PA2G4P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.03848268
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.10511501
3ATP synthesis coupled proton transport (GO:0015986)5.10511501
4cytidine metabolic process (GO:0046087)4.97090218
5cytidine catabolic process (GO:0006216)4.97090218
6cytidine deamination (GO:0009972)4.97090218
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.87534794
8ribosomal small subunit assembly (GO:0000028)4.84934796
9chaperone-mediated protein transport (GO:0072321)4.77441644
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.32161882
11behavioral response to nicotine (GO:0035095)4.29488876
12pyrimidine ribonucleoside catabolic process (GO:0046133)4.23832366
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.08756342
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.04232663
15NADH dehydrogenase complex assembly (GO:0010257)4.04232663
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.04232663
17protein complex biogenesis (GO:0070271)4.00784300
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.94197802
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.94197802
20regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.77719460
21ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.76355178
22protein neddylation (GO:0045116)3.75997542
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74885534
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72686542
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71489789
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.70812932
27atrial cardiac muscle cell action potential (GO:0086014)3.67915996
28proteasome assembly (GO:0043248)3.67218780
29replication fork processing (GO:0031297)3.64656022
30mitochondrial respiratory chain complex assembly (GO:0033108)3.56869356
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.54060711
32termination of RNA polymerase III transcription (GO:0006386)3.54060711
33endoderm formation (GO:0001706)3.48324714
34respiratory electron transport chain (GO:0022904)3.40499614
35platelet dense granule organization (GO:0060155)3.37740605
36electron transport chain (GO:0022900)3.36126981
37protein-cofactor linkage (GO:0018065)3.31847897
38maturation of SSU-rRNA (GO:0030490)3.31662865
39cAMP biosynthetic process (GO:0006171)3.30535469
40rRNA catabolic process (GO:0016075)3.16180356
41pseudouridine synthesis (GO:0001522)3.14040216
42protein deneddylation (GO:0000338)3.12525784
43base-excision repair, AP site formation (GO:0006285)3.07377224
44cullin deneddylation (GO:0010388)3.03190931
45resolution of meiotic recombination intermediates (GO:0000712)3.02605304
46tRNA processing (GO:0008033)3.00127348
47chromatin remodeling at centromere (GO:0031055)2.93805679
48respiratory chain complex IV assembly (GO:0008535)2.90987729
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85231195
50GTP biosynthetic process (GO:0006183)2.84717886
51ncRNA 3-end processing (GO:0043628)2.84602411
52sequestering of actin monomers (GO:0042989)2.83165414
53tachykinin receptor signaling pathway (GO:0007217)2.83108609
54regulation of mitotic spindle checkpoint (GO:1903504)2.82781108
55regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82781108
56interferon-gamma production (GO:0032609)2.80630190
57rRNA modification (GO:0000154)2.78366962
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.77768663
59anterograde synaptic vesicle transport (GO:0048490)2.76888944
60rRNA metabolic process (GO:0016072)2.75941614
61hydrogen ion transmembrane transport (GO:1902600)2.75739893
62CENP-A containing nucleosome assembly (GO:0034080)2.75604395
63ATP biosynthetic process (GO:0006754)2.75574171
64maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75442248
65protein peptidyl-prolyl isomerization (GO:0000413)2.74873168
66purine nucleoside triphosphate biosynthetic process (GO:0009145)2.74636130
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73983654
68ribosomal large subunit biogenesis (GO:0042273)2.73430804
69rRNA processing (GO:0006364)2.71387598
70cellular component biogenesis (GO:0044085)2.67188043
71regulation of cellular amino acid metabolic process (GO:0006521)2.65743251
