PABPC1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.90879555
2regulation of female gonad development (GO:2000194)9.40498201
3negative regulation of meiosis (GO:0045835)6.66309136
4regulation of meiosis (GO:0040020)6.48171559
5negative regulation of fibrinolysis (GO:0051918)6.35050219
6DNA methylation involved in gamete generation (GO:0043046)6.12635896
7histone H2A monoubiquitination (GO:0035518)6.03603859
8female gamete generation (GO:0007292)5.84945138
9base-excision repair, AP site formation (GO:0006285)5.72431765
10pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.69060132
11DNA damage induced protein phosphorylation (GO:0006975)5.67568009
12histone H2A ubiquitination (GO:0033522)5.57031552
13negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.45166195
14male meiosis (GO:0007140)5.39075383
15mitotic metaphase plate congression (GO:0007080)5.38330923
16regulation of fibrinolysis (GO:0051917)5.38097367
17mitotic chromosome condensation (GO:0007076)5.30361315
18citrulline biosynthetic process (GO:0019240)5.20334979
19negative regulation of smooth muscle cell differentiation (GO:0051151)5.17301638
20regulation of exit from mitosis (GO:0007096)5.13407351
21mannose metabolic process (GO:0006013)5.04846069
22regulation of meiotic cell cycle (GO:0051445)5.04618155
23meiotic cell cycle (GO:0051321)5.00678234
24pyrimidine nucleotide catabolic process (GO:0006244)4.91307682
25protein K6-linked ubiquitination (GO:0085020)4.85404650
26regulation of meiosis I (GO:0060631)4.78062156
27negative regulation of meiotic cell cycle (GO:0051447)4.61381921
28type B pancreatic cell development (GO:0003323)4.60078440
29regulation of RIG-I signaling pathway (GO:0039535)4.59581614
30regulation of acrosome reaction (GO:0060046)4.56466033
31regulation of plasminogen activation (GO:0010755)4.53108260
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.48477068
33peptidyl-glutamic acid carboxylation (GO:0017187)4.45649616
34protein carboxylation (GO:0018214)4.45649616
35multicellular organism reproduction (GO:0032504)4.42195426
36plasma lipoprotein particle assembly (GO:0034377)4.41099176
37metaphase plate congression (GO:0051310)4.40529966
38regulation of histone H3-K27 methylation (GO:0061085)4.36515155
39negative regulation of fatty acid biosynthetic process (GO:0045717)4.30233938
40attachment of spindle microtubules to kinetochore (GO:0008608)4.29071204
41establishment of chromosome localization (GO:0051303)4.27466153
42regulation of retinoic acid receptor signaling pathway (GO:0048385)4.24615839
43regulation of apoptotic cell clearance (GO:2000425)4.23374034
44negative regulation of reproductive process (GO:2000242)4.20907246
45lung epithelium development (GO:0060428)4.20810539
46gene silencing by RNA (GO:0031047)4.18113206
47meiotic chromosome segregation (GO:0045132)4.17186071
48regulation of sister chromatid cohesion (GO:0007063)4.15037012
49regulation of DNA methylation (GO:0044030)4.03444611
50regulation of transforming growth factor beta2 production (GO:0032909)4.01908730
51mitotic sister chromatid segregation (GO:0000070)3.98727699
52regulation of ARF GTPase activity (GO:0032312)3.93456512
53very-low-density lipoprotein particle assembly (GO:0034379)3.82386110
54regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.81351156
55maturation of 5.8S rRNA (GO:0000460)3.77335651
56microtubule severing (GO:0051013)3.75030244
57protein-lipid complex assembly (GO:0065005)3.68141940
58glandular epithelial cell development (GO:0002068)3.67996845
59female gonad development (GO:0008585)3.66697409
60ovulation cycle (GO:0042698)3.66244432
61regulation of protein activation cascade (GO:2000257)3.65167914
62notochord development (GO:0030903)3.63552225
63sphingosine metabolic process (GO:0006670)3.63536725
64cellular response to epidermal growth factor stimulus (GO:0071364)3.63025647
65negative regulation of hormone metabolic process (GO:0032351)3.62899969
66negative regulation of hormone biosynthetic process (GO:0032353)3.62899969
67DNA methylation (GO:0006306)3.61883652
68DNA alkylation (GO:0006305)3.61883652
69positive regulation of megakaryocyte differentiation (GO:0045654)3.60267734
70regulation of complement activation (GO:0030449)3.59406586
71glycerophospholipid catabolic process (GO:0046475)3.59299896
72phosphatidylglycerol biosynthetic process (GO:0006655)3.58262427
73stress granule assembly (GO:0034063)3.57559894
74vitamin transmembrane transport (GO:0035461)3.53409539
75histone H3-K4 trimethylation (GO:0080182)3.51799034
76proline biosynthetic process (GO:0006561)3.47967080
77chromosome segregation (GO:0007059)3.46487181
78histone H4 deacetylation (GO:0070933)3.46371526
79proline metabolic process (GO:0006560)3.46312044
80positive regulation of Cdc42 GTPase activity (GO:0043089)3.35590312
81semaphorin-plexin signaling pathway (GO:0071526)3.34538363
82positive regulation of meiosis (GO:0045836)3.33295146
83oocyte development (GO:0048599)3.32321641
84negative regulation of macroautophagy (GO:0016242)3.30481004
85N-terminal protein amino acid acetylation (GO:0006474)3.28656802
86fertilization (GO:0009566)3.28059526
87negative regulation of cell division (GO:0051782)3.27518654
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.27147684
89negative regulation of execution phase of apoptosis (GO:1900118)3.26472010
90reproduction (GO:0000003)3.24220586
91negative regulation of DNA-templated transcription, elongation (GO:0032785)3.24052379
92negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.24052379
93meiotic nuclear division (GO:0007126)3.23282167
94intestinal cholesterol absorption (GO:0030299)3.23098089
95activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.22561150
96negative regulation of cell size (GO:0045792)3.21470925
97entrainment of circadian clock by photoperiod (GO:0043153)3.21198486
98diol metabolic process (GO:0034311)3.19026031
99regulation of translational fidelity (GO:0006450)3.18708554
100positive regulation of nuclease activity (GO:0032075)3.15633216
101planar cell polarity pathway involved in neural tube closure (GO:0090179)3.14776961
102protein localization to chromosome (GO:0034502)3.14673780
103negative regulation of nuclear division (GO:0051784)3.14480800
104lung vasculature development (GO:0060426)3.13549079
105regulation of glucokinase activity (GO:0033131)3.12921888
106regulation of hexokinase activity (GO:1903299)3.12921888
107* oocyte maturation (GO:0001556)3.12706888
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11725810
109positive regulation of histone deacetylation (GO:0031065)3.11613779
110sister chromatid segregation (GO:0000819)3.11581318
111regulation of hypersensitivity (GO:0002883)3.10840736
