PABPC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.21220861
2nuclear pore organization (GO:0006999)4.97313449
3mitotic sister chromatid cohesion (GO:0007064)4.61475123
4DNA unwinding involved in DNA replication (GO:0006268)4.51675681
5protein localization to kinetochore (GO:0034501)4.20616126
6DNA topological change (GO:0006265)4.20166368
7heterochromatin organization (GO:0070828)4.14131018
8mitotic nuclear envelope disassembly (GO:0007077)4.04120582
9pore complex assembly (GO:0046931)4.03059185
10protein localization to chromosome, centromeric region (GO:0071459)3.91209192
11regulation of histone H3-K27 methylation (GO:0061085)3.78808872
12nuclear envelope disassembly (GO:0051081)3.77061599
13membrane disassembly (GO:0030397)3.77061599
14formation of translation preinitiation complex (GO:0001731)3.73015296
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.45474780
16nucleosome disassembly (GO:0006337)3.44953766
17protein-DNA complex disassembly (GO:0032986)3.44953766
18viral transcription (GO:0019083)3.44894058
19regulation of histone H3-K9 methylation (GO:0051570)3.44857391
20translational termination (GO:0006415)3.41462659
21folic acid-containing compound biosynthetic process (GO:0009396)3.40126531
22sister chromatid segregation (GO:0000819)3.39453232
23pre-miRNA processing (GO:0031054)3.37672605
24histone H3-K36 demethylation (GO:0070544)3.36942497
25regulation of RNA export from nucleus (GO:0046831)3.36409582
26regulation of translational fidelity (GO:0006450)3.35421699
27mitotic sister chromatid segregation (GO:0000070)3.31540976
28maturation of SSU-rRNA (GO:0030490)3.31258598
293-UTR-mediated mRNA stabilization (GO:0070935)3.31033600
30establishment of integrated proviral latency (GO:0075713)3.29056454
31DNA duplex unwinding (GO:0032508)3.28072928
32ribosomal small subunit assembly (GO:0000028)3.27849514
33DNA geometric change (GO:0032392)3.25875793
34positive regulation of chromosome segregation (GO:0051984)3.22625891
35mitotic chromosome condensation (GO:0007076)3.21861079
36IMP biosynthetic process (GO:0006188)3.21037401
37DNA replication initiation (GO:0006270)3.19724417
38regulation of DNA endoreduplication (GO:0032875)3.19485057
39negative regulation of histone methylation (GO:0031061)3.17228817
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.15742644
41* RNA stabilization (GO:0043489)3.14544238
42* mRNA stabilization (GO:0048255)3.14544238
43protein export from nucleus (GO:0006611)3.11314583
44DNA strand elongation involved in DNA replication (GO:0006271)3.10509633
45* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09976016
46regulation of spindle organization (GO:0090224)3.08518064
47* translational initiation (GO:0006413)3.08224713
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.07993891
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.07993891
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.07993891
51translational elongation (GO:0006414)3.06461444
52negative regulation of erythrocyte differentiation (GO:0045647)3.05946951
53chromatin assembly (GO:0031497)3.05868129
54negative regulation of RNA splicing (GO:0033119)3.03645124
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02823672
56mitotic metaphase plate congression (GO:0007080)3.00697900
57nuclear envelope organization (GO:0006998)2.98997394
58negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98679336
59protein localization to chromosome (GO:0034502)2.98569937
60IMP metabolic process (GO:0046040)2.97807399
61embryonic process involved in female pregnancy (GO:0060136)2.95713250
62kinetochore organization (GO:0051383)2.94973502
63DNA strand elongation (GO:0022616)2.94661599
64translesion synthesis (GO:0019985)2.93877986
65glucocorticoid receptor signaling pathway (GO:0042921)2.92257591
66dosage compensation (GO:0007549)2.91947110
67regulation of sister chromatid cohesion (GO:0007063)2.91449884
68DNA replication-dependent nucleosome assembly (GO:0006335)2.90117331
69DNA replication-dependent nucleosome organization (GO:0034723)2.90117331
70alternative mRNA splicing, via spliceosome (GO:0000380)2.86717206
71trophectodermal cell differentiation (GO:0001829)2.83836587
72regulation of mitotic spindle organization (GO:0060236)2.83367154
73DNA conformation change (GO:0071103)2.81444458
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.77793425
75protein complex localization (GO:0031503)2.76952223
76chromosome condensation (GO:0030261)2.76387513
77negative regulation of DNA repair (GO:0045738)2.75632338
78monoubiquitinated protein deubiquitination (GO:0035520)2.75393688
79* gene silencing by RNA (GO:0031047)2.74935675
80metaphase plate congression (GO:0051310)2.73958580
81regulation of chromatin binding (GO:0035561)2.73478186
82cytoplasmic mRNA processing body assembly (GO:0033962)2.72424137
83regulation of histone methylation (GO:0031060)2.71395424
84regulation of histone H3-K4 methylation (GO:0051569)2.70962658
