

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.16921299 |
| 2 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.73905191 |
| 3 | maturation of SSU-rRNA (GO:0030490) | 4.41531604 |
| 4 | proteasome assembly (GO:0043248) | 4.38263546 |
| 5 | chaperone-mediated protein transport (GO:0072321) | 4.24891309 |
| 6 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.06922757 |
| 7 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.98869349 |
| 8 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.98869349 |
| 9 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.98864168 |
| 10 | cytidine metabolic process (GO:0046087) | 3.74802755 |
| 11 | cytidine catabolic process (GO:0006216) | 3.74802755 |
| 12 | cytidine deamination (GO:0009972) | 3.74802755 |
| 13 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.73233673 |
| 14 | rRNA catabolic process (GO:0016075) | 3.72719469 |
| 15 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.68504538 |
| 16 | ATP synthesis coupled proton transport (GO:0015986) | 3.68504538 |
| 17 | peptidyl-histidine modification (GO:0018202) | 3.64708050 |
| 18 | positive regulation of protein homooligomerization (GO:0032464) | 3.63009755 |
| 19 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.54604288 |
| 20 | NADH dehydrogenase complex assembly (GO:0010257) | 3.53431712 |
| 21 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.53431712 |
| 22 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.53431712 |
| 23 | CENP-A containing nucleosome assembly (GO:0034080) | 3.49442911 |
| 24 | chromatin remodeling at centromere (GO:0031055) | 3.48944966 |
| 25 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.48858571 |
| 26 | IMP biosynthetic process (GO:0006188) | 3.47051845 |
| 27 | behavioral response to nicotine (GO:0035095) | 3.45669024 |
| 28 | DNA replication checkpoint (GO:0000076) | 3.41689509 |
| 29 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.38696467 |
| 30 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.37695560 |
| 31 | protein complex biogenesis (GO:0070271) | 3.34502932 |
| 32 | negative regulation of multicellular organism growth (GO:0040015) | 3.34168707 |
| 33 | negative regulation of T cell differentiation in thymus (GO:0033085) | 3.33370324 |
| 34 | nucleobase biosynthetic process (GO:0046112) | 3.33122786 |
| 35 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.29857168 |
| 36 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.28357648 |
| 37 | regulation of memory T cell differentiation (GO:0043380) | 3.26336788 |
| 38 | purine nucleobase biosynthetic process (GO:0009113) | 3.26301363 |
| 39 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.25141276 |
| 40 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.23612561 |
| 41 | striatum development (GO:0021756) | 3.23387509 |
| 42 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.22875850 |
| 43 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.22875850 |
| 44 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.22875850 |
| 45 | protein neddylation (GO:0045116) | 3.19350026 |
| 46 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.16778258 |
| 47 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.16778258 |
| 48 | piRNA metabolic process (GO:0034587) | 3.15708610 |
| 49 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.12836855 |
| 50 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.12836855 |
| 51 | positive regulation of defense response to virus by host (GO:0002230) | 3.12673282 |
| 52 | protein deneddylation (GO:0000338) | 3.12120631 |
| 53 | IMP metabolic process (GO:0046040) | 3.11313067 |
| 54 | DNA demethylation (GO:0080111) | 3.09949483 |
| 55 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.07954612 |
| 56 | cell proliferation in forebrain (GO:0021846) | 3.04990324 |
| 57 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.04947228 |
| 58 | termination of RNA polymerase III transcription (GO:0006386) | 3.03832202 |
| 59 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.03832202 |
| 60 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.02243888 |
| 61 | negative regulation of ligase activity (GO:0051352) | 3.02243888 |
| 62 | rRNA processing (GO:0006364) | 2.99971821 |
| 63 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.99644434 |
| 64 | protein K6-linked ubiquitination (GO:0085020) | 2.99046574 |