72synapsis (GO:0007129)2.65630556
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65530624
74translation (GO:0006412)2.63515636
75ncRNA catabolic process (GO:0034661)2.62534138
76tRNA metabolic process (GO:0006399)2.62192091
77translational termination (GO:0006415)2.60334432
78somatic hypermutation of immunoglobulin genes (GO:0016446)2.59940328
79somatic diversification of immune receptors via somatic mutation (GO:0002566)2.59940328
80cornea development in camera-type eye (GO:0061303)2.58962696
81intraciliary transport (GO:0042073)2.58788946
82negative regulation of DNA-dependent DNA replication (GO:2000104)2.58419888
83viral transcription (GO:0019083)2.58032020
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.57251524
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.56097375
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56097375
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56097375
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55975121
89negative regulation of ligase activity (GO:0051352)2.55975121
90translational elongation (GO:0006414)2.55614533
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.54759847
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.54759847
93positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.54362481
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.52308422
95proton transport (GO:0015992)2.51319264
96rRNA methylation (GO:0031167)2.49053144
97intracellular protein transmembrane import (GO:0044743)2.48100683
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47541988
99signal transduction involved in cell cycle checkpoint (GO:0072395)2.46977768
100histone exchange (GO:0043486)2.46347119

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.23962881
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.57884189
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.17257453
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.59082355
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.31303800
6VDR_22108803_ChIP-Seq_LS180_Human3.20118340
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17569463
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72535590
9EZH2_22144423_ChIP-Seq_EOC_Human2.60772408
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.59385884
11ZNF274_21170338_ChIP-Seq_K562_Hela2.38688697
12MYC_18940864_ChIP-ChIP_HL60_Human2.24051961
13VDR_23849224_ChIP-Seq_CD4+_Human2.23521192
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21302923
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.14547830
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11595363
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.99853670
18ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97746998
19FOXP3_21729870_ChIP-Seq_TREG_Human1.96377975
20ELK1_19687146_ChIP-ChIP_HELA_Human1.90676683
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87607737
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82955858
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73129006
24EWS_26573619_Chip-Seq_HEK293_Human1.69345094
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60842569
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60330376
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57102171
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.53465819
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51595150
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50831647
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49022232
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43480972
33IRF1_19129219_ChIP-ChIP_H3396_Human1.39666709
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37510903
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37154403
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.36173567
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34401002
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.32853277
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30729384
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.29303972
41TP53_22573176_ChIP-Seq_HFKS_Human1.27126202
