PA2G4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)4.84485453
2DNA strand elongation involved in DNA replication (GO:0006271)4.74166059
3establishment of integrated proviral latency (GO:0075713)4.72314878
4DNA unwinding involved in DNA replication (GO:0006268)4.64197566
5purine nucleobase biosynthetic process (GO:0009113)4.63192944
6DNA replication initiation (GO:0006270)4.59136720
7formation of translation preinitiation complex (GO:0001731)4.55338194
8protein localization to kinetochore (GO:0034501)4.54416978
9DNA strand elongation (GO:0022616)4.51778702
10maturation of SSU-rRNA (GO:0030490)4.44251440
11mitotic metaphase plate congression (GO:0007080)4.43073658
12DNA replication checkpoint (GO:0000076)4.34964322
13ribosome assembly (GO:0042255)4.34114473
14IMP biosynthetic process (GO:0006188)4.30394192
15telomere maintenance via semi-conservative replication (GO:0032201)4.25759563
16mitotic nuclear envelope disassembly (GO:0007077)4.25394762
17nuclear pore organization (GO:0006999)4.19440874
18regulation of translational fidelity (GO:0006450)4.17358901
19folic acid-containing compound biosynthetic process (GO:0009396)4.16866906
20ribosome biogenesis (GO:0042254)4.11727914
21nuclear pore complex assembly (GO:0051292)3.96219417
22ribosomal small subunit assembly (GO:0000028)3.94974141
23membrane disassembly (GO:0030397)3.93734821
24nuclear envelope disassembly (GO:0051081)3.93734821
25protein localization to chromosome, centromeric region (GO:0071459)3.85115438
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.83384582
27telomere maintenance via recombination (GO:0000722)3.83240490
28ribonucleoprotein complex biogenesis (GO:0022613)3.82760828
29IMP metabolic process (GO:0046040)3.78307923
30DNA replication-dependent nucleosome assembly (GO:0006335)3.77578683
31DNA replication-dependent nucleosome organization (GO:0034723)3.77578683
32ribosomal large subunit biogenesis (GO:0042273)3.77560878
33regulation of spindle organization (GO:0090224)3.75637547
34metaphase plate congression (GO:0051310)3.75240929
35mitotic recombination (GO:0006312)3.70456609
36establishment of viral latency (GO:0019043)3.68916815
37CENP-A containing nucleosome assembly (GO:0034080)3.67131257
38nucleobase-containing small molecule interconversion (GO:0015949)3.66949653
39chromatin remodeling at centromere (GO:0031055)3.64100462
40DNA topological change (GO:0006265)3.57757861
41telomere maintenance via telomere lengthening (GO:0010833)3.57637479
42spliceosomal snRNP assembly (GO:0000387)3.49125010
43DNA replication-independent nucleosome assembly (GO:0006336)3.47840680
44DNA replication-independent nucleosome organization (GO:0034724)3.47840680
45* rRNA processing (GO:0006364)3.46774206
46mitotic sister chromatid segregation (GO:0000070)3.45726110
47translational initiation (GO:0006413)3.43650828
48translational termination (GO:0006415)3.43198518
49viral transcription (GO:0019083)3.42563143
50kinetochore organization (GO:0051383)3.41033953
51folic acid metabolic process (GO:0046655)3.38770000
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.37482622
53positive regulation of chromosome segregation (GO:0051984)3.36503114
54cotranslational protein targeting to membrane (GO:0006613)3.35994165
55* rRNA metabolic process (GO:0016072)3.35539790
56protein targeting to ER (GO:0045047)3.34046525
57ribosomal small subunit biogenesis (GO:0042274)3.33424491
58establishment of chromosome localization (GO:0051303)3.32714813
59heterochromatin organization (GO:0070828)3.32485740
60regulation of mitochondrial translation (GO:0070129)3.30191654
61attachment of spindle microtubules to kinetochore (GO:0008608)3.29706440
62nucleotide-excision repair, DNA gap filling (GO:0006297)3.28260773
63negative regulation of RNA splicing (GO:0033119)3.27189200
64DNA deamination (GO:0045006)3.26488684
65mitotic chromosome condensation (GO:0007076)3.26280028
66mitotic sister chromatid cohesion (GO:0007064)3.23751469
67DNA duplex unwinding (GO:0032508)3.21677821
68negative regulation of mRNA processing (GO:0050686)3.21462032
69establishment of protein localization to endoplasmic reticulum (GO:0072599)3.21362291
70translational elongation (GO:0006414)3.21352670
71DNA geometric change (GO:0032392)3.19662595
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17421597
73sister chromatid segregation (GO:0000819)3.16714761
74regulation of mitotic spindle organization (GO:0060236)3.16607702
75DNA ligation (GO:0006266)3.14680300
76viral mRNA export from host cell nucleus (GO:0046784)3.14556256
77histone exchange (GO:0043486)3.13625324
78pseudouridine synthesis (GO:0001522)3.12566796
79translation (GO:0006412)3.12160031
80protein localization to endoplasmic reticulum (GO:0070972)3.11804116
81nuclear envelope organization (GO:0006998)3.11792425
