PA2G4P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.27576223
2maturation of SSU-rRNA (GO:0030490)5.55620487
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.38132384
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.25849334
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.06836862
6ATP synthesis coupled proton transport (GO:0015986)5.06836862
7regulation of cellular respiration (GO:0043457)5.05306089
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.95984634
9cytidine deamination (GO:0009972)4.85012869
10cytidine metabolic process (GO:0046087)4.85012869
11cytidine catabolic process (GO:0006216)4.85012869
12nucleobase biosynthetic process (GO:0046112)4.64740372
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.53917579
14respiratory electron transport chain (GO:0022904)4.41898401
15chromatin remodeling at centromere (GO:0031055)4.41534657
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.39430171
17electron transport chain (GO:0022900)4.37755094
18CENP-A containing nucleosome assembly (GO:0034080)4.30919242
19purine nucleotide salvage (GO:0032261)4.28642462
20purine nucleobase biosynthetic process (GO:0009113)4.26417109
21ribosomal small subunit biogenesis (GO:0042274)4.23037448
22DNA strand elongation involved in DNA replication (GO:0006271)4.00191214
23pyrimidine ribonucleoside catabolic process (GO:0046133)3.99002616
24protein deneddylation (GO:0000338)3.93481624
25cullin deneddylation (GO:0010388)3.91459462
26chaperone-mediated protein transport (GO:0072321)3.90319993
27DNA replication checkpoint (GO:0000076)3.90241289
28telomere maintenance via semi-conservative replication (GO:0032201)3.88943793
29kinetochore assembly (GO:0051382)3.86061345
30postreplication repair (GO:0006301)3.81209671
31DNA strand elongation (GO:0022616)3.80045580
32ribosomal large subunit biogenesis (GO:0042273)3.77769726
33translesion synthesis (GO:0019985)3.68261546
34deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.62536767
35purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.62070841
36protein neddylation (GO:0045116)3.53724283
37negative regulation of telomere maintenance (GO:0032205)3.52268628
38purine deoxyribonucleotide catabolic process (GO:0009155)3.51031274
39somatic diversification of immune receptors via somatic mutation (GO:0002566)3.50264847
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.50264847
41rRNA modification (GO:0000154)3.45128237
42histone exchange (GO:0043486)3.41641584
43regulation of double-strand break repair via homologous recombination (GO:0010569)3.36280476
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.35455008
45mannosylation (GO:0097502)3.33428752
46adenosine metabolic process (GO:0046085)3.33213836
47viral transcription (GO:0019083)3.32128040
48translational termination (GO:0006415)3.27573728
49ribosomal small subunit assembly (GO:0000028)3.27525069
50protein-cofactor linkage (GO:0018065)3.27473901
51succinate metabolic process (GO:0006105)3.25077558
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.24475919
53DNA replication-dependent nucleosome assembly (GO:0006335)3.18775053
54DNA replication-dependent nucleosome organization (GO:0034723)3.18775053
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17199219
56translational elongation (GO:0006414)3.14554906
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.14141941
58NADH dehydrogenase complex assembly (GO:0010257)3.14141941
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14141941
60transcription from mitochondrial promoter (GO:0006390)3.12112002
61hydrogen ion transmembrane transport (GO:1902600)3.08489843
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08417546
63pseudouridine synthesis (GO:0001522)3.07886142
64deoxyribonucleotide catabolic process (GO:0009264)3.05953252
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05215242
66translation (GO:0006412)3.04537832
67telomere maintenance via recombination (GO:0000722)3.04226324
68kinetochore organization (GO:0051383)3.02613201
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01817211
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01817211