85regulation of translational termination (GO:0006449)2.70092084
86cellular protein complex disassembly (GO:0043624)2.69804783
87regulation of transcription from RNA polymerase I promoter (GO:0006356)2.67716087
88negative regulation of mRNA processing (GO:0050686)2.65518242
89* regulation of mRNA stability (GO:0043488)2.65088784
90protein complex disassembly (GO:0043241)2.64807459
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64441641
92meiotic chromosome segregation (GO:0045132)2.64186207
93chaperone-mediated protein complex assembly (GO:0051131)2.64084183
94viral life cycle (GO:0019058)2.62158733
95chromatin assembly or disassembly (GO:0006333)2.61957590
96histone H2B ubiquitination (GO:0033523)2.61314272
97protein localization to microtubule (GO:0035372)2.61067926
98NLS-bearing protein import into nucleus (GO:0006607)2.60651501
99cellular protein complex localization (GO:0034629)2.60488150
100regulation of chromosome segregation (GO:0051983)2.59885180
101regulation of stem cell maintenance (GO:2000036)2.59062035
102ribonucleoprotein complex biogenesis (GO:0022613)2.58674496
103telomere maintenance via semi-conservative replication (GO:0032201)2.57656596
104definitive hemopoiesis (GO:0060216)2.57296544
105positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57058405
106protein targeting to ER (GO:0045047)2.57028973
107ribosomal large subunit biogenesis (GO:0042273)2.55889167
108regulation of centriole replication (GO:0046599)2.55694126
109ribosomal small subunit biogenesis (GO:0042274)2.55487082
110regulation of translational initiation (GO:0006446)2.55114549
111DNA packaging (GO:0006323)2.55021804
112sister chromatid cohesion (GO:0007062)2.54611112
113attachment of spindle microtubules to kinetochore (GO:0008608)2.54406015
114cotranslational protein targeting to membrane (GO:0006613)2.54244518
115regulation of nucleobase-containing compound transport (GO:0032239)2.54071367
116DNA replication checkpoint (GO:0000076)2.53467865
117ribosome assembly (GO:0042255)2.52021002
118regulation of NFAT protein import into nucleus (GO:0051532)2.51990323
119establishment of chromosome localization (GO:0051303)2.51337642
120mitotic recombination (GO:0006312)2.50799320
121* gene silencing (GO:0016458)2.50622032
122ribosome biogenesis (GO:0042254)2.50543606
123nucleobase biosynthetic process (GO:0046112)2.50375492
124mRNA transport (GO:0051028)2.50216059
125regulation of centrosome cycle (GO:0046605)2.49786924
126histone H2A monoubiquitination (GO:0035518)2.49711150
127cellular response to epidermal growth factor stimulus (GO:0071364)2.49289029
128pentose-phosphate shunt (GO:0006098)2.49039054
129* nuclear-transcribed mRNA catabolic process (GO:0000956)2.48979000
130* negative regulation of mRNA metabolic process (GO:1903312)2.48748186
131histone H3-K9 demethylation (GO:0033169)2.48657114
132* regulation of RNA stability (GO:0043487)2.48483171
133* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.46232220
134* mRNA splicing, via spliceosome (GO:0000398)2.46232220
135Golgi transport vesicle coating (GO:0048200)2.46191656
136COPI coating of Golgi vesicle (GO:0048205)2.46191656
137cellular response to virus (GO:0098586)2.45869544
138histone lysine demethylation (GO:0070076)2.43471877
139V(D)J recombination (GO:0033151)2.43221043
140DNA synthesis involved in DNA repair (GO:0000731)2.41790444
141* RNA splicing, via transesterification reactions (GO:0000375)2.41026833
142corticosteroid receptor signaling pathway (GO:0031958)2.39845357
143positive regulation of gene expression, epigenetic (GO:0045815)2.33685347
144RNA export from nucleus (GO:0006405)2.33597421
145histone demethylation (GO:0016577)2.33349209
146planar cell polarity pathway involved in neural tube closure (GO:0090179)2.31588817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.76250505
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.90512586
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.62023943
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.39140743
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.37034530
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18365512
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.07514656
8* MYC_22102868_ChIP-Seq_BL_Human3.02634686
9* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.73437370
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57455472
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33722938
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23921301
13AR_21909140_ChIP-Seq_LNCAP_Human2.23130900
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09938648
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.04901035
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91904721
17* XRN2_22483619_ChIP-Seq_HELA_Human1.86383086
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82423380
19ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81690106
20* VDR_21846776_ChIP-Seq_THP-1_Human1.78820748
