ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.34586878
2	synaptic vesicle maturation (GO:0016188)	5.34233264
3	acrosome reaction (GO:0007340)	4.65553343
4	glutamate secretion (GO:0014047)	4.55758481
5	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.49763060
6	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	4.36188691
7	sperm motility (GO:0030317)	4.31041652
8	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.13505254
9	postsynaptic membrane organization (GO:0001941)	4.13229246
10	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.08821749
11	calcium ion-dependent exocytosis (GO:0017156)	3.90519050
12	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.81093089
13	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.75883455
14	synaptic vesicle exocytosis (GO:0016079)	3.74886977
15	cochlea development (GO:0090102)	3.69631325
16	cellular ketone body metabolic process (GO:0046950)	3.67012522
17	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.66636435
18	protein localization to synapse (GO:0035418)	3.57526805
19	regulation of synaptic vesicle exocytosis (GO:2000300)	3.57208218
20	protein polyglutamylation (GO:0018095)	3.53706697
21	primary amino compound metabolic process (GO:1901160)	3.53107498
22	gamma-aminobutyric acid transport (GO:0015812)	3.52212502
23	rRNA methylation (GO:0031167)	3.48669452
24	proline transport (GO:0015824)	3.48037599
25	adaptation of signaling pathway (GO:0023058)	3.46857088
26	ketone body metabolic process (GO:1902224)	3.46846277
27	positive regulation of membrane potential (GO:0045838)	3.44844355
28	microtubule nucleation (GO:0007020)	3.43231417
29	neuronal action potential propagation (GO:0019227)	3.41368154
30	multicellular organism reproduction (GO:0032504)	3.38172242
31	regulation of cilium movement (GO:0003352)	3.32444321
32	membrane depolarization during action potential (GO:0086010)	3.32092060
33	behavioral defense response (GO:0002209)	3.28295961
34	behavioral fear response (GO:0001662)	3.28295961
35	coenzyme catabolic process (GO:0009109)	3.27097777
36	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.26772539
37	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.26283125
38	neurotransmitter secretion (GO:0007269)	3.24434577
39	innervation (GO:0060384)	3.20612499
40	synaptic transmission, glutamatergic (GO:0035249)	3.19574392
41	glutamate receptor signaling pathway (GO:0007215)	3.17448721
42	single strand break repair (GO:0000012)	3.16432644
43	neuron cell-cell adhesion (GO:0007158)	3.14195018
44	neuromuscular synaptic transmission (GO:0007274)	3.12703840
45	regulation of synaptic vesicle transport (GO:1902803)	3.11767451
46	neuron-neuron synaptic transmission (GO:0007270)	3.11595364
47	regulation of excitatory postsynaptic membrane potential (GO:0060079)	3.10633070
48	behavioral response to nicotine (GO:0035095)	3.08846367
49	fusion of sperm to egg plasma membrane (GO:0007342)	3.07595034
50	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.07201001
51	sperm-egg recognition (GO:0035036)	3.06238246
52	vocalization behavior (GO:0071625)	3.02485965
53	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.99868144
54	presynaptic membrane assembly (GO:0097105)	2.98806641
55	cyclic nucleotide catabolic process (GO:0009214)	2.96057397
56	adult feeding behavior (GO:0008343)	2.95747741
57	cAMP catabolic process (GO:0006198)	2.95490914
58	fear response (GO:0042596)	2.95474030
59	regulation of neurotransmitter secretion (GO:0046928)	2.95163023
60	spermatid development (GO:0007286)	2.93336258
61	rRNA modification (GO:0000154)	2.91724325
62	locomotory exploration behavior (GO:0035641)	2.90551697
63	regulation of postsynaptic membrane potential (GO:0060078)	2.89829706
64	membrane depolarization (GO:0051899)	2.86668034
65	regulation of neurotransmitter transport (GO:0051588)	2.85884978
66	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.85460782
67	sperm capacitation (GO:0048240)	2.82053425
68	homocysteine metabolic process (GO:0050667)	2.80809969
69	inner ear receptor cell development (GO:0060119)	2.79336663
70	neurotransmitter transport (GO:0006836)	2.78571761
71	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.78194137
72	exploration behavior (GO:0035640)	2.77281665
73	regulation of glutamate receptor signaling pathway (GO:1900449)	2.77063889
