PA2G4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.16921299
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.73905191
3maturation of SSU-rRNA (GO:0030490)4.41531604
4proteasome assembly (GO:0043248)4.38263546
5chaperone-mediated protein transport (GO:0072321)4.24891309
6exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.06922757
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.98869349
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.98869349
9nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.98864168
10cytidine metabolic process (GO:0046087)3.74802755
11cytidine catabolic process (GO:0006216)3.74802755
12cytidine deamination (GO:0009972)3.74802755
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.73233673
14rRNA catabolic process (GO:0016075)3.72719469
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.68504538
16ATP synthesis coupled proton transport (GO:0015986)3.68504538
17peptidyl-histidine modification (GO:0018202)3.64708050
18positive regulation of protein homooligomerization (GO:0032464)3.63009755
19negative regulation of DNA-dependent DNA replication (GO:2000104)3.54604288
20NADH dehydrogenase complex assembly (GO:0010257)3.53431712
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.53431712
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.53431712
23CENP-A containing nucleosome assembly (GO:0034080)3.49442911
24chromatin remodeling at centromere (GO:0031055)3.48944966
25RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.48858571
26IMP biosynthetic process (GO:0006188)3.47051845
27behavioral response to nicotine (GO:0035095)3.45669024
28DNA replication checkpoint (GO:0000076)3.41689509
29pyrimidine ribonucleoside catabolic process (GO:0046133)3.38696467
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37695560
31protein complex biogenesis (GO:0070271)3.34502932
32negative regulation of multicellular organism growth (GO:0040015)3.34168707
33negative regulation of T cell differentiation in thymus (GO:0033085)3.33370324
34nucleobase biosynthetic process (GO:0046112)3.33122786
35DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.29857168
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.28357648
37regulation of memory T cell differentiation (GO:0043380)3.26336788
38purine nucleobase biosynthetic process (GO:0009113)3.26301363
39mitochondrial respiratory chain complex assembly (GO:0033108)3.25141276
40regulation of cellular amino acid metabolic process (GO:0006521)3.23612561
41striatum development (GO:0021756)3.23387509
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22875850
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22875850
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22875850
45protein neddylation (GO:0045116)3.19350026
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16778258
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16778258
48piRNA metabolic process (GO:0034587)3.15708610
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.12836855
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12836855
51positive regulation of defense response to virus by host (GO:0002230)3.12673282
52protein deneddylation (GO:0000338)3.12120631
53IMP metabolic process (GO:0046040)3.11313067
54DNA demethylation (GO:0080111)3.09949483
55signal transduction involved in cell cycle checkpoint (GO:0072395)3.07954612
56cell proliferation in forebrain (GO:0021846)3.04990324
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04947228
58termination of RNA polymerase III transcription (GO:0006386)3.03832202
59transcription elongation from RNA polymerase III promoter (GO:0006385)3.03832202
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02243888
61negative regulation of ligase activity (GO:0051352)3.02243888
62rRNA processing (GO:0006364)2.99971821
63regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99644434
64protein K6-linked ubiquitination (GO:0085020)2.99046574
65platelet dense granule organization (GO:0060155)2.96882151
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.96643757
67rRNA metabolic process (GO:0016072)2.96415057
68deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96226450