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75087513
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71796369
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71796369
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71796369
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62734160
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61201100
27CIITA_25753668_ChIP-Seq_RAJI_Human1.58162638
28CLOCK_20551151_ChIP-Seq_293T_Human1.57819598
29* TCF7_22412390_ChIP-Seq_EML_Mouse1.54937847
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54432431
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49270552
32SCL_19346495_ChIP-Seq_HPC-7_Human1.46544422
33KDM5A_27292631_Chip-Seq_BREAST_Human1.44893086
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44508453
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.43499767
36RACK7_27058665_Chip-Seq_MCF-7_Human1.39742923
37* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39602194
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.38224907
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.37614843
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37448509
41* VDR_23849224_ChIP-Seq_CD4+_Human1.37371594
42MAF_26560356_Chip-Seq_TH1_Human1.36612248
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.35757516
44UTX_26944678_Chip-Seq_JUKART_Human1.34850459
45* TTF2_22483619_ChIP-Seq_HELA_Human1.32914907
46TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32641357
47FOXP3_21729870_ChIP-Seq_TREG_Human1.32412099
48MYB_26560356_Chip-Seq_TH2_Human1.31324325
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30073172
50MYB_26560356_Chip-Seq_TH1_Human1.29651092
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29039814
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28882611
53* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27688365
54* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27431837
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26854770
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26688811
57* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26432784
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26251146
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26176680
60TFEB_21752829_ChIP-Seq_HELA_Human1.25407725
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25275359
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25274165
63DCP1A_22483619_ChIP-Seq_HELA_Human1.23484684
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23321665
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22569900
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22307655
67* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19983481
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19911934
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19614791
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18996065
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18381771
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17947968
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16691043
74GABP_19822575_ChIP-Seq_HepG2_Human1.16319481
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16104928
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15100369
77* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14586636
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14486007
79ELK1_19687146_ChIP-ChIP_HELA_Human1.12894891
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11096410
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10832356
82* SPI1_23547873_ChIP-Seq_NB4_Human1.10149144
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.09987019
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.09624168
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.09557927
86* KDM2B_26808549_Chip-Seq_DND41_Human1.07660288
87NCOR1_26117541_ChIP-Seq_K562_Human1.07432538
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07171149
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06574005
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05164466
91* VDR_24763502_ChIP-Seq_THP-1_Human1.04577406
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04391549
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03910264
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03788804
95ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02656469
96E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02313031
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01617469
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01149820
99* CHD1_26751641_Chip-Seq_LNCaP_Human1.00370519
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97643036
101HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97141538
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96174426
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95987458
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95916181