74	detection of light stimulus involved in visual perception (GO:0050908)	2.76568222
75	detection of light stimulus involved in sensory perception (GO:0050962)	2.76568222
76	adenosine metabolic process (GO:0046085)	2.76117108
77	auditory behavior (GO:0031223)	2.76092743
78	protein localization to cilium (GO:0061512)	2.74582989
79	C4-dicarboxylate transport (GO:0015740)	2.72233091
80	regulation of transcription involved in cell fate commitment (GO:0060850)	2.70070513
81	neuronal action potential (GO:0019228)	2.68856662
82	regulation of neuronal synaptic plasticity (GO:0048168)	2.68497194
83	regulation of microtubule-based movement (GO:0060632)	2.68203288
84	positive regulation of catecholamine secretion (GO:0033605)	2.67308777
85	regulation of neurotransmitter uptake (GO:0051580)	2.67100693
86	microtubule polymerization or depolymerization (GO:0031109)	2.66403034
87	presynaptic membrane organization (GO:0097090)	2.66263520
88	spermatid nucleus differentiation (GO:0007289)	2.64978237
89	regulation of transmission of nerve impulse (GO:0051969)	2.63707657
90	transmission of nerve impulse (GO:0019226)	2.63642307
91	regulation of sarcomere organization (GO:0060297)	2.63164633
92	alanine transport (GO:0032328)	2.62584498
93	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.60959275
94	plasma membrane fusion (GO:0045026)	2.59843863
95	establishment of protein localization to Golgi (GO:0072600)	2.58192952
96	reproduction (GO:0000003)	2.57421757
97	cilium or flagellum-dependent cell motility (GO:0001539)	2.57300146
98	synaptic transmission (GO:0007268)	2.56967470
99	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.56473321
100	axonemal dynein complex assembly (GO:0070286)	2.55895409

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.74165533
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.73985831
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.43211764
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.85588513
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.66103464
6	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.48435912
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.42395778
8	REST_21632747_ChIP-Seq_MESCs_Mouse	2.39564186
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.36856621
10	VDR_22108803_ChIP-Seq_LS180_Human	2.22498119
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.20772211
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.16377886
13	P300_19829295_ChIP-Seq_ESCs_Human	2.08016485
14	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.07727413
15	DROSHA_22980978_ChIP-Seq_HELA_Human	2.02604931
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.01274897
17	FUS_26573619_Chip-Seq_HEK293_Human	1.98144087
18	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.89162749
19	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.86804231
20	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.79668656
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77710788
22	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.76816034
23	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.73383856
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.72977110
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72919493
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.72209145
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.71354425
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.69695711
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69695711
30	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.65959321
31	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.64310664
32	STAT3_23295773_ChIP-Seq_U87_Human	1.59007023
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58741779
34	AR_25329375_ChIP-Seq_VCAP_Human	1.54680069
35	IGF1R_20145208_ChIP-Seq_DFB_Human	1.54283356
36	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.49894296
37	RUNX2_22187159_ChIP-Seq_PCA_Human	1.49730241
38	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.48405857
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46848530
40	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.46720888
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.45985125
42	TCF4_23295773_ChIP-Seq_U87_Human	1.45012589
43	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.41165275
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.39428211