69negative regulation of telomere maintenance (GO:0032205)2.96097188
70L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95988865
71nucleoside transmembrane transport (GO:1901642)2.93549889
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93223763
73regulation of establishment of cell polarity (GO:2000114)2.89895869
74tRNA processing (GO:0008033)2.87340461
75purine nucleotide salvage (GO:0032261)2.86341720
76electron transport chain (GO:0022900)2.85583464
77water-soluble vitamin biosynthetic process (GO:0042364)2.84866063
78synapsis (GO:0007129)2.82524065
79replication fork processing (GO:0031297)2.80876135
80respiratory electron transport chain (GO:0022904)2.80534747
81cellular response to interferon-beta (GO:0035458)2.78545088
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.76429089
83regulation of immune response to tumor cell (GO:0002837)2.73555625
84regulation of response to tumor cell (GO:0002834)2.73555625
85positive regulation of response to tumor cell (GO:0002836)2.73555625
86positive regulation of immune response to tumor cell (GO:0002839)2.73555625
87ribosomal small subunit biogenesis (GO:0042274)2.73220903
88DNA double-strand break processing (GO:0000729)2.72050428
89histone exchange (GO:0043486)2.70936741
90ribosomal small subunit assembly (GO:0000028)2.70180334
91regulation of posttranscriptional gene silencing (GO:0060147)2.68439453
92regulation of gene silencing by miRNA (GO:0060964)2.68439453
93regulation of gene silencing by RNA (GO:0060966)2.68439453
94negative regulation of astrocyte differentiation (GO:0048712)2.67017792
95spliceosomal complex assembly (GO:0000245)2.65265135
96serotonin receptor signaling pathway (GO:0007210)2.64925145
97pseudouridine synthesis (GO:0001522)2.64590303
98positive regulation of ligase activity (GO:0051351)2.64513098
99nucleotide transmembrane transport (GO:1901679)2.62881910
100RNA phosphodiester bond hydrolysis (GO:0090501)2.61956613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.49694674
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.11746894
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05014617
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.35201006
5E2F7_22180533_ChIP-Seq_HELA_Human3.29526489
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.25222739
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.10448759
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10031635
9ZNF274_21170338_ChIP-Seq_K562_Hela2.96988375
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81479754
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.74060103
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.41735820
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31866438
14VDR_23849224_ChIP-Seq_CD4+_Human2.28694793
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19624694
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19222715
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.12118803
18FUS_26573619_Chip-Seq_HEK293_Human2.11156804
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.06162609
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91967410
21EWS_26573619_Chip-Seq_HEK293_Human1.83668120
22ELK1_19687146_ChIP-ChIP_HELA_Human1.74824184
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73772097
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72291240
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69227886
26EZH2_22144423_ChIP-Seq_EOC_Human1.64346225
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62044311
28FOXP3_21729870_ChIP-Seq_TREG_Human1.56025526
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53944514
30ER_23166858_ChIP-Seq_MCF-7_Human1.50782692
31FOXA1_25329375_ChIP-Seq_VCAP_Human1.47153181
32FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47153181
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.46663346
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45007035
35TAF15_26573619_Chip-Seq_HEK293_Human1.42547922
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42226503
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41548511
38MYC_18940864_ChIP-ChIP_HL60_Human1.39644821
39GBX2_23144817_ChIP-Seq_PC3_Human1.34022280
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32540991