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26619688
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26313315
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24936036
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24931736
46TTF2_22483619_ChIP-Seq_HELA_Human1.23800858
47GABP_19822575_ChIP-Seq_HepG2_Human1.22704742
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.21066268
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21066268
50EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20188412
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19688891
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16774074
53NANOG_20526341_ChIP-Seq_ESCs_Human1.14108793
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11955698
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11403514
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10042262
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09917932
58NCOR_22424771_ChIP-Seq_293T_Human1.09046245
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07482313
60HTT_18923047_ChIP-ChIP_STHdh_Human1.06798911
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05920326
62MYC_19829295_ChIP-Seq_ESCs_Human1.04997822
63TAF2_19829295_ChIP-Seq_ESCs_Human1.04869530
64FUS_26573619_Chip-Seq_HEK293_Human1.03772046
65RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02777567
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02142426
67GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02138651
68P300_19829295_ChIP-Seq_ESCs_Human1.01386353
69REST_21632747_ChIP-Seq_MESCs_Mouse1.00491645
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00243351
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99505924
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98059241
73FOXH1_21741376_ChIP-Seq_EPCs_Human0.97558203
74AR_20517297_ChIP-Seq_VCAP_Human0.97466709
75HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97349601
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96272789
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95786691
78TCF4_22108803_ChIP-Seq_LS180_Human0.95246084
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95200884
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95022427
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94993586
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94993586
83NANOG_19829295_ChIP-Seq_ESCs_Human0.94754344
84SOX2_19829295_ChIP-Seq_ESCs_Human0.94754344
85RBPJ_21746931_ChIP-Seq_IB4_Human0.94108502
86KDM5A_27292631_Chip-Seq_BREAST_Human0.93170543
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92643028
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91558919
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.91427665
90ER_23166858_ChIP-Seq_MCF-7_Human0.91027241
91SOX2_21211035_ChIP-Seq_LN229_Human0.90164934
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.89406821
93XRN2_22483619_ChIP-Seq_HELA_Human0.88502274
94ERA_21632823_ChIP-Seq_H3396_Human0.88087853
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87283493
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87162960
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87139810
98MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86960219
99TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86543750
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86483553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.88063764
2MP0002102_abnormal_ear_morphology3.29505178
3MP0000372_irregular_coat_pigmentation2.83998284
4MP0002736_abnormal_nociception_after2.70491816
5MP0008877_abnormal_DNA_methylation2.61365040
6MP0006072_abnormal_retinal_apoptosis2.54195271
7MP0008789_abnormal_olfactory_epithelium2.39233360
8MP0003786_premature_aging2.38006254
9MP0008007_abnormal_cellular_replicative2.36780171
10MP0005671_abnormal_response_to2.34638404
11MP0003136_yellow_coat_color2.32717870
12MP0003890_abnormal_embryonic-extraembry2.26555946
13MP0008058_abnormal_DNA_repair2.18316520
14MP0001968_abnormal_touch/_nociception2.14566444
15MP0005551_abnormal_eye_electrophysiolog2.08023637
16MP0004145_abnormal_muscle_electrophysio2.05784969