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95868265
106MAF_26560356_Chip-Seq_TH2_Human0.95774034
107* ATF3_27146783_Chip-Seq_COLON_Human0.95239839
108* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95110350
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94637499
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94377255
111* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94292016
112GABP_17652178_ChIP-ChIP_JURKAT_Human0.91554822
113* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91078943
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90683674
115ZNF263_19887448_ChIP-Seq_K562_Human0.90207815
116NANOG_21062744_ChIP-ChIP_HESCs_Human0.88579926
117* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88436239
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88379984
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85983154
120PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85706551
121SALL1_21062744_ChIP-ChIP_HESCs_Human0.85433792
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85293760
123* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84064515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.31618756
2MP0010352_gastrointestinal_tract_polyps3.29807597
3MP0003111_abnormal_nucleus_morphology3.13703328
4MP0010094_abnormal_chromosome_stability3.13065235
5MP0004957_abnormal_blastocyst_morpholog3.02382775
6MP0008057_abnormal_DNA_replication2.85959332
7MP0003077_abnormal_cell_cycle2.81710133
8MP0002396_abnormal_hematopoietic_system2.67676573
9MP0002009_preneoplasia2.48756436
10MP0005076_abnormal_cell_differentiation2.45161034
11MP0002796_impaired_skin_barrier2.34213866
12MP0004808_abnormal_hematopoietic_stem2.27541993
13MP0003705_abnormal_hypodermis_morpholog2.16443413
14MP0010307_abnormal_tumor_latency2.15570714
15MP0001730_embryonic_growth_arrest2.08937885
16MP0008007_abnormal_cellular_replicative2.06810922
17MP0008877_abnormal_DNA_methylation1.97071448
18MP0000350_abnormal_cell_proliferation1.96243265
19MP0009278_abnormal_bone_marrow1.84266240
20MP0008058_abnormal_DNA_repair1.80036312
21MP0005397_hematopoietic_system_phenotyp1.78747528
22MP0001545_abnormal_hematopoietic_system1.78747528
23MP0004197_abnormal_fetal_growth/weight/1.72999660
24MP0000490_abnormal_crypts_of1.67307743
25MP0003300_gastrointestinal_ulcer1.63062166
26MP0001672_abnormal_embryogenesis/_devel1.62749782
27MP0005380_embryogenesis_phenotype1.62749782
28MP0005451_abnormal_body_composition1.60115442
29MP0003984_embryonic_growth_retardation1.59102932
30MP0001697_abnormal_embryo_size1.58916184
31MP0002086_abnormal_extraembryonic_tissu1.58871453
32MP0002088_abnormal_embryonic_growth/wei1.56580062
33MP0002084_abnormal_developmental_patter1.53122354
34MP0003566_abnormal_cell_adhesion1.52834171
35MP0008932_abnormal_embryonic_tissue1.48989630
36MP0002877_abnormal_melanocyte_morpholog1.45486065
37MP0001873_stomach_inflammation1.43295803
38MP0002080_prenatal_lethality1.42473194
39MP0003123_paternal_imprinting1.38891915
40MP0002085_abnormal_embryonic_tissue1.37431680
41MP0002398_abnormal_bone_marrow1.36166086
42MP0000703_abnormal_thymus_morphology1.34928335
43MP0000537_abnormal_urethra_morphology1.34250857
44MP0003763_abnormal_thymus_physiology1.32973246
45MP0006054_spinal_hemorrhage1.32474927
46MP0005023_abnormal_wound_healing1.32242781
47MP0002019_abnormal_tumor_incidence1.32189062
48MP0000313_abnormal_cell_death1.24769024
49MP0005410_abnormal_fertilization1.23420103
50MP0005666_abnormal_adipose_tissue1.22918864
51MP0003567_abnormal_fetal_cardiomyocyte1.22345026
52MP0003303_peritoneal_inflammation1.21647332
53MP0009333_abnormal_splenocyte_physiolog1.21156762
54MP0005623_abnormal_meninges_morphology1.21156713
55MP0004233_abnormal_muscle_weight1.20632576
56MP0005409_darkened_coat_color1.20550949
57MP0000733_abnormal_muscle_development1.18861565
58MP0002722_abnormal_immune_system1.18624315
59MP0000858_altered_metastatic_potential1.16814189
60MP0001915_intracranial_hemorrhage1.16104342
61MP0009053_abnormal_anal_canal1.16038372
62MP0000678_abnormal_parathyroid_gland1.13088792
63MP0000685_abnormal_immune_system1.09000783
64MP0000689_abnormal_spleen_morphology1.08477106
65MP0003786_premature_aging1.08018207
66MP0002060_abnormal_skin_morphology1.06916232
67MP0010234_abnormal_vibrissa_follicle1.05910808
68MP0001929_abnormal_gametogenesis1.05047880
69MP0002210_abnormal_sex_determination1.04315628
70MP0001293_anophthalmia1.04226036
71MP0008260_abnormal_autophagy1.03158512
72MP0009379_abnormal_foot_pigmentation1.01325781
73MP0001849_ear_inflammation1.00762043
74MP0002405_respiratory_system_inflammati0.99908930
75MP0002166_altered_tumor_susceptibility0.98838009
76MP0002429_abnormal_blood_cell0.97282260
77MP0000627_abnormal_mammary_gland0.96490930
78MP0000377_abnormal_hair_follicle0.96144032
79MP0009931_abnormal_skin_appearance0.96107200
80MP0001145_abnormal_male_reproductive0.95938195
81MP0001800_abnormal_humoral_immune0.95116720