71DNA replication-independent nucleosome assembly (GO:0006336)3.01566185
72DNA replication-independent nucleosome organization (GO:0034724)3.01566185
73purine-containing compound salvage (GO:0043101)2.99965100
74ubiquinone biosynthetic process (GO:0006744)2.99462286
75tricarboxylic acid cycle (GO:0006099)2.96796726
76platelet dense granule organization (GO:0060155)2.95382172
77adaptation of signaling pathway (GO:0023058)2.93883946
78tongue development (GO:0043586)2.92906014
79ribonucleoprotein complex biogenesis (GO:0022613)2.92891688
80telomere maintenance via telomere lengthening (GO:0010833)2.92334508
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91992228
82deoxyribose phosphate catabolic process (GO:0046386)2.91935797
83positive regulation of uterine smooth muscle contraction (GO:0070474)2.90772315
84piRNA metabolic process (GO:0034587)2.90384038
85SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.89829715
86deoxyribonucleotide biosynthetic process (GO:0009263)2.89224825
87tolerance induction (GO:0002507)2.89034443
88oxidative phosphorylation (GO:0006119)2.88481978
89protein complex biogenesis (GO:0070271)2.88157833
90protein targeting to ER (GO:0045047)2.87022214
91cotranslational protein targeting to membrane (GO:0006613)2.84889824
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84088660
93proteasome assembly (GO:0043248)2.84003312
94GTP biosynthetic process (GO:0006183)2.83350255
95aerobic respiration (GO:0009060)2.83125547
96respiratory chain complex IV assembly (GO:0008535)2.83010279
97inner mitochondrial membrane organization (GO:0007007)2.82460878
98mitochondrial respiratory chain complex assembly (GO:0033108)2.82456865
99male meiosis I (GO:0007141)2.82078564
100AMP metabolic process (GO:0046033)2.81253095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.51274640
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.51517246
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.23014829
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.17913740
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95762201
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93378614
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.64161420
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52086094
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47182931
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46268644
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45984497
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.45972547
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.44439059
14ELK1_19687146_ChIP-ChIP_HELA_Human2.23229371
15EZH2_22144423_ChIP-Seq_EOC_Human2.13078028
16FOXP3_21729870_ChIP-Seq_TREG_Human2.07801998
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.00166987
18E2F7_22180533_ChIP-Seq_HELA_Human11.9342598
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.99492218
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.93204070
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92651077
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89784622
23VDR_23849224_ChIP-Seq_CD4+_Human1.89638246
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84556250
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.83005106
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82355278
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81861601
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79109375
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72544353
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68271299
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66848413
32IGF1R_20145208_ChIP-Seq_DFB_Human1.64236657
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60880723
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56471992
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.55901544
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53821394
37IRF1_19129219_ChIP-ChIP_H3396_Human1.53179436
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52296942
39DCP1A_22483619_ChIP-Seq_HELA_Human1.49635629
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44660702
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44660702
