociception3.02659728
8MP0002653_abnormal_ependyma_morphology3.01980798
9MP0002063_abnormal_learning/memory/cond2.95553799
10MP0009046_muscle_twitch2.93388223
11MP0002272_abnormal_nervous_system2.88463121
12MP0005423_abnormal_somatic_nervous2.80969423
13MP0002572_abnormal_emotion/affect_behav2.68367689
14MP0002734_abnormal_mechanical_nocicepti2.67284082
15MP0002822_catalepsy2.50360261
16MP0001486_abnormal_startle_reflex2.50118642
17MP0002736_abnormal_nociception_after2.46164818
18MP0002735_abnormal_chemical_nociception2.39529302
19MP0001501_abnormal_sleep_pattern2.11704764
20MP0001440_abnormal_grooming_behavior2.11493891
21MP0002733_abnormal_thermal_nociception2.07657812
22MP0006276_abnormal_autonomic_nervous2.06510812
23MP0001970_abnormal_pain_threshold2.05518935
24MP0001529_abnormal_vocalization2.03407689
25MP0002067_abnormal_sensory_capabilities2.01758698
26MP0005646_abnormal_pituitary_gland1.99116401
27MP0001905_abnormal_dopamine_level1.86331467
28MP0003329_amyloid_beta_deposits1.85643144
29MP0001984_abnormal_olfaction1.81994874
30MP0004858_abnormal_nervous_system1.81905124
31MP0008875_abnormal_xenobiotic_pharmacok1.80318644
32MP0003172_abnormal_lysosome_physiology1.79159967
33MP0002184_abnormal_innervation1.74214552
34MP0008569_lethality_at_weaning1.72366480
35MP0004142_abnormal_muscle_tone1.66357222
36MP0002557_abnormal_social/conspecific_i1.64759832
37MP0005551_abnormal_eye_electrophysiolog1.60727754
38MP0000778_abnormal_nervous_system1.60130912
39MP0004924_abnormal_behavior1.59286781
40MP0005386_behavior/neurological_phenoty1.59286781
41MP0009780_abnormal_chondrocyte_physiolo1.58111198
42MP0000955_abnormal_spinal_cord1.49745327
43MP0005645_abnormal_hypothalamus_physiol1.49171821
44MP0002882_abnormal_neuron_morphology1.48711793
45MP0004811_abnormal_neuron_physiology1.47201097
46MP0000920_abnormal_myelination1.46861916
47MP0003122_maternal_imprinting1.45322919
48MP0002909_abnormal_adrenal_gland1.45079679
49MP0002066_abnormal_motor_capabilities/c1.41624062
50MP0001502_abnormal_circadian_rhythm1.41502490
51MP0004133_heterotaxia1.39937382
52MP0010386_abnormal_urinary_bladder1.38583437
53MP0002229_neurodegeneration1.32108772
54MP0003879_abnormal_hair_cell1.31609423
55MP0000751_myopathy1.31379803
56MP0004885_abnormal_endolymph1.30763010
57MP0005058_abnormal_lysosome_morphology1.24318905
58MP0003633_abnormal_nervous_system1.21982901
59MP0001986_abnormal_taste_sensitivity1.19573548
60MP0000013_abnormal_adipose_tissue1.18975400
61MP0002837_dystrophic_cardiac_calcinosis1.18860221
62MP0004145_abnormal_muscle_electrophysio1.18608007
63MP0004742_abnormal_vestibular_system1.18599428
64MP0001188_hyperpigmentation1.17607412
65MP0001765_abnormal_ion_homeostasis1.13578707
66MP0003634_abnormal_glial_cell1.12414798
67MP0003631_nervous_system_phenotype1.12202711
68MP0005377_hearing/vestibular/ear_phenot1.10894537
69MP0003878_abnormal_ear_physiology1.10894537
70MP0006072_abnormal_retinal_apoptosis1.07932360
71MP0003787_abnormal_imprinting1.03401047
72MP0002638_abnormal_pupillary_reflex1.02138845
73MP0002152_abnormal_brain_morphology1.00863906
74MP0004043_abnormal_pH_regulation1.00700703
75MP0002752_abnormal_somatic_nervous0.99851474
76MP0001963_abnormal_hearing_physiology0.98561009
77MP0000681_abnormal_thyroid_gland0.97760009
78MP0003283_abnormal_digestive_organ0.97153432
79MP0001485_abnormal_pinna_reflex0.94606699
80MP0003690_abnormal_glial_cell0.93213439
81MP0005253_abnormal_eye_physiology0.92130614
82MP0004085_abnormal_heartbeat0.90440025
83MP0003123_paternal_imprinting0.88577969
84MP0000566_synostosis0.88544547
85MP0002069_abnormal_eating/drinking_beha0.88504044
86MP0003632_abnormal_nervous_system0.87960253
87MP0001944_abnormal_pancreas_morphology0.87160925