17MP0003787_abnormal_imprinting1.98390292
18MP0005499_abnormal_olfactory_system1.97727273
19MP0005394_taste/olfaction_phenotype1.97727273
20MP0008995_early_reproductive_senescence1.86281877
21MP0009379_abnormal_foot_pigmentation1.86064253
22MP0002938_white_spotting1.81205183
23MP0008872_abnormal_physiological_respon1.75879655
24MP0002653_abnormal_ependyma_morphology1.75413242
25MP0004142_abnormal_muscle_tone1.65837747
26MP0001986_abnormal_taste_sensitivity1.63416343
27MP0002837_dystrophic_cardiac_calcinosis1.60572535
28MP0001919_abnormal_reproductive_system1.55172945
29MP0001293_anophthalmia1.51325293
30MP0002095_abnormal_skin_pigmentation1.51000430
31MP0005253_abnormal_eye_physiology1.48154328
32MP0001727_abnormal_embryo_implantation1.47452237
33MP0003878_abnormal_ear_physiology1.47402451
34MP0005377_hearing/vestibular/ear_phenot1.47402451
35MP0009745_abnormal_behavioral_response1.44300479
36MP0004957_abnormal_blastocyst_morpholog1.39711210
37MP0000427_abnormal_hair_cycle1.37814327
38MP0003718_maternal_effect1.36089923
39MP0003011_delayed_dark_adaptation1.35548046
40MP0000778_abnormal_nervous_system1.32699345
41MP0009780_abnormal_chondrocyte_physiolo1.31013517
42MP0001485_abnormal_pinna_reflex1.30526989
43MP0002733_abnormal_thermal_nociception1.27389218
44MP0004885_abnormal_endolymph1.26724842
45MP0002638_abnormal_pupillary_reflex1.25754939
46MP0001905_abnormal_dopamine_level1.25141084
47MP0002163_abnormal_gland_morphology1.16758662
48MP0001984_abnormal_olfaction1.16342521
49MP0003693_abnormal_embryo_hatching1.13672571
50MP0006276_abnormal_autonomic_nervous1.13333811
51MP0002234_abnormal_pharynx_morphology1.11322120
52MP0010094_abnormal_chromosome_stability1.11300106
53MP0005389_reproductive_system_phenotype1.10395357
54MP0003646_muscle_fatigue1.09427980
55MP0008875_abnormal_xenobiotic_pharmacok1.08881484
56MP0005075_abnormal_melanosome_morpholog1.08603843
57MP0009046_muscle_twitch1.06378176
58MP0002557_abnormal_social/conspecific_i1.06238334
59MP0002272_abnormal_nervous_system1.05953114
60MP0006035_abnormal_mitochondrial_morpho1.04982938
61MP0000631_abnormal_neuroendocrine_gland1.04074997
62MP0005195_abnormal_posterior_eye1.02896907
63MP0002572_abnormal_emotion/affect_behav1.00997210
64MP0005423_abnormal_somatic_nervous1.00187102
65MP0003121_genomic_imprinting0.99902290
66MP0001970_abnormal_pain_threshold0.99083575
67MP0006036_abnormal_mitochondrial_physio0.98506652
68MP0005174_abnormal_tail_pigmentation0.98464172
69MP0008775_abnormal_heart_ventricle0.97753038
70MP0001486_abnormal_startle_reflex0.93870822
71MP0005084_abnormal_gallbladder_morpholo0.93687820
72MP0003186_abnormal_redox_activity0.91828345
73MP0003123_paternal_imprinting0.91466481
74MP0002751_abnormal_autonomic_nervous0.90573306
75MP0005645_abnormal_hypothalamus_physiol0.90460322
76MP0002067_abnormal_sensory_capabilities0.89755628
77MP0001529_abnormal_vocalization0.88087048
78MP0004742_abnormal_vestibular_system0.87872403
79MP0000955_abnormal_spinal_cord0.86969753
80MP0003195_calcinosis0.86631269
81MP0002752_abnormal_somatic_nervous0.85065564
82MP0002064_seizures0.80738315
83MP0005391_vision/eye_phenotype0.79666274
84MP0003635_abnormal_synaptic_transmissio0.78007476
85MP0001835_abnormal_antigen_presentation0.75918559
86MP0003111_abnormal_nucleus_morphology0.75761311
87MP0001440_abnormal_grooming_behavior0.75276458
88MP0005408_hypopigmentation0.73761078
89MP0003183_abnormal_peptide_metabolism0.72948348
90MP0004215_abnormal_myocardial_fiber0.72887822
91MP0002277_abnormal_respiratory_mucosa0.72783093
92MP0001963_abnormal_hearing_physiology0.71392864
93MP0005379_endocrine/exocrine_gland_phen0.69788495
94MP0003567_abnormal_fetal_cardiomyocyte0.68968703
95MP0000647_abnormal_sebaceous_gland0.68225680
96MP0003122_maternal_imprinting0.66753938
97MP0005410_abnormal_fertilization0.66597542
98MP0002063_abnormal_learning/memory/cond0.66384508
99MP0003137_abnormal_impulse_conducting0.66310734
100MP0001119_abnormal_female_reproductive0.66090419

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.59172166
2Abnormal mitochondria in muscle tissue (HP:0008316)4.16327233
3Congenital stationary night blindness (HP:0007642)3.98494141