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.39338343
46	AR_21572438_ChIP-Seq_LNCaP_Human	1.38928636
47	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.38507183
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37230158
49	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36918730
50	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.36005731
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.35998986
52	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.34193884
53	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.34193884
54	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32633462
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32633462
56	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.31925617
57	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30888228
58	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.30326932
59	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.30127828
60	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29794408
61	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.27856797
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.26797500
63	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.26005126
64	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.25943606
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25162008
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24166230
67	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.23625159
68	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.22679539
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.22460645
70	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.21931099
71	EWS_26573619_Chip-Seq_HEK293_Human	1.20915361
72	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19362715
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18276643
74	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17993915
75	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.17339229
76	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13399553
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13225163
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13225163
79	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.12290168
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11903558
81	KDM2B_26808549_Chip-Seq_REH_Human	1.11745939
82	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.11554735
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11001320
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.10305131
85	TP53_22573176_ChIP-Seq_HFKS_Human	1.08444712
86	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.07973404
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07872527
88	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.07390152
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06919898
90	JUN_21703547_ChIP-Seq_K562_Human	1.06900052
91	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06880261
92	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06860638
93	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.04975924
94	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.03801672
95	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02829853
96	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02775849
97	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02770276
98	* NCOR_22424771_ChIP-Seq_293T_Human	0.99965711
99	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.99418756
100	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.98774598

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.00782509
2	MP0003880_abnormal_central_pattern	3.86100461
3	MP0001968_abnormal_touch/_nociception	3.16531101
4	MP0009046_muscle_twitch	3.05003176
5	MP0005410_abnormal_fertilization	2.97214225
6	MP0003635_abnormal_synaptic_transmissio	2.94119936
7	MP0004270_analgesia	2.91496816
8	MP0009745_abnormal_behavioral_response	2.88073751
9	MP0005423_abnormal_somatic_nervous	2.76148702
10	MP0001501_abnormal_sleep_pattern	2.71041469
11	MP0002736_abnormal_nociception_after	2.68428487
12	MP0001486_abnormal_startle_reflex	2.63158697
13	MP0002064_seizures	2.61168181
14	MP0002272_abnormal_nervous_system	2.60622081
15	MP0005646_abnormal_pituitary_gland	2.56790015
16	MP0002735_abnormal_chemical_nociception	2.39133106
17	MP0005670_abnormal_white_adipose	2.38980638