88MP0000631_abnormal_neuroendocrine_gland0.83700619
89MP0005535_abnormal_body_temperature0.82178593
90MP0005171_absent_coat_pigmentation0.81344385
91MP0004215_abnormal_myocardial_fiber0.80316633
92MP0002090_abnormal_vision0.77688407
93MP0008872_abnormal_physiological_respon0.77317787
94MP0003075_altered_response_to0.76750208
95MP0002693_abnormal_pancreas_physiology0.73888690
96MP0003137_abnormal_impulse_conducting0.72924110
97MP0008874_decreased_physiological_sensi0.72448126
98MP0002249_abnormal_larynx_morphology0.71577882
99MP0005409_darkened_coat_color0.71558550
100MP0002876_abnormal_thyroid_physiology0.70500452
101MP0005394_taste/olfaction_phenotype0.70204435
102MP0005499_abnormal_olfactory_system0.70204435
103MP0000604_amyloidosis0.69146571
104MP0005410_abnormal_fertilization0.68115542
105MP0004019_abnormal_vitamin_homeostasis0.67614087
106MP0001664_abnormal_digestion0.66915142
107MP0001177_atelectasis0.66622817
108MP0009278_abnormal_bone_marrow0.66594218
109MP0008789_abnormal_olfactory_epithelium0.66513974
110MP0001756_abnormal_urination0.66224992
111MP0000639_abnormal_adrenal_gland0.63709461
112MP0002928_abnormal_bile_duct0.63299836
113MP0000026_abnormal_inner_ear0.61572935
114MP0004036_abnormal_muscle_relaxation0.60846170
115MP0000747_muscle_weakness0.58072435
116MP0003183_abnormal_peptide_metabolism0.57491672
117MP0005379_endocrine/exocrine_gland_phen0.57386819
118MP0005195_abnormal_posterior_eye0.57245096
119MP0004233_abnormal_muscle_weight0.54981354
120MP0005623_abnormal_meninges_morphology0.53240371
121MP0004484_altered_response_of0.52817004

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.12902289
2Abnormal respiratory epithelium morphology (HP:0012253)6.77591332
3Abnormal respiratory motile cilium morphology (HP:0005938)6.77591332
4Abnormal respiratory motile cilium physiology (HP:0012261)6.71994258
5Focal motor seizures (HP:0011153)6.66167706
6Abnormal ciliary motility (HP:0012262)6.36536493
7Dynein arm defect of respiratory motile cilia (HP:0012255)6.30539076
8Absent/shortened dynein arms (HP:0200106)6.30539076
9Rhinitis (HP:0012384)6.19402164
10Myokymia (HP:0002411)6.07053244
11Focal seizures (HP:0007359)5.04352995
12Atonic seizures (HP:0010819)4.84629521
13Chronic bronchitis (HP:0004469)4.82384529
14Nasal polyposis (HP:0100582)4.74319186
15Epileptic encephalopathy (HP:0200134)4.56470059
16Visual hallucinations (HP:0002367)4.52407180
17Bronchiectasis (HP:0002110)4.39129566
18Febrile seizures (HP:0002373)4.17780713
19Abnormality of the nasal mucosa (HP:0000433)3.97305793
20Progressive cerebellar ataxia (HP:0002073)3.89583784
21Absence seizures (HP:0002121)3.88047815
22Dialeptic seizures (HP:0011146)3.67613687
23Ankle clonus (HP:0011448)3.58029624
24Supranuclear gaze palsy (HP:0000605)3.55646564
25Generalized tonic-clonic seizures (HP:0002069)3.54807621
26Action tremor (HP:0002345)3.53444389
27Dysmetria (HP:0001310)3.12317645
28Neurofibrillary tangles (HP:0002185)3.11585975
29Atelectasis (HP:0100750)3.05319216
30Infertility (HP:0000789)3.02860807
31Truncal ataxia (HP:0002078)3.01916945
32Retinal dysplasia (HP:0007973)3.01195372
33Obstructive sleep apnea (HP:0002870)2.99884352
34Dysdiadochokinesis (HP:0002075)2.98620138
35Scanning speech (HP:0002168)2.97845621
36Abnormality of the corticospinal tract (HP:0002492)2.95453660
37Broad-based gait (HP:0002136)2.94030258
38Gaze-evoked nystagmus (HP:0000640)2.93992267
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.90981154
40Degeneration of the lateral corticospinal tracts (HP:0002314)2.90981154
41Anxiety (HP:0000739)2.90862750
42Pheochromocytoma (HP:0002666)2.89827275
43Impaired vibration sensation in the lower limbs (HP:0002166)2.89655146
44Recurrent sinusitis (HP:0011108)2.89049647
45Spastic gait (HP:0002064)2.88107327