| 65 | platelet dense granule organization (GO:0060155) | 2.96882151 |
| 66 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.96643757 |
| 67 | rRNA metabolic process (GO:0016072) | 2.96415057 |
| 68 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.96226450 |
| 69 | negative regulation of telomere maintenance (GO:0032205) | 2.96097188 |
| 70 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.95988865 |
| 71 | nucleoside transmembrane transport (GO:1901642) | 2.93549889 |
| 72 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.93223763 |
| 73 | regulation of establishment of cell polarity (GO:2000114) | 2.89895869 |
| 74 | tRNA processing (GO:0008033) | 2.87340461 |
| 75 | purine nucleotide salvage (GO:0032261) | 2.86341720 |
| 76 | electron transport chain (GO:0022900) | 2.85583464 |
| 77 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.84866063 |
| 78 | synapsis (GO:0007129) | 2.82524065 |
| 79 | replication fork processing (GO:0031297) | 2.80876135 |
| 80 | respiratory electron transport chain (GO:0022904) | 2.80534747 |
| 81 | cellular response to interferon-beta (GO:0035458) | 2.78545088 |
| 82 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.76429089 |
| 83 | regulation of immune response to tumor cell (GO:0002837) | 2.73555625 |
| 84 | regulation of response to tumor cell (GO:0002834) | 2.73555625 |
| 85 | positive regulation of response to tumor cell (GO:0002836) | 2.73555625 |
| 86 | positive regulation of immune response to tumor cell (GO:0002839) | 2.73555625 |
| 87 | ribosomal small subunit biogenesis (GO:0042274) | 2.73220903 |
| 88 | DNA double-strand break processing (GO:0000729) | 2.72050428 |
| 89 | histone exchange (GO:0043486) | 2.70936741 |
| 90 | ribosomal small subunit assembly (GO:0000028) | 2.70180334 |
| 91 | regulation of posttranscriptional gene silencing (GO:0060147) | 2.68439453 |
| 92 | regulation of gene silencing by miRNA (GO:0060964) | 2.68439453 |
| 93 | regulation of gene silencing by RNA (GO:0060966) | 2.68439453 |
| 94 | negative regulation of astrocyte differentiation (GO:0048712) | 2.67017792 |
| 95 | spliceosomal complex assembly (GO:0000245) | 2.65265135 |
| 96 | serotonin receptor signaling pathway (GO:0007210) | 2.64925145 |
| 97 | pseudouridine synthesis (GO:0001522) | 2.64590303 |
| 98 | positive regulation of ligase activity (GO:0051351) | 2.64513098 |
| 99 | nucleotide transmembrane transport (GO:1901679) | 2.62881910 |
| 100 | RNA phosphodiester bond hydrolysis (GO:0090501) | 2.61956613 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VDR_22108803_ChIP-Seq_LS180_Human | 4.49694674 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.11746894 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.05014617 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.35201006 |
| 5 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.29526489 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.25222739 |
| 7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.10448759 |
| 8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.10031635 |
| 9 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.96988375 |
| 10 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.81479754 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.74060103 |
| 12 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.41735820 |
| 13 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.31866438 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.28694793 |
| 15 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.19624694 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.19222715 |
| 17 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.12118803 |
| 18 | FUS_26573619_Chip-Seq_HEK293_Human | 2.11156804 |
| 19 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.06162609 |
| 20 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.91967410 |
| 21 | EWS_26573619_Chip-Seq_HEK293_Human | 1.83668120 |
| 22 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.74824184 |
| 23 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.73772097 |
| 24 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.72291240 |
| 25 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.69227886 |
| 26 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.64346225 |
| 27 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.62044311 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.56025526 |