18	MP0002063_abnormal_learning/memory/cond	2.37247080
19	MP0002572_abnormal_emotion/affect_behav	2.33418624
20	MP0005551_abnormal_eye_electrophysiolog	2.31966133
21	MP0004885_abnormal_endolymph	2.25050343
22	MP0000569_abnormal_digit_pigmentation	2.08836601
23	MP0002734_abnormal_mechanical_nocicepti	2.01875361
24	MP0003787_abnormal_imprinting	1.97355070
25	MP0002733_abnormal_thermal_nociception	1.77410356
26	MP0001970_abnormal_pain_threshold	1.73426708
27	MP0008877_abnormal_DNA_methylation	1.71578921
28	MP0006276_abnormal_autonomic_nervous	1.69806078
29	MP0008872_abnormal_physiological_respon	1.64267893
30	MP0002067_abnormal_sensory_capabilities	1.62640810
31	MP0008569_lethality_at_weaning	1.56123731
32	MP0002557_abnormal_social/conspecific_i	1.55754465
33	MP0001984_abnormal_olfaction	1.54958507
34	MP0003698_abnormal_male_reproductive	1.52735023
35	MP0004147_increased_porphyrin_level	1.52304837
36	MP0002229_neurodegeneration	1.48850013
37	MP0005253_abnormal_eye_physiology	1.46825443
38	MP0010386_abnormal_urinary_bladder	1.40118296
39	MP0001348_abnormal_lacrimal_gland	1.38328078
40	MP0002184_abnormal_innervation	1.34200872
41	MP0000015_abnormal_ear_pigmentation	1.31674060
42	MP0001963_abnormal_hearing_physiology	1.31569871
43	MP0003011_delayed_dark_adaptation	1.29825474
44	MP0001905_abnormal_dopamine_level	1.28337165
45	MP0005645_abnormal_hypothalamus_physiol	1.28291653
46	MP0004742_abnormal_vestibular_system	1.26151301
47	MP0001440_abnormal_grooming_behavior	1.25537525
48	MP0001502_abnormal_circadian_rhythm	1.19064152
49	MP0003633_abnormal_nervous_system	1.17546722
50	MP0002234_abnormal_pharynx_morphology	1.17017813
51	MP0002837_dystrophic_cardiac_calcinosis	1.16903113
52	MP0003195_calcinosis	1.16777943
53	MP0000372_irregular_coat_pigmentation	1.14771398
54	MP0001485_abnormal_pinna_reflex	1.14673681
55	MP0002882_abnormal_neuron_morphology	1.13983750
56	MP0008995_early_reproductive_senescence	1.13054430
57	MP0002066_abnormal_motor_capabilities/c	1.10801977
58	MP0000955_abnormal_spinal_cord	1.09551271
59	MP0002938_white_spotting	1.08639863
60	MP0002909_abnormal_adrenal_gland	1.08376909
61	MP0001929_abnormal_gametogenesis	1.04333017
62	MP0005386_behavior/neurological_phenoty	1.03619270
63	MP0004924_abnormal_behavior	1.03619270
64	MP0000778_abnormal_nervous_system	1.03578223
65	MP0004043_abnormal_pH_regulation	1.02734519
66	MP0002102_abnormal_ear_morphology	1.02328667
67	MP0005174_abnormal_tail_pigmentation	1.00631487
68	MP0000631_abnormal_neuroendocrine_gland	1.00491232
69	MP0004811_abnormal_neuron_physiology	0.99670131
70	MP0000013_abnormal_adipose_tissue	0.98119183
71	MP0003879_abnormal_hair_cell	0.96116939
72	MP0000026_abnormal_inner_ear	0.95282040
73	MP0002095_abnormal_skin_pigmentation	0.94965289
74	MP0002752_abnormal_somatic_nervous	0.93768211
75	MP0003631_nervous_system_phenotype	0.91649097
76	MP0002069_abnormal_eating/drinking_beha	0.89946471
77	MP0006072_abnormal_retinal_apoptosis	0.86678239
78	MP0002638_abnormal_pupillary_reflex	0.85936726
79	MP0005171_absent_coat_pigmentation	0.85007823
80	MP0009780_abnormal_chondrocyte_physiolo	0.83348969
81	MP0005332_abnormal_amino_acid	0.81740221
82	MP0002161_abnormal_fertility/fecundity	0.81212040
83	MP0004133_heterotaxia	0.79444180
84	MP0001764_abnormal_homeostasis	0.77490018
85	MP0004142_abnormal_muscle_tone	0.76584850
86	MP0001188_hyperpigmentation	0.74988933
87	MP0000639_abnormal_adrenal_gland	0.73884124
88	MP0009697_abnormal_copulation	0.71100122
89	MP0002876_abnormal_thyroid_physiology	0.71002654
90	MP0003646_muscle_fatigue	0.68575927
91	MP0005535_abnormal_body_temperature	0.67231009
92	MP0002152_abnormal_brain_morphology	0.65527195
93	MP0000920_abnormal_myelination	0.65250881
94	MP0002822_catalepsy	0.64588532
95	MP0004085_abnormal_heartbeat	0.63218285
96	MP0003121_genomic_imprinting	0.63130205
97	MP0005377_hearing/vestibular/ear_phenot	0.62822429
98	MP0003878_abnormal_ear_physiology	0.62822429
99	MP0001529_abnormal_vocalization	0.62504951
100	MP0002210_abnormal_sex_determination	0.62387123

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Action tremor (HP:0002345)	4.73533860
2	Febrile seizures (HP:0002373)	4.50205027
3	Focal motor seizures (HP:0011153)	4.36381904
4	Atonic seizures (HP:0010819)	4.33358895
5	Abnormality of alanine metabolism (HP:0010916)	4.15662700
6	Hyperalaninemia (HP:0003348)	4.15662700