41GABP_19822575_ChIP-Seq_HepG2_Human1.32151122
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31378494
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30098505
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29789715
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29537024
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28964443
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27639143
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26816978
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26135788
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26028224
51TTF2_22483619_ChIP-Seq_HELA_Human1.23265909
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18956539
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18306921
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17143207
55NCOR_22424771_ChIP-Seq_293T_Human1.16709604
56TP53_22573176_ChIP-Seq_HFKS_Human1.14938145
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14204891
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13093953
59IRF1_19129219_ChIP-ChIP_H3396_Human1.10879458
60IGF1R_20145208_ChIP-Seq_DFB_Human1.09229431
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07915881
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07510738
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.06567734
64P300_19829295_ChIP-Seq_ESCs_Human1.06277191
65STAT3_18555785_Chip-Seq_ESCs_Mouse1.06165433
66TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06066456
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.04666365
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03661710
69NANOG_20526341_ChIP-Seq_ESCs_Human1.03491235
70AR_20517297_ChIP-Seq_VCAP_Human1.03359783
71ERG_20517297_ChIP-Seq_VCAP_Human1.03118222
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02543164
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02275456
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01180815
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.00889928
76SOX2_19829295_ChIP-Seq_ESCs_Human0.99515879
77NANOG_19829295_ChIP-Seq_ESCs_Human0.99515879
78TCF4_22108803_ChIP-Seq_LS180_Human0.99241286
79POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99123420
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99087529
81E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97605469
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97106887
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94595608
84FOXH1_21741376_ChIP-Seq_EPCs_Human0.93997177
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92212592
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91825587
87SMAD4_21741376_ChIP-Seq_EPCs_Human0.91750809
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91718905
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88955923
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88868418
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88452465
92TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88205991
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.88028404
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87599645
95HOXB7_26014856_ChIP-Seq_BT474_Human0.86183194
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86068007
97NMYC_18555785_Chip-Seq_ESCs_Mouse0.85927070
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.85537503
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85259649
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84622016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.71485624
2MP0003011_delayed_dark_adaptation3.15117178
3MP0004147_increased_porphyrin_level3.11755574
4MP0009379_abnormal_foot_pigmentation2.74201322
5MP0002163_abnormal_gland_morphology2.66711950
6MP0006072_abnormal_retinal_apoptosis2.47569622
7MP0003183_abnormal_peptide_metabolism2.30377319
8MP0003718_maternal_effect2.29321294
9MP0003646_muscle_fatigue2.26780708
10MP0004885_abnormal_endolymph2.23429331
11MP0001986_abnormal_taste_sensitivity2.12186269
12MP0001188_hyperpigmentation2.06353385
13MP0003136_yellow_coat_color2.00321153
14MP0009745_abnormal_behavioral_response1.99673950
15MP0002160_abnormal_reproductive_system1.89497598