| 29 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.53944514 |
| 30 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.50782692 |
| 31 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.47153181 |
| 32 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.47153181 |
| 33 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.46663346 |
| 34 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.45007035 |
| 35 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.42547922 |
| 36 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.42226503 |
| 37 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.41548511 |
| 38 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.39644821 |
| 39 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.34022280 |
| 40 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.32540991 |
| 41 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.32151122 |
| 42 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.31378494 |
| 43 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.30098505 |
| 44 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.29789715 |
| 45 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.29537024 |
| 46 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.28964443 |
| 47 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.27639143 |
| 48 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.26816978 |
| 49 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.26135788 |
| 50 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.26028224 |
| 51 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.23265909 |
| 52 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.18956539 |
| 53 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.18306921 |
| 54 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.17143207 |
| 55 | NCOR_22424771_ChIP-Seq_293T_Human | 1.16709604 |
| 56 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.14938145 |
| 57 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.14204891 |
| 58 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.13093953 |
| 59 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.10879458 |
| 60 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.09229431 |
| 61 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.07915881 |
| 62 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.07510738 |
| 63 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.06567734 |
| 64 | P300_19829295_ChIP-Seq_ESCs_Human | 1.06277191 |
| 65 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.06165433 |
| 66 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.06066456 |
| 67 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.04666365 |
| 68 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.03661710 |
| 69 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.03491235 |
| 70 | AR_20517297_ChIP-Seq_VCAP_Human | 1.03359783 |
| 71 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.03118222 |
| 72 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.02543164 |
| 73 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.02275456 |
| 74 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.01180815 |
| 75 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.00889928 |
| 76 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.99515879 |
| 77 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.99515879 |
| 78 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.99241286 |
| 79 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.99123420 |
| 80 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.99087529 |
| 81 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.97605469 |
| 82 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.97106887 |
| 83 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.94595608 |
| 84 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.93997177 |
| 85 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.92212592 |
| 86 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.91825587 |
| 87 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.91750809 |
| 88 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.91718905 |
| 89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.88955923 |
| 90 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.88868418 |
| 91 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.88452465 |