7	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.15662700
8	Myokymia (HP:0002411)	4.10633702
9	Progressive cerebellar ataxia (HP:0002073)	4.08398606
10	Attenuation of retinal blood vessels (HP:0007843)	3.90516877
11	Congenital sensorineural hearing impairment (HP:0008527)	3.88520525
12	Focal seizures (HP:0007359)	3.72958769
13	Epileptic encephalopathy (HP:0200134)	3.55247739
14	Hyperventilation (HP:0002883)	3.29638423
15	Severe visual impairment (HP:0001141)	3.24249820
16	Gaze-evoked nystagmus (HP:0000640)	3.20551223
17	Constricted visual fields (HP:0001133)	3.14600508
18	Abnormality of macular pigmentation (HP:0008002)	3.03857214
19	Pancreatic fibrosis (HP:0100732)	3.00238492
20	Limb dystonia (HP:0002451)	2.96968776
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.86588648
22	Decreased central vision (HP:0007663)	2.83586725
23	Pancreatic cysts (HP:0001737)	2.80226867
24	Congenital stationary night blindness (HP:0007642)	2.80049932
25	Absent/shortened dynein arms (HP:0200106)	2.77750571
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.77750571
27	True hermaphroditism (HP:0010459)	2.77011262
28	Cerebral hypomyelination (HP:0006808)	2.75216453
29	Abnormality of midbrain morphology (HP:0002418)	2.73968634
30	Molar tooth sign on MRI (HP:0002419)	2.73968634
31	Nephronophthisis (HP:0000090)	2.70763361
32	Dialeptic seizures (HP:0011146)	2.65397687
33	Absence seizures (HP:0002121)	2.63766183
34	Abnormal respiratory motile cilium morphology (HP:0005938)	2.62719230
35	Abnormal respiratory epithelium morphology (HP:0012253)	2.62719230
36	Inability to walk (HP:0002540)	2.61201728
37	Absent speech (HP:0001344)	2.49990360
38	Chronic hepatic failure (HP:0100626)	2.48859405
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.48516397
40	Amblyopia (HP:0000646)	2.47870620
41	White forelock (HP:0002211)	2.45126826
42	Progressive inability to walk (HP:0002505)	2.44177189
43	Bony spicule pigmentary retinopathy (HP:0007737)	2.43616788
44	Delusions (HP:0000746)	2.40130321
45	Broad-based gait (HP:0002136)	2.39828148
46	Gait imbalance (HP:0002141)	2.36947349
47	Hemiparesis (HP:0001269)	2.28007020
48	Patchy hypopigmentation of hair (HP:0011365)	2.20945847
49	Intention tremor (HP:0002080)	2.20904019
50	Abnormality of the renal medulla (HP:0100957)	2.15657500
51	Medial flaring of the eyebrow (HP:0010747)	2.13186484
52	Cystic liver disease (HP:0006706)	2.11830677
53	Generalized tonic-clonic seizures (HP:0002069)	2.09239667
54	Impaired vibration sensation in the lower limbs (HP:0002166)	2.08663783
55	Keratoconus (HP:0000563)	2.06430830
56	Increased corneal curvature (HP:0100692)	2.06430830
57	Poor eye contact (HP:0000817)	2.06127062
58	Abnormal ciliary motility (HP:0012262)	2.06080827
59	Pendular nystagmus (HP:0012043)	2.02913747
60	Nephrogenic diabetes insipidus (HP:0009806)	2.02476104
61	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.00819315
62	Hypoplasia of the fovea (HP:0007750)	2.00819315
63	Abnormality of the labia minora (HP:0012880)	1.98927385
64	Chorioretinal atrophy (HP:0000533)	1.98534061
65	Epileptiform EEG discharges (HP:0011182)	1.98416052
66	Tubulointerstitial nephritis (HP:0001970)	1.98160245
67	Heterochromia iridis (HP:0001100)	1.95896130
68	Congenital primary aphakia (HP:0007707)	1.95763429
69	CNS hypomyelination (HP:0003429)	1.90203161
70	Ankle clonus (HP:0011448)	1.88014857
71	EEG with generalized epileptiform discharges (HP:0011198)	1.85889435
72	Clonus (HP:0002169)	1.84394786
73	Papilledema (HP:0001085)	1.84224853
74	Dysdiadochokinesis (HP:0002075)	1.81568315
75	Abolished electroretinogram (ERG) (HP:0000550)	1.80710313
76	Intestinal atresia (HP:0011100)	1.80072232
77	Abnormality of the renal cortex (HP:0011035)	1.80011822
78	Hypsarrhythmia (HP:0002521)	1.79598641
79	Poor speech (HP:0002465)	1.79522059
80	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78939184
81	Diplopia (HP:0000651)	1.78611730
82	Abnormality of binocular vision (HP:0011514)	1.78611730
83	Astigmatism (HP:0000483)	1.77241459
84	Genital tract atresia (HP:0001827)	1.75268895
85	Postural instability (HP:0002172)	1.74380142
86	Insulin-resistant diabetes mellitus (HP:0000831)	1.73393921
87	Status epilepticus (HP:0002133)	1.72066517
88	Abnormality of the fovea (HP:0000493)	1.70547495
89	Photophobia (HP:0000613)	1.69423928
90	Dysmetria (HP:0001310)	1.69071448