16MP0002751_abnormal_autonomic_nervous1.87251051
17MP0001529_abnormal_vocalization1.86555278
18MP0001968_abnormal_touch/_nociception1.80696559
19MP0002736_abnormal_nociception_after1.77423482
20MP0005083_abnormal_biliary_tract1.72464874
21MP0010094_abnormal_chromosome_stability1.66576523
22MP0005379_endocrine/exocrine_gland_phen1.66084670
23MP0008007_abnormal_cellular_replicative1.63364667
24MP0002837_dystrophic_cardiac_calcinosis1.63232033
25MP0005551_abnormal_eye_electrophysiolog1.63044362
26MP0002095_abnormal_skin_pigmentation1.62385163
27MP0005671_abnormal_response_to1.62353431
28MP0000685_abnormal_immune_system1.62075667
29MP0002653_abnormal_ependyma_morphology1.59550088
30MP0008872_abnormal_physiological_respon1.58408561
31MP0005389_reproductive_system_phenotype1.56886607
32MP0005084_abnormal_gallbladder_morpholo1.55941003
33MP0005174_abnormal_tail_pigmentation1.52898432
34MP0003252_abnormal_bile_duct1.48288207
35MP0005253_abnormal_eye_physiology1.44832660
36MP0004142_abnormal_muscle_tone1.40979068
37MP0005075_abnormal_melanosome_morpholog1.37654467
38MP0002733_abnormal_thermal_nociception1.35555722
39MP0009046_muscle_twitch1.34227357
40MP0001502_abnormal_circadian_rhythm1.33999833
41MP0002876_abnormal_thyroid_physiology1.32081086
42MP0006292_abnormal_olfactory_placode1.29875459
43MP0008058_abnormal_DNA_repair1.28609292
44MP0003880_abnormal_central_pattern1.27756037
45MP0001485_abnormal_pinna_reflex1.26972116
46MP0005171_absent_coat_pigmentation1.26481846
47MP0002272_abnormal_nervous_system1.26220712
48MP0000427_abnormal_hair_cycle1.19057948
49MP0004215_abnormal_myocardial_fiber1.16821411
50MP0006036_abnormal_mitochondrial_physio1.13046816
51MP0003786_premature_aging1.12126705
52MP0001970_abnormal_pain_threshold1.12104789
53MP0001905_abnormal_dopamine_level1.12075251
54MP0003186_abnormal_redox_activity1.11541793
55MP0003806_abnormal_nucleotide_metabolis1.08964588
56MP0002735_abnormal_chemical_nociception1.08597677
57MP0002064_seizures1.08202068
58MP0002282_abnormal_trachea_morphology1.07287250
59MP0002210_abnormal_sex_determination1.07259657
60MP0002234_abnormal_pharynx_morphology1.04141786
61MP0001501_abnormal_sleep_pattern1.01862031
62MP0001919_abnormal_reproductive_system1.01674934
63MP0003693_abnormal_embryo_hatching1.00884272
64MP0008877_abnormal_DNA_methylation1.00767234
65MP0006035_abnormal_mitochondrial_morpho0.99329492
66MP0000372_irregular_coat_pigmentation0.97789865
67MP0002277_abnormal_respiratory_mucosa0.95996994
68MP0004742_abnormal_vestibular_system0.95947514
69MP0003763_abnormal_thymus_physiology0.94281700
70MP0001293_anophthalmia0.93558540
71MP0008789_abnormal_olfactory_epithelium0.92301941
72MP0001486_abnormal_startle_reflex0.89546759
73MP0005646_abnormal_pituitary_gland0.89538514
74MP0002938_white_spotting0.87752822
75MP0004133_heterotaxia0.87680128
76MP0005377_hearing/vestibular/ear_phenot0.86281333
77MP0003878_abnormal_ear_physiology0.86281333
78MP0002067_abnormal_sensory_capabilities0.85103871
79MP0009764_decreased_sensitivity_to0.84905075
80MP0008875_abnormal_xenobiotic_pharmacok0.84509254
81MP0002075_abnormal_coat/hair_pigmentati0.81931295
82MP0004957_abnormal_blastocyst_morpholog0.81806691
83MP0003077_abnormal_cell_cycle0.80511283
84MP0003635_abnormal_synaptic_transmissio0.80233327
85MP0002572_abnormal_emotion/affect_behav0.80176746
86MP0009785_altered_susceptibility_to0.79487415
87MP0001145_abnormal_male_reproductive0.79364869
88MP0000049_abnormal_middle_ear0.78958362
89MP0002638_abnormal_pupillary_reflex0.78735416
90MP0000371_diluted_coat_color0.78199435
91MP0001324_abnormal_eye_pigmentation0.77808798
92MP0005195_abnormal_posterior_eye0.77579804
93MP0001929_abnormal_gametogenesis0.77058965
94MP0001790_abnormal_immune_system0.77034683
95MP0005387_immune_system_phenotype0.77034683
96MP0000383_abnormal_hair_follicle0.76767427
97MP0005386_behavior/neurological_phenoty0.76681893
98MP0004924_abnormal_behavior0.76681893
99MP0001800_abnormal_humoral_immune0.75225857
100MP0002063_abnormal_learning/memory/cond0.74994523

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.90331657
2Abnormality of alanine metabolism (HP:0010916)6.90331657
3Hyperalaninemia (HP:0003348)6.90331657
4Genetic anticipation (HP:0003743)4.10864892