112regulation of Golgi to plasma membrane protein transport (GO:0042996)3.10555777
113regulation of cholesterol metabolic process (GO:0090181)3.09656209
114positive regulation of CREB transcription factor activity (GO:0032793)3.09181595
115positive regulation of T cell apoptotic process (GO:0070234)3.09157593
116spindle checkpoint (GO:0031577)3.08684686
117plasma lipoprotein particle organization (GO:0071827)3.08426917
118positive regulation of meiotic cell cycle (GO:0051446)3.08304726
119regulation of cholesterol esterification (GO:0010872)3.08267754
120regulation of chromosome segregation (GO:0051983)3.08031657
121poly(A)+ mRNA export from nucleus (GO:0016973)3.07597243
122nephron epithelium morphogenesis (GO:0072088)3.05650091
123nephron tubule morphogenesis (GO:0072078)3.05650091
124histone monoubiquitination (GO:0010390)3.05484905
125regulation of spindle organization (GO:0090224)3.05233986
126protein monoubiquitination (GO:0006513)3.05047684
127synaptonemal complex assembly (GO:0007130)3.04765298
128protein localization to kinetochore (GO:0034501)3.02237541
129plasma lipoprotein particle remodeling (GO:0034369)3.00773969
130protein-lipid complex remodeling (GO:0034368)3.00773969
131macromolecular complex remodeling (GO:0034367)3.00773969
132high-density lipoprotein particle remodeling (GO:0034375)2.99391473
133positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.99300295
134phospholipid efflux (GO:0033700)2.99087434
135cholesterol efflux (GO:0033344)2.97860213
136low-density lipoprotein particle remodeling (GO:0034374)2.97748525
137regulation of mitotic spindle organization (GO:0060236)2.97288607
138response to epidermal growth factor (GO:0070849)2.96562895
139mitotic sister chromatid cohesion (GO:0007064)2.95599273
140mitotic nuclear envelope disassembly (GO:0007077)2.95067187
141snRNA metabolic process (GO:0016073)2.94843608
142synaptonemal complex organization (GO:0070193)2.92922147
143phosphatidylinositol acyl-chain remodeling (GO:0036149)2.92483430
144fibrinolysis (GO:0042730)2.92007765
145protein localization to chromosome, centromeric region (GO:0071459)2.90829006
146negative regulation of cholesterol transport (GO:0032375)2.89896325
147negative regulation of sterol transport (GO:0032372)2.89896325
148convergent extension (GO:0060026)2.89670270
149histone deubiquitination (GO:0016578)2.89587269
150snRNA processing (GO:0016180)2.89243484
151regulation of cholesterol biosynthetic process (GO:0045540)2.88781267
152single fertilization (GO:0007338)2.87730885
153meiotic cell cycle process (GO:1903046)2.87172986
154cell-cell junction maintenance (GO:0045217)2.87014482
155positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.87001457
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.86259240
157regulation of glucocorticoid metabolic process (GO:0031943)2.86162143
158oogenesis (GO:0048477)2.85176644
159regulation of nuclease activity (GO:0032069)2.84481920
160regulation of histone H3-K4 methylation (GO:0051569)2.83772247
161histone H3-K9 demethylation (GO:0033169)2.83004804
162mRNA cleavage (GO:0006379)2.79995382
163regulation of RNA export from nucleus (GO:0046831)2.79700652
164desmosome organization (GO:0002934)2.77774410
165protein-lipid complex subunit organization (GO:0071825)2.76672804
166insulin-like growth factor receptor signaling pathway (GO:0048009)2.76634698
167regulation of mammary gland epithelial cell proliferation (GO:0033599)2.76333781
168COPI coating of Golgi vesicle (GO:0048205)2.75865440
169Golgi transport vesicle coating (GO:0048200)2.75865440
170regulation of cholesterol homeostasis (GO:2000188)2.74577672
171negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.74022731
172pinocytosis (GO:0006907)2.71562068
173regulation of endothelial cell chemotaxis (GO:2001026)2.70723403
174triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.69981876
175sulfate transmembrane transport (GO:1902358)2.69309720
176L-serine metabolic process (GO:0006563)2.67709215
177positive regulation of extracellular matrix organization (GO:1903055)2.65765195
178histone H3 deacetylation (GO:0070932)2.64777365
179heterochromatin organization (GO:0070828)2.62483892
180diacylglycerol metabolic process (GO:0046339)2.62332443
181complement activation, alternative pathway (GO:0006957)2.62224115
182positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.58799746
183photoperiodism (GO:0009648)2.58709754
184positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.57231985
185regulation of fatty acid biosynthetic process (GO:0042304)2.56481088
186negative regulation of fatty acid transport (GO:2000192)2.56197127
187regulation of fatty acid beta-oxidation (GO:0031998)2.53232980
188endoplasmic reticulum unfolded protein response (GO:0030968)2.52367666
189activation of NF-kappaB-inducing kinase activity (GO:0007250)2.51680701
190apoptotic process involved in morphogenesis (GO:0060561)2.50118001
191negative regulation of fatty acid metabolic process (GO:0045922)2.49532736
192basement membrane organization (GO:0071711)2.48768919
193sulfate transport (GO:0008272)2.48568603
194trivalent inorganic anion homeostasis (GO:0072506)2.47706597
195phosphate ion homeostasis (GO:0055062)2.47706597
196endothelial cell chemotaxis (GO:0035767)2.47027822
197activation of Rac GTPase activity (GO:0032863)2.45992765
198regulation of extracellular matrix organization (GO:1903053)2.45466523

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.25428100
2KAP1_22055183_ChIP-Seq_ESCs_Mouse3.88519690
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.67869338
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.47087854
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.38406793
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.02777402
7MYC_22102868_ChIP-Seq_BL_Human2.93218266
8E2F7_22180533_ChIP-Seq_HELA_Human2.84540518
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.82495189
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.79528088
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.71972727
12AR_21909140_ChIP-Seq_LNCAP_Human2.71803109
13IGF1R_20145208_ChIP-Seq_DFB_Human2.55936663
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.50288399
15LXR_22292898_ChIP-Seq_THP-1_Human2.39685596
16VDR_21846776_ChIP-Seq_THP-1_Human2.30730548
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22114258
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19879251
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16511104
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16233346
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14468385
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13121768