91	Spastic gait (HP:0002064)	1.68852802
92	Anencephaly (HP:0002323)	1.68842475
93	Abnormal eating behavior (HP:0100738)	1.68531143
94	Anxiety (HP:0000739)	1.67872052
95	Polyphagia (HP:0002591)	1.66678244
96	Drooling (HP:0002307)	1.66329600
97	Truncal ataxia (HP:0002078)	1.64975318
98	Polydipsia (HP:0001959)	1.64958269
99	Abnormal drinking behavior (HP:0030082)	1.64958269
100	Generalized aminoaciduria (HP:0002909)	1.63576242

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.42906580
2	MARK1	3.19224882
3	MAP4K2	3.11820015
4	EPHA4	3.09191887
5	CASK	2.99386792
6	NTRK3	2.97105849
7	PLK2	2.33634007
8	NTRK2	2.21156521
9	PLK4	2.05931539
10	PINK1	2.05207540
11	MAP3K4	1.98550706
12	NEK1	1.94372389
13	DAPK2	1.93872435
14	INSRR	1.83993865
15	MAPK13	1.82619254
16	MINK1	1.71554655
17	UHMK1	1.68061088
18	PAK6	1.55354889
19	STK38	1.49815893
20	ADRBK2	1.48330818
21	TRIM28	1.44024572
22	PRKCG	1.43724724
23	OXSR1	1.36258636
24	MAP2K7	1.36050999
25	GRK1	1.35109649
26	ACVR1B	1.31010352
27	CAMK1	1.28672176
28	SGK223	1.23461959
29	SGK494	1.23461959
30	TESK1	1.22180721
31	PHKG1	1.21193364
32	PHKG2	1.21193364
33	CAMKK2	1.17840075
34	WNK3	1.16706036
35	GRK5	1.16218709
36	PRKD3	1.16051901
37	PAK3	1.15184999
38	PRKCE	1.14170298
39	NEK6	1.12315854
40	BCKDK	1.10109067
41	CSNK1G2	1.07956578
42	CCNB1	1.07704908
43	DYRK2	1.06831171
44	CDK5	1.03197534
45	BMPR1B	1.00201035
46	CAMK2A	1.00170555
47	TAOK3	0.99019058
48	AKT3	0.96312883
49	NUAK1	0.93482799
50	STK38L	0.92722017
51	ZAK	0.92699265
52	BRD4	0.91166133
53	STK39	0.85362699
54	PDK2	0.85230659
55	SGK2	0.83408068
56	TNK2	0.81663039
57	CSNK1A1L	0.80145691
58	CSNK1G3	0.80136513
59	PKN1	0.77383807
60	DAPK1	0.77135841
61	ADRBK1	0.75879753
62	CSNK1G1	0.74839374
63	CAMK1G	0.74715322
64	CSNK1A1	0.74082404
65	CAMK2B	0.73834678
66	PTK2B	0.68898810
67	CAMKK1	0.68614872
68	MAP2K6	0.68603504
69	WNK4	0.67524294
70	CAMK1D	0.66721954
71	PRKCH	0.66187827
72	TNIK	0.65527112
73	PNCK	0.61602075
74	DDR2	0.61462722
75	MAP3K12	0.59951707
76	MAP3K9	0.58184005
77	PBK	0.57002901
78	MAPKAPK5	0.56203319
79	CAMK4	0.55392304
80	DYRK1A	0.53964612
81	CDK3	0.53955398
82	NTRK1	0.50186112
83	STK11	0.49652977
84	PRKG1	0.49270767
85	CDK19	0.49087510
86	PRKCA	0.48619762
87	LMTK2	0.47437197
88	VRK1	0.46746245
89	CAMK2D	0.46102471
90	PRKACA	0.44020526
91	FER	0.42578722
92	SGK1	0.41826134
93	PDK1	0.40320132
94	LIMK1	0.40152503
95	SIK2	0.39163904
96	WNK1	0.39033906
97	SGK3	0.37981626
98	MAP2K1	0.37711053
99	CDK9	0.37446544
100	BCR	0.35616101

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.38310055
2	Morphine addiction_Homo sapiens_hsa05032	2.94577453
3	GABAergic synapse_Homo sapiens_hsa04727	2.93202914
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.84460289
5	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.79097094
6	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.57006027
7	Circadian entrainment_Homo sapiens_hsa04713	2.37797490
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.33191959
9	Taste transduction_Homo sapiens_hsa04742	2.31725613
10	Glutamatergic synapse_Homo sapiens_hsa04724	2.31370072
11	Olfactory transduction_Homo sapiens_hsa04740	2.11644813
12	Phototransduction_Homo sapiens_hsa04744	1.99402275
13	Insulin secretion_Homo sapiens_hsa04911	1.85516561
14	Dopaminergic synapse_Homo sapiens_hsa04728	1.83431274
15	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.82643880
16	Butanoate metabolism_Homo sapiens_hsa00650	1.82299199
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.82005376
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.80557140
19	Amphetamine addiction_Homo sapiens_hsa05031	1.72160590
20	Salivary secretion_Homo sapiens_hsa04970	1.63892635
21	Serotonergic synapse_Homo sapiens_hsa04726	1.61354698
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.41605937
23	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.37513283
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.32818043
25	Arginine biosynthesis_Homo sapiens_hsa00220	1.29236606
26	Cholinergic synapse_Homo sapiens_hsa04725	1.28711471
27	Calcium signaling pathway_Homo sapiens_hsa04020	1.27858028
28	Cocaine addiction_Homo sapiens_hsa05030	1.26510836
29	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.24356063
30	One carbon pool by folate_Homo sapiens_hsa00670	1.23683507
31	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.23360897