5Molar tooth sign on MRI (HP:0002419)3.49338488
6Abnormality of midbrain morphology (HP:0002418)3.49338488
7Progressive cerebellar ataxia (HP:0002073)3.23920333
8Acute necrotizing encephalopathy (HP:0006965)3.19466030
9Increased serum pyruvate (HP:0003542)2.97417244
10Microretrognathia (HP:0000308)2.96483896
113-Methylglutaconic aciduria (HP:0003535)2.96447937
12Decreased electroretinogram (ERG) amplitude (HP:0000654)2.92686103
13Aplasia/hypoplasia of the uterus (HP:0008684)2.91409216
14Absent rod-and cone-mediated responses on ERG (HP:0007688)2.84833979
15Abnormal mitochondria in muscle tissue (HP:0008316)2.84492298
16Hypoplasia of the uterus (HP:0000013)2.80947986
17Acute encephalopathy (HP:0006846)2.80190627
18Congenital stationary night blindness (HP:0007642)2.79984920
19Mitochondrial inheritance (HP:0001427)2.79205112
20Gaze-evoked nystagmus (HP:0000640)2.78355478
21Stomatitis (HP:0010280)2.75880324
22Increased CSF lactate (HP:0002490)2.70526666
23Type II lissencephaly (HP:0007260)2.69092309
24Nephronophthisis (HP:0000090)2.68108371
25Increased serum lactate (HP:0002151)2.66781015
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.55162569
27Pancreatic cysts (HP:0001737)2.47854546
28Retinal dysplasia (HP:0007973)2.46904980
29Hepatocellular necrosis (HP:0001404)2.44708801
30Birth length less than 3rd percentile (HP:0003561)2.44338367
31Flat capital femoral epiphysis (HP:0003370)2.43027852
32Progressive macrocephaly (HP:0004481)2.41945380
33Pendular nystagmus (HP:0012043)2.40613931
34Testicular atrophy (HP:0000029)2.36656527
35Elevated erythrocyte sedimentation rate (HP:0003565)2.36166859
36Abnormality of serum amino acid levels (HP:0003112)2.35900435
37Abnormality of the renal medulla (HP:0100957)2.35382434
38Abnormality of glycolysis (HP:0004366)2.34582381
39Optic disc pallor (HP:0000543)2.34241435
40Hepatic necrosis (HP:0002605)2.31744961
41Abolished electroretinogram (ERG) (HP:0000550)2.31737163
42Abnormality of the renal cortex (HP:0011035)2.31400244
43Constricted visual fields (HP:0001133)2.29313889
44Inability to walk (HP:0002540)2.27647908
45Reticulocytopenia (HP:0001896)2.27336563
46Attenuation of retinal blood vessels (HP:0007843)2.25065150
47Abnormal rod and cone electroretinograms (HP:0008323)2.23796257
48Anophthalmia (HP:0000528)2.22860785
49Dyschromatopsia (HP:0007641)2.22668773
50IgG deficiency (HP:0004315)2.22132328
51IgM deficiency (HP:0002850)2.20458100
52Progressive inability to walk (HP:0002505)2.17434501
53Colon cancer (HP:0003003)2.17262312
54Abnormality of T cell physiology (HP:0011840)2.10965053
55Annular pancreas (HP:0001734)2.06472639
56Hypoproteinemia (HP:0003075)2.04112565
57Pancreatic fibrosis (HP:0100732)2.01917925
58True hermaphroditism (HP:0010459)1.97923607
59Congenital, generalized hypertrichosis (HP:0004540)1.95677513
60Oligodactyly (hands) (HP:0001180)1.95107490
61Absent/shortened dynein arms (HP:0200106)1.92167279
62Dynein arm defect of respiratory motile cilia (HP:0012255)1.92167279
63Large for gestational age (HP:0001520)1.91610586
64Oculomotor apraxia (HP:0000657)1.91156214
65Abnormality of the labia minora (HP:0012880)1.90959439
66Lactic acidosis (HP:0003128)1.90395086
67Leukodystrophy (HP:0002415)1.84558338
68Chronic bronchitis (HP:0004469)1.82331829
69Abnormality of the prostate (HP:0008775)1.80753245
70Partial agenesis of the corpus callosum (HP:0001338)1.78660565
71Abnormality of B cell number (HP:0010975)1.78130752
72Patellar aplasia (HP:0006443)1.75996725
73Lissencephaly (HP:0001339)1.75918102
74Small intestinal stenosis (HP:0012848)1.75738600
75Duodenal stenosis (HP:0100867)1.75738600
76Abnormality of cells of the erythroid lineage (HP:0012130)1.75125695
77Prostate neoplasm (HP:0100787)1.74472445
78Severe global developmental delay (HP:0011344)1.73609916
79Aplasia/Hypoplasia of the patella (HP:0006498)1.73004815
80Progressive microcephaly (HP:0000253)1.72558951
81Cerebral edema (HP:0002181)1.71545809
82Focal motor seizures (HP:0011153)1.71421769
83Urinary bladder sphincter dysfunction (HP:0002839)1.69940427
84Optic nerve coloboma (HP:0000588)1.69210274
85Abnormal number of erythroid precursors (HP:0012131)1.68983522
