ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.23106582
2	cytidine deamination (GO:0009972)	5.95337027
3	cytidine metabolic process (GO:0046087)	5.95337027
4	cytidine catabolic process (GO:0006216)	5.95337027
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.82430046
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.15024007
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.12383874
8	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.07152810
9	ATP synthesis coupled proton transport (GO:0015986)	4.63613765
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.63613765
11	protein complex biogenesis (GO:0070271)	4.44898086
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.29536041
13	protein-cofactor linkage (GO:0018065)	4.13303915
14	mitochondrial respiratory chain complex assembly (GO:0033108)	3.97623726
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.90799977
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.90799977
17	NADH dehydrogenase complex assembly (GO:0010257)	3.90799977
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.79713338
19	positive regulation of protein homodimerization activity (GO:0090073)	3.79231857
20	respiratory electron transport chain (GO:0022904)	3.70873311
21	electron transport chain (GO:0022900)	3.68193177
22	regulation of cilium movement (GO:0003352)	3.55296792
23	respiratory chain complex IV assembly (GO:0008535)	3.53592122
24	negative regulation by host of viral transcription (GO:0043922)	3.50651599
25	chaperone-mediated protein transport (GO:0072321)	3.45088982
26	cytochrome complex assembly (GO:0017004)	3.14912832
27	termination of RNA polymerase III transcription (GO:0006386)	3.14848287
28	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.14848287
29	cellular ketone body metabolic process (GO:0046950)	3.11429221
30	dopamine transport (GO:0015872)	3.10896573
31	proteasome assembly (GO:0043248)	3.06221289
32	axoneme assembly (GO:0035082)	2.98078297
33	DNA demethylation (GO:0080111)	2.94632457
34	pseudouridine synthesis (GO:0001522)	2.92964435
35	intracellular protein transmembrane import (GO:0044743)	2.91404462
36	oxidative demethylation (GO:0070989)	2.90395855
37	nonmotile primary cilium assembly (GO:0035058)	2.85641327
38	estrogen biosynthetic process (GO:0006703)	2.85114830
39	regulation of cellular amino acid metabolic process (GO:0006521)	2.84471928
40	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.82330139
41	recombinational repair (GO:0000725)	2.80781475
42	regulation of glucokinase activity (GO:0033131)	2.79939913
43	regulation of hexokinase activity (GO:1903299)	2.79939913
44	startle response (GO:0001964)	2.78631347
45	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.75390392
46	preassembly of GPI anchor in ER membrane (GO:0016254)	2.73998160
47	ketone body metabolic process (GO:1902224)	2.72085316
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.70354438
49	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.70202687
50	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.70202687
51	lactate metabolic process (GO:0006089)	2.69787507
52	negative regulation of ligase activity (GO:0051352)	2.68180814
53	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.68180814
54	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.64356516
55	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.62778345
56	double-strand break repair via homologous recombination (GO:0000724)	2.61879204
57	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.58997636
58	mitotic metaphase plate congression (GO:0007080)	2.58636695
59	detection of light stimulus involved in visual perception (GO:0050908)	2.55896099
60	detection of light stimulus involved in sensory perception (GO:0050962)	2.55896099
61	ribosomal small subunit assembly (GO:0000028)	2.55868739
62	pyrimidine nucleoside catabolic process (GO:0046135)	2.55310973
63	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.54756220
64	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.53158498
65	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.53158498
66	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.51826932
67	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.51826932
68	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.51826932
69	reciprocal DNA recombination (GO:0035825)	2.51743776
70	reciprocal meiotic recombination (GO:0007131)	2.51743776