23ESR1_15608294_ChIP-ChIP_MCF-7_Human2.12580461
24ZNF263_19887448_ChIP-Seq_K562_Human2.10289400
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.10022932
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06365020
27RACK7_27058665_Chip-Seq_MCF-7_Human2.05316064
28LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04851332
29TCF7_22412390_ChIP-Seq_EML_Mouse1.98817130
30RNF2_27304074_Chip-Seq_NSC_Mouse1.98052822
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91137094
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88947314
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.85560256
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85166808
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.82188500
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.79757133
37RUNX1_26923725_Chip-Seq_HPCs_Mouse1.79506773
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.78180139
39MYC_18940864_ChIP-ChIP_HL60_Human1.77694058
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76148140
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.74520408
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69394390
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68590958
44MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.67990332
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66806188
46STAT1_17558387_ChIP-Seq_HELA_Human1.66165063
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65712236
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65440056
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64727630
50KDM2B_26808549_Chip-Seq_DND41_Human1.64592367
51P68_20966046_ChIP-Seq_HELA_Human1.63118218
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61512101
53SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.61273248
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60092761
55MAF_26560356_Chip-Seq_TH2_Human1.53885311
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.53832051
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.53487721
58GATA3_21867929_ChIP-Seq_TH1_Mouse1.53443528
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51489058
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51135962
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.50821654
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49916487
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49725991
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.49598313
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.45734394
66NCOR1_26117541_ChIP-Seq_K562_Human1.45689328
67* SMC4_20622854_ChIP-Seq_HELA_Human1.42494174
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.39986557
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.39920881
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39516752
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39492139
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.39162791
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.38753378
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38701128
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.37850102
76KDM2B_26808549_Chip-Seq_K562_Human1.37306983
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.37240906
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36944102
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36698407
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36658747
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35038294
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34675667
83FOXA2_19822575_ChIP-Seq_HepG2_Human1.34516884
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34458525
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34205603
86* ATF3_27146783_Chip-Seq_COLON_Human1.34148905
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34146863
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33015579
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32623812
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32445996
91CIITA_25753668_ChIP-Seq_RAJI_Human1.30881114
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30553046
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30211561
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.29775759
95TP53_22127205_ChIP-Seq_IMR90_Human1.29391572
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.29020282
97STAT3_23295773_ChIP-Seq_U87_Human1.28245472
98CREB1_26743006_Chip-Seq_LNCaP_Human1.28066574
99SA1_27219007_Chip-Seq_ERYTHROID_Human1.28065565
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26701318
101CDX2_22108803_ChIP-Seq_LS180_Human1.26618759
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26544140
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26500762
104RARB_24833708_ChIP-Seq_LIVER_Mouse1.26488877
105SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26445904
106FUS_26573619_Chip-Seq_HEK293_Human1.25742067
107MAF_26560356_Chip-Seq_TH1_Human1.25549788
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24146602
109RARA_24833708_ChIP-Seq_LIVER_Mouse1.23615248
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23291037
111BP1_19119308_ChIP-ChIP_Hs578T_Human1.22100913
112* KLF4_18555785_Chip-Seq_ESCs_Mouse1.21987158
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.21545878
114KDM5A_27292631_Chip-Seq_BREAST_Human1.21236410
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21230427
116STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20970226
117* CTCF_18555785_Chip-Seq_ESCs_Mouse1.20937651
118STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20208749
119SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.18313799
120POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18174350
121UTX_26944678_Chip-Seq_JUKART_Human1.17336266
122BCOR_27268052_Chip-Seq_Bcells_Human1.16894336
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16789479
124KDM2B_26808549_Chip-Seq_REH_Human1.16533380
125KDM2B_26808549_Chip-Seq_JURKAT_Human1.15494924
126ZFX_18555785_Chip-Seq_ESCs_Mouse1.15152829
127* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14960582
128EWS_26573619_Chip-Seq_HEK293_Human1.13577802
129RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13575267
130KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13445008
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13367014
132* GABP_19822575_ChIP-Seq_HepG2_Human1.12273881
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11547440
134ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11447623
135E2F1_20622854_ChIP-Seq_HELA_Human1.11264254
136MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11262218
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10748573