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.67522457
87Cleft eyelid (HP:0000625)1.66507323
88Abnormality of T cells (HP:0002843)1.64562622
89Type 2 muscle fiber atrophy (HP:0003554)1.61935723
90Methylmalonic acidemia (HP:0002912)1.61654245
91Tinnitus (HP:0000360)1.61577413
92Abnormal respiratory motile cilium physiology (HP:0012261)1.59501668
93Action tremor (HP:0002345)1.59471519
94Abnormality of macular pigmentation (HP:0008002)1.58982804
95Tubular atrophy (HP:0000092)1.58415844
96Congenital sensorineural hearing impairment (HP:0008527)1.57407460
97Small hand (HP:0200055)1.57327613
98Abnormal number of incisors (HP:0011064)1.56810594
99Bicornuate uterus (HP:0000813)1.56296593
100Macrocytic anemia (HP:0001972)1.55666245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK193.71952982
2TAF12.99756659
3BUB12.97545395
4TXK2.89876528
5ZAK2.79983662
6OXSR12.62249812
7NTRK32.55968961
8TSSK62.48262784
9VRK22.33644542
10NEK12.33412030
11PINK12.19325324
12ADRBK22.09610337
13TLK12.06665926
14TESK21.98391995
15MAP3K121.93243468
16NUAK11.82347535
17BMPR1B1.80353415
18ACVR1B1.72827615
19FRK1.58468692
20GRK11.55689861
21VRK11.47303870
22CDC71.46978995
23TEC1.44008035
24WNK41.36000533
25DYRK21.35473524
26TRIM281.34271065
27ITK1.31507428
28PLK41.21230636
29IRAK11.19736468
30EIF2AK31.19171588
31PRKCG1.16181405
32TTK1.10932491
33CHEK21.09611255
34PDK21.07835449
35PLK31.06671259
36EIF2AK11.05830669
37NLK1.01791738
38PHKG11.00627903
39PHKG21.00627903
40MKNK20.99721381
41CSNK1G20.97562754
42KIT0.96988583
43MKNK10.93742432
44DAPK10.93273926
45SRPK10.92482369
46MAP3K110.89352490
47MAP4K10.88981684
48ATR0.85005608
49MAPK130.84213545
50MAP2K60.83814953
51ABL20.81652409
52PASK0.78893946
53BCKDK0.76438889
54IKBKE0.75078906
55ADRBK10.73998325
56PRKCE0.72829090
57CSNK1G10.72218622
58PIK3CA0.70787144
59WNK30.69938750
60RPS6KA50.69802954
61TGFBR10.68408917
62STK160.65108767
63CASK0.64459710
64AURKA0.64149106
65CSNK1G30.63340894
66TNIK0.63097115
67TAOK30.62413473
68ALK0.62283093
69IKBKB0.61607118
70LIMK10.60718362
71AURKB0.60489679
72DYRK1A0.59875050
73CAMKK20.59014729
74PLK10.58426957
75MST40.54970856
76NTRK20.51825718
77KDR0.51759992
78MAPKAPK30.50090600
79EIF2AK20.49161912
80CSNK1A1L0.48197319
81STK390.48165792
82BTK0.46475858
83TIE10.45965391
84RPS6KB20.45042569
85CSNK2A20.43788964
86CSNK2A10.42914675
87MAPK110.41911898
88INSRR0.41343978
89CAMK2A0.41098206
90MUSK0.40911087
91IRAK40.40864390
92TRPM70.39923209
93BRSK20.39877477
94MARK10.36531597
95BCR0.35278781
96DYRK30.35179361
97TNK20.34313766
98IGF1R0.33962423
99PRKG10.33884926
100PRKCA0.33642320

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.72542627
2Oxidative phosphorylation_Homo sapiens_hsa001903.29252433
3Ribosome_Homo sapiens_hsa030103.02140148
4Parkinsons disease_Homo sapiens_hsa050122.99484961
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82525085
6RNA polymerase_Homo sapiens_hsa030202.61429552
7Primary immunodeficiency_Homo sapiens_hsa053402.36812938
8RNA degradation_Homo sapiens_hsa030182.10381554
9Huntingtons disease_Homo sapiens_hsa050161.98132462
10Homologous recombination_Homo sapiens_hsa034401.96944891
11Basal transcription factors_Homo sapiens_hsa030221.94014368
12One carbon pool by folate_Homo sapiens_hsa006701.93634689
13Alzheimers disease_Homo sapiens_hsa050101.89315726
14Spliceosome_Homo sapiens_hsa030401.87647799
15Nitrogen metabolism_Homo sapiens_hsa009101.87524902
16Phototransduction_Homo sapiens_hsa047441.85057066
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78676503
18Protein export_Homo sapiens_hsa030601.77724107
19Base excision repair_Homo sapiens_hsa034101.72385106
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64392109
21DNA replication_Homo sapiens_hsa030301.58390083
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51751879
23Cardiac muscle contraction_Homo sapiens_hsa042601.49947194
24Non-homologous end-joining_Homo sapiens_hsa034501.48795797
25Antigen processing and presentation_Homo sapiens_hsa046121.47969759
26Pyrimidine metabolism_Homo sapiens_hsa002401.47753922
27Purine metabolism_Homo sapiens_hsa002301.47703023
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46782059
29Fanconi anemia pathway_Homo sapiens_hsa034601.44987227