71	ATP biosynthetic process (GO:0006754)	2.51573917
72	microtubule severing (GO:0051013)	2.51435949
73	hydrogen ion transmembrane transport (GO:1902600)	2.48758336
74	centriole replication (GO:0007099)	2.46078535
75	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.45896675
76	DNA double-strand break processing (GO:0000729)	2.43710673
77	metaphase plate congression (GO:0051310)	2.43222199
78	left/right axis specification (GO:0070986)	2.42293708
79	protein peptidyl-prolyl isomerization (GO:0000413)	2.41015453
80	negative regulation of transcription by competitive promoter binding (GO:0010944)	2.40104573
81	autophagic vacuole fusion (GO:0000046)	2.39216764
82	urate metabolic process (GO:0046415)	2.37358422
83	proton transport (GO:0015992)	2.36547177
84	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.36364906
85	transcription from RNA polymerase III promoter (GO:0006383)	2.35997876
86	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.35781549
87	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.35781549
88	epithelial cilium movement (GO:0003351)	2.35587371
89	endocrine pancreas development (GO:0031018)	2.35184520
90	response to pheromone (GO:0019236)	2.33971651
91	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.33432559
92	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.33322624
93	T cell migration (GO:0072678)	2.33173345
94	cellular response to zinc ion (GO:0071294)	2.33132400
95	GPI anchor metabolic process (GO:0006505)	2.33071021
96	kinetochore assembly (GO:0051382)	2.31688706
97	otic vesicle formation (GO:0030916)	2.31436711
98	hydrogen transport (GO:0006818)	2.30399811
99	negative regulation of execution phase of apoptosis (GO:1900118)	2.27886642
100	axonemal dynein complex assembly (GO:0070286)	2.27325041

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.52210457
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.08441938
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.02687791
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.00877843
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.97280959
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.89513815
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.78071365
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.64151882
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.56961256
10	VDR_22108803_ChIP-Seq_LS180_Human	2.31412607
11	EWS_26573619_Chip-Seq_HEK293_Human	2.17290998
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.12149943
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.10340657
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06008337
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.00965980
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.97326228
17	GBX2_23144817_ChIP-Seq_PC3_Human	1.92500800
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.87520848
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.86783701
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.86571278
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.85912254
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.84605813
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.84413368
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.83976601
25	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.76818150
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73615830
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.67188097
28	EZH2_22144423_ChIP-Seq_EOC_Human	1.65834255
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.63840326
30	P300_19829295_ChIP-Seq_ESCs_Human	1.62362319
31	FUS_26573619_Chip-Seq_HEK293_Human	1.61741650
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.57709884
33	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.53739494
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52371331
35	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.50969039
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.50030796
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.46786358
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.46231827
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42434751
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42434751
41	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.40290548
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35868604