138FOXP1_21924763_ChIP-Seq_HESCs_Human1.10374752
139KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09025810
140NFYA_21822215_ChIP-Seq_K562_Human1.08672753
141OCT4_18555785_Chip-Seq_ESCs_Mouse1.08434370
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08412953
143RUNX1_22412390_ChIP-Seq_EML_Mouse1.08218967
144EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07952827
145LXR_22158963_ChIP-Seq_LIVER_Mouse1.07628989
146SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07450355
147NANOG_21062744_ChIP-ChIP_HESCs_Human1.07079965
148BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07028277
149EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06513176
150ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06175922
151CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06006761
152MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05361596
153MYC_18555785_ChIP-Seq_MESCs_Mouse1.05205725
154PHF8_20622854_ChIP-Seq_HELA_Human1.05179253
155GATA6_25053715_ChIP-Seq_YYC3_Human1.04645413
156NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04590839
157* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04068810
158MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03563657
159HTT_18923047_ChIP-ChIP_STHdh_Human1.03116668
160OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03042200
161GF1B_26923725_Chip-Seq_HPCs_Mouse1.02778086
162BCL6_27268052_Chip-Seq_Bcells_Human1.02728233
163CLOCK_20551151_ChIP-Seq_293T_Human1.02211189
164CRX_20693478_ChIP-Seq_RETINA_Mouse1.02052010
165ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01329952
166GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00667677
167TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00558968
168ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00183177
169KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99997699
170CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99640450
171TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99559881
172TP63_19390658_ChIP-ChIP_HaCaT_Human0.99415615
173P53_22387025_ChIP-Seq_ESCs_Mouse0.99329808
174XRN2_22483619_ChIP-Seq_HELA_Human0.99311621
175ERG_20517297_ChIP-Seq_VCAP_Human0.99262153
176CMYC_18555785_Chip-Seq_ESCs_Mouse0.96971509
177FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96491831
178SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96483708
179TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96436673
180TAL1_26923725_Chip-Seq_HPCs_Mouse0.95712579
181LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94926692
182CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94204986
183MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92772013
184GATA3_26560356_Chip-Seq_TH1_Human0.92064834
185RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91397657
186E2F1_18555785_Chip-Seq_ESCs_Mouse0.90859818
187AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90092317
188HNFA_21074721_ChIP-Seq_CACO-2_Human0.89175340
189KAP1_27257070_Chip-Seq_ESCs_Mouse0.88989489
190SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86436627
191FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.83273208
192CJUN_26792858_Chip-Seq_BT549_Human0.81916625
193E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81624612
194CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81446901
195ESR1_20079471_ChIP-ChIP_T-47D_Human0.80655955
196ETV1_20927104_ChIP-Seq_GIST48_Human0.80592759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.89574119
2MP0003646_muscle_fatigue5.64450904
3MP0005451_abnormal_body_composition4.80823263
4MP0008877_abnormal_DNA_methylation4.11079606
5MP0003172_abnormal_lysosome_physiology3.75250783
6MP0003693_abnormal_embryo_hatching3.57746995
7MP0002102_abnormal_ear_morphology3.17413415
8MP0005646_abnormal_pituitary_gland3.07041306
9MP0005365_abnormal_bile_salt2.98215519
10MP0008875_abnormal_xenobiotic_pharmacok2.92446973
11MP0003699_abnormal_female_reproductive2.86711106
12MP0001119_abnormal_female_reproductive2.76580598
13MP0005058_abnormal_lysosome_morphology2.75644144
14MP0006292_abnormal_olfactory_placode2.71056149
15MP0010094_abnormal_chromosome_stability2.69216226
16MP0002396_abnormal_hematopoietic_system2.63685361
17MP0005395_other_phenotype2.62516246
18MP0000566_synostosis2.55875068
19MP0005076_abnormal_cell_differentiation2.55148353
20MP0005408_hypopigmentation2.48810751
21MP0003705_abnormal_hypodermis_morpholog2.46366816
22MP0000678_abnormal_parathyroid_gland2.42559514
23MP0001849_ear_inflammation2.31030661
24MP0001929_abnormal_gametogenesis2.28028195
25MP0003123_paternal_imprinting2.20862958
26MP0003787_abnormal_imprinting2.19212027
27MP0003122_maternal_imprinting2.18947708
28MP0005257_abnormal_intraocular_pressure2.17808778
29MP0003077_abnormal_cell_cycle2.16465998
30MP0003111_abnormal_nucleus_morphology2.16314855
31MP0000653_abnormal_sex_gland2.13844985
32MP0002249_abnormal_larynx_morphology2.00408881
33MP0010386_abnormal_urinary_bladder1.99485969
34MP0000579_abnormal_nail_morphology1.98485876
35MP0002210_abnormal_sex_determination1.98282683
36MP0003315_abnormal_perineum_morphology1.98040978
37MP0003121_genomic_imprinting1.93644814
38MP0006072_abnormal_retinal_apoptosis1.90247334
39MP0003566_abnormal_cell_adhesion1.80734112
40MP0004381_abnormal_hair_follicle1.72896352
41MP0002837_dystrophic_cardiac_calcinosis1.71748147
42MP0002139_abnormal_hepatobiliary_system1.68648668
43MP0002653_abnormal_ependyma_morphology1.68385976
44MP0003436_decreased_susceptibility_to1.67259648
45MP0004957_abnormal_blastocyst_morpholog1.66670360
46MP0002089_abnormal_postnatal_growth/wei1.62749543
47MP0001661_extended_life_span1.59107912
48MP0005377_hearing/vestibular/ear_phenot1.58564628
49MP0003878_abnormal_ear_physiology1.58564628
50MP0010368_abnormal_lymphatic_system1.53609562
51MP0008260_abnormal_autophagy1.51822614
52MP0005187_abnormal_penis_morphology1.51371917
53MP0005310_abnormal_salivary_gland1.50224581
54MP0003937_abnormal_limbs/digits/tail_de1.48799953
55MP0005409_darkened_coat_color1.47671463
56MP0002132_abnormal_respiratory_system1.46161847
57MP0001348_abnormal_lacrimal_gland1.44880827
58MP0000858_altered_metastatic_potential1.43486477
59MP0002161_abnormal_fertility/fecundity1.43137825
60MP0002877_abnormal_melanocyte_morpholog1.42683639
61MP0001145_abnormal_male_reproductive1.35152155
62MP0002638_abnormal_pupillary_reflex1.32157961
63MP0000003_abnormal_adipose_tissue1.31042412
64MP0001502_abnormal_circadian_rhythm1.29594364
65MP0004858_abnormal_nervous_system1.27776346
66MP0010329_abnormal_lipoprotein_level1.24517187
67MP0008932_abnormal_embryonic_tissue1.23758774
68MP0003115_abnormal_respiratory_system1.22567960
69MP0002933_joint_inflammation1.21945518