82MP0009672_abnormal_birth_weight0.93270895
83MP0003943_abnormal_hepatobiliary_system0.92643876
84MP0000716_abnormal_immune_system0.92558858
85MP0010678_abnormal_skin_adnexa0.92300347
86MP0003436_decreased_susceptibility_to0.91540376
87MP0001881_abnormal_mammary_gland0.90922435
88MP0004264_abnormal_extraembryonic_tissu0.90401295
89MP0010630_abnormal_cardiac_muscle0.90085805
90MP0003448_altered_tumor_morphology0.89183008
91MP0000465_gastrointestinal_hemorrhage0.88575905
92MP0002925_abnormal_cardiovascular_devel0.88354185
93MP0004381_abnormal_hair_follicle0.87777305
94MP0003115_abnormal_respiratory_system0.87004021
95MP0004947_skin_inflammation0.86788166
96MP0002006_tumorigenesis0.86097986
97MP0010155_abnormal_intestine_physiology0.85881260
98MP0004782_abnormal_surfactant_physiolog0.85818319
99MP0009703_decreased_birth_body0.85792808
100MP0001348_abnormal_lacrimal_gland0.84808166
101MP0002452_abnormal_antigen_presenting0.84667075
102MP0002420_abnormal_adaptive_immunity0.82008173
103MP0000477_abnormal_intestine_morphology0.81991210
104MP0002092_abnormal_eye_morphology0.80831011
105MP0001819_abnormal_immune_cell0.80646048
106MP0002089_abnormal_postnatal_growth/wei0.79409516
107MP0005621_abnormal_cell_physiology0.78891255
108MP0005501_abnormal_skin_physiology0.78537770
109MP0003121_genomic_imprinting0.78444241
110MP0003221_abnormal_cardiomyocyte_apopto0.78396338
111MP0002098_abnormal_vibrissa_morphology0.78385346
112MP0003890_abnormal_embryonic-extraembry0.78180586
113MP0001853_heart_inflammation0.77764938
114MP0004858_abnormal_nervous_system0.77147631
115MP0000428_abnormal_craniofacial_morphol0.76812968
116MP0003315_abnormal_perineum_morphology0.76531466
117MP0003941_abnormal_skin_development0.76462001
118MP0000653_abnormal_sex_gland0.76363536
119MP0010030_abnormal_orbit_morphology0.76093190
120MP0009697_abnormal_copulation0.74198766
121MP0008770_decreased_survivor_rate0.73007089
122MP0005464_abnormal_platelet_physiology0.71543326
123MP0002697_abnormal_eye_size0.71437372
124MP0004185_abnormal_adipocyte_glucose0.71180361
125MP0001216_abnormal_epidermal_layer0.70924732
126MP0002723_abnormal_immune_serum0.70597261
127MP0003453_abnormal_keratinocyte_physiol0.70248324
128MP0003091_abnormal_cell_migration0.69688442
129MP0005384_cellular_phenotype0.68905902
130MP0001851_eye_inflammation0.67592749

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.30333212
2Deviation of the thumb (HP:0009603)3.12162660
3Proximal placement of thumb (HP:0009623)3.09089863
4Selective tooth agenesis (HP:0001592)2.94907203
5Increased nuchal translucency (HP:0010880)2.93433102
6Ankyloglossia (HP:0010296)2.85586720
7Reticulocytopenia (HP:0001896)2.80816556
8Increased density of long bones (HP:0006392)2.78629371
9Ectopic kidney (HP:0000086)2.75278682
10Abnormality of the fingertips (HP:0001211)2.74585244
11Asymmetry of the thorax (HP:0001555)2.73161801
12Nasal polyposis (HP:0100582)2.57444127
13Basal cell carcinoma (HP:0002671)2.54233137
14Rectal prolapse (HP:0002035)2.53287363
15Thrombocytosis (HP:0001894)2.53210695
16Ependymoma (HP:0002888)2.52648165
17Flat acetabular roof (HP:0003180)2.52513618
18Abnormality of cells of the erythroid lineage (HP:0012130)2.48938378
19Abnormality of oral frenula (HP:0000190)2.44687895
20Long palpebral fissure (HP:0000637)2.43010124
21Disproportionate tall stature (HP:0001519)2.40930366
22Colon cancer (HP:0003003)2.40457307
23Abnormal number of erythroid precursors (HP:0012131)2.35688378
24High pitched voice (HP:0001620)2.34928316
25Long eyelashes (HP:0000527)2.34921390
26Prominent nose (HP:0000448)2.30270514
27Deep palmar crease (HP:0006191)2.26830471
28Acute myeloid leukemia (HP:0004808)2.26812270
29Abnormality of the thoracic spine (HP:0100711)2.26700443
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.24058846
31Short 4th metacarpal (HP:0010044)2.24058846
32Degeneration of anterior horn cells (HP:0002398)2.23576819
33Abnormality of the anterior horn cell (HP:0006802)2.23576819
34Medulloblastoma (HP:0002885)2.20839648
35Hyperacusis (HP:0010780)2.20578928
36Insidious onset (HP:0003587)2.18132208
37Termporal pattern (HP:0011008)2.18132208
38Multiple enchondromatosis (HP:0005701)2.17956404
39Myelodysplasia (HP:0002863)2.16571231
40Spinal cord lesions (HP:0100561)2.14278938
41Syringomyelia (HP:0003396)2.14278938
42Nephroblastoma (Wilms tumor) (HP:0002667)2.14225879
43Acute lymphatic leukemia (HP:0006721)2.11931891
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11451649
45Progressive external ophthalmoplegia (HP:0000590)2.11263278
46Overlapping toe (HP:0001845)2.10939220
47Abnormality of the nasal mucosa (HP:0000433)2.09870712
4811 pairs of ribs (HP:0000878)2.09555851
49Chromsome breakage (HP:0040012)2.08108757
50Squamous cell carcinoma (HP:0002860)2.06444648
51Heterotopia (HP:0002282)2.05189186
52Blepharitis (HP:0000498)2.04871484
53Metaphyseal cupping (HP:0003021)2.03638371
54Thoracic kyphosis (HP:0002942)2.01977870