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35236917
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35236917
45	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.34343256
46	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.33088450
47	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.31839446
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.30151777
49	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.29265444
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28064319
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.27474489
52	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.26522723
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.26050021
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26050021
55	* NCOR_22424771_ChIP-Seq_293T_Human	1.26011751
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.24478492
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24065356
58	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.23283473
59	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.23014597
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.22710754
61	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.22307638
62	GATA3_26560356_Chip-Seq_TH2_Human	1.21584320
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.15429824
64	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15231214
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.14299566
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10879626
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10341194
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10207897
69	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.09313973
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09035119
71	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.06166274
72	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06092535
73	AR_20517297_ChIP-Seq_VCAP_Human	1.05231983
74	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04868025
75	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.04690870
76	IGF1R_20145208_ChIP-Seq_DFB_Human	1.04413880
77	NFYB_21822215_ChIP-Seq_K562_Human	1.04251363
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03947831
79	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02709449
80	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.02605018
81	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02536483
82	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02464572
83	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02091507
84	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.01295537
85	ERG_20517297_ChIP-Seq_VCAP_Human	1.01133734
86	HTT_18923047_ChIP-ChIP_STHdh_Human	1.01095010
87	IRF1_19129219_ChIP-ChIP_H3396_Human	1.01041577
88	PHF8_20622853_ChIP-Seq_HELA_Human	1.00800097
89	BCAT_22108803_ChIP-Seq_LS180_Human	0.99713378
90	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.99170071
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98106999
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97696359
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.97570755
94	P300_18555785_Chip-Seq_ESCs_Mouse	0.95867675
95	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.95315741
96	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.95071052
97	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95062309
98	* FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95056647
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.94879588
100	GATA3_26560356_Chip-Seq_TH1_Human	0.94873538

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.27576922
2	MP0005671_abnormal_response_to	3.22640174
3	MP0008877_abnormal_DNA_methylation	2.85889662
4	MP0005645_abnormal_hypothalamus_physiol	2.65873570
5	MP0000372_irregular_coat_pigmentation	2.54698735
6	MP0003787_abnormal_imprinting	2.46867769
7	MP0006292_abnormal_olfactory_placode	2.36331478
8	MP0002938_white_spotting	2.20818558
9	MP0005075_abnormal_melanosome_morpholog	2.11567641
10	MP0002837_dystrophic_cardiac_calcinosis	2.07070892
11	MP0005174_abnormal_tail_pigmentation	2.00897222
12	MP0008789_abnormal_olfactory_epithelium	1.96354138
13	MP0008875_abnormal_xenobiotic_pharmacok	1.95652248
14	MP0002163_abnormal_gland_morphology	1.95181409
15	MP0001984_abnormal_olfaction	1.90380270
16	MP0008872_abnormal_physiological_respon	1.75368452
17	MP0005379_endocrine/exocrine_gland_phen	1.73508744