70MP0000462_abnormal_digestive_system1.21247753
71MP0010234_abnormal_vibrissa_follicle1.20752550
72MP0000609_abnormal_liver_physiology1.16888918
73MP0005023_abnormal_wound_healing1.15326741
74MP0005666_abnormal_adipose_tissue1.14029063
75MP0001666_abnormal_nutrient_absorption1.13487491
76MP0004782_abnormal_surfactant_physiolog1.12282166
77MP0004233_abnormal_muscle_weight1.11969088
78MP0000613_abnormal_salivary_gland1.10263348
79MP0005220_abnormal_exocrine_pancreas1.09219082
80MP0003943_abnormal_hepatobiliary_system1.08550491
81MP0003252_abnormal_bile_duct1.07325298
82MP0002163_abnormal_gland_morphology1.05907149
83MP0004197_abnormal_fetal_growth/weight/1.02441488
84MP0001853_heart_inflammation1.02301832
85MP0005379_endocrine/exocrine_gland_phen1.01876466
86MP0001529_abnormal_vocalization1.01032302
87MP0001270_distended_abdomen1.00670294
88MP0003191_abnormal_cellular_cholesterol0.98704598
89MP0000639_abnormal_adrenal_gland0.98174596
90MP0004808_abnormal_hematopoietic_stem0.97907441
91MP0002085_abnormal_embryonic_tissue0.97115755
92MP0000371_diluted_coat_color0.96020932
93MP0001919_abnormal_reproductive_system0.95887761
94MP0009840_abnormal_foam_cell0.94929744
95MP0002282_abnormal_trachea_morphology0.94580846
96MP0004510_myositis0.94514309
97MP0008058_abnormal_DNA_repair0.93141828
98MP0010030_abnormal_orbit_morphology0.92570063
99MP0000537_abnormal_urethra_morphology0.91538549
100MP0001873_stomach_inflammation0.91440792
101MP0001944_abnormal_pancreas_morphology0.90695003
102MP0000598_abnormal_liver_morphology0.90500061
103MP0004185_abnormal_adipocyte_glucose0.89634506
104MP0009278_abnormal_bone_marrow0.89538538
105MP0002693_abnormal_pancreas_physiology0.88937368
106MP0002970_abnormal_white_adipose0.87814261
107MP0003984_embryonic_growth_retardation0.87545961
108MP0002177_abnormal_outer_ear0.87005630
109MP0002075_abnormal_coat/hair_pigmentati0.86971818
110MP0001905_abnormal_dopamine_level0.86724182
111MP0004264_abnormal_extraembryonic_tissu0.86290990
112MP0001730_embryonic_growth_arrest0.85502041
113MP0002295_abnormal_pulmonary_circulatio0.84496591
114MP0002086_abnormal_extraembryonic_tissu0.84100515
115MP0005389_reproductive_system_phenotype0.83058495
116MP0004947_skin_inflammation0.82372756
117MP0002088_abnormal_embryonic_growth/wei0.82106299
118MP0003195_calcinosis0.82080226
119MP0005375_adipose_tissue_phenotype0.81803649
120MP0000490_abnormal_crypts_of0.78814899
121MP0002080_prenatal_lethality0.77911491
122MP0002925_abnormal_cardiovascular_devel0.77012923
123MP0000350_abnormal_cell_proliferation0.76893814
124MP0000631_abnormal_neuroendocrine_gland0.76484291
125MP0002019_abnormal_tumor_incidence0.76475921
126MP0001764_abnormal_homeostasis0.74462659
127MP0009697_abnormal_copulation0.74453703
128MP0009384_cardiac_valve_regurgitation0.73403070
129MP0002084_abnormal_developmental_patter0.71902237
130MP0002932_abnormal_joint_morphology0.70671819
131MP0003950_abnormal_plasma_membrane0.70606994
132MP0003698_abnormal_male_reproductive0.69867500
133MP0001286_abnormal_eye_development0.69606876
134MP0003890_abnormal_embryonic-extraembry0.69125376
135MP0001186_pigmentation_phenotype0.68782146
136MP0002098_abnormal_vibrissa_morphology0.68715910
137MP0002697_abnormal_eye_size0.68314816
138MP0002405_respiratory_system_inflammati0.68303893
139MP0009931_abnormal_skin_appearance0.68298301
140MP0003942_abnormal_urinary_system0.67843941
141MP0000703_abnormal_thymus_morphology0.67841852
142MP0001697_abnormal_embryo_size0.66827774
143MP0008007_abnormal_cellular_replicative0.65047111
144MP0002118_abnormal_lipid_homeostasis0.64941872
145MP0000465_gastrointestinal_hemorrhage0.64265054
146MP0005085_abnormal_gallbladder_physiolo0.64079661
147MP0009333_abnormal_splenocyte_physiolog0.63904452
148MP0010630_abnormal_cardiac_muscle0.63310972
149MP0001672_abnormal_embryogenesis/_devel0.61564070
150MP0005380_embryogenesis_phenotype0.61564070
151MP0003656_abnormal_erythrocyte_physiolo0.59923663
152MP0004036_abnormal_muscle_relaxation0.59527585
153MP0001915_intracranial_hemorrhage0.58302279
154MP0003755_abnormal_palate_morphology0.57780432
155MP0000569_abnormal_digit_pigmentation0.56785245
156MP0003763_abnormal_thymus_physiology0.56462301
157MP0000534_abnormal_ureter_morphology0.55407654
158MP0004270_analgesia0.55117585
159MP0003935_abnormal_craniofacial_develop0.54238668
160MP0005360_urolithiasis0.54099971
161MP0002928_abnormal_bile_duct0.52942871
162MP0001346_abnormal_lacrimal_gland0.52113298
163MP0005621_abnormal_cell_physiology0.52054256
164MP0000427_abnormal_hair_cycle0.51532435
165MP0003453_abnormal_keratinocyte_physiol0.50692691
166MP0005381_digestive/alimentary_phenotyp0.49319172
167MP0002116_abnormal_craniofacial_bone0.46746742

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.10352801
2Deep venous thrombosis (HP:0002625)6.57747388
3Flat capital femoral epiphysis (HP:0003370)4.73975388
4Hypoplasia of the fovea (HP:0007750)4.66548118
5Aplasia/Hypoplasia of the fovea (HP:0008060)4.66548118
6Infertility (HP:0000789)4.58677685
7Abnormality of the fovea (HP:0000493)4.56585589
8Premature ovarian failure (HP:0008209)4.44304955
9Chromsome breakage (HP:0040012)4.28026551
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.11438845
11Papillary thyroid carcinoma (HP:0002895)4.09669621
12Cervical subluxation (HP:0003308)3.96956950
13Biconcave vertebral bodies (HP:0004586)3.93324403
14Secondary amenorrhea (HP:0000869)3.89449582
15Broad face (HP:0000283)3.86290526
16Hypergonadotropic hypogonadism (HP:0000815)3.83100523
17Flat acetabular roof (HP:0003180)3.75711125
18Prolonged partial thromboplastin time (HP:0003645)3.67711959
19Insulin-resistant diabetes mellitus (HP:0000831)3.65861924
20J-shaped sella turcica (HP:0002680)3.63657455
21Adrenal hypoplasia (HP:0000835)3.62255559
22Cortical dysplasia (HP:0002539)3.59854798
23Spondylolisthesis (HP:0003302)3.57424007
24Shawl scrotum (HP:0000049)3.54679349
25Pulmonary fibrosis (HP:0002206)3.39940941
26Hemorrhage of the eye (HP:0011885)3.22647771
27Patellar aplasia (HP:0006443)3.20999530
28Lip pit (HP:0100267)3.17182932
29Arterial tortuosity (HP:0005116)3.16732366
30Pancreatic fibrosis (HP:0100732)3.03566177
31Atelectasis (HP:0100750)3.02868372
32Joint hemorrhage (HP:0005261)3.00419935
33Menorrhagia (HP:0000132)2.99276243
34Aplasia/Hypoplasia of the macula (HP:0008059)2.98286582
35Breast hypoplasia (HP:0003187)2.97690456
36Anosmia (HP:0000458)2.97310571
37Aplasia/Hypoplasia of the patella (HP:0006498)2.93795287
38Facial hemangioma (HP:0000329)2.91572708
39Aplasia/Hypoplasia of the breasts (HP:0010311)2.90758890
40Breast aplasia (HP:0100783)2.89446857
41Protrusio acetabuli (HP:0003179)2.87144312