| 92 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.88205991 |
| 93 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.88028404 |
| 94 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.87599645 |
| 95 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.86183194 |
| 96 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.86068007 |
| 97 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 0.85927070 |
| 98 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.85537503 |
| 99 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.85259649 |
| 100 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.84622016 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010030_abnormal_orbit_morphology | 3.71485624 |
| 2 | MP0003011_delayed_dark_adaptation | 3.15117178 |
| 3 | MP0004147_increased_porphyrin_level | 3.11755574 |
| 4 | MP0009379_abnormal_foot_pigmentation | 2.74201322 |
| 5 | MP0002163_abnormal_gland_morphology | 2.66711950 |
| 6 | MP0006072_abnormal_retinal_apoptosis | 2.47569622 |
| 7 | MP0003183_abnormal_peptide_metabolism | 2.30377319 |
| 8 | MP0003718_maternal_effect | 2.29321294 |
| 9 | MP0003646_muscle_fatigue | 2.26780708 |
| 10 | MP0004885_abnormal_endolymph | 2.23429331 |
| 11 | MP0001986_abnormal_taste_sensitivity | 2.12186269 |
| 12 | MP0001188_hyperpigmentation | 2.06353385 |
| 13 | MP0003136_yellow_coat_color | 2.00321153 |
| 14 | MP0009745_abnormal_behavioral_response | 1.99673950 |
| 15 | MP0002160_abnormal_reproductive_system | 1.89497598 |
| 16 | MP0002751_abnormal_autonomic_nervous | 1.87251051 |
| 17 | MP0001529_abnormal_vocalization | 1.86555278 |
| 18 | MP0001968_abnormal_touch/_nociception | 1.80696559 |
| 19 | MP0002736_abnormal_nociception_after | 1.77423482 |
| 20 | MP0005083_abnormal_biliary_tract | 1.72464874 |
| 21 | MP0010094_abnormal_chromosome_stability | 1.66576523 |
| 22 | MP0005379_endocrine/exocrine_gland_phen | 1.66084670 |
| 23 | MP0008007_abnormal_cellular_replicative | 1.63364667 |
| 24 | MP0002837_dystrophic_cardiac_calcinosis | 1.63232033 |
| 25 | MP0005551_abnormal_eye_electrophysiolog | 1.63044362 |
| 26 | MP0002095_abnormal_skin_pigmentation | 1.62385163 |
| 27 | MP0005671_abnormal_response_to | 1.62353431 |
| 28 | MP0000685_abnormal_immune_system | 1.62075667 |
| 29 | MP0002653_abnormal_ependyma_morphology | 1.59550088 |
| 30 | MP0008872_abnormal_physiological_respon | 1.58408561 |
| 31 | MP0005389_reproductive_system_phenotype | 1.56886607 |
| 32 | MP0005084_abnormal_gallbladder_morpholo | 1.55941003 |
| 33 | MP0005174_abnormal_tail_pigmentation | 1.52898432 |
| 34 | MP0003252_abnormal_bile_duct | 1.48288207 |
| 35 | MP0005253_abnormal_eye_physiology | 1.44832660 |
| 36 | MP0004142_abnormal_muscle_tone | 1.40979068 |
| 37 | MP0005075_abnormal_melanosome_morpholog | 1.37654467 |
| 38 | MP0002733_abnormal_thermal_nociception | 1.35555722 |
| 39 | MP0009046_muscle_twitch | 1.34227357 |
| 40 | MP0001502_abnormal_circadian_rhythm | 1.33999833 |
| 41 | MP0002876_abnormal_thyroid_physiology | 1.32081086 |
| 42 | MP0006292_abnormal_olfactory_placode | 1.29875459 |
| 43 | MP0008058_abnormal_DNA_repair | 1.28609292 |
| 44 | MP0003880_abnormal_central_pattern | 1.27756037 |
| 45 | MP0001485_abnormal_pinna_reflex | 1.26972116 |
| 46 | MP0005171_absent_coat_pigmentation | 1.26481846 |
| 47 | MP0002272_abnormal_nervous_system | 1.26220712 |
| 48 | MP0000427_abnormal_hair_cycle | 1.19057948 |
| 49 | MP0004215_abnormal_myocardial_fiber | 1.16821411 |
| 50 | MP0006036_abnormal_mitochondrial_physio | 1.13046816 |
| 51 | MP0003786_premature_aging | 1.12126705 |
| 52 | MP0001970_abnormal_pain_threshold | 1.12104789 |
| 53 | MP0001905_abnormal_dopamine_level | 1.12075251 |
| 54 | MP0003186_abnormal_redox_activity | 1.11541793 |
| 55 | MP0003806_abnormal_nucleotide_metabolis | 1.08964588 |
| 56 | MP0002735_abnormal_chemical_nociception | 1.08597677 |
| 57 | MP0002064_seizures | 1.08202068 |
| 58 | MP0002282_abnormal_trachea_morphology | 1.07287250 |
| 59 | MP0002210_abnormal_sex_determination | 1.07259657 |
| 60 | MP0002234_abnormal_pharynx_morphology | 1.04141786 |
| 61 | MP0001501_abnormal_sleep_pattern | 1.01862031 |
| 62 | MP0001919_abnormal_reproductive_system | 1.01674934 |
| 63 | MP0003693_abnormal_embryo_hatching | 1.00884272 |
| 64 | MP0008877_abnormal_DNA_methylation | 1.00767234 |
| 65 | MP0006035_abnormal_mitochondrial_morpho | 0.99329492 |