18	MP0006072_abnormal_retinal_apoptosis	1.71951074
19	MP0001835_abnormal_antigen_presentation	1.68875856
20	MP0005551_abnormal_eye_electrophysiolog	1.65264136
21	MP0009785_altered_susceptibility_to	1.63437245
22	MP0000427_abnormal_hair_cycle	1.61009860
23	MP0001485_abnormal_pinna_reflex	1.60725628
24	MP0004885_abnormal_endolymph	1.58950706
25	MP0002102_abnormal_ear_morphology	1.54302349
26	MP0008995_early_reproductive_senescence	1.53991223
27	MP0008961_abnormal_basal_metabolism	1.51157478
28	MP0002653_abnormal_ependyma_morphology	1.48159946
29	MP0003806_abnormal_nucleotide_metabolis	1.47297959
30	MP0001986_abnormal_taste_sensitivity	1.45254630
31	MP0002693_abnormal_pancreas_physiology	1.43292579
32	MP0009379_abnormal_foot_pigmentation	1.43096727
33	MP0002095_abnormal_skin_pigmentation	1.41050293
34	MP0008058_abnormal_DNA_repair	1.36658624
35	MP0003195_calcinosis	1.35821562
36	MP0001873_stomach_inflammation	1.34377926
37	MP0003646_muscle_fatigue	1.33614787
38	MP0003786_premature_aging	1.33300414
39	MP0002736_abnormal_nociception_after	1.31705149
40	MP0001764_abnormal_homeostasis	1.31170361
41	MP0002909_abnormal_adrenal_gland	1.28878491
42	MP0003011_delayed_dark_adaptation	1.26500808
43	MP0001905_abnormal_dopamine_level	1.23876686
44	MP0003045_fibrosis	1.22519546
45	MP0000013_abnormal_adipose_tissue	1.21192483
46	MP0006036_abnormal_mitochondrial_physio	1.20547744
47	MP0009333_abnormal_splenocyte_physiolog	1.20398375
48	MP0004142_abnormal_muscle_tone	1.19230843
49	MP0009046_muscle_twitch	1.18825951
50	MP0005394_taste/olfaction_phenotype	1.18339424
51	MP0005499_abnormal_olfactory_system	1.18339424
52	MP0001968_abnormal_touch/_nociception	1.17315953
53	MP0005646_abnormal_pituitary_gland	1.17222578
54	MP0009745_abnormal_behavioral_response	1.16770530
55	MP0008057_abnormal_DNA_replication	1.15714636
56	MP0003122_maternal_imprinting	1.14230074
57	MP0003763_abnormal_thymus_physiology	1.14025256
58	MP0005253_abnormal_eye_physiology	1.12311787
59	MP0002751_abnormal_autonomic_nervous	1.12290101
60	MP0003693_abnormal_embryo_hatching	1.12163661
61	MP0001800_abnormal_humoral_immune	1.11512033
62	MP0002876_abnormal_thyroid_physiology	1.10760478
63	MP0002928_abnormal_bile_duct	1.10258387
64	MP0005332_abnormal_amino_acid	1.07864294
65	MP0004145_abnormal_muscle_electrophysio	1.07344472
66	MP0000647_abnormal_sebaceous_gland	1.00586573
67	MP0006035_abnormal_mitochondrial_morpho	0.99603836
68	MP0010094_abnormal_chromosome_stability	0.96419209
69	MP0002557_abnormal_social/conspecific_i	0.95734806
70	MP0002272_abnormal_nervous_system	0.92865506
71	MP0001944_abnormal_pancreas_morphology	0.90290022
72	MP0000015_abnormal_ear_pigmentation	0.88411139
73	MP0004742_abnormal_vestibular_system	0.86942668
74	MP0002138_abnormal_hepatobiliary_system	0.86811739
75	MP0005389_reproductive_system_phenotype	0.86811631
76	MP0003121_genomic_imprinting	0.86297060
77	MP0005448_abnormal_energy_balance	0.83335639
78	MP0008007_abnormal_cellular_replicative	0.82331230
79	MP0000631_abnormal_neuroendocrine_gland	0.80384575
80	MP0000685_abnormal_immune_system	0.79991455
81	MP0004043_abnormal_pH_regulation	0.79492434
82	MP0003866_abnormal_defecation	0.77820188
83	MP0001324_abnormal_eye_pigmentation	0.76374235
84	MP0003252_abnormal_bile_duct	0.75648963
85	MP0004133_heterotaxia	0.75266627
86	MP0002733_abnormal_thermal_nociception	0.75204751
87	MP0002234_abnormal_pharynx_morphology	0.74986936
88	MP0001919_abnormal_reproductive_system	0.74933498
89	MP0010329_abnormal_lipoprotein_level	0.74793706
90	MP0004381_abnormal_hair_follicle	0.74656865
91	MP0002078_abnormal_glucose_homeostasis	0.74453856
92	MP0001486_abnormal_startle_reflex	0.73989607
93	MP0001970_abnormal_pain_threshold	0.73959984
94	MP0005636_abnormal_mineral_homeostasis	0.73824026
95	MP0002572_abnormal_emotion/affect_behav	0.72733391
96	MP0001529_abnormal_vocalization	0.72083244
97	MP0005085_abnormal_gallbladder_physiolo	0.70484769
98	MP0002210_abnormal_sex_determination	0.70197858
99	MP0002148_abnormal_hypersensitivity_rea	0.68337835
100	MP0005195_abnormal_posterior_eye	0.68275307

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.36409931
2	Acute necrotizing encephalopathy (HP:0006965)	3.98564719
3	True hermaphroditism (HP:0010459)	3.93908130
4	Pancreatic cysts (HP:0001737)	3.69146567
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.48025635
6	Mitochondrial inheritance (HP:0001427)	3.45981030