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44660702
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44100282
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.43364342
45MYC_18940864_ChIP-ChIP_HL60_Human1.41165041
46GABP_19822575_ChIP-Seq_HepG2_Human1.38959880
47ZNF274_21170338_ChIP-Seq_K562_Hela1.31501264
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30291495
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26930732
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24642931
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.24137325
52EWS_26573619_Chip-Seq_HEK293_Human1.23701181
53TTF2_22483619_ChIP-Seq_HELA_Human1.20043043
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19933093
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.18658166
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16599603
57FUS_26573619_Chip-Seq_HEK293_Human1.14927695
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11891067
59XRN2_22483619_ChIP-Seq_HELA_Human1.10791016
60VDR_22108803_ChIP-Seq_LS180_Human1.10765094
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07874945
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.06867190
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.04329289
64ERG_20517297_ChIP-Seq_VCAP_Human0.99703879
65SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98705175
66TP53_22573176_ChIP-Seq_HFKS_Human0.98057418
67HTT_18923047_ChIP-ChIP_STHdh_Human0.96791391
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95726798
69ELK1_22589737_ChIP-Seq_MCF10A_Human0.95561929
70SALL1_21062744_ChIP-ChIP_HESCs_Human0.93542777
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93026697
72AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89811551
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86526500
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86423898
75MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85643891
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84094240
77SOX2_19829295_ChIP-Seq_ESCs_Human0.83859475
78NANOG_19829295_ChIP-Seq_ESCs_Human0.83859475
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80692037
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80139507
81P300_19829295_ChIP-Seq_ESCs_Human0.80101605
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79621536
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79075800
84NANOG_16153702_ChIP-ChIP_HESCs_Human0.77815766
85TAF2_19829295_ChIP-Seq_ESCs_Human0.77028853
86NANOG_18555785_ChIP-Seq_MESCs_Mouse0.76226250
87NANOG_20526341_ChIP-Seq_ESCs_Human0.75414623
88FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75124853
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.75124853
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71516454
91NCOR_22424771_ChIP-Seq_293T_Human0.71018867
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.70783647
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70069076
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69178664
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.68484723
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.67985272
97CTCF_18555785_ChIP-Seq_MESCs_Mouse0.67849449
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.67781931
99AR_20517297_ChIP-Seq_VCAP_Human0.67318239
100SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.67316231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.17474792
2MP0006292_abnormal_olfactory_placode3.69788610
3MP0008058_abnormal_DNA_repair3.60095288
4MP0001346_abnormal_lacrimal_gland3.57665947
5MP0009697_abnormal_copulation3.30213403
6MP0010094_abnormal_chromosome_stability2.52939756
7MP0004957_abnormal_blastocyst_morpholog2.50003972
8MP0003806_abnormal_nucleotide_metabolis2.45250765
9MP0008007_abnormal_cellular_replicative2.41515758
10MP0003693_abnormal_embryo_hatching2.38002687
11MP0005408_hypopigmentation2.35622553
12MP0005075_abnormal_melanosome_morpholog2.19640273
13MP0008789_abnormal_olfactory_epithelium2.18428572
14MP0001293_anophthalmia2.06896625
15MP0002736_abnormal_nociception_after1.98880673
16MP0002653_abnormal_ependyma_morphology1.96358660
17MP0005174_abnormal_tail_pigmentation1.92334680