46Insidious onset (HP:0003587)2.79366449
47Termporal pattern (HP:0011008)2.79366449
48Depression (HP:0000716)2.77702815
49Hand muscle atrophy (HP:0009130)2.70638733
50Cerebral inclusion bodies (HP:0100314)2.70344315
51Occipital encephalocele (HP:0002085)2.68483354
52Urinary bladder sphincter dysfunction (HP:0002839)2.68166680
53Hyperventilation (HP:0002883)2.64267810
54Postural instability (HP:0002172)2.63398936
55Bronchitis (HP:0012387)2.60632808
56Limb dystonia (HP:0002451)2.59368541
57Papilledema (HP:0001085)2.58364827
58Neuroendocrine neoplasm (HP:0100634)2.57863249
59Abnormal eating behavior (HP:0100738)2.55243868
60Poor eye contact (HP:0000817)2.52332055
61Epileptiform EEG discharges (HP:0011182)2.51844466
62Recurrent otitis media (HP:0000403)2.48772500
63Chronic sinusitis (HP:0011109)2.47161918
64Gait imbalance (HP:0002141)2.46789686
65Amblyopia (HP:0000646)2.45041777
66Hemiparesis (HP:0001269)2.43820225
67EEG with generalized epileptiform discharges (HP:0011198)2.42934833
68Urinary urgency (HP:0000012)2.36653580
69Male infertility (HP:0003251)2.34165009
70Upper limb amyotrophy (HP:0009129)2.30807170
71Distal upper limb amyotrophy (HP:0007149)2.30807170
72Lower limb muscle weakness (HP:0007340)2.28316686
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27909012
74Abnormality of polysaccharide metabolism (HP:0011012)2.27909012
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27909012
76Progressive inability to walk (HP:0002505)2.27700853
77Mucopolysacchariduria (HP:0008155)2.27328791
78Urinary glycosaminoglycan excretion (HP:0003541)2.27328791
79Hypsarrhythmia (HP:0002521)2.26287543
80Delusions (HP:0000746)2.24574958
81Abnormal social behavior (HP:0012433)2.24438240
82Impaired social interactions (HP:0000735)2.24438240
83Sleep apnea (HP:0010535)2.23410198
84Intention tremor (HP:0002080)2.22374687
85Congenital primary aphakia (HP:0007707)2.20462277
86Stridor (HP:0010307)2.19017397
87Torticollis (HP:0000473)2.18857586
88Hyperthyroidism (HP:0000836)2.18606716
89Mutism (HP:0002300)2.16600732
90Impaired smooth pursuit (HP:0007772)2.15341939
91Bradykinesia (HP:0002067)2.14975682
92Growth hormone excess (HP:0000845)2.14677501
93Abnormality of binocular vision (HP:0011514)2.11822293
94Diplopia (HP:0000651)2.11822293
95Medial flaring of the eyebrow (HP:0010747)2.11099600
96Excessive salivation (HP:0003781)2.10760252
97Drooling (HP:0002307)2.10760252
98Chronic otitis media (HP:0000389)2.09760189
99Ventricular fibrillation (HP:0001663)2.06766688
100Nephronophthisis (HP:0000090)2.06388778
101Fetal akinesia sequence (HP:0001989)2.06191749
102Absent speech (HP:0001344)2.05049818
103Generalized myoclonic seizures (HP:0002123)2.04726002
104Genetic anticipation (HP:0003743)2.04653014
105Focal dystonia (HP:0004373)2.02195727
106Type II lissencephaly (HP:0007260)2.01984054
107Megalencephaly (HP:0001355)2.01333492
108Central scotoma (HP:0000603)2.01170887
109Congenital stationary night blindness (HP:0007642)2.01169564
110Inability to walk (HP:0002540)2.01090862
111Nephrogenic diabetes insipidus (HP:0009806)2.00931605
112Cystic liver disease (HP:0006706)1.98089705
113Polyphagia (HP:0002591)1.97394897
114Peripheral hypomyelination (HP:0007182)1.94980472
115Genital tract atresia (HP:0001827)1.94659154
116Clonus (HP:0002169)1.94305328
117Specific learning disability (HP:0001328)1.93381683
118Vaginal atresia (HP:0000148)1.92813369
119Psychosis (HP:0000709)1.92464164
120Agitation (HP:0000713)1.92406671
121Impaired vibratory sensation (HP:0002495)1.89383135
122Decreased circulating renin level (HP:0003351)1.89097324
123Acute necrotizing encephalopathy (HP:0006965)1.87859883
124Hyperactive renin-angiotensin system (HP:0000841)1.87738156
125Annular pancreas (HP:0001734)1.87264552