| 66 | MP0000372_irregular_coat_pigmentation | 0.97789865 |
| 67 | MP0002277_abnormal_respiratory_mucosa | 0.95996994 |
| 68 | MP0004742_abnormal_vestibular_system | 0.95947514 |
| 69 | MP0003763_abnormal_thymus_physiology | 0.94281700 |
| 70 | MP0001293_anophthalmia | 0.93558540 |
| 71 | MP0008789_abnormal_olfactory_epithelium | 0.92301941 |
| 72 | MP0001486_abnormal_startle_reflex | 0.89546759 |
| 73 | MP0005646_abnormal_pituitary_gland | 0.89538514 |
| 74 | MP0002938_white_spotting | 0.87752822 |
| 75 | MP0004133_heterotaxia | 0.87680128 |
| 76 | MP0005377_hearing/vestibular/ear_phenot | 0.86281333 |
| 77 | MP0003878_abnormal_ear_physiology | 0.86281333 |
| 78 | MP0002067_abnormal_sensory_capabilities | 0.85103871 |
| 79 | MP0009764_decreased_sensitivity_to | 0.84905075 |
| 80 | MP0008875_abnormal_xenobiotic_pharmacok | 0.84509254 |
| 81 | MP0002075_abnormal_coat/hair_pigmentati | 0.81931295 |
| 82 | MP0004957_abnormal_blastocyst_morpholog | 0.81806691 |
| 83 | MP0003077_abnormal_cell_cycle | 0.80511283 |
| 84 | MP0003635_abnormal_synaptic_transmissio | 0.80233327 |
| 85 | MP0002572_abnormal_emotion/affect_behav | 0.80176746 |
| 86 | MP0009785_altered_susceptibility_to | 0.79487415 |
| 87 | MP0001145_abnormal_male_reproductive | 0.79364869 |
| 88 | MP0000049_abnormal_middle_ear | 0.78958362 |
| 89 | MP0002638_abnormal_pupillary_reflex | 0.78735416 |
| 90 | MP0000371_diluted_coat_color | 0.78199435 |
| 91 | MP0001324_abnormal_eye_pigmentation | 0.77808798 |
| 92 | MP0005195_abnormal_posterior_eye | 0.77579804 |
| 93 | MP0001929_abnormal_gametogenesis | 0.77058965 |
| 94 | MP0001790_abnormal_immune_system | 0.77034683 |
| 95 | MP0005387_immune_system_phenotype | 0.77034683 |
| 96 | MP0000383_abnormal_hair_follicle | 0.76767427 |
| 97 | MP0005386_behavior/neurological_phenoty | 0.76681893 |
| 98 | MP0004924_abnormal_behavior | 0.76681893 |
| 99 | MP0001800_abnormal_humoral_immune | 0.75225857 |
| 100 | MP0002063_abnormal_learning/memory/cond | 0.74994523 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 6.90331657 |
| 2 | Abnormality of alanine metabolism (HP:0010916) | 6.90331657 |
| 3 | Hyperalaninemia (HP:0003348) | 6.90331657 |
| 4 | Genetic anticipation (HP:0003743) | 4.10864892 |
| 5 | Molar tooth sign on MRI (HP:0002419) | 3.49338488 |
| 6 | Abnormality of midbrain morphology (HP:0002418) | 3.49338488 |
| 7 | Progressive cerebellar ataxia (HP:0002073) | 3.23920333 |
| 8 | Acute necrotizing encephalopathy (HP:0006965) | 3.19466030 |
| 9 | Increased serum pyruvate (HP:0003542) | 2.97417244 |
| 10 | Microretrognathia (HP:0000308) | 2.96483896 |
| 11 | 3-Methylglutaconic aciduria (HP:0003535) | 2.96447937 |
| 12 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.92686103 |
| 13 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.91409216 |
| 14 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.84833979 |
| 15 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.84492298 |
| 16 | Hypoplasia of the uterus (HP:0000013) | 2.80947986 |
| 17 | Acute encephalopathy (HP:0006846) | 2.80190627 |
| 18 | Congenital stationary night blindness (HP:0007642) | 2.79984920 |
| 19 | Mitochondrial inheritance (HP:0001427) | 2.79205112 |
| 20 | Gaze-evoked nystagmus (HP:0000640) | 2.78355478 |
| 21 | Stomatitis (HP:0010280) | 2.75880324 |
| 22 | Increased CSF lactate (HP:0002490) | 2.70526666 |
| 23 | Type II lissencephaly (HP:0007260) | 2.69092309 |
| 24 | Nephronophthisis (HP:0000090) | 2.68108371 |
| 25 | Increased serum lactate (HP:0002151) | 2.66781015 |
| 26 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.55162569 |
| 27 | Pancreatic cysts (HP:0001737) | 2.47854546 |
| 28 | Retinal dysplasia (HP:0007973) | 2.46904980 |
| 29 | Hepatocellular necrosis (HP:0001404) | 2.44708801 |
| 30 | Birth length less than 3rd percentile (HP:0003561) | 2.44338367 |
| 31 | Flat capital femoral epiphysis (HP:0003370) | 2.43027852 |
| 32 | Progressive macrocephaly (HP:0004481) | 2.41945380 |
| 33 | Pendular nystagmus (HP:0012043) | 2.40613931 |
| 34 | Testicular atrophy (HP:0000029) | 2.36656527 |
| 35 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.36166859 |
| 36 | Abnormality of serum amino acid levels (HP:0003112) | 2.35900435 |
| 37 | Abnormality of the renal medulla (HP:0100957) | 2.35382434 |
| 38 | Abnormality of glycolysis (HP:0004366) | 2.34582381 |
| 39 | Optic disc pallor (HP:0000543) | 2.34241435 |