55Broad face (HP:0000283)2.01299023
56Abnormality of chromosome stability (HP:0003220)1.99620451
57Impulsivity (HP:0100710)1.97953057
58Recurrent bronchitis (HP:0002837)1.97594728
59Missing ribs (HP:0000921)1.96272087
60Biliary tract neoplasm (HP:0100574)1.95576313
61Atresia of the external auditory canal (HP:0000413)1.95091966
62Dysmetric saccades (HP:0000641)1.94203489
63Cutaneous melanoma (HP:0012056)1.94007766
64Seborrheic dermatitis (HP:0001051)1.93917624
65Abnormality of the distal phalanx of the thumb (HP:0009617)1.93358025
66Embryonal renal neoplasm (HP:0011794)1.91443317
67Malignant gastrointestinal tract tumors (HP:0006749)1.90994750
68Gastrointestinal carcinoma (HP:0002672)1.90994750
69Cutis marmorata (HP:0000965)1.89426336
70Progressive muscle weakness (HP:0003323)1.88049081
71Birth length less than 3rd percentile (HP:0003561)1.87262257
72Amaurosis fugax (HP:0100576)1.86957439
73Germ cell neoplasia (HP:0100728)1.85856130
74Insomnia (HP:0100785)1.85341670
75Uterine leiomyosarcoma (HP:0002891)1.84380973
76Leiomyosarcoma (HP:0100243)1.84380973
77Broad palm (HP:0001169)1.84373719
78Pseudobulbar signs (HP:0002200)1.84333610
79Pallor (HP:0000980)1.83959257
80Micronodular cirrhosis (HP:0001413)1.83115806
81Urethral obstruction (HP:0000796)1.83098163
82Protrusio acetabuli (HP:0003179)1.83007941
83Agnosia (HP:0010524)1.82972596
84Absent thumb (HP:0009777)1.82855400
85Macroorchidism (HP:0000053)1.82848721
86Obstructive sleep apnea (HP:0002870)1.81981849
87Osteolytic defects of the phalanges of the hand (HP:0009771)1.80988853
88Osteolytic defects of the hand bones (HP:0009699)1.80988853
89Patellar dislocation (HP:0002999)1.80421636
90Astrocytoma (HP:0009592)1.80227229
91Abnormality of the astrocytes (HP:0100707)1.80227229
92Back pain (HP:0003418)1.79814388
93Viral hepatitis (HP:0006562)1.79678795
94Truncal obesity (HP:0001956)1.79545312
95Skin tags (HP:0010609)1.79283362
96High anterior hairline (HP:0009890)1.78337806
97Deep philtrum (HP:0002002)1.77453891
98Neoplasm of the oral cavity (HP:0100649)1.76393968
99Low anterior hairline (HP:0000294)1.75760823
100Trismus (HP:0000211)1.75011439
101Neonatal hypoglycemia (HP:0001998)1.73820967
102Cellulitis (HP:0100658)1.73787534
103IgM deficiency (HP:0002850)1.73318203
104Rhabdomyosarcoma (HP:0002859)1.72682317
105Sparse lateral eyebrow (HP:0005338)1.72298194
106Genu recurvatum (HP:0002816)1.71860690
107Abnormal number of incisors (HP:0011064)1.71122036
108Bicuspid aortic valve (HP:0001647)1.70471740
109Abnormal platelet volume (HP:0011876)1.70080932
110Neoplasm of the pancreas (HP:0002894)1.68927815
111Abnormality of reticulocytes (HP:0004312)1.68860004
112Small intestinal stenosis (HP:0012848)1.66348891
113Duodenal stenosis (HP:0100867)1.66348891
114Abnormality of the salivary glands (HP:0010286)1.66302447
115Aplasia/Hypoplasia of the thymus (HP:0010515)1.65996869
116Transitional cell carcinoma of the bladder (HP:0006740)1.65675057
117Capillary hemangiomas (HP:0005306)1.65327536
118Bowel incontinence (HP:0002607)1.65277717
119Glossoptosis (HP:0000162)1.64622745
120Slow saccadic eye movements (HP:0000514)1.64493037
121Recurrent viral infections (HP:0004429)1.64462955
122Ankle contracture (HP:0006466)1.63146974
123Abnormality of the calcaneus (HP:0008364)1.62783518
124Fatigue (HP:0012378)1.62497124
125Limited elbow extension (HP:0001377)1.62262543
126Absent frontal sinuses (HP:0002688)1.62039361
127Abnormality of the parietal bone (HP:0002696)1.61739925
128Vertebral arch anomaly (HP:0008438)1.61732688
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.61446917
130Microglossia (HP:0000171)1.60912440
131Progressive hearing impairment (HP:0001730)1.60602061
132Supernumerary ribs (HP:0005815)1.60505782
133Cafe-au-lait spot (HP:0000957)1.60388264
134Sandal gap (HP:0001852)1.60343940
135Curly hair (HP:0002212)1.60185165
136Septate vagina (HP:0001153)1.59598941
137Abnormality of the phalanges of the hallux (HP:0010057)1.58541417
138Abnormality of the gastric mucosa (HP:0004295)1.58457828
139Increased mean platelet volume (HP:0011877)1.57948852
140Obsessive-compulsive behavior (HP:0000722)1.57668768
141Flared metaphyses (HP:0003015)1.57469062
142Abnormality of the preputium (HP:0100587)1.56889135
143Preauricular skin tag (HP:0000384)1.56749256
144Macrocytic anemia (HP:0001972)1.56493191
145Patellar aplasia (HP:0006443)1.55974802
146Poikiloderma (HP:0001029)1.55946379
147Abnormality of the peritoneum (HP:0002585)1.55618137
148Arnold-Chiari malformation (HP:0002308)1.55504023
149Renal cell carcinoma (HP:0005584)1.55017843
150Subacute progressive viral hepatitis (HP:0006572)1.54139800
151Reticulocytosis (HP:0001923)1.54126411
152Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.53970960
153Neoplasm of striated muscle (HP:0009728)1.53048417
154Abnormal vertebral ossification (HP:0100569)1.52940526
155Cervical subluxation (HP:0003308)1.52086559
156Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.51653579