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22915172
33	Gastric acid secretion_Homo sapiens_hsa04971	1.19974729
34	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.18878508
35	Regulation of autophagy_Homo sapiens_hsa04140	1.16664893
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.16355198
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.14465276
38	Renin secretion_Homo sapiens_hsa04924	1.14465205
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.09695220
40	Long-term potentiation_Homo sapiens_hsa04720	1.09234631
41	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.06511688
42	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.01688575
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.00080668
44	cAMP signaling pathway_Homo sapiens_hsa04024	0.99986896
45	Propanoate metabolism_Homo sapiens_hsa00640	0.97580751
46	Arginine and proline metabolism_Homo sapiens_hsa00330	0.95853101
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.95622199
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93936240
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.90399317
50	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.84994275
51	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.83054508
52	Circadian rhythm_Homo sapiens_hsa04710	0.81666417
53	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.81053646
54	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.80664738
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79183877
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.77214882
57	Basal transcription factors_Homo sapiens_hsa03022	0.76006050
58	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.75797620
59	Peroxisome_Homo sapiens_hsa04146	0.75461659
60	Long-term depression_Homo sapiens_hsa04730	0.75417136
61	ABC transporters_Homo sapiens_hsa02010	0.74486035
62	Mineral absorption_Homo sapiens_hsa04978	0.73944344
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.72931332
64	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.72308556
65	Oocyte meiosis_Homo sapiens_hsa04114	0.71593559
66	Cardiac muscle contraction_Homo sapiens_hsa04260	0.70063135
67	Retinol metabolism_Homo sapiens_hsa00830	0.66839021
68	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.63232833
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.60560856
70	Oxidative phosphorylation_Homo sapiens_hsa00190	0.59437647
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58646424
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57883233
73	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.57337958
74	Phenylalanine metabolism_Homo sapiens_hsa00360	0.54791149
75	Fanconi anemia pathway_Homo sapiens_hsa03460	0.53611501
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.53200685
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52828178
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50047130
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.49467594
80	Sulfur relay system_Homo sapiens_hsa04122	0.49106058
81	Purine metabolism_Homo sapiens_hsa00230	0.48974579
82	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.45456809
83	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.45092411
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.42623670
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42053350
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41969908
87	Vibrio cholerae infection_Homo sapiens_hsa05110	0.41863436
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41562028
89	Pancreatic secretion_Homo sapiens_hsa04972	0.41453057
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41086818
91	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.37766235
92	Metabolic pathways_Homo sapiens_hsa01100	0.37506206
93	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.37471225
94	Histidine metabolism_Homo sapiens_hsa00340	0.34286997
95	Fatty acid degradation_Homo sapiens_hsa00071	0.33348512
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33066886
97	Bile secretion_Homo sapiens_hsa04976	0.31705481
98	Alzheimers disease_Homo sapiens_hsa05010	0.31698016
99	Alcoholism_Homo sapiens_hsa05034	0.31288238
100	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.30887475

PABPC1L2A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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