| 40 | Hepatic necrosis (HP:0002605) | 2.31744961 |
| 41 | Abolished electroretinogram (ERG) (HP:0000550) | 2.31737163 |
| 42 | Abnormality of the renal cortex (HP:0011035) | 2.31400244 |
| 43 | Constricted visual fields (HP:0001133) | 2.29313889 |
| 44 | Inability to walk (HP:0002540) | 2.27647908 |
| 45 | Reticulocytopenia (HP:0001896) | 2.27336563 |
| 46 | Attenuation of retinal blood vessels (HP:0007843) | 2.25065150 |
| 47 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.23796257 |
| 48 | Anophthalmia (HP:0000528) | 2.22860785 |
| 49 | Dyschromatopsia (HP:0007641) | 2.22668773 |
| 50 | IgG deficiency (HP:0004315) | 2.22132328 |
| 51 | IgM deficiency (HP:0002850) | 2.20458100 |
| 52 | Progressive inability to walk (HP:0002505) | 2.17434501 |
| 53 | Colon cancer (HP:0003003) | 2.17262312 |
| 54 | Abnormality of T cell physiology (HP:0011840) | 2.10965053 |
| 55 | Annular pancreas (HP:0001734) | 2.06472639 |
| 56 | Hypoproteinemia (HP:0003075) | 2.04112565 |
| 57 | Pancreatic fibrosis (HP:0100732) | 2.01917925 |
| 58 | True hermaphroditism (HP:0010459) | 1.97923607 |
| 59 | Congenital, generalized hypertrichosis (HP:0004540) | 1.95677513 |
| 60 | Oligodactyly (hands) (HP:0001180) | 1.95107490 |
| 61 | Absent/shortened dynein arms (HP:0200106) | 1.92167279 |
| 62 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.92167279 |
| 63 | Large for gestational age (HP:0001520) | 1.91610586 |
| 64 | Oculomotor apraxia (HP:0000657) | 1.91156214 |
| 65 | Abnormality of the labia minora (HP:0012880) | 1.90959439 |
| 66 | Lactic acidosis (HP:0003128) | 1.90395086 |
| 67 | Leukodystrophy (HP:0002415) | 1.84558338 |
| 68 | Chronic bronchitis (HP:0004469) | 1.82331829 |
| 69 | Abnormality of the prostate (HP:0008775) | 1.80753245 |
| 70 | Partial agenesis of the corpus callosum (HP:0001338) | 1.78660565 |
| 71 | Abnormality of B cell number (HP:0010975) | 1.78130752 |
| 72 | Patellar aplasia (HP:0006443) | 1.75996725 |
| 73 | Lissencephaly (HP:0001339) | 1.75918102 |
| 74 | Small intestinal stenosis (HP:0012848) | 1.75738600 |
| 75 | Duodenal stenosis (HP:0100867) | 1.75738600 |
| 76 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.75125695 |
| 77 | Prostate neoplasm (HP:0100787) | 1.74472445 |
| 78 | Severe global developmental delay (HP:0011344) | 1.73609916 |
| 79 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.73004815 |
| 80 | Progressive microcephaly (HP:0000253) | 1.72558951 |
| 81 | Cerebral edema (HP:0002181) | 1.71545809 |
| 82 | Focal motor seizures (HP:0011153) | 1.71421769 |
| 83 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.69940427 |
| 84 | Optic nerve coloboma (HP:0000588) | 1.69210274 |
| 85 | Abnormal number of erythroid precursors (HP:0012131) | 1.68983522 |
| 86 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.67522457 |
| 87 | Cleft eyelid (HP:0000625) | 1.66507323 |
| 88 | Abnormality of T cells (HP:0002843) | 1.64562622 |
| 89 | Type 2 muscle fiber atrophy (HP:0003554) | 1.61935723 |
| 90 | Methylmalonic acidemia (HP:0002912) | 1.61654245 |
| 91 | Tinnitus (HP:0000360) | 1.61577413 |
| 92 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.59501668 |
| 93 | Action tremor (HP:0002345) | 1.59471519 |
| 94 | Abnormality of macular pigmentation (HP:0008002) | 1.58982804 |
| 95 | Tubular atrophy (HP:0000092) | 1.58415844 |
| 96 | Congenital sensorineural hearing impairment (HP:0008527) | 1.57407460 |
| 97 | Small hand (HP:0200055) | 1.57327613 |
| 98 | Abnormal number of incisors (HP:0011064) | 1.56810594 |
| 99 | Bicornuate uterus (HP:0000813) | 1.56296593 |
| 100 | Macrocytic anemia (HP:0001972) | 1.55666245 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK19 | 3.71952982 |
| 2 | TAF1 | 2.99756659 |
| 3 | BUB1 | 2.97545395 |
| 4 | TXK | 2.89876528 |
| 5 | ZAK | 2.79983662 |
| 6 | OXSR1 | 2.62249812 |
| 7 | NTRK3 | 2.55968961 |
| 8 | TSSK6 | 2.48262784 |
| 9 | VRK2 | 2.33644542 |
| 10 | NEK1 | 2.33412030 |
| 11 | PINK1 | 2.19325324 |
| 12 | ADRBK2 | 2.09610337 |
| 13 | TLK1 | 2.06665926 |
| 14 | TESK2 | 1.98391995 |
| 15 | MAP3K12 | 1.93243468 |
| 16 | NUAK1 | 1.82347535 |
| 17 | BMPR1B | 1.80353415 |
| 18 | ACVR1B | 1.72827615 |
| 19 | FRK | 1.58468692 |
| 20 | GRK1 | 1.55689861 |
| 21 | VRK1 | 1.47303870 |
| 22 | CDC7 | 1.46978995 |
| 23 | TEC | 1.44008035 |
| 24 | WNK4 | 1.36000533 |
| 25 | DYRK2 | 1.35473524 |
| 26 | TRIM28 | 1.34271065 |
| 27 | ITK | 1.31507428 |
| 28 | PLK4 | 1.21230636 |