82pore complex assembly (GO:0046931)3.11162086
83cellular protein complex disassembly (GO:0043624)3.11088245
84protein complex localization (GO:0031503)3.09846909
85tRNA aminoacylation for protein translation (GO:0006418)3.09815398
86viral life cycle (GO:0019058)3.09082965
87spindle checkpoint (GO:0031577)3.08434939
88nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.07851354
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.07285785
90rRNA modification (GO:0000154)3.07098648
91tRNA aminoacylation (GO:0043039)3.05205151
92amino acid activation (GO:0043038)3.05205151
93negative regulation of chromosome segregation (GO:0051985)3.05061297
94kinetochore assembly (GO:0051382)3.04933529
95negative regulation of ligase activity (GO:0051352)3.04441043
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04441043
97cellular component biogenesis (GO:0044085)3.03969925
98chromosome condensation (GO:0030261)3.03299801
99regulation of chromosome segregation (GO:0051983)3.02281441
100negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01490704
101negative regulation of sister chromatid segregation (GO:0033046)3.01490704
102negative regulation of mitotic sister chromatid separation (GO:2000816)3.01490704
103negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01490704
104RNA splicing, via transesterification reactions (GO:0000375)3.00059301
105somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98792872
106somatic hypermutation of immunoglobulin genes (GO:0016446)2.98792872
107spindle assembly checkpoint (GO:0071173)2.98450713
108mRNA splicing, via spliceosome (GO:0000398)2.98379353
109RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.98379353
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98200829
111cell cycle G1/S phase transition (GO:0044843)2.97944811
112G1/S transition of mitotic cell cycle (GO:0000082)2.97944811
113regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97242023
114maturation of 5.8S rRNA (GO:0000460)2.97179706
115transcription-coupled nucleotide-excision repair (GO:0006283)2.97135396
116mitotic spindle assembly checkpoint (GO:0007094)2.96874833
117mitotic spindle checkpoint (GO:0071174)2.96757074
118non-recombinational repair (GO:0000726)2.96565416
119double-strand break repair via nonhomologous end joining (GO:0006303)2.96565416
120negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96349863
121negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95041096
122negative regulation of mRNA metabolic process (GO:1903312)2.94692617
123chromosome segregation (GO:0007059)2.94474841
124regulation of centrosome cycle (GO:0046605)2.94367762
125spliceosomal complex assembly (GO:0000245)2.94307727
126protein complex disassembly (GO:0043241)2.94039267
127peptidyl-arginine omega-N-methylation (GO:0035247)2.92763104
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92477605
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91667386
130regulation of translational termination (GO:0006449)2.90695360
131regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89747838
132proteasome assembly (GO:0043248)2.89417480
133SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87496948
134chromatin assembly or disassembly (GO:0006333)2.86879493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.84180180
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.40548364
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.05507558
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77397730
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.70019526
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15737992
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11301695
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98155771
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88579062
10* EST1_17652178_ChIP-ChIP_JURKAT_Human2.87156803
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82355496
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.77738915
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.69329745
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67818539
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65593301
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37149341
17* XRN2_22483619_ChIP-Seq_HELA_Human2.35507359
18AR_21909140_ChIP-Seq_LNCAP_Human2.32308802
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23271586
20VDR_23849224_ChIP-Seq_CD4+_Human2.15387693
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.15348374
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14114732
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13599699
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06331872
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.02193078