126Abnormality of ocular smooth pursuit (HP:0000617)1.86961476
127True hermaphroditism (HP:0010459)1.86554584
128Dysostosis multiplex (HP:0000943)1.85916272
129Sensory axonal neuropathy (HP:0003390)1.85294222
130Stereotypic behavior (HP:0000733)1.84045355
131Craniofacial dystonia (HP:0012179)1.83688387
132Abnormal hair whorl (HP:0010721)1.82897491
133Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82161006
134Akinesia (HP:0002304)1.79536724
135Rigidity (HP:0002063)1.79336588
136Abnormality of saccadic eye movements (HP:0000570)1.79128422
137Abnormal mitochondria in muscle tissue (HP:0008316)1.77521445
138Abnormal EKG (HP:0003115)1.77494913
139Pancreatic fibrosis (HP:0100732)1.76693542
140Gait ataxia (HP:0002066)1.74406085
141Hypothermia (HP:0002045)1.73991345
142Chronic hepatic failure (HP:0100626)1.73548288
143Neuronal loss in central nervous system (HP:0002529)1.73520001
144Blue irides (HP:0000635)1.71814177
145Esotropia (HP:0000565)1.68959770
146Renal salt wasting (HP:0000127)1.67296671
147Prolonged QT interval (HP:0001657)1.66966908
148Spinal canal stenosis (HP:0003416)1.66656504
149Congenital malformation of the right heart (HP:0011723)1.63871068
150Double outlet right ventricle (HP:0001719)1.63871068
151Hypercortisolism (HP:0001578)1.63432651
152Nuclear cataract (HP:0100018)1.62985768
153Abnormality of renin-angiotensin system (HP:0000847)1.62216421
154Adrenal overactivity (HP:0002717)1.59008020
155J-shaped sella turcica (HP:0002680)1.57245548
156Abnormality of the aortic arch (HP:0012303)1.57047729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.27897496
2NTRK34.22291641
3EPHA43.77426591
4MAP3K93.10546339
5ARAF2.84191757
6MAP3K42.59144889
7CASK2.44011446
8MINK12.35664845
9MAP2K72.34941325
10NTRK12.15192458
11MAP3K122.14706369
12PRPF4B2.14001026
13MARK12.10244761
14MAP3K112.03740968
15DAPK21.96726282
16PAK61.95040539
17PRKD31.95006556
18EPHA21.94413600
19TNIK1.88928890
20TRIB31.85105090
21KSR21.78745385
22NTRK21.76485897
23TESK11.72406139
24PNCK1.67032525
25CDK191.65214282
26GRK51.63683674
27UHMK11.63453059
28OXSR11.63240887
29BCKDK1.59277904
30STK391.54916757
31MAP2K41.50257235
32MAPK131.49621781
33RIPK41.47931249
34CDK51.46555323
35ERN11.41287620
36PLK21.40995044
37MAP2K61.33782059
38INSRR1.30479600
39CAMKK11.26870950
40SGK4941.25911335
41SGK2231.25911335
42RIPK11.22482703
43PRKCG1.15571847
44CAMK2A1.12332143
45CAMKK21.12196341
46MAP3K131.11948883
47PINK11.11874936
48CAMK2B1.11368619
49FES1.10273881
50KSR11.08112073
51BCR1.07684392
52DAPK11.07124948
53PHKG21.05540451
54PHKG11.05540451
55PRKD21.04136499
56SMG11.00035142
57MAP3K20.99726779
58TYRO30.99709246
59DYRK1B0.96604976
60SIK10.96406138
61TAOK10.94340577
62PRKCH0.94334534
63RPS6KA20.93683064
64BRAF0.93563253
65CAMK2D0.90891269
66CDK140.89760214
67PIM20.89262861
68CDK180.88110710
69HIPK20.86913292
70WNK40.86132417
71EPHB10.85756181
72AKT30.85564342
73CDK150.85478483
74STK380.85422225
75ICK0.84702718
76PRKCE0.83465903
77RAF10.82708489
78WNK10.81014725
79EPHA30.80629628
80NEK60.78870890
81TNK20.78116561
82MAP2K20.77401350
83MAPKAPK50.77320774
84GRK60.74585746
85TBK10.74061933
86CDK11A0.73814638
87CAMK2G0.73798880
88CCNB10.73325107
89PAK30.72635913
90BMPR20.71862382
91FGR0.70959784
92MAP3K70.69365281
93SGK20.68764418
94CSNK1G20.68756150
95MAPK120.68454402
96CAMK10.68214860
97PTK2B0.67556960
98DYRK1A0.66625168
99MUSK0.65109736
100NME10.63131357
101MAP3K10.62494244
102LMTK20.61315675
103ROCK20.61030772
104PRKCI0.60881629
105PKN10.60637589
106MAPKAPK30.59658150
107GRK70.59172145
108CSNK1A1L0.58899891
109RET0.56913065
110STK110.55564924
111FGFR20.53776062
112PRKAA10.53271888
113SGK10.52129267
114FYN0.49752162
115MARK20.48006727
116PDPK10.47888584
117CDC42BPA0.47705810
118MAP3K60.47359983
119WNK30.47090406
120LIMK10.46899102