4Mitochondrial inheritance (HP:0001427)3.89442498
5Progressive macrocephaly (HP:0004481)3.84693990
6Acute encephalopathy (HP:0006846)3.81984263
7Increased CSF lactate (HP:0002490)3.74462098
8Hepatocellular necrosis (HP:0001404)3.68491221
9Pancreatic fibrosis (HP:0100732)3.53757675
10Myokymia (HP:0002411)3.27912685
11Colon cancer (HP:0003003)3.23301946
12Hepatic necrosis (HP:0002605)3.05700654
13Abnormality of the labia minora (HP:0012880)2.95072030
14Cerebral edema (HP:0002181)2.91080895
15Pancreatic cysts (HP:0001737)2.85559257
16Abnormality of cells of the erythroid lineage (HP:0012130)2.84885902
17Increased hepatocellular lipid droplets (HP:0006565)2.83632638
18Nephronophthisis (HP:0000090)2.81867380
19Abnormal number of erythroid precursors (HP:0012131)2.78907779
20IgG deficiency (HP:0004315)2.72850789
21Lipid accumulation in hepatocytes (HP:0006561)2.66762657
22Abnormality of magnesium homeostasis (HP:0004921)2.66534299
23Reticulocytopenia (HP:0001896)2.65967969
24Optic disc pallor (HP:0000543)2.65463148
25Abnormality of the renal cortex (HP:0011035)2.65161230
26Aplastic anemia (HP:0001915)2.51644112
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48389368
28Abnormality of alanine metabolism (HP:0010916)2.48389368
29Hyperalaninemia (HP:0003348)2.48389368
30Aplasia/hypoplasia of the uterus (HP:0008684)2.48229852
31Increased serum lactate (HP:0002151)2.47384556
32Renal Fanconi syndrome (HP:0001994)2.44828800
33Abnormality of midbrain morphology (HP:0002418)2.42526670
34Molar tooth sign on MRI (HP:0002419)2.42526670
35Supernumerary spleens (HP:0009799)2.42299138
36True hermaphroditism (HP:0010459)2.42296014
37Pendular nystagmus (HP:0012043)2.42236661
38Tubular atrophy (HP:0000092)2.41776533
39Congenital, generalized hypertrichosis (HP:0004540)2.39401419
40Cerebral hypomyelination (HP:0006808)2.31758832
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29585548
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29585548
43Elevated erythrocyte sedimentation rate (HP:0003565)2.26866833
44Type II lissencephaly (HP:0007260)2.26711215
45Abolished electroretinogram (ERG) (HP:0000550)2.25934020
46Abnormal drinking behavior (HP:0030082)2.24173033
47Polydipsia (HP:0001959)2.24173033
48Abnormality of the renal medulla (HP:0100957)2.23796348
49Polyuria (HP:0000103)2.19923793
50Progressive microcephaly (HP:0000253)2.17400726
51Lactic acidosis (HP:0003128)2.16508458
52Macrocytic anemia (HP:0001972)2.16309173
53Absent septum pellucidum (HP:0001331)2.14533367
54Septo-optic dysplasia (HP:0100842)2.12704901
55Respiratory failure (HP:0002878)2.11510137
563-Methylglutaconic aciduria (HP:0003535)2.10328054
57Leukodystrophy (HP:0002415)2.09629635
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07438172
59Stenosis of the external auditory canal (HP:0000402)2.06326043
60Palpebral edema (HP:0100540)2.03830011
61Increased intramyocellular lipid droplets (HP:0012240)2.02609430
62Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.01072051
63Severe visual impairment (HP:0001141)1.99443068
64Constricted visual fields (HP:0001133)1.99179271
65Exercise intolerance (HP:0003546)1.98344382
66Methylmalonic acidemia (HP:0002912)1.96382443
67Abnormal hemoglobin (HP:0011902)1.96112094
68Congenital hepatic fibrosis (HP:0002612)1.95295002
69Oligodactyly (hands) (HP:0001180)1.92993469
70Lethargy (HP:0001254)1.92346916
71Adactyly (HP:0009776)1.92251723
72Abnormality of the septum pellucidum (HP:0007375)1.92058453
73Hypoproteinemia (HP:0003075)1.90446346
74Hypomagnesemia (HP:0002917)1.89172838
75Sclerocornea (HP:0000647)1.87590883
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87588387
77Delayed CNS myelination (HP:0002188)1.87198340
78Methylmalonic aciduria (HP:0012120)1.86258540
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85984698
80Hypoplasia of the uterus (HP:0000013)1.85380324
81Blindness (HP:0000618)1.83794188
82Dyschromatopsia (HP:0007641)1.83459291
83Fibular aplasia (HP:0002990)1.83436727
84Respiratory difficulties (HP:0002880)1.81469235
85Exertional dyspnea (HP:0002875)1.80589980
86CNS demyelination (HP:0007305)1.80544475
87T lymphocytopenia (HP:0005403)1.80459924