42Hypoplasia of the capital femoral epiphysis (HP:0003090)2.82689264
43Abnormality of the fingertips (HP:0001211)2.81468711
44Abnormality of chromosome segregation (HP:0002916)2.75801415
45Thin bony cortex (HP:0002753)2.74587643
46Birth length less than 3rd percentile (HP:0003561)2.70972292
4711 pairs of ribs (HP:0000878)2.69664718
48Primary amenorrhea (HP:0000786)2.68286345
49Abnormality of carpal bone ossification (HP:0006257)2.67596713
50Aplasia/Hypoplasia affecting the retina (HP:0008061)2.67038493
51Hyperglycemia (HP:0003074)2.66146637
52Vascular tortuosity (HP:0004948)2.65851143
53Obstructive sleep apnea (HP:0002870)2.64377763
54Anterior segment dysgenesis (HP:0007700)2.58454367
55Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.57769334
56Absent epiphyses (HP:0010577)2.57769334
57Hypogonadotrophic hypogonadism (HP:0000044)2.57291200
58Acute myeloid leukemia (HP:0004808)2.54712846
59Abnormality of the labia minora (HP:0012880)2.47276558
60Abnormality of the epiphysis of the femoral head (HP:0010574)2.46284326
61Pancreatic cysts (HP:0001737)2.45340883
62Type 2 muscle fiber atrophy (HP:0003554)2.43467568
63Hyperacusis (HP:0010780)2.43162596
64Dislocated radial head (HP:0003083)2.42254750
65Molar tooth sign on MRI (HP:0002419)2.42244408
66Abnormality of midbrain morphology (HP:0002418)2.42244408
67Mucopolysacchariduria (HP:0008155)2.42225739
68Urinary glycosaminoglycan excretion (HP:0003541)2.42225739
69Aplastic anemia (HP:0001915)2.38087112
70Flared iliac wings (HP:0002869)2.36558468
71Small epiphyses (HP:0010585)2.35632899
72Abnormality of the femoral head (HP:0003368)2.34515450
73Nonprogressive disorder (HP:0003680)2.34354082
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.33834084
75Muscle fiber atrophy (HP:0100295)2.31206129
76True hermaphroditism (HP:0010459)2.30360722
77Wide nose (HP:0000445)2.29950356
78Erectile abnormalities (HP:0100639)2.29477979
79Supernumerary spleens (HP:0009799)2.29121682
80Upper limb amyotrophy (HP:0009129)2.28579818
81Distal upper limb amyotrophy (HP:0007149)2.28579818
82Metaphyseal cupping (HP:0003021)2.28363348
83Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.28034077
84Abnormality of femoral epiphyses (HP:0006499)2.28034077
85Chronic bronchitis (HP:0004469)2.27315518
86Entropion (HP:0000621)2.26273113
87Abnormality of the common coagulation pathway (HP:0010990)2.25897399
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.25259927
89Abnormality of polysaccharide metabolism (HP:0011012)2.25259927
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.25259927
91Seborrheic dermatitis (HP:0001051)2.24100758
92Carpal bone hypoplasia (HP:0001498)2.23969706
93Complement deficiency (HP:0004431)2.23400029
94Cystic liver disease (HP:0006706)2.23362277
95Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23164487
96Xanthomatosis (HP:0000991)2.22868828
97Broad alveolar ridges (HP:0000187)2.22814824
98Sandal gap (HP:0001852)2.21556847
99Epiphyseal dysplasia (HP:0002656)2.20942029
100Abnormality of calcium-phosphate metabolism (HP:0100530)2.20110380
101Abnormality of the radial head (HP:0003995)2.19259930
102Poikiloderma (HP:0001029)2.17141763
103Abnormality of macular pigmentation (HP:0008002)2.15222862
104Capillary hemangiomas (HP:0005306)2.14834066
105Abnormality of the proximal phalanges of the hand (HP:0009834)2.13311448
106Hypercholesterolemia (HP:0003124)2.11979965
107Abnormality of complement system (HP:0005339)2.11410234
108Cystic hygroma (HP:0000476)2.09299434
109Oligodactyly (hands) (HP:0001180)2.09267576
110Delayed puberty (HP:0000823)2.08561248
111Ulnar bowing (HP:0003031)2.08191849
112Abnormal ossification of hand bones (HP:0005921)2.07761068
113Abnormality of cochlea (HP:0000375)2.07601044
114Heterotopia (HP:0002282)2.05205979
115Overlapping toe (HP:0001845)2.04618559
116Abnormality of the acetabulum (HP:0003170)2.04037825
117Hand muscle atrophy (HP:0009130)2.03026944
118Cupped ribs (HP:0000887)2.02851554
119Abnormality of the nasal septum (HP:0000419)2.02820500
120Malnutrition (HP:0004395)2.01801192
121Dysostosis multiplex (HP:0000943)2.00563330
122Asymmetry of the thorax (HP:0001555)2.00131051
123Stridor (HP:0010307)1.99691690
124Hypobetalipoproteinemia (HP:0003563)1.99504847
125Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98956105
126Disproportionate tall stature (HP:0001519)1.98677574
127Thyroid carcinoma (HP:0002890)1.97812231
128Abnormality of chromosome stability (HP:0003220)1.97633949
129Irregular epiphyses (HP:0010582)1.97371830
130Sloping forehead (HP:0000340)1.96957854
131Squamous cell carcinoma (HP:0002860)1.95735387
132Abnormality of DNA repair (HP:0003254)1.95610462
133Cerebral aneurysm (HP:0004944)1.93935060
134Occipital encephalocele (HP:0002085)1.93751921
135Fibular aplasia (HP:0002990)1.92461374
136Reticulocytosis (HP:0001923)1.92200041
137Myelodysplasia (HP:0002863)1.92166830
138Abnormality of the renal collecting system (HP:0004742)1.89591659
139Aplasia/Hypoplasia of the uvula (HP:0010293)1.89164323
140Bronchiectasis (HP:0002110)1.89003997
141Abnormal hair laboratory examination (HP:0003328)1.88844892
142Abnormal vertebral ossification (HP:0100569)1.87331080
143Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.86628582
144Fetal akinesia sequence (HP:0001989)1.86100267
145Abnormality of the thoracic spine (HP:0100711)1.82849822
146Hypoplastic iliac wings (HP:0002866)1.82070208
147Abnormality of pyrimidine metabolism (HP:0004353)1.81291241
148Bronchomalacia (HP:0002780)1.80704009
149Combined immunodeficiency (HP:0005387)1.79222717
150Abnormal hand bone ossification (HP:0010660)1.79004854
151Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77632492
152Broad palm (HP:0001169)1.76570915
153Tetany (HP:0001281)1.75972292
154Leiomyosarcoma (HP:0100243)1.75005904
155Uterine leiomyosarcoma (HP:0002891)1.75005904
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.74780964
157Widely patent fontanelles and sutures (HP:0004492)1.73861823
158Self-mutilation (HP:0000742)1.72473560
159Abnormality of the preputium (HP:0100587)1.70518397
160Hypophosphatemic rickets (HP:0004912)1.70072831
161Abnormality of the renal medulla (HP:0100957)1.69801839
162Arachnodactyly (HP:0001166)1.68882276
163Mitral regurgitation (HP:0001653)1.68344438
164Joint stiffness (HP:0001387)1.68330913
165Deformed sella turcica (HP:0002681)1.66836898
166Blue sclerae (HP:0000592)1.66106378
167Hirsutism (HP:0001007)1.65589440
168Long palpebral fissure (HP:0000637)1.65101216
169Vaginal fistula (HP:0004320)1.65009609
170Enlarged penis (HP:0000040)1.63883406
171Long toe (HP:0010511)1.63444087
172Nuclear cataract (HP:0100018)1.63032615
173Abnormality of dentin (HP:0010299)1.62388432