18MP0003880_abnormal_central_pattern1.91701493
19MP0003718_maternal_effect1.90314824
20MP0002095_abnormal_skin_pigmentation1.89470704
21MP0002163_abnormal_gland_morphology1.89264437
22MP0006036_abnormal_mitochondrial_physio1.85045767
23MP0005083_abnormal_biliary_tract1.81883504
24MP0002160_abnormal_reproductive_system1.81855155
25MP0003111_abnormal_nucleus_morphology1.79824680
26MP0000015_abnormal_ear_pigmentation1.77134420
27MP0005551_abnormal_eye_electrophysiolog1.74860473
28MP0001919_abnormal_reproductive_system1.74497667
29MP0008877_abnormal_DNA_methylation1.73962329
30MP0006035_abnormal_mitochondrial_morpho1.72705089
31MP0003252_abnormal_bile_duct1.70643282
32MP0005389_reproductive_system_phenotype1.66275890
33MP0003646_muscle_fatigue1.63015905
34MP0003950_abnormal_plasma_membrane1.60873613
35MP0005394_taste/olfaction_phenotype1.55750733
36MP0005499_abnormal_olfactory_system1.55750733
37MP0008932_abnormal_embryonic_tissue1.50483486
38MP0000372_irregular_coat_pigmentation1.49748664
39MP0000569_abnormal_digit_pigmentation1.42097265
40MP0001324_abnormal_eye_pigmentation1.39635979
41MP0003077_abnormal_cell_cycle1.37706386
42MP0001485_abnormal_pinna_reflex1.30520326
43MP0000749_muscle_degeneration1.29925943
44MP0004145_abnormal_muscle_electrophysio1.28225164
45MP0002234_abnormal_pharynx_morphology1.23657413
46MP0002210_abnormal_sex_determination1.23620878
47MP0001968_abnormal_touch/_nociception1.21588421
48MP0003195_calcinosis1.21118032
49MP0010030_abnormal_orbit_morphology1.18564383
50MP0002938_white_spotting1.16540205
51MP0000566_synostosis1.16250837
52MP0001529_abnormal_vocalization1.16235945
53MP0001188_hyperpigmentation1.13395509
54MP0001929_abnormal_gametogenesis1.10772217
55MP0000751_myopathy1.09781796
56MP0006072_abnormal_retinal_apoptosis1.09524187
57MP0005360_urolithiasis1.08890023
58MP0001177_atelectasis1.07012164
59MP0000747_muscle_weakness0.98029376
60MP0004885_abnormal_endolymph0.97906980
61MP0005379_endocrine/exocrine_gland_phen0.97704144
62MP0005248_abnormal_Harderian_gland0.97618779
63MP0002090_abnormal_vision0.97205089
64MP0001764_abnormal_homeostasis0.97151410
65MP0005195_abnormal_posterior_eye0.95713269
66MP0001986_abnormal_taste_sensitivity0.94609211
67MP0005377_hearing/vestibular/ear_phenot0.93686053
68MP0003878_abnormal_ear_physiology0.93686053
69MP0005671_abnormal_response_to0.90916772
70MP0003186_abnormal_redox_activity0.90504954
71MP0008872_abnormal_physiological_respon0.89961246
72MP0003567_abnormal_fetal_cardiomyocyte0.87443868
73MP0003136_yellow_coat_color0.87285980
74MP0005085_abnormal_gallbladder_physiolo0.84570805
75MP0002837_dystrophic_cardiac_calcinosis0.82183535
76MP0001145_abnormal_male_reproductive0.81139470
77MP0000653_abnormal_sex_gland0.80923019
78MP0009745_abnormal_behavioral_response0.79805592
79MP0001119_abnormal_female_reproductive0.79442149
80MP0000427_abnormal_hair_cycle0.78793121
81MP0009053_abnormal_anal_canal0.77038979
82MP0003011_delayed_dark_adaptation0.77010810
83MP0002272_abnormal_nervous_system0.76447365
84MP0008875_abnormal_xenobiotic_pharmacok0.76373727
85MP0005266_abnormal_metabolism0.75244269
86MP0001486_abnormal_startle_reflex0.75151052
87MP0004147_increased_porphyrin_level0.74953245
88MP0003941_abnormal_skin_development0.73198592
89MP0000049_abnormal_middle_ear0.72771248
90MP0003698_abnormal_male_reproductive0.72722623
91MP0005197_abnormal_uvea_morphology0.71777380
92MP0002277_abnormal_respiratory_mucosa0.71650737
93MP0001501_abnormal_sleep_pattern0.70515848
94MP0005084_abnormal_gallbladder_morpholo0.66626133
95MP0002233_abnormal_nose_morphology0.65873267
96MP0000631_abnormal_neuroendocrine_gland0.65711223
97MP0005391_vision/eye_phenotype0.65440234
98MP0005636_abnormal_mineral_homeostasis0.64866607
99MP0002184_abnormal_innervation0.62939618
100MP0009046_muscle_twitch0.62804490

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)5.35876243
2Reticulocytopenia (HP:0001896)4.99140965
3Abnormality of B cell number (HP:0010975)4.80673304
4Abnormality of alanine metabolism (HP:0010916)3.85021848
5Hyperalaninemia (HP:0003348)3.85021848
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.85021848