| 29 | IRAK1 | 1.19736468 |
| 30 | EIF2AK3 | 1.19171588 |
| 31 | PRKCG | 1.16181405 |
| 32 | TTK | 1.10932491 |
| 33 | CHEK2 | 1.09611255 |
| 34 | PDK2 | 1.07835449 |
| 35 | PLK3 | 1.06671259 |
| 36 | EIF2AK1 | 1.05830669 |
| 37 | NLK | 1.01791738 |
| 38 | PHKG1 | 1.00627903 |
| 39 | PHKG2 | 1.00627903 |
| 40 | MKNK2 | 0.99721381 |
| 41 | CSNK1G2 | 0.97562754 |
| 42 | KIT | 0.96988583 |
| 43 | MKNK1 | 0.93742432 |
| 44 | DAPK1 | 0.93273926 |
| 45 | SRPK1 | 0.92482369 |
| 46 | MAP3K11 | 0.89352490 |
| 47 | MAP4K1 | 0.88981684 |
| 48 | ATR | 0.85005608 |
| 49 | MAPK13 | 0.84213545 |
| 50 | MAP2K6 | 0.83814953 |
| 51 | ABL2 | 0.81652409 |
| 52 | PASK | 0.78893946 |
| 53 | BCKDK | 0.76438889 |
| 54 | IKBKE | 0.75078906 |
| 55 | ADRBK1 | 0.73998325 |
| 56 | PRKCE | 0.72829090 |
| 57 | CSNK1G1 | 0.72218622 |
| 58 | PIK3CA | 0.70787144 |
| 59 | WNK3 | 0.69938750 |
| 60 | RPS6KA5 | 0.69802954 |
| 61 | TGFBR1 | 0.68408917 |
| 62 | STK16 | 0.65108767 |
| 63 | CASK | 0.64459710 |
| 64 | AURKA | 0.64149106 |
| 65 | CSNK1G3 | 0.63340894 |
| 66 | TNIK | 0.63097115 |
| 67 | TAOK3 | 0.62413473 |
| 68 | ALK | 0.62283093 |
| 69 | IKBKB | 0.61607118 |
| 70 | LIMK1 | 0.60718362 |
| 71 | AURKB | 0.60489679 |
| 72 | DYRK1A | 0.59875050 |
| 73 | CAMKK2 | 0.59014729 |
| 74 | PLK1 | 0.58426957 |
| 75 | MST4 | 0.54970856 |
| 76 | NTRK2 | 0.51825718 |
| 77 | KDR | 0.51759992 |
| 78 | MAPKAPK3 | 0.50090600 |
| 79 | EIF2AK2 | 0.49161912 |
| 80 | CSNK1A1L | 0.48197319 |
| 81 | STK39 | 0.48165792 |
| 82 | BTK | 0.46475858 |
| 83 | TIE1 | 0.45965391 |
| 84 | RPS6KB2 | 0.45042569 |
| 85 | CSNK2A2 | 0.43788964 |
| 86 | CSNK2A1 | 0.42914675 |
| 87 | MAPK11 | 0.41911898 |
| 88 | INSRR | 0.41343978 |
| 89 | CAMK2A | 0.41098206 |
| 90 | MUSK | 0.40911087 |
| 91 | IRAK4 | 0.40864390 |
| 92 | TRPM7 | 0.39923209 |
| 93 | BRSK2 | 0.39877477 |
| 94 | MARK1 | 0.36531597 |
| 95 | BCR | 0.35278781 |
| 96 | DYRK3 | 0.35179361 |
| 97 | TNK2 | 0.34313766 |
| 98 | IGF1R | 0.33962423 |
| 99 | PRKG1 | 0.33884926 |
| 100 | PRKCA | 0.33642320 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.72542627 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.29252433 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.02140148 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.99484961 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.82525085 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 2.61429552 |
| 7 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.36812938 |
| 8 | RNA degradation_Homo sapiens_hsa03018 | 2.10381554 |
| 9 | Huntingtons disease_Homo sapiens_hsa05016 | 1.98132462 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 1.96944891 |
| 11 | Basal transcription factors_Homo sapiens_hsa03022 | 1.94014368 |
| 12 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.93634689 |
| 13 | Alzheimers disease_Homo sapiens_hsa05010 | 1.89315726 |
| 14 | Spliceosome_Homo sapiens_hsa03040 | 1.87647799 |
| 15 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.87524902 |
| 16 | Phototransduction_Homo sapiens_hsa04744 | 1.85057066 |
| 17 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.78676503 |
| 18 | Protein export_Homo sapiens_hsa03060 | 1.77724107 |
| 19 | Base excision repair_Homo sapiens_hsa03410 | 1.72385106 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.64392109 |
| 21 | DNA replication_Homo sapiens_hsa03030 | 1.58390083 |
| 22 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.51751879 |
| 23 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.49947194 |
| 24 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.48795797 |
| 25 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.47969759 |
| 26 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.47753922 |
| 27 | Purine metabolism_Homo sapiens_hsa00230 | 1.47703023 |
| 28 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.46782059 |
| 29 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.44987227 |
| 30 | RNA transport_Homo sapiens_hsa03013 | 1.40895054 |
| 31 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.40506458 |
| 32 | Mismatch repair_Homo sapiens_hsa03430 | 1.31502140 |
| 33 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.30202469 |
| 34 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.24867291 |
| 35 | Olfactory transduction_Homo sapiens_hsa04740 | 1.17963237 |
| 36 | Nicotine addiction_Homo sapiens_hsa05033 | 1.14637487 |