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94812552
27FOXP3_21729870_ChIP-Seq_TREG_Human1.92328466
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92010547
29DCP1A_22483619_ChIP-Seq_HELA_Human1.90138558
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89555518
31* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87478872
32GABP_19822575_ChIP-Seq_HepG2_Human1.84834746
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81277346
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78724714
35* TTF2_22483619_ChIP-Seq_HELA_Human1.77747817
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75723633
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74983222
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72966394
39* MYC_22102868_ChIP-Seq_BL_Human1.71599624
40* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70313602
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61442143
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59775357
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59510972
44CIITA_25753668_ChIP-Seq_RAJI_Human1.58902136
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57152244
46ZNF263_19887448_ChIP-Seq_K562_Human1.55185553
47ELK1_19687146_ChIP-ChIP_HELA_Human1.54865125
48* KDM5A_27292631_Chip-Seq_BREAST_Human1.53689690
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50447262
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48763682
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46915834
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.45344896
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40662748
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36459725
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33431932
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30770205
57* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30477350
58* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27394528
59* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26771761
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24457377
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23095032
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21928510
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20183333
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.19868268
65* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17116389
66* SRF_21415370_ChIP-Seq_HL-1_Mouse1.16915606
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16283335
68* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15252173
69TFEB_21752829_ChIP-Seq_HELA_Human1.13992079
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12815729
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11451427
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09136042
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.08216302
74* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06132818
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05098243
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04598012
77* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03114601
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02072412
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01074388
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98630881
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97204348
82CHD1_26751641_Chip-Seq_LNCaP_Human0.96561930
83VDR_21846776_ChIP-Seq_THP-1_Human0.96496486
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96468742
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96125482
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94755751
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93810982
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93531325
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92867927
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90739004
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90715498
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.89764394
93MYC_18940864_ChIP-ChIP_HL60_Human0.89695000
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88407471
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87019609
96TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86820920
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.86669070
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85038809
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.84676161
100* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83936941
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83158890
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82212130
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82200698
104* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82092630