88Hypoplasia of the pons (HP:0012110)1.80191229
89Global brain atrophy (HP:0002283)1.78732998
90Prominent metopic ridge (HP:0005487)1.78470086
91Entropion (HP:0000621)1.77708807
92Furrowed tongue (HP:0000221)1.75727840
93Abnormality of the pons (HP:0007361)1.73781740
94Postaxial foot polydactyly (HP:0001830)1.73382167
95Cerebellar dysplasia (HP:0007033)1.72549666
96Abnormal rod and cone electroretinograms (HP:0008323)1.70970869
97Abnormal urine output (HP:0012590)1.68444935
98X-linked dominant inheritance (HP:0001423)1.68248175
99Type 2 muscle fiber atrophy (HP:0003554)1.66312714
100Abnormality of T cell number (HP:0011839)1.65886957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK13.47890568
2MAP3K113.16773307
3VRK23.08227090
4TXK2.95445641
5WNK42.60373200
6LATS12.48102448
7STK162.47239241
8ADRBK22.36154992
9MAP2K62.09913895
10NEK12.00748592
11BUB11.95421759
12FRK1.85939291
13CDC71.81947153
14MKNK21.80912156
15EIF2AK31.77383001
16DYRK21.74844197
17TNIK1.64872474
18TAOK31.62119474
19TRIM281.59569382
20ICK1.58104004
21GRK11.55493958
22MST41.50008660
23BMPR1B1.47115921
24VRK11.43846699
25WNK31.39436969
26OXSR11.35214677
27PLK31.30959778
28NTRK31.28459314
29STK391.25658597
30ZAK1.24560412
31ITK1.21842147
32MAP3K91.21136398
33ALK1.12858530
34PBK1.10835692
35ACVR1B1.10478166
36CAMKK21.10323202
37PRKCG1.09684316
38EIF2AK11.08409525
39TAF11.07317602
40PLK21.04985083
41MARK11.04582810
42PDK21.01409739
43MAP4K10.97966183
44STK30.97400983
45TSSK60.96431036
46MKNK10.95839614
47MINK10.95717080
48MAP4K20.94074930
49SRPK10.91796587
50MAP3K120.87764340
51CSNK1G10.87685552
52NME10.87080666
53SCYL20.84655240
54PRKCQ0.83401000
55IKBKE0.81320638
56PLK40.79098753
57NEK20.78090718
58CSNK1G30.77535045
59IKBKB0.77130865
60BRSK20.76048803
61BCKDK0.74117383
62PRKCI0.73035718
63EIF2AK20.72708189
64AURKA0.71150040
65CSNK1G20.69174644
66TEC0.67801553
67PHKG20.67161101
68PHKG10.67161101
69ADRBK10.66535957
70PLK10.65641439
71AURKB0.61798210
72STK40.56826912
73NLK0.56331049
74TLK10.54346453
75MAPK150.54204277
76INSRR0.52130416
77CSF1R0.48673933
78BTK0.48353638
79DAPK10.48310322
80PINK10.47740918
81CHEK20.44203919
82CSNK2A20.42310863
83CDK190.41027718
84CASK0.40728808
85PRKCD0.40612848
86PIK3CA0.40183802
87DYRK1A0.39038545
88SYK0.38367891
89CSNK1E0.37922755
90CSNK1A10.37476689
91LCK0.37345247
92PRKCA0.37259092
93PRKCE0.36972014
94TYRO30.36820524
95LYN0.36705344
96PIK3CG0.35683086
97CSNK1A1L0.34698960
98PRKG10.34195415
99PRKACA0.34063442
100CSNK2A10.33914180

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.84646626
2Proteasome_Homo sapiens_hsa030503.84491956
3Ribosome_Homo sapiens_hsa030103.48141802
4Parkinsons disease_Homo sapiens_hsa050123.25426526
5RNA polymerase_Homo sapiens_hsa030202.90927970
6Huntingtons disease_Homo sapiens_hsa050162.37060165
7Alzheimers disease_Homo sapiens_hsa050102.18191971
8Caffeine metabolism_Homo sapiens_hsa002322.07305330
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05610048
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03573884
11Primary immunodeficiency_Homo sapiens_hsa053401.93539250
12Non-homologous end-joining_Homo sapiens_hsa034501.92405815
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91923225
14Protein export_Homo sapiens_hsa030601.90950292
15Homologous recombination_Homo sapiens_hsa034401.87822314
16Cardiac muscle contraction_Homo sapiens_hsa042601.79632468
17RNA degradation_Homo sapiens_hsa030181.64567893
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62325006
19Mismatch repair_Homo sapiens_hsa034301.53952499
20One carbon pool by folate_Homo sapiens_hsa006701.53646602
21Basal transcription factors_Homo sapiens_hsa030221.51706158
22Propanoate metabolism_Homo sapiens_hsa006401.47618965
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47544959
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42463192
25Spliceosome_Homo sapiens_hsa030401.39966711
26Linoleic acid metabolism_Homo sapiens_hsa005911.39949022
27Nitrogen metabolism_Homo sapiens_hsa009101.35143223
28Nucleotide excision repair_Homo sapiens_hsa034201.30657148
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30651147