| 37 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.12363320 |
| 38 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.12128376 |
| 39 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.11844145 |
| 40 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.09788176 |
| 41 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.09117768 |
| 42 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.08957836 |
| 43 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.08207081 |
| 44 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.06376398 |
| 45 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.03913575 |
| 46 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.00288008 |
| 47 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.91040565 |
| 48 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.88505170 |
| 49 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.87151529 |
| 50 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.85192989 |
| 51 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.85038999 |
| 52 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.82306850 |
| 53 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.81426023 |
| 54 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.80820572 |
| 55 | Morphine addiction_Homo sapiens_hsa05032 | 0.78111591 |
| 56 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.75261108 |
| 57 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.71325606 |
| 58 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.70728014 |
| 59 | Taste transduction_Homo sapiens_hsa04742 | 0.69166472 |
| 60 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.68829324 |
| 61 | GABAergic synapse_Homo sapiens_hsa04727 | 0.67570896 |
| 62 | Retinol metabolism_Homo sapiens_hsa00830 | 0.67533485 |
| 63 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.63467877 |
| 64 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.62110033 |
| 65 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.61178688 |
| 66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.60900128 |
| 67 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.57924192 |
| 68 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.57497786 |
| 69 | Asthma_Homo sapiens_hsa05310 | 0.57321230 |
| 70 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.57253041 |
| 71 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.57020935 |
| 72 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.56643065 |
| 73 | Circadian rhythm_Homo sapiens_hsa04710 | 0.55630505 |
| 74 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.49326953 |
| 75 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.48862295 |
| 76 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.47491322 |
| 77 | Cell cycle_Homo sapiens_hsa04110 | 0.45919900 |
| 78 | Allograft rejection_Homo sapiens_hsa05330 | 0.43493224 |
| 79 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.42859362 |
| 80 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.42113448 |
| 81 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.42104644 |
| 82 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.41359104 |
| 83 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.40081141 |
| 84 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.38462938 |
| 85 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.37993763 |
| 86 | Peroxisome_Homo sapiens_hsa04146 | 0.36732579 |
| 87 | Salivary secretion_Homo sapiens_hsa04970 | 0.34865948 |
| 88 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.33780122 |
| 89 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.32804103 |
| 90 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.30959228 |
| 91 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.30478314 |
| 92 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.30330101 |
| 93 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.30287515 |
| 94 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.29927023 |
| 95 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.29661310 |
| 96 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.27806836 |
| 97 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.27767420 |
| 98 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.27489261 |
| 99 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.26572680 |
| 100 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.26157725 |