121CSNK1G30.46663098
122PRKD10.45935085
123ADRBK20.43091277
124CAMK40.42625094
125TLK10.42563308
126FER0.41759277
127SIK20.41499727
128PRKACA0.41485774
129SGK30.41311584
130MAPK100.41284981
131ADRBK10.40055906
132EEF2K0.37950009
133RPS6KA30.37806098
134PDK10.37803760
135DAPK30.36702202
136PRKCZ0.36616339
137PRKCA0.36591763

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.62274916
2Synaptic vesicle cycle_Homo sapiens_hsa047213.50092135
3GABAergic synapse_Homo sapiens_hsa047272.86325669
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80009458
5Olfactory transduction_Homo sapiens_hsa047402.75080235
6Circadian entrainment_Homo sapiens_hsa047132.66537536
7Morphine addiction_Homo sapiens_hsa050322.60222733
8Glutamatergic synapse_Homo sapiens_hsa047242.55360425
9Long-term potentiation_Homo sapiens_hsa047202.29892520
10Amphetamine addiction_Homo sapiens_hsa050312.29325208
11Collecting duct acid secretion_Homo sapiens_hsa049662.26046625
12Insulin secretion_Homo sapiens_hsa049112.21502069
13Dopaminergic synapse_Homo sapiens_hsa047282.19332748
14Taste transduction_Homo sapiens_hsa047422.14273084
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05805157
16Phototransduction_Homo sapiens_hsa047442.01118558
17Serotonergic synapse_Homo sapiens_hsa047261.98206730
18Salivary secretion_Homo sapiens_hsa049701.96756494
19Cholinergic synapse_Homo sapiens_hsa047251.93496557
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.70269791
21Gastric acid secretion_Homo sapiens_hsa049711.66770332
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66208185
23Cocaine addiction_Homo sapiens_hsa050301.64981507
24Long-term depression_Homo sapiens_hsa047301.59397416
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54763654
26Oxidative phosphorylation_Homo sapiens_hsa001901.53749399
27Renin secretion_Homo sapiens_hsa049241.52875089
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51353085
29Cardiac muscle contraction_Homo sapiens_hsa042601.47945519
30Vibrio cholerae infection_Homo sapiens_hsa051101.47744044
31Calcium signaling pathway_Homo sapiens_hsa040201.46125188
32Oxytocin signaling pathway_Homo sapiens_hsa049211.41674410
33Phenylalanine metabolism_Homo sapiens_hsa003601.39365625
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25733662
35Alzheimers disease_Homo sapiens_hsa050101.23139926
36GnRH signaling pathway_Homo sapiens_hsa049121.19637673
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18440455
38Gap junction_Homo sapiens_hsa045401.17777463
39Histidine metabolism_Homo sapiens_hsa003401.17196204
40Parkinsons disease_Homo sapiens_hsa050121.16831974
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13286868
42cAMP signaling pathway_Homo sapiens_hsa040241.11064414
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05848611
44Axon guidance_Homo sapiens_hsa043601.04777956
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03399452
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99894512
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.99549895
48Type II diabetes mellitus_Homo sapiens_hsa049300.98590049
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98502585
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98017643
51Other glycan degradation_Homo sapiens_hsa005110.94310431
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93489682
53Lysosome_Homo sapiens_hsa041420.90339492
54Notch signaling pathway_Homo sapiens_hsa043300.89835850
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89696134
56Estrogen signaling pathway_Homo sapiens_hsa049150.89447740
57beta-Alanine metabolism_Homo sapiens_hsa004100.89139288
58Vitamin B6 metabolism_Homo sapiens_hsa007500.86033331
59Pancreatic secretion_Homo sapiens_hsa049720.85475464