30Fanconi anemia pathway_Homo sapiens_hsa034601.30049767
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29648088
32Ovarian steroidogenesis_Homo sapiens_hsa049131.21883737
33Peroxisome_Homo sapiens_hsa041461.18658716
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18122936
35DNA replication_Homo sapiens_hsa030301.16230780
36RNA transport_Homo sapiens_hsa030131.13374562
37Selenocompound metabolism_Homo sapiens_hsa004501.13187656
38Purine metabolism_Homo sapiens_hsa002301.12917562
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12189650
40Butanoate metabolism_Homo sapiens_hsa006501.09920573
41Base excision repair_Homo sapiens_hsa034101.05464025
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.04556101
43Glutamatergic synapse_Homo sapiens_hsa047241.00624598
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99774082
45Pyrimidine metabolism_Homo sapiens_hsa002400.99591075
46Morphine addiction_Homo sapiens_hsa050320.94569959
47Nicotine addiction_Homo sapiens_hsa050330.89715073
48Phototransduction_Homo sapiens_hsa047440.85832033
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83578900
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81753226
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.80598421
52Steroid biosynthesis_Homo sapiens_hsa001000.80553462
53Circadian entrainment_Homo sapiens_hsa047130.76886459
54GABAergic synapse_Homo sapiens_hsa047270.72750616
55Fatty acid biosynthesis_Homo sapiens_hsa000610.72714316
56Folate biosynthesis_Homo sapiens_hsa007900.70140398
57Autoimmune thyroid disease_Homo sapiens_hsa053200.70091259
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69888748
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68014263
60Asthma_Homo sapiens_hsa053100.67898057
61Regulation of autophagy_Homo sapiens_hsa041400.67040789
62Retinol metabolism_Homo sapiens_hsa008300.66602267
63Salivary secretion_Homo sapiens_hsa049700.65885642
64Insulin secretion_Homo sapiens_hsa049110.64388171
65Fatty acid elongation_Homo sapiens_hsa000620.63851140
66Gastric acid secretion_Homo sapiens_hsa049710.61833521
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61801447
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60519272
69Olfactory transduction_Homo sapiens_hsa047400.59883117
70Allograft rejection_Homo sapiens_hsa053300.59100352
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57459059
72Tryptophan metabolism_Homo sapiens_hsa003800.57360991
73Fatty acid degradation_Homo sapiens_hsa000710.57014529
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56100743
75Metabolic pathways_Homo sapiens_hsa011000.56051737
76Oocyte meiosis_Homo sapiens_hsa041140.52108764
77Synaptic vesicle cycle_Homo sapiens_hsa047210.51042474
78Type I diabetes mellitus_Homo sapiens_hsa049400.50743088
79Collecting duct acid secretion_Homo sapiens_hsa049660.48057721
80Graft-versus-host disease_Homo sapiens_hsa053320.46078528
81Sulfur metabolism_Homo sapiens_hsa009200.45883395
82Antigen processing and presentation_Homo sapiens_hsa046120.45461303
83Sulfur relay system_Homo sapiens_hsa041220.44381252
84Ether lipid metabolism_Homo sapiens_hsa005650.42278013
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.41873644
86Pyruvate metabolism_Homo sapiens_hsa006200.40928064
87Thyroid hormone synthesis_Homo sapiens_hsa049180.40478724
88Pancreatic secretion_Homo sapiens_hsa049720.40238294
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39990526
90Arachidonic acid metabolism_Homo sapiens_hsa005900.39611898
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38528114
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38515683
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37856643
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34961760
95Chemical carcinogenesis_Homo sapiens_hsa052040.33378215
96Cholinergic synapse_Homo sapiens_hsa047250.30960337
97T cell receptor signaling pathway_Homo sapiens_hsa046600.30927256
98Fatty acid metabolism_Homo sapiens_hsa012120.29978275
99Taste transduction_Homo sapiens_hsa047420.29799491
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.28552458

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