7Acute encephalopathy (HP:0006846)3.78430244
8IgM deficiency (HP:0002850)3.73762393
9Acute necrotizing encephalopathy (HP:0006965)3.68831260
10Abnormal mitochondria in muscle tissue (HP:0008316)3.66269114
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.49209901
12Mitochondrial inheritance (HP:0001427)3.06880321
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06129476
14Increased IgM level (HP:0003496)3.02165474
15Absent thumb (HP:0009777)3.01079161
16Duplicated collecting system (HP:0000081)2.99152255
17Chromsome breakage (HP:0040012)2.96980387
18Pancytopenia (HP:0001876)2.87242799
19Increased CSF lactate (HP:0002490)2.85833478
20Progressive macrocephaly (HP:0004481)2.85703567
21Abnormality of the renal collecting system (HP:0004742)2.83405079
22Abnormality of DNA repair (HP:0003254)2.81199197
23Delayed epiphyseal ossification (HP:0002663)2.79310925
24Birth length less than 3rd percentile (HP:0003561)2.77129222
25Abnormality of the labia minora (HP:0012880)2.75743662
26IgG deficiency (HP:0004315)2.65778248
27Hyperglycinuria (HP:0003108)2.63416695
28Autoimmune thrombocytopenia (HP:0001973)2.60018833
29Hypoplasia of the capital femoral epiphysis (HP:0003090)2.55950428
30Chronic bronchitis (HP:0004469)2.55792514
31Hyperglycinemia (HP:0002154)2.55541271
32Hepatic necrosis (HP:0002605)2.53840775
33Abnormality of serum amino acid levels (HP:0003112)2.50671027
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.49662869
35Elevated erythrocyte sedimentation rate (HP:0003565)2.47726476
36Colon cancer (HP:0003003)2.43209426
37Meckel diverticulum (HP:0002245)2.42643897
383-Methylglutaconic aciduria (HP:0003535)2.40811020
39Abnormal hair whorl (HP:0010721)2.40191170
40Hepatocellular necrosis (HP:0001404)2.38096867
41Abnormal respiratory motile cilium physiology (HP:0012261)2.36735725
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29732128
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29732128
44Retinal atrophy (HP:0001105)2.28430512
45Lactic acidosis (HP:0003128)2.27942279
46Severe combined immunodeficiency (HP:0004430)2.26243791
47Abnormality of the ileum (HP:0001549)2.26113245
48Macrocytic anemia (HP:0001972)2.20510643
49Cerebral edema (HP:0002181)2.20353020
50Radial bowing (HP:0002986)2.16861312
51Autoimmune hemolytic anemia (HP:0001890)2.15627784
52Increased serum lactate (HP:0002151)2.14051525
53Respiratory failure (HP:0002878)2.13108551
54Hypoplasia of the radius (HP:0002984)2.12758971
55Type II lissencephaly (HP:0007260)2.12091153
56Cleft eyelid (HP:0000625)2.10889218
57Progressive microcephaly (HP:0000253)2.10794959
58Fibular aplasia (HP:0002990)2.10290408
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08512572
60Abnormality of the preputium (HP:0100587)2.03386506
61Increased intramyocellular lipid droplets (HP:0012240)2.02251255
62Abnormality of cells of the erythroid lineage (HP:0012130)2.02240036
63Congenital stationary night blindness (HP:0007642)2.02013144
64Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.01604499
65Absent epiphyses (HP:0010577)2.01604499
66Abnormality of chromosome stability (HP:0003220)2.00688172
67Absent/shortened dynein arms (HP:0200106)1.98707824
68Dynein arm defect of respiratory motile cilia (HP:0012255)1.98707824
69Methylmalonic aciduria (HP:0012120)1.98058481
70Ectopic kidney (HP:0000086)1.96810584
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93083398
72Septo-optic dysplasia (HP:0100842)1.92813585
73Limb hypertonia (HP:0002509)1.92308115
74Abnormal ciliary motility (HP:0012262)1.91730278
75Optic nerve hypoplasia (HP:0000609)1.90549897
76Short thumb (HP:0009778)1.90523012
77Abnormality of magnesium homeostasis (HP:0004921)1.89806371
78Clubbing of toes (HP:0100760)1.89385140
79Type 2 muscle fiber atrophy (HP:0003554)1.88589420
80Abnormality of serine family amino acid metabolism (HP:0010894)1.86307804
81Abnormality of glycine metabolism (HP:0010895)1.86307804
82Abnormality of pyrimidine metabolism (HP:0004353)1.86287953
83Duplication of thumb phalanx (HP:0009942)1.82452105
84Type I transferrin isoform profile (HP:0003642)1.78553467
85Oligodactyly (hands) (HP:0001180)1.77328439
86Optic disc pallor (HP:0000543)1.77321824