7	Acute encephalopathy (HP:0006846)	3.34259875
8	Progressive macrocephaly (HP:0004481)	3.32311408
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.23441449
10	Absent/shortened dynein arms (HP:0200106)	3.23441449
11	Increased CSF lactate (HP:0002490)	3.18602773
12	Abnormal respiratory motile cilium morphology (HP:0005938)	3.17880339
13	Abnormal respiratory epithelium morphology (HP:0012253)	3.17880339
14	Elevated erythrocyte sedimentation rate (HP:0003565)	3.03072077
15	Increased hepatocellular lipid droplets (HP:0006565)	3.02498354
16	Abnormal ciliary motility (HP:0012262)	2.97464687
17	Supernumerary spleens (HP:0009799)	2.93115890
18	Renal Fanconi syndrome (HP:0001994)	2.87792790
19	Cerebral edema (HP:0002181)	2.85249609
20	Abnormality of midbrain morphology (HP:0002418)	2.81973648
21	Molar tooth sign on MRI (HP:0002419)	2.81973648
22	Hypoalbuminemia (HP:0003073)	2.76806419
23	Abnormal albumin level (HP:0012116)	2.76806419
24	Hypoproteinemia (HP:0003075)	2.76333750
25	Lipid accumulation in hepatocytes (HP:0006561)	2.76317828
26	Intestinal atresia (HP:0011100)	2.74414421
27	Chronic sinusitis (HP:0011109)	2.68372021
28	Hypoplasia of the pons (HP:0012110)	2.67405829
29	Abnormality of the renal cortex (HP:0011035)	2.64190107
30	T lymphocytopenia (HP:0005403)	2.61104881
31	Optic disc pallor (HP:0000543)	2.60286522
32	Medial flaring of the eyebrow (HP:0010747)	2.59929267
33	IgG deficiency (HP:0004315)	2.58627830
34	Type II lissencephaly (HP:0007260)	2.56535122
35	Aplastic anemia (HP:0001915)	2.55237498
36	Constricted visual fields (HP:0001133)	2.53265372
37	Nephronophthisis (HP:0000090)	2.52943136
38	Renal cortical cysts (HP:0000803)	2.49669040
39	Abnormality of the pons (HP:0007361)	2.46887507
40	Abnormal hair whorl (HP:0010721)	2.45853869
41	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.40812546
42	Hepatocellular necrosis (HP:0001404)	2.40373337
43	Type 2 muscle fiber atrophy (HP:0003554)	2.39363808
44	3-Methylglutaconic aciduria (HP:0003535)	2.39011729
45	Male pseudohermaphroditism (HP:0000037)	2.34157660
46	Abnormal respiratory motile cilium physiology (HP:0012261)	2.33602648
47	Progressive inability to walk (HP:0002505)	2.32054040
48	Tubular atrophy (HP:0000092)	2.29184196
49	Abnormality of T cell number (HP:0011839)	2.26897761
50	Anencephaly (HP:0002323)	2.24993972
51	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.22374850
52	Abnormality of the renal medulla (HP:0100957)	2.19805779
53	Hepatic necrosis (HP:0002605)	2.19703019
54	Abnormality of renal resorption (HP:0011038)	2.17109133
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.16840656
56	Congenital malformation of the right heart (HP:0011723)	2.16032803
57	Double outlet right ventricle (HP:0001719)	2.16032803
58	Hypomagnesemia (HP:0002917)	2.15492814
59	Thyroiditis (HP:0100646)	2.10745011
60	Cystic liver disease (HP:0006706)	2.10599455
61	Congenital primary aphakia (HP:0007707)	2.09804476
62	Glycosuria (HP:0003076)	2.08412373
63	Abnormality of urine glucose concentration (HP:0011016)	2.08412373
64	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.08227674
65	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.07972059
66	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.07972059
67	Abnormal spermatogenesis (HP:0008669)	2.06504824
68	Increased intramyocellular lipid droplets (HP:0012240)	2.05466160
69	Azoospermia (HP:0000027)	2.04447072
70	Severe combined immunodeficiency (HP:0004430)	2.04230785
71	Optic nerve hypoplasia (HP:0000609)	2.03768119
72	Cerebellar dysplasia (HP:0007033)	2.03281962
73	Poor head control (HP:0002421)	2.03140108
74	Gait imbalance (HP:0002141)	2.02277452
75	Respiratory difficulties (HP:0002880)	2.01001252
76	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.99263855
77	Sclerocornea (HP:0000647)	1.97408173
78	Flat capital femoral epiphysis (HP:0003370)	1.96317859
79	Congenital stationary night blindness (HP:0007642)	1.94577710
80	Hypoplastic iliac wings (HP:0002866)	1.92123332
81	Congenital hepatic fibrosis (HP:0002612)	1.91888455
82	Partial agenesis of the corpus callosum (HP:0001338)	1.89948847
83	Furrowed tongue (HP:0000221)	1.89874625
84	Delayed CNS myelination (HP:0002188)	1.89408875
85	Nephrogenic diabetes insipidus (HP:0009806)	1.85820952
86	Increased serum lactate (HP:0002151)	1.83550773
87	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.83260534