60Melanogenesis_Homo sapiens_hsa049160.85407088
61ErbB signaling pathway_Homo sapiens_hsa040120.84982454
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82841130
63Bile secretion_Homo sapiens_hsa049760.77961559
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.76245979
65Huntingtons disease_Homo sapiens_hsa050160.74121539
66ABC transporters_Homo sapiens_hsa020100.69342756
67Glioma_Homo sapiens_hsa052140.68792464
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.68705707
69Dorso-ventral axis formation_Homo sapiens_hsa043200.68298334
70Thyroid hormone synthesis_Homo sapiens_hsa049180.67741275
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67580380
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67426513
73Tyrosine metabolism_Homo sapiens_hsa003500.66925270
74Dilated cardiomyopathy_Homo sapiens_hsa054140.66242427
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.65596314
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64588273
77Oocyte meiosis_Homo sapiens_hsa041140.63384205
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62229143
79Peroxisome_Homo sapiens_hsa041460.61341166
80Type I diabetes mellitus_Homo sapiens_hsa049400.60692520
81Chemical carcinogenesis_Homo sapiens_hsa052040.59721637
82Ras signaling pathway_Homo sapiens_hsa040140.59522995
83Alcoholism_Homo sapiens_hsa050340.58892934
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54417766
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53301828
86Choline metabolism in cancer_Homo sapiens_hsa052310.52598253
87Fatty acid elongation_Homo sapiens_hsa000620.52249435
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.52030599
89MAPK signaling pathway_Homo sapiens_hsa040100.51958052
90Rheumatoid arthritis_Homo sapiens_hsa053230.51352864
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50286985
92Inositol phosphate metabolism_Homo sapiens_hsa005620.49704617
93Ether lipid metabolism_Homo sapiens_hsa005650.48332090
94Circadian rhythm_Homo sapiens_hsa047100.47071290
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46281959
96Butanoate metabolism_Homo sapiens_hsa006500.45872504
97Sulfur relay system_Homo sapiens_hsa041220.42447092
98Regulation of autophagy_Homo sapiens_hsa041400.41568663
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41372846
100Glucagon signaling pathway_Homo sapiens_hsa049220.41120950
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40796090
102Endocytosis_Homo sapiens_hsa041440.40737754
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40186509
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.39952364
105mTOR signaling pathway_Homo sapiens_hsa041500.39498303
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39422954
107Arginine and proline metabolism_Homo sapiens_hsa003300.39242212
108Prion diseases_Homo sapiens_hsa050200.39159061
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35236329
110Sphingolipid metabolism_Homo sapiens_hsa006000.35150191
111Ovarian steroidogenesis_Homo sapiens_hsa049130.33856318
112Renal cell carcinoma_Homo sapiens_hsa052110.32051203
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30971789
114Rap1 signaling pathway_Homo sapiens_hsa040150.30963820
115VEGF signaling pathway_Homo sapiens_hsa043700.30388325
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.28717662
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27798323
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27467654
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27336392
120Mineral absorption_Homo sapiens_hsa049780.27035805
121Wnt signaling pathway_Homo sapiens_hsa043100.26911921
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22542775
123Phagosome_Homo sapiens_hsa041450.22425806

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