105SPI1_23547873_ChIP-Seq_NB4_Human0.81401372
106ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81220590
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81095288
108TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81094598
109SALL1_21062744_ChIP-ChIP_HESCs_Human0.78250836
110* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77131231
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76460342
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75909629
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.74504736
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74364956
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74115152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.67877344
2MP0010094_abnormal_chromosome_stability4.74198321
3MP0003111_abnormal_nucleus_morphology4.67219728
4MP0004957_abnormal_blastocyst_morpholog4.62791430
5MP0003077_abnormal_cell_cycle4.08976907
6MP0008057_abnormal_DNA_replication4.05757758
7MP0008058_abnormal_DNA_repair3.28809124
8MP0008932_abnormal_embryonic_tissue2.68649922
9MP0001730_embryonic_growth_arrest2.65120362
10MP0002396_abnormal_hematopoietic_system2.63023315
11* MP0008007_abnormal_cellular_replicative2.51142905
12MP0010352_gastrointestinal_tract_polyps2.50977383
13* MP0000350_abnormal_cell_proliferation2.35171488
14MP0003123_paternal_imprinting2.34195341
15MP0003786_premature_aging2.04996625
16MP0010307_abnormal_tumor_latency2.04788692
17MP0002877_abnormal_melanocyte_morpholog1.94996258
18MP0001672_abnormal_embryogenesis/_devel1.94062329
19MP0005380_embryogenesis_phenotype1.94062329
20MP0009379_abnormal_foot_pigmentation1.93134764
21MP0009697_abnormal_copulation1.87329951
22MP0001697_abnormal_embryo_size1.86396098
23MP0003984_embryonic_growth_retardation1.76591627
24MP0008877_abnormal_DNA_methylation1.76477389
25MP0002080_prenatal_lethality1.74942543
26MP0000490_abnormal_crypts_of1.74778997
27MP0002088_abnormal_embryonic_growth/wei1.72384335
28MP0003718_maternal_effect1.70177540
29MP0004233_abnormal_muscle_weight1.66999794
30MP0002085_abnormal_embryonic_tissue1.62536779
31MP0002796_impaired_skin_barrier1.60247275
32MP0006035_abnormal_mitochondrial_morpho1.54861485
33MP0002084_abnormal_developmental_patter1.54715105
34MP0002086_abnormal_extraembryonic_tissu1.51065794
35MP0004197_abnormal_fetal_growth/weight/1.50822335
36MP0003806_abnormal_nucleotide_metabolis1.48303645
37MP0004185_abnormal_adipocyte_glucose1.47937939
38MP0000313_abnormal_cell_death1.47525902
39MP0004808_abnormal_hematopoietic_stem1.47510608
40MP0003567_abnormal_fetal_cardiomyocyte1.46652319
41MP0002019_abnormal_tumor_incidence1.43694264
42MP0009333_abnormal_splenocyte_physiolog1.42263409
43MP0005076_abnormal_cell_differentiation1.40729677
44MP0010030_abnormal_orbit_morphology1.34421582
45MP0006036_abnormal_mitochondrial_physio1.33809009
46MP0005397_hematopoietic_system_phenotyp1.26139211
47MP0001545_abnormal_hematopoietic_system1.26139211
48MP0009053_abnormal_anal_canal1.21181607
49MP0001293_anophthalmia1.19438102
50MP0005451_abnormal_body_composition1.16570309
51MP0000678_abnormal_parathyroid_gland1.13480634
52MP0010234_abnormal_vibrissa_follicle1.13362318
53MP0003315_abnormal_perineum_morphology1.10659040
54MP0003890_abnormal_embryonic-extraembry1.06182013
55MP0009672_abnormal_birth_weight1.05422898
56MP0001346_abnormal_lacrimal_gland1.05342390
57MP0000703_abnormal_thymus_morphology1.03987383
58MP0002210_abnormal_sex_determination1.03955923
59MP0001661_extended_life_span1.01935258
60MP0003121_genomic_imprinting1.01763816
61MP0000537_abnormal_urethra_morphology1.01727501
62MP0003763_abnormal_thymus_physiology0.99566219
63MP0003221_abnormal_cardiomyocyte_apopto0.99045406
64MP0001727_abnormal_embryo_implantation0.97927797
65MP0001145_abnormal_male_reproductive0.95693282
66MP0003705_abnormal_hypodermis_morpholog0.94900989
67MP0001881_abnormal_mammary_gland0.93857191
68MP0000358_abnormal_cell_content/0.93738991
69MP0002722_abnormal_immune_system0.92843532
70MP0002398_abnormal_bone_marrow0.92377764
71MP0008995_early_reproductive_senescence0.91985468
72MP0002697_abnormal_eye_size0.89331742
73MP0003941_abnormal_skin_development0.87634438
74MP0000579_abnormal_nail_morphology0.86799534
75MP0006054_spinal_hemorrhage0.86667127
76MP0000689_abnormal_spleen_morphology0.86224711
77MP0005384_cellular_phenotype0.85765628
78MP0003566_abnormal_cell_adhesion0.84340482
79MP0003119_abnormal_digestive_system0.84037973
80MP0003186_abnormal_redox_activity0.83995108
81MP0005023_abnormal_wound_healing0.83651203
82MP0005621_abnormal_cell_physiology0.83588730
83MP0000858_altered_metastatic_potential0.83166050
84MP0002160_abnormal_reproductive_system0.80250818
85MP0000653_abnormal_sex_gland0.79301418
86MP0009703_decreased_birth_body0.76197879
87MP0005408_hypopigmentation0.76120059