88	Exertional dyspnea (HP:0002875)	1.83074372
89	Polydipsia (HP:0001959)	1.82012761
90	Abnormal drinking behavior (HP:0030082)	1.82012761
91	Large eyes (HP:0001090)	1.81356467
92	Exercise intolerance (HP:0003546)	1.81133246
93	Abolished electroretinogram (ERG) (HP:0000550)	1.80590247
94	Abnormality of T cells (HP:0002843)	1.80151127
95	Anteriorly placed anus (HP:0001545)	1.77814943
96	Leukodystrophy (HP:0002415)	1.76738577
97	Progressive cerebellar ataxia (HP:0002073)	1.75457078
98	Abnormal biliary tract physiology (HP:0012439)	1.75318530
99	Bile duct proliferation (HP:0001408)	1.75318530
100	Methylmalonic acidemia (HP:0002912)	1.75165572

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	3.69866767
2	TXK	3.14131044
3	FRK	3.11476855
4	MAP3K12	2.87997740
5	NEK1	2.65857771
6	TNIK	2.63520089
7	NEK2	2.55839521
8	ADRBK2	2.45615303
9	MKNK2	2.29615533
10	TLK1	2.10217232
11	TAOK3	2.09069961
12	STK16	2.04173587
13	GRK1	1.91745785
14	WNK4	1.85313419
15	WNK3	1.84865368
16	MAP2K7	1.76887845
17	NLK	1.64840314
18	MST4	1.61152399
19	KDR	1.54965392
20	VRK1	1.52771909
21	STK38L	1.50815245
22	ITK	1.45357491
23	MAPK15	1.45005564
24	CDK19	1.44537448
25	ZAK	1.34823761
26	MUSK	1.33413447
27	TEC	1.31024763
28	WEE1	1.30806861
29	EIF2AK3	1.30501641
30	DYRK2	1.24980773
31	MKNK1	1.24494752
32	MAP4K1	1.20006107
33	MAP4K2	1.19329900
34	OXSR1	1.18029901
35	BTK	1.17599176
36	DYRK3	1.14356689
37	MAP2K6	1.10701326
38	NUAK1	1.07173519
39	NME1	1.05145844
40	PNCK	1.04414428
41	BMPR1B	1.02655481
42	VRK2	0.99297615
43	NTRK3	0.98016645
44	STK39	0.93356817
45	PINK1	0.91698872
46	MYLK	0.89017452
47	SCYL2	0.86293339
48	MELK	0.85053836
49	PASK	0.83460047
50	PLK3	0.82078555
51	BCKDK	0.80380114
52	CASK	0.79209617
53	PRKCG	0.78806390
54	PLK1	0.77836495
55	PDK2	0.75542485
56	PRKCQ	0.74434440
57	AURKB	0.73419500
58	TSSK6	0.73360160
59	MAP3K4	0.70127429
60	ERBB3	0.69244487
61	INSRR	0.65524677
62	OBSCN	0.63528305
63	ADRBK1	0.62247639
64	PKN1	0.60745556
65	BLK	0.59894579
66	PTK2B	0.59495478
67	PLK4	0.57711132
68	TNK2	0.57525649
69	ROCK1	0.55693217
70	MAPK13	0.54550207
71	UHMK1	0.53425800
72	ERBB2	0.49867174
73	CSNK1G1	0.49089408
74	SYK	0.48869276
75	CSNK1G3	0.46867728
76	CSNK2A2	0.44985801
77	IRAK1	0.44088587
78	IKBKB	0.43612277
79	CDC7	0.42815946
80	PAK3	0.41348319
81	CSNK2A1	0.38449983
82	STK3	0.38331224
83	FGFR2	0.36662174
84	IKBKE	0.34815344
85	ATR	0.34408206
86	PRKACB	0.34051856
87	PRKACA	0.33927472
88	STK4	0.33501767
89	BMPR2	0.32279240
90	CSNK1A1	0.31926851
91	CHUK	0.31783032
92	LYN	0.31774252
93	PRKG1	0.31649671
94	PRKCA	0.31171671
95	CSNK1G2	0.30574208
96	SRPK1	0.30390884
97	TIE1	0.29829090
98	IGF1R	0.28989026
99	RPS6KA5	0.27421807
100	CAMK2D	0.26713608

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.58719581
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.38008855
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.10730842
4	Parkinsons disease_Homo sapiens_hsa05012	2.86206738
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.67763292
6	RNA polymerase_Homo sapiens_hsa03020	2.53484999
7	Homologous recombination_Homo sapiens_hsa03440	2.49424338
8	Ribosome_Homo sapiens_hsa03010	2.38533151
9	Protein export_Homo sapiens_hsa03060	2.31590080
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.29673045
11	Basal transcription factors_Homo sapiens_hsa03022	2.28144122
12	Asthma_Homo sapiens_hsa05310	1.97133264
13	Huntingtons disease_Homo sapiens_hsa05016	1.96245632
14	Alzheimers disease_Homo sapiens_hsa05010	1.93265527
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.88055830
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.86942821
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.67464063
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.66096594
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.65645092
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.55295363
21	Allograft rejection_Homo sapiens_hsa05330	1.54899024
22	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.54733205
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.53467905
24	Phototransduction_Homo sapiens_hsa04744	1.50002165
25	Butanoate metabolism_Homo sapiens_hsa00650	1.46657135
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.46193186
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.42092753
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.40652463
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.27846157