157Bronchitis (HP:0012387)1.50776130
158Abnormal large intestine physiology (HP:0012700)1.50673326
159Ulnar bowing (HP:0003031)1.50165552
160Advanced eruption of teeth (HP:0006288)1.49875006
161Lymphoma (HP:0002665)1.49426498
162Gastrointestinal inflammation (HP:0004386)1.49240128
163Abnormality of the 4th metacarpal (HP:0010012)1.48763795
164Premature skin wrinkling (HP:0100678)1.47516982
165Bladder carcinoma (HP:0002862)1.47406067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.27404899
2EEF2K4.02565789
3SMG13.52815334
4CDC73.48765640
5NEK22.87068757
6MAP3K102.46672074
7PKN22.45776112
8PRPF4B2.40408314
9WEE12.29214103
10STK102.20900568
11TRIB32.03771497
12BRD41.93442738
13MAP4K11.90756214
14RPS6KB21.90563911
15RPS6KA41.82272272
16PASK1.74928760
17TAF11.69209896
18CDK41.68237288
19TTK1.63804388
20EPHA21.62329638
21CDK61.59330171
22CDK71.48574713
23SIK31.48341225
24STK31.47886612
25TSSK61.46859315
26LRRK21.46728178
27SCYL21.39162467
28MAP3K81.37390061
29TGFBR11.36462294
30ATR1.34967209
31MKNK11.34664135
32FGFR41.31487888
33ALK1.30304521
34MAP3K131.29892016
35IRAK31.29781276
36MAP3K141.28332553
37BUB11.26288813
38BRSK21.25155605
39ICK1.22320907
40TESK11.22077477
41LATS21.20724602
42MTOR1.20230969
43CHEK11.19677044
44AURKB1.18059754
45PAK41.16465162
46MST1R1.15487111
47PIM11.12290295
48PLK11.09757313
49EIF2AK11.07985310
50PBK1.04811600
51LATS11.04526624
52PTK61.02215562
53NME21.00466800
54JAK30.99932690
55TESK20.99657478
56STK40.99221643
57ERN10.96950622
58DYRK30.95441622
59PAK20.94564704
60RIPK40.94044959
61FLT30.93250819
62VRK20.91987433
63BMX0.91727423
64ATM0.90916310
65MAP2K30.90112471
66NEK10.89020591
67PDK40.87963847
68PDK30.87963847
69MKNK20.86687601
70BTK0.85431873
71CHEK20.85142617
72ACVR1B0.84180861
73ZAP700.81011116
74YES10.80784078
75CDK20.80319810
76TTN0.79743022
77PLK30.77103279
78SRPK10.75667535
79KSR20.73249078
80STK240.69927363
81MAP2K20.67776897
82GRK60.67026709
83PNCK0.66096339
84CHUK0.64751356
85PLK40.63679490
86CDK90.63130851
87MELK0.61124480
88MET0.60792948
89MAP3K90.60555009
90CAMK1D0.60449966
91IRAK40.59143653
92PIM20.58883570
93FGFR10.55580172
94HIPK20.54225636
95MAP3K60.50988803
96CDK10.50504104
97TAOK20.50354898
98RIPK10.48913228
99CSNK2A20.46878057
100PDGFRA0.46800329
101PAK10.46304666
102CAMK1G0.45902747
103TAOK10.45364635
104EPHB10.44646625
105KSR10.43891618
106CSF1R0.43811241
107NEK90.43617715
108DYRK1B0.43607304
109IRAK20.43534681
110TYRO30.42079854
111CSNK1D0.41891147
112MAPKAPK20.41780208
113AURKA0.41457425
114RET0.41127873
115EIF2AK20.40914115
116WNK10.40764114
117DMPK0.40489361
118CLK10.40332132
119FGFR30.39331402
120MAP3K10.38786246
121BRSK10.38427337
122RPS6KC10.37704540
123RPS6KL10.37704540
124CSK0.37305507
125PRKDC0.37059100
126MAPK10.36604648
127CSNK1E0.36254940
128RPS6KA10.35988294
129PTK20.35819675
130MST40.35382857
131PDGFRB0.35304103
132ITK0.34527903
133MAPK140.34397944
134SIK10.33310111

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.51564558
2* RNA transport_Homo sapiens_hsa030132.84539729
3Mismatch repair_Homo sapiens_hsa034302.75629770
4Spliceosome_Homo sapiens_hsa030402.67005587
5Cell cycle_Homo sapiens_hsa041102.60423563
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54807582
7Ribosome_Homo sapiens_hsa030102.28415268
8One carbon pool by folate_Homo sapiens_hsa006702.24238851
9Base excision repair_Homo sapiens_hsa034102.09622536
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08918000
11Homologous recombination_Homo sapiens_hsa034401.96140060
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92875463
13* mRNA surveillance pathway_Homo sapiens_hsa030151.88833051
14Nucleotide excision repair_Homo sapiens_hsa034201.83349529
15Antigen processing and presentation_Homo sapiens_hsa046121.75512083
16p53 signaling pathway_Homo sapiens_hsa041151.66144673
17Fanconi anemia pathway_Homo sapiens_hsa034601.62066214
18Non-homologous end-joining_Homo sapiens_hsa034501.61030298
19Small cell lung cancer_Homo sapiens_hsa052221.57256435
20Chronic myeloid leukemia_Homo sapiens_hsa052201.52376332
21Herpes simplex infection_Homo sapiens_hsa051681.39858189
22* RNA degradation_Homo sapiens_hsa030181.38263708
23Viral carcinogenesis_Homo sapiens_hsa052031.36787001
24MicroRNAs in cancer_Homo sapiens_hsa052061.33597857
25HTLV-I infection_Homo sapiens_hsa051661.31131218
26ErbB signaling pathway_Homo sapiens_hsa040121.24447167
27Epstein-Barr virus infection_Homo sapiens_hsa051691.23879767
28Acute myeloid leukemia_Homo sapiens_hsa052211.20175800
29Thyroid cancer_Homo sapiens_hsa052161.18579797
30Basal transcription factors_Homo sapiens_hsa030221.16611797
31Pyrimidine metabolism_Homo sapiens_hsa002401.14222790
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11756483
33RNA polymerase_Homo sapiens_hsa030201.11543087
34Measles_Homo sapiens_hsa051621.11086883
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10057933
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09661315