88MP0003937_abnormal_limbs/digits/tail_de0.75649720
89MP0000428_abnormal_craniofacial_morphol0.75292993
90MP0001915_intracranial_hemorrhage0.75192969
91* MP0002111_abnormal_tail_morphology0.75164622
92MP0001929_abnormal_gametogenesis0.75075413
93MP0002132_abnormal_respiratory_system0.72954797
94MP0002429_abnormal_blood_cell0.72129663
95MP0004264_abnormal_extraembryonic_tissu0.70342690
96MP0000762_abnormal_tongue_morphology0.69227577
97MP0002092_abnormal_eye_morphology0.68624909
98MP0001216_abnormal_epidermal_layer0.67761104
99MP0005389_reproductive_system_phenotype0.67479608
100MP0001119_abnormal_female_reproductive0.67271851
101MP0000477_abnormal_intestine_morphology0.66971149
102MP0000566_synostosis0.66773892
103MP0005501_abnormal_skin_physiology0.66016312
104MP0002060_abnormal_skin_morphology0.65611930
105MP0001849_ear_inflammation0.64827200
106MP0009278_abnormal_bone_marrow0.64583473
107MP0000750_abnormal_muscle_regeneration0.64225304
108MP0001286_abnormal_eye_development0.62580907
109MP0002098_abnormal_vibrissa_morphology0.60797133
110MP0002234_abnormal_pharynx_morphology0.59406500
111MP0002653_abnormal_ependyma_morphology0.59181613
112MP0003699_abnormal_female_reproductive0.58229352
113MP0002269_muscular_atrophy0.57756086
114MP0003385_abnormal_body_wall0.57126837
115MP0001853_heart_inflammation0.56553602
116MP0000627_abnormal_mammary_gland0.56067172
117MP0004133_heterotaxia0.55858154
118MP0009931_abnormal_skin_appearance0.55410990
119MP0000716_abnormal_immune_system0.54755725
120MP0001529_abnormal_vocalization0.54575468
121MP0003942_abnormal_urinary_system0.54161052
122MP0001873_stomach_inflammation0.54045357
123MP0002163_abnormal_gland_morphology0.54033739
124MP0008770_decreased_survivor_rate0.53052882
125MP0000733_abnormal_muscle_development0.52527016
126MP0000432_abnormal_head_morphology0.52244669
127MP0006292_abnormal_olfactory_placode0.51229418
128MP0003448_altered_tumor_morphology0.49119692
129MP0001919_abnormal_reproductive_system0.48063120
130MP0003115_abnormal_respiratory_system0.47106879
131MP0001243_abnormal_dermal_layer0.46472314
132MP0003936_abnormal_reproductive_system0.46455242
133MP0000465_gastrointestinal_hemorrhage0.46157507

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.18176065
2Breast hypoplasia (HP:0003187)3.99172801
3Reticulocytopenia (HP:0001896)3.94782575
4Oral leukoplakia (HP:0002745)3.78261650
5Microvesicular hepatic steatosis (HP:0001414)3.72784318
6Abnormality of cells of the erythroid lineage (HP:0012130)3.61406896
7Selective tooth agenesis (HP:0001592)3.58029559
8Chromsome breakage (HP:0040012)3.49129437
9Abnormality of the anterior horn cell (HP:0006802)3.48987139
10Degeneration of anterior horn cells (HP:0002398)3.48987139
11Abnormal number of erythroid precursors (HP:0012131)3.46832184
12Ependymoma (HP:0002888)3.35134726
13Patellar aplasia (HP:0006443)3.33779935
14Rough bone trabeculation (HP:0100670)3.31412483
15Abnormality of glycolysis (HP:0004366)3.29832748
16Carpal bone hypoplasia (HP:0001498)3.27556432
17Colon cancer (HP:0003003)3.24370541
18Medulloblastoma (HP:0002885)3.19587877
19Aplasia/Hypoplasia of the patella (HP:0006498)3.17083803
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15047408
21Abnormality of chromosome stability (HP:0003220)3.06767467
22Cerebral hypomyelination (HP:0006808)3.04274746
23Increased serum pyruvate (HP:0003542)3.04254712
24Aplastic anemia (HP:0001915)3.03714774
25Aplasia/Hypoplasia of the sacrum (HP:0008517)3.03368973
26Impulsivity (HP:0100710)3.02045995
27Abnormality of the preputium (HP:0100587)2.97462213
28Meckel diverticulum (HP:0002245)2.93928175
29Abnormality of the ileum (HP:0001549)2.79090555
30Macrocytic anemia (HP:0001972)2.77345717
31Abnormality of the labia minora (HP:0012880)2.74720990
32Trismus (HP:0000211)2.74155005
33Abnormal mitochondria in muscle tissue (HP:0008316)2.67427840
34Agnosia (HP:0010524)2.66970754
35Absent thumb (HP:0009777)2.66372462
36Absent radius (HP:0003974)2.63702959
37Multiple enchondromatosis (HP:0005701)2.63031101
38Myelodysplasia (HP:0002863)2.58739199
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.57083558
40Acute necrotizing encephalopathy (HP:0006965)2.55989826
41Rhabdomyosarcoma (HP:0002859)2.55590639
42Neoplasm of the pancreas (HP:0002894)2.54888435
43Abnormality of reticulocytes (HP:0004312)2.52228322
44Premature graying of hair (HP:0002216)2.50518832
45Increased hepatocellular lipid droplets (HP:0006565)2.50017828
46Proximal placement of thumb (HP:0009623)2.49351125
47Cholecystitis (HP:0001082)2.47915393
48Abnormal gallbladder physiology (HP:0012438)2.47915393
49Microretrognathia (HP:0000308)2.44844320
50Aplasia involving forearm bones (HP:0009822)2.43077813
51Absent forearm bone (HP:0003953)2.43077813