174Abnormality of the aortic arch (HP:0012303)1.62227535
175Limited elbow extension (HP:0001377)1.62173892
176Wrist flexion contracture (HP:0001239)1.61557930
177Aortic regurgitation (HP:0001659)1.61322152
178Syringomyelia (HP:0003396)1.60756874
179Spinal cord lesions (HP:0100561)1.60756874
180Bell-shaped thorax (HP:0001591)1.60596559
181Meckel diverticulum (HP:0002245)1.59894162
182Abnormality of lateral ventricle (HP:0030047)1.59799312
183Abnormality of placental membranes (HP:0011409)1.59474316
184Amniotic constriction ring (HP:0009775)1.59474316
185Rhizomelia (HP:0008905)1.58550357
186Lymphangioma (HP:0100764)1.57911030
187Abnormality of reticulocytes (HP:0004312)1.57690122
188Renal duplication (HP:0000075)1.57355802
189Ankyloglossia (HP:0010296)1.57332255
190Oligodontia (HP:0000677)1.57034336
191Hypopigmentation of the fundus (HP:0007894)1.56155251
192Peritonitis (HP:0002586)1.56139601
193Focal segmental glomerulosclerosis (HP:0000097)1.54176738
194Abnormal tarsal ossification (HP:0008369)1.53569618

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.78707589
2MAP3K64.54847569
3EEF2K3.96013965
4ERBB43.84195561
5FGFR43.64743409
6BRAF3.63634607
7TAOK33.53140848
8ERN13.46873255
9MUSK3.19885898
10KSR23.19763677
11SIK13.04730171
12PRKD32.97432133
13PLK42.96130360
14TTK2.92396187
15MAP2K32.69162542
16LATS12.63374149
17MAP3K92.59207522
18LATS22.57483836
19MOS2.52336053
20EPHA22.47353238
21MAP3K132.41182379
22MAPKAPK32.38477732
23ICK2.34628741
24SMG12.32958255
25ARAF2.32775109
26PKN22.15890555
27STK38L2.15333228
28MAP2K62.15265829
29MST1R2.04830766
30BMPR22.03836417
31MET2.02555665
32PDGFRA2.00089838
33CDK81.97584339
34WNK41.96923398
35MAPKAPK51.96228280
36RAF11.93913241
37FLT31.92341580
38MAP3K71.83499336
39FGFR31.75765117
40SIK21.72125586
41WNK11.71085330
42TYRO31.66549988
43MELK1.65736038
44CDK91.64370401
45TAOK11.54287375
46MAP3K101.47820384
47STK101.47685957
48TRPM71.42107671
49MAPK131.41654666
50MAP4K11.41121850
51FGFR21.37764266
52NTRK11.34898371
53STK31.32403002
54IRAK31.30268746
55LMTK21.27547975
56TNK21.22354102
57PAK61.20827576
58ZAP701.20152812
59NEK21.18070147
60MTOR1.16953195
61GRK61.14857414
62PLK11.14453174
63RPS6KB21.11979698
64CHEK21.11806657
65PRKD21.10053408
66KSR11.08882286
67MAP3K41.08679993
68CDC71.08614379
69CDC42BPA1.06544837
70NME11.04508661
71PTK61.04152134
72MAP3K141.02952636
73MAP3K80.99582036
74ACVR1B0.92848800
75CAMK1D0.92524264
76TYK20.92059770
77NLK0.83841154
78FGFR10.82959790
79RIPK10.78994085
80CDK40.78070839
81PDGFRB0.77405839
82EPHB10.77405217
83BRD40.76760061
84DYRK20.75716437
85PIK3CA0.74649516
86STK240.73407710
87DYRK30.72239496
88MAP2K70.72022962
89PAK40.71830816
90DMPK0.71251228
91ABL20.69665812
92BMX0.69442129
93CAMK1G0.68827324
94BRSK20.68640069
95MAPK110.66963175
96EPHA30.65716614
97ERBB20.64635926
98JAK30.63237832
99RIPK40.63027582
100PRKAA20.61774114
101SGK20.61671016
102AURKB0.57796897
103SIK30.56357027
104PLK30.56134097
105PINK10.55538328
106PDPK10.55137712
107RET0.53363213
108NEK90.52858921
109PRKAA10.52346028
110AURKA0.52219691
111MAP3K10.51248453
112DYRK1A0.50509341
113MAP3K50.48195529
114CDK120.47826670
115DYRK1B0.45437817
116HIPK20.43482182
117MAPKAPK20.42837610
118CSNK1G20.42274067
119MATK0.42061158
120CSNK1G10.41633882
121SGK2230.41405547
122SGK4940.41405547
123MARK20.40982932
124FRK0.40609081
125RPS6KL10.40453212
126RPS6KC10.40453212
127PRPF4B0.40209167
128IRAK40.39933614
129DDR20.39696411
130CHUK0.39016326
131CSNK1G30.38871241
132FGR0.38642270
133TBK10.37975050
134ATM0.37791309
135ITK0.37762112
136PIK3CG0.37406753
137EIF2AK30.36678922
138PDK10.35972765
139MAP2K40.35696495
140PTK20.35024274
141BUB10.34176653
142CDK20.34064978
143MARK30.34000426
144RPS6KA20.33829466
145LRRK20.33212479
146MAPK30.32291557
147ABL10.31939088
148CSF1R0.31653619
149WNK30.30544695
150BTK0.30099889
151MAP3K30.30097209
152STK380.29807282
153CSNK1A1L0.27860656
154RPS6KA40.27100036
155CDK70.26627360
156MAP2K10.25187666
157NUAK10.24910389
158CHEK10.24824480
159TAOK20.24359662
160ATR0.23665590
161TEC0.22191327
162CAMK2A0.21724897
163JAK20.19965044
164CDK10.19600859
165AKT10.18754817
166BMPR1B0.17583776
167PASK0.16764333
168SGK30.16463735
169INSRR0.14672595
170BRSK10.14408244
171CDK30.12915884
172MAPK150.12870949

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.13857735
2Cell cycle_Homo sapiens_hsa041103.59174409
3Circadian rhythm_Homo sapiens_hsa047103.20471215
4* RNA degradation_Homo sapiens_hsa030183.12690783
5Basal transcription factors_Homo sapiens_hsa030223.09622511
6Complement and coagulation cascades_Homo sapiens_hsa046103.05805762
7Cyanoamino acid metabolism_Homo sapiens_hsa004603.05370635
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.68078327
9Linoleic acid metabolism_Homo sapiens_hsa005912.65785333
10Vitamin B6 metabolism_Homo sapiens_hsa007502.52026914
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.33421084
12Homologous recombination_Homo sapiens_hsa034402.32505846
13Pancreatic cancer_Homo sapiens_hsa052122.15272241
14Fanconi anemia pathway_Homo sapiens_hsa034602.12869496
15ABC transporters_Homo sapiens_hsa020102.10223768
16Other glycan degradation_Homo sapiens_hsa005112.06473524
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.05238165
18Ether lipid metabolism_Homo sapiens_hsa005652.01843165
19GnRH signaling pathway_Homo sapiens_hsa049121.99800398
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.94766841
21Base excision repair_Homo sapiens_hsa034101.87653130
22Oocyte meiosis_Homo sapiens_hsa041141.84409803
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79724422
24One carbon pool by folate_Homo sapiens_hsa006701.79581561
25Prolactin signaling pathway_Homo sapiens_hsa049171.66631060
26Non-homologous end-joining_Homo sapiens_hsa034501.60007645
27Dorso-ventral axis formation_Homo sapiens_hsa043201.53810446
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51539586
29p53 signaling pathway_Homo sapiens_hsa041151.44646825
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41837931
31Acute myeloid leukemia_Homo sapiens_hsa052211.38482675
32RNA polymerase_Homo sapiens_hsa030201.36123103
33TGF-beta signaling pathway_Homo sapiens_hsa043501.35270367
34Colorectal cancer_Homo sapiens_hsa052101.26736236
35* RNA transport_Homo sapiens_hsa030131.25225943
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23547668
37Vitamin digestion and absorption_Homo sapiens_hsa049771.23491736
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23409649
39Choline metabolism in cancer_Homo sapiens_hsa052311.22533362
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22453855
41Fructose and mannose metabolism_Homo sapiens_hsa000511.22057193