30RNA transport_Homo sapiens_hsa030131.40895054
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40506458
32Mismatch repair_Homo sapiens_hsa034301.31502140
33Nucleotide excision repair_Homo sapiens_hsa034201.30202469
34Linoleic acid metabolism_Homo sapiens_hsa005911.24867291
35Olfactory transduction_Homo sapiens_hsa047401.17963237
36Nicotine addiction_Homo sapiens_hsa050331.14637487
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12363320
38Propanoate metabolism_Homo sapiens_hsa006401.12128376
39Caffeine metabolism_Homo sapiens_hsa002321.11844145
40Graft-versus-host disease_Homo sapiens_hsa053321.09788176
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.09117768
42Pyruvate metabolism_Homo sapiens_hsa006201.08957836
43Butanoate metabolism_Homo sapiens_hsa006501.08207081
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06376398
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.03913575
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00288008
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.91040565
48Ether lipid metabolism_Homo sapiens_hsa005650.88505170
49Regulation of autophagy_Homo sapiens_hsa041400.87151529
50Tryptophan metabolism_Homo sapiens_hsa003800.85192989
51Selenocompound metabolism_Homo sapiens_hsa004500.85038999
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82306850
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81426023
54Sulfur metabolism_Homo sapiens_hsa009200.80820572
55Morphine addiction_Homo sapiens_hsa050320.78111591
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75261108
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71325606
58Chemical carcinogenesis_Homo sapiens_hsa052040.70728014
59Taste transduction_Homo sapiens_hsa047420.69166472
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68829324
61GABAergic synapse_Homo sapiens_hsa047270.67570896
62Retinol metabolism_Homo sapiens_hsa008300.67533485
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.63467877
64p53 signaling pathway_Homo sapiens_hsa041150.62110033
65Folate biosynthesis_Homo sapiens_hsa007900.61178688
66Metabolic pathways_Homo sapiens_hsa011000.60900128
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57924192
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57497786
69Asthma_Homo sapiens_hsa053100.57321230
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57253041
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57020935
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.56643065
73Circadian rhythm_Homo sapiens_hsa047100.55630505
74Autoimmune thyroid disease_Homo sapiens_hsa053200.49326953
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48862295
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47491322
77Cell cycle_Homo sapiens_hsa041100.45919900
78Allograft rejection_Homo sapiens_hsa053300.43493224
79Hematopoietic cell lineage_Homo sapiens_hsa046400.42859362
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42113448
81Fatty acid biosynthesis_Homo sapiens_hsa000610.42104644
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.41359104
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.40081141
84Type I diabetes mellitus_Homo sapiens_hsa049400.38462938
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37993763
86Peroxisome_Homo sapiens_hsa041460.36732579
87Salivary secretion_Homo sapiens_hsa049700.34865948
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33780122
89Ovarian steroidogenesis_Homo sapiens_hsa049130.32804103
90Serotonergic synapse_Homo sapiens_hsa047260.30959228
91Calcium signaling pathway_Homo sapiens_hsa040200.30478314
92Collecting duct acid secretion_Homo sapiens_hsa049660.30330101
93Steroid biosynthesis_Homo sapiens_hsa001000.30287515
94mRNA surveillance pathway_Homo sapiens_hsa030150.29927023
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29661310
96beta-Alanine metabolism_Homo sapiens_hsa004100.27806836
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27767420
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27489261
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26572680
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26157725

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