52Acute encephalopathy (HP:0006846)2.42444077
53Deviation of the thumb (HP:0009603)2.42319278
54Septate vagina (HP:0001153)2.42301571
55Duodenal stenosis (HP:0100867)2.41988089
56Small intestinal stenosis (HP:0012848)2.41988089
57Bone marrow hypocellularity (HP:0005528)2.41163464
58Pallor (HP:0000980)2.39782322
59Atresia of the external auditory canal (HP:0000413)2.36022308
60Basal cell carcinoma (HP:0002671)2.34243765
61Abnormal trabecular bone morphology (HP:0100671)2.33817000
62Ragged-red muscle fibers (HP:0003200)2.33733438
63Abnormal number of incisors (HP:0011064)2.33410122
64Progressive external ophthalmoplegia (HP:0000590)2.30453246
6511 pairs of ribs (HP:0000878)2.28297804
66Horseshoe kidney (HP:0000085)2.26814074
67Squamous cell carcinoma (HP:0002860)2.25306186
68Lipid accumulation in hepatocytes (HP:0006561)2.23598076
69Increased CSF lactate (HP:0002490)2.21820519
70Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21386109
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21386109
72Increased serum lactate (HP:0002151)2.21095714
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19911979
74Secondary amenorrhea (HP:0000869)2.19809402
75Ectopic kidney (HP:0000086)2.18461391
76Increased nuchal translucency (HP:0010880)2.17452540
77Sloping forehead (HP:0000340)2.17262488
78Glossoptosis (HP:0000162)2.15289475
79Premature ovarian failure (HP:0008209)2.15090922
80Cellular immunodeficiency (HP:0005374)2.12141843
81Tracheoesophageal fistula (HP:0002575)2.11881588
82Abnormality of cochlea (HP:0000375)2.10863114
83Pancytopenia (HP:0001876)2.09444409
84Thrombocytosis (HP:0001894)2.08435995
85Nephroblastoma (Wilms tumor) (HP:0002667)2.06128894
86Atrophy/Degeneration involving motor neurons (HP:0007373)2.05528409
87Cortical dysplasia (HP:0002539)2.05502542
88Increased intramyocellular lipid droplets (HP:0012240)2.05470070
89Glioma (HP:0009733)2.03714031
90Cerebral edema (HP:0002181)2.02867813
91Entropion (HP:0000621)2.01134624
92Mitochondrial inheritance (HP:0001427)2.00197248
93Abnormality of the astrocytes (HP:0100707)2.00112464
94Astrocytoma (HP:0009592)2.00112464
95Megaloblastic anemia (HP:0001889)1.99504938
96Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99463851
97Prominent nose (HP:0000448)1.99323008
98Abnormality of the umbilical cord (HP:0010881)1.99101267
99Slender long bone (HP:0003100)1.98594838
100Abnormality of the duodenum (HP:0002246)1.96598431
101Amaurosis fugax (HP:0100576)1.95684607
102Abnormal lung lobation (HP:0002101)1.95485264
103Overlapping toe (HP:0001845)1.95146269
104Triphalangeal thumb (HP:0001199)1.94464653
105Cafe-au-lait spot (HP:0000957)1.94220741
106Cleft eyelid (HP:0000625)1.93991579
107Exercise intolerance (HP:0003546)1.93841265
108Abnormality of the calcaneus (HP:0008364)1.91776347
109Abnormality of methionine metabolism (HP:0010901)1.91695585
110Facial hemangioma (HP:0000329)1.91236036
111Respiratory difficulties (HP:0002880)1.90563422
112Sparse lateral eyebrow (HP:0005338)1.89590651
113Choanal atresia (HP:0000453)1.89455013
114Hepatocellular necrosis (HP:0001404)1.89419661
115Embryonal renal neoplasm (HP:0011794)1.89385987
116Lymphoma (HP:0002665)1.89004094
117Gout (HP:0001997)1.88618981
118Sparse eyelashes (HP:0000653)1.87934349
119Aplasia/Hypoplasia of the sternum (HP:0006714)1.87934149
120Abnormality of the carotid arteries (HP:0005344)1.85381548
121Supernumerary spleens (HP:0009799)1.84211956
122Short thumb (HP:0009778)1.84029971
123Spinal muscular atrophy (HP:0007269)1.83722655
124Insomnia (HP:0100785)1.83711614
125Neoplasm of striated muscle (HP:0009728)1.83134095
126Facial cleft (HP:0002006)1.82232353
127Ureteral duplication (HP:0000073)1.81462162
128Volvulus (HP:0002580)1.80688439
129Missing ribs (HP:0000921)1.80141241
130Lactic acidosis (HP:0003128)1.80018310
131Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78799948
132Progressive macrocephaly (HP:0004481)1.78045127
133Reduced antithrombin III activity (HP:0001976)1.76867224
134Testicular atrophy (HP:0000029)1.76408451
135Duplication of thumb phalanx (HP:0009942)1.75861689
136Biliary tract neoplasm (HP:0100574)1.74171040
137Progressive muscle weakness (HP:0003323)1.74051387
138CNS hypomyelination (HP:0003429)1.73852905
139Pelvic girdle muscle weakness (HP:0003749)1.73824920
140Aplasia/hypoplasia of the humerus (HP:0006507)1.73391122
141Neoplasm of the colon (HP:0100273)1.72825475
142Abnormality of pyrimidine metabolism (HP:0004353)1.72584262
143Short middle phalanx of the 5th finger (HP:0004220)1.72444222
144Type I transferrin isoform profile (HP:0003642)1.71220228
145Abnormality of the fetal cardiovascular system (HP:0010948)1.71107502
146Abnormal umbilical cord blood vessels (HP:0011403)1.71107502
147Single umbilical artery (HP:0001195)1.71107502