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21044283
43Insulin resistance_Homo sapiens_hsa049311.20470941
44Biosynthesis of amino acids_Homo sapiens_hsa012301.17651680
45N-Glycan biosynthesis_Homo sapiens_hsa005101.15118742
46Protein export_Homo sapiens_hsa030601.13890183
47Arginine biosynthesis_Homo sapiens_hsa002201.12955469
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12671252
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10009980
50Bile secretion_Homo sapiens_hsa049761.07846358
51VEGF signaling pathway_Homo sapiens_hsa043701.06151291
52Glycerophospholipid metabolism_Homo sapiens_hsa005641.01056789
53mTOR signaling pathway_Homo sapiens_hsa041501.00877365
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99743021
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99476571
56MicroRNAs in cancer_Homo sapiens_hsa052060.98452177
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.97663860
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96932111
59Mismatch repair_Homo sapiens_hsa034300.96528718
60Spliceosome_Homo sapiens_hsa030400.96296816
61FoxO signaling pathway_Homo sapiens_hsa040680.96220650
62Sphingolipid metabolism_Homo sapiens_hsa006000.95231385
63Renal cell carcinoma_Homo sapiens_hsa052110.94650855
64Insulin signaling pathway_Homo sapiens_hsa049100.93262820
65* mRNA surveillance pathway_Homo sapiens_hsa030150.90425478
66Shigellosis_Homo sapiens_hsa051310.90233451
67Staphylococcus aureus infection_Homo sapiens_hsa051500.89411318
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.88734215
69Chronic myeloid leukemia_Homo sapiens_hsa052200.88704615
70Fatty acid degradation_Homo sapiens_hsa000710.87460322
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86256140
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.84355769
73Long-term depression_Homo sapiens_hsa047300.83779925
74Hepatitis C_Homo sapiens_hsa051600.81057844
75Adherens junction_Homo sapiens_hsa045200.80999785
76ECM-receptor interaction_Homo sapiens_hsa045120.79808033
77Arachidonic acid metabolism_Homo sapiens_hsa005900.79495055
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76718616
79Bladder cancer_Homo sapiens_hsa052190.76629425
80B cell receptor signaling pathway_Homo sapiens_hsa046620.76582239
81Endometrial cancer_Homo sapiens_hsa052130.76541114
82Nucleotide excision repair_Homo sapiens_hsa034200.75270726
83Fatty acid metabolism_Homo sapiens_hsa012120.74633532
84Fat digestion and absorption_Homo sapiens_hsa049750.74615964
85Inositol phosphate metabolism_Homo sapiens_hsa005620.74274908
86Thyroid cancer_Homo sapiens_hsa052160.73869287
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72342667
88Ras signaling pathway_Homo sapiens_hsa040140.71328107
89Purine metabolism_Homo sapiens_hsa002300.71241054
90Hepatitis B_Homo sapiens_hsa051610.69838722
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.68188170
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67422919
93Selenocompound metabolism_Homo sapiens_hsa004500.66409270
94Lysine degradation_Homo sapiens_hsa003100.62948976
95Non-small cell lung cancer_Homo sapiens_hsa052230.62850303
96Regulation of autophagy_Homo sapiens_hsa041400.61800370
97AMPK signaling pathway_Homo sapiens_hsa041520.61439187
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60822512
99Herpes simplex infection_Homo sapiens_hsa051680.60080113
100TNF signaling pathway_Homo sapiens_hsa046680.58236837
101PPAR signaling pathway_Homo sapiens_hsa033200.58165215
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57761478
103Thyroid hormone synthesis_Homo sapiens_hsa049180.57209888
104Fatty acid biosynthesis_Homo sapiens_hsa000610.56971481
105T cell receptor signaling pathway_Homo sapiens_hsa046600.56556109
106Phenylalanine metabolism_Homo sapiens_hsa003600.56535361
107Sulfur relay system_Homo sapiens_hsa041220.56355999
108HTLV-I infection_Homo sapiens_hsa051660.55470159
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55383285
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.54957733
111Folate biosynthesis_Homo sapiens_hsa007900.54639719
112Proteoglycans in cancer_Homo sapiens_hsa052050.54638195
113Galactose metabolism_Homo sapiens_hsa000520.54324351
114MAPK signaling pathway_Homo sapiens_hsa040100.53997941
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53110545
116Estrogen signaling pathway_Homo sapiens_hsa049150.52969786
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.52729107
118Hippo signaling pathway_Homo sapiens_hsa043900.52488217
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.50786594
120Serotonergic synapse_Homo sapiens_hsa047260.50699807
121Notch signaling pathway_Homo sapiens_hsa043300.49487363
122Insulin secretion_Homo sapiens_hsa049110.48558033
123Pyrimidine metabolism_Homo sapiens_hsa002400.48209211
124Small cell lung cancer_Homo sapiens_hsa052220.48172035
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48097645
126Histidine metabolism_Homo sapiens_hsa003400.47484421
127DNA replication_Homo sapiens_hsa030300.47411168
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.47187853
129Starch and sucrose metabolism_Homo sapiens_hsa005000.46192661
130Prostate cancer_Homo sapiens_hsa052150.45682527
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45434362
132Focal adhesion_Homo sapiens_hsa045100.45403401
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44419180
134Glioma_Homo sapiens_hsa052140.44250393
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.43045513
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42319091
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41889859
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41572557
139Cocaine addiction_Homo sapiens_hsa050300.40324385
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39489789
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38283594
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36355797
143Melanoma_Homo sapiens_hsa052180.32329314
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.31786310
145ErbB signaling pathway_Homo sapiens_hsa040120.27600936
146Glucagon signaling pathway_Homo sapiens_hsa049220.25373427
147Arginine and proline metabolism_Homo sapiens_hsa003300.25187699
148NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25178124
149Apoptosis_Homo sapiens_hsa042100.25133175
150Malaria_Homo sapiens_hsa051440.25103226
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.24590562
152cAMP signaling pathway_Homo sapiens_hsa040240.22350285
153Epstein-Barr virus infection_Homo sapiens_hsa051690.19423395
154HIF-1 signaling pathway_Homo sapiens_hsa040660.18906301
155Influenza A_Homo sapiens_hsa051640.18496548

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