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.24548317
31	Caffeine metabolism_Homo sapiens_hsa00232	1.23403787
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22979257
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.22715280
34	One carbon pool by folate_Homo sapiens_hsa00670	1.20136670
35	Peroxisome_Homo sapiens_hsa04146	1.15065728
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.09144774
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05698636
38	Base excision repair_Homo sapiens_hsa03410	1.04888039
39	RNA degradation_Homo sapiens_hsa03018	1.03226532
40	Folate biosynthesis_Homo sapiens_hsa00790	1.02452223
41	Propanoate metabolism_Homo sapiens_hsa00640	1.01013569
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.00643593
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00477373
44	Non-homologous end-joining_Homo sapiens_hsa03450	0.99962528
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98857900
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95538043
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.94151451
48	Sulfur metabolism_Homo sapiens_hsa00920	0.93833588
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.91628483
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.90919755
51	Retinol metabolism_Homo sapiens_hsa00830	0.89458953
52	Purine metabolism_Homo sapiens_hsa00230	0.87172577
53	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.85893467
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.85468161
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85381793
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.82204645
57	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.79422063
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.74991353
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.73690733
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72639002
61	Rheumatoid arthritis_Homo sapiens_hsa05323	0.72346879
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70723549
63	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.68552659
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66437218
65	Sulfur relay system_Homo sapiens_hsa04122	0.65931119
66	Regulation of autophagy_Homo sapiens_hsa04140	0.64426601
67	Olfactory transduction_Homo sapiens_hsa04740	0.64217145
68	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.63236199
69	DNA replication_Homo sapiens_hsa03030	0.61971839
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57053991
71	RNA transport_Homo sapiens_hsa03013	0.55651084
72	Metabolic pathways_Homo sapiens_hsa01100	0.54377876
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.54067895
74	Glutathione metabolism_Homo sapiens_hsa00480	0.52514714
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51447915
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49826707
77	Mismatch repair_Homo sapiens_hsa03430	0.49772948
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48105512
79	Herpes simplex infection_Homo sapiens_hsa05168	0.47956912
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47622938
81	Tryptophan metabolism_Homo sapiens_hsa00380	0.46610430
82	Fatty acid degradation_Homo sapiens_hsa00071	0.45278573
83	Arginine biosynthesis_Homo sapiens_hsa00220	0.45129894
84	Insulin secretion_Homo sapiens_hsa04911	0.44613807
85	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.44382029
86	Spliceosome_Homo sapiens_hsa03040	0.43664064
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.43382409
88	Oocyte meiosis_Homo sapiens_hsa04114	0.43250688
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.37907982
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37450844
91	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.37398435
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37223175
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.36946402
94	Taste transduction_Homo sapiens_hsa04742	0.36837961
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.31789280
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.29935444
97	Renin secretion_Homo sapiens_hsa04924	0.29172737
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.28878490
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.28498919
100	p53 signaling pathway_Homo sapiens_hsa04115	0.27064769

PA2G4P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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