148Increased muscle lipid content (HP:0009058)1.68945696
149Abnormalities of placenta or umbilical cord (HP:0001194)1.68473225
150Poikiloderma (HP:0001029)1.67656912
151Hyperacusis (HP:0010780)1.67549819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.78529255
2WEE14.36904102
3CDC73.99538593
4EIF2AK13.63013981
5VRK23.62055750
6TSSK63.25070763
7NEK22.60706325
8SMG12.50793680
9SRPK12.50488104
10NEK12.49707691
11TTK2.27891123
12BRSK22.14808518
13MKNK12.07114165
14EIF2AK32.07000016
15PLK42.04586694
16NME21.96321342
17PLK11.96128042
18TESK21.93356612
19ACVR1B1.86281408
20PLK31.81012450
21RPS6KB21.75063115
22MKNK21.72085979
23CDK71.72048096
24PASK1.68766107
25AURKB1.67858285
26CDK121.65906525
27EPHA21.64964171
28EEF2K1.64239863
29ATR1.64235192
30STK161.56716680
31RPS6KA41.50852204
32TAF11.47805256
33VRK11.43766360
34CDK41.41652666
35MAP3K81.36703259
36BRSK11.35530677
37CHEK21.35006388
38DYRK31.33258614
39CHEK11.30390177
40STK101.29177215
41ICK1.25458022
42IRAK31.25185066
43TLK11.18989003
44MST41.18540787
45AURKA1.18204283
46ALK1.10105707
47SCYL21.06142555
48PAK41.05133882
49TGFBR11.04903947
50PIM21.01204285
51MST1R0.99679654
52CCNB10.97913003
53STK40.90767176
54CDK20.89653265
55ATM0.88283045
56ZAK0.87020672
57CDK60.83136354
58PIM10.82447375
59MAP3K100.81606415
60STK30.78974835
61PNCK0.77189502
62LRRK20.76591105
63PDK20.74301405
64PKN20.71878237
65TESK10.71782543
66* CSNK2A20.71489304
67CSNK2A10.66788180
68CDK10.64521133
69MAP4K10.62462696
70CDK80.62096082
71LATS20.61001208
72BRD40.60051188
73FLT30.59725604
74EIF2AK20.58238488
75MAP2K30.56424042
76ARAF0.55879425
77DAPK10.55462985
78PRKCI0.55344732
79KDR0.54753909
80MAP3K110.53533003
81PRPF4B0.53392595
82* PAK10.52601071
83MTOR0.51052989
84CSNK1E0.48257698
85STK38L0.48245037
86ERBB40.47331233
87MAP3K90.46910174
88PAK20.45794981
89RAF10.43879831
90CDK90.43132459
91MELK0.41674332
92CDK11A0.41573090
93MAP3K30.40731781
94NME10.39013959
95AKT20.37851160
96CDK150.37753404
97CDK140.37457482
98CDK180.35732971
99AKT30.35574131
100PRKDC0.35379514
101MAPKAPK30.34729690
102BRAF0.33526282
103TAOK20.33362374
104NUAK10.33125333
105PBK0.32455874
106RPS6KA50.32296737
107BTK0.31996970
108KSR20.30408405
109MAPKAPK50.29513927
110ILK0.29126016
111FGFR10.29018816
112PDK30.28944415
113PDK40.28944415
114LATS10.27658988
115BCKDK0.27093138
116CLK10.26578691
117LIMK10.25622241
118CSNK1G30.25095475
119MAPK110.24917935
120DMPK0.24891862
121MAPK140.24167112
122TRIB30.23053546
123TEC0.22503281
124ZAP700.22438858
125NEK90.21252188

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.87283814
2Mismatch repair_Homo sapiens_hsa034304.10199402
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.98042030
4RNA transport_Homo sapiens_hsa030133.35880819
5Spliceosome_Homo sapiens_hsa030403.35458999
6RNA polymerase_Homo sapiens_hsa030203.35344050
7Proteasome_Homo sapiens_hsa030503.22690624
8Ribosome_Homo sapiens_hsa030103.17133147
9One carbon pool by folate_Homo sapiens_hsa006702.94883171
10Homologous recombination_Homo sapiens_hsa034402.89213443
11Base excision repair_Homo sapiens_hsa034102.88210634
12Cell cycle_Homo sapiens_hsa041102.79024143
13Nucleotide excision repair_Homo sapiens_hsa034202.78248344
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.61996048
15Pyrimidine metabolism_Homo sapiens_hsa002402.43430366
16Fanconi anemia pathway_Homo sapiens_hsa034602.05519983
17Non-homologous end-joining_Homo sapiens_hsa034501.96118812
18RNA degradation_Homo sapiens_hsa030181.81407625
19Basal transcription factors_Homo sapiens_hsa030221.79174375
20mRNA surveillance pathway_Homo sapiens_hsa030151.74508494
21p53 signaling pathway_Homo sapiens_hsa041151.66901444
22Vitamin B6 metabolism_Homo sapiens_hsa007501.46866922
23Parkinsons disease_Homo sapiens_hsa050121.45742147
24Oxidative phosphorylation_Homo sapiens_hsa001901.39567210
25Pyruvate metabolism_Homo sapiens_hsa006201.34147243
26Purine metabolism_Homo sapiens_hsa002301.28408982
27Epstein-Barr virus infection_Homo sapiens_hsa051691.27012854
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.09544869
29Biosynthesis of amino acids_Homo sapiens_hsa012301.08755831
30Pentose phosphate pathway_Homo sapiens_hsa000301.07792847
31Folate biosynthesis_Homo sapiens_hsa007901.05885836
32Antigen processing and presentation_Homo sapiens_hsa046121.02720697
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.02603515
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00881778
35Selenocompound metabolism_Homo sapiens_hsa004500.97224927
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95659619
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94332023
38Viral carcinogenesis_Homo sapiens_hsa052030.93509441
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92789315
40Oocyte meiosis_Homo sapiens_hsa041140.89676965