87Cellular immunodeficiency (HP:0005374)1.75859773
88Combined immunodeficiency (HP:0005387)1.75704990
89Abnormal number of erythroid precursors (HP:0012131)1.74748171
90Abnormality of the pons (HP:0007361)1.74722098
91Retinal dysplasia (HP:0007973)1.73584809
92Eosinophilia (HP:0001880)1.72158814
93Pallor (HP:0000980)1.72066872
94Hypomagnesemia (HP:0002917)1.71528552
95Gonadotropin excess (HP:0000837)1.71159328
96Aplasia involving forearm bones (HP:0009822)1.70790499
97Absent forearm bone (HP:0003953)1.70790499
98Mesangial abnormality (HP:0001966)1.70701776
99Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68713273
100Inability to walk (HP:0002540)1.68647423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.17201718
2BUB13.90163656
3MST43.45612284
4TLK12.94399237
5VRK22.74051091
6WNK42.44729733
7TRIM282.44687052
8VRK12.30656950
9KDR2.30272616
10MAP3K122.24130408
11PLK42.19254532
12NEK12.08642986
13STK392.01076691
14WEE11.97402081
15OXSR11.92549581
16MAPKAPK31.92436691
17CDC71.88085609
18OBSCN1.81560242
19NUAK11.74779931
20BMPR1B1.74779282
21CDK191.73122399
22CSNK1G11.69589452
23BCR1.57157064
24CSNK1G31.48367052
25TXK1.35253311
26ADRBK21.34426122
27CSNK1A1L1.28883150
28CSNK1G21.27579090
29MAP3K91.24808723
30TAF11.19725282
31PLK31.14112831
32CDK151.12688418
33CDK181.11751742
34ATR1.10035902
35GRK11.09838330
36KSR11.09350640
37PDK21.06345185
38TESK21.04309270
39PBK1.01775711
40CDK11A1.00010295
41PLK10.99298544
42PRKCI0.99002719
43STK160.98519188
44PINK10.97743029
45WNK10.96465143
46ABL20.95244105
47CDK140.94355540
48AURKB0.94059533
49WNK30.84679204
50CHEK20.82757936
51DYRK20.81571082
52ITK0.81179677
53ARAF0.80254813
54AURKA0.79560917
55PAK60.78933171
56NME10.78904337
57TTK0.78602650
58LIMK10.76926236
59KSR20.74775037
60DAPK10.73561452
61IKBKE0.73059930
62PNCK0.72767781
63TEC0.72220984
64TIE10.71269534
65ADRBK10.70822370
66TSSK60.69291407
67MAPK130.67881140
68NLK0.66548433
69PIM10.65874807
70BCKDK0.64491489
71MAP3K110.63971035
72MKNK20.62845799
73ACVR1B0.62450422
74PRKCG0.61926971
75PTK2B0.57981290
76PHKG20.54799388
77PHKG10.54799388
78CAMK10.51938923
79STK110.51868157
80CSNK1A10.51072568
81MOS0.50622603
82CSNK2A10.50055090
83PLK20.49459003
84MAPK110.49187022
85BRSK10.48073877
86PAK30.47744728
87CSNK2A20.47329469
88MUSK0.44715908
89FRK0.42860680
90DYRK1A0.42847061
91PAK10.42127879
92INSRR0.41177256
93RAF10.40748072
94CHEK10.38576741
95MARK30.37172852
96PRKCE0.33416404
97CSNK1E0.33297466
98MAPKAPK50.32858574
99RPS6KA50.32497319
100CDK40.32051966

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.95140506
2DNA replication_Homo sapiens_hsa030303.73177503
3Proteasome_Homo sapiens_hsa030503.55336685
4Ribosome_Homo sapiens_hsa030103.51040696
5Parkinsons disease_Homo sapiens_hsa050123.26585221
6Mismatch repair_Homo sapiens_hsa034302.94848862
7Propanoate metabolism_Homo sapiens_hsa006402.60986100
8Huntingtons disease_Homo sapiens_hsa050162.52935876
9Primary immunodeficiency_Homo sapiens_hsa053402.44622464
10Alzheimers disease_Homo sapiens_hsa050102.28550194
11Homologous recombination_Homo sapiens_hsa034402.27506687
12One carbon pool by folate_Homo sapiens_hsa006702.24721851
13Base excision repair_Homo sapiens_hsa034102.24287578
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18284864
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.17552943
16Fanconi anemia pathway_Homo sapiens_hsa034602.17020631
17RNA polymerase_Homo sapiens_hsa030202.09449186
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.00098823
19Nucleotide excision repair_Homo sapiens_hsa034201.99891043
20Cardiac muscle contraction_Homo sapiens_hsa042601.91492098
21Non-homologous end-joining_Homo sapiens_hsa034501.88990106
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.85751035
23Phototransduction_Homo sapiens_hsa047441.77250724
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72189539
25Pyrimidine metabolism_Homo sapiens_hsa002401.68207675
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62017220
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58497076
28Pyruvate metabolism_Homo sapiens_hsa006201.50013909
29RNA degradation_Homo sapiens_hsa030181.46393254
30Fatty acid elongation_Homo sapiens_hsa000621.41164375