37Primary immunodeficiency_Homo sapiens_hsa053401.08403042
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05620967
39B cell receptor signaling pathway_Homo sapiens_hsa046621.04610345
40Hepatitis B_Homo sapiens_hsa051611.04067751
41Adherens junction_Homo sapiens_hsa045201.03782373
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.02799537
43Legionellosis_Homo sapiens_hsa051341.02470388
44Viral myocarditis_Homo sapiens_hsa054161.02435069
45Prolactin signaling pathway_Homo sapiens_hsa049170.99190887
46Hepatitis C_Homo sapiens_hsa051600.97543747
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96047095
48Colorectal cancer_Homo sapiens_hsa052100.96010563
49Apoptosis_Homo sapiens_hsa042100.94935745
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94381160
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93644539
52Shigellosis_Homo sapiens_hsa051310.93488305
53Toxoplasmosis_Homo sapiens_hsa051450.92821109
54Glioma_Homo sapiens_hsa052140.92053208
55Proteoglycans in cancer_Homo sapiens_hsa052050.91109977
56Insulin signaling pathway_Homo sapiens_hsa049100.89602819
57Bladder cancer_Homo sapiens_hsa052190.89383754
58Leishmaniasis_Homo sapiens_hsa051400.88771033
59Choline metabolism in cancer_Homo sapiens_hsa052310.88405231
60Notch signaling pathway_Homo sapiens_hsa043300.87981071
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87540924
62Non-small cell lung cancer_Homo sapiens_hsa052230.87478392
63Pancreatic cancer_Homo sapiens_hsa052120.87016937
64Lysine degradation_Homo sapiens_hsa003100.85266106
65Prostate cancer_Homo sapiens_hsa052150.83337716
66Hematopoietic cell lineage_Homo sapiens_hsa046400.83092676
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.82905717
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.81509996
69Oocyte meiosis_Homo sapiens_hsa041140.80287688
70Inositol phosphate metabolism_Homo sapiens_hsa005620.79825949
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.79757595
72T cell receptor signaling pathway_Homo sapiens_hsa046600.77747026
73Hippo signaling pathway_Homo sapiens_hsa043900.76977852
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76972958
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75104372
76Selenocompound metabolism_Homo sapiens_hsa004500.74623997
77TGF-beta signaling pathway_Homo sapiens_hsa043500.74262251
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73955171
79mTOR signaling pathway_Homo sapiens_hsa041500.73244383
80Basal cell carcinoma_Homo sapiens_hsa052170.73228177
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72877481
82Wnt signaling pathway_Homo sapiens_hsa043100.72785490
83Influenza A_Homo sapiens_hsa051640.72254367
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71159749
85Pathways in cancer_Homo sapiens_hsa052000.70665616
86Osteoclast differentiation_Homo sapiens_hsa043800.69989415
87Biosynthesis of amino acids_Homo sapiens_hsa012300.67532536
88Endometrial cancer_Homo sapiens_hsa052130.66623950
89Focal adhesion_Homo sapiens_hsa045100.65212402
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65209555
91HIF-1 signaling pathway_Homo sapiens_hsa040660.64740743
92Pentose phosphate pathway_Homo sapiens_hsa000300.63591669
93Melanoma_Homo sapiens_hsa052180.61632479
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61499025
95AMPK signaling pathway_Homo sapiens_hsa041520.60780602
96Estrogen signaling pathway_Homo sapiens_hsa049150.60599319
97Proteasome_Homo sapiens_hsa030500.59840091
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59814508
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.59514269
100ECM-receptor interaction_Homo sapiens_hsa045120.59401388
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.59388883
102Platelet activation_Homo sapiens_hsa046110.58751697
103Insulin resistance_Homo sapiens_hsa049310.57499969
104TNF signaling pathway_Homo sapiens_hsa046680.56593519
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.53416317
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53316151
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53223992
108Dorso-ventral axis formation_Homo sapiens_hsa043200.52671155
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51329147
110VEGF signaling pathway_Homo sapiens_hsa043700.51298228
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.49359500
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49080971
113Renal cell carcinoma_Homo sapiens_hsa052110.48237370
114Amoebiasis_Homo sapiens_hsa051460.46232935
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45926367
116Systemic lupus erythematosus_Homo sapiens_hsa053220.45795054
117FoxO signaling pathway_Homo sapiens_hsa040680.45781271
118N-Glycan biosynthesis_Homo sapiens_hsa005100.43200811
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42969089
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42580865
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42329624

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