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86754696
42Herpes simplex infection_Homo sapiens_hsa051680.84828392
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84329168
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.84294476
45Systemic lupus erythematosus_Homo sapiens_hsa053220.81151473
46Alzheimers disease_Homo sapiens_hsa050100.77827114
47Sulfur relay system_Homo sapiens_hsa041220.76640737
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76485500
49Fatty acid elongation_Homo sapiens_hsa000620.75600263
50HTLV-I infection_Homo sapiens_hsa051660.72769311
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70125603
52Thyroid cancer_Homo sapiens_hsa052160.68851509
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67826132
54Carbon metabolism_Homo sapiens_hsa012000.61959403
55MicroRNAs in cancer_Homo sapiens_hsa052060.61584854
56Legionellosis_Homo sapiens_hsa051340.60702840
57Small cell lung cancer_Homo sapiens_hsa052220.60107060
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58613494
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57467968
60Glutathione metabolism_Homo sapiens_hsa004800.54389739
61Protein export_Homo sapiens_hsa030600.54377661
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52439608
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52339467
64Steroid biosynthesis_Homo sapiens_hsa001000.49028204
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41713696
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41578424
67Apoptosis_Homo sapiens_hsa042100.41560030
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39139601
69Hippo signaling pathway_Homo sapiens_hsa043900.37523897
70Fructose and mannose metabolism_Homo sapiens_hsa000510.37435346
71TGF-beta signaling pathway_Homo sapiens_hsa043500.36964266
72Pancreatic cancer_Homo sapiens_hsa052120.35338859
73N-Glycan biosynthesis_Homo sapiens_hsa005100.35156850
74Primary immunodeficiency_Homo sapiens_hsa053400.34965288
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34722979
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34661418
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34202921
78Bladder cancer_Homo sapiens_hsa052190.33977901
79Shigellosis_Homo sapiens_hsa051310.32381330
80Hepatitis B_Homo sapiens_hsa051610.32001565
81Chronic myeloid leukemia_Homo sapiens_hsa052200.31436632
82Colorectal cancer_Homo sapiens_hsa052100.31296441
83Measles_Homo sapiens_hsa051620.30966150
84Arginine biosynthesis_Homo sapiens_hsa002200.30615079
85Propanoate metabolism_Homo sapiens_hsa006400.29714493
86HIF-1 signaling pathway_Homo sapiens_hsa040660.28603071
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.26398170
88Basal cell carcinoma_Homo sapiens_hsa052170.25571797
89Notch signaling pathway_Homo sapiens_hsa043300.25260480
90Galactose metabolism_Homo sapiens_hsa000520.25157290
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24243438
92Acute myeloid leukemia_Homo sapiens_hsa052210.22212737
93Viral myocarditis_Homo sapiens_hsa054160.22186970
94Cardiac muscle contraction_Homo sapiens_hsa042600.21733999
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.21687385
96mTOR signaling pathway_Homo sapiens_hsa041500.21398507
97Renin-angiotensin system_Homo sapiens_hsa046140.21366443
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20970363
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20223842
100Pathways in cancer_Homo sapiens_hsa052000.18527567
101Phenylalanine metabolism_Homo sapiens_hsa003600.18207207
102Huntingtons disease_Homo sapiens_hsa050160.17971761
103Prostate cancer_Homo sapiens_hsa052150.17800426
104Metabolic pathways_Homo sapiens_hsa011000.17284056
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17259070
106Influenza A_Homo sapiens_hsa051640.16712385
107Adherens junction_Homo sapiens_hsa045200.16701908
108Fatty acid metabolism_Homo sapiens_hsa012120.16581321
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13973320
110Regulation of autophagy_Homo sapiens_hsa041400.13070396
111Hematopoietic cell lineage_Homo sapiens_hsa046400.11083820
112Melanoma_Homo sapiens_hsa052180.10903542
113Wnt signaling pathway_Homo sapiens_hsa043100.10778378
114Arginine and proline metabolism_Homo sapiens_hsa003300.10303334
115Vitamin digestion and absorption_Homo sapiens_hsa049770.09846983
116Lysine degradation_Homo sapiens_hsa003100.09615269
117Non-small cell lung cancer_Homo sapiens_hsa052230.09440565
118Hedgehog signaling pathway_Homo sapiens_hsa043400.09340153
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08744915
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.07286452
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07096820
122Tyrosine metabolism_Homo sapiens_hsa003500.06895271

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