31Folate biosynthesis_Homo sapiens_hsa007901.34073768
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31156857
33Basal transcription factors_Homo sapiens_hsa030221.27519698
34Protein export_Homo sapiens_hsa030601.20083935
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19775644
36Purine metabolism_Homo sapiens_hsa002301.13132507
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.07706286
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04782031
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01151776
40Glutathione metabolism_Homo sapiens_hsa004800.99143981
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97624218
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96137025
43Cell cycle_Homo sapiens_hsa041100.95332090
44Linoleic acid metabolism_Homo sapiens_hsa005910.92828082
45Carbon metabolism_Homo sapiens_hsa012000.91828864
46Spliceosome_Homo sapiens_hsa030400.90153316
47Selenocompound metabolism_Homo sapiens_hsa004500.87574862
48RNA transport_Homo sapiens_hsa030130.87245687
49Nitrogen metabolism_Homo sapiens_hsa009100.86355031
50Butanoate metabolism_Homo sapiens_hsa006500.86071132
51Fatty acid metabolism_Homo sapiens_hsa012120.76707283
52Tryptophan metabolism_Homo sapiens_hsa003800.76480310
53Fatty acid degradation_Homo sapiens_hsa000710.73476509
54Metabolic pathways_Homo sapiens_hsa011000.72706663
55Peroxisome_Homo sapiens_hsa041460.70464138
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69734479
57p53 signaling pathway_Homo sapiens_hsa041150.66919989
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65377756
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64748602
60Caffeine metabolism_Homo sapiens_hsa002320.61457658
61Olfactory transduction_Homo sapiens_hsa047400.60424491
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.58833015
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.57878580
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54645193
65Arginine and proline metabolism_Homo sapiens_hsa003300.53020144
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52206932
67Steroid biosynthesis_Homo sapiens_hsa001000.51332648
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50244445
69Ether lipid metabolism_Homo sapiens_hsa005650.50161667
70beta-Alanine metabolism_Homo sapiens_hsa004100.50084979
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40856147
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39304350
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.38969063
74Biosynthesis of amino acids_Homo sapiens_hsa012300.37838873
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34690446
76Arachidonic acid metabolism_Homo sapiens_hsa005900.32770151
77Chemical carcinogenesis_Homo sapiens_hsa052040.32678510
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.30728097
79Fat digestion and absorption_Homo sapiens_hsa049750.30581081
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30576221
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29038577
82Retinol metabolism_Homo sapiens_hsa008300.26800334
83T cell receptor signaling pathway_Homo sapiens_hsa046600.26686267
84Nicotine addiction_Homo sapiens_hsa050330.23260348
85Oocyte meiosis_Homo sapiens_hsa041140.21890623
86Arginine biosynthesis_Homo sapiens_hsa002200.21257694
87Regulation of autophagy_Homo sapiens_hsa041400.20241123
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19177036
89Histidine metabolism_Homo sapiens_hsa003400.17039906
90Systemic lupus erythematosus_Homo sapiens_hsa053220.15742915
91Hematopoietic cell lineage_Homo sapiens_hsa046400.14284762
92Tyrosine metabolism_Homo sapiens_hsa003500.13380547
93Collecting duct acid secretion_Homo sapiens_hsa049660.12758928
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.12593786
95Mineral absorption_Homo sapiens_hsa049780.12089161
96Serotonergic synapse_Homo sapiens_hsa047260.11941790
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11486752
98Hedgehog signaling pathway_Homo sapiens_hsa043400.11359467
99Morphine addiction_Homo sapiens_hsa050320.09525038
100Basal cell carcinoma_Homo sapiens_hsa052170.09248063

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